Class / Patent application number | Description | Number of patent applications / Date published |
435400510 | Involving a monolayer, smear or suspension of microorganisms or cells | 22 |
20090047704 | Combination of a Histological or Cytological Fixing Agent and One or More Photoactivatable Compounds of the Quinone Family, In Particular Hypericin, Hypocrellin A and Hypocrellin B - The invention relates to the combination, in solution or in a kit, of a histological or cytological fixing solution and of one or more photoactivatable compounds of the family of quinones, in particular, hypericin, hypocrellin A and/or hypocrellin B. The invention also relates to a method for labeling cells or tissues by one or more photoactivatable compounds of the family of quinones, in which the cells or tissues in contact with a histological or cytological fixing solution are labeled, simultaneously or subsequently, by the photoactivatable compound(s) of the family of quinones. | 02-19-2009 |
20090155841 | SMEAR SLIDE PREPARING APPARATUS AND SMEAR SLIDE PREPARING METHOD - The present invention is to present a smear slide preparing apparatus capable of properly providing sample-related information on a predetermined area of a slide glass even when glass shards and dust and the like are attached to the predetermined area. A smear slide preparing apparatus comprises: a smear section for smearing a sample on a slide glass; an attached matter removing section for removing attached matter which is attached to a sample-related information area of the slide glass; and a sample-related information providing section for providing sample-related information which is related to the sample on the sample-related information area of the slide glass, the attached matter having been removed from the sample-related information area. | 06-18-2009 |
20090233331 | METHOD AND APPARATUS FOR PREPARING CYTOLOGICAL SPECIMENS - An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto. | 09-17-2009 |
20090263857 | METHOD FOR ANTIGEN RETRIEVAL AND SUBMERSION FLUID COMPOSITIONS FOR USE THEREIN - The present invention relates to a method for retrieving the antigenicity of a formaldehyde-fixed sample for immunological staining and to compositions used in such a method. A method of the invention comprises submerging a sample in a submersion fluid composition comprising an osmotically active compound and heating the said submerged sample under pressure. The present invention also discloses advantageous submersion fluid compositions for retrieving the antigenicity of a formaldehyde-fixed samples and their use. | 10-22-2009 |
20090275076 | CELL SAMPLE PREPARATION METHOD AND APPARATUS - An apparatus and method for automatic thin-layer cell sample slide preparation without requiring human intervention are disclosed. According to one embodiment, a cell sample is measured to derive a cell sample measurement. An estimation of total cellularity of the cell sample is determined based upon the cell sample measurement. A differential volume of diluent is dispensed to the cell sample based upon the estimation of total cellularity of the cell sample to form a cell suspension. In one embodiment, a differential volume of the cell suspension and a differential volume of cell adherent may be combined based upon the estimation of total cellularity of the cell sample to form a cell mixture. A differential volume of the cell suspension or cell mixture (if an adherent is mixed with the cell suspension) is dispensed onto a surface of a sample slide. | 11-05-2009 |
20110151505 | Substance for Specimen Preparations and Related Methods - Disclosed are substances and methods for preparing cytological specimens. | 06-23-2011 |
20110223632 | SMEAR STAINING APPARATUS, SMEAR PREPARING APPARATUS, SMEAR PROCESSING SYSTEM, AND METHOD FOR DETERMINING STAINING CONDITION - A smear staining apparatus comprising: a staining section which stains a smear sample with a quantity of stain fluid; and a controller, wherein the controller: receives information regarding a stain state on a smear sample which is stained according to a first staining condition by the staining section; and determines a second staining condition on the basis of the information and a target value which defines a targeted stain state, is disclosed. A smear preparing apparatus, a smear processing system and method for determining staining condition are also disclosed. | 09-15-2011 |
20130137137 | AUTOMATED SYSTEM TO CREATE A CELL SMEAR - A method of creating a layer of cells on a surface. In some embodiments, the method includes the steps of engaging a smear tool against the surface with an engagement force; flexing a portion of the smear tool to change an orientation of the smear tool with respect to the surface; moving the smear tool along the surface through a sample comprising cells suspended in a liquid; and adhering the sample to the surface to thereby create a layer of cells. Another method according to the invention creates a layer of cells on a surface by mixing the sample prior to and/or during the smear. The invention also includes systems for implementing the methods. | 05-30-2013 |
20130302852 | Hematoxylin Staining Method - The present invention relates to processes for staining biological samples, and in particular to automated processes for staining biological sample with hematoxylin stains. In the processes and systems of the invention, separate hematein and mordant solutions are provided which may be premixed prior to application to a biological sample. This method prevents precipitation common in hematein staining solutions and which fouls automated slide/sample processing equipment. | 11-14-2013 |
