Entries |
Document | Title | Date |
20080206314 | Transdermal Delivery Systems - Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided. | 08-28-2008 |
20080206315 | Drug containing adhesive preparation - The present invention aims at providing an adhesive preparation wherein a drug is sufficiently dissolved in an adhesive layer and is not easily separated from the adhesive layer even during preservation of the adhesive preparation. | 08-28-2008 |
20080226697 | Patch for External Use with Elevated Content of Absorption Promoter in Pressure-Sensitive Adhesive Base - A pressure-sensitive adhesive composition for transdermal absorption which contains a drug and a transdermal absorption promoter for the drug, characterized by further containing polyvinylpyrrolidone so as to stabilize the transdermal absorption promoter contained in the adhesive composition. Thus, the transdermal absorption promoter can be prevented from vaporization or degradation and a patch for external use containing the transdermal absorption promoter at a high concentration in using can be provided. | 09-18-2008 |
20080226698 | Amorphous drug transdermal systems, manufacturing methods, and stabilization - The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing at least one supersaturated active agent substantially in amorphous form. Further, the present invention refers to a method to stabilize and a method to reestablish the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process. | 09-18-2008 |
20080233177 | Fibre-Free Transdermal Therapeutic System and Method For Its Production - A transdermal therapeutic system which is free of fibrous constituents, and a method for the production of such a transdermal therapeutic system A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system. | 09-25-2008 |
20080254106 | Use Of Pirlindole For The Treatment Of Diseases Which Are Characterized By Proliferation Of T-Lymphocytes And/Or Hyperproliferation Of Keratinocytes In Particular Atopic Dermatitis And Psoriasis - The present invention relates to the use of Pirlindole, if needed with suitable adjuvants and additives for the production of a medicament for the treatment of diseases characterized by hyperproliferation of keratinocytes and/or T cells, in particular psoriasis and neurodermatitis as well as compositions comprising Pirlindole and use thereof. | 10-16-2008 |
20080279914 | Transdermal composition comprising piroxicam-inorganic material complex and patch system comprising the same - There is disclosed a transdermal composition comprising from about 0.1 to 25% by weight of a piroxicam-inorganic material complex composed of a swellable clay and piroxicam intercalated between layers thereof, from about 50 to 80% by weight of an adhesive polymeric material, and from about 0.1 to 25% by weight of an absorption enhancer. There is further disclosed a transdermal patch system comprising the subject transdermal composition. In the transdermal composition, piroxicam is dispersed on a molecular level between layers of a clay material. As a result, the dispersability, stability and solubility of the piroxicam are improved, the recrystallization of the piroxicam is prevented, and excellent absorption properties and skin permeability of the piroxicam are achieved. Therefore, excellent anti-inflammatory and analgesic effects are exhibited, little or no skin irritation is caused, thereby preventing occurrence of side effects, and the active ingredient is continuously administered by a transdermal route. | 11-13-2008 |
20090004256 | Lowly irritative adhesive patch - An adhesive patch for external use which is significantly inhibited from causing a rash, is less irritative to the skin, and sufficiently retains adhesion to the skin. The adhesive patch is characterized by employing a pressure-sensitive adhesive base into which a sucrose fatty acid ester has been incorporated. It does not exert physical influences on the skin, such as stresses imposed on the skin during wear and upon peeling, while sufficiently retaining adhesion to the skin. It is significantly inhibited from causing a rash, and the skin irritation thereof has been minimized. This adhesive patch for external use has ideal, lowly irritative properties which have been impossible to any conventional adhesive patch for external use. | 01-01-2009 |
20090028929 | Transdermal Patch - A transdermal patch suitable for the administration of nitroglycerin. | 01-29-2009 |
20090028930 | BRUISE AMELIORATION COMPOSITION AND METHOD OF USE - A bruise amelioration composition that can be applied for one hour to an affected site, such as a bruise, contusion or blister, in the form of a gel, liquid or adhesive bandage. The composition includes at least 40% by weight of glycerin and at least 2% by weight of primrose oil. Preferably, the composition includes a fragrance, such as peach oil and marjoram and 1% to 10% by weight of vitamins A, C, D, E and K. | 01-29-2009 |
