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CONDITION RESPONSIVE CONTROL PROCESS

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435 - Chemistry: molecular biology and microbiology

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DocumentTitleDate
20130045473Laboratory Apparatus and Method for Handling Laboratory Samples - The invention relates to a laboratory apparatus for handling laboratory samples, in particular for adjusting the temperature of a biochemical sample arranged in a sample vessel element, having a carrier device for carrying the sample vessel element, an electrical control device set up for controlling an operating parameter of the laboratory apparatus that controls this handling, and a sensor device for recording a measured value, by which a geometrical property of the a sample vessel element can be determined, the a sensor device being signal-connected to the electrical control device, the electrical control device being set up for controlling the handling of the laboratory sample in dependence on the measured value and the set operating parameter by the control step; and a method for handling at least one laboratory sample by means of a laboratory apparatus and to a computer program product for performing the method.02-21-2013
20130078610METHOD AND SYSTEM FOR THERMAL CYCLING OF MICROFLUIDIC SAMPLES - A thermal cycler for a microfluidic device includes a controller operable to provide a series of electrical signals, a heat sink, and a heating element in thermal communication with the heat sink and operable to receive the series of electrical signals from the controller. The thermal cycler also includes a thermal chuck in thermal communication with the heating element. The thermal chuck comprises a heating surface operable to make thermal contact with the microfluidic device. The heating surface is characterized by a temperature ramp rate between 2.5 degrees Celsius per second and 5.5 degrees Celsius per second and a temperature difference between a first portion of the heating surface supporting a first portion of the microfluidic device and a second portion of the heating surface supporting a second portion of the microfluidic device is less than 0.25° C.03-28-2013
20130078609THERMAL CYCLING - A processing apparatus includes a carrier receiving region configured to receive a sample carrier with at least one channel that carries at least one sample. The apparatus further includes a thermal control device configured to thermal cycle the sample carrier when the sample carrier is installed in the carrier receiving region, thereby thermal cycling the sample carried therein. The apparatus further includes a thermal control system configured to control the temperature control device based on a predetermined set of target sample temperatures and a temperature map, which maps the predetermined set of target sample temperatures to a set of temperatures of the temperature control device. The set of temperatures of the temperature control device is different from the predetermined set of target sample temperatures, and the set of temperatures of the temperature control device thermal cycle the sample carrier with the temperatures of the predetermined set of target sample temperatures.03-28-2013
20100075296Thermal cycling by positioning relative to fixed-temperature heat source - A thermal cycling system and method are provided herein, The thermal cycling system for performing a biological reaction at two or more different temperatures comprises: a) a heat source for setting at a fixed temperature; b) a reaction vessel containing material upon which the biological reaction is to be performed; c) mechanically-operable means for altering the relative position of the heat source and the reaction vessel so that reaction vessel first achieves and maintains a desired first temperature in the reaction vessel for starting the carrying out of the biological reaction, and then for altering the relative position of the heat source and the reaction vessel so that reaction vessel then achieves and maintains a second temperate for continuing the carrying out of the biological reaction on the biological material, and d) temperature-sensing means operatively associated with the reaction vessel for controlling the altering of the relative position of the heat source and the reaction vessel so that the reaction vessel achieves and maintains the desired second temperature in the reaction vessel.03-25-2010
20130084559Methods of Sustaining Culture Viability - The present invention relates to methods for sustaining a microbial culture during periods of limited substrate supply. In accordance with the methods of the invention, a microbial culture comprising carboxydotrophic bacteria can be sustained during periods of limited substrate supply by maintaining the temperature of the microbial culture at a temperature below an optimum operating temperature. Examples of periods of limited substrate supply include when the microbial culture is transported to a remote location or during time when it is stored.04-04-2013
20130034842Systems and Methods for Analyzing Microbiological Substances - Disclosed are systems and methods for monitoring a fluid for the purpose of identifying microbiological content and/or microorganisms and determining the effectiveness of a microbiological treatment. One method of monitoring a fluid includes containing the fluid within a flow path, the fluid including at least one microorganism present therein, optically interacting electromagnetic radiation from the fluid with at least one integrated computational element, thereby generating optically interacted light, receiving with at least one detector the optically interacted light, and generating with the at least one detector an output signal corresponding to a characteristic of the fluid, the characteristic of the fluid being a concentration of the at least one microorganism within the fluid.02-07-2013
20090155765Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control - A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.06-18-2009
20090136913Gravity-Assisted Mixing Methods - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.05-28-2009
20130029315Control of Biogas Plants - A method and an apparatus for producing biogas from organic matter including a container (01-31-2013
20130029314Method and Apparatus for Producing Biogas - A method and apparatus for producing biogas from organic matter including a container (01-31-2013
20120225420BIO VAPOR STIMULATION SYSTEM - The organic material in a landfill's incoming solid waste is converted into a useful biogas (methane). A bio vapor stimulation system comprises components for mixing bacteria and nutrients and for growing bacteria, as well as process sensors, and a delivery system to provide an appropriate balance of: (1) anaerobic bacteria, (2) nutrients, and (3) humidification. Measurements of landfill site conditions, landfill gas, landfill gas condensate for temperature, pH, alkalinity, COD/BOD and gas composition, oxidation-reduction potential (ORP), volatile acid concentration, and/or other parameters are used as process control inputs. Based upon these measured indicators of the health and status of the anaerobic bacteria community within the site, various process changes may be administered such as bacteria composition, additives, nutrient composition and quantity, and temperature and ph of the liquid being fed into a carrier gas for site humidification, thereby facilitating a more efficient conversion of organic waste into biogas.09-06-2012
20130065219Nutrient Monitoring and Feedback Control for Increased Bioproduct Production - The present invention pertains to methods of increasing the efficiency of producing a bioproduct. In some embodiments, the method increases the quantity of a bioproduct produced, or decreases bioproduct production time, in a bioreactor cell culture producing the bioproduct, the method comprising, (a) intermittently or continuously analyzing the concentration of one or more nutrients in the bioreactor cell culture; and (b) adding to the bioreactor cell culture additional nutrient media when the concentration of the one or more nutrients is lower than a target value.03-14-2013
20110281255BIOLOGICAL PROCESS FOR CONVERTING ORGANIC BY-PRODUCTS OR WASTES INTO RENEWABLE ENERGY AND USABLE PRODUCTS - Apparatus for the treatment of organic waste streams is disclosed, in which the organic waste stream is treated in order to reduce the average particle size prior to entry into a biological reactor. The use of a mechanical device to reduce this average particle size while simultaneously mixing the organic waste stream increases the efficiency of the biological reactor. The mechanical device is preferably one which causes attrition and reduction in the average particle size of the organic waste stream. This results in a lower viscosity feed to the biological reactor, and therefore a far more efficient process, which can therefore handle a feed stream of greater concentration than was previously thought to be possible.11-17-2011
20110281254METHOD AND APPARATUS FOR ANAEROBIC DIGESTION FOR CROP STALK - This disclosure discloses a process and an anaerobic digestion system for crop stalk/straw. The process in one example comprises (A) Feeding, (B) Heating and Digestion at the set temperature, (C) Discharging of Biogas, Sludge and Effluen{grave over ( )}t. The system in one example comprises (I) High Solid Content Digester (II) Hydro-Circulation Digester and (III) Stalk/Straw Feeder. Steps (A), (B) and (C) are accomplished in the devices (I) and (II). The step (A) is accomplished through the stalk/straw feeder (III), a special feeding mechanism, by which the crushed or smashed stalk/straw is pushed into the bottom of digester vessel. After being fermented or digested in the device (I), feedstock that is the mixture of biomass and water flows freely into the device (II) through the feedstock discharge outlet. The stalk feeder (III) is comprised of a hopper (11-17-2011
20080286749ENHANCED PROTEIN EXPRESSION USING AUTO-INDUCTION MEDIA - Methods for refining the compositions of bacterial growth media to improve heterologous expression of desired recombinant target genes are provided. Also provided are compositions and culture media obtained using the above methods.11-20-2008
20090215022EXTRA-CAPILLARY FLUID CYCLING SYSTEM AND METHOD FOR A CELL CULTURE DEVICE - An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.08-27-2009
20130022959Process for controlling and monitoring the production of biogas - The present invention relates to a process for online and direct control of production of biogas in an anaerobic digester comprising the steps of: 01-24-2013
20130022958In Situ Detoxification of Fermentation Inhibitors with Reducing Agents - The present invention provides a method for decreasing the fermentation inhibition in a fermentation of cellulose-derived material in a fermentor, wherein fermentation inhibitory properties of the material subjected to fermentation is decreased by an addition of at least one reducing agent to the fermentor. Further, there is provided a method of increasing the fermentability of a fermentation process comprising the steps of measuring the fermentability of the fermentation process and if the fermentability is below a reference value, then adding at least one reducing agent to the fermentation process.01-24-2013
