Entries |
Document | Title | Date |
20080213819 | Device for Preparing a Body Fluid for a Bacteriological Analysis - The invention concerns a device for preparing a body fluid for a bacteriological analysis thereof comprising a container provided with a chamber ( | 09-04-2008 |
20080248517 | Diagnostic Device - Diagnostic devices for detecting the presence of an analyte in a sample are provided. Devices of the present invention comprise a means for inducing a pressure differential on a sample to direct the sample to a test surface. In one embodiment, the means for inducing a pressure differential on a sample to direct the sample to a test surface comprises a syringe that can be used to draw a sample from an opening to a test surface. In other embodiments, the device also provides means for diluting a sample. In yet other embodiments, the device also provides a means | 10-09-2008 |
20080254500 | Microorganism-collecting chip, microorganism-collecting kit, method of quantifying microorganisms, specimen for confirming normal state of microorganism-quantifying apparatus and microorganism-quantifying apparatus - The invention aims to efficiently collect microorganisms from a test sample and accurately detect and quantify the collected microorganisms. | 10-16-2008 |
20080261262 | Lysis/Resealing Process and Device for Incorporating an Active Ingredient, in Particular Asparaginase or Inositol Hexaphosphate, in Erythrocytes - Lysis/resealing process for preparing erythrocytes which contain an active ingredient (e.g. aspariginase or inositol hexaphosphate), the process comprising the following steps: (1) placing a globular concentrate in suspension in an isotonic solution having a haematocrit level which is equal to or greater than 65%, with refrigeration at from +1 to +8° C., (2) measuring the osmotic fragility based on a sample of erythrocytes from that same globular concentrate, preferably on a sample of the suspension obtained in step (1), (3) lysis and internalisation procedure of the active ingredient, inside the same chamber, at a temperature which is constantly maintained at from +1 to +8° C., comprising allowing the erythrocyte suspension having a haematocrit level which is equal to or greater than 65% and a hypotonic lysis solution which is refrigerated at from +1 to +8° C. to circulate in a dialysis cartridge; the lysis parameters being adjusted in accordance with the osmotic fragility previously measured; and (4) resealing procedure carried out in a second chamber at a temperature of from +30 to +40° C. by means of a hypertonic solution. | 10-23-2008 |
20080274495 | Diagnostic Method for Testing Hydration and Other Conditions - Methods for the non-invasive collection of a liquid sample in small quantities, such as urine for testing hydration in infants and incontinent adults, directly at the source of that sample, isolation of the collected sample from a testing site, the transportation of that sample to a site for testing contained within the device itself, and the selective application of some or all of the specimen to a testing apparatus contained within the device itself, with a minimum of specimen handling required. Other aspects include a method and device for facilitating the reading of the result of the specimen test by a skilled or unskilled user, including means for determining that no adequate sample has been delivered to the testing site. | 11-06-2008 |
20090004688 | Sampling System and Method - A sampling system and method may use a kit that has a package enclosing a swab and a receptacle. The swab may have a shaft and a tip. The tip may be substantially made of calcium alginate. The receptacle may contain a diluent, such as sodium citrate, and glass beads. The swab may be used in an environment to sample microorganisms present on surfaces or in equipment. The kit may be used in a method of sampling and the resulting sample may be used in a method of quantitative testing. | 01-01-2009 |
20090029407 | Systems And Methods For Analyzing And Manipulating Biological Samples - A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell. | 01-29-2009 |
20090111141 | Method and Device for Studying Floating, Living Cells - Disclosed is a method of studying floating living cell by confining the cells floating in an aqueous medium in picowells located on a bottom surface of a top wall of a chamber. Disclosed is also a picowell-bearing device for the study of cells comprising a chamber having at least one picowell on a bottom surface of the chamber. Also disclosed is a picowell-bearing device for the study of cells comprising a chamber having at least one picowell on an internal surface and at least one moveable wall, a force applicator configured to removeably apply a substantially uniformly distributed force around the periphery of the moveable wall in a direction to retain the moveable wall secured to the chamber. | 04-30-2009 |
20090280523 | Method for determining the molecular composition of a target tissue or another body structure, and its diagnostic applications - The present invention relates to a sampling instrument adapted for taking a sample in situ and in vivo or taking a sample ex vivo of a target tissue or body structure, in a maximum quantity of less than 10 | 11-12-2009 |
20090305335 | Method for analysing a sample - This invention relates a method for analysing a biological sample by imaging, wherein sample processing and detection and optionally pre-treatment is performed in a single container. The invention further relates to a kit for use in said method. | 12-10-2009 |
20090325218 | Determination of lipid, hydrocarbon or biopolymer content in microorganisms - A method for determining the content of a bioproduct in a cell culture comprises
| 12-31-2009 |
20090325219 | DEVICE, SYSTEM AND ASSAY FOR MEASURING CELL MOTILITY - The present application relates to a device and system for measuring cell motility comprising a supporting substrate which includes at least one cell receiving zone and an agent receiving matrix provided on a matrix receiving zone, wherein interposed between the cell receiving zone and the agent receiving matrix is a bridging portion. In addition, methods of using said device and system and a kit relating to the device is provided. | 12-31-2009 |
20100047850 | METHOD AND DEVICE FOR RAPID DETECTION OF MICROORGANISMS BY CHANGING THE SHAPE OF MICRO-COLONIES IN MICRO-CHANNELS - This invention describes a method of rapid detection of micro-colonies of microorganisms by changing their shape from a regular semi-sphere to a long and thin cylinder. Cells are trapped by filtration in long (diameter/length=1/10-1/100), cylindrical, parallel, micro-channels that are open from both sides, and attached to a filter from one side. A micro-channel plate houses a multiplicity of micro-channels (diameter of each channel=1-20 μm, and length 100-1000 μm). The micro-channel plate with cells trapped on the surface of the filter is attached to a nutrient media agar block. Cells produce micro-colonies of a long and thin shape according the shape of the micro-channel. The growth of microorganisms in the micro-channels permits a change in the number of cells to accomplish light absorbance. Fewer cells need a shorter time to reproduce. Thus detection and counting of cells can be accomplished in a rapid fashion. The light absorbance can be enhanced by additional coloration of micro-colonies by cell dyes or artificial chromogenic or fluorogenic substrates. | 02-25-2010 |
20100086963 | AUTOMATED SEED SAMPLER AND METHODS OF SAMPLING, TESTING AND BULKING SEEDS - An automated system for sampling seeds generally includes an automated sampler operable to remove a tissue sample from a seed, a seed tray configured to receive from the automated sampler the seed from which the tissue sample is removed, and a sample tray configured to receive the tissue sample removed from the seed. A table supports the seed tray and the sample tray, and an index mechanism is operable to move the table to bring the seed tray into position for receiving from the automated sampler the seed from which the tissue sample is removed, and to bring the sample tray into position for receiving the tissue sample removed from the seed. | 04-08-2010 |
20100120083 | DISPOSABLE CASSETTE AND METHOD OF USE FOR BLOOD ANALYSIS ON BLOOD ANALYZER - A disposable cassette for blood analysis includes a housing having an upper panel and a sampling section having a filling inlet; at least one pair of chambers in a form of depression of the upper panel of the housing and sealed by a diaphragm; portions of the diaphragm over the chambers being flexible; and one or more channels adapted to interconnect the pair of chambers; one of the chambers containing a predetermined amount of a reagent for blood analysis; and a sample outlet disposed next to and connected to the chamber containing the reagent, the sample outlet including an outlet cavity recessed from the upper panel, a divider disposed therein, and a cover covering the outlet cavity; the sample outlet sealing the reagent to the chamber containing the reagent. Further disclosed is the method of using the disposable cassette for measurements of hematology parameters on a blood analyzer. | 05-13-2010 |
20100248294 | ANALYTIC SUBSTRATE COATING METHOD - An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production. | 09-30-2010 |
20100248295 | ANALYTIC SUBSTRATE COATING METHOD - An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production. | 09-30-2010 |
20100285520 | SAMPLE PREPARATION FOR ENVIRONMENTAL SAMPLING - A system and method for preparing samples to test an environmental surface for an analyte of interest. The system can include a deformable self-supporting receptacle comprising a reservoir, and a loaded substrate positioned in the reservoir of the deformable self-supporting receptacle. The loaded substrate can include a substrate and a source collected from the surface. The method can include combining the loaded substrate and a diluent in the reservoir, and agitating the loaded substrate and the diluent to form a liquid composition comprising the source and the diluent. | 11-11-2010 |
20100317051 | DEVICE FOR COLLECTING AND TRIGGERED RELEASE OF A BIOLOGICAL SAMPLE - The invention relates to a system for collecting a biological sample comprising a container having at least one open end, a closure fitting on or in said at least one open end, a holding element connected to said closure and a solid matrix on which said biological sample is deposited, and optionally at least one processing agent, wherein said solid matrix is at least partially transferable into a liquid or dissolved state by changing at least one physico-chemical property of the environment of said matrix without disintegration of the biomolecules comprised in said biological sample deposited on said matrix. | 12-16-2010 |
20110053210 | BLOOD ANALYZER, BLOOD ANALYSIS METHOD AND HEMOLYTIC AGENT - This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information. | 03-03-2011 |
20110076713 | Process of characterization of hepatocytes from goat - A process for characterization of hepatocytes cells in goat comprising isolating goat hepatocytes and characterizing the isolated hepatocytes by biochemical and molecular techniques to demonstrate the hepatic functions. | 03-31-2011 |
