Entries |
Document | Title | Date |
20080206441 | Ion Beam Etching a Surface of an Implantable Medical Device - An implantable medical device capable of delivering therapeutic substances includes a roughened surface formed by ion beam etching. Ionized gas particles are shot at the medical device at high velocity to ablate portions of the surface of the medical device. The medical device, or a portion thereof, can be coated with a coating containing a therapeutic substance or substances, a polymer, or a combination of therapeutic substances and polymer. The coating can be made of one or more layers and the various layers can include different therapeutic substances, polymers, or combinations of therapeutic substances and polymers. The roughened surface has a greater surface area than a smooth surface, providing a better mechanical hold for the coating, thereby improving coating retention or therapeutic substance elution. | 08-28-2008 |
20080206442 | CONTACT COATING OF PROSTHESES - A method an apparatus for coating prostheses via contact patterning with an applicator. Applicators can include rollers, tampons, and ribbons. Coating materials include a variety of substances including polymers and therapeutic agents. | 08-28-2008 |
20080213464 | METHODS OF APPLYING COATING TO THE INSIDE SURFACE OF A STENT - A method of applying a coating material to a stent includes the steps of providing a generally tubular stent having an inside surface and an outside surface and applying a coating material to the inside surface of the stent without applying that coating material to the outside surface of the stent. The method may comprise providing a mandrel having a diameter less than an interior diameter of the stent, providing the coating material around the mandrel, placing the stent around the mandrel and crimping the stent so that the inside surface of the stent contacts the coating material. Alternatively, the method may comprise providing an expandable device, providing the expandable device with the coating material such that the coating material is deliverable from the expandable device, placing the stent around the expandable device and expanding the expandable device such that the expandable device contacts the inside surface of the stent. Alternatively, the method may comprise providing an elongated material that is capable of having its diameter reduced under the application of a tensile force, providing the coating material around the elongated material, applying a tensile force to the elongated material, placing the stent around the elongated material and reducing or releasing the tensile force, thereby allowing the diameter of the elongated member to increase so that the coating material contacts the inside surface of the stent. The coating material may comprise an endothelial cell growth promoter. | 09-04-2008 |
20080233268 | Stent Spin Coating Method - A method is disclosed for spin coating a stent. The method comprises applying a coating substance to the stent; rotating the stent about an axis of rotation, the axis of rotation being perpendicular to a longitudinal axis of the stent; and rotating the stent about the longitudinal axis of the stent contemporaneously with rotating the stent about the axis of rotation. The axis of rotation can intersect a center of the mass of the stent. | 09-25-2008 |
20080241351 | USING MAGNETISM TO PREPARE A MEDICAL DEVICE - The present invention is directed to methods, processes, and systems for delivering therapeutic agent to a medical device. Under some methods, processes, and systems of the invention, particles including a magnetic material and a therapeutic agent may be directed towards a medical device via magnetic attraction. In another embodiment particles including a magnetic material may force a therapeutic agent/solvent solution into porous matrix by using a magnetic attraction. In still another embodiment, a medical device having at least a portion thereof including a magnetic material is used to attract and adhere particles comprising magnetic material and therapeutic agent to a target surface of the medical device, wherein the particles are fused to the target surface. | 10-02-2008 |
20080241352 | Micromantled drug-eluting stent - Pharmacologically active, easy-to-deploy, biomechanically compatible, inflatable endovascular, drug-eluting stent are formed of a primary expandable polymeric or metallic construct, intimately mantled with a biomechanically compatible, polymeric microporous, microfibrous, compliant, stretchable fabric formed by direct electrospinning onto the outside surface of the primary construct using at least one polymer solution containing at least one active compound, selected from those expected to control key biological events leading to in-stent restenosis. | 10-02-2008 |
20080260936 | SPREAD COATING A MEDICAL DEVICE - The present invention is directed to methods, systems, devices, and kits for coating portions of a medical device or other work piece as well as to medical devices that have themselves been coated in accord with the invention. Under methods of the invention, portions of a medical device may be selectively coated. The method may include providing a medical device, an applicator, and a spreader. A layer of coating having a thickness may then be applied to a target surface of the medical device with the applicator. When the coating is applied, the spreader can be positioned in contact with the coating to reduce the coating thickness by spreading the coating over a larger surface area of the target surface. | 10-23-2008 |
20080280026 | METHODS AND SYSTEMS FOR DEPOSITING COATING ON A MEDICAL DEVICE - The present invention is directed to methods and systems for aligning and coating a medical device during a single coating cycle. A first section of an applicator may apply a contact force to surfaces of the medical device. The contact force may align and remove surface irregularities from the medical device prior to coating the medical device with coating. The coating may be resident on a second section of the applicator. | 11-13-2008 |
20080292778 | One-step Phosphorylcholine-linked polymer coating and drug loading of stent - A one step method for drug coating an interventional device is disclosed by mixing a drug with a phosphorylcholine-linked methacrylate polymer in a liquid and applying the mixture to an interventional device, such as a stent, in a single step. | 11-27-2008 |
20080305242 | Stent Support Assembly and Coating Method - A support assembly for a stent and a method of using the same to coat a stent are provided. The support assembly provides for minimum contact between the stent and the support assembly so as to reduce or eliminate coating defects. | 12-11-2008 |
20080311281 | SYSTEM AND METHOD FOR COATING A STENT - A system for coating a stent includes a device for weighing a stent, a device for aligning the stent with a stent support, a device for coating the stent, a device for drying the stent, and a device for inspecting the stent. | 12-18-2008 |
20090017188 | METHODS FOR MAKING DRUG-ELUTING MEDICAL DEVICES - The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent. | 01-15-2009 |
20090035449 | Methods and Apparatus for Coating Stents - Various embodiments of methods and devices for coating stents are described herein. | 02-05-2009 |
20090047414 | METHOD AND APPARATUS FOR APPLICATION OF A FRESH COATING ON A MEDICAL DEVICE - A method, a kit, and an apparatus provide a coating on an implantable medical device. The apparatus includes housing, a sealed reservoir chamber disposed in the housing, a reducing template, and a reservoir access port. The sealed reservoir contains the coating material. The reducing template is sized to receive a medical device therethrough for application of the coating material. A seal breaching mechanism can be provided and adapted to breach the sealed reservoir upon activation of the apparatus. The reservoir access port, which is disposed in the housing, is adapted to fluidly couple the reducing template with the reservoir chamber upon activation of the apparatus for coating the medical device. | 02-19-2009 |
20090053393 | Stent Mandrel Fixture And Method For Reducing Coating Defects - A stent mandrel fixture for supporting a stent during the application of a coating substance is provided. | 02-26-2009 |
20090061072 | MANDREL AND METHOD FOR COATING OPEN-CELL IMPLANTABLE ENDOVASCULAR STRUCTURES - Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device. Improved coating uniformity may be achieved by providing an annular space between the luminal surface of the medical device and an axial member. Coating on the luminal surface may be minimized by providing an axial member having an outer diameter that is greater than the maximum width or length of the spray contacting the axial member after passing through the openings in the medical device. | 03-05-2009 |
20090068339 | ENDOPROSTHESES HAVING POROUS CLADDINGS PREPARED USING METAL HYDRIDES - A process for making an endoprosthesis comprising: (a) applying a powder that includes a metal hydride to a surface of a metal endoprosthesis, or precursor tubing thereof; and (b) exposing the powder to a heat source to melt the powder and liberate hydrogen gas, thereby forming a porous coating on the surface of the endoprosthesis, or precursor tubing thereof. | 03-12-2009 |
20090087541 | SPRAY COATING STENTS WITH FIXED NO. OF LAYERS - Various embodiments of methods for coating stents are described herein. One method is directed to a stent spraying apparatus calibration procedure. Another method is directed to obtaining a batch of stents where each stent has the same number of layers of coatings, and the same total amount of coating material. | 04-02-2009 |
20090148591 | Methods to improve adhesion of polymer coatings over stents - Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques. | 06-11-2009 |