20130022957ENHANCED ANIMAL CELL GROWTH USING ULTRASOUND - A method of increasing animal cell growth and monoclonal antibody production in an animal cell or cell culture includes the use of ultrasound at a frequency greater than about 1 MHz.01-24-2013
20130022956ANALYZER, AND METHOD FOR PERFORMING A MEASUREMENT ON A SAMPLE - An analyzer includes a display, measurement hardware configured to perform a measurement on a sample, and a controller. The controller is in communication with the display and the measurement hardware and is configured to communicate, via the display, a first pre-analytical procedure of the sample prior to measurement of the sample. The controller is also configured to maintain the analyzer in a state associated with the first procedure for an amount of time equal to a time needed for performing the first procedure. After the time needed for performing the first procedure has elapsed, the controller is configured to communicate, via the display, a second pre-analytical procedure of the sample prior to measurement of the sample.01-24-2013
20110287405BIOMASS PRODUCTION - There is provided a process of growing a phototrophic biomass in a reaction zone. The reaction zone comprises a production purpose reaction mixture that is operative for effecting photosynthesis upon exposure to photosynthetically active light radiation. The production purpose reaction mixture comprises production purpose phototrophic biomass that is operative for growth within the reaction zone, such that a reaction zone concentration of production purpose phototrophic biomass is provided in the reaction zone. The growth of the production purpose phototrophic biomass comprises that which is effected by the photosynthesis.11-24-2011
20120190005METHOD FOR A RATIONAL CELL CULTURING PROCESS - Biopharmaceutical process development with recombinant protein producing mammalian cells has realized a tremendous increase in both productivity and product yields in the past years. These achievements can be mainly attributed to the advancements in cell line development, media, and process optimization. Only recently, genome-scale technologies enable a system-level analysis to elucidate the complex biomolecular basis of protein production in mammalian cells promising an increased process understanding and the deduction of knowledge-based approaches for further process optimization. The present invention describes a method for a rational cell culturing process using such a knowledge-based approach.07-26-2012
20110217691OXYGEN-ASSISTED FERMENTATION PROCESS - A fermentation process uses substantially pure oxygen. The oxygen is the only reactive gas which is injected into a fermentation vessel. The oxygen is moved through the vessel solely by its own pressure. The process can be used with both mechanically-agitated and air-lifted fermenters. The mechanically-agitated fermenter includes an analyzer for measuring oxygen concentration in the exhaust line, and adjusting the flow of fresh oxygen into the vessel accordingly. In the air-lifted fermenter, an analyzer measures the oxygen concentration in the head space of the vessel, and operates valves which either recycle the gas from the head space, or vent that gas to the outside, according to the measured concentration. A stream of nitrogen is periodically injected into the vessel to drive out carbon dioxide and other gases, to control the pH of the fermentation medium. The present invention substantially improves the efficiency of a commercial fermentation process.09-08-2011
20110262891Microinjection apparatus and microinjection method - A microinjection apparatus is designed to introduce the transfecting material into the transductant by inserting a minute injection needle (10-27-2011
20120034595Enriched stem cell and progenitor cell populations, and methods of producing and using such populations - The present invention provides a novel method to isolate and expand pure progenitor/stem cells from a primary tissue explant, which produces a population enriched in multipotent functional progenitor/stem cells free of contaminating fibroblasts and other cell types. Cardiac progenitor/stem cells isolated by this method maintain their self-renewal and clonogenic character in vitro and differentiate into normal cells in myocardium, including cardiomyocytes, endothelial cells, and smooth muscle cells, after transplantation into ischemic hearts. The present invention also includes substantially pure populations of multipotent progenitor/stem cells, e.g., cardiac progenitor/stem cells, and their use to treat and prevent diseases and injuries, including those resulting from myocardial infarction.02-09-2012
20110217692Photobioreactors, Solar Energy Gathering Systems, And Thermal Control Methods - The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a prototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a photobioreactor.09-08-2011
20100081122SYSTEM AND METHOD FOR CULTIVATING CELLS - A state of cells while being cultivated is ascertained and a feed medium suitable for the cell state is added for producing a target substance to be produced with a high yield. The system for cultivating cells of the invention includes a bioreactor/fermentor for cultivating cells to be cultivated, a measuring device for measuring the culture cells being cultivated in the bioreactor/fermentor or a component contained in the culture solution, and a control device for selecting a feed medium to be added to the bioreactor/fermentor from two or more feed media having different composition ratios based on the culture cells state determined by measured values obtained by the measuring device.04-01-2010
20120107793SAMPLE PROCESSING SYSTEM AND METHOD OF PROCESSING SAMPLE - A sample processing system comprising: a transporting device that transports a sample; a plurality of sample processing devices that are arranged along a transport path for the sample transported by the transporting device and configured to process the sample transported by the transporting device based on a processing order; a controller configured to receive a first processing order for the sample and control the transporting device to transport the sample based on the received first processing order, and configured to receive a second processing order for the sample additionally and control the transporting device to transport the sample based on the received second processing order; and a display, wherein the controller is configured to prompt the display to show progress information indicating a progress status of processing the sample with respect to each of the first and second processing orders. A method of processing sample in a sample processing system.05-03-2012
20120107792SYSTEMS AND METHODS FOR DELIVERY OF GASES TO ALGAL CULTURES - Photobioreactors according to embodiments of the present invention deliver nutrient gas intermittently to the photobioreactor media. In some embodiments, one or more gases are delivered according to a duty cycle or timing pattern. According to some embodiments, algae is grown in a photobioreactor using intermittent introduction of carbon dioxide. In other embodiments, carbon dioxide is supplied to algae grown in a photobioreactor in whole or in part from a head space above the media of the photobioreactor.05-03-2012
20090263782Reaction apparatus - An apparatus 10-22-2009
20090142745INSTRUMENTS AND METHODS FOR EXPOSING A RECEPTACLE TO MULTIPLE THERMAL ZONES - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.06-04-2009
20120295248SYSTEMS AND METHODS FOR DYNAMIC GAS CONTROL IN A DISPOSABLE VESSEL - A disposable mixing vessel incorporates a system for dynamic gas control. The disposable mixing vessel includes a first agitating element and a second agitating element located above the first agitating element. The system for dynamic gas control enables a cell culture process to occur in the disposable mixing vessel while maintaining certain parameters of the liquid medium to be within a desired range. Such parameters may include the level of dissolved carbon dioxide, the level of dissolved oxygen, the pH and the osmolality. The system for dynamic gas control may control gas inlet and outlet ports in the disposable mixing vessel for sweeping a suitable composition of gas across the headspace of the liquid medium.11-22-2012
20090104594Bioreactor Process Control System and Method - A bioreactor includes a sensor linked to a model free adaptive controller or optimizer. The sensor can provide a real time measurement of a quantity that correlates with final product titer or other desired product quality attribute.04-23-2009
20110207111METABOLIC RATE INDICATOR FOR CELLULAR POPULATIONS - Described and claimed is a novel system and method for monitoring the metabolic rate of a cellular population in an industrial process. The invention includes obtaining a sample of the cellular population and initiating a reaction between a metabolic component of the cellular population and a bioreporter. The reaction produces a detectable metabolic signal which is measured and analyzed to determine a metabolic rate of the cellular population. In preferred embodiments, a controller is operable to provide prompts to a user and/or automate various steps of the invention.08-25-2011
20090170061DEVICE COMPRISING A SAMPLE OF RECONSTRUCTED TISSUE AND A DETECTION SYSTEM - The present invention relates to a device (07-02-2009
20110269114YEAST GROWTH MAXIMIZATION WITH FEEDBACK FOR OPTIMAL CONTROL OF FILLED BATCH FERMENTATION IN A BIOFUEL MANUFACTURING FACILITY - The present invention provides novel techniques for controlling biofuel production processes. In particular, estimated yeast activity values are determined by yeast activity sensors. These estimated yeast activity values are used to bias predicted yeast activity values from an inferential dynamic predictive model. The biased predicted yeast activity values are in turn used to control a fermentation sub-process of the biofuel production process, while also be used to update the inferential dynamic predictive model, to maximize yeast activity in the fermentation sub-process. Maximizing yeast activity and yeast growth in the fermentation sub-process leads to the maximization of biofuel production in the biofuel production process.11-03-2011
20110207112AUTOMATED SYSTEM FOR CRYOPRESERVATION OF OOCYTES, EMBRYOS, OR BLASTOCYSTS - An automated system and method of cryopreservation and reanimation of oocytes, embryos, or blastocysts is disclosed. One or more oocytes or embryos are positioned in a processing container, the processing container being configured to allow fluid to flow into and out of the processing container, where two or more fluids flow into and out of the processing container with oocytes or embryos therein. The temperature of the fluid may be controlled in the processing container according to predetermined requirements. The flowing of the fluids may be controlled by a central controller adapted to control one or more valves.08-25-2011
