Entries |
Document | Title | Date |
20080199532 | Long Lasting Natriuretic Peptide Derivatives - This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to covalently bond with a functionality on a blood component. In particular, this invention relates to NP derivatives having an extended in vivo half-life, and method for the treatment of cardio-vascular diseases and disorders such as acute decompensated congestive heart failure (CHF) and chronic CHF. | 08-21-2008 |
20080220083 | Pharmaceutical Agent Comprising Blood Components <10 Kda And Their Use For Prophylaxis And Treatment Of Defects Of The Immune System - The invention relates to a composition of proteins, peptides and/or peptide components, a pharmaceutical agent comprising said composition, a method for the production of said composition and the use thereof in the prophylaxis or therapy of persons, animals and/or patients with pathogenic modifications and/or cellular immunodeficiencies, especially cancer, septicemia or allergic reactions, in connection with a cytostatic agent therapy, chemotherapy and/or radiotherapy. | 09-11-2008 |
20080268064 | METHOD FOR TREATING CARTILAGE DEFECTS - Methods for treating a cartilage defect comprising fractioning blood to produce a blood component, shaping the cartilage defect to expose subchondral bone, microfracturing the subchondral bone, and applying the blood component to the microfractured subchondral bone. The blood component can comprise platelet-poor plasma. | 10-30-2008 |
20080279956 | Method for collecting a live placenta cord stem cell - The present invention discloses a method for collecting a live placenta cord stem cell, in which the live placenta cord stem cells are required to be healthy and plenty of endocrine. The cord is first picked with a proper length, then dipped in the sodium citrate solution of a specific concentration as an anticoagulant and then preserved in a refrigerator to maintain natural activity thereof. The collected stem cells can be implanted into human bodies without synthetic chemicals, side effects and rejection, and therefore are suitable for treating many diseases. | 11-13-2008 |
20090011043 | TISSUE SEALANT MADE FROM WHOLE BLOOD - Disclosed are tissue sealants that include whole blood and an effective amount of an exogenous protein cross-linker to cross-link the whole blood. Also disclosed are methods for forming a tissue sealant. Such methods include, providing whole blood and mixing the whole blood with an effective amount of an exogenous protein cross-linker to cross-link the whole blood into an adherent mass, thereby forming the tissue sealant. The disclosed tissue sealants can be used for any application, for example to achieve hemostasis, bond tissue of a subject and/or or seal a fluid or gas leak in a tissue of a subject. | 01-08-2009 |
20090017128 | CARBON DIOXIDE REMOVAL FROM WHOLE BLOOD BY PHOTOLYTIC ACTIVATION - Apparatus and methods for removing carbon dioxide from whole blood. Hydrogen ions are generated from water in the blood, resulting in the formation and release of carbon dioxide from the blood. | 01-15-2009 |
20090136586 | Method for Extracorporeal Removal of a Pathogenic Microbe, an Inflammatory Cell or an Inflammatory Protein From Blood - The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein/and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein. | 05-28-2009 |
20090263492 | Diagnostic Methods and Genetic Markers for Alzheimer Disease - Disclosed are methods for identifying individuals suffering from a CNS disorder (including Alzheimer's Disease, behavioral disorders, and the like) that could be treated with a CNS drug with greater therapeutic efficacy and lower side effects and the compounds useful for such treatment. Also disclosed are methods for predicting the efficacy of a drug candidate for the treatment of a CNS disorder. The technology is also applicable to drug discovery for use in animal models of neurodegenerative diseases. | 10-22-2009 |
20090311338 | CROSSLINKING METHODS AND APPLICATIONS THEREOF - Some aspects of this disclosure relate to a method for crosslinking a biological fluid comprising combining a biological fluid with a crosslinker to covalently crosslink proteins endogenous to the biological fluid to form a crosslinked gel. Examples of a biological fluid are blood, plasma, or serum. | 12-17-2009 |
20100112080 | MULTIMERIC Fc RECEPTOR POLYPEPTIDES INCLUDING A MODIFIED Fc DOMAIN - A soluble multimeric polypeptide or protein is disclosed that is able to inhibit interaction of leukocyte Fcγ receptors (FcγR) and immunoglobulin G (IgG). The protein or polypeptide comprises two or more Fc binding regions linked in a head to tail arrangement, at least one of which is derived from an FcγR type receptor, and an Fc domain of an immunoglobulin which has been modified to reduce or prevent binding to the said Fc binding regions and/or to alter effector function. Also described are polynucleotide molecules encoding the polypeptide or protein and the use thereof in methods of treating a subject for an immune-complex (IC)-mediated inflammatory disease. | 05-06-2010 |