20110104742 | INTEGRATED SEQUENTIAL SAMPLE PREPARATION SYSTEM - The invention provides an integrated sequential sample preparation system using a sequential centrifuge for preparing samples for analysis. Methods of more efficiently preparing discrete samples sequentially for subsequent analysis are also provided. The apparatus and methods for sequentially preparing discrete samples provide improved operating efficiencies over conventional preparation processes that use batch centrifugation systems. Such advantages include reducing dwell time, increasing system throughput, reducing sample preparation system footprint, and improving precision of the analytical process. The integrated sequential preparation system with the integrated sequential centrifuge further provides the capability of handling critical or STAT samples without compromising the operating efficiencies achieved by preparing discrete samples in a sequential manner. | 05-05-2011 |
20110124037 | Method and Device for Automated Removal of Cells and/or Cell Colonies - The method comprises an automated removal of cells and/or cell colonies from a cell culture whilst executing a first detection step for selecting cells and/or cell colonies with reference to corporeal and/or physical parameters and detecting position data and storing the detected position data of the selected cells and/or cell colonies in a position database. | 05-26-2011 |
20110129870 | Microbial Screen Test - A method for testing a microbial population including a negative screen includes inoculating a plurality of test ampoules with respective samples and recording a time of the inoculation ( | 06-02-2011 |
20110171682 | SCREENING METHODS EMPLOYING INSECTS WITH BLOOD BRAIN BARRIER - There is provided insect models that are aimed to reflect vertebrate blood-brain barrier (BBB) penetration. Investigation of BBB penetration is extremely important in drug discovery; successful CNS drugs have to cross the BBB, while BBB penetration may cause unwanted side effects for peripheral acting drugs. Specifically, the present invention relates to the use of insects in screening for substances with a biological effect on the brain or central nervous system and/or effect on a disease or disorder of the brain or central nervous system. It further relates to use of such insects in screening for substances that have a desired biological activity and which do not cross the blood brain barrier. | 07-14-2011 |
20120088264 | METHODS FOR DETERMINING EFFICACY OF CHEMOTHERAPEUTIC AGENTS - An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying the best treatment or agent for the particular patient. Specific method innovations such as tissue sample preparation techniques render this method practically as well as theoretically useful. By subjecting uniform samples of cells to a wide variety of active agents (and concentrations thereof), the most promising agent and concentration for treatment of a particular patient can be determined. | 04-12-2012 |
20130017568 | Inoculation Loop Devices Having an Angled End and Methods of Making and Using the Same - Inoculation loop devices having an angled end are disclosed. Methods of making and using inoculation loop devices having an angled end are also disclosed. | 01-17-2013 |
20130059326 | Membrane Transfer Method And Tool - A method for transferring a filter membrane ( | 03-07-2013 |
20130065268 | Automatic device and method for inoculating a sample at different concentrations - An automatic device for inoculating a sample on a substrate with a dilution mechanism formed by a head that holds a stylus in cooperation with a first dilution tank and a second dilution tank to dilute an original sample in at least one sub-sample and for inoculating the sub-sample on a substrate. | 03-14-2013 |
20130089886 | METHOD FOR DIRECT AND RAPID IDENTIFICATION OF MICROORGANISMS AND ANTIMICROBIAL SUSCEPTIBILITY TESTING FROM POSITIVE BLOOD CULTURES - Methods of the invention include the isolation of intact, viable microorganism(s) from positive blood culture (“PBC”) samples for use in downstream analyses such as identification and antimicrobial susceptibility testing (“AST”). The methods involve collecting a portion of the PBC sample, adding a choline-containing solution, lysing the blood cells, isolating the viable microorganism, and performing downstream analysis of the isolated, viable microorganism. The methods can be applied to a variety of gram-positive bacteria, gram-negative bacteria, and/or yeast, and particularly to strains of | 04-11-2013 |
20130130301 | MICROFLUIDIC PLATFORM FOR DISCRETE CELL ASSAY - A microfluidic chamber for use in individual cell assays. The microfluidic chamber includes a cell microchamber having an interior region and front and rear valves, each of which are separately controllable so that they can be selectively opened and closed to thereby permit the transference of an individual cell into and out of the interior region. Cell secretion and contact interaction studies can be carried out using the microchambers, with the valves permitting either complete isolation or perfusion media flow through the microchambers. An internal perfusion wall can be included to partition the microchamber for non-contact perfusion studies of secretion interactions between cells. | 05-23-2013 |
20130130302 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA - The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials and methods for removing aurintricarboxylic acid (ATA) from a sample. | 05-23-2013 |
20130137133 | ULTRASONIC DISSECTION DEVICE AND ULTRASONIC DISSECTION METHOD - There is provided an ultrasonic dissection device for relatively removing a target biological object from other biological objects, the ultrasonic dissection device including an ultrasonic wave generation unit, an ultrasonic wave convergence unit, and a controller to control the ultrasonic wave generation unit. | 05-30-2013 |
20130260410 | MICROPLATE SAMPLING ADAPTER - The present invention relates to adapters for microplates. The adapters allow sampling from a liquid growth medium in a microplate well after a microorganism has formed a dense layer of biomass on the surface of the growth medium. The adapters also allow easy transfer of a surface-grown microorganism from all wells of a microplate in one go, when inserted before the microorganism form the layer and then removed after incubation and layer-formation, which also enables easy sampling of the growth medium in the | 10-03-2013 |
20130273591 | ON-DEMAND MICROFLUIDIC DROPLET OR BUBBLE GENERATION - Microfluidic systems and methods can dispense single or multiple fluid particles (such as a gas or other fluid bubble) or an encapsulated particle (e.g., a bead or biological cell) into a microchannel. | 10-17-2013 |
20130273592 | METHOD FOR ISOLATING A SAMPLE WELL OF A TEST CARD FOR ANALYSIS, AND RESULTING TEST CARD - The invention relates to a method for isolating at least one fluid sample well laid out in a test card for analyses, said test card including a plate ( | 10-17-2013 |
20130288291 | METHOD FOR COLLECTING A SAMPLE OF MICROORGANISMS FROM THE SURFACE OF A SOLID MATERIAL USING A CONTACTLESS PARTITIONING SYSTEM, AND APPARATUS FOR PARTITIONING THE SURFACE OF THE SOLID MATERIAL - The present invention relates to an apparatus for partitioning a sampling region on a solid surface and a method for collecting a microbial sample from a solid surface, in which an optimal sampling region is partitioned on a solid surface using a light source without bringing the solid surface into direct contact with a ruler or a partitioning tool. With the apparatus and method, a solid surface can be prevented from being contaminated during partitioning process, accuracy of sampling operation can be increased, partitioning operation can be continuously performed in a simple manner, and cost of sampling operation can be reduced. | 10-31-2013 |
20130288292 | SURFACE-TENSION BASED FLOW GUIDANCE IN A MICROSTRUCTURE ENVIRONMENT - This invention relates to a device and method for engineering microchannel geometries to take advantage of surface tension to guide fluid location. This technology may be used to construct compartmentalized systems of various materials that are added in liquid state, and may be used in a liquid state, or may be solidified, gelled, cross-linked, polymerized, or alternatively may be accumulated through gravity (e.g. cell settling), or centrifugation. | 10-31-2013 |
20130295600 | Process analysis system with sterile sampling of mechanically-sensitive material from a bioreactor - Method for transport of suspensions containing mechanically sensitive material with a sample-transporting device comprising transport conduits and at least one system for accelerating a sample or aliquot through the transport conduit from at least two burets. | 11-07-2013 |
20130302848 | DEVICE AND METHOD OF TAKING SAMPLES FROM MEDICAL EQUIPMENT FOR THE PURPOSE OF MICROBIOLOGICAL TESTING - A device and method for use in taking a sample from an item of medical equipment for the purpose of microbiological testing. The device includes attachment mechanism for attaching about a region of the item of medical equipment in an air-tight manner; and collection mechanism for collecting fluid which emanates from the item of medical equipment. | 11-14-2013 |
20130309711 | PREPARING BLOOD SMEARS ON A FIBER SURFACE - The present application discloses methods and apparatus for preparing blood film or smear samples on a fiber surface, staining the test sample, and generating digital cell images of the films or samples for classification and review. The techniques disclosed herein replace conventional microscope slides with fibers when preparing blood film test samples. Using fibers to prepare blood test samples facilitates automation and integration of the various processes involved in hematology analysis. The techniques disclosed herein can be used to improve the accuracy and efficiency of hematology analysis. | 11-21-2013 |
20130323778 | PAPER SUPPORT AND METHOD OF RECOVERING BIOLOGICAL MATERIAL THEREFROM - The present invention relates to paper supports for neonatal screening that are used for the storage and further processing of biological materials. The invention is particularly concerned with paper supports which have at least one surface coated with a chemical that enhances the recovery of the biological material from the support. Methods of preparing and using the paper supports are also described. | 12-05-2013 |
20130337489 | Method for Improved Detection of Microorganisms and the Like - A method is provided of applying a test sample to a fibrous pad containing growth media which uses unaccelerated dispersion and deposition of the microorganism. | 12-19-2013 |
20140011229 | FILTER SEPARATION METHOD AND FILTER SEPARATION APPARATUS USED FOR THE SAME - In a microorganism capturing device as a filter separation apparatus, a first contact chamber and a second contact chamber in each of which an object to be treated is contacted with a treatment agent are disposed apart from each other by a hydrophilic filter. The second contact chamber and a filtrate outlet are separated from each other by a hydrophobic filter. The microorganism capturing device is adapted to efficiently contact the object to be treated with the treatment agent, even if the object to be treated enters into the hydrophilic filter. | 01-09-2014 |