20110223580SAMPLE ANALYZER AND SAMPLE TRANSPORTING METHOD - The present invention is a sample analyzer including: a first and a second measurement unit configured to measure a sample accommodated in a sample container; a rack transport unit configured to transport each of a plurality of sample containers held in a sample rack to either the first or the second measurement unit; and a controller configured to acquire a measurement item information indicating a measurement item of each of samples accommodated in the plurality of sample containers held in the sample rack, determine a sample container to be a transport object and a measurement unit to be a transport destination of the sample container based on the acquired plurality of measurement item information, and control the rack transport unit to transport the sample container determined as the transport object to the measurement unit determined as the transport destination.09-15-2011
20110223582CELL CULTURE DEVICE AND METHOD OF CULTURING CELLS - The present invention relates to a cell culture device (09-15-2011
20110229873FERMENTATION PROCESS USING SPECIFIC OXYGEN UPTAKE RATES AS A PROCESS CONTROL - Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.09-22-2011
20090220934METHODS AND PROCESSES OF CONTROLLING FERMENTATION - The present invention relates to methods and processes for controlling fermentation. Two proportional feedback control loops are implemented in a cascade. One control loop is used to maintain the pH by adjusting the dissolved oxygen-stat setpoint. The other control loop is used to maintain the dissolved oxygen by regulating the nutrient feed rate using the newly adjusted dissolved oxygen-set point.09-03-2009
20090117533Apparatus For Producing And Handling A Flowing Substance05-07-2009
20100240020Method of making biological components for devices by forced environmental adaptation - An improved method for the design and development of high performance biologically-derived components for use in hybrid devices. The biologically-derived component is used in hybrid constructs that may be nanostructures, given the small size of the biological parts. Force adaptation is used to bring an organism from which the biologically-derived component is developed to provide such a component meeting a desired measure of performance. In one specific embodiment, chlorosomes of 09-23-2010
20100240021METHOD AND APPARATUS FOR AUTOMATED STAINING OF BIOLOGICAL MATERIALS - Various embodiments of the present invention provide methods and systems for optimally staining biological samples for analysis. In one embodiment, images of a sample are recorded before and after the application of a staining reagent and a decolorization reagent. A difference image is then generated based at least in part on a comparison of the images of the sample recorded before and after the application of the staining and decolorization reagents. Application parameters of the staining and decolorization reagents are then corrected based at least in part on the difference image such that the reagents may be optimally reapplied to generate a final image of the sample that may enable a user to better differentiate at least one target of interest in the sample. In one example, embodiments of the present invention allow for the generation of images that show only Gram-positive bacteria or only Gram-negative bacteria.09-23-2010
20120034596DEVICE FOR AUTOMATICALLY CULTIVATING CELLS IN PARALLEL - A device for automatically cultivating cells in parallel in cell culture vessels, in particular microtiter (MT) plates (02-09-2012
20120196271Iris Control System for Conducting the Identification of Bacteria in Biological Samples - A system and a method for optimizing an iris setting, used in combination with a lamp, for each excitation wavelength for each carousel run in an apparatus for identifying and measuring bacteria in biological samples. The system includes a feedback control loop positioned between a filter wheel and an optical cup for measuring the intensity level of the excitation wavelength, and feeding this information to an iris having an iris setting control device such that the iris setting may be adjusted based upon the measured intensity level to control and optimize the level of light fed to the filter wheel from the lamp. The iris setting can be adjusted so that the level of light fed to the filter wheel remains constant during the lifetime of the lamp and to ensure that the level of light fed to the sample remains below the level at which photo-bleaching occurs.08-02-2012
20130130229Method for Detecting Nucleic Acid Amplification in Sample and Device Therefor - A device for detecting nucleic acid amplification in a sample, comprising: a loading unit (thermoregulation unit) which is provided with a plurality of holes for loading reaction containers and capable of arbitrarily controlling a measurement unit for measuring samples in the containers that are loaded in the holes. The loading unit and the measurement unit, which are placed opposite to each other, can be operated independently from each other. In a transfer operation, the operation speeds of the thermoregulation unit and measurement unit are controlled so that the sum of these speeds amounts to an arbitrary constant value.05-23-2013
20110129812METHOD AND APPARATUS FOR INJECTION OF CO2 OR STACK GASSES TO INCREASE ALGAL BIOMASS PRODUCTION - An algal production system that uses CO2 injections to promote the growth of algae. The system includes an algal growth medium within a floway for channeling water. A fluid diffuser also resides in the floway in proximity to the algal growth medium. The fluid diffuser injects CO2 into the water in the floway. The system further includes a detector for monitoring the pH levels of the water and a controller, which based on the measured pH levels, determines when and how much CO2 to inject into the water.06-02-2011
20110212433ALCOHOL PRODUCTION PROCESS - The invention relates to the production of products such as alcohols and acids by microbial fermentation, particularly microbial fermentation of substrates comprising CO. It more particularly relates to methods and systems for improving efficiency of production products by microbial fermentation. In particular embodiments, the invention provides a method of controlling substrate supply, such that production of desired metabolites is optimised.09-01-2011
20100021880Automated Macromolecule Sample Preparation System - An apparatus for preparing a macromolecule sample from a complex liquid mixture includes a hydraulic system adapted for control by an automated controller, comprising a pump and one or more valves. The hydraulic system can be controlled by an automated controller to apply the liquid mixture to one or more filters with a pressure differential across each filter. The filters include a rough filter selected to separate, from a macromolecule in a liquid mixture, at least a portion of one or more rough components in the mixture that are larger than the macromolecule. Further included is a fine filter selected to separate from the macromolecule at least a portion of one or more fine components in the mixture that are smaller than the macromolecule. A method for preparing a macromolecule sample includes automatically acquiring a liquid mixture, the mixture including a macromolecule. At least a portion of the other components in the mixture are automatically separated from the macromolecule by applying the mixture to each of one or more filters, with a pressure differential across each filter.01-28-2010
20110086337FLUID TRANSFER CONTROL FOR REAL-TIME PCR - The present invention provides a fluid transfer control method, the method based on measurements of intensities of dyes within the fluid to be transferred. In more detail, the present invention makes use of control dyes and quencher molecules for the fluid transfer controls.04-14-2011
20110244444METHODS OF MULTIPLYING PLANT EMBRYOGENIC TISSUE IN A BIOREACTOR - The present invention provides methods of multiplying plant embryogenic tissue in a bioreactor.10-06-2011
20090035745Site-Specific Dosing of Cellular Cultures - Systems and methods for site-specific dosing of cellular cultures are provided. Some of the systems provided comprise at least two laminar flow channels; and an ablatable membrane that is disposed between the at least two laminar flow channels. Other systems provided comprise at least two laminar flow channels; and an ablated membrane that is disposed between the at least two laminar flow channels. Some of the methods provided comprise providing at least two laminar flow channels; providing a membrane disposed between the at least two laminar flow channels, wherein the membrane is selected from the group consisting of an ablatable membrane and an ablated membrane; placing cells into at least one of the at least two laminar flow channels; providing a reagent medium; and flowing the reagent medium through at least one other of the at least two laminar flow channels.02-05-2009
20100055663METHOD FOR CONTROLLING A TISSUE PROCESSOR AND TISSUE PROCESSOR - A method for controlling a tissue processor and a tissue processor for processing tissue samples is described. A retort is provided comprising a cover that can be opened and closed by an operator. The retort cover is closed prior to tissue processing. The actuation state of a first and a second operating element can be determined. An operator is prompted to confirm unlocking of the closed retort cover by actuating a second operating element. The tissue processing is interrupted when an actuation of the second operating element is determined and the closed retort cover is unlocked and is continued after the retort cover is once again locked. After having completed tissue processing the retort cover is unlocked. By means of the described method and tissue processor improper intervention during ongoing tissue processing is prevented.03-04-2010
20110097701HCN Removal From Syngas Using Chemical and Biological Treatment - A method for the high removal of ammonia and HCN from syngas in a cost effective and environmentally benign and sustainable fashion, with the need for minimal chemical addition by using a combination of water based gas scrubbing, HCN scrubbing and biological processing steps.04-28-2011
20120135392ULTRASOUND STIMULATION DEVICES AND TECHNIQUES - Ultrasound stimulation devices and related techniques are disclosed. An ultrasound transducer for generating ultrasound energy is carried by a transducer housing that seals the transducer and may also include a positioning element for positioning the transducer proximate an application area to which generated ultrasound energy is to be applied. The transducer housing may also carry such components as a battery, a wireless receiver, and a controller. The same housing or a separate sensor housing may include an ultrasound sensor that provides feedback to the ultrasound transducer or its controller, illustratively through a wireless transmitter.05-31-2012
20110065084INTEGRATED OXYGEN MEASUREMENT AND CONTROL FOR STATIC CULTURE VESSELS - A system and method for measuring and controlling oxygen in a culture vessel utilizes a non-invasive oxygen sensor and an agitator. A controller controls the agitator based on feedback supplied by the oxygen sensor. The agitator is used to increase oxygen transport into the liquid phase thereby raising the level of oxygen in the culture medium. The agitator driven equilibration results in precise control of the culture medium oxygen.03-17-2011