20100159022 | BONE INDUCTION SYSTEM AND METHODS - An osteogenic composition suitable for use in bone and soft tissue reparative procedures is provided for herein. Methods for preparing osteogenic composition from blood and bone marrow are also provided for. The osteogenic compositions contain therapeutically effective concentrations of one or more osteogenic agents such as BMP-2, TGF-β, PDGF and VEGF. | 06-24-2010 |
20100183735 | METHOD FOR INDUCING SELECTIVELY SUPPRESSED IMMUNE RESPONSE TO TRANSPLANTED TISSUE OR CELLS - Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring induced anti-cancer immunity. In one embodiment, skin from the transplant donor is allografted to the transplant recipient to induce an immunological response to the transplanted skin. A quantity of blood is taken from the recipient and treated to render the T cells in the blood apoptotic and to induce differentiation of blood monocytes into dendritic cells. The treated blood is incubated and administered to the recipient to induce formation of suppressor T cell clones which reduce the number of T cells attacking the transplanted tissue or organ. This tolerogenic approach can be complemented by also feeding the immature dendritic cells apoptotic or necrotic cells from the organ donor. In a second embodiment, dendritic cells loaded with tumor antigens are injected intradermally to monitor the anti-cancer immunity induced by Transimmunization. | 07-22-2010 |
20100266707 | METHOD OF TREATING CACHEXIA WITH THE REMOVAL OR INACTIVATION OF MACROPHAGE INHIBITORY CYTOKINE-1 - A method of treating cachexia is disclosed involving the removal or inactivation of macrophage inhibitory cytokine-1 (MIC-1) present in the blood, plasma or serum of a cachexia subject. In one embodiment, the method comprises the steps of providing a suitable substrate for binding MIC-1 (e.g. a substrate provided with a MIC-1 binding molecule), treating blood, plasma or serum removed from a subject by contacting the blood, plasma or serum ex vivo with the substrate such that MIC-1 present in the blood, plasma or serum is bound to the substrate, separating the treated blood, plasma or serum from the substrate, and thereafter returning the treated blood, plasma or serum to the subject. Also disclosed, is a method of diagnosing or prognosing cachexia in a subject, said method comprising determining the amount of MIC-1 present in the subject. | 10-21-2010 |
20110027380 | CARBON DIOXIDE REMOVAL FROM WHOLE BLOOD BY PHOTOLYTIC ACTIVATION - Apparatus and methods for removing carbon dioxide from whole blood. Hydrogen ions are generated from water in the blood, resulting in the formation and release of carbon dioxide from the blood. | 02-03-2011 |
20110033554 | Method of Viral Inactivation of Biological Fluids - The invention relates to a novel method of virally inactivating biological fluids by solvent/detergent treatment of the fluid, followed by oil extraction and filtration. | 02-10-2011 |
20110111048 | PRODUCING METHOD FOR LIVING ORGANISM-APPLICABLE HYDROGEN-CONTAINED FLUID AND PRODUCING APPARATUS FOR THE SAME - A producing method for a living organism-applicable hydrogen-contained fluid, which includes hydrogen molecules in living organism-applicable fluid enclosed in a container ( | 05-12-2011 |
20110250287 | One step removal of selected molecules from body fluid and tissue - A method for reducing the number of selected antibodies in a subject's blood, the method comprising removing blood from the subject, passing the blood along an enclosed pathway, wherein the pathway comprises one or more semi-permeable hollow fibers with one or more membranes having surfaces positioned substantially perpendicular to the length of the one or more hollow fiber and antigens specific for the antibodies immobilized on the one or more membranes, returning the treated blood to the internal circulation of the subject, wherein the returned treated blood has a reduced number of selected antibodies compared to before treatment. | 10-13-2011 |
20120003323 | EYE DROPS CONTAINING A DEPROTEINIZED CALF BLOOD EXTRACT - The present invention provides an eye drops, containing an therapeutically effective amount of the deproteinized calf blood extract, chitosan oligosaccharide, and water. The eye drops of the present invention is stable, and can be used for the treatment of pathological changes of cornea and conjunctiva as well as xerophthalmia. | 01-05-2012 |