20140017720 | DEVICE FOR THE COLLECTION, REFINEMENT, AND ADMINISTRATION OF GASTROINTESTINAL MICROFLORA - Methods and systems for isolating gastrointestinal microflora from stool collected from a donor are provided. Stool is collected from a donor in a container as the donor is defecating. A solvent is introduced into the container and the container sealed to place its contents in a sealed environment. Various agents can be added to achieve dissolving, colorizing, deodorizing, or for further therapies. The solvent and collected stool is homogenized into a mixture which is then filtered by a multi-stage filter system to create a solution containing microflora in the desired consistency. This solution can be dispensed via an enema tube or other delivery apparatus for infusion into a patient's gastrointestinal tract. | 01-16-2014 |
20140038226 | Device For Spraying A Reagent For Fast Microbiological Analysis - The device for spraying a reagent onto a support ( | 02-06-2014 |
20140038227 | APPARATUS AND METHOD FOR PREPARING CYTOLOGICAL SPECIMENS FOR ANALYSES - The apparatus ( | 02-06-2014 |
20140038228 | REMOVABLE LAYER AND METHOD OF USE - A method of processing a sample for analysis is disclosed. The method includes providing a first sample-transfer article with a sample disposed therein, a container ( | 02-06-2014 |
20140051111 | METHOD FOR CONTINUOUSLY REGULATING FLUID PRESSURE - A method of continuously regulating fluid pressure of a first fluid in a fluid flow path by continuously adjusting at least one fluid flow characteristic of a second fluid flow which is engaged with the first fluid flow through a flexible barrier. | 02-20-2014 |
20140057314 | METHODS AND COMPOSITIONS FOR DETECTING MICROBIAL PRODUCTION OF WATER-IMMISCIBLE COMPOUNDS - Provided herein are methods and compositions useful for detecting the production of compounds in a cell, for example, a microbial cell genetically modified to produce one or more such compounds at greater yield and/or with increased persistence compared to a parent microbial cell that is not genetically modified. In some embodiments, the methods comprise contacting a solution with a fluorescent dye that directly binds the recombinantly produced compound, wherein the solution comprises a plurality of cells recombinantly producing the compound; and detecting the fluorescent dye under spectral conditions suitable for the selective detection of the fluorescent dye bound to the recombinantly produced compound. | 02-27-2014 |
20140072997 | SYSTEM AND METHOD FOR DEPOSITING PARTICLES ON A DISC - A system and method are disclosed in which particles sorted by a flow cytometer may be deposited directly into a deposition layer formed on the surface of an optical disc, and information regarding measurements made of the particle, as well as the storage location of the particle, can be written to the recording layer of the optical disc. | 03-13-2014 |
20140072998 | SYSTEM AND METHOD FOR AUTOMATICALLY VENTING AND SAMPLING A CULTURE SPECIMEN CONTAINER - Apparatus for automated venting and/or sampling of a specimen container having a closure sealing the interior of the specimen container from the environment is disclosed. The apparatus includes a rack holding the specimen container; a venting and/or sampling device having a needle, a chamber in fluid communication with the needle and a port in fluid communication with the chamber; a robotic transfer mechanism moveable relative to the rack; a sample removal apparatus attached to the robotic transfer mechanism having gripping features for gripping the venting device. The sample removal apparatus and robotic transfer mechanism are moveable relative to the specimen container so as to automatically insert the needle of the venting device through the closure of the specimen container to thereby vent the interior of the specimen container and obtain equilibrium between the interior of the specimen container and the atmosphere and withdraw a portion of the sample from the specimen container into the venting and/or sampling device. | 03-13-2014 |
20140093908 | SAMPLE PREPARATION APPARATUS AND SAMPLE PREPARATION METHOD - A sample preparation apparatus is provided. The apparatus comprises a first receiving part, a second receiving part, a filter part, a third receiving part, a flow path, a first moving means and a second moving means. The first receiving part is configured to accept a pipette and to receive a sample discharged from a pipette. The second receiving part is disposed at a position removed from the first receiving part in the plane of view. The filter part is configured to retain the cells to be analyzed within the second receiving part. The third receiving part is disposed opposite the second receiving part through the filter part The flow path is configured to connect the first receiving part and the second receiving part The first moving means is for moving a sample that has been received at the first receiving part to the filter part through the flow path and the second receiving part, and moving the components other than the cells to be analyzed to the third receiving part through the filter part. The second moving means is for moving the cells to be analyzed in the second receiving part from the second receiving part to the first receiving part. | 04-03-2014 |
20140093909 | POLYCATIONIC QUATERNARY AMMONIUM POLYMER COATINGS FOR IMMOBILIZING BIOLOGICAL SAMPLES - The present invention is directed to a pre-coated substrate, such as a slide, that is useful for immobilizing a sample. The invention is further provides methods of preparing such pre-coated substrates and methods of analyzing biological samples immobilized on such pre-coated substrate. The substrate is coated with a polycationic polymeric coating material specifically selected such that that coated substrate exhibits increased stability and prolonged shelf-life. Preferred polymeric coating materials include allylic or vinylic polymers having cationic groups thereon and having no more than a small percentage of peptidic monomeric linkages, particularly polydiallyldimethylammonium (PDDA). | 04-03-2014 |
20140106394 | MULTIWELL PLATE AND METHOD OF ANALYZING TARGET MATERIAL USING THE SAME - Provided is a multiwell plate for an easy liquid removal, wherein the mutiwell plate includes a well with at least one pore in the sidewall defining the well, and a method of analyzing a target material using the multiwell plate. | 04-17-2014 |
20140127741 | METHOD OF COLLECTION, CLASSIFICATION AND PRESERVATION OF SAMPLES CONTAINING STEM CELLS - A method of collection, classification and conservation of stem cells comprises the following steps: taking a sample of organic material by continuously maintaining a total microbiological, atmospheric and physical isolation between a sampling volume, the sample and a collection portion w herein the sample is confined, manipulating said sample under sterility conditions by an isolator apparatus, for determining a presence and/or an amount and/or developing capabilities of stem cells trapped in said sample and preserving the sample; the steps of taking the sample, manipulating the sample and preserving the sample are performed on a sample comprising at least a portion of organic tissue wherein stem cells are trapped in and are also performed on the sample in its entirety, without separating the stem cells from the portion of organic tissue. | 05-08-2014 |
20140154734 | SYSTEM AND METHOD FOR HIGH THROUGHPUT TISSUE SAMPLE EXTRACTION - Systems, methods, and devices involving tube carriers adapted for compatibility with 96-well format shorten and automate fluid handling during homogenization, extraction, or other processing of biological samples for high throughput analysis. | 06-05-2014 |
20140170697 | FLOW CELL - A flow cell for particle processing such as particle sorting, may be operatively engaged to a particle processing apparatus. The fluid contact surfaces of the flow cell may be fully enclosed. Further, the flow cell may encapsulate all fluid contact surfaces in the particle processing apparatus. The enclosing or encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The flow cell may employ any suitable technique for processing particles. The flow cell may be disposable and suitable for use in droplet sorting. The flow cell may include an operatively sealed sort chamber having a particle stream focusing region, an orifice, an interrogation zone and a sorting region. | 06-19-2014 |
20140178921 | APPARATUS AND PROCESS FOR ISOLATING SPECIFIC PHYSICAL ITEMS WITHIN A SET OF PHYSICAL ITEMS - Embodiments described herein provide an improved process for enriching, identifying, searching, separating and/or isolating target cells within a sample cell mixture using iterative enrichment or progression of the target cell, as well as some related methods and apparatuses. Two embodiments are microfluidic devices with multiple chambers into which a populations of cells are iteratively divided until a cell producing a target molecule is identified. Another embodiment is a faster and more broadly applicable process for the isolation of molecule producing cells comprising a series of laboratory methods for iterative enrichment. Some embodiments are directed to the process of directed evolution of cells secreting a target molecule. Another embodiment comprises a process for fast the identification of chemicals with specific properties through testing of combinations of items. | 06-26-2014 |
20140206034 | ELECTROKINETIC DEVICE FOR CAPTURING ASSAYABLE AGENTS IN A DIELECTRIC FLUID - Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. The agents are directed by creation of an electrokinetic potential well, which will affect their capture on to an assay device. The dielectric fluid medium, such as air, is sampled by electrokinetic propulsion with no moving parts or optionally, by transporting the dielectric fluid by a fan, pump or by breath. | 07-24-2014 |
20140212914 | Method for Purifying Certain Cell Populations in Blood or Bone marrow by Depleting Others - A method for purifying and harvesting certain cell populations in blood or bone marrow by depleting at least one of red blood cells, granulocytes, or platelets from a sample comprising blood, bone marrow, or stromal vascular fraction cells separated from adipose tissue is disclosed. The apparatus comprises a sterile, single use rigid, self-supporting cartridge within which the automated depletion, purification and harvesting of target cell populations occurs and all components may be distributed. | 07-31-2014 |
20140220616 | METHODS FOR INOCULATING CULTURE MEDIA ON PETRI DISHES BY MEANS OF VIBRATION FREQUENCIES - The present invention relates to a method for inoculating at least one agar culture medium, contained in a Petri dish, with at least one sample likely to contain microorganisms. The method includes the steps of: providing at least one agar culture medium contained in a Petri dish; providing the sample likely to contain microorganisms in liquid form; performing at least one deposition of the liquid sample onto the lid of the Petri dish such that the liquid sample can be transferred from the lid to the agar culture medium; and spraying the liquid sample, initially deposited onto the cover, onto the agar culture medium by vibrating the Petri dish. | 08-07-2014 |
20140234891 | Cards for Sample Storage and Delivery Comprising Sintered Porous Plastic - This application discloses cards comprising sintered porous plastic which may be employed in liquid sample collection, storage, transport and/or delivery to an analytical device. Sintered porous plastic materials provide a unique porous structure, an inert substrate, precise liquid holding capability, are quick drying, and easy to cut and handle. | 08-21-2014 |