20100304355DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEM - Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.12-02-2010
20100304356ASSEMBLY AND A METHOD FOR IN SITU PROCESSING OF WASTE - The invention relates to a device and a method for the in situ processing of waste, in particular for cleaning up a waste disposal site. The device comprises a sorting device with a set of processing devices connected downstream of said device. This set of processing devices comprises a fermenting device, a fluidized bed gasifier, and a pyrolysis device. Furthermore, the assembly comprises a control device for controlling and measuring the various material flows.12-02-2010
20120171659PARTICLE ANALYZER AND METHOD FOR ANALYZING PARTICLES - A particle analyzer may include a sampling unit configured to collect samples containing particles; a sample preparing unit configured to prepare different sub-samples; a reaction unit configured to incubate the sub-samples and one or more corresponding reagents respectively and provide them to the injecting unit; an injecting unit configured to inject the sub-samples to the optical unit; an optical unit configured to irradiate the sub-samples to obtain particle information; a processing unit configured to process and output the particle information; and a threshold value unit configured to compare a total number of particles with a pre-determined threshold value and to output a result of the comparison to the injecting unit to control subsequent injection of one or more sub-samples.07-05-2012
20110256523OPTICAL FLOW CYTOMETER AND METHOD OF INVESTIGATION - The present invention relates to a flow cytometer (10-20-2011
20110159475INTEGRATED BIO-REACTOR MONITOR AND CONTROL SYSTEM - Systems and methods for automatically controlling conditions of a process are disclosed. In one example, a controller is programmed with a sequence of steps and parameters required to carry out a bioreactor process. The controller receives information related to a condition of the process over a first communication network, determines a control signal based on the received information and the programmed process, and sends the control signal over a second communication network to a benchtop utility tower. In one example, the utility tower can include transmitters for temperature, pH, and dissolved oxygen that send information related to a condition of the process to the controller over the first communication network, and an agitation system, a gas control system, a temperature control system and a pump control system that perform a control action based on the control signal affecting the process condition. The utility tower can include a computer with a human-machine interface that communicates with the controller over a third communication network.06-30-2011
20110177489SPECIMEN IDENTIFICATION AND DISPENSATION DEVICE AND SPECIMEN IDENTIFICATION AND DISPENSATION METHOD - A specimen identification and dispensation device includes an optical measurement device which is an identification part for measuring and identifying optical information on a specimen by emitting exciting light to the specimen being a measurement target dispersed in a liquid flowing through inside of a capillary, a dispensation part for dispensing the identified specimen into wells being sections to be dispensed through a nozzle, and a concentration adjustment part which adjusts the number of the specimens contained in an aliquot solution to a desired number according to the concentration of a sample liquid and the amount of the aliquot solution. The dispensation part is movable three-dimensionally with respect to the identification part and the nozzle.07-21-2011
20080227081PROCESS FOR DECOMPOSING HYDROGEN SULFIDE BY MEANS OF FEEDING OXYGEN - A process is provided for decomposing hydrogen sulfide in a biogas fermenter (09-18-2008
20120122074MAIL SCREENING TO DETECT MAIL CONTAMINATED WITH BIOLOGICAL HARMFUL SUBSTANCES - A multi-tier approach for use in a mailroom for detecting bio-threats conveyed by mail. In a first tier procedure, mail entering the mailroom is continuously automatically screened at a mail screening station to detect a potential bio-threat contamination. If a potential bio-threat is detected, an alarm signal is generated, a sample of the potential bio-threat is collected, and a second tier procedure is initiated. The second tier procedure uses a manual test, such as a nucleic acid amplification and detection assay to detect any of a plurality of different specific bio-threats in the sample. If a specific bio-threat is found, appropriate steps are taken to limit spread of the bio-threat and exposure of personnel. A third tier procedure uses a manual assay to check for a specific toxin in background samples collected over a predefined time interval at each mail screening station and in the air handling system for the mailroom.05-17-2012
20120064507USE OF GAS VOID FRACTION MEASUREMENT IS THE CLOSED LOOP CONTROL OF A FERMENTATION PROCESS - A technique related to a fermentation process; where a signal processor receives a signal containing information about an amount of entrained air in a mixture forming part of a fermentation process in a tank; and determines a level of foam in the tank based at least partly on the amount of entrained air in the mixture. The signal processor may also provide a control signal for controlling an amount of defoamer (or antiforming agent) added to the mixture in the tank so as to control the production of foam within the tank by controlling the amount of defoamer added to the mixture in the tank.03-15-2012
20110189650MICROFLUIDIC CELL SORTER WITH ELECTROPORATION - A biological particle manipulating device and method of its use. The device includes structure arranged to urge biological particles into substantially single file travel through an interrogation zone. Operable alignment structure nonexclusively include sheathed fluid flow, capillary tubes, an orifice, and fluid microchannels. One or more detector, selected from a plurality of operable such structures, may be employed to sense the presence of a biologic particle in the interrogation zone. Certain exemplary detectors may operate on the Coulter principle, or may detect a Stokes' shift, or side-scatter radiation. Discrimination structure is generally provided to categorize particles as being in one or another sub-population of a mix of biological particles that may be carried in a fluid sample, such as by cell type, size, or the like. Particle manipulating structure is disposed to impose a change on substantially all particles in any selected sub-population while leaving unchanged substantially the remaining sub-population(s). The device may be operated to essentially purify (in a living or viable sense) a sample including biological particles that are carried in a fluid diluent. The device may also be operated to electroporate cells on either a discriminating, or nondiscriminating, basis.08-04-2011
20120308988MICROBIAL MONITORING AND PREDICTION - Aspects describe capturing various bacteria levels within a process affected by microbial agents. A model of the process and a model of expected bacteria growth are analyzed and, based on the analysis, at least one process parameter is automatically modified to improve or optimize the product or process or other business or operational objectives. Also provided are at least two autonomous agents within the process. The at least two autonomous agents communicate and autonomously implement an action in an upstream stage and/or downstream stage within the process, wherein the at least two autonomous agents access the representation of the process and the biological representation and/or bio-chemical representation to implement the action.12-06-2012
20090220935APPARATUS AND METHOD FOR DISSOLVED OXYGEN CONTROL IN PARALLEL INTEGRATED BIOREACTOR ARRAY - Parallel, integrated bioreactor. The bioreactor includes a plurality of growth chambers, each growth chamber associated with a peristaltic oxygenating mixer and separated therefrom by a porous membrane. Each oxygenating mixture has a gas inlet and a gas outlet with the gas inlet in fluid communication with a gas reservoir. A gas mixer switch is provided for controlling oxygen concentration in the reservoir. The apparatus and methods disclosed in the application allow precise control over dissolved oxygen concentration with a quick response time.09-03-2009
20080299539Parallel integrated bioreactor device and method - In one embodiment, the present invention introduces integrated fluid injection and mixing devices to enable pH control in a miniature parallel integrated bioreactor array system. In another embodiment, the environmental conditions of the growth chamber is enabled through fluidic injections in a miniature parallel cell culture system. In still another embodiment, the present invention utilizes gas switches to control oxygen concentration within a miniature parallel integrated bioreactor array.12-04-2008
20100255458BIOREACTOR - The invention provides devices and methods for the growth of photoautotrophic organisms. The devices and methods address issues related to the design of bioreactors, selection of a photoautotrophic organism, growth of the photoautotrophic organisms, extraction of biomass products, and/or use of the biomass products as a renewable energy source.10-07-2010
20110306031FLUIDIC SYSTEM FOR A FLOW CYTOMETER - The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.12-15-2011
20110306033BIOCHEMICAL PROCESSING APPARATUS - A biochemical processing apparatus is provided having a stage receiving a biochemical reaction cartridge which includes chambers and flow paths communicating therebetween, a moving system for moving liquid via the flow paths, and a detector for detecting the presence of the liquid in a chamber and/or the amount of the liquid. In addition, a determining device determines a result of the movement of the liquid from the information of the liquid in the chamber detected by the detector.12-15-2011
20120040331Noninvasive Bioreactor Monitoring - A pair or receptacles capable of housing an emitter probe and a detector probe are installed inside a bioreactor to monitor the properties of the nutrient media without contacting the nutrient media.02-16-2012
20120040330BIOLOGICAL AND CHEMICAL COLLECTION AND DETECTION - A fluorescence-cued Raman identification system comprises a collection subsystem to collect samples, a reagent treatment subsystem to treat collected samples and a fluorescence imaging subsystem that automatically takes at least one image of the collected sample. The subsystems further include a Raman spectroscopy subsystem that measures the spectrum of viable organisms located from at least one collected image, a visible imaging microscope subsystem that provides a visual image of the particle analyzed by the Raman spectroscopy subsystem and a processor configured to perform image processing to locate viable organisms within the sample, which are targeted by the Raman spectroscopy subsystem. The processor further analyzes the spectrum recorded by the Raman spectroscopy subsystem to make a preliminary identification of the targeted organisms, which can be verified by an operator using the visible imaging microscope subsystem.02-16-2012