20120087987 | COMBINED USE OF TWO INSECTICIDES - The present disclosure relates to the combined use of two pesticides. A first pesticide composition provides an initial contact kill, and may form a barrier when applied to greasy surfaces. A second pesticide composition provides residual pesticidal activity on the surface. Methods of making and using the pesticide compositions are also provided. | 04-12-2012 |
20120121720 | Modulation of Beta 2 Adrenergic Receptors by Inhibitors of EGLN3 or pVHL - This present invention relates to methods, compositions, and kits useful for treating a patient having or at risk for developing a disorder associated with decreased expression of β2 adrenergic receptors or need for increased 132 adrenergic receptor activity. | 05-17-2012 |
20120195969 | TREATMENT OF ACNE BY CONDITIONED MEDIA - Disclosed are methods and compositions for treatment of acne or acneform conditions, particularly but not limited to, acne vulgaris with products generated from culture of stem or progenitor cells. Specifically, compositions of matter are disclosed which are useful for the treatment of acne and acne associated disease states, in particular acne vulgaris, by topical administration of products derived from stem cells or progenitor cells. | 08-02-2012 |
20120321721 | NOVEL FORMULATION OF PHYSIOLOGICAL CHITOSAN-INORGANIC SALT SOLUTION/BLOOD MIXTURES FOR TISSUE REPAIR - The present description relates to a polymer composition for use in repairing tissue of a patient comprising at least one blood component, a polymer, such as chitosan, and at least one inorganic salt, such as NaCl, method of using the composition and method of preparing the composition. | 12-20-2012 |
20130004581 | CONTROLLING UPTAKE BY CELLS - Methods and devices for causing uptake of materials by cells, temporary using local chemical environment modification. The modification may be caused chemically by reducing pH. The uptake method is passive and does not require bioactivity of the cells. | 01-03-2013 |
20130078311 | COMPOSITION FOR TREATING AND/OR PREVENTING OSTEOPOROSIS - The invention relates to a composition comprising deer velvet antler blood (DVAB) in combination with velvet antler for use in the treatment and/or prevention of osteoporosis and a method for treating and/or preventing osteoporosis, comprising administering a therapeutically effective amount of a composition comprising DVAB and velvet antler to a subject at risk of developing or afflicted with osteoporosis. The composition of the invention, when administered to a subject with osteoporosis, increases anti-osteoporotic activity, decreases the biomarker of osteoporosis and recovers the biomechanical strength and structure of bone, suggesting that the said composition could significantly prevent and even treat osteoporosis. | 03-28-2013 |
20130078312 | Biodegradable Putty Compositions and Implant Devices, Methods, and Kits Relating to the Same - Disclosed are phospholipid based compositions and implant devices, as well as methods and kits that include such compositions or components thereof. In particular, the present compositions include a polymer component such as a poloxamer or PEG component and a phospholipid component, such as a Phosal. The present compositions may include at least one additional component, such as granules, powder and/or particulates. The present compositions may further include one or more bone graft materials and/or active ingredients. The compositions may be used on their own or incorporated on or in a surgical implant. | 03-28-2013 |
20130236559 | METHOD AND DEVICE FOR TREATING BLOOD CHOLESTEROL DISORDERS - A method and device for treating cholesterol disorders includes administering at least one treatment regime including two or more rounds of plasmapheresis to a patient having abnormal total cholesterol, abnormal LDL levels and/or abnormal HDL levels prior to treatment. Treatment according to the method results in decreased LDL levels in patients having abnormal LDL levels and increased HDL levels in patients having abnormal HDL levels. Each subsequent round of plasmapheresis is conducted weekly, but no more than twice per week. | 09-12-2013 |
20130259951 | Apparatus and Method for Separating and Concentrating a Component of a Fluid - A system for separating and concentrating a component of a whole material is disclosed. The whole material can include a material that has more than one component, such as whole blood that can include at least red blood cells, monocytes, and plasma. The system can include a substantially single container including a separation section and a concentration section wherein a component can be moved from the separation section, after a separation, to the concentration section to be concentrated. The concentrated component can then be withdrawn from the separation and concentration container for a selected procedure. | 10-03-2013 |