20140234892 | MICROFLUIDIC DEVICE FOR SEPARATING CELLS FROM A FLUID - A microfluidic device for separating one or more cells having a diameter and a first surface energy from a bulk fluid having a second surface energy. The microfluidic device has a base portion having a capillary gap with an inlet capillary, an outlet capillary, a bottom surface, a gap height with the ratio of the gap height to the diameter of the one or more cells ranging from 5 to 1 to 100 to 1. The base portion defines a first flow path therethrough, at least one groove formed in the bottom surface of the capillary gap, the at least one groove having a depth, a width, and a third surface energy, and oriented perpendicular relative to the first flow path. The ratio of the groove width to the diameter of the one or more cells ranges from about 5 to 1 to about 100 to 1, and the third surface energy is higher than the first and second surface energies. | 08-21-2014 |
20140248656 | ANALYSIS AND SORTING OF MOTILE CELLS - A method for sorting motile cells includes introducing an initial population of motile cells into an inlet port of a microfluidic channel, the initial population of motile cells having a first average motility; incubating the population of motile cells in the microfluidic channel; and collecting a sorted population of motile cells at an outlet port of the microfluidic channel. The sorted population of motile cells has a second average motility higher than the first average motility. | 09-04-2014 |
20140255976 | CAPTURE, PURIFICATION, AND RELEASE OF BIOLOGICAL SUBSTANCES USING A SURFACE COATING - This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance. | 09-11-2014 |
20140255977 | CELL COLLECTION APPARATUS AND CELL COLLECTING METHOD - Provided is a cell collection apparatus includes: a supporter that supports a sheet to which a back surface of a substrate is pasted, the substrate being divided in to plural small pieces with a section of a tissue pasted on a front surface thereof; a needle including needle tips; and a holder that is configured to hold the needle with the needle tips facing the sheet on an opposite side to a substrate side of the sheet, and to move the needle in the forward direction of the needle tips, wherein at least two needle tips are arranged within a region narrower than the back surface of the small piece substantially on the identical plane intersecting with the longitudinal direction of the needle. | 09-11-2014 |
20140255978 | TISSUE DIVIDING APPARATUS, TISSUE DIVIDING METHOD, AND CELL COLLECTING METHOD - The present invention divides a section of a biological tissue into fragments in a size of including a sufficient amount of cells with a simple structure and a simple operation. The present invention provides a tissue dividing apparatus including: a substrate dividable into a plurality of small pieces, and having a surface to which a section of a biological tissue can be pasted; and a dividing unit that divides the substrate into a plurality of small pieces, and thereby divide the section pasted on the surface into fragments each having a substantially equivalent shape to a shape of each small piece. | 09-11-2014 |
20140273070 | ASPIRATION-FREE WELL PLATE APPARATUS AND METHODS - A well plate includes a including a top portion, a bottom portion and a membrane disposed between the top portion and the bottom portion. The top portion defines a sample well in fluid communication with an opening defined by the membrane and in fluid communication with a reservoir defined by the bottom portion. The well plate is configured to be used in a centrifugation process of a test sample including a sample material and a wash liquid. The test sample configured to be received within the sample well and the reservoir. The membrane configured to filter the wash liquid from the test sample during the centrifugation process such that the wash liquid can pass from the reservoir, through the membrane and can be captured within a collection chamber while the sample material remains within the reservoir. | 09-18-2014 |
20140273071 | AUTOMATED SPECIMEN TRANSFER SYSTEM AND METHOD - An automated sample processing system includes a sample input adapted to receive at least one sample container holder manually provided by a user, a consumable input adapted to receive one or more unused consumable supplies manually provided by a user, a waste output adapted to receive used consumable supplies, an automated processing apparatus, and a sample output, wherein the automated processing apparatus includes a decapper adapted to remove a lid from the at least one sample container, at least one agitator adapted to agitate and thereby homogenize the contents of the at least one sample container, a sample collector adapted to remove fluid specimen from the at least one sample container and transfer the specimen to at least one output carrier, and a capper adapted to replace the lid on the at least one sample container. | 09-18-2014 |
20140322745 | OPTICAL METHOD FOR CONTROLLING THE MOVEMENT OF A SAMPLING TOOL - The present invention relates to a method of sampling biological material on a reference surface, such as the surface of an agar medium, with the aid of a sampling tool, said method making it possible to steer the displacement of the sampling tool towards the reference surface, from a first position towards a second position, and/or of the reference surface towards the sampling tool, from a first position towards a second position, said second position being a contact position in which the sampling tool and the reference surface are in contact, said method comprising the following steps:
| 10-30-2014 |
20140329269 | DEVICES, SYSTEMS, AND METHODS FOR EXTRACTING A MATERIAL FROM A MATERIAL SAMPLE - Devices, systems, and associated methods for selectively extracting a material from a sample are provided. In one aspect, for example, a method for selectively extracting biological material from a biological sample can include identifying a region of biological material to be extracted from a biological sample disposed on a substantially planar surface, applying an extraction tool to the region of biological material to disrupt biological material from the biological sample, and dispensing a liquid at the region of biological material. The method can also include aspirating the liquid and the disrupted biological material from the biological sample. | 11-06-2014 |
20140329270 | AUTOMATED SYSTEM AND METHOD OF TREATING TISSUE SAMPLES ON SLIDES - An automated method and system for treating one or more tissue samples disposed on slides, the system comprising: a controller, a plurality of slide treatment modules arranged to receive ones of the slides; at least one fluid dispensing robot configured by the controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules via an output nozzle disposed on the at least one fluid dispensing robot to treat said one or more tissue samples respectively; and at least one pumping means for pumping said reagents to the output nozzle of the at least one fluid dispensing robot from a plurality of reagent containers comprising said reagents, wherein the at least one fluid dispensing robot is configured by the controller to dispense said reagents in a predetermined sequence for each of the slide treatment modules to treat the one or more tissue samples disposed on each of the slides independently. | 11-06-2014 |
20140342394 | MUSCLE CHIPS AND METHODS OF USE THEREOF - The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for these assays. | 11-20-2014 |
20140342395 | OPTICAL PROJECTION TOMOGRAPHY MICROSCOPY (OPTM) FOR LARGE SPECIMEN SIZES - Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube. | 11-20-2014 |
20140356898 | DEVICES AND METHODS FOR OVERLAYING BLOOD OR CELLULAR SUSPENSIONS - A device is described that overlays a first fluid, such as blood or a cellular suspension onto a base material, such as a density gradient. In some embodiments, the fluid layering device includes a cylindrical reservoir, a fluid barrier, a coupling extension, a plunger, and an exhaust vent. The fluid layering device can be coupled through its coupling extension to an open end of a container, such as a conical centrifuge tube, including the density gradient. Once attached, the plunger may be lowered to a position above the surface of the density gradient. A first fluid may flow from the reservoir into the conical tube across the plunger, so that a suitable overlay is formed without substantially disturbing a surface of the density gradient. The plunger may be buoyed upward by the first fluid during operation, providing a constant regulation of flow throughout overlaying, regardless of the care and skill of the user. | 12-04-2014 |
20140370540 | METHODS FOR OBSERVING SAMPLES AND PREPROCESSING THEREOF - Disclosed is a method for enabling flexibility of the exoskeletons or joints of aquatic organisms immersed in an ion liquid water solution to be maintained without destroying their original forms by reducing the difference in osmotic pressure between the inside and outside of the aquatic organisms, preventing dehydration of biological samples. First, the aquatic organism is put into a low-concentration ionic liquid to increase continuously the concentration of the ionic liquid, enabling the water content of the aquatic organism to be substituted by a high-concentration ionic liquid in their original forms. The use of the increasing method that gentle increase in temperature of the ionic liquid by means of natural seasoning reduces the osmotic pressure difference between the inside and outside of the aquatic organism, increasing the concentration of the ionic liquid inside of the aquatic organism. | 12-18-2014 |
20150010939 | Flow Cytometric Systems for Sterile Separation of Magnetically Labeled Sample Components - Systems for sterile separation of magnetically labeled sample components and methods for using the same are provided. Embodiments of the systems include a magnetic separation device and a pliant sample container, where a portion of the pliant sample container is operatively coupled under pressure to the magnetic separation device. Also provided are methods of using the systems, as well as pliant sample containers configured for use with the subject systems and methods. | 01-08-2015 |
20150017678 | Systems, Devices, and Methods for Separating, Concentrating, and/or Differentiating Between Cells from a Cell Sample - Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto. | 01-15-2015 |
20150017679 | THIN SECTION FABRICATION APPARATUS AND METHOD OF FABRICATING THIN SECTION - A thin section fabrication apparatus includes an epi-imaging data acquisition unit that performs imaging by radiating epi-illumination and acquires imaging data, a diffusion imaging data acquisition unit that performs imaging by radiating diffusion illumination and acquires imaging data, an exposed shape extraction unit that extracts an exposed shape of an exposure portion of the biological sample which is exposed to a surface of the embedding block, based on the imaging data acquired by the epi-imaging data acquisition unit, an embedded shape extraction unit that extracts an embedded shape of an embedding portion of the biological sample which is embedded in the embedding block, based on the imaging data acquired by the diffusion imaging data acquisition unit, and a control unit that determines ending of the preliminary cutting by comparing the exposed shape extracted by the exposed shape extraction unit and the embedded shape extracted by the embedded shape extraction unit. | 01-15-2015 |
