Entries |
Document | Title | Date |
20080199893 | Medical Biosensor By Means of Which Biological Liquids are Analyzed - Medical biosensor by means of which biological liquids are analyzed, having at least three layers; a functional layer to which a contact adhesive strip, adhesive on both sided, is applied, and a structural film applied to the contact adhesive strip. | 08-21-2008 |
20080199894 | DEVICE AND METHOD FOR AUTOMATIC DATA ACQUISITION AND/OR DETECTION - Methods and system for providing diabetes management including automatic time acquisition protocol and expiration date detection are provided. | 08-21-2008 |
20080206799 | CARBOHYDRATE RATIO TESTING USING FREQUENT BLOOD GLUCOSE INPUT - An apparatus comprising a user interface configured to generate an electrical signal to begin a carbohydrate ratio test when prompted by a user, an input configured to receive sampled blood glucose data of a patient that is obtained during a specified time duration (including a time duration after delivery of an initial carbohydrate insulin bolus), and a controller in electrical communication with the input and the user interface. The controller includes a carbohydrate ratio module configured to establish a blood glucose baseline from a measure of an initial blood glucose level of the patient, and determine a carbohydrate ratio according to a difference between a blood glucose level of the patient at the end of the specified time duration and the blood glucose baseline. Other systems and methods are disclosed. | 08-28-2008 |
20080213809 | STABLE NAD/NADH DERIVATIVES - The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits. | 09-04-2008 |
20080220460 | MODIFIED FLAVIN ADENINE DINUCLEOTIDE DEPENDENT GLUCOSE DEHYDROGENASE - Object: An object of the present invention is to provide a more practically advantageous enzyme usable as a reagent for measuring blood glucose than the known enzymes used as blood glucose sensors. | 09-11-2008 |
20080220461 | Methods for using a diagnostic test strip for collecting and detecting an analyte in a fluid sample - A test strip for use of the determination of an analyte in a fluid sample according to one embodiment of the present invention is disclosed. The test strip comprises a base having a top and a bottom, a collection chamber that extends between the top and the bottom of the base, a containing ring that is disposed on the bottom of the base and surrounds the collection chamber, and a capillary channel formed in top of the base that has an inlet fluidly coupled to the collection chamber, a test element disposed within the capillary channel. A lid is attached to the top of the base and covers the collection chamber, the test membrane, and at least a portion of the capillary channel. | 09-11-2008 |
20080227130 | Method for detecting exposure to ionizing radiation - A method for detecting exposure to ionizing radiation. An HbA1c test is performed on blood extracted from an animal at a first time, to establish a baseline glycosylated hemoglobin score, and a second HbA1c test is performed on blood extracted from the animal at a second time, to establish a test glycosylated hemoglobin score. The test and baseline scores are compared to determine any difference, and an inference is drawn as to whether the animal has or has not been exposed to ionizing radiation between the first and second times based, at least in part, on the amount of the difference. | 09-18-2008 |
20080268485 | Iconic Display of Markers for a Meter - This invention relates to an iconic display of pre-event or post-event iconic markers for a meter and a method for marking an analyte concentration with a pre-event or post-event iconic marker. The meter includes at least one segment on a display adapted to show a pre-event or post-event iconic marker. The user can interact with the meter via a button on the meter. The button allows the user to scroll from pre-event, post-event, and neither iconic marker, and it also allows the user to select one or neither of the iconic markers. A memory device located within the meter stores the analyte concentration with the corresponding pre-event, post-event, or neither iconic marker. | 10-30-2008 |
20080268486 | DUAL MEASUREMENT ANALYTE DETECTION SYSTEM - An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range. | 10-30-2008 |
20080280312 | Mutant Glucose Dehydrogenase - Substrate specificity for glucose of a glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 13 is improved by substituting another amino acid residue for the amino acid residue at position 472 and/or 475. | 11-13-2008 |
20080293082 | INSTRUMENT - A method and apparatus for performing a first measurement on a biological fluid or control, which first measurement varies with both the concentration of a first component and at least one of the presence and concentration of a second component. The method and apparatus perform a second measurement on the biological fluid or control, which second measurement varies primarily only with the at least one of the presence and concentration of the second component to develop an indication of the at least one of the presence and concentration of the second component. The first and second measurements may be made sequentially or simultaneously. The method and apparatus then remove an amount representative of the indicated presence or concentration of the second component from the concentration of the first component indicated by the first measurement. | 11-27-2008 |
20080305506 | FLUORESCENT DYES FOR USE IN GLUCOSE SENSING - A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection. | 12-11-2008 |
20090004682 | Method for Measuring Glucose Concentration in Blood Using Infrared Spectroscopy and Instrument Employing It - The objective of the present invention is to provide a method and instrument for measuring glucose concentration in blood using infrared spectroscopy. Glucose concentration in blood is measured based on an integrated value obtained by measuring an absorption spectrum that includes the wavelength range of 1020-1040 cm | 01-01-2009 |
20090011449 | NO CALIBRATION ANALYTE SENSORS AND METHODS - A meter and sensors, for use in combination, where no calibration code has to be entered by the user or is read by the meter. The meter is configured with a predetermined slope and y-intercept built into the meter. If the slope and y-intercept of the sensor are within a predetermined area or grid, or otherwise close to the slope and y-intercept of the meter, the batch of sensors is acceptable for use with that meter for providing accurate analyte concentration results. | 01-08-2009 |
20090035795 | METHOD AND COMPOSITION FOR FORMING A UNIFORM LAYER ON A SUBSTRATE - A method of reducing thickness non-uniformity in a microjet-deposited solids layer is disclosed which comprises depositing onto a substrate by microjet deposition a composition containing a liquid vehicle, at least one reagent; and a polyol which is present at a concentration that enhances thickness uniformity of a solids layer, containing the reagent(s), which is formed when the microjet-deposited composition is dried. | 02-05-2009 |
20090098586 | Assay for Determination of Free D-galactose and/or L-arabinose - The invention provides an assay kit for the measurement of free D-galactose and/or Larabinose in a sample, the kit comprising galactose mutarotase and (3-galactose dehydrogenase. The kit may further comprise a reagent capable of hydrolysing molecules containing D-galactose and/or L-arabinose, to yield the free mono- or disaccharide so that the kit finds use for determination of not just of free D-galactose and/or L-arabinosebut also those molecules as released (or synthesized) from other molecules, including lactose, D-galacose-1-phosphate, galactosyl-sucrose oligosaccharides (such as raffinose), galactan, galactomannan, arabinan and arabinogalactan. | 04-16-2009 |
20090098587 | METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM - A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider. | 04-16-2009 |
20090148874 | MUTANTS OF PYRROLOQUINOLINE QUINONE DEPENDENT SOLUBLE GLUCOSE DEHYDROGENASE - A mutant of PQQ-dependent soluble glucose dehydrogenase (s-GDH; EC 1.1.5.2) is provided with improved specificity for glucose as compared to maltose, having a substitution of threonine at position 348 by either glycine, alamine or serine, wherein said mutant additionally comprises, at least one mutation for improving the stability of the mutant and one or more mutation(s) for improving the affinity of the mutant to glucose, and/or one or more mutation(s) for further improving the specificity of the mutant for glucose as compared to maltose, and wherein position 348 correspond to the amino acid positions known from the | 06-11-2009 |
20090148875 | Control markers for auto-detection of control solution and method of use - A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt. | 06-11-2009 |
20090176262 | COENZYME-BINDING GLUCOSE DEHYDROGENASE - The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has an activity to maltose as low as 5% or less, and is inhibited by 1,10-phenanthroline. The invention also provides a method for producing the coenzyme-binding glucose dehydrogenase, and a method and a reagent for measuring employing the coenzyme-binding glucose dehydrogenase. According to the invention, the coenzyme-binding glucose dehydrogenase can be applied to an industrial field, and a use becomes possible also in a material production or analysis including a method for measuring or eliminating glucose in a sample using the coenzyme-binding glucose dehydrogenase as well as a method for producing an organic compound. It became also possible to provide a glucose sensor capable of accurately measuring a blood sugar level. Therefore, it became possible to provide an enzyme having a high utility, such as an ability of being used for modifying a material in the fields of pharmaceuticals, clinical studies and food products. | 07-09-2009 |
20090208989 | Fluorescence Spectropscopy In Absorbing Media - The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement. | 08-20-2009 |
20090246808 | BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY - A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5. | 10-01-2009 |
20090298104 | REFERENCE ELECTRODES HAVING AN EXTENDED LIFETIME FOR USE IN LONG TERM AMPEROMETRIC SENSORS - The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions. | 12-03-2009 |
20090305316 | Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase - The present invention relates to a mutant protein of PQQ-dependent s-GDH characterized in that in at least one of the positions 122 and 124 the amino acid lysine is present, wherein these positions correspond to the amino acid positions known from the | 12-10-2009 |
20090305317 | USER INTERFACE FOR TESTING DEVICE - A testing system for testing an analyte in a fluid sample includes a user interface including a display for displaying information relating to measurements of health data and an input device for receiving information from a user relating to the health data. The testing system further includes an automarking feature adapted to identify a testing result of a control solution, the testing of the control solution being distinguishable from the testing of the fluid sample. The testing result of the control solution is not included in the information relating to the measurements of health data that is displayed to a user via the user interface. | 12-10-2009 |
20090317847 | METHOD FOR DETERMINING AN ANALTYE IN A BODILY FLUID - A method for determining (e.g., detecting and/or measuring the concentration of) an analyte in a bodily fluid sample includes obtaining a bodily fluid sample, applying the bodily fluid sample to an analyte test strip, transferring the applied bodily fluid sample to a sample-receiving chamber of the analyte test strip, and determining an analyte in the bodily fluid sample. The analyte test strip employed in the method includes a first port in fluidic communication with the sample-receiving chamber and proximate a platform portion of the analyte test strip. Moreover, the platform portion is configured to receive a first (relatively large) bodily fluid sample of at least 5 micro-liters and transfer at least a portion of the first bodily fluid sample to the sample-receiving chamber via the first port. The analyte test strip also includes a second port in fluidic communication with the sample-receiving chamber and an outer edge of the analyte test strip, the second port configured to receive a second (relatively small) bodily fluid sample of lesser volume than the first bodily fluid sample and for transferring at least a portion of the second bodily fluid sample to sample-receiving chamber. In addition, the applying step involves applying the bodily fluid sample to one of the second port and the platform portion of the analyte test strip depending on the volume of the bodily fluid sample. | 12-24-2009 |
20090317848 | MODIFIED FLAVIN ADENINE DINUCLEOTIDE DEPENDENT GLUCOSE DEHYDROGENASE - The invention provides a modified flavin adenine dinucleotide dependent glucose dehydrogenase (FADGDH), as well as a glucose sensor comprising the modified FADGDH and a method for measuring glucose comprising using the glucose sensor to measure glucose of a sample | 12-24-2009 |
20090325205 | METHOD FOR MEASURING ANALYSIS OBJECT, BIOSENSOR AND MEASURING DEVICE - A biosensor | 12-31-2009 |