20120040329Process For Continuous Production Of Bacteriophage - As bacteriophage use in industrial application grows there is a need for commercial quantities of identified bacteriophage. This invention discloses a continuous flow bacteriophage proliferation process that can provide commercial quantities of desired bacteriophage in concentrations suitable for industrial use. Host bacteria and virulent bacteriophage are fed into a reactor vessel where the phage attach to, infect and lyse the host bacteria providing multiple replications of it and coincidentally concentrating the phage.02-16-2012
20120040328FERMENTER FEED SYSTEM FOR FERMENTABLE BIOMASS OF A BIOGAS SYSTEM AND METHOD FOR OPERATING THE FEED SYSTEM - A fermenter feed system for fermentable biomass of a biogas system comprising at least one fermenter, and a delivery and treatment device located between a biomass depot and the fermenter. A mechanical cell breakdown apparatus (02-16-2012
20120149005REACTION TREATMENT DEVICE AND REACTION TREATMENT METHOD - Disclosed herein is a reaction treatment device including a temperature control section which includes a first temperature control section disposed at an outer peripheral edge part of a group of reaction regions and a planar second temperature control section, wherein the first temperature control section and the second temperature control section are disposed opposite to each other, with the reaction region group therebetween.06-14-2012
20100068693Nutrient Monitoring and Feedback Control for Increased Bioproduct Production - The present invention pertains to methods of increasing the efficiency of producing a bioproduct. In some embodiments, the method increases the quantity of a bioproduct produced, or decreases bioproduct production time, in a bioreactor cell culture producing the bioproduct, the method comprising, (a) intermittently or continuously analyzing the concentration of one or more nutrients in the bioreactor cell culture; and (b) adding to the bioreactor cell culture additional nutrient media when the concentration of the one or more nutrients is lower than a target value.03-18-2010
20120308989CONVERSION OF AQUATIC PLANTS TO LIQUID METHANE, AND ASSOCIATED SYSTEMS AND METHODS - Systems and methods for converting aquatic plants to liquid methane are disclosed. A representative system includes an aquatic plant cultivator, an anaerobic digester operatively coupled to the aquatic plant cultivator to receive aquatic plants and produce biogas, and a biogas converter coupled to the anaerobic digester to receive the biogas and produce liquefied methane and thermal energy, at least a portion of the thermal energy resulting from a methane liquefaction process. The system can further include a thermal path between the biogas converter and at least one of the aquatic plant cultivator and the anaerobic digester. A controller can be coupled to the biogas converter and the aquatic plant cultivator and/or the anaerobic digester. The controller can be programmed with instructions that, when executed (e.g., based on measured variables of the system), direct the portion of thermal energy between the biogas converter and the aquatic plant cultivator and/or anaerobic digester.12-06-2012
20120308990Rapid Thermocycler System for Rapid Amplification of Nucleic Acids and Related Methods - A thermocycling device and method of operating a thermocycler instrument, the instrument including a sample holder, at least one thermal cycling element, and at least one first and second temperature sensors, for causing the sample holder containing the at least one sample to undergo polymerase chain reaction amplification by repeated cycling between at least a denaturation heating stage and an annealing cooling stage. The first temperature corresponding with the temperature of the sample holder is monitored using the at least one first temperature sensor, and a second temperature corresponding with the temperature external of the sample holder is monitored using the at least one second temperature sensor. Based upon the first temperature and the second temperature, the power that is delivered to the at least one thermal cycling element of the instrument is dynamically controlled.12-06-2012
20120308991SUBSTRATE-SELECTIVE CO-FERMENTATION PROCESS - Biological method for conversion of a sugar-containing organic material into a desired biochemical product. Use of a plurality of substrate-selective cells allows different sugars in a complex mixture to be consumed concurrently and independently. The method can be readily extended to remove inhibitory compounds from hydrolysate.12-06-2012
20110318725CELL CULTURE METHOD, CELL CULTURE DEVICE, METHOD FOR COUNTING SUBSJECT MATTERS TO BE COUNTED IN CONTAINER AND DEVICE FOR COUNTING - Cell aggregate formation control and cell aggregate disintegration control are carried out with respect to cells in a culture container to increase cell proliferation efficiency. The number of the cells in the culture container is counted without disassembly of a culture system and irrespective of the density of the cells.12-29-2011
20120003623NONLINEAR MODEL PREDICTIVE CONTROL OF A BATCH REACTION SYSTEM - The present invention provides novel techniques for controlling batch reaction processes. In particular, a parametric hybrid model may be used to parameterize inputs and outputs of batch reaction processes. The parametric hybrid model may include an empirical model, a parameter model, and a dynamic model. Critical quality parameters, which are correlated with, but not the same as, end-of-batch quality values for the batch reaction processes may be monitored during cycles of the batch reaction processes. The quality parameters may be used to generate desired batch trajectories, which may be used to control the batch reaction processes during the cycles of the batch reaction processes.01-05-2012
20120009558METHOD AND APPARATUS FOR IDENTIFICATION OF BACTERIA - An automated system for identifying in a biological sample microorganisms and their antimicrobial susceptibility (AST). The system provided an automated platform for preparing, from a single biological sample, inoculates for both ID and AST. The system loads a plate for ID testing as samples are being prepared for AST testing. The system tracks the sample and the inoculates from the samples to link the test results to the sample and the patients from whom the sample was obtained.01-12-2012
20120009559AUTOMATED CELL CULTURE SYSTEM AND PROCESS - The present invention relates generally to the field of cell culture, which is a laboratory process used primarily for the growth, propagation, and production of cells for analysis and the production and harvesting of cell products. The present invention comprises functionalized and/or engineered hydrogel microcarriers that exhibit any or all of the following properties: controllable buoyancy, ferro- or paramagnetism, molecular or fabricated reporting elements, and optical clarity. The microcarriers are used in a bioreactor that employs external forces to control said microcarrier kinetic energy and translational or positional orientation in order to facilitate cell growth and/or cellular analysis. The bioreactor can be part of an automated system that employs any or all of the following; a microcarrier manufacturing method, a monitoring method, a cell culture method, and an analytical method. Either a single bioreactor or a plurality of bioreactors are used in the automated system to enable cell culture and analysis with a minimum of human intervention.01-12-2012
20090239209COMBINED INSTALLATION FOR THE PRODUCTION OF BIOGAS AND COMPOST, AND METHOD OF SWITCHING A FERMENTER IN A LIKE INSTALLATION BETWEEN BIOGAS PRODUCTION AND COMPOSTING - A combined installation is disclosed for the production of biogas and compost, including a dry fermentation fermenter for producing biogas in a batch mode, a biogas outlet, a purging gas inlet, a biogas line connected to the biogas outlet, a waste gas line, a waste gas chimney connected to the biogas outlet via a first biogas/waste gas line, a waste gas flare connected to the biogas outlet via a second biogas/waste gas line, a fresh air line connected to the purging gas inlet, a control means for connecting the biogas outlet to the biogas line or the biogas/waste gas chimney via the first biogas/waste gas line or the waste gas flare via the second biogas/waste gas line and for connecting the purging gas inlet to the waste gas line or the fresh air line, and a measurement means connected to the control means for detecting methane and carbon dioxide concentrations.09-24-2009
20120064508Operation and Control of V-Trough Photobioreactor Systems - Disclosed herein are photobioreactor systems for high productivity aquaculture or aquafarming for growing of algae or other organisms in an aquatic environment featuring aspects that favor improved growth rates by achieving control over the contents of the growth medium, including carbon source, nitrogen source, and essential trace elements necessary for growth.03-15-2012
20120058460SLUG CONTROL DURING THERMAL CYCLING - The present invention, in one aspect, provides methods and systems for controlling slugs using temperature dependent fluorescent dyes. In some embodiments, the present invention uses one or more techniques to enhance the visibility of slugs, enhance a system's ability to differentiate between slugs, and enhance a system's ability to identify the positions of slugs.03-08-2012
20120064506OPTIMIZED BIOGAS (BIOMETHANE) PRODUCTION FROM ANAEROBIC REACTORS - An improved process and apparatus for producing biogas having a high methane content from a feed or substrate. Feed material is injected into a reactor having anaerobic microorganisms to form a bulk liquid in the reactor. The oxidation-reduction potential, pH, and temperature of the bulk liquid and the methane, carbon dioxide, hydrogen sulfide, and flow of the biogas is monitored. The amount of the feed material (substrate) fed to the reactor is adjusted in response to the monitoring parameters of the bulk liquid and biogas. A biomass recycle is provided to the reactor, thus increasing the reactor biomass retention time, or solids retention time within the reactor.03-15-2012
20120156669Biomass Production - A process of growing a phototrophic biomass in a reaction zone, including a reaction mixture that is operative for effecting photosynthesis upon exposure to photosynthetically active light radiation, is provided. The reaction mixture includes phototrophic biomass that is operative for growth within the reaction zone. In one aspect, the carbon dioxide supply is modulated in response to detected process parameters. In another aspect, inputs to the reaction zone are modulated based on changes to the carbon dioxide supply. In another aspect, dilution of the carbon dioxide-comprising supply is effected. In another aspect, pressure of the carbon dioxide-comprising supply is increased. In another aspect, water is condensed from the carbon dioxide-comprising supply and recovered for re-use. In another aspect, the produced phototrophic biomass is harvested at a rate which approximates a predetermined mass growth rate of the phototrophic biomass.06-21-2012