20150024427 | SOLUTION AND METHOD FOR ADHERING SUSPENSION COMPONENTS TO A SUBSTRATE - This disclosure is directed to a method and an attachment solution for adhering a cytological or histological sample, such as buffy coat, to a substrate, such as a microscope slide. The attachment solution includes an attachment base and an anti-coagulant. The attachment base may be an alcohol, an acid, an oxidizer, an organohalogen, a ketone, such as acetone, or any combination thereof, such as Carnoy's solution. Once a sample is obtained, the sample may be re-suspended in the attachment solution or the attachment solution may be added to the sample. The sample may then be dispensed onto an analysis platform as one or more droplets and cured. The sample may be spread on the analysis platform after having been dispensed. The sample may then be fixed, permeabilized, labeled, blocked, and washed. The sample may then be imaged and analyzed. | 01-22-2015 |
20150031071 | Method and System for Distributing and Agitating an Amount of Liquid Over a Microscope Slide - A system and method for distributing and agitating an amount of a liquid over a microscope slide, wherein a distribution plate having a microtextured lower surface and at least one passage extending through the plate is secured at a predetermined distance of 10-250 μm above the microscope slide. Liquid passes through the passage in the distribution plate, and the distribution plate is transversely reciprocated relative to the microscope slide in the plane of the lower surface of the distribution plate or the plane of the upper surface of the microscope slide. | 01-29-2015 |
20150031072 | SAMPLE TAKING DEVICE - Sample taking device for extracting a fluid sample from a vessel comprising: a cover portion for closing the vessel such that, in use a headspace is defined between the cover portion and fluid held in the vessel, a sampling chamber comprising a sampling inlet and a sampling outlet, a cannula adapted to provide, in use, fluid communication between the fluid held in the vessel and the sampling chamber through the sampling inlet, and ports to operate the device in at least two operating conditions: a sample preparing condition in which a pressure in the headspace is greater than that of the sampling chamber such that fluid flows through the cannula towards the sampling chamber and can be retained therein, and a sample dispensing condition in which fluid retained in the sampling chamber can be delivered through the sampling outlet and fluid remaining inside the cannula can return to the vessel. | 01-29-2015 |
20150031073 | APPARATUS AND METHOD FOR BIOLOGICAL SAMPLE PROCESSING - An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples. | 01-29-2015 |
20150037833 | CONTAINER AND SYSTEM FOR SAMPLE COLLECTION AND PREPARATION - The present invention relates to a system for collecting and preparing a body fluid sample, the system comprising a sample container ( | 02-05-2015 |
20150064740 | SPECIMEN PROCESSING APPARATUS - The present invention is to present a specimen processing apparatus, comprising: an imaging device for imaging a cap of a covered specimen container containing a specimen; an aspirating device including a specimen aspirating tube, moving the specimen aspirating tube so as to pass the specimen aspirating tube through the cap of the covered specimen container and aspirating the specimen contained in the covered specimen container via the specimen aspirating tube; an aspiration controller for controlling a movement of the specimen aspirating tube into the covered specimen container based on an image obtained by the imaging device; and a specimen processing device for processing the specimen aspirated by the aspirating device. | 03-05-2015 |
20150079625 | NAPHTHALENE-BASED TWO-PHOTON FLUORESCENT PROBES, PREPARATION METHOD AND USE THEREOF - The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X | 03-19-2015 |
20150087010 | FILTER MEMBER AND A METHOD OF OBTAINING CELLS USING THE SAME - The present invention provides a filter member. The filter member comprises: a filter for discriminating cells to be analyzed in a sample from other components; a first filter holding member which comprises a first through hole and has a plate-like shape; and a second filter holding member which comprises a second through hole and is fitted into the first filter holding member. When the first and second filter holding members are integrated by fitting the second filter holding member into the first filter holding member, the filter is sandwiched between the first filter holding member and the second filter holding member, and the first through hole is opposed to the second through hole through the filter. A first elastic body is formed on a surface of the first filter holding member, the surface being in contact with the filter. A second elastic body is formed on a surface of the second filter holding member, the surface being in contact with the filter. | 03-26-2015 |
20150093774 | SENSORS AND METHODS FOR CAPTURE, KILLING, AND RELEASE OF BACTERIA - There is provided a renewable sensor for sensing or selectively capturing a targeted bacteria in a fluid. The renewable sensor includes a surface, the surface includes a substrate, a biologically or bacterially non-adhesive feature disposed on or in functional proximity to at least a portion of the substrate; and an adhesive elements disposed on or in functional proximity to the non-adhesive feature, a flow channel in operative contact with the surface; and a detector configured to detect the targeted cell type captured on the surface. Also provided are method for using the sensor and the surface. | 04-02-2015 |
20150104824 | Fixed Chamber Separator With Adjustment Withdrawal Member - A separation device that can include a separation tube or container that has a wall defining an internal volume into which a material can be placed is disclosed. The material can include a multi-component mixture or solution. A secondary tube or withdrawal cannula can be placed and/or moved within the tube to withdrawal a material form the tube. | 04-16-2015 |
20150104825 | CAPTURE, DISRUPTION, AND EXTRACTION APPARATUS AND METHOD - A cell capture, disruption, and extraction apparatus includes a disruption chamber configured to receive cell solution and having therein a plurality of abrasives, which can include diamond powder, variably and multi dimensionally disbursed therein, and a pestle positioned in the disruption chamber. The apparatus includes an actuation device configured to agitate the disruption chamber and/or pestle, movement of the abrasives tearing cell structure in the solution to access its contents. A binding column or size exclusion column can be positioned downstream of the disruption chamber. The pestle can rotate with respect to the disruption chamber. The pestle can include a nut-shaped core or axle, and/or include a plurality of extrusions. Cell solution can first be introduced in the disruption chamber, the abrasives capturing the cells and allowing therethrough and purging the waste content, then breaking the cell content through the foregoing agitation process. The lysate can then bind to an extraction matrix downstream of the disruption chamber or it can be mixed in with the abrasives. | 04-16-2015 |
20150111241 | INLET AND OUTLET GEOMETRIES FOR A VERTICAL THREE-STREAM MICROFLUIDIC DEVICE - An example includes an apparatus for separating cells from a fluid sample, including a plenum, defining: a centrally located top inlet, and respective side outlets disposed below the inlet and to the side of the inlet; and a bottom outlet disposed below the top inlet, to the side of the two or more outlets, wherein the plenum is configured to receive a fluid and cells suspension through the inlet, and direct it to the bottom outlet, against respective side-walls extending between the bottom outlet and the two or more side outlets, and wherein the distance between each of the two or more side outlets and the bottom outlet is selected to encourage cells to exit through the bottom outlet under a force. Lateral/vertical distance between the inlet and side outlets can provide lateral fluid travel, thereby allowing time for gravity to bias cells toward an outlet. | 04-23-2015 |
20150111242 | CELL COLLECTING APPARATUS AND METHOD OF USE - The present invention provides an apparatus and method for microdissecting a biological sample. In particular, apparatuses of the invention include a cell collecting device | 04-23-2015 |
20150118704 | METHOD FOR DELIVERY OF SMALL MOLECULES AND PROTEINS ACROSS THE CELL WALL OF ALGAE USING MOLECULAR TRANSPORTERS - The introduction of tools to study, control or expand the inner-workings of algae has been slow to develop. Provided are embodiments of a molecular method based on guanidinium-rich molecular transporters (GR-MoTrs) for bringing molecular cargos into algal cells. The methods of the disclosure have been shown to work in wild-type algae that have an intact cell wall. Developed using | 04-30-2015 |
20150125895 | FORMULATIONS AND PROCESS FOR ISOLATING VIABLE MICROORGANISM FROM POSITIVE BLOOD CULTURES - Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including | 05-07-2015 |
20150125896 | CELL BINDING PEPTIDES FOR DIAGNOSIS AND DETECTION - Cell binding peptides are provided for binding to cells including urothelial and thyroid follicular cells. The peptides are useful for detection and diagnosis of cancer including bladder and thyroid cancer. A device and method for using the device for capturing cells is provided, the device includes a support having attached cell binding peptide. The support can be a slide and the device can be used for detection and diagnosis of cancer including bladder and thyroid cancer. A kit is provided with instructions for capturing cells and a support with attached cell binding peptide for detection and diagnosis of bladder and thyroid cancer. | 05-07-2015 |
20150132793 | METHOD FOR FILTERING A BIOLOGICAL SAMPLE - A method for filtering a sample comprising the steps of: (a) providing a sample with eukaryotic cells and containing or suspected to contain a micro-organism; (b) performing a selective lysis of the eukaryotic cells to obtain a lysed sample; (c) filtering the lysed sample obtained in step (b) through a filter arranged to retain the micro-organism; (d) washing the filter with a detergent based wash buffer to selectively solubilize proteins originating from the eukaryotic cells retained by the filter, by passing the detergent based wash buffer through the filter, to remove protein clogs from the filter in order to allow an additional step (c) of filtering said lysed sample. | 05-14-2015 |