20100021947 | Detection meter and mode of operation - A method for performing an assay to determine the presence or concentration of an analyte contained in a sample of body fluid by using a device comprising at least one analyte quantification member and a sensor associated therewith, the method includes: applying a first sample to the analyte quantification member; and detecting the presence or absence of an adequate sample volume; wherein upon detection of the absence of an adequate sample volume, initiating a finite timed period, and signaling the user to introduce a second sample of body fluid to the analyte quantification member. Associated arrangements and devices are also disclosed. | 01-28-2010 |
20100021948 | Medical diagnostic devices and methods - A medical diagnostic device includes a wirelessly transmitted time data receiver and processor. Associated devices, methods and functionality are also described. | 01-28-2010 |
20100028920 | Hydrogen Peroxide Droplet-Based Assays - The present invention relates to providing improved hydrogen peroxide assays, as well as droplet actuators for conducting such assays. The droplet actuators of the invention may be used to conduct droplet-based hydrogen peroxide assays. They may also be associated with detectors for analyzing the results of the hydrogen peroxide assays of the invention. They may be provided as components of systems which control droplet operations and/or detection for conducting the hydrogen peroxide assays. Measurement by the detector may be used to quantify the presence of an analyte in a sample. | 02-04-2010 |
20100041082 | METHODS FOR DETERMINING THE METABOLISM OF SUGARS AND FATS IN AN INDIVIDUAL - Provided herein are methods for determining the metabolism of one or more sugars and/or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis and glycolysis, which are believed to be early markers for predicting elevated risk of diabetes and cardiovascular disease. Other applications include methods for screening drugs that effect sugar and/or fatty acid metabolism. The methods are useful for at least partially characterizing drugs for desirable or undesirable (toxic) characteristics. Drugs that are at least partially characterized using the methods of the invention can then be further developed in pre-clinical testing and clinical trials. Such drugs may be found to be useful in treating obesity, diabetes, cardiovascular disease, and other disorders of metabolism. | 02-18-2010 |
20100041083 | METER ADAPTED TO SIMULTANEOUSLY DISPLAY THE NUMBER OF HIGH, LOW AND TOTAL TEST RESULTS - A meter adapted for evaluating, saving and simultaneously displaying the number of analyte concentration readings that are greater than a first predetermined analyte concentration level, the number of analyte concentration readings that are less than a second predetermined analyte concentration level and the total number of analyte concentration readings over a predetermined time interval. | 02-18-2010 |
20100041084 | ANALYTE TESTING METHOD AND SYSTEM - Described and illustrated herein is an exemplary method of operating an analyte measurement device having a display, user interface, processor, memory, and user interface buttons. Such method can be achieved by measuring an analyte with the analyte measurement device, displaying a value representative of the analyte, querying a user to select a predetermined flag to associate the predetermined flag with the value, and pressing only one of the user interface buttons once to store the predetermined flag with the value in the memory of the analyte measurement device. In one embodiment, the testing device is a glucose meter and the analyte being tested is glucose. | 02-18-2010 |
20100062464 | OXIDATIVE CHROMOGENIC COMPOUND OR SALT THEREOF AND PRODUCTION METHOD THEREOF, AND REAGENT COMPOSITION AND TEST INSTRUMENT USING THE SAME - It is an object of the present invention to provide a means for measuring a concentration of various components rapidly with high accuracy and high sensitivity. The present invention is to provide an oxidative chromogenic compound or salt thereof represented by the following chemical formula (1): | 03-11-2010 |
20100068740 | MICROFLUIDIC DEVICE WITH A CYLINDRICAL MICROCHANNEL AND A METHOD FOR FABRICATING SAME - A method of manufacturing a microfluidic device having at least one cylindrical microchannel includes providing a substrate, casting an uncured polymer matrix solution onto the substrate, embedding an elongated rod in the uncured polymer matrix solution, curing the polymer matrix solution to form a solidified body, and extracting the elongated rod to form the cylindrical microchannel in the solidified body. In another embodiment, the method includes forming an optical feature on a surface of the microfluidic device. A microfluidic device is also provided, the device including a polymer body, and at least one cylindrical microchannel in the polymer body, the cylindrical microchannel having a diameter between approximately 40 ?m and 250 ?m, inclusive. An additional microfluidic device is provided that functions as an optofluidic spectrometer. The optofluidic spectrometer includes a polymer body, a diffraction grating integrated within the polymer body, and a cylindrical microchannel behind the diffraction grating on the polymer body. | 03-18-2010 |
20100075352 | Method of assaying bolld component by using whole blood and measurement kit - [Problem] In quickly assaying a blood component interfered by glucose and/or its derivative on the bedside or in a clinic or in assaying the same by a patient in his/her own home, there has been required an assay method wherein the whole blood can be used as a sample as such without resorting to a centrifuge or the like. | 03-25-2010 |
20100075353 | Method And Glucose Monitoring System For Monitoring Individual Metabolic Response - A system and a method for monitoring individual metabolic responses and generating nutritional feedback based on the monitored responses in a qualified subject are disclosed. Measurements of glucose level in the subject are consecutively performed by a measuring device to generate corresponding first data. Subsequently, data is transmitted to an analysis device, where second data representing glycemic responses is generated from a time-series of glucose level measurements represented by the first data. In a next step, the second data is compared with a predetermined individual glycemic response budget for the subject which represents a total amount of individual glycemic responses allowable for a certain time period. Finally, feedback corresponding to the result of the comparison is provided by an output device. | 03-25-2010 |
20100081152 | Small Volume In Vitro Analyte Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent. | 04-01-2010 |
20100086954 | Small Volume In Vitro Analyte Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent. | 04-08-2010 |
20100112612 | METHOD FOR DETERMINING AN ANALYTE USING AN ANALYTICAL TEST STRIP WITH A MINIMAL FILL-ERROR VIEWING WINDOW - A method for determining an analyte (such a glucose) in a bodily fluid sample includes introducing a bodily fluid sample (e.g., a whole blood sample) into a sample-receiving chamber of an analytical test strip. The method also includes verifying that the bodily fluid sample has filled at least a working portion of the sample-receiving chamber by user visual observation of the working portion through a first portion of a top layer of the analytical test strip, while an opaque second portion of the top layer precludes user visual observation of a non-working portion of the sample-receiving chamber. Thereafter, in the method, the concentration of analyte in the bodily fluid sample is determined only if during the verifying step the user has verified that the bodily fluid sample has filled the working portion. | 05-06-2010 |
20100112613 | Biosensor Membranes Composed of Polymers Containing Heterocyclic Nitrogens - Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described. | 05-06-2010 |
20100112614 | Coupled Antenna Impedance Spectroscopy - It has been found advantageous to deploy coiled antennas as transmitters and receivers for acquiring the dielectric spectrum of materials. This method of impendence spectroscopy has been used to determine the concentration of glucose and other small polar molecules in vitro, as well as in vivo by placement on the antennas so that transmission is through the tissue, as for example on opposite sides of an organ or body part. The optimum selection of antenna coils permits deeper penetration into tissue for glucose detection, improves the SNR as well as expands the spectral range for greater accuracy and precision, to enable continuous non-invasive monitoring for either improved patient or automated management of diabetes. | 05-06-2010 |
20100143955 | REAGENT FOR BLOOD ANALYSIS AND METHOD OF USING THE SAME - A reagent for blood analysis includes: (1) a compound having the general formula I; and (2) at least one surfactant selected from cationic surfactants and nonionic surfactants. In another aspect a method for differentiating and counting blood cells is provided, the method includes the following steps: (a) mixing a blood sample with the reagent for blood analysis according to the present disclosure to form a cell suspension; (b) detecting scattered light signals and fluorescence signals of cells in the blood sample; and (c) differentiating and counting the cells in the blood sample based upon the scattered light signals and fluorescence signals. The reagent for blood analysis may be effective for identifying and counting erythroblasts and/or basophils in a blood sample to be detected, and meanwhile counting leukocytes therein. | 06-10-2010 |
20100216175 | Condensate Glucose Analyzer - Systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments, electrochemical- or coulometnc-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose. Based on the detected glucose m EBC, the subject invention provides systems and methods for non-invasive, accurate assessment of blood glucose levels. | 08-26-2010 |
20100227348 | METHOD AND DEVICE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE USING FLUORESCENCE MEASUREMENT - A method is presented for determining the concentration of an analyte in a liquid sample using a reagent system. The reaction of the sample with the reagent system results in a change of the quantity of a fluorophore, the quantity of the fluorophore correlating with the concentration of the analyte, a characteristic measurement variable for the quantity of the fluorophore being measured, and the concentration of the analyte being determined using an evaluation algorithm on the basis of the measurement variable. The reagent system is integrated in an analysis system and the fluorescence lifetime of the fluorophore is used in the ascertainment of the concentration of the analyte. | 09-09-2010 |
20100240079 | GLUCOSE TOLERACE TEST DEVICE - A glucose tolerance test device comprising: a test zone having a means to receive at least first and second blood test samples spaced apart by a predetermined time interval; a timer to measure such a time interval, and for example to measure elapsed time after collection of a said first sample; an indicator to indicate at least that a second test is due, operatively Jinked to the timer so as to make such indication after lapse of a predetermined time interval; a data collector to collect data from the lest zone in relation to each test sample; a data register to store data in relation to each test sample, in data communication with said data collector. A method of use is also described. | 09-23-2010 |
20100248279 | SUBSTRATE PROBE, ENZYME-ACTIVITY DETECTION METHOD BY A MULTI-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE METHOD AND ENZYME-ACTIVITY IMAGING METHOD - Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method. | 09-30-2010 |
20100255517 | Apparatus for Preventing Electrical Shock in Devices - A device for preventing electrical shock from a device with electrical interfaces. A shutter or other barrier associated with the device that physically prevents access or contact to one of the electrical interfaces while another electrical interface is in use. | 10-07-2010 |
20100279326 | METHOD FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID - A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence. The second lens is adapted to receive light from the first lens and adapted to output a substantially collimated beam of light. The detector is adapted to measure the light output by the second lens. | 11-04-2010 |
20100291604 | PREDICTIVE TREATMENT OF DYSGLYCEMIC EXCURSIONS ASSOCIATED WITH DIABETES MELLITUS - A predictive technique for treating diabetes mellitus is described whereby a patient's blood glucose levels are monitored “continuously” over an extended period of time and a life-event diary is maintained records all significant life-events (e.g., food intake, medication, exercise, mood/emotions, etc.). This information is analyzed to derive a mathematical model that closely matches the patient's glucose level variations for the period of monitoring. Specific daily time periods of dysglycemic vulnerability are determined by calculating when the mathematical model predicts that crossings of predetermined hyperglycemic and hypoglycemic threshold levels will occur. These predicted periods of vulnerability are then used to devise a therapeutic plan that administers treatment in anticipation of predicted dysglycemic excursions, thereby limiting the extent of those excursions or eliminating them altogether. | 11-18-2010 |