20120070818Flow Measurement and Control for Improved Quantification of Particles in Flow Cytometry - The present invention relates to methods that enable improved accuracy for quantitative particle counting in a flowing liquid stream. The methods of the present invention utilize the real-time measurement of flow rates and flow rate control through feedback mechanisms to improve quantification, and this improved quantification translates to more accurate particle counting. In certain embodiments, particles being counted are biological particles in a liquid sample, such as viruses.03-22-2012
20090023131CIRCUIT ARRANGEMENT FOR INJECTING NUCLEIC ACIDS AND OTHER BIOLOGICALLY ACTIVE MOLECULES INTO THE NUCLEUS OF HIGHER EUCARYONTIC CELLS USING ELECTRICAL CURRENT - The invention relates to a novel circuit arrangement for electrotransfection or electrofusion, which enables the transportation of DNA and/or other biologically active molecules to the nucleus of higher eukaryotic cells or the fusion of cells, independent of cell division and with reduced cell mortality.01-22-2009
20120264107REAL TIME MONITORING OF MICROBIAL ENZYMATIC PATHWAYS - This invention provides compositions and methods for monitoring and regulating the production of a target product of a biochemical pathway in an organism, such as butanol. A gene encoding a light-emitting reporter molecule, such as luciferase, is operatively linked with a transcription regulatory nucleotide sequence that regulates transcription of an enzyme in the pathway that signals the rate of production of the target product, such as butanol dehydrogenase. When a microorganism is transfected with such a reporter construct and cultured, the reporter is expressed contemporaneously with the enzyme. The amount of light produced by the reporter indicates amount of enzyme being produced which, in turn, signals the amount of target product being produced. When the reporter is measured in real time, it provides information that can be used to regulate culture conditions and to optimize production of the target product.10-18-2012
20120122075SYSTEM AND METHOD FOR DETECTING THREATENING AGENTS IN THE AIR - A multi-tier approach for use in a detecting harmful agents conveyed by the air. In a first tier procedure, the air (in a structure or a predefined area) is continuously automatically screened at a plurality of different predefined locations by air sensors distributed in the area to be monitored. Each air sensor is configured to detect a potentially harmful substance that is carried by the air proximate the predefined location, to determine if a potentially harmful substance might be present, but need not identify a specific harmful substance. When a potentially harmful agent is identified by an air sensor in the first tier screening, a sample of the potential threat is collected, and a second tier procedure is initiated. The second tier procedure uses a manual test, such as a nucleic acid amplification and detection assay to detect any of a plurality of different specific threats in the sample.05-17-2012
20100248208REAGENT PREPARING DEVICE, REAGENT PREPARING METHOD, AND SPECIMEN PROCESSING SYSTEM - A reagent preparing device capable of supplying a predetermined reagent, which includes a first liquid and a second liquid different from the first liquid, to a measurement section for measuring a specimen using the reagent, comprising: a pressure generator for generating pressure to transfer liquid; a reagent preparing section for executing a preparation operation of the predetermined reagent using the pressure generated by the pressure generator; and a controller configured for performing operations comprising: determining whether or not the reagent preparing section is executing the preparation operation, and controlling the generation of the pressure by the pressure generator according to the determination result, is disclosed. A reagent preparing method and a specimen processing system are also disclosed.09-30-2010
20130171616PIVOTING PRESSURIZED SINGLE-USE BIOREACTOR - Pressurized hermetically sealed bags disposed inside a cylindrical support and containing a septum with variable density of porosity and dividing the bag into two chambers are used to provide optimal mixing and gasification of nutrient media to grow a variety of biological cultures, particularly the cell cultures to produce a multitude of pharmaceutical and biotechnology products in a disposable system.07-04-2013
20120164623Laminar Flow Reactor - The present invention describes a laminar flow bioreactor with improved laminar flow lines of fluids. The bioreactor housing defines a chamber adapted to receive a scaffold. An inlet aperture at one end of the chamber is in fluid communication with an outlet aperture at the opposite end of the chamber. A bypass mechanism selectively operable from an open position to a closed position consisting of an iris assembly directs a portion of fluid flowing through the chamber around the scaffold-receiving area. This bioreactor is inserted in a bioreactor system.06-28-2012
20110183312MICROFLUIDIC CHIP FOR ACCURATELY CONTROLLABLE CELL CULTURE - A device is disclosed for culturing cells in at least one cell culture well. The device includes one or more interconnecting layers having a pattern therein, the pattern including at least one microfluidic channel, at least one cell culture well having an opening at one end and a side wall, the at least one microfluidic channel in fluid communication with the side wall of the at least one cell culture well, and having a maximum channel width substantially less than a maximum width of the at least one cell culture well. The device includes at least one of a controllable valve and a controllable pump in fluid communication with the microfluidic channel, the valve and pump being configured to selectably restrict fluid transport through the microfluidic channel. In some embodiments, the device includes a removable top layer adapted to cover each of the at least one cell culture well.07-28-2011
20120214150STIRRING METHOD, CELL CULTURE METHOD, STIRRING APPARATUS, AND CELL CULTURE APPARATUS - A stirring method includes measuring, with respect to cells which adhere to an inner surface of a culture vessel to be cultured, an ease of peeling between the culture vessel and the cell and an ease of peeling between the mutual cells, and performing a stirring process on the cells in the culture vessel by determining a process content of the stirring process with respect to the cells in the culture vessel, based on the ease of peeling between the culture vessel and the cell and the ease of peeling between the mutual cells.08-23-2012
20120077183Reaction apparatus - An apparatus 03-29-2012
20120315620Method and Apparatus for Discriminating Undifferentiated Pluripotent Stem Cells, and Automated Culture Method and System - Provided are a method capable of discriminating between a colony of differentiated pluripotent stem cells and a colony of undifferentiated pluripotent stem cells, and a method for automatically culturing undifferentiated pluripotent stem cells and a system thereof.12-13-2012
20120178077THERMAL CALIBRATION - The present invention relates to the use of one or more amplicons as temperature calibrators. In some embodiments, the calibrators may be used to calibrate the temperature of a microfluidic channel in which amplification and/or melt analysis is performed. In some embodiments, the amplicons may be genomic, ultra conserved elements and/or synthetic. The amplicon(s) may have a known or expected melt temperature(s). The calibrators may be added to primers of study or may follow or lead the primers of study in the channel. The amplicon(s) may be amplified and melted, and the temperature(s) at which the amplicon(s) melted may be determined. The measured temperature(s) may be compared to the known temperature(s) at which the amplicon(s) was expected to melt. The difference(s) between the measured and expected temperatures may be used to calibrate/adjust one or more temperature control elements used to control and/or detect the temperature of the channel.07-12-2012
20100009335TEMPERATURE-REGULATED CULTURE PLATES - Described herein are environmentally isolated tissue culture devices that may be used for cell culture, as well as systems including these devices and methods for using them. These devices may include control features for regulating the micro-environment within a well or wells of the device. For example, on-board features may regulate the temperature, humidity, pH, media level, media composition, CO01-14-2010
20100009336System and method for bacterial vaginosis testing - A method and system for testing fluids from a patient is provided. In one embodiment, a portable device is configured with one or more testing modules adapted perform one or more tests on a fluid sample in order to determine if a patient has bacterial vaginosis. A timer module coupled to a sample transport is configured to move a vaginal fluid sample between one or more testing modules at various stages along a predetermined testing path. In an embodiment, the timer module is configured to move the vaginal fluid sample between the testing modules along a circular testing path. The vaginal fluid sample may be processed in sequential order over predetermined time periods with respect to the processing performed by the testing module in order to detect the presence of, or lack of, 01-14-2010
20090023132Hydraulic device for a blood analysis apparatus, associated method and analysis apparatus equipped with such a device - Hydraulic device for a blood analysis apparatus includes elements 01-22-2009
20120258440METHOD OF DECIDING DETACHMENT TIME FOR CELL, METHOD OF SUBCULTURING CELL AND APPARATUS FOR SUBCULTURING CELL USING THE SAME - A method of deciding detachment time of cells, and a method and apparatus for subculturing the cells using the method. The method of deciding detachment time of the cells from a culturing vessel using a separation enzyme in subculturing the cells includes: a photographing step of photographing an image of the cells treated with the enzyme; a computing step of calculating a contrast value of the photographed image, and computing a change rate of the contrast value; a comparison step of repeating the photographing step and the computing step until an increasing change rate of the contrast value is reduced to a predetermined change rate or less; and a reporting step of reporting a time to remove the enzyme from the cells and to detach the cells from the culturing vessel when the increasing change rate of the contrast value is reduced to the predetermined change rate or less.10-11-2012
20110123975DEVICE FOR AUTOMATICALLY ADJUSTING THE BACTERIAL INOCULUM LEVEL OF A SAMPLE - Various embodiments of the present invention provide, for example, a system and method for automatically adjusting the inoculum level of a sample. Certain embodiments of the present invention may measure a concentration of particles present in a preliminary sample using a sensor device and determine an amount of diluent to be added to or removed from a sample container to prepare a sample having a selected concentration of particles, corresponding to a selected inoculum level. Embodiments of the present invention may also automatically add or remove the diluent using an automated fluidics system so as to prepare a sample having the selected particle concentration. Once the selected particle concentration is achieved and verified, some embodiments may also remove at least a portion of the sample from the sample container such that the container contains a selected volume of the sample.05-26-2011