20150293133 | Automated Smear Making Apparatus - An automated smear making apparatus used to prepare and smear samples on glass slides. In one embodiment, there is provided a smearing subsystem that generally includes a smear cartridge having: an input reel; at least one roll bar; a take-up reel; and a smearing tape. The smearing tape is initially wound within the input reel and coupled to the take-up reel such that the smearing tape can be drawn from the input reel and into the take-up reel. The smearing tape may include a plurality of perforations formed therein. The smearing tape may then be wrapped around the roll bar such that each of the plurality of perforations forms a blade that extends from the smearing tape to expose a smear surface as the smearing tape is drawn into the take-up reel. Alternatively, the smearing tape may be bent such that an edge of the smearing tape forms a smear surface between two roll bars. A slide transport surface is also provided to move a slide across the smear surface. | 10-15-2015 |
20150299758 | MAGNETIC NANOPARTICLES - The present invention provides a method for producing a microscopic object comprising locating a microscopic structure, formed of an organic substance, to be used as a mold on a substrate, depositing an intended element on a surface of the organic structure by a vacuum vapor deposition method or the like, and then decomposing and thus removing the organic structure as the mold by an ultraviolet-ozone process or the like to obtain the microscopic structure formed of only an intended element. | 10-22-2015 |
20150300931 | SLIDE TRANSPORT SYSTEM - A slide transport system for an automated slide treatment apparatus having slide treatment modules for receiving slides and a fluid dispensing robot configured by a controller to dispense reagents to the slides is disclosed. The slide transport system includes a slide transport robot configured by the controller to move the slides to and from the slide treatment modules and a slide transport device disposed on the slide transport robot and configured by the controller to releasably hold the slides. A slide handling head on the slide transport robot moves a closure body of a slide treatment module from a normally closed to an open position to move slides in the slide treatment module. The slide transport device is configured by the controller to release a slide when located in the slide treatment module, when the closure body is in the open position. | 10-22-2015 |
20150307915 | DETECTION OF OLIGOSACCHARIDES - Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation. | 10-29-2015 |
20150309038 | METHOD AND DEVICE FOR MARKING ISOTOPES - The present invention relates to an isotope labeling chamber for labeling metabolites in an organism, comprising a reactor chamber ( | 10-29-2015 |
20150309054 | METHOD FOR DETECTION OF AGGREGATES IN BIOLOGICAL SAMPLES - The present invention provides a method for detecting protein aggregates in a biological sample, and uses thereof. | 10-29-2015 |
20150314285 | FILTRATION DEVICE - A device for collecting cellular material from a fluid sample comprises first and second chambers that are releasably connected and which define a fluid flow path from the first chamber to the second chamber. A porous membrane is between the chambers when they are connected to each other, in the fluid flow path. An absorbent body is positioned in close proximity to the downstream surface of the porous membrane, and a resilient member is arranged to urge the absorbent body towards the porous membrane. In use, a sample introduced into the first chamber contacts the upstream surface of the porous membrane and fluid is drawn through the porous membrane and is absorbed by the absorbent body. Cellular material is retained upon the upstream surface of the porous membrane. After separation of the chambers, the porous membrane can be removed from the device for analysis of the deposited cellular material. | 11-05-2015 |
20150316456 | ISOLATION AND CHARACTERIZATION OF TUMOR CELLS USING SHEAR STRESS MEASUREMENTS - Methods for isolating viable cancer cells from a sample that comprises a mixture of cancerous cells and normal (non-cancerous) cells are provided. In the methods, a fluid preparation comprising a mixture of cancerous and normal cells is repeatedly exposed to fluid shear stresses, whereby the repeated exposure to the fluid shear stresses preferentially imparts fluid shear stress-resistance to the cancerous cells. | 11-05-2015 |
20150323426 | SUCTION TIP, OBJECT OBSERVATION DEVICE USING THE SUCTION TIP, AND OBJECT OBSERVING METHOD - A suction tip, an object observation device and an object observing method using the suction tip. The suction tip is provided with an internal tubular passage serving as a suction path for sucking an object, a distal end portion disposed in a substantially vertical direction when in use and including a suction port for sucking the object, the suction port being an opening formed in one end of the tubular passage; and a trap portion formed downstream of the distal end portion in a suction direction, and configured to trap the object to be sucked through the suction port. According to the suction tip, the object observation device and the object observing method using the suction tip, it is easy to collect the object, without falling and discharging of the collected object in the gravitational direction. | 11-12-2015 |
20150336097 | MICROFLUIDIC CHIP HAVING ON-CHIP ELECTRICALLY TUNABLE HIGH-THROUGHPUT NANOPHOTONIC TRAP - In one implementation, a microfluidic device based on optical trapping of particles is disclosed to include a substrate structured to include a fluidic channel which can carry a fluid having particles; and an optical waveguide loop formed on the substrate to include one or more waveguide sections that reside within the fluidic channel, an input optical port for the optical waveguide to receive an input optical beam, and an optical power splitter coupled to the optical waveguide loop to split the received input optical beam into two counter-propagating optical beams that prorogate in the optical waveguide loop in opposite directions and interfere with each other to form standing optical waves in at least the one or more waveguide sections that reside within the fluidic channel to optically trap particles at or near a surface of the one or more waveguide sections that reside within the fluidic channel. This device further includes an electrically controllable phase control device formed on the substrate and coupled to a location of the optical waveguide loop and operable to control an optical delay experienced by guided light at the coupled location, wherein the electrically controllable phase control device is configured to respond to an electrical control signal to adjust an amount of the optical delay at the coupled location to cause a shift in locations of nodes of each optical standing wave to change trapping locations of the trapped particles in the fluidic channel. | 11-26-2015 |
20150337355 | CELL-SPREADING DEVICE AND METHOD FOR DETECTING RARE CELL - A cell-spreading device may include a microchamber chip having a microchamber capable of enclosing and retaining a cell, a channel-forming frame united with the microchamber chip to form a channel on the microchamber, an inlet provided in the channel-forming frame to allow a cell suspension to flow into the channel, and an outlet provided in the channel-forming frame to allow the cell suspension, which has been allowed to flow into the channel through the inlet, to flow out from the channel. When an aperture of the microchamber is projected perpendicularly to a longitudinal width of the microchamber chip, the void ratio that is a ratio of the sum total of voids to the longitudinal width is not more than 5%, the void being a length of a portion where the projected aperture of the microchamber is not present against the longitudinal width. | 11-26-2015 |
20150338321 | CELL PATHOLOGY TUBES AND ASSOCIATED CELL PROCESSING METHODS - Cell tubes that can be used both for pathology collection and subsequent cell processing include a tube with a cell bed at a lower portion of the tube. The tube can include a base member that can be detachable from the tube body. The tubes can be used to form cell (cytology) blocks that incorporate the cell bed. The cell bed can be an inert cell bed of paraffin. | 11-26-2015 |
20150352552 | MICROFLUIDIC DEVICE AND METHOD THEREOF - A microfluidic device includes a platform with a microstructure. The microstructure include a primary channel and a plurality of chambers that open to the primary channel to enable a sample fluid that is loaded into the device via the primary channel to flow into the chambers. Each chamber has a volume that is less than tens of nanoliters and is connected by a vent to a secondary channel of the microstructure. A width of the vent is configured to enable a gas to escape from the chamber to the secondary channel while inhibiting flow of the sample fluid from the chamber into the secondary channel. | 12-10-2015 |
20150361477 | MICROSTRUCTURE FOR CAPTURING AND RELEASING MICROORGANISM - Provided is a method for capture and release of microorganisms using microstructures. The method includes providing microstructures coated with a protein for attachment/detachment of microorganisms, mixing the microstructures with a solution containing substances assisting in attachment of microorganisms in a solution containing microorganisms to prepare a mixed solution, stirring the mixed solution to attach the microorganisms to the microstructures, separating the microorganism-attached microstructures from the mixed solution; and exposing the microstructures to an environment where the substances assisting in attachment of the microorganisms are present at a low concentration to detach the microorganisms from the microstructures. | 12-17-2015 |
20150369712 | METHOD FOR MEASURING OR IDENTIFYING A COMPONENT OF INTEREST IN A BIOLOGICAL SYSTEM - A method for measuring or identifying a component of interest in a biological system is disclosed herein. The method includes positioning a fibre within the biological system, the fibre being at least partially coated with a polymeric extraction phase for adsorbing the component of interest from the biological system, the extraction phase being positioned within the biological system; adsorbing the component of interest onto the extraction phase; removing the fibre from the biological system; inserting the fiber into a nanospray needle; flowing solvent through the nanospray needle; desorbing the component of interest from the extraction phase into the solvent; and nanospraying the desorbed component of interest into an analytical instrument for measurement or identification. | 12-24-2015 |
20150375228 | DEVICES FOR SORTING CELLS IN A SAMPLE AND METHODS FOR USE THEREOF - Devices for sorting cells in a fluid sample are provided. The device includes a microfluidic conduit configured to carry a flow of a fluid sample. The conduit includes a longitudinal divider extending from an interior surface of the conduit towards an opposing interior surface of the conduit, where the longitudinal divider defines a first longitudinal fluid flow path in fluid communication with a second longitudinal fluid flow path in the conduit. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic assays. | 12-31-2015 |
20160017274 | DEVICE AND METHOD FOR TREATING A FILTRATION MEDIUM | 01-21-2016 |