20100311092 | METABOLIC FUEL SWITCHING BIOMARKER - Disclosed is a method for measuring and determining whole body insulin release functionality, in which a plurality of physiologically acceptable differentially labeled carbohydrates is administered. A first administered carbohydrate label metabolizes faster than at least one of the other administered carbohydrate labels and recycling rates of at least two of the plurality of labeled carbohydrates are monitored. First and subsequent insulin release phases are detected. The first insulin release phase is detected by comparison of a recycling rate of the first administered carbohydrate with a recycling rate of the subsequent administered carbohydrate. | 12-09-2010 |
20100323378 | MODIFIED GLUCOSE DEHYDROGENASE GENE - [Object] To provide an FAD-conjugated glucose dehydrogenase having a higher specificity for glucose. | 12-23-2010 |
20100330598 | METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR PROVIDING BOTH AN ESTIMATED TRUE MEAN BLOOD GLUCOSE VALUE AND ESTIMATED GLYCATED HEMOGLOBIN (HbA1C) VALUE FROM STRUCTURED SPOT MEASUREMENTS OF BLOOD GLUCOSE - A method and system for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements are disclosed. The bG measurements and associated context of the bG measurement are collected at daily times specified by a structured sampling schema, and the collected bG measurements are weighted based on the associated context. The estimated true mean bG value and the estimate HbA1C value are then determined from the weighted measurements of the collected bG measurements. A computer program for implementing the method for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements is also disclosed. | 12-30-2010 |
20110020851 | NOVEL GLUCOSE DEHYDROGENASE - The invention provides a glucose dehydrogenase that is an extremely stable enzyme having a thermostability of 80° C. or more, and that does not substantially act upon saccharides other than glucose (e.g., having a reactivity of less than 3% with respect to maltose, galactose, and xylose). The invention also provides a method for producing such an enzyme, and a composition for quantifying glucose using such an enzyme. | 01-27-2011 |
20110020852 | METHOD OF ANALYZING BIOLOGICAL COMPONENT, BIOLOGICAL COMPONENT ANALYZER AND EXTRACTION CARTRIDGE - This method of analyzing a biological component includes steps of arranging an extraction medium holding part configured to be capable of holding a prescribed quantity of extraction medium for holding an extract extracted from a subject on the skin of the subject, transferring the extraction medium stored in a liquid storing part storing substantially the same quantity of the extraction medium as the prescribed quantity to the extraction medium holding part, transferring at least part of the extraction medium holding the extracted extract to a reaction part, and analyzing a result of detecting the extract. | 01-27-2011 |
20110033880 | FAD-CONJUGATED GLUCOSE DEHYDROGENASE GENE - An object of the present invention is to provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties that it has excellent reactivity to glucose, excellent thermal stability, and excellent substrate-recognition performance and also has a low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; and a method for the determination of glucose, a reagent composition for use in the determination of glucose, a biosensor for use in the determination of glucose and others, each characterized by using the enzyme obtained. The invention relates to a polynucleotide encoding an FAD-conjugated glucose dehydrogenase, comprising a polypeptide containing an amino acid sequence: X1-X2-X3-X4-X5-X6 (wherein X1 and X2 independently represent an aliphatic amino acid residue; X3 and X6 independently represent a branched amino acid residue; and X4 and X5 independently represent a heterocyclic amino acid residue or an aromatic amino acid residue); and others. | 02-10-2011 |
20110039286 | Temperature-Adjusted Analyte Determination For Biosensor System - A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature. | 02-17-2011 |
20110045513 | PROTEIN ELECTRON MEDIATOR - The problem to be resolved is to provide an electron mediator and a fusion body with high affinity with an enzyme, a measuring method using extracellular secretion type cytochrome and an enzyme, an electrode, and a sensor. | 02-24-2011 |
20110053194 | TRANSFORMANT TRANSFECTED WITH FLAVIN ADENINE DINUCLEOTIDE-BINDING GLUCOSE DEHYDROGENASE GENE AND METHOD FOR PRODUCING FLAVIN ADENINE DINUCLEOTIDE-BINDING GLUCOSE DEHYDROGENASE USING THE SAME - It is intended to highly efficiently produce a large amount of novel FAD-GDH capable of more accurately measuring a glucose level. Provided is a transformant in which a DNA encoding a flavin adenine dinucleotide-binding glucose dehydrogenase selected from the group consisting of (a) a DNA encoding the amino acid sequence of SEQ ID NO: 20; (b) a DNA consisting of the base sequence of SEQ ID NO: 19; (c) a DNA having a base sequence homologous to the base sequence of SEQ ID NO: 19 and encoding a protein having a flavin adenine dinucleotide-binding glucose dehydrogenase activity; (d) a DNA encoding the amino acid sequence of SEQ ID NO: 34; (e) a DNA consisting of the base sequence of SEQ ID NO: 33; and (f) a DNA having a base sequence homologous to the base sequence of SEQ ID NO: 33 and encoding a protein having a flavin adenine dinucleotide-binding glucose dehydrogenase activity has been introduced. Further, a method for producing a flavin adenine dinucleotide-binding glucose dehydrogenase using the transformant is provided. | 03-03-2011 |
20110076707 | MUTANT GLUCOSE DEHYDROGENASE - Substrate specificity for glucose of a glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 13 is improved by substituting another amino acid residue for the amino acid residue at position 472 and/or 475. | 03-31-2011 |
20110091919 | pH-INSENSITIVE GLUCOSE INDICATOR PROTEIN - The present invention encompasses a glucose indicator protein, a biosensor comprising one or more glucose indicator proteins, and methods of use thereof. | 04-21-2011 |
20110097755 | Apparatus and Method for Optically Sensing Analyte Concentration in an Erythrocyte-Containing Fluid - A device for determination of analytes has optical material with a deposit on a surface thereof. The deposit includes an analyte-reactive reagent and a particulate material for enhancing reflectance of a light beam emitted through the optical material into the analyte-reactive reagent. The enhanced reflectance provides a return of light through the optical material at a level which is not only analytically useful, but involves sufficient returned light intensity so as to enable markedly improved sensitivity and accuracy in analytical determinations. A suitable particulate material is one of hollow spherical particles. Moreover, the particulate material may be selected for a property such as a neutralizing charge that suppresses the membrane-disruptive effects of certain types of optical materials and hemolytic reagents on blood cells such as erythrocytes. | 04-28-2011 |
20110136158 | PROTEIN ELECTRON MEDIATOR - The problem to be resolved is to provide an electron mediator and a fusion body with high affinity with an enzyme, a measuring method using extracellular secretion type cytochrome and an enzyme, an electrode, and a sensor. | 06-09-2011 |
20110189708 | METHOD FOR EVALUATING SPECIFIC INCORPORATION OF D-GLUCOSE INTO CELLS - An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities. | 08-04-2011 |
20110229916 | NANOFIBERS WITH HIGH ENZYME LOADING FOR HIGHLY SENSITIVE BIOSENSORS - The invention provides high enzyme loading nanofibers and processes utilized in their fabrication, the nanofibers suitable for use as a new class of highly sensitive and stable biosensors capable of monitoring glucose at low levels. The biosensors, comprising nanofiber enzyme materials fabricated from organic solvent-based polymer-enzyme systems, can be used effectively in non-invasive transdermal biosensing applications. | 09-22-2011 |
20110262942 | OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE IN CONTROL SOLUTIONS FOR BIOSENSORS - Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample. | 10-27-2011 |
20110300565 | ANALYSIS METHOD, ANALYSIS DEVICE, PROGRAM USED TO IMPLEMENT SAID ANALYSIS METHOD, AND STORAGE MEDIUM AND RETRIEVAL DEVICE FOR THIS PROGRAM - An analysis apparatus includes a first analysis unit which collects samples by utilizing a first nozzle to analyze the sample, a second analysis unit which collects samples by utilizing a second nozzle to analyze the sample, and a transport apparatus which transports a plurality of sample vessels along a predetermined transport route. When a predetermined waiting state is provided such that the transport of the plurality of sample vessels is interrupted or stopped, then the sample collecting position is changed for at least one of the first and second nozzles, and the samples are collected from the plurality of sample vessels by means of the nozzle having the changed position. Accordingly, it is possible to enhance the efficiency of the analysis process performed by the analysis apparatus, while suppressing the transport apparatus from being large-sized and suppressing the structure from being complicated. | 12-08-2011 |
20110312003 | DETERMINING PERFORMANCE CHARACTERISTICS OF A FERMENTER BATCH OF A BIOFUEL PRODUCTION PLANT - A method for determining performance characteristics of a fermenter batch in a biofuel production plant based on stoichiometry of fermentation reactions, comprising determining a cell mass of a sample of the fermenter batch; a glucose equivalent total (GET) based at least on the cell mass of the sample of the fermenter batch, and a starch to glucose conversion factor (SGCF) based at least on the GET; a total amount of glucose based at least on the SGCF, a volume of ethanol based at least on the total amount of glucose and the GET; at least one of a fermenter yield based at least on the volume of ethanol, and a fermenter efficiency based on the fermenter yield or the volume of ethanol; and generating an output based on the fermenter yield and/or the fermenter efficiency. | 12-22-2011 |
20110312004 | TEST STRIP WITH MAGNETO-ELASTIC-RESONANCE SENSOR - A test meter system for testing a characteristic of a fluid, the test meter system including a test meter having a housing with an opening adapted to accept a test strip, an interrogation coil within the housing, a pick-up coil within the housing, and a test strip including at least one magneto-electronic-resonance sensor. When the test strip is within the opening, the interrogation coil may utilize magneto-electronic-resonance technology to interrogate the magneto-electronic-resonance sensor and the pick-up coil may be used to sense a resultant oscillation frequency of the magneto-electronic-resonance sensor, the resultant oscillation frequency associated with the characteristic. The test strip may include a plurality of sensors. The sensors may be coated with a coating sensitive to a characteristic of the fluid, where the interrogation reveals information about the fluid characteristic. | 12-22-2011 |
20110318766 | Arginine vasopressin pro-hormone as predictive biomarker for diabetes - Subject of the present invention are assays and in vitro methods for the prediction of the risk of a subject for contracting metabolic syndrome and/or diabetes mellitus and for diagnosing metabolic syndrome, comprising determining the level of arginine vasopressin pro-hormone or fragments thereof in a sample of a subject. | 12-29-2011 |
20110318767 | Method for Measuring Plasma Glucose - A measurement of plasma glucose is carried out through the following steps, a sample preparation step (S | 12-29-2011 |
20120003675 | Method for Preparing Small Volume Reaction Containers - Engineered reaction containers that can be physically and chemically defined to control the flux of molecules of different sizes and charge are disclosed. Methods for constructing small volume reaction containers through a combination of etching and deposition are also disclosed. The methods allow for the fabrication of multiple devices that possess features on multiple length scales, specifically small volume containers with controlled porosity on the nanoscale. | 01-05-2012 |
20120009612 | METHOD TO DETECT AND MONITOR COMPARTMENT SYNDROME - Disclosed is a method of detecting and/or monitoring ischemia in a muscle tissue or compartment. The method includes the steps of measuring in real time or near-real time interstitial glucose concentration, or rate of change of interstitial glucose concentration over time, or both, in the muscle tissue or compartment. A reduced glucose concentration or a negative rate of change of glucose concentration in the tissue or compartment as compared to a control glucose concentration or rate of change indicates ischemia in the muscle or compartment. | 01-12-2012 |