20130295192 | METHOD TO IDENTIFY TISSUE OXYGENATION STATE BY SPECTROGRAPHIC ANALYSIS - A system and method for identifying metabolic activity within the heart muscle (myocardium). Metabolic activity is determined through spectrographic analysis of the myocardium. More particularly, oxygen saturation of the myocardium is measured through the spectrographic analysis, and metabolic activity is measured by a decrease in oxygen saturation of the myocardium over time. | 11-07-2013 |
20140127312 | POLYMERS FOR REVERSING HEPARIN-BASED ANTICOAGULATION - Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules. | 05-08-2014 |
20140127313 | PREVENTION AND TREATMENT OF HIV INFECTION - A pharmaceutical composition for preventing and treating HIV infection includes an active ingredient made by a process involving a series of intra- and inter-species blood transfers made among male and female animals. The process modifies the components of blood in the animals such that the blood from the last animal in the series of transfers can be used as the active ingredient in a pharmaceutical composition which, when administered to an HIV-infected human subject, can eliminate any detectable HIV in the subject. | 05-08-2014 |
20140134263 | Methods and Systems for Processing Exosomes - Methods and systems of processing exosomes from a biologic sample, including providing a biological sample having a mixed population of exosomes, wherein the mixed population of exosomes includes two or more distinct subpopulations of exosomes; and processing the biological sample to selectively remove one or more exosome subpopulations from the mixed population of exosomes thereby obtaining a sample enriched with a desired subpopulation of exosomes. | 05-15-2014 |
20140193512 | CLOTTING CASCADE INITIATING APPARATUS AND METHODS OF USE AND METHODS OF CLOSING WOUNDS - Wound closure methods and apparatuses are provided which utilize blood fluid by activating the clotting cascade of the blood fluid outside the body within a substantially enclosed sterile container then introducing coagulated blood to the wound site to complete clotting. Methods and apparatuses for providing ways of inhibiting anticoagulants and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed. | 07-10-2014 |
20140271909 | Methods for Segregating Particles Using an Apparatus with a Size-Discriminating Separation Element Having an Elongate Leading Edge - The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles. The breadth of the leading edge of at least one step of the apparatus is significantly greater than the overall width of the passageway in which the step occurs, permitting high and rapid sample throughput. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate circulating tumor cells from a human blood sample. | 09-18-2014 |
20140287055 | Biodegradeable Putty Compositions and Implant Devices, Methods, and Kits Relating to the Same - Disclosed are phospholipid based compositions and implant devices, as well as methods and kits that include such compositions or components thereof. In particular, the present compositions include a polymer component such as a poloxamer or PEG component and a phospholipid component, such as a Phosal. The present compositions may include at least one additional component, such as granules, powder and/or particulates. The present compositions may further include one or more bone graft materials and/or active ingredients. The compositions may be used on their own or incorporated on or in a surgical implant. | 09-25-2014 |
20140302160 | MICROFLUIDIC METHOD AND SYSTEM FOR ISOLATING PARTICLES FROM BIOLOGICAL FLUID - The invention relates to a system and method for isolating particles from a biological fluid, including: obtaining a sample of biological fluid from a source (e.g. a patient) in which the sample contains particles of multiple sample particle types; tagging particles in the sample with tagging agents, including mixing the sample with a solution of magnetic tagging agents that selectively bind to particles of at least one of the sample particle types, thereby forming a group of tagged particles in the sample; passing the sample through a magnetic conduit having a magnetic field that interacts with at least some of the tagged particles; sorting the particles of the sample into multiple groups based on the interaction between the tagged particles and the magnetic field; and optionally returning selected portions of the processed fluid back to its source with or without the addition of appropriate therapeutic agents. | 10-09-2014 |