20130309716 | Methods For Inactiviation And/or Extraction of A Fungus Test Sample For Characterization And/or Identification Using Mass Spectrometry - The present invention is directed to a method for inactivation and/or extraction of fungus samples (e.g., mold or yeast samples), the method comprising the following sequential steps: (a) acquiring a test sample known to contain or that may contain fungus and suspending the test sample in a container containing water and/or suspension medium; (b) adding ethanol to the suspension; (c) centrifuging the container to pellet the fungus and removing and discarding the supernatant; (d) resuspending the fungus in formic acid; (e) adding acetonitrile to the sample; (f) centrifuging the sample; and (g) recovering the supernatant. In accordance with the present invention, the recovered supernatant can be subjected to mass spectrometry analysis for characterization and/or identification of the unknown fungus. | 11-21-2013 |
20140127745 | METHOD, COMPOSITIONS AND DEVICE FOR PREPARING CYTOLOGICAL SPECIMENS - The invention relates to a method for preparing specimens from tissue samples for cytology microscopic examination, and includes inventive compositions and a device used in said method. The invention also includes a diagnostic kit comprising the inventive compositions and device. | 05-08-2014 |
20140178928 | METHOD AND APPARATUS FOR AUTOMATED STAINING OF BIOLOGICAL MATERIALS - Various embodiments of the present invention provide methods and systems for optimally staining biological samples for analysis. In one embodiment, images of a sample are recorded before and after the application of a staining reagent and a decolorization reagent. A difference image is then generated based at least in part on a comparison of the images of the sample recorded before and after the application of the staining and decolorization reagents. Application parameters of the staining and decolorization reagents are then corrected based at least in part on the difference image such that the reagents may be optimally reapplied to generate a final image of the sample that may enable a user to better differentiate at least one target of interest in the sample. In one example, embodiments of the present invention allow for the generation of images that show only Gram-positive bacteria or only Gram-negative bacteria. | 06-26-2014 |
20140255985 | TWO-PHOTON ENDOSCOPIC SCANNING ASSEMBLY FOR INFLAMMATORY DISEASE DETECTION - An endscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue. | 09-11-2014 |
20140335560 | Automated Microdissection Instrument - Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide. | 11-13-2014 |
20150010942 | FIXATIVE COMPOSITION FOR CYTOLOGY, CELL FIXATION METHOD AND ITS APPLICATIONS - The present invention refers to a fixative composition for cytology, comprised by an alcoholic base and toluidine blue, preferably mucous cells, like cells from the oral cavity and cells from exo and endocervix. | 01-08-2015 |
20150024429 | METHOD AND DEVICE FOR THE HOMOGENEOUS DISTRIBUTION OF SUSPENDED CELL COMPONENTS - A method for the homogeneous distribution of cell components suspended in a liquid on a surface and a device for the implementation thereof. | 01-22-2015 |
20150037837 | Cytological Method Using the Auto Fluorescence of White Corpuscles for the Early Diagnosis and the Monitoring of Infections - The present invention relates to an in vitro method for diagnosing the infectious state of an individual on the basis of a sample of white corpuscles arising from a biological specimen taken from an organ potentially infected by a pathogenic micro-organism of said individual, comprising at least the following two steps: i) measuring the mean cellular intensity of the autofluorescence of said sample, and ii) comparing the intensity measured in step i) with a control value, so as to determine the infectious state of said individual. The diagnostic method of the invention uses a routine optical material making it possible to work in wavelength regions which are compatible with the cellular autofluorescence, and thus constitutes a rapid, reliable and inexpensive aid for the diagnosis or monitoring of an infection in an individual. | 02-05-2015 |
20150044717 | DEVICES AND METHODS FOR OBSERVING EUKARYOTIC CELLS WITHOUT CELL WALL - The present invention relates to methods and devices for observing eukaryotic cells devoid of cell wall, in particular for observing the cytokinetic ring, the device comprising a plurality of wells suitable for containing only one single eukaryotic cell and characterized in that the dimensions of the wells constrain the cells into an oblong shape with a long axis parallel to the depth of the wells. | 02-12-2015 |
20150316453 | METHOD FOR FORMING A LIQUID FILM ON A SUBSTRATE - This method for forming a liquid film on a substrate comprises the steps of placing the substrate in a chamber, and depositing a composition on the substrate, the composition including water, introducing a volatile liquid into the chamber, and closing the chamber for a predetermined period, the volatile liquid evaporating in the chamber during this closing step. The method further comprises at least partial extraction, out of the chamber, vapor formed by the evaporation of the volatile liquid, this extraction producing spreading out of the composition on the substrate, said spread composition then forming the liquid film on the substrate. | 11-05-2015 |
20150316477 | METHOD, KIT AND SYSTEM FOR IMAGING A BLOOD SAMPLE - Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface. | 11-05-2015 |
20160169923 | SYSTEMS AND METHODS FOR MULTI-ANALYSIS | 06-16-2016 |
20160187235 | SAMPLE PROCESSING IMPROVEMENTS FOR QUANTITATIVE MICROSCOPY - Among other things, a diluted sample is generated based on mixing a small sample of blood with a one or more diluents. A thin film of the diluted sample is formed on the surface of a contact optical microscopy sensor. Red blood cells within a portion of the thin film of the diluted sample are illuminated using light of a predetermined wavelength. One or more images of the diluted sample are acquired based on illuminating the red blood cells within the portion of the thin film of the diluted sample. The acquired one or more images of the diluted sample are then processed. The mean corpuscular hemoglobin in the red blood cells within the portion of the thin film of the diluted sample is determined based on processing the acquired images of the diluted sample. | 06-30-2016 |