20120015388 | Diluent for Preparing Analytical Sample - The ionic strength of a diluent for preparing an analytical sample is set to be 0.06 to 0.16. The analytical sample prepared by using the diluent having the ionic strength within this range can be subjected to both for analyzing a first object in a test sample by electrode method and for analyzing a second object in the test sample by liquid chromatography method, and high-precision measurement can be attained. The analytical sample is especially useful for preparing a sample for measurement used both for measuring glucose concentration in a blood sample by enzyme electrode method and for measuring glycohemoglobin concentration in the blood sample by liquid chromatography method. | 01-19-2012 |
20120028283 | Analyte Sensors Having Temperature Independent Membranes - Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane structure with an analyte permeability that is substantially temperature independent. The devices also include a sensing layer disposed on a working electrode of in vivo analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 02-02-2012 |
20120034636 | CHEMICAL SENSING DEVICE - This invention relates to a chemical sensing device for detecting an analyte. The device comprises a light source, at least one luminescent reagent which is capable of luminescing when irradiated by the light source wherein the luminescence of the luminescent reagent is modifiable by the analyte thereby changing the generation of heat, which change in heat generation is proportional to the concentration of the analyte, a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing the change in heat to an electrical signal, and a detector which is capable of converting the electrical signal into an indication of the concentration of the analyte. The invention also relates to a method for detecting an analyte. | 02-09-2012 |
20120040386 | FINE-GRAINED FILLER SUBSTANCES FOR PHOTOMETRIC REACTION FILMS - There is proposed a diagnostic test element for detecting an analyte in a sample of a body fluid, more particularly in whole blood. The diagnostic test element comprises at least one test field having at least one detection reagent, wherein the detection reagent is set up to pass through at least one detectable change in the presence of the analyte, more particularly an optical change. The test field has at least one detection layer which comprises the detection reagent and which comprises particles. At least 90% of all particles of the detection layer have an actual particle size of less than 10 micrometers. | 02-16-2012 |
20120077213 | CELL CULTURE IMPROVEMENTS - The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture. | 03-29-2012 |
20120094319 | METHOD OF DISPENSING BIOSENSORS - A storage cartridge for dispensing biosensors used in the determination of an analyte in body fluid comprises a hollow body for housing a stack of biosensors having an open top, a flexible conveying member disposed over the open top of the body, the flexible conveying member having an aperture formed therein for receiving a biosensor from the stack of biosensors, a plate adapted to press the sliding conveying member against the open top to form a substantially moisture-impervious seal around the open top of the body and to permit the conveying member to slide between the plate and the open top, and a biasing mechanism the stack of biosensors towards the open top. | 04-19-2012 |
20120122130 | Coenzyme-Linked Glucose Dehydrogenase and Polynucleotide Encoding the Same - The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to FAD to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor. | 05-17-2012 |
20120142037 | GLUCOSE DEHYDROGENASE - A modified pyrroloquinoline quinone glucose dehydrogenase that exhibits a high selectivity for glucose is provided. A modified pyrroloquinoline quinone glucose dehydrogenase is disclosed in which the amino acid residue G at Position 99 of a pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 1, or the amino acid residue G at Position 100 of the pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 3, is substituted by the amino acid sequence TGZN (where Z is SX, S, or N and X is any amino acid residue). The modified PQQGDH of the present invention may additionally comprise one or more mutations selected from the group consisting of Q192G, Q192A, or Q192S; L193X; E277X; A318X; Y367A, Y367F, or Y367W; G451C; and N452X (where X is any amino acid residue). | 06-07-2012 |
20120149048 | METHOD OF DIFFERENTIATING BETWEEN BLOOD AND CONTROL SOLUTIONS CONTAINING A COMMON ANALYTE - Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples. | 06-14-2012 |
20120171706 | GLUCOSE MEASUREMENT USING A CURRENT SOURCE - A blood glucose meter comprises a blood sample test strip, a constant current source, a precision timer, a digital processor and memory, and an analog measurement circuit, e.g., voltage comparator, analog-to-digital converter (ADC), etc., that eliminates the complex analog front end and other related circuits of present technology glucose meters. When a blood sample is applied to the blood sample test strip a charge, Q, develops from the reaction between an enzyme in the test strip and the blood sample. The constant current source injects a constant current value, I, into the charge, Q, on the blood sample test strip over a precisely measured time determined by when the excess charge, Q, has been removed from the test strip. The amount of charge, Q, is determined by Q=I*T, the charge, Q, is then converted into a blood glucose level for display. | 07-05-2012 |
20120171707 | ASSAY FOR INHIBITORS OF SUMO AND SUMO-TARGETED UBIQUITIN LIGASE PATHWAY - The present invention provides a method for determining a putative agent that inhibits the SUMO or the SUMO-targeted ubiquitin ligase pathway comprising the steps of contacting mutant MOT1 cells with the putative agent under conditions (1) permitting mutant MOT1 cell growth in the presence of a SUMO or SUMO-targeted ubiquitin ligase pathway inhibitor and (2) not permitting mutant MOT1 cell growth in the absence of a SUMO or SUMO-targeted ubiquitin ligase pathway inhibitor, and measuring cell growth. | 07-05-2012 |
20120171708 | MODIFIED FLAVIN ADENINE DINUCLEOTIDE-DEPENDENT GLUCOSE DEHYDROGENASE - Provided is an enzyme that is further advantageous in terms of practical aspects when compared to publicly known enzymes for blood sugar sensors, and that can be used in a blood sugar level measuring reagent. | 07-05-2012 |
20120178115 | Mutants of Pyrroloquinoline Quinine-Dependent Soluble Glucose Dehydrogenase - The present invention relates to novel mutants of PQQ s-GDH containing an amino acid substitution in position 428 of the protein sequence of the wild type PQQ s-GDH of | 07-12-2012 |
20120244565 | MUTANT ENZYME AND APPLICATION THEREOF - An object is to provide a novel enzyme that exhibits glucose dehydrogenase activity. Furthermore, another object is to provide a novel method pertaining to enzyme modification. Provided is a mutated enzyme containing an amino acid sequence wherein one or at least two amino acids selected from the group consisting of (1) to (13) are substituted with another amino acid in the amino acid sequence of a microorganism-derived glucose oxidase: (1) the amino acid corresponding to the amino acid at position 115 of the amino acid sequence of SEQ ID NO: 1; (2) the amino acid corresponding to the amino acid at position 131 of the amino acid sequence of SEQ ID NO: 1; (3) the amino acid corresponding to the amino acid at position 132 of the amino acid sequence of SEQ ID NO: 1; (4) the amino acid corresponding to the amino acid at position 193 of the amino acid sequence of SEQ ID NO: 1; (5) the amino acid corresponding to the amino acid at position 353 of the amino acid sequence of SEQ ID NO: 1; (6) the amino acid corresponding to the amino acid at position 436 of the amino acid sequence of SEQ ID NO: 1; (7) the amino acid corresponding to the amino acid at position 446 of the amino acid sequence of SEQ ID NO: 1; (8) the amino acid corresponding to the amino acid at position 472 of the amino acid sequence of SEQ ID NO: 1; (9) the amino acid corresponding to the amino acid at position 511 of the amino acid sequence of SEQ ID NO: 1; (10) the amino acid corresponding to the amino acid at position 535 of the amino acid sequence of SEQ ID NO: 1; (11) the amino acid corresponding to the amino acid at position 537 of the amino acid sequence of SEQ ID NO: 1; (12) the amino acid corresponding to the amino acid at position 582 of the amino acid sequence of SEQ ID NO: 1; and (13) the amino acid corresponding to the amino acid at position 583 of the amino acid sequence of SEQ ID NO: 1. | 09-27-2012 |
20120252045 | METHOD OF ASSESSING ISLET FUNCTION - A method for assessing islet function comprising determining an oxygen consumption rate (OCR) of the islets; determining an islet index (II) of the islets; and determining an OCR/II ratio, wherein a high OCR/II ratio correlates with increased islet function. The methods may be performed on islets in vitro. In some embodiments, the methods may be performed on islets to be used for transplantation after they are harvested from a donor pancreas and prior to transplanting the islets into a recipient. | 10-04-2012 |
20120252046 | TRANSDERMAL SYSTEMS, DEVICES, AND METHODS FOR BIOLOGICAL ANALYSIS - A transdermal test sensor includes a test chamber including a liquid, a reagent system in contact with the liquid, a housing containing the liquid, and a semipermeable membrane. The housing includes an opening, the semipermeable membrane is connected to the housing and covers the opening, and the housing and the semipermeable membrane enclose the liquid and the reagent system. The transdermal test sensor also includes an analyzer in communication with the liquid. When porated tissue is contacted with the semipermeable membrane and sufficient time is allowed for a fluid sample to traverse the porated tissue and for an analyte in the fluid sample to enter the liquid in the transdermal sensor through the semipermeable membrane, a change in at least one optical property or at least one electrical property of the liquid is detected. The change detected is then correlated with the analyte concentration in the fluid sample. | 10-04-2012 |
20120270248 | DETECTION OF BACTERIA IN BIOLOGICAL FLUIDS - A method for detecting bacteria in biological fluids is provided, the method comprising placing a biological fluid possibly containing bacteria in a container, the container including a detergent for reducing the respiration of blood cells, and a bacterial growth promoter, and measuring and/or detecting the level of glucose in the biological fluid in the container, over a period of time. A system for carrying out the method is also provided. | 10-25-2012 |
20120270249 | MEDIUM FOR THE SPECIFIC DETECTION OF RESISTANT MICROORGANISMS - A method for distinguishing among a first group of microorganisms, belonging to a first taxon of bacteria that is vancomycin resistant; a second group of microorganisms, belonging to a second taxon of vancomycin resistant bacteria that is different than said first taxon; and a third group of microorganisms that is not resistant or has a natural resistance to vancomycin. | 10-25-2012 |
20120276565 | STABILIZATION OF ENZYMES WITH STABLE COENZYMES - Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization. | 11-01-2012 |
20120276566 | MEDIUM FOR THE SPECIFIC DETECTION OF RESISTANT MICROORGANISMS - A method for distinguishing among a first group of microorganisms, belonging to a first taxon of yeasts that is resistant to an antifungal; a second group of microorganisms, belonging to a second taxon of yeasts that is different than the first taxon of yeasts, and that exhibits the mechanism of resistance to the antifungal exhibited by the first group; and a third group that is not resistant to the antifungal. | 11-01-2012 |
20120301908 | Method for Determining the Reliability of a Device for Measuring the Concentration of a Substance in Whole Blood, Method for Treating Whole Blood, Container and Kit - The present invention pertains to the field of measuring the concentration of a substance in whole blood and relates to a method for determining the reliability of a device for measuring the concentration of a substance in whole blood, and to a method for treating whole blood, wherein a cell-free blood fraction enriched with said substance and a suspension of blood cells are stored separately from each other. The invention also relates to a container and to a kit. | 11-29-2012 |
20120329083 | TEST UNIT CARTRIDGE FOR ANALYTE TESTING DEVICE - A test unit cartridge for holding a plurality of test units includes a first test unit that contains a first analyte sensor and a second test unit that contains a second analyte sensor. The first and second analyte sensors use first and second reagents to detect first and second analytes, respectively. The first analyte is different from the second analyte and the first and second test units are functionally non-fungible. The plurality of test units can also include a third test unit that contains two analyte sensors having two reagents for detecting two different analytes using one fluid sample. A method of using the test unit cartridge is also described, which comprises loading the cartridge into an analyte testing device and cocking an actuator of the device that is configured to (i) expose an analyte sensor of a test unit, (ii) ready a lancet, and (iii) advance a lancet cartridge. | 12-27-2012 |