20160017401 | Method and apparatus for trapping and growing micro-organisms using pre-filter pads and similar pads - A method and apparatus for achieving optimum results of MF and/or Microtrap™ methods considering all of the basic elements that may be included in the MF and/or Microtrap™ apparatus with or without the need for a separate membrane filter and pad. In a major new addition to the classical MF and Microtrap™ approaches in the present invention, a different type of pad can be used to serve the function of both a pad and a membrane filter, (e.g. what is known in the industry as a “pre-filter”) through the use of fine mesh glass material for the pad, that material being non-toxic to the target micro-organisms (formed from fiberglass filaments, for example), with small openings (e.g. 0.3 to 0.7 micrometers). The pad may be pre-treated with growth media, preferably in dehydrated format, and formed of sufficient thickness to absorb and retain the sample fluid in which the target organisms are entrained. That fluid passing into the pad may, for example, function to activate the growth media so that it is available to the micro-organisms retained on the surface of the mesh. | 01-21-2016 |
20160018296 | Device and method for drawing a liquid from a process tank - A device for drawing a liquid from a process tank, in particular, a process tank to be protected from contamination, comprising: a first receptacle for receiving the liquid withdrawn from the process tank. A first liquid line, connecting the process tank with the first receptacle and having a first end that can be connected with the process tank and a second end opening into the first receptacle; and at least one first valve assembly, which is arranged between the first and second ends of the first liquid line and is designed to block or release liquid transport through the first liquid line. The device has at least one pressure sensor, which is connected with the first receptacle, in particular, for detecting a pressure prevailing within the first receptacle and/or is arranged at the second end of the first liquid line. The device is designed to transport liquid from the process tank to the first receptacle in a first operating mode, characterized in that the device is designed to block liquid transport from the process tank to the first receptacle in a second operating mode, wherein said device is designed such that a pressure difference (p | 01-21-2016 |
20160025604 | SYSTEMS AND METHODS FOR TRANSFER AND PROCESSING OF BIOLOGICAL SAMPLES - Systems and methods are described for transfer of tissue samples from a substrate to a vessel, for subsequent processing (e.g., focused acoustic treatment) within the vessel. A transfer apparatus, having a transfer end and a handle end, may be used to collect a sample material from the substrate. When the sample material is collected from the substrate, the transfer end may be placed within a vessel for treatment of the sample material while the transfer end is also located within the vessel. In some embodiments, the transfer end may be decoupled or otherwise separated from the handle end so that only the transfer end portion of the transfer apparatus is located within the vessel during treatment. | 01-28-2016 |
20160032348 | SEPARATION DEVICE FOR USE IN THE SEPARATION, CHARACTERIZATION AND/OR IDENTIFICATION OF MICROORGANISMS - The present invention is directed to a separation device or container that can be used in the separation, isolation or pelleting of microorganisms from a test samples known to contain or suspected of containing said microorganisms. Subsequently, the separated, isolated or pelleted microorganism sample can undergo one or more interrogation steps to provide measurements useful for the characterization and/or identification of microorganism. In one aspect of the present invention, the interrogation steps can occur in situ in the separation device or container described herein. | 02-04-2016 |
20160032350 | Microfluidic Microbe Detection and Isolation - A method and microfluidic device useful for isolating microbes from a blood sample which includes introducing the blood sample into the sample inlet of a spiral microfluidic device; and introducing a second fluid into the sheath inlet of the microfluidic device, wherein the spiral channel terminates in a microbe outlet and a waste outlet, and wherein the spiral channel includes a length, height, and a width that define an aspect ratio adapted to isolate any microbes present in the sample along a first portion of the spiral channel terminating at the microbe outlet, and to isolate red blood cells and leukocytes along a second portion of the spiral channel terminating at the waste outlet; and collecting the microbes from the microbe outlet, thereby isolating the microbes. | 02-04-2016 |
20160032351 | METHODS AND APPARATUS FOR HANDLING MICROBIAL SAMPLES - This invention pertains to the general field of microbiology, and more specifically to transfer, inoculation and/or streaking of micro-organisms, e.g. for the purpose of obtaining individual colonies. Provided is a method for transferring a microbial sample from a first carrier to a second carrier, comprising the steps of:
| 02-04-2016 |
20160041077 | APPARATUS, SYSTEM, AND METHOD FOR COLLECTING A TARGET MATERIAL - This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. A fraction-density-altering solution may be added to a vessel that contains the sample to change the density of a first fraction of the sample without changing the density of the target material or the density of any other sample fraction. A collector may be inserted into the vessel to funnel the target material from the sample into the collector or into a processing receptacle included in the collector. In one implementation, the collector may include a cannula which extends into a chamber to hold the processing receptacle at a first end of the collector and a funnel at a second end that that is in fluid communication with the cannula. In another implementation, the processing receptacle may be inserted into a bore within the collector. | 02-11-2016 |
20160047721 | Sample Acquisition System and Method of Use - A system for acquiring a fluid sample from a flow pipe, comprising a sampling probe placed within the flow pipe, a curved separating pipe in fluid communication with the sampling probe, the separating pipe having formed therein an inwardly-opening lengthwise channel along the outside curve thereof, the separating pipe terminating in a sample area, and a lengthwise inwardly-opening sample passage in fluid communication between at least a portion of the sample area and a sample port, the sample passage being formed substantially opposite the channel, whereby inertial effects induced in the separating pipe cause relatively higher density inorganic and dead organic material to funnel into the channel and out a non-sample drain formed in the sample area substantially opposite the separating pipe while allowing live organisms to navigate the sample passage and out the sample port. | 02-18-2016 |
20160061697 | Method and Apparatus for Pipette Tip Columns - An apparatus and method of using a pipette with pipette tip columns were developed in which a pipette is operated with the pipette tip columns inserted into the wells of a microplate. In this configuration the pipette is free standing and is essentially perpendicular to the microplate. The pipette is hand-held when transferring between positions, e.g., between operation steps that take place in different rows of wells. | 03-03-2016 |
20160061698 | METHOD OF COLLECTING OF RARE CELLS FROM THE ENCLOSED FILTERS SYSTEM - The methods of rare cells collection from enclosed micro filter system are provided. This invention includes surface treatment of the filter, application of cells dissociation reagent, shaking/vibration and back/side flush systems. | 03-03-2016 |
20160069861 | SENSORS AND METHODS FOR CAPTURING TARGETED CELLS - A sensor for selectively capturing a targeted cell type in a fluid includes an engineered surface. The engineered surface includes a substrate, a non-adhesive element disposed on at least a portion of a substrate, and an adhesive element disposed on the substrate. The sensor also includes a flow channel in operative contact with the engineered surface; and a detector configured to detect the targeted cell type captured on the engineered surface. Also described is a method for selectively capturing target cell types using the engineered surface. | 03-10-2016 |
20160076072 | IMAGING CARTRIDGE, PIPETTE, AND METHOD OF USE FOR DIRECT SPUTUM SMEAR MICROSCOPY - An assembly for preparing a specimen is provided that may be configured to determine the presence of at least one microorganism specie in the specimen. The assembly may include a pipette configured to acquire a specimen from a sample and an imaging cartridge configured to be in fluid communication with the pipette. The imaging cartridge and the pipette may be configured to be irreversibly coupled such that the specimen is bio-contained within the imaging cartridge and the pipette when the imaging cartridge and pipette are coupled together. Associated methods of use are also provided. | 03-17-2016 |
20160076073 | FIBER SAMPLER FOR RECOVERY OF BIOAEROSOLS AND PARTICLES - A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers formed into a fiber mat and configured to collect bioparticles thereon, and includes a viability enhancing material provider disposed in a vicinity of the plurality of fibers and configured to provide a viability enhancing material to the collected bioparticles to maintain viability of the bioparticles collected by the fiber mat. The aerosol collection system includes an aerosol pumping device configured to entrain particles in an gas stream, an aerosol saturation device configured to saturate the particles in the gas stream with a biocompatible liquid, and an aerosol collection medium downstream from the aerosol saturation device and including a plurality of fibers formed into a fiber mat for collection of the saturated aerosol particles. | 03-17-2016 |
20160083772 | DEVICE AND METHOD FOR DISPENSING A SUSPENSION OF MICROORGANISMS - A device including an applicator capable of dispensing a suspension of microorganisms on a culture medium and to the use of the device for dispensing the suspension of microorganisms. | 03-24-2016 |
20160083773 | Apparatus and Process for Treating Samples of Biological or Microbiological Material - An apparatus for treating samples includes a first housing interface ( | 03-24-2016 |
20160083774 | DEVICE FOR PATHOGEN TRANSPORT - This disclosure provides a method for transporting a pathogen under ambient conditions, by culturing the pathogen with an amoeba under conditions that favor the incorporation of the pathogen into a trophozoite, starving the amoeba until it encysts, then culturing under conditions that favor conversion of the amoeba back to a trophozoite. In one aspect, the conditions that favor incorporation of the pathogen into the cyst of the amoeba comprises contacting the pathogen with the amoeba in an iron rich environment. Virus and/or bacteria are pathogens that can be transported by the disclosed method. Amoeba that are useful in the disclosed methods include, without limitation | 03-24-2016 |
20160084743 | SOLUTION AND METHOD FOR ADHERING SUSPENSION COMPONENTS TO A SUBSTRATE - This disclosure is directed to a method and an attachment solution for adhering a cytological or histological sample, such as buffy coat, to a substrate, such as a microscope slide. The attachment solution includes an attachment base, an anti-coagulant, and a nonsteroidal anti-inflammatory drug. The attachment base may be an alcohol, an acid, an oxidizer, an organohalogen, a ketone, or any combination thereof. Once a sample is obtained, the sample may be re-suspended in the attachment solution or the attachment solution may be added to the sample. The sample may then be dispensed onto an analysis platform as one or more droplets and cured. | 03-24-2016 |