20090169714 | BIOCOMPATIBLE COATINGS FOR MEDICAL DEVICES - Biocompatible coatings for implantable medical devices are disclosed. Embodiments of the invention provide methods for coating an object with a biocompatible coating wherein the device is suspended using a flowing gas during the coating process. Embodiments of the invention provide tropoelastin coatings and methods of creating tropoelastin coatings for implantable medical devices. Optionally, the biocompatible coating can be a drug eluting coating. | 07-02-2009 |
20090169715 | HYDROPHILIC COATING COMPRISING A POLYELECTROLYTE - The invention relates to a hydrophilic coating formulation which when cured results in a hydrophilic coating, wherein the hydrophilic coating formulation comprises a copolymeric polyelectrolyte. The invention further relates to a hydrophilic coating, a lubricious coating, use of a copolymeric polyelectrolyte in a lubricious coating, an article, a medical device or component and a method of forming on a substrate a hydrophilic coating. | 07-02-2009 |
20090169716 | COATING SOLUTIONS COMPRISING SURFACE ACTIVE SEGMENTED BLOCK COPOLYMERS - This invention is directed toward surface treatment of a device. The surface treatment comprises the placing of surface active segmented block copolymers to the surface of the substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method. | 07-02-2009 |
20090181159 | METHODS FOR APPLYING AN APPLICATION MATERIAL TO AN IMPLANTABLE DEVICE - Devices and methods for applying a coating to an implantable device are disclosed. A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The ultrasonic material delivery apparatus includes an ultrasonic generator. At least one of the ultrasonic material delivery apparatus and the implantable device has a positive or negative electric charge. An application material is applied to the implantable device using the ultrasonic material delivery apparatus. | 07-16-2009 |
20090181160 | METHODS FOR APPLYING AN APPLICATION MATERIAL TO AN IMPLANTABLE DEVICE - Devices and methods for applying a coating to an implantable device are disclosed. A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to a material delivery apparatus. A spray pattern of an application material is produced using the material delivery apparatus. At least a portion of the spray pattern is deflected using a focusing assembly. | 07-16-2009 |
20090214756 | Methods For Electrostatic Coating Of An Abluminal Stent Surface - A stent mandrel fixture for supporting a stent during the electrostatic application of a coating substance is provided. | 08-27-2009 |
20090232964 | Compositions for Medical Devices Containing Agent Combinations in Controlled Volumes - The present invention generally encompasses controlled-volume materials that may, for example, be in a medical device or applied on a medical device as a coating, as well as methods of applying these materials. | 09-17-2009 |
20090238949 | Methods For Coating Implantable Medical Devices - Methods for coating an implantable medical device, such as a stent, are provided. | 09-24-2009 |
20090269480 | Supercritical Fluid Loading of Porous Medical Devices With Bioactive Agents - Described herein are implantable medical devices that can be coated with polymers and/or bioactive agents with the aid of supercritical fluids and methods for coating the devices. The medical devices described herein can have at least a portion of their surface made of or formed from a porous material. The supercritical fluids are used as a carrier for the bioactive agents described. Once the bioactive agents are carried to the medical device surface, they are sequestered there, preferably in the pores. The supercritical fluid is sprayed onto the medical devices achieving precipitation of the fluid. If appropriate conditions are used in the area of precipitation, bioactive agents can penetrate into the pores of the medical device before coming out of solution and expanding. | 10-29-2009 |
20090285975 | METHODS FOR MAKING IMPLANTABLE MEDICAL DEVICES - A coated implantable medical device | 11-19-2009 |
20090291196 | Abluminal Stent Coating Apparatus And Method Using A Brush Assembly - The apparatus and method use an optical feedback system to align a brush assembly with a stent strut. Once alignment is achieved, a coating is dispensed onto the stent strut via the brush assembly and the brush assembly is moved along the stent strut to coat the stent strut. | 11-26-2009 |
20090297692 | SELF-AGGREGATING PROTEIN COMPOSITIONS AND USE AS SEALANTS - An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles. | 12-03-2009 |
20090324803 | Method for Attachment of Biomolecules to Medical Device Surfaces - A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. One method of the present invention includes immobilizing a biomolecule comprising an unsubstituted amide moiety on a biomaterial surface. Another method of the present invention includes immobilizing a biomolecule on a biomaterial surface comprising an unsubstituted amide moiety. Still another method of the present invention may be employed to crosslink biomolecules comprising unsubstituted amide moieties immobilized on medical device surfaces. Additionally, one method of the present invention may be employed to crosslink biomolecules comprising unsubstituted amide moieties in solution, thereby forming a crosslinked biomaterial or a crosslinked medical device coating. | 12-31-2009 |
20100034960 | COATING METHOD AND COATING APPARATUS - A coating method and a coating apparatus are used to apply coating material to struts of a medical device (e.g., stent) which bound openings. The method involves optically scanning the medical device to produce position information identifying positions of the struts, using the position information to calculate a predetermined position, setting an applying manner to apply the coating material based on the predetermined position, setting an applying path accommodating the applying manner, and relatively moving the medical device and an applicator head along the applying route and path while dispensing the coating material from the applicator head and applying the coating material to the struts. | 02-11-2010 |
20100055294 | METHODS AND APPARATUSES FOR COATING BALLOON CATHETERS - Embodiments of the invention relate to a method and apparatus for coating a medical device. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device. | 03-04-2010 |
20100055295 | Apparatus and Method for Selectively Coating a Medical Article - A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article. | 03-04-2010 |
20100075019 | Spraying device with improved tip and method of manufacture - The invention provides a precision spraying device having an improved atomizing end for reproducibly forming droplets from small amounts of liquid with improved operational stability and spray pattern quality as well as a method of manufacturing. The invention further provides a method for reproducibly coating substrates using the spraying device of the present invention. | 03-25-2010 |
20100092655 | Clamp Mandrel Fixture And A Method Of Using The Same To Minimize Coating Defects - A mounting assembly for supporting a stent and a method of using the same to coat a stent is disclosed. | 04-15-2010 |
20100098834 | MOUNTING ASSEMBLY FOR A STENT AND A METHOD OF USING THE SAME TO COAT A STENT - A mounting assembly for a stent and a method of coating a stent using the assembly are provided. | 04-22-2010 |
20100104734 | COATED STENT AND METHOD OF MAKING THE SAME - A coated implantable medical device and a method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity. A pre-screening method for a manufacturing lot of coated stents to determine the number of drug coating layers for a desired drug release rate is disclosed. The method including coating and testing small groups of stents, and applying the results of the tests to determine the number of drug coating layers to apply to the manufacturing lot of stents. | 04-29-2010 |
20100112189 | METHOD FOR FIXING ANTIBODY ON THE SURFACE OF MEDICAL INSTRUMENT - A method for fixing antibody on the surface of medical instrument, mainly includes: 1) pre-treating the instrument surface; 2) preparing holes: preparing multicrystal phase structure which has same size holes in the surface of the instrument by chemical corrosion, electrochemical corrosion, anodic oxidation, micro-arc oxidation, micro-arc nitridation; 3) post-treating the instrument surface; 4) fixing the antibody: immerging the bare metal scaffold which has holes in surface into a buffer solution containing antibody, adjusting the pH value of the antibody buffer solution, fixing the antibody on the surface of the instrument by the attraction between positive and negative charge and hole effect; and 5) confirming the effectiveness of the fixed antibody by artificial simulation hemodynamics and detecting method of antibody activity in scaffold surface. The method can promote the firm degree of the antibody which is fixed on the surface of the instrument, and keep high activity of the antibody on the surface of medical instrument. | 05-06-2010 |
20100119695 | ANTIMICROBIAL MATERIALS AND COATINGS - An antimicrobial material is provided for use in forming textiles, medical devices, packaging materials, and the like, or coatings thereon. In some embodiments, the antimicrobial material may be utilized for bulk modification of an article. The antimicrobial material includes a furanone possessing vinyl and/or acrylate functional groups, optionally in combination with another monomer possessing vinyl and/or acrylate groups. | 05-13-2010 |
20100119696 | MANUFACTURE OF AN ORGAN IMPLANT - Methods, system and apparatus for relieving pressure in an organ such as, but not limited to, the eye are disclosed. The method includes implanting a bioabsorbable channel into the selected area of the organ using a delivery apparatus. | 05-13-2010 |
20100136212 | METHOD FOR FABRICATING MATERIAL - A diamond-like carbon film (DLC film) is formed on the surface of a base material made of an inorganic material, such as ceramics, or the like, or an organic material, such as resin, or the like. The surface of the resultant DLC film is treated with plasma, or the like, so as to be activated. Various monomers having biocompatibility, etc., are graft-polymerized to the activated surface of the DLC film, whereby a polymer layer is formed from the monomers grafted to the surface of the DLC film. Thus, the base material coated with the DLC film modified with a polymer which does not readily separate can be realized. | 06-03-2010 |