20130029364 | METHOD FOR IMMOBILIZING GLUCOSE OXIDASE ON A SELF-ASSEMBLED MONOLAYER - Provided are a method for increasing an amount of glucose oxidase to be immobilized on the self-assembled monolayer and a sensor which comprises glucose oxidase immobilized with the method. The method of the disclosed technology is characterized by that one molecule of an amino acid is interposed between the self-assembled monolayer and the molecule of the glucose oxidase. | 01-31-2013 |
20130034870 | METHOD FOR BODILY FLUID SAMPLE TRANSFER DURING ANALYTE DETERMINATION - A method for the transfer of a bodily fluid sample (such as a whole blood sample) during the determination of an analyte (e.g., glucose) in the bodily fluid sample includes applying the bodily fluid sample to a sample collection reservoir of an analytical test strip (for example, an electrochemical-based analytical test strip). During such application, the sample collection reservoir is isolated from fluid communication with a determination chamber of the analytical test strip. The analytical test strip is subsequently inserted into a test meter such that the sample collection reservoir is placed into fluid communication with the determination chamber and such that at least a portion of the bodily fluid sample is consequentially transferred from the sample collection reservoir to the determination chamber. The method further includes determining the analyte in the bodily fluid sample transferred to the determination chamber. | 02-07-2013 |
20130034871 | HAND-HELD TEST METER AND ANALYTICAL TEST STRIP CARTRIDGE COMBINATION - A hand-held test meter and analytical test strip cartridge combination includes a hand-held test meter with a test meter housing and an extractor with a test strip engagement feature, while the analytical test strip cartridge includes a cartridge housing, a test strip presentation mechanism disposed within the cartridge housing, and a plurality of analytical test strips (each with at least one extractor engagement feature) disposed in the cartridge housing. Moreover, the test meter housing is configured for operative engagement with the cartridge housing, the test strip presentation mechanism is configured to present a single analytical test strip from the plurality of analytical test strips for engagement with the extractor, and the extractor and test meter housing are configured such that the extractor is operatively extendable from the test meter housing into the cartridge housing upon engagement of the meter housing with the cartridge housing. In addition, the extractor is also configured such that, upon operative extension, the extractor mechanically engages with the analytical test strip presented by the test strip presentation mechanism via engagement between the test strip engagement feature and the extractor engagement feature, and such that, upon disengagement of the test meter housing from the cartridge housing, the extractor removes the mechanically engaged analytical test strip from the cartridge housing and retracts into the test meter housing. | 02-07-2013 |
20130034872 | HAND-HELD TEST METER AND ANALYTICAL TEST STRIP CARTRIDGE ASSEMBLY WITH DESICCANT VIAL - A hand-held test meter and analytical test strip cartridge assembly combination includes a hand-held test meter with a test meter housing and an extractor with a test strip engagement feature, while the analytical test strip cartridge assembly includes a desiccant vial and an analytical test strip cartridge with a cartridge housing, a test strip presentation mechanism disposed within the cartridge housing, and a plurality of analytical test strips (each with at least one extractor engagement feature) disposed in the cartridge housing. The test meter housing is configured for operative engagement with the cartridge housing and the test strip presentation mechanism is configured to present a single analytical test strip from the plurality of analytical test strips for engagement with the extractor. Moreover, the analytical test strip cartridge is configured for operative disposition in the desiccant vial. | 02-07-2013 |
20130065261 | MODIFIED GLUCOSE DEHYDROGENASE GENE - The purpose of the present invention is to provide an FAD-conjugated glucose dehydrogenase that is hard to be inhibited by the inhibitors such as 1,10-phenanthroline. | 03-14-2013 |
20130084589 | HAND-HELD TEST METER WITH PHASE-SHIFT-BASED HEMATOCRIT MEASUREMENT CIRCUIT - A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing; a microcontroller block disposed in the housing; and a phase-shift-based hematocrit measurement block. The phase-shift-based hematocrit measurement block includes a signal generation sub-block, a low pass filter sub-block, an analytical test strip sample cell interface sub-block, a transimpedance amplifier sub-block, and a phase detector sub-block. In addition, the phase-shift-based hematocrit measurement block and microcontroller block are configured to measure the phase shift of a bodily fluid sample in a sample cell of an analytical test strip inserted in the hand-held test meter and the microcontroller block is configured to compute the hematocrit of the bodily fluid sample based on the measured phase shift. | 04-04-2013 |
20130084590 | ANALYTICAL TEST STRIP WITH BODILY FLUID PHASE-SHIFT MEASUREMENT ELECTRODES - An analytical test strip (“ATS”) for use with a hand-held test meter (“HHTM”) in the determination of an analyte in a bodily fluid sample (“BFS”) includes a first patterned conductive layer with a working electrode and a reference electrode, as well as a method for determining an analyte in BFS. The ATS also includes an enzymatic reagent layer disposed on the working electrode, a patterned spacer layer disposed over the first patterned conductive layer and configured to define a sample chamber (“SC”) within the ATS, and a second patterned conductive layer disposed above the first patterned conductive layer. The second patterned conductive layer includes a first phase-shift measurement electrode and a second phase-shift measurement electrode, which electrodes are disposed in the SC and are configured to measure, along with the HHTM, a phase shift of an electrical signal forced through a BFS introduced into the SC during the ATS' use. | 04-04-2013 |
20130095510 | ELECTROCHEMICAL ANALYTE MEASUREMENT METHOD AND SYSTEM - Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a first test voltage between a reference electrode and a second working electrode and applying a second test voltage between the reference electrode and a first working electrode; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing an analyte is applied to the test strip; measuring a fifth test current at the first working electrode; estimating a hematocrit-corrected analyte concentration from the first, second, third, fourth and fifth test currents; and annunciating the hematocrit-corrected analyte concentration. | 04-18-2013 |
20130102016 | Glucose Dehydrogenase - A modified pyrroloquinoline quinone glucose dehydrogenase that exhibits a high selectivity for glucose is provided. A modified pyrroloquinoline quinone glucose dehydrogenase is disclosed in which the amino acid residue G at Position 99 of a pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 1, or the amino acid residue G at Position 100 of the pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 3, is substituted by the amino acid sequence TGZN (where Z is SX, S, or N and X is any amino acid residue). The modified PQQGDH of the present invention may additionally comprise one or more mutations selected from the group consisting of Q192G, Q192A, or Q192S; L193X; E277X; A318X; Y367A, Y367F, or Y367W; G451C; and N452X (where X is any amino acid residue). | 04-25-2013 |
20130109039 | METHODS AND MATERIALS FOR MODULATING START-UP TIME AND AIR REMOVAL IN DRY SENSORS | 05-02-2013 |
20130109040 | IN VITRO POINT-OF-CARE SENSOR AND METHOD OF USE | 05-02-2013 |
20130115642 | METHOD FOR SCREENING DIABETES TREATING AGENT - The present invention provides a method for screening a diabetes treating agent comprising the following steps: (a) preparing cells inside a culture medium; (b) treating the culture medium with a test substance; (c) treating the result of step (b) with a glucose derivative which is not metabolized; and (d) measuring the glucose derivative which has flowed into the cells, wherein the test substance is determined to be a diabetes treating agent if the test substance accelerates uptake of the glucose derivative in the cells. Therefore, the described pharmaceutical composition, including a triazin-based compound as an active ingredient, can be useful for application in preventing or treating diabetes. | 05-09-2013 |
20130122531 | NANOSTRUCTURED COMPOSITE MATERIAL AND BIOSENSOR COMPRISING IT - A nanostructured composite is provided which comprises a matrix comprising carbon nanofibers, and a biochemical receptor, especially an enzyme, immobilized in the matrix, where the carbon nanofibers have been subject to an oxidation treatment. In a preferred embodiment, the nanostructured composite further comprises a biomimetically synthesized silica matrix. | 05-16-2013 |
20130122532 | Methods of Improving Auto-Coding Capabilities for Biosensors and Devices for Same - The present invention discloses a biological measuring device with auto coding capabilities. In accordance with one embodiment of the present invention, the biological measuring device with auto coding capabilities may include a test strip associated with a code pattern; and a code reader electrically coupled to the test strip to read the code pattern, wherein the code reader is configured to read an output from the code pattern consisted of a first logical value, a second logical value, and a third logical value. | 05-16-2013 |
20130143246 | HAND-HELD TEST METER WITH ANALYTICAL TEST STRIP EJECTION MECHANISM - A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample (e.g., a whole blood sample) includes a housing, with an outer surface, and an analytical test strip ejection mechanism (“ATSEM”). The ATSEM has an actuation button disposed in the outer surface of the housing, a motion amplification and rotation assembly (“MA&RA”) operatively connected to the actuation button and a test strip slider (“TSS”) operatively connected to the MA&RA. The actuation button is configured for movement by a user's digit in a first direction and the MA&RA and TSS are configured to convert the movement in the first direction into amplified movement of the TSS in a second direction with the second direction being rotated with respect to the first direction. Moving the TSS in the second direction from the engaged state to an ejected state ejects the strip. | 06-06-2013 |
20130149728 | Oral Fluid Sample Collection Device With Indicator and Method - Provided are methods and devices used for determining the presence or absence of a contaminant in the sample of oral fluid. The method involves contacting a substrate having a detectable reporter with a sample of oral fluid and, based on determining a signal from the detectable reporter determining the presence or absence of a contaminant in the sample of oral fluid. The invention is useful for detecting lactose, milk, colostrum, blood, hemoglobin, whole cells, and combinations thereof. The method can be used for detecting oral contaminants in oral fluid samples obtained from any mammal, including neonatal ungulates. | 06-13-2013 |
20130171675 | MEASURING DEVICE AND MEASURING METHOD - The device enables measurement of both of blood glucose level and hemoglobin A1c level, being small-sized and thus portable, allowing the measurement of a small amount of a specimen and, being usable in POC. The device comprises: a test-piece-mounting section ( | 07-04-2013 |
20130183699 | METHOD OF DIFFERENTIATING BETWEEN BLOOD AND CONTROL SOLUTIONS CONTAINING A COMMON ANALYTE - Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples. | 07-18-2013 |
20130203093 | FLAVIN-BINDING GLUCOSE DEHYDROGENASE - The invention provides a flavin-binding glucose dehydrogenase exhibiting reduced fluctuation of activity depending on temperature environment, and a method for measuring glucose concentration using the flavin-binding glucose dehydrogenase. The flavin-binding glucose dehydrogenase has the following properties (1) to (3): (1) activity: which exhibits glucose dehydrogenase activity in the presence of an electron acceptor; (2) substrate specificity: which exhibits an activity of 10% or less against maltose, D-galactose, D-fructose, sorbitol, lactose and sucrose when the activity against D-glucose is defined as 100%; and (3) temperature characteristics: which exhibits lower fluctuation of activity in a wide temperature range of 10 to 50° C. | 08-08-2013 |
20130203094 | Devices and Formulations for Detecting, Screening and Monitoring Levels of Certain Constituents in Bodily Fluids and Method - A device and method are disclosed for use in the conduct of a non-invasive analysis of a bodily fluid to determine the presence and level of a certain constituent carried by the bodily fluid, which analysis utilizes an indicator formulation that changes color in response to exposure to the constituent to provide a visible indication of the presence and level of the constituent carried by the bodily fluid. A stabilizing formulation is carried in a vessel for mixing with a sample of the bodily fluid to be analyzed. The stabilizing formulation includes a first component for promoting formation of a film, a second component for adjusting the pH of the sample and inhibiting microbial digestion of the certain constituent carried by the bodily fluid, and a third component for reducing interference of ascorbic acid present in the bodily fluid. Where the certain constituent is glucose, the stabilizing formulation includes a microbial digestion inhibitor. | 08-08-2013 |