20090041831 | FENTANYL SUSPENSION-BASED SILICONE ADHESIVE FORMULATIONS AND DEVICES FOR TRANSDERMAL DELIVERY OF FENTANYL - Silicone adhesive formulations are provided, in which fentanyl particles are suspended one or more a solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl. | 02-12-2009 |
20090047333 | Pressure-sensitive adhesive composition applicable to nail and adhesive agent for nail - The present invention aims at providing a pressure-sensitive adhesive composition applicable to nail, which shows superior adhesive performance (adhesive force, cohesion etc.), and superior drug releasability and drug stability, and an adhesive agent for nail, which uses this composition. The composition of the present invention contains a condensation polymer of a silicone resin and a silicone rubber. The composition of the present invention preferably contains not less than two kinds of condensation polymers having different resin/rubber ratios. The adhesive agent of the present invention has a support and an adhesive layer formed on one surface of the support, which contains the above-mentioned composition. | 02-19-2009 |
20090060986 | Transdermal delivery systems - Disclosed are bupivacaine transdermal delivery systems, and related methods. | 03-05-2009 |
20090068252 | Transdermal Absorption Preparation - A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining layer containing a drug and an acrylic pressure-sensitive adhesive and a skin adhesion layer containing a styrene-isoprene-styrene block copolymer. This preparation can continuously release bisoprolol at a constant concentration. Moreover, it can be easily produced. | 03-12-2009 |
20090110717 | TRANSMUCOSAL COMPOSITION - The invention provides a composition for delivering active agents through transmucosal administration, more particularly through the buccal mucosa. The composition is a unique transmucosal disk ( | 04-30-2009 |
20090123526 | Transdermally Absorbable Preparation - A transdermally absorbable preparation that even when a drug with poor solubility in a base is added in high concentration, is stable over time and can suppress crystallization of the drug, excelling in transdermal absorbability. There is provided a transdermally absorbable preparation, comprising a base and, added thereto, at least composite particles which are composed of a silicate compound and an organic acid and a drug. | 05-14-2009 |
20090130188 | Acrylic pressure sensitive adhesives - Solution acrylic polymers suitable for dispersing drugs are particularly useful in transdermal drug delivery applications. | 05-21-2009 |
20090148504 | TRANSDERMAL PHARMACEUTICAL PREPARATION - A percutaneous administration type pharmaceutical preparation in tape form comprising a flexible backing, which is not permeable by the active ingredient, and an adhesive base layer formed on said flexible backing; said adhesive base layer consisting essentially of an adhesive base material, ingredients, and an active ingredient, wherein said adhesive base is a copolymer containing one or more (meth) alkyl acrylate monomers and one or more monomers copolymerizable with the (a) monomer selected from the group of unsaturated ethylenically unsaturated monomers, and said ingredients are diethylene glycol monocetyl ether, octanoic acid and/or oleic acid, lauric acid diethanolamide, polyvinylpyrollidone; and said active ingredient is fentanyl. | 06-11-2009 |
20090169601 | Transdermal Therapeutic System for Administering Lipophilic and/or Sparingly Skin- Permeable Active Substances - A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups:
| 07-02-2009 |
20090169602 | Allergy Treatment by Epicutaneous Allergen Administration - The invention provides pharmaceutical compositions, kits, and methods for the treatment of allergy. The compositions are adapted for epicutaneous administration and comprise an allergen and at least one pharmaceutically acceptable excipient. They may be designed as adhesive patches, intradermal delivery devices, ointments, gels, sprays, or similar types of formulation suitable for administration to the skin. Furthermore, the invention provides the use of such compositions in the treatment of allergy. In particular, the compositions are administered to pre-treated skin, wherein the pre-treatment comprises partial or complete dekeratinisation of the epidermis at the selected site of administration. | 07-02-2009 |
20090169603 | Adhesive Pharmaceutical Preparation - In the adhesive pharmaceutical preparation of the invention, a pressure-sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a drug which is liquid at room temperature or around room temperature (in which, free base of bisoprolol is excluded) and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the drug can be specifically increased. As a result, not only it becomes possible to increase blending amount of the drug but also bleed of the drug from the pressure-sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained. | 07-02-2009 |