20100136213 | Thermal Treatment of a Drug Eluting Implantable Medical Device - A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition such as a temperature above the glass transition temperature of a polymer included in the coating. | 06-03-2010 |
20100159119 | Dry Diazeniumdiolation Methods for Producing Nitric Oxide Releasing Medical Devices - The methods of the present disclosure in a broad aspect provide for dry diazeniumdiolation procedures for producing nitric oxide releasing medical devices. These medical devices may alternatively have cap coats applied prior to dry diazeniumdiolation to produce nitric oxide releasing medical devices with cap coats. | 06-24-2010 |
20100173066 | COATED STENT WITH GEOMETRY DETERMINATED FUNCTIONALITY AND METHOD OF MAKING THE SAME - The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to compression forces. Exemplary embodiments provide a stent that is coated in a manner that limits the amount of coating surface area that is in direct contact with the target lumen. In particular, a covered stent is provided that is coated internally such that the outer scaffolding surface of the stent is raised from the outer surface of the coating. To this end, cilia function is only partially limited and mucociliary clearance is not significantly affected. Moreover, the coating itself has anti-adherent properties such that bacteria, fungi or other microbials cannot colonize the cover in particular and the stent generally. | 07-08-2010 |
20100183798 | METHODS FOR MANUFACTURING AMINO ACID MIMETIC COPOLYMERS AND USE OF SAME - A method of using a biocompatible polymer is used. Biocompatible polymers are manufactured to include an ammo acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties. | 07-22-2010 |
20100183799 | Stent Coating Method And Apparatus - An apparatus includes a mandrel for supporting a stent during a composition deposition process. The mandrel includes an elongated body for insertion into a longitudinal bore of a stent. The body comprises carbide. | 07-22-2010 |
20100215833 | COATING FOR MEDICAL DEVICE AND METHOD OF MANUFACTURE - The invention relates to a medical device with a base body and a coating, wherein the coating exhibits film or lacquer-forming terpenoids. In addition, the coating of the medical device can exhibit at least one application-specific additive. | 08-26-2010 |
20100221409 | Stent Fixture Having Rounded Support Structures and Method for Use Thereof - A stent fixture for supporting a stent during the application of a coating substance is provided. | 09-02-2010 |
20100227044 | Holding device and method for coating a substrate - A holding device and method is provided for efficiently applying a coating on the exterior surface of a tubular hollow body, while preventing coating application on the interior surface and coating defects. The holding device of the present invention comprises at least two structures contacting the inner surface of the tubular hollow body and extending to a portion where the structures are connected and rotary motion is induced to rotate the tubular hollow body. The structures are arranged and shaped so that an inner hollow section is formed in which excess coating material can accumulate. | 09-09-2010 |
20100227045 | Multi-purpose holding device - This invention relates to a multi-purpose holding device to handle, support and rotate one or more hollow cylindrical objects. The holding device consists of a rigid frame and support members for precise alignment and rotation of one or more objects within the frame structure. A method is also provided to reproducibly support, rotate and inspect the hollow cylindrical objects. | 09-09-2010 |
20100272882 | ENDOPROSTHESE - A coating having a smooth orange peel morphology is formed on an adluminal surface of a stent, concurrently with the formation of a coating having a rough rice grain morphology on an abluminal surface of the stent. During the formation of the two coatings, a mandrel is placed adjacent to the adluminal surface of the stent but does not generally contact the adluminal surface. | 10-28-2010 |
20100285203 | Stent Coating Method - An apparatus and method for coating abluminal surface of a stent is described. A method for coating a stent can include stent mounting, stent movement, and droplet excitation. A method can include applying a coating to a stent, the applying including generating waves in a coating solution to eject droplets of the coating solution from a surface of the coating solution toward the stent, the generating performed by transducers submerged in the coating solution. | 11-11-2010 |
20100297334 | Variable Stiffness Catheter Assembly - A catheter comprising an outer shaft comprising a first section of electroactive polymer. The first section of electroactive polymer affecting either the flexibility of the catheter or the steerability of the catheter. | 11-25-2010 |
20100304007 | ADHESION PROMOTING TEMPORARY MASK FOR COATED SURFACES - An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized. | 12-02-2010 |
20100323093 | Method of Drying Bioabsorbable Coating Over Stents - Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed. | 12-23-2010 |
20110003068 | Thermal Treatment Of An Implantable Medical Device - A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device. | 01-06-2011 |
20110008529 | Thermal Treatment Of An Implantable Medical Device - A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device. | 01-13-2011 |
20110045164 | PATTERNED MOLD FOR MEDICAL DEVICE - An apparatus and method for imprinting a pattern on a medical device to provide a surface with greater surface area and improved adhesion properties. | 02-24-2011 |
20110059227 | System and Method for Coating a Stent - A systems and method for reducing coating defects on a stent may involve a support apparatus comprising wire cage for carrying a stent. The support apparatus may have no structure that extends inside the stent. A support apparatus may include a plurality of wires that pass through the stent but do not pass through the midplane of the stent. A support apparatus may contact only the proximal ends of the stent. The method may involve keeping the stent in motion during a spray coating process to prevent the stent from having a point remain in continuous contact with a support apparatus. | 03-10-2011 |
20110059228 | Drug-Eluting Coatings Applied To Medical Devices By Spraying And Drying To Remove Solvent - A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a heat nozzle configured for applying a uniform drying gas. A coating process using the dryer includes a closed-loop control for the gas between drying steps and an improved nozzle for producing more consistent spray patterns. | 03-10-2011 |
20110070357 | Apparatus and Methods for Loading a Drug Eluting Medical Device - Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent. | 03-24-2011 |
20110070358 | Method of forming hollow tubular drug eluting medical devices - A method of a forming a hollow, drug-eluting medical device includes utilizing a hollow wire having an outer member and a lumen of the outer member, and filling the lumen with a fluid to form a supported hollow wire. The supported hollow wire is shaped into a stent pattern. Openings are formed through the outer member. The supported hollow wire is processed to remove the fluid from the lumen of the outer member without adversely affecting the outer member, leaving the hollow wire shaped into a stent pattern. The lumen is filled with a biologically or pharmacologically active substance. | 03-24-2011 |
20110076386 | Stent Fixture and Method for Reducing Coating Defects - A stent fixture for supporting a stent during formation of a coating is provided. | 03-31-2011 |
20110086162 | Concentration Gradient Profiles For Control of Agent Release Rates From Polymer Matrices - The present invention generally encompasses methods of coating which control of the release rate of agents from a polymeric matrix. This control over the release rate of agents provides for control over, inter alia, the therapeutic, prophylactic, diagnostic, and ameliorative effects that are realized by a patient in need of such treatment. In addition, the control of the release rate of agents also has an effect upon the mechanical integrity of the polymeric matrix, as well as a relationship to a subject's absorption rate of the absorbable polymers. | 04-14-2011 |
20110091639 | Medical Device Coating Configuration and Method for Improved Lubricity and Durability - Medical devices and methods for making and using the same. An example medical device includes a slotted tubular member and a coating disposed over the tubular member. The coating may define one or more coating gaps therein. | 04-21-2011 |
20110123704 | DRUG-DELIVERY ENDOVASCULAR STENT AND METHOD FOR TREATING RESTENOSIS - A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments and a liquid-infusible mechanical anchoring layer attached to or formed in outer surface of the filaments. A drug coating in the stent is composed of a substantially polymer-free composition of an anti-restenosis drug, and has a substratum infused in the anchoring layer and a substantially continuous surface stratum of drug that is brought into direct contact with the vessel walls at the vascular site. Thus, the rate of release of the anti-restenosis drug from the surface stratum into said vascular site is determined solely by the composition of said drug coating. | 05-26-2011 |
