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424 - Drug, bio-affecting and body treating compositions

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Class / Patent application numberDescriptionNumber of patent applications / Date published
424529000 Blood 75
424537000 Body fluid or exudate or transudate other than snake venom, feces, urine, or semen (e.g., lymph, saliva, honey, royal jelly, digestive juice, etc.) 61
424522000 Separated animal oil or solidified form thereof derived from animal flesh and other than from liver or dairy type 53
424535000 Milk or colostrum (e.g., butter, whey, etc.) 46
424548000 Derived from musculoskeletal system, other than cardiac muscle (e.g., cartilage, muscle, etc.) 43
424572000 Tissue, other than lymphoid tissue (e.g., connective, etc.) 38
424538000 Derived from arthropod (e.g., insect, spider, crustacea, etc.) 28
424582000 Embryonic structure (e.g., embryo or fetus, etc.) 26
424550000 Digestive system (e.g., salivary gland, etc.) 16
424547000 Derived from mollusk 14
424581000 Egg enclosed in shell or a part thereof (e.g., eggshell, egg yolk, etc.) 13
424558000 Urogenital system (e.g., kidney, etc.) 6
424528000 Bile, bile acid, bile salt, amniotic fluid, or ascitic fluid 6
424577000 Hemic or immune system (e.g., hematopoietic system, bone marrow cells, etc.) 5
20110020464METHODS OF TREATMENT USING THYMUS-DERIVED COMPOSITIONS - Embodiments of the present invention provide processes for preparing thymus extracts and plant or fungal extracts, and more particularly provide compositions (Thyex-1-6A and -6B) produced in accordance with said processes, and methods for treatment of various conditions comprising administration of said compositions including but not limited to impaired physical vigor or aptitude, and aging and/or age-related conditions (arthritis, mobility deficits, loss of appetite, etc.). Additional aspects provide methods for building muscle mass, for reducing exercise recovery period, or for sustaining exercise intensity. Particular aspects relate to preparation of 01-27-2011
20110020465METHODS OF TREATMENT OF GOUT USING THYMUS-DERIVED COMPOSITIONS - Embodiments of the present invention provide processes for preparing thymus extracts and plant or fungal extracts, and more particularly provide compositions (Thyex-1-6A and -6B) produced in accordance with said processes, and methods for treatment of various conditions comprising administration of said compositions including but not limited to arthritis and/or arthritis-related conditions, including: gout, rheumatoid arthritis (RA), osteoarthritis (OA), and pseudogout, and/or inflammation resulting from any of the conditions Additional aspects provide methods for combination or adjunctive therapies (with anti-inflammatories, etc.). Methods to modulate immune response are also encompassed.01-27-2011
20090041854PARATHYROID AND THYMUS TRANSPLANTATION IN DIGEORGE SYNDROME SUBJECTS - A method of treating hypoparathyroidism in a human DiGeorge syndrome subject comprises (a) implanting thymus tissue into the subject in an amount effective to treat the DiGeorge syndrome; and (b) implanting, preferably concurrently implanting, parathyroid tissue into the subject in an amount effective to treat the hypoparathyroidism.02-12-2009
20130136799MONITORING HEALTH AND DISEASE STATUS USING CLONOTYPE PROFILES - There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using DNA sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions. Identified biomarkers can be used to determine and/or monitor the disease state for a subject with an associated lymphoid disorder or autoimmune disease or other condition. In particular, the invention provides a sensitive method for monitoring lymphoid neoplasms that undergo clonal evolutions without the need to development alternative assays for the evolved or mutated clones serving as patient-specific biomarkers.05-30-2013
20100297255MALLEABLE IMPLANTS CONTAINING DEMINERALIZED BONE MATRIX - Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions.11-25-2010
424542000 Derived from snake (e.g, venom, etc.) 5
20080279958SNAKE VENOM COMPOSITIONS AND METHODS OF USE - The invention relates to the discovery that formulations of Lachesis venom decrease circulating TNF-α levels in mammals including humans, and that administration of Lachesis venom-containing formulations to mammals suffering from sepsis, parasitic infection, cisplatin nephrotoxicity, rheumatoid arthritis, cancer and AIDS mitigates symptoms associated with these conditions.11-13-2008
20090104279USE OF PAK INHIBITOR FOR THE TREATMENT OF A JOINT DISEASE - The invention refers to the use of a p21-activated kinase (PAK) inhibitor as a target protein for the discovery of a PAK inhibitor as a medicament for the treatment of a joint disease.04-23-2009
20080254137Treatment of autoimmune disorders using detoxified cobratoxin - Autoimmune disorders are widespread diseases with many manifestations. Immune regulatory dysfunction is central to the progress of these diseases. The control this dysfunction can be achieved through intervention in the immune pathways. The balance of regulatory cytokines is central to a correctly functioning immune system and is a target for therapeutic intervention. Herein is described the induction of the regulatory cytokines, interferon gamma and interleuking 27, as a method to treat autoimmune diseases and a method by which such regulatory cytokines can be induced using a detoxified cobra neurotoxin composition.10-16-2008
20130171263Snake Powder Extract For Treatment Of Cancer - The present invention relates to a pharmaceutical composition comprising snake powder that is derived from the Tzabcan “07-04-2013
20110311642COMPOSITION AND METHOD FOR ORAL DELIVERY OF COBRA VENOM - A composition of sterile cobra venom and a method for its oral administration to provide significant analgesic effects to a human and/or animal are disclosed. Such cobra venom compositions comprise a sterilized solution preserved by the addition of one or more suitable food-grade preservatives. The venom composition may be conveniently administered orally by means of a metered spray device.12-22-2011
424543000 Waste or feces (e.g., slaughterhouse offal, chicken feet, horn, hair, hide, urine, etc.) 5