20090169604 | Adhesive Pharmaceutical Preparation Containing Bisoprolol - In the adhesive pharmaceutical preparation of the invention containing bisoprolol, a pressure-sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a free base of bisoprolol and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the free base of bisoprolol can be specifically increased. As a result, not only it becomes possible to increase blending amount of the free base of bisoprolol but also bleed of the free base of bisoprolol from the pressure-sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained. | 07-02-2009 |
20090169605 | Novel Tape Preparation - It is intended to provide a preparation for percutaneous administration of 2-(4-ethyl-1-piperazinyl)-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine (Compound A), which inhibits the generation of a metabolite and is capable of continuously maintaining a blood drug level. Specifically, a tape preparation comprising an adhesive layer formed on one surface of a support, characterized in that the adhesive layer contains (1) Compound A or a physiologically acceptable acid addition salt thereof, and (2) an acrylic adhesive, or (1) Compound A or a physiologically acceptable acid addition salt thereof, (2) an acrylic adhesive, and (3) a permeation enhancer is provided. | 07-02-2009 |
20090196910 | Sustained-Release Preparation of Statin Drugs - A preparation of statins for prolonged release. The preparation is a transdermal therapeutic system or hypodermic implantation system. And they overcome the problem of low bioavailability and increase patient compliance. The statins in the invention contain all of statins and responding salts, hydroxyl ester derivatives at 4-position. The invention has many advantages: for example, reduce dosage frequency, remain stable and lasting blood concentration of medicine, further improve the curative effect, provide patients with a convenient and safety means of administration, and obtain an effective period of up to seven days to months by taking medicine once. | 08-06-2009 |
20090208559 | DEVICE FOR DELIVERING ACTIVE INGREDIENTS TO HUMANS, ANIMALS AND PLANTS - A device for controlled delivery of an active ingredient to a receiving site ( | 08-20-2009 |
20090208560 | Cover material and plaster with cover material - A cover material adapted to cover the entirety of a patch is provided. The cover material has a support layer and, superimposed on a surface thereof, a pressure sensitive adhesive layer. The patch has a support film with a thickness of 12- to 30 μm and, superimposed thereon, a drug containing layer. The cover material may be attached to the surface of the support film and to the skin around the patch so that the pressure sensitive adhesive layer is brought into contact with edges of the drug containing layer. Additionally, the pressure sensitive adhesive layer contains an adhesive resulting from the polymerization of vinyl acetate or N-vinyl-2-pyrrolidone and a C | 08-20-2009 |
20090238860 | Adhesive Patch Less Irritative to Skin - Disclosed is an adhesive patch composed of an adhesive base agent and a supporting body wherein the adhesive base agent contains 3-30% by mass of a low-molecular-weight polyisobutylene and aluminum hydroxide and/or titanium oxide but not substantially containing water. Also disclosed is a skin irritation reducing agent used therefore. Further disclosed is an adhesive patch composed of a supporting body and an adhesive base agent which contains a thermoplastic rubber and a low-molecule-weight polyisobutylene but not substantially containing water. This adhesive patch is characterized in that the adhesive base agent further contains aluminum hydroxide and/or titanium oxide. Also disclosed is a skin irritation reducing agent used for such an adhesive patch. | 09-24-2009 |
20090246263 | Adhesive preparation - A patch preparation having a backing layer and a drug layer laminated on the backing layer; wherein the drug layer contains an adhesive containing at least one compound selected from the group consisting of fentanyl and pharmaceutically acceptable salts thereof, polyisobutylene, and a silicon-containing polymer; and a mass ratio of the polyisobutylene and the silicon-containing polymer in the adhesive is 20:1 to 7:3. | 10-01-2009 |
20090252782 | Transdermal Preparations Containing Hydrophoic Non-Steroidal Anti-Inflammatory Drugs - Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch. | 10-08-2009 |