20110135806 | MANUFACTURING METHODS FOR COVERING ENDOLUMINAL PROSTHESES - The disclosure relates to a method for coating a target. The method includes providing a target and an electrospinning apparatus. The target comprises a first surface and an opposing second surface. The electrospinning apparatus comprises a mandrel, a mask including an aperture, a reservoir loaded with a solution, and an orifice fluidly coupled to the reservoir. The mandrel is located adjacent the target second surface. The orifice is located at a distance from the target first surface. The mask is located intermediate the orifice and the target first surface. The solution is electrospun through the mask aperture onto the target first surface. In one example the target is an endoluminal prosthesis. | 06-09-2011 |
20110151104 | POLY(ESTER AMIDE)-BASED DRUG DELIVERY SYSTEMS WITH CONTROLLED RELEASE RATE AND MORPHOLOGY - A method of forming a coating on a medical device having a controlled morphology is described. | 06-23-2011 |
20110159169 | DRUG RELEASING COATINGS FOR MEDICAL DEVICES - The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers. | 06-30-2011 |
20110217450 | Method for Coating Stents - A method for coating a stent can involve a device having a drying zone, a spray zone, and movable member for positioning a stent in the drying zone and another stent in the spray zone. Each stent can be on a support. A force can be applied to the outside surface of a stent to prevent rotation of the stent with respect to the support. | 09-08-2011 |
20110229627 | ELECTROSPRAY COATING OF OBJECTS - Electrospray methods and systems for coating of objects (e.g., medical devices such as a stent structure) with selected types of coatings (e.g., open matrix coating and closed film coating) | 09-22-2011 |
20110244112 | STENT COATING METHOD - A stent is coated by ejecting droplets of a coating substance from a reservoir containing a coating substance. A reservoir housing can have a plurality of reservoir compartments. A transducer is used to eject the coating substance from the reservoir. Energy from the transducer is focused at a meniscus or an interface between the coating substance and another coating substance in the reservoir. | 10-06-2011 |
20110262621 | METHOD OF LOADING BENEFICIAL AGENT ON A PROSTHESIS - A beneficial agent can be loaded as discrete droplets on a prosthesis, such as a stent. Relative movement between the prosthesis and a dispensing element can be controlled to define a dispensing path in a raster format. The discrete droplets can be dispensed from a dispensing element when the dispensing element is detected to be in alignment with a cavity formed in the prosthesis such that the discrete droplets are deposited in the cavity. The discrete droplets can be dispensed from a dispensing element when the dispensing element is detected to be in alignment with a structural element of the prosthesis such that the discrete droplets are deposited on the structural element. | 10-27-2011 |
20110274821 | HEPARIN COATINGS - The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example, methacrylates. The macromers may also be made into polymers of at least two macromers polymerized together. These polymers are preferably multi-armed or high-molecular weight and used for medical uses, for example, making coatings on medical devices. Macromers of N-vinylpyrrolidone are also disclosed herein. | 11-10-2011 |
20110274822 | ROTATABLE SUPPORT ELEMENTS FOR STENTS - Various embodiments of methods and devices for coating stents are described herein. | 11-10-2011 |
20110274823 | APPLICATION OF A COATING ON A MEDICAL DEVICE - Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating. | 11-10-2011 |
20110305819 | METHOD OF COATING STENTS - A method of coating a stent involves modifying a spray coating parameter until a target mass per coating layer is achieved. A method for coating involves spraying a batch of stents according to spraying parameters that were previously determined to provide a target mass per coating layer. | 12-15-2011 |
20110311713 | SYSTEMS AND METHODS FOR ROTATING AND COATING AN IMPLANTABLE DEVICE - A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The implantable device is rotated at a relative speed. The relative speed may be more than 120 revolutions per minute. An application material is applied to the implantable device using the ultrasonic material delivery apparatus. The relative speed may be sufficient to reduce the size of at least a portion of droplets of the application material. A system for rotating an implantable device is disclosed. The system includes an implantable device and a rotation system configured to rotate the implantable device. A longitudinal axis of the implantable device and a longitudinal axis of a rotation member of the rotation system may be offset a desired dimension. An inside diameter of the implantable device may be larger than an outside diameter of a rotation member. | 12-22-2011 |
20110311714 | Fluidized Bed Pyrocarbon Coating - Arrangements are provided for assembling multiple substrates for coating within a fluidized bed coater so as to deposit a coating of uniform thickness across the entire exterior surface thereof. One embodiment includes a method for coating orthopedic implants having convex and concave surfaces with pyrocarbon by pyrolytic decomposition of a hydrocarbon. | 12-22-2011 |
20120009325 | Method of Making a Stent with Hollow Struts - A stent including hollow struts is formed on a cylindrical substrate. The struts of the stent are formed by electroforming metal layers of the strut in openings formed in a patterned photoresist material. A first metal layer forming the inner strut material is formed in openings in a first photoresist material. A sacrificial material to form the cavity to make the struts hollow is formed in openings in a second photoresist material. A second metal layer forming the side walls and outer wall of the struts is formed in openings in a third photoresist material and around the sacrificial material. The photoresist materials are removed. The substrate and cavity sacrificial material are removed, leaving hollow struts formed into a stent pattern. The hollow struts may be filled with a therapeutic substance for elution. Openings through the struts to the cavity may be formed during the forming process. | 01-12-2012 |
20120009326 | ROTATABLE SUPPORT ELEMENTS FOR STENTS - Various embodiments of methods and devices for coating stents are described herein. | 01-12-2012 |
20120058249 | METHOD OF MAKING IMPLANTABLE DEVICES WITH REDUCED NEEDLE PUNCTURE SITE LEAKAGE - A prosthetic implantable device that offers a reduction in fluid loss when the device is punctured, such as by a dialysis needle or suture needle, and the needle is subsequently removed. The device may be made to be thin and flexible, and with longitudinal stretch, in order that it also offers good handling and kink resistance to a surgeon. While the device is preferably of tubular form, flat sheets or other forms may also be made. The device includes inner and outer layers of a porous material having a microstructure of nodes interconnected by bent fibrils, and having void spaces between adjacent bent fibrils. The inner and outer layers are joined by an elastomeric adhesive that may interpenetrate the void spaces of the adjacent surfaces of the inner and outer layers, that is, the inner surface of the outer layer and the outer surface of the inner layer. | 03-08-2012 |
20120070562 | Apparaus and Methods for Loading a Drug Eluting Medical Device - Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent. | 03-22-2012 |
20120070563 | Apparatus and Methods for Loading a Drug Eluting Medical Device - Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent. | 03-22-2012 |
20120100279 | METHOD AND DEVICE FOR COATING CATHETERS OR BALLOON CATHETERS - In a method and apparatus for coating catheters or balloon catheters the catheter or balloon catheter is radially surrounded completely or almost completely at a constant distance by a device that applies a coating solution so that the coating solution completely fills the space between the catheter or balloon catheter and the device and thus completely surrounds the catheter or balloon catheter, relative motion is effected between the device and the catheter or balloon catheter in the axial direction across the surface of the catheter or balloon catheter multiple times, and partial drying of the applied coating solution occurs between the individual coating stages. | 04-26-2012 |
20120114832 | CALCIUM PHOSPHATE COMPLEX, AND METHOD FOR PRODUCTION THEREOF - Provided is a means for fixing calcium phosphate onto the surface of a metal by a treatment method which uses no acid and produces less residue. A method of producing a calcium phosphate composite in which calcium phosphate is bonded to the surface of a base material, the method including a surface treatment step of bringing the surface of the base material into contact with a surface treating agent, and then into contact with a silane coupling agent, to surface treat the base material; a polymerization step of initiating, after the surface treatment step, polymerization of the silane coupling agent by means of a polymerization initiator; and a bonding step of bonding the silane coupling agent at the surface of the base material after the polymerization step, with calcium phosphate; wherein the base material is a metal, and the surface treating agent is ozone water. | 05-10-2012 |
20120135131 | RGD PEPTIDE ATTACHED TO BIOABSORBABLE STENTS - Provided herein is a method of forming medical device that includes RGD attached to the device via a spacer compound. The method comprises providing a spacer compound comprising a hydrophobic moiety and a hydrophilic moiety, grafting or embedding the spacer compound to the surface layer of the polymer to cause the hydrophobic moiety to be grafted to or embedded within the surface layer of polymer, and attaching a chemo-attractant to the hydrophilic moiety. | 05-31-2012 |