20090041853Therapeutic bio platinum complex - A novel bio platinum complex which increases the therapeutic applicability and effectiveness of platinum used as a cancer treatment in humans and animals especially in anti tumor treatments and to prevent the spread of cancer without fear of high toxicity. The present invention provides for a new method of administration of the bio platinum complex, which is oral administration in specific dosage with suitable carriers either by itself or in combination with other metals or minerals. The administration of the novel bio platinum complex can be carried out in combination with other plant materials depending on the nature of the treatment afforded. Use of the novel bio Platinum complex extends to agriculture and horticulture. Further, the invention is characterized by the irreversible nature of the bio platinum to its metallic form, high solubility, and the non-toxic nature when used in specific dosage, which increases the utility of platinum, in various other fields apart from its therapeutic applications. The present invention also provides for a new process for the preparation of bio platinum with the aid of plant materials.02-12-2009
20100260862TIME RELEASE FORMULATIONS AND METHODS OF MAKING SAME - Time release repellent formulations and methods of making formulations, comprising a natural repellent, alum in an amount effective to keep microbial count below a pre-determined level and a natural binder. The natural repellent may be animal urine or a natural oil. The natural binder is selected from the group consisting of: rice, pearlite, polymer, peat moss, clay and foam. The pH level of the formulation is maintained within a pre-determined range by adding a natural acid to lower the pH level or adding a natural base to raise the pH level.10-14-2010
20130045280PRODUCT AND TREATMENT FOR HEPATITIS C AND SCLEROSIS OF THE LIVER AND METHODS OF FORMING THE PRODUCT - A method for formulating a treatment for hepatitis C and sclerosis of the liver is disclosed. The method may comprise steps of processing bone marrow of a bone of a bird. To prepare the composition for feeding to a mammal, the mammal is prepared by purging the mammal's intestines of fecal matter. After purging the mammal's intestines of fecal matter, the processed bird bone is fed to the mammal. The mammal's feces is then collected and mixed with crushed pumpkin seed.02-21-2013
20120107409PREPARATION AND USE OF FISH SKIN FERMENTATION PRODUCT - The present invention relates to a method for fermenting fish skin by using 05-03-2012
20080317867Cosmetic System, and Method for Disguising Skin Defects - The present invention provides a cosmetic system for disguising dermatological blemishes. The cosmetic system includes a viscous silicone material and a catalyst. The silicone material is pigmented with a cosmetic pigment according to a selected skin tone. In one aspect, the cosmetic system also includes a flocking agent. The flocking agent is mixed within the silicone material or the catalyst to provide texture. The cosmetic system also includes at least two cartridges. The cartridges hold the viscous silicone material and the catalyst, separately. Optionally, the cosmetic system includes a dispensing gun. The dispensing gun has a tip through which the silicone material and the catalyst may be dispensed, whereupon the silicone material and the catalyst are mixed and applied to a user's skin for curing. A method for disguising dermatological blemishes is also provided herein.12-25-2008
424569000 Cardiovascular system, other than umbilical artery or vein (e.g., blood vessel, heart, cardiac muscle, etc.) 3
20090028959PHARMACEUTICAL COMPOSITION AND METHOD FOR REGENERATING MYOFIBERS IN THE TREATMENT OF MUSCLE INJURIES - A pharmaceutical composition and method for regenerating cardiomyocytes in treating or repairing heart muscle damages or injuries caused by an ischemic disease. The pharmaceutical composition contains an active ingredient compound with a backbone structure of Formula (I). The active ingredient compound is capable of (a) increasing viability of myogenic precursor cells to enable said precursor cells to survive through an absolute ischemic period; (b) reconstituting a damaged blood supply network in said heart region where said injured muscle is located; and (c) enhancing cardiomyogenic differentiation efficiency of said precursor cells down cardiac linage, said steps being performed simultaneously or in any particular order.01-29-2009
20080305181Compositions and Methods for Treatment of Vascular Grafts - The present invention contemplates compositions and methods for the treatment of vascular grafts both ex vivo and in vivo. Ex vivo treatment comprises completely removing a vessel (i.e., vein or artery) from the body and treating with the compositions of the present invention. In vivo treatment comprises treating the vessel in vivo without removing the vessel completely from the body (albeit one or both ends of the vessel may be closed off in order to focus the treatment in the desired area and/or avoid systemic treatment). In one embodiment, at least a portion of the smooth muscle cells of a vessel (e.g., vein or artery) are transfected ex vivo or in vivo with a vector capable of expressing at least one phosphatase. In a preferred embodiment, smooth muscle cells are transfected with adenovirus vector comprising the gene encoding PTEN.12-11-2008
20130156862Extracellular Matrix-Derived Gels and Related Methods - Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.06-20-2013
424557000 Respiratory system (e.g., lung, etc.) 2
20080260854Sirna Molecules for the Treatment of Blood Vessels - The present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic construct and/or the siRNA molecules and can be used for inhibition of the expression of endothelial adhesion molecules. The invention also relates to a device, which is coated with the aforementioned molecules, the composition or the construct, or contains them. The present invention further relates to a corresponding use of the nucleic acid molecule, of the genetic construct or of the siRNA molecules and a method of inhibition of the expression of adhesion molecules and a method of vessel grafting, lung transplantation, treatment of lung transplants, and a method of treatment of the open heart within the scope of cardioplegia.10-23-2008
20080305180Method of administration of a pulmonary surfactant - The present invention concerns a method for treating a respiratory distress in a infant in need of such treatment, the method comprising intratracheal administration of a pulmonary surfactant by a thin tube.12-11-2008
424562000 Endocrine system, other than the thymus gland (e.g., parathyroid gland, etc.) 2