20090258060 | Hydrogel Compositions - Hydrogel compositions are provided (a) that have a continuous hydrophobic phase and a discontinuous hydrophilic phase, (b) that have a discontinuous hydrophilic phase and a continuous hydrophilic phase, or (c) that are entirely composed of a continuous hydrophilic phase. The hydrophobic phase, if present, is composed of a hydrophobic polymer, particularly a hydrophobic pressure-sensitive adhesive (PSA), a plasticizing elastomer, a tackifying resin, and an optional antioxidant. The discontinuous hydrophilic phase, if present, is composed of a crosslinked hydrophilic polymer, particularly a crosslinked cellulosic polymer such as crosslinked sodium carboxymethylcellulose. For those hydrogel compositions containing a continuous hydrophilic phase, the components of the phase include a cellulose ester composition or an acrylate polymer or copolymer, and a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding thereto. Films prepared from hydrogel compositions containing or entirely composed of the aforementioned continuous hydrophilic phase can be made translucent, and may be prepared using either melt extrusion or solution casting. A preferred use of the hydrogel compositions is in wound dressings, although numerous other uses are possible as well. | 10-15-2009 |
20090274747 | Pressure-Sensitive Adhesive Base and Medical Adhesive Patch Including the Pressure-Sensitive Adhesive Base - A pressure-sensitive adhesive base which contains the liquid organic ingredient and which, despite this, has moderate pressure-sensitive adhesion properties (tackiness and cohesive force) and causes no bleeding. It hardly injures the keratin of the skin and is inhibited from irritating the skin. The pressure-sensitive adhesive base comprises the following ingredients (A) to (C): (A) a copolymer comprising units of a monomer containing a carboxy group and units of a (meth) acrylic ester; (B) one or more, liquid or semisolid organic compounds which are compatible with the copolymer of the ingredient (A); and (C) at least one member selected among polyvalent-metal oxides and polyvalent-metal hydroxides, the total content of the ingredient (C) being 0.001-5 mass % based on the whole pressure-sensitive adhesive base. The adhesive base contains substantially no water. | 11-05-2009 |
20090274748 | Nonaqueous pressure-sensitive adhesive for medicinal tape preparation for percutaneous absorption, medicinal tape preparation for percutaneous absorption, and process for producing the same - A nonaqueous pressure-sensitive adhesive for a medicinal tape preparation for percutaneous absorption comprising (a) a support, (b) a pressure-sensitive adhesive layer containing a drug and a nonaqueous pressure-sensitive adhesive and (c) a release film laminated in that order, and a medicinal tape preparation for percutaneous absorption comprising the adhesive. The nonaqueous pressure-sensitive adhesive may comprise a copolymer obtained by copolymerization of a (meth)acrylic monomer having an acetoacetyl group in the molecule and one or more monomers from among other (meth)acrylic monomers without acetoacetyl groups and copolymerizable vinyl monomers, in a nonaqueous solvent. Suitable (meth)acrylic monomers having an acetoacetyl group in the molecule are acetoacetoxyalkyl methacrylates, and especially 2-acetoacetoxyethyl methacrylate. The copolymer nonaqueous pressure-sensitive adhesive of the invention, comprising a (meth)acrylic monomer having an acetoacetyl group as a constituent monomer, is capable of containing large amounts of lipophilic oily substances in the pressure-sensitive adhesive layer, and during heat drying, the acetoacetyl groups undergo self-crosslinking to form a network structure as the solvent evaporates off, so that large amounts of oily substances such as the plasticizer can be included in the network structure. The pressure-sensitive adhesive of the invention uses no polyamine derivatives, isocyanate compounds, polyvalent metal chelate compounds, etc., as crosslinking agents, and therefore toxicity is not a concern and skin is not irritated. A medicinal tape preparation for percutaneous absorption of the invention has superior adhesive strength and cohesive strength, and is highly safe with low skin irritation. It also has excellent drug release and percutaneous absorption properties. | 11-05-2009 |
20090285877 | Percutaneous absorption preparation containing palonosetron - There is provided a percutaneous absorption preparation that has a simple laminated structure and a long shelf life, while maintaining excellent percutaneous absorption for palonosetron. The percutaneous absorption preparation comprises a support and a drug-containing pressure-sensitive adhesive layer formed on at least one side of the support, wherein the drug-containing pressure-sensitive adhesive layer comprises, as essential constituent components, an adhesive base, palonosetron or a pharmaceutically acceptable acid addition salt thereof, and at least one type of fatty alcohol selected from the group consisting of C6-12 straight-chain saturated alcohols, C10-22 straight-chain unsaturated alcohols, C10-22 branched alcohols and C10-15 cyclic alcohols, and the constituent components other than palonosetron or its pharmaceutically acceptable acid addition salt are carboxyl group-free components. | 11-19-2009 |