20160084750 | MICROFLUIDIC SYSTEMS AND METHODS FOR HYDRODYNAMIC MICROVORTICAL CELL ROTATION IN LIVE-CELL COMPUTED TOMOGRAPHY - Microfluidic devices for 3D hydrodynamic microvortical rotation of at least one live single cell or cell cluster, systems incorporating the devices, and methods of fabricating and using the devices and systems, are provided. A microfluidic chip rotates at least one live single cell or cell cluster in a microvortex about a stable rotation axis perpendicular to an optical axis within a chamber having a trapezoidal cross-sectional shape located below a flow channel. An optical trap may be used to position the cell or cells with the microvortex, and the cell or cells may be subject to live-cell or cell cluster computer tomography imaging. | 03-24-2016 |
20160090616 | METHOD AND APPARATUS FOR DISPERSION OF MICROBES IN A LIQUID SUSPENSION - An apparatus for dispersing microbes in a biological sample such as a liquid suspension sample and measuring turbidity of the liquid suspension is disclosed. The apparatus is configured for dispersing the microbes in a liquid suspension without destroying the integrity of the microbes and measure the turbidity of the sample suspension at the same time or in the same sample set up without having to move the microbe sample from one equipment to another. | 03-31-2016 |
20160090617 | CONCENTRATION DEVICE FOR MICROORGANISMS IN LARGE VOLUMES OF TURBID WATER AND METHOD THEREFOR - A device and method for concentrating microorganisms in large volumes of turbid water. When particulate builds up at the inlet filter header and pressure increases, filtrate that has collected within the filtrate reservoir serves as backflush fluid. The hollow fiber filter cartridge is backflushed as the pump reverses and filtrate flows from the filtrate reservoir, back through the hollow fiber filter cartridge, and out the inlet filter header, thereby dislodging the accumulated particulate. Elution solution is pumped though the device to remove microorganisms that may have adhered to the filter fibers and tubing. The retentate is then recovered by forward flushing the filter with eluting solution so that the retentate is sent to the off-line retentate sample container. There, the retentate sample is isolated and prevented from re-entering the hollow fiber filter cartridge. The inlet filter header therefore serves as an in-line pre-filter. | 03-31-2016 |
20160107156 | CONTROLLED TRANSFER BIOLOGICAL SAMPLE COLLECTION DEVICES AND METHODS OF USING SUCH DEVICES - A controlled transfer biological sample material collection device is disclosed which includes a body and a sample collection member for collecting the biological sample material, the body housing a sample storage medium for generally dry storage of the biological material, the collection member being moveable from an exposed position where collection of a biological sample is possible, to a transfer position which effects transfer of at least a portion of the collected sample to said medium. The body of the device slideably supports the sample collection member, and the body or collection member includes a ramp-like projection portion operable to force the collection member into the transfer position against the medium and to effect the transfer as the collection member slides within the body. | 04-21-2016 |
20160108454 | MAGNETIC SEPARATION OF RARE CELLS - A magnetic separation system configured to separate with high qualitative and quantitative yield magnetized cells from cell mixtures, comprising at least one electromagnet structured to generate a magnetic field flux about a plurality of separation zones and sufficient to attract a majority of the magnetized cells in the mixture, and a pump to drive the cell mixture at a controlled flow rate through a tube disposed within the zones thereby separating a majority of the magnetized cells from the mixture. The system is particularly useful to retrieve rare cells from a fluid mixture of cells having low abundance of the rare cells relative to the rest of the cells while sustaining viability of the cells. | 04-21-2016 |
20160115520 | RAPID MICROBIAL DETECTION - Devices and methods are provided to detect the presence of bacteria and small microorganisms, and to identify various microbial attributes rapidly. | 04-28-2016 |
20160121331 | SORTING PARTICLES IN A MICROFLUIDIC DEVICE - A microfluidic device includes a particle sorting region having a first, second and third microfluidic channels, a first array of islands separating the first microfluidic channel from the second microfluidic channel, and a second array of islands separating the first microfluidic channel from the third microfluidic channel, in which the island arrays and the microfluidic channels are arranged so that a first fluid is extracted from the first microfluidic channel into the second microfluidic channel and a second fluid is extracted from the third microfluidic channel into the first microfluidic channel, and so that particles are transferred from the first fluid sample into the second fluid sample within the first microfluidic channel. | 05-05-2016 |
20160122798 | SYSTEMS AND METHODS FOR ASEPTIC SAMPLING - A sampling assembly configured to be coupled to a sample source and facilitate aseptic sampling at one or more instances in time is provided. Further, the sampling assembly includes a first conduit having first and second ports, where the first port is configured to be coupled to the sample source. The sampling assembly also includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connector junctions. Also, each of the sub-ports is in fluidic communication with the first conduit. The sampling assembly also includes a plurality of sampling kits and one or more pumping devices. Further, each sampling kit is operatively coupled to a respective sub-port of a corresponding sub-conduit. Moreover, the one or more pumping devices are operatively and aseptically coupled to the second port of the first conduit. | 05-05-2016 |
20160123858 | CONCENTRATING PARTICLES IN A MICROFLUIDIC DEVICE - A microfluidic device includes: a first microfluidic channel; a second microfluidic channel extending along the first microfluidic channel; and a first array of islands separating the first microfluidic channel from the second microfluidic channel, in which each island is separated from an adjacent island in the array by an opening that fluidly couples the first microfluidic channel to the second microfluidic channel, in which the first microfluidic channel, the second microfluidic channel, and the islands are arranged so that a fluidic resistance of the first microfluidic channel increases relative to a fluidic resistance of the second microfluidic channel along a longitudinal direction of the first microfluidic channel such that, during use of the microfluidic device, a portion of a fluid sample flowing through the first microfluidic channel passes through one or more of the openings between adjacent islands into the second microfluidic channel. | 05-05-2016 |
20160130631 | MASS SPECTROMETRIC DIAGNOSIS OF SEPTICEMIA - The invention mainly relates to the mass spectrometric identification of pathogens in blood cultures from bloodstream infections (septicemia). The invention provides a method with which microbial pathogens can be separated in purified form from blood after a relatively brief cultivation in a blood culture flask, without any interfering human proteins or any residual fractions of blood particles such as erythrocytes and leukocytes, and can be directly identified by mass spectrometric measurement of their protein profiles. The method is based on the use of relatively strong tensides to destroy the blood particles by dissolving the weak cell membranes and most of the internal structures of the blood particles; in spite of the fact that tensides are regarded as strong ionization inhibitors in MALDI and other ionization processes required for mass spectrometric measurements. This method allows unknown pathogens to be obtained in their pure form by centrifuging or filtration and to be identified on the taxonomic level of species or subspecies. Problems with DNA from high levels of leukocytes can be resolved by special measures. After sufficient cultivation, the identification in a mass spectrometric laboratory takes only half an hour. | 05-12-2016 |
20160139005 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends. | 05-19-2016 |
20160139026 | METHOD FOR SORTING CELL PARTICLE IN SOLUTION - A method for sorting a cell particle in a solution includes steps of preparing an apparatus having a sample solution reservoir formed on a substrate, a main flow path formed in the substrate, a first branched flow path and a second branched flow path, and a downstream flow path; storing a sample solution; applying a constant gas pressure to the sample solution, illuminating the sample solution; determining calculating a delayed timing; and applying a pushing pressure. | 05-19-2016 |
20160153868 | EXTRACTION OF MATERIALS FROM REGIONS OF INTEREST IN A SAMPLE | 06-02-2016 |
20160168617 | CELLULAR PROBE DEVICE, SYSTEM AND ANALYSIS METHOD | 06-16-2016 |
20160178490 | CAPTURE SYSTEM OF CELLS AND METHODS | 06-23-2016 |
20160178491 | CAPTURE SYSTEM OF CELLS AND METHODS | 06-23-2016 |
20160184822 | MICROFLUIDIC DEVICE FOR PARTICLE ENUMERATION - This invention relates to a microfluidic device for conducting automatic particle enumeration. The microfluidic device comprises an inlet, a microchannel, an outlet, multiple branched channels and a sensing channel. The microchannel has a plurality of loops. Each of the branched channels interconnects at least two adjacent loops. The particles in the fluid migrate toward an inner channel wall of the microchannel when the particles pass through the sensing channel. The sensing channel includes a staircase-shaped slit pattern for optical particle enumeration of the particles passing through the sensing channel. | 06-30-2016 |
20160201108 | METHOD AND APPARATUS FOR PREPARING A CELLULAR CONTAINER COMPRISING MEANS FOR PRE-ANALYSIS OF A SAMPLE THAT HAS BEEN TAKEN | 07-14-2016 |
20160202150 | LASER MICRODISSECTION SYSTEM AND LASER MICRODISSECTION SYSTEM METHOD | 07-14-2016 |
20160202278 | AUTOMATIC METHOD AND AUTOMATED DEVICE FOR PROCESSING A PLURALITY OF CELL SUSPENSIONS | 07-14-2016 |
20160250629 | Kit, Method And Assembly For Preparing A Sample | 09-01-2016 |
20170232439 | SEPARATION OF LOW-ABUNDANCE CELLS FROM FLUID USING SURFACE ACOUSTIC WAVES | 08-17-2017 |
20170234851 | Methods and Apparatus for Segregation of Particles | 08-17-2017 |
20190144911 | SCREENING AND CULTURE METHOD | 05-16-2019 |
20190144915 | LARGE SURFACE AREA COLLECTION SPONGE FOR CULTURING SAMPLES | 05-16-2019 |
20220136954 | Method for Optimising the Concentration of Elements of Interest for Visual Measurement on a Biological Sample - The invention relates to a method for imaging a body fluid sample for visual measurements relating to leukocytes, which comprises: —obtaining a measured concentration (WIC) of leukocytes in the sample; —diluting ( | 05-05-2022 |