20110206775Preparation of inert pharmaceutical excipients for stabilizing unstable pharmaceutical ingredients - In a method of treating a pharmaceutical component, a reducing substance is added to a solution of water and a pharmaceutical excipient having at least one residual reactive impurity. The reducing substance is allowed to react with the residual reactive impurity, thereby generating an inert reaction product. The any remaining amount of the reducing substance is removed from the pharmaceutical excipient. The pharmaceutical excipient is dried after the removing step.08-25-2011
20100080854Atopic dermatitis inducer - An atopic dermatitis inducer binding to a human own IgE antibody and activating mast cells and basophiles, which includes a purified human secretion fraction, or an antigenic molecule or an antigenic determinant in the purified fraction, and obtained through the following steps of: filtering a human secretion, removing insoluble matters and collecting the filtrate; mixing the filtrate with a ConA-affinity carrier and collecting the supernatant; and separating a component having a histamine-releasing activity from the supernatant by column chromatography. This inducer is effective in diagnosing and treating human atopic dermatitis.04-01-2010
424571000 Sense organ (e.g., eye, taste bud, etc.) 1
20130209571BIOENGINEERED HUMAN CORNEAL STROMAL TISSUE - Provided herein is a method of making an aligned ECM scaffold useful in refractive correction of the eye and repair of the cornea. Methods of use of the scaffold as well as a scaffold construct are provided.08-15-2013
20120183624METHOD FOR MANUFACTURING HOMEOPATHIC PERSONAL CARE PRODUCTS - A method for making a personal care composition including homeopathic remedies and essential oils. The homeopathic remedies are selected from one or more pharmacopeias wherein the remedies are indicated for one or more biological conditions. Remedies are selected because they are indicated for the same disease condition or in certain embodiments related conditions. Once selected the remedies are diluted to a predetermined concentration and blended with essential oils. In certain embodiments a medicated cleansing bar, a soap, or a cleansing material may be selected for delivering the homeopathic remedy and the essential oils. The essential oils may be extracted from plant material using various techniques including distillation.07-19-2012
20090238892DEER ANTLER EXTRACT FOR PROMOTING ANGIOGENESIS - An isolated extract of deer velvet which contains components which have molecular weights that are substantially are less than or equal to 10 kDa and which have a proliferative effect on endothelial cells and/or promote angiogenesis.09-24-2009
20100119613PROCESS TO ACTIVATE EXTRACTS DERIVED FROM LIVING ORGANISMS USING LONG WAVE UV IRRADIATION AND COMPOSITIONS COMPRISING SAID ACTIVATED EXTRACT - The present invention relates to a method for producing an extract which is capable of inducing an antioxidant stress response comprising the step of treating an extract from organic material with UV light, said extract being derived from a non-mammalian cell or a non-mammalian organism and said cell or organism being capable of synthesizing polyunsaturated fatty acids. Furthermore, an extract capable of inducing an antioxidant stress response produced in accordance with the inventive methods, in particular an extract capable of inducing an antioxidant stress response for the preparation of a cosmetic composition is disclosed. The present invention also relates to a cosmetic composition comprising the inventive extract obtainable by the method provided herein.05-13-2010
20100074962DEGRADATION OF PRION PROTEIN AND REDUCED PRION INFECTIVITY BY EARTHWORM HOMOGENATES - Methods for the degradation of prion proteins are described. Items that may be contaminated with prions are treated with earthworm-derived extracts to degrade prion proteins and reduce their infectivity in animals. Methods of using an earthworm-derived protein extract for treating foodstuffs and surfaces to inhibit or disable prion infectivity are disclosed. Also disclosed are methods for treating medical instruments, tools used to butcher animals, and laboratory equipment.03-25-2010
20100323027MESENCHYMAL STEM CELL CONDITIONED MEDIUM - We disclose a method of preparing a conditioned cell culture medium, the method comprising the steps of: (a) culturing a mesenchymal stem cell (MSC), a descendent thereof or a cell line derived therefrom in a cell culture medium; and (b) optionally isolating the cell culture medium; in which the mesenchymal stem cell (MSC) is obtained by propagating a cell obtained by dispersing a embryonic stem (ES) cell colony, or a descendent thereof, in the absence of co-culture in a serum free medium comprising FGF2.12-23-2010
20110003008MESENCHYMAL STEM CELL PARTICLES - We describe a particle secreted by a mesenchymal stem cell and comprising at least one biological property of a mesenchymal stem cell. The biological property may comprise a biological activity of a mesenchymal stem cell conditioned medium (MSC-CM) such as cardioprotection or reduction of infarct size. The particle may comprise a vesicle or an exosome.01-06-2011
20090269415NOVEL THERAPEUTIC AGENT DERIVED FROM MARINE ORGANISM - There is provided a nerve repairing agent, anti-ulcer agent or the like comprising an extract from a marine organism selected from organisms belonging to the class Holothuroidea, the phylum Porifera and the order Actiniaria or a material removed from a viscus of the organism. The extract has the following properties (1) to (4): (1) it is a almost colorless, transparent and viscous liquid having a slight fishy smell, or a almost white powder having a slight fishy smell which, when dissolved in water, is almost colorless and viscous; (2) a solution prepared by dissolving the liquid or powder in water shows the maximum absorbance at a wavelength of 264±10 nm; (3) a solution prepared by dissolving the liquid or powder in water shows an acidic pH value; and (4) it has at least one effect selected from a cranial nerve repairing effect, a nerve-growing effect, an insulin-releasing effect, an immunopotentiating effect, a noxious pain preventive effect, a neurogenic pain preventive effect, a diabetic sensory neuropathy ameliorating effect and an ulcer preventive effect.10-29-2009