20090075248Particle sensor with wide linear range - This invention provides a novel methods and devices for measurement of particle concentration or changes in particle concentration over a wide linear range. The invention comprises one or more radiation sources and one or more detectors contained in a housing which is interfaced to a medium containing particulate matter. The one or more radiation sources are directed into the medium, scattered or transmitted by the particulate matter, and then some portion of the radiation is detected by the one or more detectors. Methods for confining the measurement to a specific volume within the medium are described. Algorithms are provided for combining the signals generated by multiple source-detector pairs in a manner that results in a wide linear range of response to changes in particle concentration. In one embodiment the sensor provides non-invasive measurements of biomass in a bioreactor. In another embodiment an immersible probe design is described, which may be suited for one-time use. In an addition embodiment, a sensor is provided which is well suited to the rapid sequential measurement of particle concentration in multiple vessels, such as assessment of biomass in series of shake flasks.03-19-2009
20120322047Apparatus And Method For Cell Exploitation - The present invention relates to an apparatus (12-20-2012
20110229872Microfabricated Cell Sorter - The invention provides a microfabricated device for sorting cells based on a desired characteristic, for example, reporter-labeled cells can be sorted by the presence or level of reporter on the cells. The device includes a chip having a substrate into which is microfabricated at least one analysis unit. Each analysis unit includes a main channel, having a sample inlet channel, typically at one end, and a detection region along a portion of its length. Adjacent and downstream from the detection region, the main channel has a discrimination region or branch point leading to at least two branch channels. The analysis unit may further include additional inlet channels, detection points, branch points, and branch channels as desired. A stream containing cells is passed through the detection region, such that on average one cell occupies the detection region at a given time. The cells can be sorted into an appropriate branch channel based on the presence or amount of a detectable signal such as an optical signal, with or without stimulation, such as exposure to light in order to promote fluorescence.09-22-2011
20110250582METHODS AND SYSTEMS FOR GAS PRODUCTION FROM A RESERVOIR - A method and system for production of biogenerated gas from a zone in a reservoir are described. Microbial conversion of petroleum in the zone to biogenerated gas is stimulated. The biogenerated gas can be, for example, methane, hydrogen or carbon dioxide, or another gas. Gas including the biogenerated gas is produced from the zone to surface. While producing the gas, production parameters are monitored including reservoir pressure and an isotopic composition of the produced gas. Based on the monitored production parameters, at least one of stimulation of the microbial conversion to control the composition of the produced gas or gas saturation in the zone to control mobility of the biogenerated methane is adjusted.10-13-2011
20120088224Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System with Control Conditions - Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.04-12-2012
20110306032DEVICE AND METHOD FOR DIAGNOSTIC ANALYSES - An integrated device for diagnostic analyses used to verify the presence of bacteria in at least a biological sample mixed with a eugonic culture medium in liquid form, to classify at least the type of bacteria, and to test a series of antibiotics, selected from a group of characteristic antibiotics at least for the type of bacteria identified, identifying those effective to determine the antibiotic therapy. The device comprises, inside an integrated structure, first containing means provided with containing elements in which the biological samples to be analyzed are distributed, second containing means comprising recipients or micro-plates thermostated with wells containing a eugonic culture medium in liquid form in which a first fraction of the biological samples to be analyzed is dispensed, and a first recipient and second recipients or plates with a relative first well and second wells in which a further fraction of the biological samples which resulted positive to the analysis is dispensed.12-15-2011
20120100525ULTRASOUND ENHANCED GROWTH OF MICROORGANISMS - A method of increasing the rate of growth, useful product production, or protein expression of a microorganism includes the step of exposing the microorganism to ultrasound having a frequency greater than about 1 MHz.04-26-2012
20130171617DEVICE AND METHOD FOR THE AUTOMATED ISOLATION AND TRANSFER OF AT LEAST ONE MICROSCOPIC SAMPLE FROM A SAMPLE CARRIER TO A COLLECTING SYSTEM - A device for the automated isolation and transfer of at least one microscopic sample from a sample carrier to a collecting system for subsequent automatic analysis is provided. The device comprises a selection unit for selecting at least one sample located on the sample carrier, a controllable isolation unit for the automated isolation of the at least one selected sample, a controllable transfer unit, which has carrier means for the defined receiving and deposition of the at least one selected isolated sample, for an automated and defined transfer of the at least one selected isolated sample from the sample carrier to the collecting system, and a control unit, which has a data link to the selection unit, the isolation unit and the transfer unit, for an automated isolation and transfer operation.07-04-2013
20130130227Infectious Disease Detection System - A method and apparatus for managing a zone. Information is obtained about an environment in the zone with a sensor system. A determination is made by an analyzer system as to whether a contagious condition is present in the zone using the information from the sensor system. An action is performed by a management system in response to the contagious condition being present.05-23-2013
20130130228METHOD AND DEVICE FOR IDENTIFYING MULTIPOTENT STEM CELL COLONY, AND METHOD AND DEVICE FOR AUTOMATICALLY CULTURING MULTIPOTENT STEM CELLS - A method and device achieves identification on whether a colony on a cultivation container is differentiated or undifferentiated on an occasion of cultivation of multipotent stem cell, and a method and device achieves a rapid culture of undifferentiated multipotent stem cells. Undifferentiated colony containing only undifferentiated multipotent stem cells is identified from other types of colonies by means of the circularity C of the colony in an image-processed taken image of the inside of cultivation container of a multipotent stem cell. More specifically, when a first threshold of the circularity of the colony is C05-23-2013
20130143200METHOD FOR AUTOMATED SPERM MANIPULATION AND DEVICE FOR HOLDING SPERM AND OOCYTES - The present invention relates to systems and methods for automated, computer-controlled, tracking and manipulation of motile specimen. The systems and methods of the present invention are suited for tracking and manipulating sperm, particularly for Intracytoplasmic Sperm Injection (ICSI) procedures. The present invention also relates also to devices for holding motile cells, such as sperm, and non-motile cells, such as oocytes. The device of the present invention comprises a sealed chamber having an air outlet, one well for the motile cells, and another well for non-motile cells.06-06-2013
20130143199SYSTEM AND METHOD INCLUDING ANALYTICAL UNITS - Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.06-06-2013
20130095469APPARATUS AND METHOD FOR DISPENSING CELLS OR PARTICLES CONFINED IN A FREE FLYING DROPLET - An apparatus for dispensing one or more cells or particles confined in a free flying droplet has a droplet generating device configured to eject out of an orifice a free flying droplet of a suspension of cells or particles. The droplet generating device has a branch-less one-way channel having the orifice at one end thereof. A device for detecting information on cells or particles located in an observation volume of the suspension within the branch-less one-way channel is provided. An ejected droplet is directed to a first position or a second position depending on the detected information.04-18-2013
20130115588INTEGRATED BIOREACTOR AND SEPARATION SYSTEM AND METHODS OF USE THEROF - The present invention relates to methods and systems for culturing and purifying target substance(s), such as selected proteins, viruses, pathogenic bacteria, antibodies, antigens, clotting factors, glycoproteins, and hormones, from source liquids wherein the culturing and purification is effected in an integrated system including a bioreactor and at least one separation unit that functions under the control of a single operating system and provides for disposable components.05-09-2013
20130095468Method and Apparatus for Producing Ammonia and Nitrogen Fertilizer Using Nitrogen Fixing Bacteria - The apparatus of the present invention includes a first nitrogen fixation tank open to the ambient air and nitrogen-fixing bacteria and a growth medium within the first nitrogen fixation tank downstream from the first nitrogen fixation tank for producing ammonium hydroxide from a combination of ambient air, water, and selected nutrients. The apparatus also includes a second evaporation tank to vaporize the ammonium hydroxide to form anhydrous ammonia.04-18-2013
20110217690Interconnected Bioreactors - A method of combining the content of bioreactors allowing homogeneous mixing in accordance with CFR21 is described that allows processing of variable size batches using a single validated bioreactor is described.09-08-2011
20110223583DEVICES AND METHODS FOR PROVIDING CONCENTRATED BIOMOLECULE CONDENSATES TO BIOSENSING DEVICES - Condensing devices and methods for providing a concentrated biomolecule condensate to one or more biosensing devices are provided. The concentrated biomolecule condensate is obtained from a fluid sample which potentially contains traces of one or more target biomolecules. The fluid sample is first separated into a filtered liquid and a retentate biomolecule condensate. A novel filtering module is provided for this purpose. The target biomolecules in the retentate biomolecule condensate are further separated from unwanted materials using magnetic beads coated with antibodies of the target biomolecules. The beaded biomolecule condensate obtained thereby is processed to extract constituents of the target biomolecules, thereby obtaining the concentrated biomolecule condensate, which is distributed to a biosensing device.09-15-2011