20130210045 | BIOMARKER FOR FATIGUE, AND USE THEREOF - Ratios of measured values of glucose, citrate, and cis-aconitate in a biological sample obtained from a subject to measured values of glucose, citrate, and cis-aconitate in a biological sample obtained from a healthy subject are calculated, and the glucose ratio, the citrate ratio, and the cis-aconitate ratio are used to evaluate and/or assess fatigue. Similarly, an isocitrate ratio, a succinate ratio, a malate ratio, and a lactate ratio are calculated, and these ratios are used together with the three ratios to evaluate and/or assess fatigue. This makes it possible to objectively and easily diagnose and evaluate fatigue. | 08-15-2013 |
20130210046 | SCREENING METHODS FOR COMPOUNDS THAT MODULATE THE ACTIVITY OF G-PROTEIN COUPLED RECEPTORS - The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric G-protein coupled receptors (GPCRs) in eukaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or more preferably the use of these receptors for the identification of functional ligands is also encompassed. | 08-15-2013 |
20130217053 | ANALYTE MEASUREMENT METHOD AND SYSTEM WITH ERROR TRAPPING - Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. The methods and systems describe herein allow for trapping various errors during calculation of the analyte due to variations in the structure and materials making up the test strip and ambient temperatures. | 08-22-2013 |
20130217054 | HYBRID STRIP - A method of determining concentrations of a plurality of analytes from a single blood sample placed in a single opening. A portion of the single blood sample is absorbed by a test matrix that includes a plurality of layers and a chromogenic agent. A colored response is generated by the test matrix. The colored response is proportional to the concentration of a first analyte. A portion of the single blood sample is drawn into a capillary tube and placed in contact with an electrode and a counter-electrode. An electrical property of the single blood sample is analyzed through the electrode and counter-electrode. The electrical property is proportional to the concentration of a second analyte in the single blood sample. | 08-22-2013 |
20130260403 | IDENTIFICATION OF PRE-DIABETES USING A COMBINATION OF MEAN GLUCOSE AND 1,5-ANHYDROGLUCITOL MARKERS - Described herein is a method for determining the disease state in a patient using combined mean glucose measurements and 1,5-anhydroglucitol to identify individuals at risk for developing diabetes. The ratio of mean glucose measurements to 1,5-anhydroglucitol correlates significantly better to maximal levels of postmeal glucose levels and related measurements, than mean glucose measurements or 1,5-anhydroglucitol correlate independently. | 10-03-2013 |
20130288282 | Temperature-Adjusted Analyte Determination For Biosensor Systems - A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature. | 10-31-2013 |
20130288283 | METHOD FOR MEASURING COMPONENT TO BE MEASURED - The present invention provides a method for measuring a component to be measured in a sample, comprising converting the component to be measured in the sample into hydrogen peroxide and measuring the formed hydrogen peroxide in the presence of an α-keto acid using an oxidative-coloring chromogen. The present invention also provides a method for suppressing the influence of a peroxide on a method of converting a component to be measured in a sample into hydrogen peroxide and measuring the formed hydrogen peroxide using an oxidative-coloring chromogen, the suppression method comprising using an α-keto acid. The measuring method and the suppression method of the present invention using an α-keto acid suppress the influence of a peroxide to give an accurate measurement of the component to be measured in the sample. | 10-31-2013 |
20130337481 | ASSAY METHOD - The invention provides an assay method for determining a level of haptoglobin in a sample comprising the steps of: (i) mixing haemoglobin with the sample to be assayed so as to form a haptoglobin-haemoglobin complex with haptoglobin present in the sample; (ii) contacting the product of step (i) with reagents for generating hydrogen peroxide and one or more chromogens which undergo a spectroscopically detectable change when peroxidase activity is present, in the presence of a buffer, under conditions in which hydrogen peroxide is generated from said reagents and forms a substrate for the peroxidise activity of the haptoglobin-haemoglobin complex present, and wherein the pH of the buffer is within a range which is sufficiently low that the peroxidise activity of any uncomplexed haemoglobin is substantially suppressed but sufficiently high that hydrogen peroxide generation occurs; (iii) determining the peroxidase activity of the haptoglobin-haemoglobin complex by measuring the change in an optical property of the reaction mixture; and (iv) correlating the level of peroxidise activity of the haptoglobin-haemoglobin complex with the amount of haptoglobin in the sample. A kit for use in such a method is also provided. | 12-19-2013 |
20140024060 | USE OF HYDROGELS FOR BIOSENSORS HAVING ELEVATED SENSITIVITY - The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand. | 01-23-2014 |
20140030748 | METHOD AND SYSTEM TO MANAGE DIABETES USING MULTIPLE RISK INDICATORS FOR A PERSON WITH DIABETES - Described are methods and systems to annunciate to the patient of the components involved in each of the daily risk range based on the glucose measurements to assist the patient in identification of whether it is hypoglycemia or hyperglycemia are driving the daily risk range of the measured glucose values. | 01-30-2014 |
20140030749 | MODIFIED GLUCOSE DEHYDROGENASE - The present invention relates to glucose dehydrogenase [NAD(P) | 01-30-2014 |
20140045202 | Analyte Sensors and Methods for Making and Using the Same - The present disclosure provides an analyte sensor that includes a conductive calibration pattern which provides species-specific calibration information to a meter. Also provided, are analyte sensors comprising a layer of absorbent material disposed on a first major surface of a first substrate and/or a second major surface of a second substrate. Methods for making and using the analyte sensors are also provided. | 02-13-2014 |
20140045203 | TEST ELEMENT FOR DETECTING AN ANALYTE IN A SAMPLE - The invention relates to a test element for detecting at least one analyte in a sample, in particular for detecting at least one metabolite in a bodily fluid. The test element comprises at least one test field with a test field surface. The test field comprises at least one detection reagent that is adapted to undergo a detectable reaction in the presence of the analyte. The test element further comprises at least one distribution element that has at least one distribution surface facing the test field surface. Between the distribution surface and the test field surface is at least one capillary gap, wherein the capillary gap is adapted to allow a layer of the sample with a layer thickness of no more than 50 μm to form within the capillary gap. | 02-13-2014 |
20140106384 | Cellulase Assay - The invention involves the development of a substrate and assay procedure for the scientific measurement of cellulase in admixture with other enzymes active on cellulose or 1,4-β-D-gluco-oligosaccharides, or in various levels of purity of the cellulase. This substrate being characterised by the fact that it contains at least 2 glucose units linked β-1,4-, with the reducing end glucose unit linked β- or α- to a compound which exhibits an optically measurable change on cleavage of the bond between it and the adjacent D-glucosyl residue and the non-reducing terminal D-glucosyl unit is covalently linked to a blocking substituent which inhibits cleavage by exo-acting enzymes of the bond between the terminal and non-reducing end, penultimate D-glucose unit. | 04-17-2014 |
20140120564 | NON-INVASIVE MEASUREMENT OF ANALYTES - This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin. | 05-01-2014 |
20140127728 | REAGENT MATERIALS AND ASSOCIATED TEST ELEMENTS - Reagent materials and associated test elements are provided. In one embodiment, a test element having dual functionality includes a first coenzyme-dependent enzyme or a substrate for the first enzyme, a second coenzyme-dependent enzyme or a substrate for the second enzyme, and a coenzyme selected from the group consisting of thio-NAD, thio-NADP, and a compound according to formula (I). In one aspect, the first analyte is hydroxybutyrate and the first enzyme is a hydroxybutyrate dehydrogenase, and the second analyte is glucose and the second enzyme is a glucose dehydrogenase or a glucose oxidase. Other aspects of the subject application are directed to unique reagent materials. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings. | 05-08-2014 |
20140127729 | METHOD FOR COLLECTING MEDICAL DATA AND ASSOCIATED SYSTEM - A glucometer is provided, comprising a reader configured to analyze a blood sample, a transmitter configured to wirelessly transmit data, encoded within an audio signal, regarding results of the analysis, and a controller configured to facilitate the encoding. | 05-08-2014 |
20140134655 | SYSTEM AND METHOD FOR DETECTION OF SAMPLE VOLUME DURING INITIAL SAMPLE FILL OF A BIOSENSOR TO DETERMINE GLUCOSE CONCENTRATION IN FLUID SAMPLES OR SAMPLE FILL ERROR - Described are methods and systems to allow for a determination of when a sample has substantially stopped filling a test chamber so that a test sequence timer can be initiated at the appropriate time point for assaying of a biosensor. This determination can also be used to evaluate whether the biosensor has been filled with additional fluid samples after an initial fill of the biosensor. These methods and systems allow for a more accurate analyte test result. | 05-15-2014 |
20140141460 | Method of Conducting an Assay - The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties. | 05-22-2014 |
20140147872 | OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE IN CONTROL SOLUTIONS FOR BIOSENSORS - Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample. | 05-29-2014 |
20140154717 | METHOD FOR DETECTING CANCER CELL USING FLUORESCENTLY LABELED L-GLUCOSE DERIVATIVE, AND CANCER CELL-IMAGING AGENT COMPRISING FLUORESCENTLY LABELED L-GLUCOSE DERIVATIVE - The purpose of the present invention is to provide a method for highly accurately detecting a cancer cell. The method of the present invention is characterized by comprising imaging with the use of a fluorescently labeled L-glucose derivative. By using the method and imaging agent according to the present invention, a high contrast between a cancer cell and a normal cell can be obtained compared with the case that imaging is conducted with the use of a fluorescently labeled D-glucose derivative. According to this method, moreover, no fasting is needed for the determination. Thus, the imaging can be quickly carried out without imposing a burden on a patient. | 06-05-2014 |
20140154718 | Biosensors and Porous Particle Reagent Compositions - A reagent composition for a biosensor sensor strip is disclosed that provides for rapid rehydration after drying. The composition includes porous particles and is preferably formed as a colloidal suspension. The dried reagent composition including porous particles may provide analytically useful output from the sensor strip in a shorter time period than observed from dried reagent compositions using solid particles. The output signal from the porous particle compositions may be correlated to the analyte concentration of a sample within about two seconds. In this manner, an accurate concentration determination of an analyte concentration in a sample may be obtained in less time than from sensor strips including conventional compositions. The reagent composition including the porous particles also may allow for the redox reaction between the reagents and the analyte to reach a maximum kinetic performance in a shorter time period than observed from conventional sensor strips. | 06-05-2014 |
20140154719 | METHOD OF DIFFERENTIATING BETWEEN BLOOD AND CONTROL SOLUTIONS CONTAINING A COMMON ANALYTE - Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples. | 06-05-2014 |
20140178909 | Method for Improving Measurement Accuracy and Devices and Systems Related Thereto - The present disclosure relates to methods and devices for providing accurate measurement of a property of a sample. The method comprises obtaining a plurality of independent measurements of the property. The plurality of values of the property of the sample obtained by the plurality of independent measurements is compared to determine whether one or more of the values is an outlier. | 06-26-2014 |