20090297590 | KETOTIFEN TRANSDERMAL DRUG DELIVERY SYSTEMS AND METHODS FOR TREATING OPHTHALMIC DISEASE - A ketotifen transdermal drug delivery system is provided. In certain embodiments, the system includes a support layer and a plaster layer provided on the support, wherein the plaster layer contains ketotifen freebase. Also provided are methods of using the delivery systems, e.g., for treatment of ophthalmic diseases, and kits containing the delivery systems. | 12-03-2009 |
20090317451 | PRESSURE-SENSITIVE ADHESIVE FOR SKIN SURFACE AND/OR TRANSDERMAL SUBSTANCE DELIVERY - A pressure-sensitive adhesive composition is described having a reservoir of medication or other substance and capable of intimate contact with a target area of skin, rapid conveyance of the medication onto and/or into the target area, and ready removal from the area of skin using water. Polyvinylpyrrolidone and glycerol mixtures have been found to dissolve a large number of medications while producing a self-tackifying, pressure-sensitive adhesive composition. | 12-24-2009 |
20090324696 | NAIL PATCH - The present subject matter provides a nail patch comprising a backing layer and a pressure-sensitive adhesive layer disposed on at least one side of the backing layer, wherein the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive base, terbinafine and/or a pharmacologically acceptable salt thereof, and sodium acetate and/or sorbitan monolaurate as a solubilizer. | 12-31-2009 |
20100034872 | ADHESIVE PATCH FOR PROTECTING AND TREATING VIRAL CUTANEOUS LESIONS - An adhesive patch for protecting and treating viral cutaneous lesions, in particular herpes and verrucas, the patch being permeable to gases and vapours and preventing passage of micro-organisms or bacteria therethrough. | 02-11-2010 |
20100047325 | ANALGESIC ANTI-INFLAMMATORY PATCHES FOR TOPICAL USE - The invention provides an analgesic anti-inflammatory patch of a hydrophobic type for topical application containing, in a Pressure Sensitive Adhesive(PSA), diclofenac sodium, pyrrolidone or a derivative thereof, a polyhydric alcohol fatty acid ester, and an organic acid. The patch exerts the following effects: | 02-25-2010 |
20100055160 | ANALGESIC ANTI-INFLAMMATORY PATCHES FOR TOPICAL USE - The invention provides an analgesic anti-inflammatory patch of a hydrophobic type for topical application containing, in a Pressure Sensitive Adhesive(PSA), diclofenac sodium, pyrrolidone or a derivative thereof, a polyhydric alcohol fatty acid ester, and an organic acid. The patch exerts the following effects: | 03-04-2010 |
20100062045 | METHOD FOR SUPPRESSING COLORING OF ADHESIVE PREPARTION CONTAINING DONEPEZIL AND METHOD FOR REDUCING AMOUNTS OF DONEPEZIL-RELATED SUBSTANCES FORMED - [Object] By suppressing coloring of an adhesive preparation containing donepezil, a naturally colored appearance is realized. | 03-11-2010 |
20100068248 | Patch and patch preparation - The present invention provides a patch containing a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer has a gel fraction of 50 wt %-75 wt %, and is comprised of a composition containing 33 wt %-65 wt % of a liquid rubber having a crosslinkable functional group in a molecule, which has an adhesive layer with a thickness sufficient for protection of a skin lesion and a wounded surface, which is flexible, adheres well to the skin, provides good feeling during adhesion, leaves less adhesive residue when removed from the skin, and shows good followability to skin deformation, as well as a patch preparation capable of sufficiently retaining a medicament and the like. | 03-18-2010 |
20100068249 | ABUSE-RESISTANT TRANSDERMAL DOSAGE FORM - The present invention comprises a transdermal dosage form comprising an active agent component having a skin contacting surface, an adverse agent component, and a barrier. The dosage form comprises at least one channel passing between proximal and distal surfaces of the active agent component. The barrier is interposed between the active agent component and the adverse agent component. In one aspect, the barrier is permeable to selected solvents and impermeable to diffusion of active and adverse agents in the absence of said solvent. In another aspect, the barrier is discontinuous, impermeable to diffusion of active and adverse agents, and the dosage form comprises at least one channel passing between the skin-contacting surface and the adverse agent component. | 03-18-2010 |