20150079192 | Treatment of cancer by manipulating the immune system - The present invention relates to the treatment of cancers. Specifically, the invention pertains to a method for the extracorporeal treatment of one or more body fluids (e.g., blood or cerebrospinal fluid, CSF) in two stages characterized by removing a body fluid (e.g., blood or CSF) from a living body diseased with a type of cancer, passing the body fluid through a first stage of applying a treatment to at least one antigen in the body fluid. More specifically, the treatment comprises creating an antibody-antigen moiety during passage thereof through said first stage, passing the treated body fluid through a second stage, removing antibody-antigen moiety from the body fluid during passage through the second stage, and returning the purified body fluid to the body. | 03-19-2015 |
20150079193 | COMPOSITIONS AND METHODS FOR INDUCING ANGIOGENESIS - The present invention relates to compositions and methods of inducing angiogenesis and methods of treating a pathology that would benefit from angiogenesis by use of a composition comprising partially purified intact mitochondria and/or ruptured mitochondria derived therefrom. | 03-19-2015 |
20150110887 | Permselective Membrane for Treating Vascular Calcifications in Chronic Hemodialysis Patients - The present disclosure relates to a hemodialysis membrane for the treatment of vascular calcification in hemodialysis patients, especially in chronic hemodialysis patients. The present disclosure further relates to methods of treating vascular calcification in hemodialysis patients, wherein the hemodialysis membrane is characterized in that it comprises at least one hydrophobic polymer and at least one hydrophilic polymer and in that it has a MWRO of between 15 and 20 kD and a MWCO of between 170-320 kD or that the hemodialysis membrane comprises at least one hydrophobic polymer and at least one hydrophilic polymer and has a MWRO of between 8.5 kD and 14.0 kD and a MWCO of between 55 kD and 130 kD. | 04-23-2015 |
20150297793 | DEMINERALIZED BONE MATRIX WITH IMPROVED OSTEOINDUCTIVITY - Methods of making and osteoinductive compositions are provided. The method includes mixing isolated periosteum tissue with a demineralized bone matrix to form the osteoinductive composition. The periosteum tissue is isolated from the surface of large bones such as femur, tibia, humerus or a mixture thereof. The demineralized bone matrix can include a plurality of surface demineralized or fully demineralized bone fibers, bone chips, bone particles or mixtures thereof. In the osteoinductive composition the substantially isolated periosteum tissue is from about 0.5% wt. to about 10% wt. A method for repairing a bone defect is also provided. The method of treatment includes applying to the bone defect a substantially effective amount of a mixture of isolated periosteum tissue and demineralized bone matrix. | 10-22-2015 |
20150329435 | COMBINED ANIMAL REPELLANT AND FERTILIZER COMPOSITION - A composition, as a liquid or spreadable solids, combines an effective amount of a fertilizer, preferably urea and potassium sulfate or potassium chloride, and an effective amount of an animal repellant, preferably a minimum-risk pesticide product, with a liquid carrier, preferably water, or a spreadable solid carrier. | 11-19-2015 |
20150335672 | Treatment of Diseases Using Combination of Ultraviolet Blood Irradiation and Antibiotics - A method of and composition for treating a patient having | 11-26-2015 |
20150352158 | Method and preparation for accelerating fracture healing - The invention relates to medicine and can be used for accelerating the healing of bone fractures. The claimed invention is directed to solving the technical problem of accelerating fracture healing and reducing patient rehabilitation times and periods of incapacity for work. | 12-10-2015 |
20150356266 | IMMUNE AND OXYGEN SYSTEM MEASURING AND DRUG SCREENING METHOD AND APPARATUS - Method and apparatus for monitoring health as related to immune system function, and for measuring the effects of toxins and other stresses. A method for pre-screening drugs for the pharmaceutical pipeline. A method for using an Immunogram as a research tool. A method for preparing compounds or drugs for treatment, therapy, or cure of diseases. | 12-10-2015 |
20160008525 | Hyperoxygenation/Hyperthermia Treatment Apparatus | 01-14-2016 |
20160030512 | COMBINATION PREPARATION COMPRISING A CYTOKINE ANTAGONIST AND CORTICOSTEROID - The present invention relates to the treatment of patients with pharmaceutical compositions for a combination therapy with a cytokine antagonist and a corticosteroid. By means of the combination therapy diseases such as osteoarthritis, tendon injuries and/or degenerative spinal diseases can be treated. | 02-04-2016 |
20160101084 | METHODS OF TREATING DEGENERATIVE DISEASES/INJURIES - Invented is a method of treating degenerative diseases/injuries, in a mammal, including a human, in need thereof which comprises the administration of a therapeutically effective amount of a non-peptide TPO receptor agonist to such mammal. | 04-14-2016 |
20160250407 | Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases | 09-01-2016 |
20180021375 | MODIFIED BLOOD CLOTS | 01-25-2018 |