20140186866 | Glucose Control Test Strip - A control test strip for glucose that includes a cover that forms a fluid path when affixed to the test strip substrate. The fluid path includes a glucose deposit area formed by drying a glucose solution on to the cover or onto the test strip substrate. The control test strip further includes a pair of electrodes having a first end positioned within an enzyme coating area and a second end positioned to deliver an electrical signal to the glucose meter. The enzyme coating area also lies within the fluid path. When a user places a drop of water at the opening of the fluid path, capillary action pulls the water into the fluid path, mixing the water with the dried glucose so that a solution having a known glucose concentration is formed. This glucose solution then mixes with the enzyme and a reading is made by the glucose meter. | 07-03-2014 |
20140212903 | AZO MEDIATORS AND METHODS OF USE THEREOF - Azo compounds are disclosed that do not form azoxy dimers and that do not have any reactive nitroso groups. Also disclosed are use of the azo compounds as mediators in optical and electrochemical diagnostic methods, as well as detection reagents, kits and test elements that include such azo compounds and that can be used in the diagnostic methods. | 07-31-2014 |
20140255962 | SYMMETRICAL TEST ELEMENT FOR DETECTING AN ANALYTE - Test elements are disclosed for detecting at least one analyte in a body fluid. The test element include at least one strip-shaped carrier element and at least one test field having at least one test chemistry for detecting the analyte. The test element has a symmetrical shape such that the test element may be inserted in one of at least two different correct measurement orientations into a test element receptacle of a testing device, which includes a detection device. In the different orientations, at least one analyte-induced change in the test chemistry of the test field is detectable. Test systems including the test elements and methods of detecting at least one analyte in the body fluid using the test elements also are disclosed. | 09-11-2014 |
20140273041 | BOTTLED GLUCOSE SENSOR WITH NO HANDLING - A device and system for automatic handling of a sensor strip by a part of meter includes a sensor strip having a first section, a second section, and an intermediate section. The sensor strip includes at least a first opening about a first end thereof and a second opening about a second end thereof. A meter part includes a pair of pivoting catches configured to engage and grasp a sensor strip from a container containing a plurality of sensor strips. The sensor strip may thus be removed from a container for testing without need for manual handling of the strip by a user. | 09-18-2014 |
20140273042 | PREDICTIVE CALIBRATION - A portable medical monitor system generates a current calibration curve for generating the estimate of the level of an analyte, such as glucose, being monitored. The current calibration curve is based on at least two measured data values of the level being monitored. The system determines a transformation function based on the calibration curve and at least one preceding calibration curve such that the transformation function produces a predictive calibration curve, and generates an estimated level value of the level being monitored, based on sensor output from a sensor associated with the portable medical monitor system, in accordance with the predictive calibration curve. | 09-18-2014 |
20140273043 | TRI-COLOR DUAL GLUCOSE AND OXYGEN SENSORS AND METHODS OF PREPARING AND USING THEM - The present disclosure relates to an optical fluorescence sensor comprising a probe for sensing glucose, an intra-reference probe, and a matrix. The present disclosure also relates to an optical fluorescence dual sensor comprising a probe for sensing glucose, a probe for sensing oxygen, an intra-reference probe, and a matrix. The present disclosure additionally relates to methods of preparing these sensors and methods of using them. | 09-18-2014 |
20140287445 | FLAVIN-BINDING GLUCOSE DEHYDROGENASE, METHOD FOR PRODUCING FLAVIN-BINDING GLUCOSE DEHYDROGENASE, AND GLUCOSE MEASUREMENT METHOD USING THEREOF - A flavin-binding glucose dehydrogenase (FAD-GDH), which in addition to having high substrate specificity and adequate desirable heat stability, is suitable for efficient production, preferably using | 09-25-2014 |
20140302541 | METHODS OF DETERMINING AN ANALYTE CONCENTRATION, AS WELL AS DEVICES AND TEST ELEMENTS INCORPORATING THE SAME - Methods, devices and test elements are disclosed for detecting at least one analyte in a sample. The methods, devices and test elements are used for detecting one or more analytes such as metabolites in body fluids, especially glucose. The methods, devices and test elements correct for an interfering variable such as temperature and or hematocrit in a test element system via a correction factor based upon diffusion of a diffusable label. | 10-09-2014 |
20140302542 | FLAVIN-BINDING GLUCOSE DEHYDROGENASE HAVING IMPROVED SUBSTRATE SPECIFICITY - A flavin-binding glucose dehydrogenase having high substrate specificity for D-glucose and decreased reactivity to D-xylose and/or maltose. More specifically, a flavin-binding glucose dehydrogenase having one or more amino acid substitutions at a position corresponding to position 78, position 79, position 81, position 121, position 122, position 123, position 569 and position 612 of | 10-09-2014 |
20140308690 | DEVICES CONTAINING DRIED REAGENTS FOR RECONSTITUTION AS CALIBRATION AND/OR QUALITY CONTROL SOLUTIONS, AND METHODS OF PRODUCTION AND USE THEREOF - Devices contain dried reagents that may be reconstituted and used in the calibration and quality control of sensors. Methods of producing and using the devices are also disclosed. | 10-16-2014 |
20140322737 | FAST REACTION KINETICS OF ENZYMES HAVING LOW ACTIVITY IN DRY CHEMISTRY LAYERS - The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte. | 10-30-2014 |
20140356887 | GLUCOSE DEHYDROGENASE - Amino acid mutation(s) can be introduced to | 12-04-2014 |
20140363835 | COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION - Dry reagent compositions are disclosed for maintaining and preserving enzymatic activity. Also disclosed are test elements incorporating the same and methods of making and using the same for determining the presence or amount of an analyte in a body fluid sample. The dry reagent compositions can include components such as a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one optical change in an optical property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one compatible solute being ectoine or a derivative thereof. | 12-11-2014 |
20140377787 | THREE DIMENSIONAL LIGNOCELLULOSIC DETECTION DEVICE - A three dimensional lignocellulosic detection device includes a first lignocellulosic substrate and a second lignocellulosic substrate. When the first lignocellulosic substrate is in contact with a liquid specimen through capillary effect, the sample is absorbed into the second lignocellulosic substrate through the first lignocellulosic substrate, reacts with the detecting reagent on the second lignocellulosic substrate and makes a detection test. The three dimensional lignocellulosic detection device of the present invention have inherent advantages of the lignocellulosic such as natural material, low cost, easy manipulation and capillary effect and results in a good preventive diagnostic platform. Also, users may achieve preventive disease diagnostics without spending additional time and/or money. | 12-25-2014 |
20140377788 | BLOOD GLUCOSE MEASUREMENT UNIT, BLOOD GLUCOSE MEASUREMENT SYSTEM COMPRISING THE SAME, AND BLOOD GLUCOSE MEASUREMENT METHOD - A blood glucose measurement unit, a blood glucose measurement method, and a blood glucose measurement system comprising the same are disclosed. According to one aspect of the present invention, provided is a blood glucose measurement unit comprising: a transparent first substrate consisting of a blood inflow region into which blood flows and a reaction region connected to the blood inflow region which are formed on one surface thereof; a transparent second substrate coupled to the first substrate and comprising a blood aperture through which the blood flowing into the blood inflow region passes; and a reagent distributed to the reaction region so as to react with the blood glucose of the blood which has flown into the blood inflow region. | 12-25-2014 |
20140377789 | ASSAY AND METHOD FOR DETERMINING INSULIN-RESISTANCE - The present invention provides for a home test or a point of care test device that can both detect blood glucose and insulin levels and methods using said device. The device and methods can be used to aid diabetic patients and medical practitioners to fine tune insulin administration, and to monitor disease progression or treatment. | 12-25-2014 |
20150024422 | METHOD OF DETERMINATION OF RISK OF 2 HOUR BLOOD GLUCOSE EQUAL TO OR GREATER THAN 140 mg/Dl - This invention relates to methods for predicting likelihood of a subject having abnormal glucose tolerance based on analyzing a combination of three or more biomarkers relating to specific physiological processes. This invention also relates to methods of accessing insulin sensitivity in a subject based on analyzing a combination of three or more biomarkers relating to specific physiological processes. The method has a clinical utility in correct and quick assessment of a subject's glucose tolerance and risk of developing diabetes or cardio-diabetic conditions and comorbidities. | 01-22-2015 |
20150031059 | NOVEL GLUCOSE DEHYDROGENASE - An object of the present invention is to provide a novel glucose dehydrogenase, a method for producing the glucose dehydrogenase, and applications of the glucose dehydrogenase. The flavin-binding glucose dehydrogenase of the invention has the following characteristics (1) and (4): (1) Molecular weight: the molecular weight of a polypeptide moiety in the enzyme is about 68 kDa as measured by SDS-polyacrylamide electrophoresis; (2) Km value: the Km value for D-glucose is about 15 mM or less; (3) Temperature stability: stable at a temperature of 55° C. or less; and (4) pH stability: stable at a pH range of 3.0 to 8.5. | 01-29-2015 |
20150031060 | FAD-CONJUGATED GLUCOSE DEHYDROGENASE GENE - Disclosed herein are a gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase which can be characterized by reactivity to glucose, thermal stability, substrate-recognition performance, and low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; a method for the determination of glucose; a reagent composition for use in the determination of glucose; and a biosensor for use in the determination of glucose. An embodiment is a polynucleotide encoding an FAD-conjugated glucose dehydrogenase, comprising a polypeptide whose amino acid sequence comprises X1-X2-X3-X4-X5-X6, wherein X1 and X2 independently represent an aliphatic amino acid residue; X3 and X6 independently represent a branched amino acid residue; and X4 and X5 independently represent a heterocyclic amino acid residue or an aromatic amino acid residue. | 01-29-2015 |
20150037827 | ORGANIC THIN FILM TRANSISTORS AND THE USE THEREOF IN SENSING APPLICATIONS - The present invention relates to organic thin film transistors and the preparation and use thereof in sensing applications, and in particular in glucose sensing applications. | 02-05-2015 |
20150044711 | Glucose Dehydrogenase - A modified pyrroloquinoline quinone glucose dehydrogenase that exhibits a high selectivity for glucose is provided. A modified pyrroloquinoline quinone glucose dehydrogenase is disclosed in which the amino acid residue G at Position 99 of a pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 1, or the amino acid residue G at Position 100 of the pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 3, is substituted by the amino acid sequence TGZN (where Z is SX, S, or N and X is any amino acid residue). The modified PQQGDH of the present invention may additionally comprise one or more mutations selected from the group consisting of Q192G, Q192A, or Q192S; L193X; E277X; A318X; Y367A, Y367F, or Y367W; G451C; and N452X (where X is any amino acid residue). | 02-12-2015 |
20150050678 | MODULAR ANALYTICAL TEST METER - A modular analytical test meter includes a meter chassis or body and a plug-in analytical module that is electrically and mechanically attached in a releasable fashion to the meter chassis. When attached, the plug-in analytical module includes resident circuitry configured to measure for an analyte of interest from an analytical test strip, the module further including stored coded information such as firmware updates that can be utilized by the existing test meter without requiring replacement of an entire system. | 02-19-2015 |
20150064733 | GLYCOSYLATED MODIFIED FLAVIN ADENINE DINUCLEOTIDE-DEPENDENT GLUCOSE DEHYDROGENASES, COMPOSITIONS THEREOF AS WELL AS METHODS OF MAKING AND USING THE SAME - Compositions, devices, kits and methods are disclosed for assaying glucose with a glycosylated, modified flavin adenine dinucleotide-dependent glucose dehydrogenase (FAD-GDH), variant thereof or an active fragment thereof, where at least one asparagine residue at positions N2, N168 and N346 of mature, wild-type | 03-05-2015 |