20120135132 | METHOD AND DEVICE FOR LOADING MEDICAL APPLIANCE WITH DRUGS AND/OR POLYMERS - A method for loading a medical appliance with a medicament and/or a polymer is disclosed, the medical appliance comprising one or more grooves or holes loaded with the medicament and/or polymer. The method comprising the steps of: 1) capturing an image of the grooves or holes of the medical appliance, wherein the image contains at least one complete pattern of the grooves or holes; 2) performing digital image processing on the captured image to obtain the pattern of the grooves or holes; 3) calculating a central position of the pattern of the grooves or holes, and determining an actual central position of the grooves or holes based on the central position; 4) adjusting a relative position of a loading device to the medical appliance to align an outlet of the loading device with the actual central position of the grooves or holes; and 5) opening the outlet of the loading device to load the grooves or holes. A device for loading a medical appliance with a medicament and/or a polymer is further disclosed. | 05-31-2012 |
20120141656 | NEEDLE-TO-NEEDLE ELECTROSPINNING - An electrospinning apparatus may include a first spinneret and a second spinneret, each including a reservoir and an orifice. The first and second spinnerets may have first and second electrical charges, respectively. The first spinneret orifice may be located substantially opposite the second spinneret orifice. The first and second spinnerets may be used to prepare a medical device defining a lumen with a proximal end, a distal end, a luminal surface and an abluminal surface. The first spinneret orifice distal end may be configured to be located outside of the medical device lumen and between about 0.1 inches and about 6.0 inches from the medical device abluminal surface. The second spinneret orifice distal end may be configured to be located in the medical device lumen and between about 0.1 inches and about 6.0 inches from the medical device luminal surface. | 06-07-2012 |
20120171353 | Efficient Path Coating on Labcoat IPMP Coating System - A method of coating a medical prosthesis includes identifying coating points on the surface of the medical prosthesis and determining a coating pathway along which an applicator travels while coating the medical prosthesis. In some embodiments, the coating pathway minimizes the rotational movement of the medical prosthesis during the coating process. In other embodiments, the coating pathway minimizes the amount of time needed for the coating process. | 07-05-2012 |
20120171354 | IMPLANTABLE MEDICAL DEVICES - The present invention is directed to methods for producing a coated substrate, including dissolving at least one biomolecule to form a solution; nebulizing the solution to form a liquid aerosol; combining the liquid aerosol and a plasma to form a coating; and depositing, in the absence of reactive monomers, the coating onto a substrate surface. In an aspect, the substrate can be an implantable medical device. | 07-05-2012 |
20120219696 | Methods Of Loading A Hollow Stent Using A Solvent - A method of loading a composition into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition that is injected may include a therapeutic agent, and it includes a solvent and optionally an excipient. The solvent has a low boiling point, such as less than a temperature of 20° C., and the solution is injected at a condition of temperature and pressure such that the solution is a liquid or a supercritical fluid state. | 08-30-2012 |
20120219697 | Methods for Covalently Attaching Molecules on Surfaces and Producing Non-fouling Surfaces - The present invention relates to methods of modifying the chemical structure of a surface by covalently attaching molecules containing desired functional groups on the surface using plasma energy. In these methods, chemical compounds containing the desired functional groups and having a vapor pressure lower than 0.001 bar are exposed in the plasma chamber together with the substrate. Surface area of the chemical compound is optimized to generate adequate evaporation rate. The modification of the substrate surface is achieved in a plasma state generated from the vapor of the chemical compounds; while the evaporation of the chemical compounds is accelerated by the plasma energy. Methods for producing non-fouling surface by covalently attaching ethylene glycol oligomers on the surface are disclosed. | 08-30-2012 |
20120225186 | In-line Bubble Removal Mechanism - A mechanism for preventing or inhibiting bubbles of dissolved gasses from outgassing due to phase change phenomenon of the pressure differential inside a liquid-filled incompressible line can be provided. This mechanism may be useful in a variety of applications, such as coating of stents and scaffolds. | 09-06-2012 |
20120276280 | METHOD AND SYSTEM FOR COATING INSERTABLE MEDICAL DEVICES - A coating system for coating an Insertable Medical Device (IMD) with one or more drugs is disclosed. The coating system includes a spray nozzle unit for coating the IMD with one or more drugs. The IMD includes a guiding member, a coating member and a supporting member. The IMD is passed through a protection tube such that the guiding member is located within the protection tube and an end of the supporting member is connected to a holder to expose the coating member of the IMD to the spray nozzle unit. The protection tube is received by a mandrel fixture which includes a circular disc for holding and rotating the protection tube and the IMD within the protection tube. When the protection tube along with the IMD is rotated, the spray nozzle unit coats the coating member of the IMD with the one or more drugs. | 11-01-2012 |
20120282391 | ENDOLUMINAL IMPLANTABLE SURFACES, STENTS, AND GRAFTS AND METHOD OF MAKING SAME - A method of manufacturing an endoluminal implantable surface, stent, or graft includes the steps of providing an endoluminal implantable surface, stent, or graft having an inner wall surface, an outer wall surface, and a wall thickness and forming a pattern design into the endoluminal implantable surface, stent, or graft. At least one groove is created in the inner surface of the intravascular stent by applying a laser machining method to the inner surface. | 11-08-2012 |
20120282392 | MEDICAL DEVICE COATING PROCESS - Methods for coating medical devices for implantation within a body vessel are provided comprising providing a cylindrical container, placing a medical device inside the cylindrical container, and applying a polymer in liquid form inside the container. | 11-08-2012 |
20120321778 | Method For Electrostatic Coating Of A Medical Device - A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device. | 12-20-2012 |
20120328770 | Methods For Modulating The Release Rate Of A Drug-Coated Stent - Methods for modulating the release rate of a drug coated stent are disclosed. | 12-27-2012 |
20130004650 | Intraluminar perforated radially expandable drug delivery prosthesis and a method for the production thereof - A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface. | 01-03-2013 |
20130011545 | METHOD FOR SELECTIVE COATING OF ENDOLUMINAL PROSTHESES - A system and method for coating an endoprosthesis involves an applicator capable of delivering a coating substance to the endoprosthesis without spraying. The applicator may have a tube or die through which a coating substance is moved upwards by capillary action or by means of a pump so as to form an accumulation of the coating substance at an upper portion of the applicator. The endoprosthesis can be lowered onto the accumulation, then axially translated or rotated in order to transfer the coating substance to selected portions of the endoprosthesis. The applicator is lowered and/or the endoprosthesis is raised in order to form gaps in the coating. Selective coating of abluminal or luminal surface of the endoprosthesis may also be performed by allowing the surface to skip on a liquid surface of a pool of the coating substance. | 01-10-2013 |
20130017312 | METHODS OF MANUFACTURE OF BIORESORBABLE AND DURABLE STENTS WITH GROOVED LUMENAL SURFACES FOR ENHANCED RE-ENDOTHELIALIZATIONAANM Pacetti; Stephen D.AACI San JoseAAST CAAACO USAAGP Pacetti; Stephen D. San Jose CA US - Methods of making bioabsorbable stents with grooved lumenal surfaces for enhanced re-endothelialization are disclosed. Methods include molding grooves on the lumenal surface of coated bioresorbable and durable stents. Methods further include molding grooves on lumenal surfaces of a bioresorbable tube and forming a scaffold from the tube. | 01-17-2013 |
20130017313 | METHOD FOR FABRICATING MEDICAL DEVICES WITH POROUS POLYMERIC STRUCTURES - Medical articles with porous polymeric structures and methods of forming thereof are disclosed. The porous structure can have pores sizes that are nanoporous or greater than nanoporous. The porous structure can be a coating or layer of a medical device such as a stent, stent graft, catheter, or lead for pacemakers or implantable cardioverter defibrillators. Additionally, the body of the medical device can be a porous polymeric structure. The porous structure can be made from bioabsorbable polymers. The porous structures can be formed by contacting a polymer with a supercritical fluid. | 01-17-2013 |
20130017314 | METHOD FOR FABRICATING MEDICAL DEVICES WITH POROUS POLYMERIC STRUCTURES - Medical articles with porous polymeric structures and methods of forming thereof are disclosed. The porous structure can have pores sizes that are nanoporous or greater than nanoporous. The porous structure can be a coating or layer of a medical device such as a stent, stent graft, catheter, or lead for pacemakers or implantable cardioverter defibrillators. Additionally, the body of the medical device can be a porous polymeric structure. The porous structure can be made from bioabsorbable polymers. The porous structures can be formed by contacting a polymer with a supercritical fluid. | 01-17-2013 |
20130064966 | Method and Apparatus for Coating a Stent - A method of coating a stent comprises contacting a first axial portion of a stent with a support element, such that a second axial portion does not contact the support element or any other support element, applying a coating material to the second axial portion, and inhibiting or preventing application of the coating material on the first axial portion. A shuttle sheath can be used to push the stent off the support element. | 03-14-2013 |