20110020460GPR 119 MODULATORS - Compounds of Formula I that modulate the activity of the G-protein-coupled receptor GPR119 and their uses in the treatment of diseases linked to the modulation of the G-protein-coupled receptor GPR119 in animals are described herein.01-27-2011
20110020459Microfluidic method and system for isolating particles from biological fluid - The invention relates to a system and method for isolating particles from a biological fluid, including: obtaining a sample of biological fluid from a source (e.g. a patient) in which the sample contains particles of multiple sample particle types; tagging particles in the sample with tagging agents, including mixing the sample with a solution of magnetic tagging agents that selectively bind to particles of at least one of the sample particle types, thereby forming a group of tagged particles in the sample; passing the sample through a magnetic conduit having a magnetic field that interacts with at least some of the tagged particles; sorting the particles of the sample into multiple groups based on the interaction between the tagged particles and the magnetic field; and optionally returning selected portions of the processed fluid back to its source with or without the addition of appropriate therapeutic agents.01-27-2011
20090238891Method of producing a dry earthworm powder - Provided is a method of producing a dry earthworm powder without deterioration in useful pharmacological action, by removing dirt on the skin of earthworms while allowing the earthworms to excrete the digest remaining in the digestive tracts efficiently without weakening the earthworms, which comprises the steps of: standing living earthworms under light for 10 to 50 hours, removing the dirt formed on the skin thereof, adding an organic acid to the living earthworms, diluting the acid rapidly with addition of water, adjusting the pH of the aqueous acidic solution to 2 to 5, standing the earthworm mixture for 3 to 180 minutes under the pH condition, washing the earthworms with water, grinding the earthworms into a homogenate, freezing the homogenate at −18° C to −35°0 C, keeping the frozen homogenate for 20 to 240 hours, and freeze-drying and degassing the frozen homogenate under vacuum simultaneously.09-24-2009
20090011041Compositions for Correcting Age Related Changes of a Human Endocrine System and Methods for Producing a Pharmaceutical Form Bases on Said Compositions - The present invention relates to anti-aging pharmacology and is intended for correction of age-related changes in human endocrine system. The essence of the invention is the compositions for correction of certain age-related endocrine changes and method for production of pharmaceutical form based thereon. Each composition contains a mixture of substances exhibiting hormonal activity (HA) or hormone-like activity (HLA) selected from the group: C21 or C19 steroids, pregnenolone, 17-hydroxypregnenolone, DHEA, progesterone, testosterone, or a hormone-like substance of herbal origin (HS), and also a dry methanolic of Nettle root extract, taken in a definite ratio, wherein HA, HLA or HS with the Nettle root extract can further contain a Deer Antler velvet extract and/or Ginseng root extract, and HS can comprise diosgenin or protodioscin. One variant of the composition is a mixture of a dry Ginseng root extract and a dry Nettle root extract. The inventive method for production of said pharmaceutical form consists in mixing an active component and pharmaceutically acceptable carrier with suitable adjuvants in an effective amount. The useful result is in broadening the range of natural agents able to correct age-related hormonal changes in human organism.01-08-2009
20120237607Immortalized cell compositions and compositions derived therefrom - The invention is directed to immortalized cell compositions and compositions derived therefrom. The invention is further directed to methods of making and using such immortalized cell compositions and compositions derived therefrom. Such immortalized cell compositions include but are not limited to Immortalized Amnion-derived Multipotent Progenitor cells (herein referred to as I-AMP cells) and conditioned media derived therefrom (herein referred to as I-Amnion-derived Cellular Cytokine Solution or I-ACCS).09-20-2012
20110236499DERMAL COMPOSITIONS CONTAINING GORGONIAN EXTRACT - A skincare composition comprising Gorgonian extract as an anti-inflammatory component thereof, said skincare composition being selected from among compositions (I) and (II): (I) an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.% surfactant, from 0.01 to 0.2 wt.% retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt. %; and (II) a gel composition comprising from 60 to 90 wt.% water, from 1 to 12 wt.% benzoyl peroxide, and from 0.05 to 1.25 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.09-29-2011
20110142953COMBINATIONS OF IMMUNOSUPPRESSIVE AGENTS FOR THE TREATMENT OR PREVENTION OF GRAFT REJECTIONS - A pharmaceutical composition useful in the treatment or prevention of transgenic xenograft rejection comprising immunosuppressant compounds selected from the group consisting of an IL-2 transcription inhibitor and immunosuppressant compounds that immunosuppress for B-cell-mediated or antibody-mediated rejection of xenografts, and pharmaceutically acceptable diluents or carriers, and a method of preventing hyperacute rejection, reducing early graft damage, improving early xenograft function and promoting long term survival of said transgenic xenografts comprising the steps of i) contacting the body fluid removed from a human recipient with a xenoantigenic material which is bound to a biocompatible solid support, ii) reintroducing the treated body fluid into the recipient, and iii) treating the recipient with said pharmaceutical composition.06-16-2011
20110280950SYNERGISTIC ANTIOXIDANT COMPOSITIONS - Antioxidant compositions for the stabilization of fat sources against oxidation, stabilized fat source compositions, and methods of stabilizing fat sources against oxidation are described. In particular, an antioxidant emulsion that includes quercetin in addition to at least one other ingredient and a lipid carrier is described.11-17-2011
20090087495Food for Improving Motor Function - A food for improving motor function comprising as effective components carnosine and/or anserine and a material for improving motor performance (a material for motor energy source, a material for promoting conversion into energy and/or an antioxidant) is provided. In the invention, by synergistic effect of these components, the motor function or stamina can be improved and recovery from fatigue can be promoted in humans and mammals. Further, any of the effective components of the food for improving motor function of the invention is a naturally occurring component, therefore, the food has a characteristic of high safety.04-02-2009