20150072365 | MAGNETICALLY ALIGNING TEST STRIPS IN TEST METER - An analytical test meter includes a meter housing containing a test strip connector that includes at least two terminals. A processor is disposed within the meter housing, as well as a current generator that generates a magnetic field in association with one of the terminals for attracting a contact of an analytical test strip for alignment or retention therewith. Detection of the presence of an analytical test strip relative to an electrical contact can cause an increase in the intensity of the magnetic field. | 03-12-2015 |
20150111236 | Method and Device for Detecting an Analyte in a Body Fluid - A method for detecting at least one analyte in at least one sample of a body fluid is disclosed. Therein, at least one test element ( | 04-23-2015 |
20150118700 | MODIFIED AMADORIASE REACTING WITH FRUCTOSYL HEXAPEPTIDE - This invention provides an amadoriase having high reactivity with α-fructosyl hexapeptide (αF6P) derived from the β-chain amino terminus of glycated hemoglobin (HbAlc), which enables satisfactory quantification of αF6P cleaved from HbAlc. A novel amadoriase is derived from the amadoriase of the genus | 04-30-2015 |
20150125887 | METHOD FOR ESTABLISHING THE ANTI-DIABETIC POTENTIAL OF BITTER MELON - A method is disclosed for determining the hypoglycemic potential of | 05-07-2015 |
20150140584 | REAGENT MATERIALS AND ASSOCIATED TEST ELEMENTS - Reagent materials and associated test elements are provided. In one embodiment, a test element having dual functionality includes a first coenzyme-dependent enzyme or a substrate for the first enzyme, a second coenzyme-dependent enzyme or a substrate for the second enzyme, and a coenzyme selected from the group consisting of thio-NAD, thio-NADP, and a compound according to formula (I). In one aspect, the first analyte is hydroxybutyrate and the first enzyme is a hydroxybutyrate dehydrogenase, and the second analyte is glucose and the second enzyme is a glucose dehydrogenase or a glucose oxidase. Other aspects of the subject application are directed to unique reagent materials. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings. | 05-21-2015 |
20150298128 | COEXTRUDED PLASTIC CAPILLARY TUBE - Coextruded plastic capillary tube and method of manufacturing a coextruded tube for collecting a volume of liquid. The tube is disposable, inexpensive to manufacture and can reliably draw blood and other aqueous based fluids into the tube by capillary action, at a fluid uptake level comparable to glass and other commercially pre-treated plastic tubes, without requiring further interior coating. | 10-22-2015 |
20150347714 | MULTIFUNCTIONAL GLUCOSE MONITORING SYSTEM AND METHOD OF USING THE SAME - A multifunctional glucose monitoring system and method of measuring glucose level, determining insulin dosage, and indicating insulin dosage on a syringe is disclosed. The multifunctional glucose monitoring system includes standard functionality with respect to acquiring a blood glucose reading. However, in addition, the multifunctional glucose monitoring system includes a dosage algorithm for calculating an insulin dosage based on the blood glucose reading and any other useful parameters, and includes a built-in marking device for marking the calculated dosage level on the barrel of an insulin syringe that is installed in the body of the multifunctional glucose monitoring system. A method includes the steps of measuring the glucose level, determining an insulin dosage, and indicating the insulin dosage on a syringe. | 12-03-2015 |
20150361479 | IDENTIFICATION OF PRE-DIABETES USING A COMBINATION OF MEAN GLUCOSE AND 1,5-ANHYDROGLUCITOL MARKERS - Described herein is a method for determining the disease state in a patient using combined mean glucose measurements and 1,5-anhydroglucitol to identify individuals at risk for developing diabetes. The ratio of mean glucose measurements to 1,5-anhydroglucitol correlates significantly better to maximal levels of postmeal glucose levels and related measurements, than mean glucose measurements or 1,5-anhydroglucitol correlate independently. | 12-17-2015 |
20150369794 | Method for Identifying of a Biological Sample of a Mammal, Composition for use in this method and Kit for Performance of this Method - The invention relates to a method through which a biological sample of a mammal can be precisely assigned and identified, as well as a kit for performance of this method and a composition comprising at least one essentially non-metabolizable marker substance and a dye useable in the method and the kit. | 12-24-2015 |
20150369797 | METHOD FOR IMAGING CELL USING FLUORESCENCE-LABELED SUGAR DERIVATIVE HAVING COUMARIN DERIVATIVE BOUND THERETO, AND IMAGING AGENT - The present invention has an object of providing a sugar derivative emitting blue fluorescence color which can be used for imaging of cells or intracellular molecules and a method for imaging cells using the derivative. Further, the present invention has an object of providing a method for detecting cancer cells at high accuracy by imaging, and an imaging agent used for this method. The present invention provides a fluorescently labeled sugar derivative having 3-carboxy-6,8-difluoro-7-hydroxycoumarin or 3-carboxymethyl-6,8-difluoro-7-hydroxy-4-methylcoumarin as a fluorescent molecular group in its molecule, and a cell imaging agent and an imaging method using the derivative. Further, the present invention provides an imaging agent and an imaging method for cancer cells using an L-glucose derivative having the above-described fluorescent molecular group in its molecule. | 12-24-2015 |
20150369813 | ANALYTICAL TEST STRIP WITH TIERED CAPILLARY CHAMBER - An analytical test strip for the determination of an analyte (such as glucose) in, or a characteristic of, a bodily fluid sample includes an electrically-insulating base layer, a first patterned spacer layer disposed on the electrically-insulating base layer, a second patterned spacer layer disposed on the first patterned spacer layer; and a top hydrophilic layer disposed on the second patterned spacer layer. In addition, the electrically-insulating base layer, the first and second patterned spacer layers and the top hydrophilic layer define a tiered capillary chamber(s) that has a first tiered capillary chamber portion defined in the first patterned spacer layer and a second tiered capillary chamber portion defined in the second patterned spacer layer. Moreover, the first tiered capillary chamber portion and the second tiered capillary chamber portion are in direct fluidic communication with one another. | 12-24-2015 |
20150376594 | STABILIZATION OF BIOMOLECULES BY ATTACHMENT OF RESPONSIVE POLYMERS AND SENSORS THEREOF - The present invention provides a biomolecule conjugate having one or more functionalized biomolecules wherein the biomolecule is functionalized with one or more reactive sites, and at least one polymer capable of undergoing a polymer growth reaction, wherein the polymer is attached to at least one of the reactive sites of the functionalized biomolecule and wherein the polymer envelopes the functionalized biomolecule to form a reversible nanoparticle structure which protects the biomolecule by dynamically collapsing to preserve the biomolecule when an adverse environmental stimulus is present. A method of protecting a biomolecule from environmental conditions is also provided. | 12-31-2015 |
20160002609 | Glucose Oxidase Variants, As Well As Compositions, Devices, Kits and Uses Thereof - Novel glucose oxidase variants are disclosed that have besides the two substitutions T30V and I94V according to SEQ ID NO:1, additionally at least one further amino acid substitution in the polypeptide sequence in any of the positions S53; A137; A173; A332; F414 and V560. The glucose oxidase variants herein exhibit specificity for glucose and significantly reduced oxygen consumption rates and/or increased enzyme activity for electron mediators other than oxygen. Also provided are assay devices incorporating at least one of the GOx variants herein for improved blood glucose measurements. | 01-07-2016 |
20160054301 | BIOLOGICAL ASSAY OF PEPTIDOGLYCANS - The present invention relates to a biological method for assaying peptidoglycans (PGN) in a sample, particularly a sample of glucose polymers. The PGN assay includes: a) treating the glucose polymer sample by sonication, heating, and/or alkalizing; b) placing the treated sample or a dilution thereof in contact with a recombinant cell expressing an exogenous TLR2 (toll-like receptor 2) and a reporter gene directly dependent on the signaling pathway associated with the TLR2. The reporter gene codes for a colored or fluorescent protein or for a protein the activity of which is measurable with or without a substrate; c) measuring the reporter gene signal; and d) determining the amount of PGN in the sample using a standard curve of the correlation between the amount or PGN and the strength of the reporter gene signal. | 02-25-2016 |
20160054329 | NOVEL SENSOR SYSTEM UTILIZING PIEZOELECTRIC MICROCANTILEVER COUPLED WITH RESONATING CIRCUIT - An interchangeable sensor system is described, including: a microcantilever including a beam anchored at a first end, the beam being free to vibrate on another end, wherein a piezoelectric layer is deposited on a surface of the beam; an input configured to receive a voltage from a voltage source for applying voltage to the piezoelectric layer; and a resonating circuit including: the piezoelectric layer, configured as a capacitor of the resonant circuit; and one or more additional electrical elements; wherein the voltage source is configured to apply a first AC voltage under a first condition for actuating the microcantilever at a first mechanical resonating frequency of the microcantilever and a second AC voltage under a second condition for actuating the microcantilever at a second electrical resonating frequency of the resonating circuit. Method of using the sensor system is also described. | 02-25-2016 |
20160083777 | TEST ELEMENTS FOR DETERMINING AN ANALYTE CONCENTRATION THAT INCLUDE CORRECTION INFORMATION FOR AT LEAST ONE INTERFERING VARIABLE - Test elements are disclosed for detecting at least one analyte concentration in a sample. The test elements are used for detecting one or more analytes such as metabolites in body fluids, especially glucose. The test elements correct for an interfering variable such as temperature and or hematocrit in a test element system via a correction factor based upon diffusion of at least one diffusable label. | 03-24-2016 |
20160108456 | METHOD FOR ESTABLISHING THE ANTI-DIABETIC POTENTIAL OF BITTER MELON - A method is disclosed for determining the hypoglycemic potential of | 04-21-2016 |
20160109436 | SENSOR HAVING CHEMICAL INSPECTING FUNCTION AND THE INSPECTING MATERIAL CONTAINED THEREIN - The present invention provides a sensor having chemical inspecting function and the inspecting material contained therein. In simple terms, one of the major features of the present invention is to reduce the detection area contacted with air between the gel and the inspecting material so as to slow down the degradation thereof. The other feature of the invention is to provide the detailed compositional parameters required by the inspecting material in the said process so as to obtain a balanced value between the cost and the visibility. By the present invention, the problem of short retention period of the personal hygiene item is herein solved. | 04-21-2016 |
20160168544 | NOVEL GLUCOSE DEHYDROGENASE | 06-16-2016 |
20160186229 | METHODS AND APPARATUS FOR DETERMINING ANALYTE IN A SAMPLE USING A SENSOR HAVING ELECTRODES WHICH ARE PROVIDED WITH AN ENZYME AND A MEDIATOR - The invention relates to a method of and apparatus for determining concentration of an analyte, such as glucose, in a fluid sample, such as body fluid or control solution, using a mediated redox reaction. In particular, the method relates to mitigation of the effects of haematocrit on the response of sensor device used in such a method or apparatus. The invention describes a method of determining concentration of an analyte in a fluid sample deposited on a sensor device having a working electrode and a counter electrode, in which the electrodes are provided with an enzyme and a mediator for carrying out a mediated redox reaction, the method comprising: applying a first oxidising potential between the working and counter electrodes during a first time period; applying a second reducing potential between the working and counter electrodes during a second time period; determining a reaction parameter, the reaction parameter being indicative of the concentration of reduced mediator at the counter electrode after commencement of the second time period; using the reaction parameter to determine the concentration of analyte. | 06-30-2016 |
20160252515 | PERSONAL GLUCOSE METERS FOR DETECTION AND QUANTIFICATION OF ENZYMES AND METABOLITES BASED ON COENZYME DETECTION | 09-01-2016 |
20160377634 | APPARATUS, METHOD, AND PROGRAM FOR COMPONENT MEASUREMENT - Provided is a component measuring apparatus configured to determine a functional form that describes wavelength characteristics of a variation attributable to scattering (S (λ)). The apparatus then determines unknown one or more coefficients (p, q) based on a first relational expression that involves a variation attributable to absorption (H (λ | 12-29-2016 |
20180024113 | THERMOELECTRIC SENSOR FOR ANALYTES IN A GAS AND RELATED METHOD | 01-25-2018 |