20130071549 | Dryers For Removing Solvent From A Drug-Eluting Coating Applied To Medical Devices - A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a dryer having a telescoping plenum which provides a drying chamber for the stent or scaffold to reside while a heated gas is passed over the stent/scaffold. The drying chamber improves efficiency in drying, predictability or drug release rate, uniformity of coating material properties lengthwise over the stent/scaffold and provides a platform that can effectively support stents that are over 40 mm in length. | 03-21-2013 |
20130071550 | Self-Sealing PTFE Graft with Kink Resistance - A self-sealing vascular graft, including a substrate with a sealant layer and several optional additional layers, is described. The substrate can be ePTFE and the material used for the sealant and additional layers can be polyurethane. The sealant layer and additional layers may include one or more base layers, one or more foam layers, beading of different sizes and shapes, and ePTFE tape. A flared cuff may be integral to one or both ends of the substrate or may be attached to one or both ends. Various methods of making a self-sealing vascular graft are also described, including methods of disposition, methods of forming, methods of bonding and methods of attaching. | 03-21-2013 |
20130089655 | Device and Method for Making Replacement Heart Valve - A method and device for marking suture holes in a replacement heart valve leaflet are herein provided. The method includes providing a die having a plurality of posts, each post corresponding to suture location Ink is applied to the posts and the posts are brought into contact with the leaflet, thereby marking the locations of the suture holes on the leaflet. | 04-11-2013 |
20130115363 | METHOD OF MAKING A STENT - A method of making a stent, including preparing a solution containing a composition, the composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, including argatroban, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 3:7, the composition dissolved in a solvent selected from the group consisting of a mixture of a lower alkyl ketone and methanol, a mixture of a lower alkyl ester and methanol or a mixture of a lower halogenated hydrocarbon and methanol; coating at least an outer surface of a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces; and after the coating, removing the solvent to complete a first coated layer. | 05-09-2013 |
20130129912 | Method for Manufacturing of Drug-Releasing Stent Coated with Titanium-Oxide Thin Film - A method for manufacturing a drug-releasing stent is provided. The method includes providing a titanium precursor, a carrier gas and a reactant gas in a plasma vacuum chamber, and generating a plasma for 1 to 6 hours to form a titanium oxide thin film on the surface of a stent. The method further includes providing steam or oxygen and hydrogen in the plasma vacuum chamber and generating a low-temperature plasma for 10 minutes to 2 hours to modify the surface of the titanium oxide thin film. The method further includes reacting the titanium oxide thin film of the stent with a drug in an acidic solution and under an inert gas atmosphere at room temperature to 100° C. for 30 minutes to 4 hours to attach the drug. | 05-23-2013 |
20130142939 | Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices using Sonocrystallization - Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. | 06-06-2013 |
20130142940 | STENT SPIN COATING METHOD AND SYSTEM - A method for removing excess coating from a stent involves simultaneously applying a coating substance to the stent, rotating the stent about a first axis of rotation, and rotating the stent about a second axis of rotation parallel to the first axis of rotation. An apparatus for removing excess coating from a stent includes a first system configured to rotate the stent about an axis of rotation, a fixture configured to support the stent such that a longitudinal axis of the stent is generally parallel to the axis of rotation, and a second system configured to rotate the stent about the longitudinal axis of the stent while the stent is supported by the fixture. | 06-06-2013 |
20130149430 | Methods of forming coatings with a crystalline or partially crystalline drug for implantable medical devices using supercritical fluid assisted sorption - Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. | 06-13-2013 |
20130149431 | Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices - Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. | 06-13-2013 |
20130149432 | METHOD FOR FORMING A COATING ON A STENT - A stent has first and second members. The stent is supported by a mandrel in a first position such that the mandrel is in contact with the first member and the second member is spaced from the mandrel. A method for coating the stent includes spraying or drying the stent, placing the stent in a second position such that the first member is spaced from the mandrel and the second member is placed in contact with the mandrel, and spraying or drying the stent while the stent is supported by the mandrel in the second position. | 06-13-2013 |
20130156935 | Methods for Coating Medical Devices - Processes for coating medical devices are provided herein. The processes include heating a surface of the particles used to form the coating as the particles are being applied to the medical device. The resulting coating has improved adherence to the medical device, and does not require the use of solvents and/or water, obviating the need for any steps that otherwise might be required to remove these solvents and/or water. Sufficient adherence of the particles to the medical device may also occur without the need for heating the substrate used to form the medical device. | 06-20-2013 |
20130177696 | SYSTEMS AND METHODS FOR ROTATING AND COATING AN IMPLANTABLE DEVICE - A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The implantable device is rotated at a relative speed. The relative speed may be more than 120 revolutions per minute. An application material is applied to the implantable device using the ultrasonic material delivery apparatus. The relative speed may be sufficient to reduce the size of at least a portion of droplets of the application material. A system for rotating an implantable device is disclosed. The system includes an implantable device and a rotation system configured to rotate the implantable device. A longitudinal axis of the implantable device and a longitudinal axis of a rotation member of the rotation system may be offset a desired dimension. An inside diameter of the implantable device may be larger than an outside diameter of a rotation member. | 07-11-2013 |
20130183435 | LOW TEMPERATURE PLASMA COATING FOR ANTI-BIOFILM FORMATION - The present invention is a process for surface treatment of a fluid-contacting device where a continuous organo-silicon or organo-silicon and oxygen plasma coating is applied at a low temperature by a plasma deposition technique to at least one contacting surface of the device and devices with the process applied. The plasma coating inhibits bacterial attachment to the device and prevents biofilm formation on said device. The coating preferably has a thickness from about 1 nm to about 100 nm, more preferably from about 20 nm to about 30 nm. The trimethylsilane and oxygen gas mixture is an approximate ratio of 1 to 4. The invention demonstrates that bacterial cells on the organo-silicon or organo-silicon/O | 07-18-2013 |
20130209662 | METHODS AND APPARATUSES FOR COATING BALLOON CATHETERS - Methods and apparatus for coating a medical device are provided. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device. | 08-15-2013 |
20130209663 | IMPLANTABLE MEDICAL DEVICE WITH BENEFICIAL AGENT CONCENTRATION GRADIENT - The implantable medical devices are configured to release at least one therapeutic agent from a matrix affixed to the implantable body with a release profile which is programmable to the agent and treatment. The matrix is formed such that the concentration of the therapeutic agent in the matrix varies as a gradient relative to a surface of the implantable body. The change in the concentration gradient of the agent in the matrix directly controls the rate of elution of the agent from the matrix. The therapeutic agent matrix can be disposed in the stent or on surfaces of the stent in various configurations, including within volumes defined by the stent, such as openings, holes, or concave surfaces, as a reservoir of agent, and alternatively as a coating on all or a portion of the surfaces of the stent structure. | 08-15-2013 |
20130216695 | Drug-Eluting Coatings Applied to Medical Devices by Spraying and Drying to Remove Solvent - A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a heat nozzle configured for applying a uniform drying gas. A coating process using the dryer includes a closed-loop control for the gas between drying steps and an improved nozzle for producing more consistent spray patterns. | 08-22-2013 |
20130230637 | MEDICAL MATERIAL FOR IN VIVO IMPLANTATION CONTAINING SOFTENING AGENT AND OR MOISTURIZING AGENT, METHOD FOR CONTROLLING CONTENT OF SOFTENING AGENT AND OR MOISTURIZING AGENT IN THE MEDICAL MATERIAL, AND METHOD FOR PRODUCING THE MEDICAL MATERIAL FOR IN VIVO IMPLANTATION - A medical material for in vivo implantation contains a bioabsorbable material containing a softening agent and/or a moisturizing agent and a non-bioabsorbable porous base material, in which the content of a softening agent and/or a moisturizing agent is controlled less than 20 wt %; a method for controlling this content; and a method for producing a medical material for in vivo implantation are provided. | 09-05-2013 |