20100034897Method for Removal or Inactivation of Heparin - The present invention relates to the use of immobilized RAGE or portions thereof for removal of heparin and low molecular weight heparin from a fluid sample or from a patient in need of neutralization of anticoagulant activity. The invention provides a method for removal or inactivation of heparin and low molecular weight heparin, as well as a device which utilizes this method.02-11-2010
20090148536Traditional chinese medicine composition to treat rheumatoid arthritis and Preparation method thereof - The present invention discloses a traditional Chinese medicine composition to treat Rheumatoid Arthritis and its preparation method. The composition is mainly comprised of the following crude drugs: ant, Radix Salviae Miltiorrhizae, Radix Aconiti Preparata, Radix Ginseng, Caulis Spatholobi, and Ramulus Cinnamomi, etc. According to pharmaceutical methods, various clinical acceptable dosage forms can be prepared of the composition of the present invention, including but not limited to one of the following dosage forms: tablets, capsules, pills, granules, suspension, dripping pills, oral liquid preparation, etc. The drug of the present invention has the functions of invigorating the kidney and spleen, promoting blood flow and clearing out the vein, expelling wind-evil and removing wetness, eliminating cold to stop pain. It can be effectively used in the treatment of lingering arthralgia with weak, arthralgia, intumesce and morning stiffness, numbness and stickiness, difficult to flex and extend, rigor and deforming, the rheumatism and rheumatoid arthritis with the above symptoms.06-11-2009
20100203154Elasmobranch-Repelling Compounds, Methods of Use and Devices - Elasmobranch-repelling compositions are prepared from elasmobranch carcasses. Extraction of these elasmobranch carcasses with polar solvent after a period of aerobic decay yields semiochemical repellents that induce a flight reaction in sharks when introduced into the sharks' oceanic proximity.08-12-2010
20120294949METHODS OF PRODUCING STEM CELL CONDITIONED MEDIA TO TREAT MAMMALIAN INJURIES OR INSULTS - Methods of producing stem cell conditioned media to treat mammalian injuries or insults. In at least one embodiment of a method of producing a stem cell conditioned media of the present disclosure, the method comprises the steps of culturing at least one stem cell in a first cell culture medium, replacing some or all of the first cell culture medium with a second cell culture medium and further culturing the at least one stem cell in the second cell culture medium, and collecting a quantity of the second cell culture medium after a culture duration, wherein the quantity of the second cell culture medium contains a cell culture byproduct effective to treat a mammalian insult or injury. In another embodiment, the step of culturing comprises culturing the at least one stem cell in EGM2MV.11-22-2012
20090162452EB Matrix Production From Animal Tissue And Its Use For Tissue Repair - A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue to chemical and mechanical processing. In addition to skin tissue, another source of EBM is a blood vessel. EBM may be used for hernia repair, colon, rectal, vaginal and or urethral prolapse treatment; pelvic floor reconstruction; muscle flap reinforcement; lung tissue support; rotator cuff repair or replacement; periosteum replacement; dura repair; pericardial membrane repair; soft tissue augmentation; intervertebral disk repair; and periodontal repair. EBM may also be used as a urethral sling, laminectomy barrier or spinal fusion device.06-25-2009
20100124573EXTRACELLULAR MATRIX COMPOSITIONS FOR THE TREATMENT OF CANCER - The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.05-20-2010
20080206352Extract for Preventing or Treating Thrombotic Diseases - An extract for preventing or treating thrombotic disease, particularly, an extract of leech and/or earthworm with molecular weight of not more than 5800 Dalton, and processes for preparation, pharmaceutical compositions and uses thereof. The extract of the present invention has improved significantly safety without any reducing in pharmaceutical activities or the therapeutical effects as compared to existing products.08-28-2008
20110076338Composition for Skin Protection and Methods of Making Same - Skin care formulations having tamanu oil in amounts providing effective rates of protection for antimicrobial and anti-aging properties, including but not limited to promoting the formation of new tissue, scar healing and skin repair, anti-inflammatory, anti-bacterial, anti-fungal, anti-oxidant, and combinations thereof.03-31-2011
20120294950METHOD FOR PRODUCING DRY EARTHWORM POWDER - A method for producing dry earthworm powder, by which dry earthworm powder having high-titer enzymes can be produced while removing toxic substances contained in the bodies of earthworms, is provided. The method comprises: 11-22-2012
20090202653Compositions and method for enhancing proteoglycan production - The present invention provides compositions comprising notochord enriched media and/or one or more factors derived therefrom. Such compositions are useful for enhancing the production of proteoglycan in cells or animals in need thereof, for example for treating degenerative disc disease. The notochord enriched media is preferably obtained from a nonchondrodystrophic animal.08-13-2009
20100015242USE OF A COMPOSITION FOR SKIN TREATMENT UNDER X-IRRADIATION - The invention relates to the use of a composition in the production of a dermatological agent for skin treatment under repeated X-irradiation. The composition includes oxygen-bearing asymmetrical lamellar aggregates of phospholipids and fluorocarbons as well as specific water-soluble antioxidants, said composition having a radical protection factor of at least 4000×1001-21-2010
20100260861TREATMENTS WITH HELMINTHS - The invention relates to a method of treating obesity or IBS in an individual by administering a physiologically acceptable composition comprising a helminthic parasite, or an active variant thereof, that is of a type and present in an amount sufficient to treat the individual for obesity or IBS. The invention is not limited to obesity and IBS and is further drawn to conditions of health in which the microbiota profile for a population of microbes found within an individual contributes to a pathological condition.10-14-2010