20110223581ELECTRONICALLY CONTROLLED DIAPHRAGM PUMP - An electronically controlled diaphragm pump system is provided. The pump systems comprises a pump housing with a drive gas chamber and a fluid chamber separated by a diaphragm. The drive gas chamber is connected to one or more gas ports for injecting and/or sucking a gas into and out of the gas chamber. The fluid chamber is connected to a least one port for fluid inlet and at least one port for fluid outlet, where the inlet port has a valve adapted to open for fluid inlet when gas is sucked out of the gas chamber and the outlet port has a valve adapted to open for fluid outlet when gas is injected into the gas chamber. The pump system further has gas pressure means connected to a gas inlet port for providing a drive gas pressure in response to a control signal, and gas under-pressure means connected to a gas outlet port for providing a gas under-pressure or sucking of gas in response to a control signal. Furthermore, the pump system has a displacement sensor for detecting displacement or position of the diaphragm, and control circuitry connected to the displacement sensor for determining the displacement or position of the diaphragm and adapted for supplying the control signals to the gas pressure means and the gas under-pressure means. It is preferred that the means for providing a drive gas pressure comprises a gas-pressure proportional control valve being connected to the gas port and the control circuitry, whereby the drive gas pressure is varied as a function of the control signal supplied by the control circuitry. Also the means for providing a gas under-pressure may comprise a gas-under proportional control valve for controlling the gas under-pressure as a function of the control signal supplied by the control circuitry.09-15-2011
20130149693MANAGEMENT OF ETHANOL CONCENTRATION DURING SYNGAS FERMENTATION - A process is provided for management of ethanol concentration during syngas fermentation. A process for fermentation of syngas includes inoculating a medium to provide an inoculated medium. Inoculated medium is contacted with syngas and cells and medium are removed and separated to provide concentrated cells and permeate. Ethanol is separated from the permeate to provide ethanol and a reduced ethanol aqueous stream. The reduced ethanol aqueous stream is returned to the fermentation.06-13-2013
20110275056Method and Apparatus for Controlling a Cell Expansion Apparatus - A method for controlling cell expansion comprising conducting a fluid containing cellular matter into a cellular growth area; providing oxygenated fluid to said cellular growth area to maintain conditions conducive for cell growth in said cellular growth area; monitoring inflow and outflow conditions; determining rates of change (first derivative) for selected conditions and calculating cell numbers therefrom; determining a rate of change of a rate of change (second derivative) for the selected conditions and calculating a predicted process time; and terminating the growth process when adequate cell numbers have been produced and an apparatus for performing the method.11-10-2011
20110275055THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL - A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.11-10-2011
20110275054ENHANCED ANIMAL CELL GROWTH USING ULTRASOUND - A method of increasing the rate of growth of an animal cell or cell culture include the use of ultrasound at a frequency greater than about 1 MHz.11-10-2011
20110275053ALCOHOL PRODUCTION PROCESS - The invention relates to the production of products such as alcohols and acids by microbial fermentation, particularly microbial fermentation of substrates comprising CO. It more particularly relates to methods and systems for improving efficiency of products by microbial fermentation. In particular embodiments, the invention provides a method of optimising production of desired products including the step of ascertaining the proportion of CO converted to CO2.11-10-2011
20120258441METHOD FOR CONTROLLING CULTURE PARAMETERS IN A BIOREACTOR - A method for controlling at least one culture parameter in a bioreactor bag (10-11-2012
20130189671Cell Culture System and Method of Use Thereof - The present invention is based in part on the discovery of significant improvements to cell culture systems and methods in terms of utility and range of application. The system allows for culture of cells in one or more defined spaces within a culture chamber defined by one or more spaced opposing surfaces to provide significant advantages over previously described culture methods. The system includes a chamber for receiving a fluid culture medium; a first surface and one or more second surfaces defining one or more spaces in the chamber; and one or more cells constrained within the one or more spaces. The second surface includes at least one opening for passage of a substance into the culture space.07-25-2013
20120021401DISPOSABLE CARTRIDGE FOR AUTOMATIC AND CONTINUOUS WATER QUALITY MONITORING - A disposable cartridge for use in assaying an analyte in an automated water quality monitoring analyzer comprising: (a) a platform; (b) array of containers for separately containing at least one reagent, a buffer and a so freeze dried preparation of luminescent bacteria, said containers being mounted on said platform; (c) reaction chamber mounted on said platform and configured for being moved between said containers, such that said reagent, said buffer and said freeze dried preparation of luminescent bacteria are conveyed to said reaction chamber in a predetermined sequence such that light detectable by said analyzer is emitted; (d) fluid transferring means for fluid transfer and mixing between said containers, reaction chamber, and analyzer; (e) conveying means for moving said cartridge to predetermined positions within said automated water quality monitoring analyzer for enabling analysis of said analyte.01-26-2012
20120028240ANIMAL CELL COLONY PICKING APPARATUS AND METHOD - Animal cell colonies are picked up automatically by an apparatus having a picking head with a plurality of hollow pins and an integrated imager for capturing an image of adherent or non-adherent animal cell colonies held in liquid or semi-solid medium. Image processing identifies the locations of the animal cell colonies to be picked. Picking an animal cell colony is performed by aligning each of the hollow pins in turn with a target animal cell colony location, introducing the hollow pin into the medium, and aspirating the animal cell colony into the hollow pin. In the case of an adherent colony, the distal end of the pin is forced into oscillation to detach the animal cell colony prior to aspiration. The animal cell colony is dispensed into a well plate by increasing pressure in the fluid conduit.02-02-2012
20120028239ANIMAL CELL COLONY PICKING APPARATUS AND METHOD - Animal cell colonies are picked up automatically by an apparatus having a picking head with a plurality of hollow pins and an integrated imager for capturing an image of adherent or non-adherent animal cell colonies held in liquid or semi-solid medium. Image processing identifies the locations of the animal cell colonies to be picked. Picking an animal cell colony is performed by aligning each of the hollow pins in turn with a target animal cell colony location, introducing the hollow pin into the medium, and aspirating the animal cell colony into the hollow pin. In the case of an adherent colony, the distal end of the pin is forced into oscillation to detach the animal cell colony prior to aspiration. The animal cell colony is dispensed into a well plate by increasing pressure in the fluid conduit.02-02-2012
20120028238ANIMAL CELL COLONY PICKING APPARATUS AND METHOD - Animal cell colonies are picked up automatically by an apparatus having a picking head with a plurality of hollow pins and an integrated imager for capturing an image of adherent or non-adherent animal cell colonies held in liquid or semi-solid medium. Image processing identifies the locations of the animal cell colonies to be picked. Picking an animal cell colony is performed by aligning each of the hollow pins in turn with a target animal cell colony location, introducing the hollow pin into the medium, and aspirating the animal cell colony into the hollow pin. In the case of an adherent colony, the distal end of the pin is forced into oscillation to detach the animal cell colony prior to aspiration. The animal cell colony is dispensed into a well plate by increasing pressure in the fluid conduit.02-02-2012
20120028237ANIMAL CELL COLONY PICKING APPARATUS AND METHOD - Animal cell colonies are picked up automatically by an apparatus having a picking head with a plurality of hollow pins and an integrated imager for capturing an image of adherent or non-adherent animal cell colonies held in liquid or semi-solid medium. Image processing identifies the locations of the animal cell colonies to be picked. Picking an animal cell colony is performed by aligning each of the hollow pins in turn with a target animal cell colony location, introducing the hollow pin into the medium, and aspirating the animal cell colony into the hollow pin. In the case of an adherent colony, the distal end of the pin is forced into oscillation to detach the animal cell colony prior to aspiration. The animal cell colony is dispensed into a well plate by increasing pressure in the fluid conduit.02-02-2012
20130101982FLUID MIXING SYSTEMS WITH ADJUSTABLE MIXING ELEMENT - A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm.04-25-2013
20130101983NON CONTACT REAL TIME MICRO POLYMERASE CHAIN REACTION SYSTEM AND METHOD THEREOF - The present disclosure provides a non contact real time micro Polymerase Chain Reaction [PCR] system comprises; a chip having a reaction chamber for holding a sample and an embedded metal heater below the reaction chamber for heating the sample; an optical unit comprising associated LED driver and photo detector amplifier placed above the chip to detect the fluorescence; an induction heater mounted around the chip and is inductively coupled to the metal heater; an infrared temperature sensor mounted below the chip for measuring a temperature of the metal heater, wherein said infrared temperature sensor is interfaced with a signal conditioner; and a controller interfaced with the signal conditioner and the induction heater for regulating the power to the induction heater based on feedback received from the infrared temperature sensor through the signal conditioner.04-25-2013
20120070817ACOUSTIC-ASSISTED ITERATIVE WAVE FORM OPTIMIZATION FOR DEEP TISSUE FOCUSING - A method, apparatus, and article of manufacture for irradiating one or more targets within a sample with electromagnetic (EM) radiation. One or more targets within the sample are controllably defined with an acoustic field. The sample is irradiated with input EM radiation having an input wavefront. An amount of frequency shifted EM radiation is detected, wherein at least some of the input EM radiation that passes through the acoustic field at the targets is shifted in frequency to form the frequency shifted EM radiation. The input wavefront is modified, using feedback comprising the amount of the frequency shifted EM radiation that is detected, into a modified wavefront. The sample is irradiated using the input EM radiation comprising the modified wavefront, and the process is repeated as desired.03-22-2012
20130209986METHOD FOR ENHANCING BUTYRATE PRODUCTION BY CLOSTRIDIUM TYROBUTYRICUM - Disclosed is a method for enhancing a butyrate production by 08-15-2013

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