20130230638 | MEDICAL MATERIAL FOR IN VIVO IMPLANTATION CONTAINING SOFTENING AGENT AND/OR MOISTURIZING AGENT, METHOD FOR CONTROLLING CONTENT OF SOFTENING AGENT AND/OR MOISTURIZING AGENT IN THE MEDICAL MATERIAL, AND METHOD FOR PRODUCING THE MEDICAL MATERIAL FOR IN VIVO IMPLANTATION - A medical material for in vivo implantation contains a bioabsorbable material containing a softening agent and/or a moisturizing agent and a non-bioabsorbable porous base material, in which the content of a softening agent and/or a moisturizing agent is controlled less than 20 wt %; a method for controlling this content; and a method for producing a medical material for in vivo implantation are provided. | 09-05-2013 |
20130230639 | ROTATABLE SUPPORT ELEMENTS FOR STENTS - Various embodiments of methods and devices for coating stents are described herein. The method includes applying a coating composition to the stent; rotating the stent with a rotatable element supporting at least a portion of the stent; and applying at least one pulse to the rotatable element during the stent coating process. | 09-05-2013 |
20130243936 | COATING METHODS - Described herein are methods of coating both metallic and polymeric surfaces adding hydrophilicity comprising the steps mixing a coating composition comprising at least one polyol, at least one compound having at least two isocyanate groups, and an organic solvent; introducing nucleophilic functional groups on the surface thereby creating an active surface; subjecting the active surface to the coating composition thereby forming a coated surface; and curing the coated surface. Medical devices, for example, implantable medical devices can be coated by the methods described herein. | 09-19-2013 |
20130243937 | Composite stent with inner and outer stent elements and method of using the same - An endoprosthesis comprising a stent, a cover fully covering the stent wherein the cover has variable porosity in the radial direction; and an adhesion layer connecting the stent to the cover. Another aspect of the invention is a method of implanting an endoprosthesis which includes a stent, providing a cover with variable porosity in the radial direction, connecting the stent to the cover with an adhesion layer to form a covered stent, and implanting the covered stent within a body lumen of a patient. | 09-19-2013 |
20130273234 | Biocompatible Polyacrylate Compositions For Medical Applications - A composition comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety is disclosed. A medical article comprising the composition in the coating thereof and a method of fabricating the medical article are also disclosed. | 10-17-2013 |
20130287931 | METHODS OF MAKING DEVICES - The method of making devices is disclosed herein. More particularly, a method of manufacturing a device, comprises: vacuum depositing a device-forming metal onto an unpatterned, exterior surface of a generally cylindrical substrate to form a generally tubular, unpatterned crystalline metal film under at least one vacuum deposition process condition selected from at least one of chamber pressure, deposition pressure, and partial pressure of a process gas, said at least one process condition optimized to substantially eliminate formation of chemical and intra- and intergranular precipitates in the bulk material; and removing the deposited generally tubular, unpatterned crystalline metal film from the generally cylindrical substrate. | 10-31-2013 |
20140004254 | THERAPEUTIC AGENT ELUTION CONTROL PROCESS | 01-02-2014 |
20140030422 | MODIFYING POLYMER PROPERTIES WITH PENETRANTS IN THE FABRICATION OF BIORESORBABLE SCAFFOLDS - Methods of fabricating a bioresorbable polymer scaffold are disclosed including a step of inducing crystallization in a bioresorbable polymer construct through exposure to a liquid penetrant. | 01-30-2014 |
20140037833 | METHOD FOR COATING A STENT - A systems and method for reducing coating defects on a stent may involve a support apparatus comprising wire cage for carrying a stent. The support apparatus may have no structure that extends inside the stent. A support apparatus may include a plurality of wires that pass through the stent but do not pass through the midplane of the stent. A support apparatus may contact only the proximal ends of the stent. The method may involve keeping the stent in motion during a spray coating process to prevent the stent from having a point remain in continuous contact with a support apparatus. | 02-06-2014 |
20140057042 | Method for Coating and Drying Multiple Stents - A coating and drying apparatus for the application of a coating substance to a stent and drying the stent is provided. | 02-27-2014 |
20140106060 | LIQUID AND LOW MELTING COATINGS FOR STENTS - Stents with coatings comprising a combination of a restenosis inhibitor comprising an HMG-CoA reductase inhibitor and a carrier. Also provided are methods of coating stents with a combination of an HMG-CoA reductase inhibitor and a carrier. A preferred example of a restenosis inhibitor is cerivastatin. The stent coatings have been shown to release restenosis inhibitors in their active forms. | 04-17-2014 |
20140127391 | ULTRAVIOLET ACTIVATED ANTIMICROBIAL SURFACES - The invention is directed to an ion plasma deposition (IPD) method adapted to coat polymer surfaces with highly adherent antimicrobial films. A controlled ion plasma deposition (IPD) process is used to coat a metal or polymer with a selected metal/metal oxide. Exposing the coated surface to ultraviolet light significantly improves the antimicrobial properties of the deposited coatings. | 05-08-2014 |
20140134323 | METHODS OF MANUFACTURE OF BIORESORBABLE AND DURABLE STENTS WITH GROOVED LUMENAL SURFACES FOR ENHANCED RE-ENDOTHELIALIZATION - Methods of making bioabsorbable stents with grooved lumenal surfaces for enhanced re-endothelialization are disclosed. Methods include molding grooves on the lumenal surface of coated bioresorbable and durable stents. Methods further include molding grooves on lumenal surfaces of a bioresorbable tube and forming a scaffold from the tube. | 05-15-2014 |
20140147575 | BIODEGRADABLE SUPPORTING DEVICE - A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold. | 05-29-2014 |
20140154400 | METHOD OF DRYING BIOABSORBABLE COATING OVER STENTS - Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed. | 06-05-2014 |
20140186516 | COATING METHOD AND COATING APPARATUS - A coating method and a coating apparatus are used to apply coating material to struts of a medical device (e.g., stent) which bound openings. The method involves optically scanning the medical device to produce position information identifying positions of the struts, using the position information to calculate a predetermined position, setting an applying manner to apply the coating material based on the predetermined position, setting an applying path accommodating the applying manner, and relatively moving the medical device and an applicator head along the applying route and path while dispensing the coating material from the applicator head and applying the coating material to the struts. | 07-03-2014 |
20140193569 | STENT WITH PREFERENTIAL COATING - This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating. | 07-10-2014 |
20140199470 | POLYMER COMPOSITION ON SUBSTRATE AND SURFACE MODIFICATION METHOD - Provided are a polymer composition on a substrate and a surface modification method which is non-selective to substrate materials. Chemical vapor deposition polymerization is used to deposit a maleimide-functionalized poly-p-xylylene coating on a substrate. The substrate is readily available to perform a thiol-maleimide coupling reaction under mild conditions so as to modify the surface thereof. Furthermore, through a tailored thiol-terminal molecule, a designer surface can be created via thiol-maleimide coupling on a substrate, and the resulting surface can exhibit various desired biological functions for biotechnological applications. Therefore, this modification technique can be applied to biological fields extensively. | 07-17-2014 |
20140205740 | Coated Stent and Method of Making the Same - A coated implantable medical device and a method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity. A pre-screening method for a manufacturing lot of coated stents to determine the number of drug coating layers for a desired drug release rate is disclosed. The method including coating and testing small groups of stents, and applying the results of the tests to determine the number of drug coating layers to apply to the manufacturing lot of stents. | 07-24-2014 |
20140248418 | ELECTROSPUN PTFE COATED STENT AND METHOD OF USE - A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis. | 09-04-2014 |
20140272102 | INTRAOCULAR SHUNT MANUFACTURE - An intraocular shunt can be manufactured using a system that includes a liquid bath and a wire, which is moved through the bath. When moved through the bath, the wire is coated with a material, such as gelatin. For example, the liquid bath can have a top layer, including water, and a bottom layer, including gelatin. The coated wire passes through an aperture formed in a plate component of the system. The gelatin can be dried on the wire in a humidity-controlled space, thereby forming the shunt. | 09-18-2014 |
20140287134 | Coating system and method for drug elution management - The teachings are directed to a medical device having a drug-retaining coating that at least substantially delays the initial elution of a drug for a time effective at forming a functional endothelium over a surface of the medical device. | 09-25-2014 |
20140295054 | Molecular Film Containing Polymeric Mixture for Hydrophobic Implant Surfaces - Compositions are disclosed containing a polymeric mixture diluted into an aqueous solution, which can be usefully applied to any surface mat is hydbcphoixc to act, for example, as an aotifoggiag coating with minimal optical distortion and excellent transparency. The compositions can also be used as lubricious agents on medical implants, shunts, and surgical supplies to minimize tissue trauma, to maximize bio-compatibility, and to increase healing by enhancing better irrigation and flow in adjacent tissue. | 10-02-2014 |
20140314945 | GRADIENT COATED STENT AND METHOD OF FABRICATION - The gradient coated stent | 10-23-2014 |