20100183733HAIR GROWTH-INHIBITING AGENT - A hair removing agent or a hair growth inhibiting agent is provided by determining an endogenous factor having a hair growth inhibitory activity, screening for substances having an activity similar to that of the endogenous factor or substances enhancing the activity or expression of the endogenous factor, and utilizing the physiological activities of such substances. It has been found that FGF18 inhibits hair growth. A method of screening for FGF18-like active substances, substances that promote the activity of FGF18 or substances that promote the expression of FGF18 to thereby obtain candidates for the hair growth inhibiting agent or hair removing agent is disclosed. Also disclosed is a hair growth inhibiting agent or a hair removing agent comprising, as an active ingredient, FGF18 and/or an FGF18 partial peptide, or an FGF18-like active substance and/or a substance that promotes the activity or expression of FGF18 (e.g., Digenea simplex extract).07-22-2010
20100255113HERBAL COMPOSITION FOR TREATMENT OF NEURODEGENERATION AND NEURONAL DYSFUNCTION - This invention provides methods of using various herbal compositions to treat neurodegenerative diseases and neuronal dysfunctions, said compositions comprise a combination of Radix 10-07-2010
20110123638METHOD FOR THE INTRADERMAL DELIVERY OF SUBSTANCES - This invention describes method to facilitate intradermal delivery of a great variety of active substances, especially including high molecular weight cosmicuticals. Also disclosed is a method of applying the composition of matter resulting from the method topically to patients, especially using a cream or patch. The active substance is initially combined with a biopolymer, which combination is subsequently linked to a base formulation whereby the base formulation aids in the intra-dermal delivery of the active substance without the skin irritation limitations of other formulations and dermal transmitting methods. The method of using a combination of natural herbal, vegetable and animal products combined in this invention with biopolymers permits molecules of higher molecule weight to penetrate into the skin in a bioactive form by passive delivery means. The invention includes a method for the improvement of skin health and wrinkle reduction.05-26-2011
20090068281Composition, Functional Food and Pharmaceutical Composition for Improvement in Obesity - A composition for improving obesity is disclosed. The composition contains a natural ingredient free of side effects in daily intake as an active ingredient. The composition is capable of remarkably reducing body fat, as compared with a conventional ingredient which is derived from a natural ingredient as an active ingredient, and is capable of suppressing fat storage. The composition includes a meat extract or a fish meat extract, and a fat storage suppressive substance.03-12-2009
20110111046N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors - The invention provides a compound of Formula (I)05-12-2011
20100015241AVIAN-BASED INSECT REPELLENT - The invention provides an insect repellent that repels flies, gnats, mosquitoes, lice, ticks, and fleas. The insect repellent comprises an avian-based extract, in particular an extract isolated from birds of the order Psittaciformes (parrots). The invention also provides an insect repellent composition about 5 volume% to about 75 volume % of the avian-based extract and about 95 volume % to about 25 volume % of a carrier vehicle.01-21-2010
20110086105METHODS FOR IDENTIFYING NOVEL NUCLEIC ACID REGULATORY ELEMENTS AND COMPOUNDS THAT AFFECT THE REGULATION - Described herein are methods for identifying novel nucleic acid regulatory elements and compounds that modulate the regulation of such elements. Also described herein are nucleic acid sequence identified as novel nucleic acid regulatory elements and host cells containing such nucleic acid regulatory elements in a vector.04-14-2011
20110086106METHOD OF PRODUCING A DRY EARTHWORM POWDER - Provided is a simple and easy method of producing an innoxious dry earthworm powder, while suppressing inactivation of the enzymes contained in earthworms. In the method, a homogenate obtained by grinding living earthworms is freeze-dried and the dried product is heat-treated at a temperature of 110° C. or higher but lower than 130° C. Preferably, the method according to the present invention comprises further a process for preparation of the living earthworms, which precedes the grinding step, comprising the steps of: standing the living earthworms under light for 10 to 50 hours; removing the dirt formed on the skin thereof, bringing the earthworms into contact with an organic acid for 30 seconds or less; diluting the acid with addition of water to adjust the pH of the aqueous acidic solution to a pH in the range of 2 to 5; standing the earthworm mixture under the pH condition for 3 to 180 minutes; and then washing the earthworms with water.04-14-2011
20090317482METHODS AND COMPOSITIONS FOR TREATING CONGESTIVE HEART FAILURE - Compositions and methods for treating congestive heart failure are provided herein.12-24-2009
20080241269Methods of Applying Antimicrobial Formulations on Food - Methods for applying antimicrobials or other active agents onto food products, and particularly meat products, are described. The methods apply a controlled amount of treatment composition to the food product in an efficient fashion so that an excess of the solution is not required.10-02-2008
20110256232ANTIMICROBIAL COMPOSITION FROM COPEPODS - The present invention relates to an antimicrobial composition, and to a process for the preparation of such a composition. The invention also relates to the use of such an antimicrobial composition. The present invention further relates to the use of the antimicrobial composition as a pharmaceutical.10-20-2011
20120308664AVIAN-BASED INSECT REPELLENT - The invention provides an insect repellent that repels flies, gnats, mosquitoes, lice, ticks, and fleas. The insect repellent comprises an avian-based extract, in particular an extract isolated from birds of the order Psittaciformes (parrots). The invention also provides an insect repellent composition about 5 volume % to about 75 volume % of the avian-based extract and about 95 volume % to about 25 volume % of a carrier vehicle.12-06-2012
20100080853Use of Spongilla Spicules as a Dermabrasion Device or Resurfacing Modality - Dermabrasive compositions for skin resurfacing are disclosed. Therapeutic compositions disclosed are derived from Porifera species, specifically sponges, and more specifically fresh water sponges. One disclosed embodiment is derived from 04-01-2010
20090104278FOOD COMPOSITION FOR RECOVERY FROM FATIGUE - In the present application are disclosed a food composition for recovery from fatigue, comprising, as an effective ingredient, an extract of migratory fish such as a 04-23-2009
20100221358Synthetic derivatives beta glycolipids and compositions thereof for the treatment of pathologic disorders - The invention relates to novel synthetic derivatives of β-glycolipids and uses thereof as immunomodulators. More particularly, the invention relates to synthetic derivatives of β-glycolipids, specifically, the compounds of any one of Formula I, II III and IV or any mixture or combination thereof, and particularly the ALIB-97 (Formula II) derivative and uses thereof for the treatment of different pathologic disorders, particularly, immune-related hepatic disorders and pathologies associated with the metabolic syndrome.09-02-2010
20110081423Tissue Stabilization for Heart Failure - Methods and devices for the stabilization of heart tissue to treat congestive heart failure using a therapeutic composition are discussed. The therapeutic composition can comprise an elastin stabilization agent, a collagen stabilization agent, or a combination thereof and be applied to the pericardium, to the outer surface of the myocardium, or a combination thereof using a catheter type of device with an attached reservoir. Controlled placement and release of the therapeutic composition can be achieved using a delivery vehicle to formulate the composition.04-07-2011
20110111045Pharmaceutical composition for preventing and treating cell proliferative disease comprising mixture of feather of birds and scale of fish as an active ingredient - The present invention relates to a pharmaceutical composition for preventing and treating cell proliferative diseases comprising a feather of birds and a scale of fish, a scale transformed from the dermis, a degenerated or cornified variant of a scale, or a scale or horny scale of reptiles as an active ingredient. More particularly, the present invention relates to a pharmaceutical composition for preventing and treating cell proliferative diseases comprising a mixture of 70-85 weight % of a feather of birds and 15-30 weight % of a scale of fish, a scale transformed from the dermis, a degenerated or cornified variant of a scale, or a scale or horny scale of reptiles as an active ingredient. The inventive composition has the effect of inhibiting and preventing growth of cancer cells. Accordingly, the inventive composition may be used for anticancer purposes to prevent, ameliorate or treat cancer.05-12-2011
20110064822BIOMATERIAL AND PREPARATION METHOD THEREOF - A biomaterial prepared from a process comprising dehydrating the fish scales until the fish scales containing less than about 50% of water, and grinding the dehydrated fish scales into ground particles each having an average size of less than about 10,000 μm in diameter, wherein the ground particles contain a mixture of sponge like matrix and powder is provided. The invention also provides a biomaterial prepared from fish scales by a process comprising subjecting the fish scales to a heat treatment at a temperature of less than about 200° C.03-17-2011
20120009269RANGE OF ASEPTICALLY PRODUCED INFANT FOODS HAVING LOW CONCENTRATIONS OF UNDESIRED BY-PRODUCTS AND METHODS FOR MAKING THE SAME - A range of infant food products wherein each product in the range includes minimal levels of undesired by-products produced during processing as indicated by less than about 15 micrograms furan per kg food product.01-12-2012
20120121719METHODS OF MAKING AND USING THREE-DIMENSIONAL EXTRACELLULAR MATRICES - Three-dimensional extracellular matrices lacking synthetic scaffolds are provided. Methods of making the three-dimensional extracellular matrices and methods of using the three-dimensional extracellular matrices are also provided.05-17-2012
20110091569ECHINODERM-DERIVED EXTRACTS, METHODS OF PREPARATION AND USES THEREOF - An Echinozoa tissue or organ extract comprising antioxidant compounds is disclosed. Also disclosed is a process for obtaining an Echinozoa tissue or organ extract, as well an extract obtained by this process. Compositions comprising such an extract are also described. Uses of such extracts/compositions, as well as corresponding methods of treatment, for example as an antioxidant or to decrease or inhibit oxidative stress in a cell, tissue or subject are also described.04-21-2011
20110091568MEDIA CONDITIONED BY STEM CELLS AND USES THEREFOR - Compositions for application to the skin of individuals in need thereof are provided that include media conditioned by the growth of human stem cells, particularly human neural stem cells. In some embodiments, the stem cells are grown without the use of feeder layers.04-21-2011
20110091567TISSUE ORGANIZING STRUCTURE AND THERAPEUTIC METHODS - A novel cellular component, tissue organizing structure, and methods for use in detection, diagnosis and treatment of disease is described herein. Particularly, clinical applications include tissue generation from individual cellular components, gene transfer therapeutics and its use as a novel target for cancer prevention and therapeutics. More particularly, methods for disease and cancer prevention, detection, diagnosis and treatment are provided.04-21-2011
20120219632METHODS FOR MONITORING CELLULAR STATES AND FOR IMMORTALIZING MESENCHYMAL STEM CELL - We describe a method of monitoring the state of a cell, the method comprising establishing, for a selected microRNA (miRNA) species secreted by the cell, a ratio of: (a) a precursor form of the miRNA species (pre-miRNA); to (b) a mature form of the miRNA species (mature miRNA); in which the pre- to mature miRNA ratio so established is indicative of the state of the cell. We also describe a method comprising the steps of: (a) providing a mesenchymal stem cell (MSC); and (b) introducing an oncogene into the mesenchymal stem cell to thereby transform it; in which the transformed mesenchymal stem cell does not secrete a gene product of the oncogene into a medium in which it is grown.08-30-2012