20140356519 | ELASTIN-BASED COPOLYMERS AND METHOD OF USING - A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. | 12-04-2014 |
20140363563 | ELASTIN-BASED COPOLYMERS - A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. | 12-11-2014 |
20140377448 | METHOD FOR FORMING A COATING ON A STENT - Various embodiments of methods and devices for coating stents are described herein. | 12-25-2014 |
20150030758 | METHOD FOR ELECTROSTATIC COATING OF A MEDICAL DEVICE - A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device. | 01-29-2015 |
20150037493 | SINGLE LAYER EPTFE AND DISCRETE BIO-RESORBABLE RINGS - A stent-graft, including a generally tubular vascular graft of biocompatible material, and a plurality of bio-resorbable discrete annular members spaced apart along a longitudinal axis of the vascular graft and attached thereto. | 02-05-2015 |
20150093496 | MEDICAL DEVICE COATINGS FOR RELEASING A THERAPEUTIC AGENT AT MULTIPLE RATES - Medical device coatings are provided that simultaneously release a therapeutic agent at different rates from different portions of the medical device coating. In a first embodiment, medical device coatings are provided that include particles comprising a therapeutic agent with two or more different particles sizes within a single layer on a surface of the implantable device. In a second embodiment, medical device coatings are provided having a higher concentration of the therapeutic agent in a first region of the coating than in a second region of the coating. In a third embodiment, medical device coatings are provided that are formed by certain coating processes wherein the droplet size of a spray coating solution is changed during the coating process. These coating processes preferably include applying a solution comprising a therapeutic agent and a suitable solvent to a surface of an implantable medical device. In a fourth embodiment, methods of treatment are provided that include implanting a coated medical device. | 04-02-2015 |
20150099056 | POLYMER COATING FOR MEDICAL DEVICES - Coatings are provided in which surfaces may be activated by covalently bonding a combination of silane derivatives (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone polymer. Biologically active agents or therapeutic compounds may be deposited with any of the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents. | 04-09-2015 |
20150290363 | Stent with Albumin Coating for Enhanced Thromboresistance - Coatings for medical devices, the coatings including albumin, the methods of forming the coatings, and the coated medical devices are disclosed. In preferred embodiments the medical device is a bioabsorbable stent. The albumin coating layer improves the thromboresistance of the device. | 10-15-2015 |
20150342761 | DEVICE FOR IN VIVO DELIVERY OF BIOACTIVE AGENTS AND METHOD OF MANUFACTURE THEREOF - The drug eluting device consists of an implantable structural element for in vivo controlled delivery of bioactive active agents to a situs in a body. The implantable structural element may be configured as an implantable prosthesis, such as an endoluminal stent, cardiac valve, osteal implant or the like, which serves a dual function of being prosthetic and a carrier for a bioactive agent. Control over elution of the bioactive agents occurs through a plurality of cantilever-like cover members which prevent drug elution until an endogenous or exogenous stimulus causes the cover members to open and permit drug elution. | 12-03-2015 |
20150352262 | BIODEGRADABLE SUPPORTING DEVICE - A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold. | 12-10-2015 |
20150352340 | CATHETER BALLOON DRUG ADHERANCE TECHNIQUES AND METHODS - Various methods for optimizing coating of medical devices, such as balloon catheters are disclosed. One method configures catheter balloon folds based on balloon diameter and volume. Other methods include using a specifically-sized protective sheath, using a vacuum, using pressure, pulling the balloon through a coating solution, using at least one spacer or a wick between at least one fold for metering a therapeutic coating into the folds of the balloon, placing an intermediate layer between the balloon and the therapeutic coating, placing a soluble film having a therapeutic agent around the catheter balloon or inside the folds, and any combination thereof. Balloon catheters and catheter balloons having a specific folding configuration, a specifically-sized protective sheath, an intermediate layer, or a soluble film are also disclosed. | 12-10-2015 |
20150359647 | SOLVENT METHOD FOR FORMING A POLYMER SCAFFOLDING - Methods of making polymeric devices, such as stents, using solvent based processes. More particularly, methods of making bioabsorbable stents. | 12-17-2015 |
20160015535 | SURFACE STRUCTURE OF A COMPONENT OF A MEDICAL DEVICE AND A METHOD OF FORMING THE SURFACE STRUCTURE - A method of forming a surface structure of a component of a medical devices includes forming a fatigue-resistant portion, which entails forming a first layer comprising a transition metal selected from the group consisting of Ta, Nb, Mo, V, Mn, Fe, Cr, Co, Ni, Cu, and Si on at least a portion of a surface of the component, where the surface comprises a nickel-titanium alloy, and alloying the transition metal of the first layer with the nickel-titanium alloy of the surface. The method further includes forming a rough outer surface of the fatigue-resistant portion, where the rough outer surface is adapted for adhesion of a material thereto. | 01-21-2016 |
20160030642 | STENT WITH PREFERENTIAL COATING - This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating. | 02-04-2016 |
20160030643 | DRUG COATED STENTS - Provided herein is a coated coronary stent including a stent framework, heparin molecules attached to the stent framework and a rapamycin-polymer coating wherein at least part of rapamycin is a crystalline form. In one embodiment, the rapamycin-polymer coating comprises one or more resorbable polymers. Methods for preparing stents are also disclosed. | 02-04-2016 |
20160032145 | Coating for a Surface - Coatings for a surface, especially a priming coating, of the present invention have been found to be durable, resistant to oxidative degradation, erosion and depolymerisation, stable to sterilization and low particulating, and are easily applied to the required surface of a substrate in a surface-independent manner. Such coatings, when used as priming coatings to be coated with a subsequent coating, in at least some embodiments, form exterior coatings which are also highly durable and are stable to sterilisation and aging. | 02-04-2016 |
20160058922 | METHOD FOR DRUG LOADING HYDROXYAPATITE COATED IMPLANT SURFACES - A method for loading a hydroxyapatite coated implant with a therapeutic agent including the steps of providing an implant and applying a hydroxyapatite coating on a surface of the implant. The hydroxyapatite coated implant is contacted with a solution including the therapeutic agent. The hydroxyapatite coated implant and solution is heated to temperature of about 60° C. to about 100° C. Pressure is applied to the hydroxyapatite coated implant and solution from about 2 bar to about 10 bar, to load the hydroxyapatite coated implant with the therapeutic agent. An implant made ac cording to the method has sustained therapeutic agent delivery and includes a base and a biomimetic hydroxyapatite coating disposed on a surface thereof. | 03-03-2016 |
20160067032 | SYSTEM AND ATRAUMATIC MANDREL FOR CREATING GRAFT DEVICES - In some aspects, a system for applying a fiber matrix on a tubular conduit is provided. The system can include a tubular conduit, a mandrel and a fiber matrix delivery assembly. The mandrel can comprise an elongate shaft and a rolling membrane configured to atraumatically engage the tubular conduit. | 03-10-2016 |
20160068960 | METHOD FOR GENERATING PLASMA UNIFORMLY ON DIELECTRIC MATERIAL - The present invention relates to a method for checking a discharge inception voltage of a dielectric material, a method for forming a displacement field on the dielectric materials comprising applying a voltage the same as or higher than the discharge inception voltage generated by an external field obtained from the above to the dielectric material to which electrodes are connected, a method for forming plasma on the surfaces of the dielectric material comprising injecting reaction gases and applying a voltage the same as or higher than the discharge inception voltage obtained above to the dielectric material to which electrodes are connected, a method for forming a displacement field on the entire surface of the dielectric material comprising applying a voltage the same as or higher than the discharge inception voltage obtained above to the dielectric material to which electrodes are connected, and a dielectric material which is modified, in which the surfaces thereof are treated with plasma by the methods described above. | 03-10-2016 |
20160175493 | MODIFYING POLYMER PROPERTIES WITH PENETRANTS IN THE FABRICATION OF BIORESORBABLE SCAFFOLDS | 06-23-2016 |
20160184489 | PLASMA MODIFIED MEDICAL DEVICES AND METHODS - Coatings, devices and methods are provided, wherein the contacting surface of a medical device with at least one contacting surface for contacting a bodily fluid or tissue, wherein long-lasting and durable bioactive agents or functional groups are deposited on the contacting surface through a unique two-step plasma coating process with deposition of a thin layer of plasma coating using a silicon-containing monomer in the first step and plasma surface modification using a mixture of nitrogen-containing molecules and oxygen-containing molecules in the second step. The two-step plasma coating process enables the implantable medical device to prevent both restenosis and thrombosis under clinical conditions. The invention also relates to surface treatment of metallic and polymeric biomaterials used for making of medical devices with significantly improved clinical performance and durability. | 06-30-2016 |