20120171298USE OF PHARMACEUTICAL COMPOSITIONS IN PREPARING PHARMACEUTICALS FOR TREATING DIABETIC ULCER - The use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer in limb or on body surface, or in preparing medical dressing. The pharmaceutical compositions consist of (A) 3 to 15% by weight of edible beeswax and (B) 85 to 97% by weight of sesame oil extract of 07-05-2012
20100047360Use Of Polyamines In The Treatment Of Psoriasis - The present invention provides unbranched aliphatic polyamines for use in therapy, particularly for use in the treatment of psoriasis and compositions containing polyamines.02-25-2010
20100285145GPR 119 MODULATORS - Compounds of Formula (I) that modulate the activity of the G-protein-coupled receptor GPR119 and their uses in the treatment of diseases linked to the modulation of the G-protein-coupled receptor GPR119 in animals are described herein.11-11-2010
20090061013METHODS OF ENHANCING THE QUALITY, NUTRITIVE AND HEALTH VALUES OF MEAT FROM BOVINE - The present invention relates to methods of increasing the selenium content in beef by feeding special enriched diets, methods of improving human immune function, such as providing anticancer benefits. The present invention further provides methods for improving the quality of beef meat through a special enhanced diet, wherein organic selenium, copper, zinc and manganese replace all inorganic and metallic forms.03-05-2009
20090061012Shark Repelling Method and Repellent Incorporating Wax - A method of repelling sharks for limiting their attacking a surfboard user comprises applying a conventional surfboard traction improving solid wax that also incorporates a shark repellent such as a surfactant, a capsaicinoid or a semiochemical in a concentration based on the “Johnson & Baldridge Test”. The extent of application is consequently sufficient to render the coated surfboard foul tasting when bitten by a shark but insufficient to reliably repel a shark in response to the dispersion in the water of the repellent. The invention extends to a shark repellent incorporating surfboard coating wax.03-05-2009
20110045098EXCITATORY GLYCINE RECEPTORS AND METHODS - The invention provides isolated N-methyl-D-aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also provided are excitatory glycine receptors, containing either NR3B or NR3A polypeptides. Further provided are methods for detecting excitatory glycine receptor ligands, agonists and antagonists. The invention also provides related diagnostic and therapeutic methods.02-24-2011
20130129831Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.05-23-2013
20110217385Method for extracting mesenchymal stem cell from human or animal embryo and for extracting the secretion product thereof - The present invention relates to a method of extracting mesenchymal stem cells from human or animal embryo, comprising: A. taking the sample based on human or animal embryo, centrifuging the sample; B. digesting the sample with enzyme digestion solution, and making single cell suspension, wherein said enzyme digestion solution comprises trysin-EDTA and collagenase IV; C. adding mesenchymal stem cell culture medium A to the isolated single cells, inoculating and culturing the cells; D. treating the cells with adherence purification, and obtaining mesenchymal stem cells by magnetic sorting. The present invention also relates to a method of extracting the secretion product from mesenchymal stem cells, the use of the secretion product in the aspects of cosmetic and healthcare, and an epidermal cell repairing lotion made using the secretion product. In the process according to the present invention of extracting mesenchymal stem cells from human or animal embryo, the mixture of trypsin-EDTA and collagenase IV is used as the enzyme digestion solution, enabling to obtain the maximal number of single cells, while reducing cell damage to the lowest level.09-08-2011
20130149387BIODEGRADABLE TISSUE COMPOSITION WITH BIODEGRADABLE CROSS-LINKERS - Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described. Also described are the methods and compositions wherein the tissue is fixed using biodegradable crosslinkers. Methods and compositions for making radio-opaque tissue are also described. Methods and compositions to obtain a degradable implantable tissue-synthetic biodegradable polymer composite are also described. Compositions and methods of incorporating substantially water-insoluble bioactive compounds in the implantable tissue are also disclosed. The use of membrane-like implantable tissue to make an implantable drug delivery patch are also disclosed. Also described are the compositions and methods to obtain a coated implantable tissue. Medical applications implantable tissue such as heart valve bioprosthesis, vascular grafts, meniscus implant, drug delivery patch are also disclosed.06-13-2013
20130149386CD36 AS BIOMARKER FOR STEATOSIS - A method is provided for early treatment of steatosis, which method is based on early detection of steatosis based on the detection of CD36. CD36 is determined in a body fluid, and CD36 levels above a predetermined value is indicative of steatosis.06-13-2013
20120282344FORMULATION FOR THE BIOLOGICAL CONTROL OF INSECT-PESTS - A formulation for the biological control of pests comprises a cohort of infective juvenile insect-parasitic nematodes from at least three species, wherein at least two of the species are of a first genus, and at least one of the species is from a second genus, and the species number from the first genus is greater than the species number from the second genus. The cohort of nematodes consists essentially of two species from the first genus and one species from the second genus and comprises at least one ambusher foraging species of nematode from a first genera and at least two cruiser foraging species of nematode from a different genera, or at least two ambusher foraging species of nematode from the same genera and at least one cruiser foraging species of nematode from a different genera. The first and second genus are selected from the group comprising: Steinernematidae and Heterorhapditidae.11-08-2012
20110280951COMPOSITION FROM SPHAERANTHUS INDICUS AND GARCINIA MANGOSTANA FOR THE CONTROL OF METABOLIC SYNDROME - The invention relates pharmaceutical/dietary supplement/food ingredient(s) selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from 11-17-2011