20100080842 | TRANSDERMAL EXTENDED-DELIVERY DONEPEZIL COMPOSITIONS AND METHODS FOR USING THE SAME - A transdermal extended-delivery donepezil active agent composition is provided. Aspects of the compositions of the invention include a donepezil active agent layer that is formulated to provide for multi-day delivery of a therapeutically effective amount of a donepezil active agent to a subject when the composition is topically applied to the subject. Also provided are methods of using the formulations, e.g., for administering a donepezil active agent to a subject, and kits containing the formulations. | 04-01-2010 |
20100150992 | Methods for Treatment of Ophthalmic Disease of an External Ophthalmic Tissue - A transdermal drug delivery system for treatment of ophthalmic diseases comprising a structure that a plaster layer containing a remedy for ophthalmic diseases is provided on a support, wherein the system is applied to a skin surface including a front surface of an eyelid to administer the remedy for ophthalmic diseases in the plaster layer to an ophthalmic topical tissue by percutaneous permeation substantially without being administered through a systemic blood flow. Use of the transdermal drug delivery system for treatment of ophthalmic diseases, comprising applying the transdermal drug delivery system to a skin surface including a front surface of an eyelid to transfer the remedy for ophthalmic diseases in the plaster layer to an ophthalmic topical tissue by percutaneous permeation substantially without being administered through a systemic blood flow, and a method for transferring the remedy for ophthalmic diseases to the ophthalmic topical tissue. | 06-17-2010 |
20100158990 | TRANSDERMAL METHOD AND PATCH FOR CORTICOSTEROID ADMINISTRATION - A method of treating an individual having a disease or for diagnostic purposes requiring administration of a corticosteroid, which involves applying to a portion of intact derma on the individual a transdermal patch having a backing layer and a matrix adhesive layer. The matrix adhesive layer includes a skin-compatible pressure-sensitive adhesive, a corticosteroid, and at least one permeation enhancer. The matrix adhesive layer, when applied to the skin of the individual, transdermally and continuously delivers the corticosteroid to the mammal for systemic treatment of the disease or for the diagnostic purpose. | 06-24-2010 |
20100158991 | PATCH PACKAGE STRUCTURE - A patch package structure which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, a peripheral area of the first sheet material having been sealed to a peripheral area of the second sheet material to constitute the package, and a patch disposed in the package; in which the patch includes a backing, a pressure-sensitive adhesive layer formed on at least one side of the backing, and a release liner which protects the pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having a weakening line for assisting a removal of the release liner; and in which the second sheet material has specific first protrudent part, second protrudent part, third protrudent part and elevated part in a central area thereof except the peripheral area thereof. | 06-24-2010 |
20100166836 | Transdermal Therapeutic System for Volatile and/or Thermo-Labile Substances - The present invention relates to a transdermal therapeutic system comprising at least one readily volatile and/or thermolabile active ingredient and/or auxiliary, which can be produced by laminating at least three components onto one another, namely a polymeric matrix layer, a likewise polymeric acceptor layer that absorbs the active ingredient and/or auxiliary at an increased rate, and a donor layer comprising, at the point of production, the volatile and/or thermolabile active ingredient and/or auxiliary. The system according to the invention is characterized in that, during or shortly after the lamination process, the donor layer combines with the acceptor layer as a result of migration of the readily volatile and/or thermolabile substances. | 07-01-2010 |
20100178323 | Dermal Delivery Device - A transdermal drug delivery device is disclosed. Over an extended wear period, the device causes cumulative moderate irritation plus significant irritation of less than 5% and/or achieves a meaningful degree of detachment over a seven day period of less than 20%. | 07-15-2010 |
20100209483 | TRANSDERMAL DELIVERY OF MEPTAZINOL - A delivery system for the delivery of a salt of meptazinol which increases the bioavailability of meptanizol by an effective amount to provide analgesic relief is disclosed. One embodiment of the delivery system is a transdermal device which increases the skin flux of meptazinol by an effective amount to provide analgesic relief. Also disclosed are methods of providing analgesic relief. | 08-19-2010 |
20100221313 | TRANSDERMAL RESERVOIR PATCH - A transdermal reservoir patch includes a first adhesive layer, a second adhesive layer and an occlusive backing layer configured to inhibit transport of a pharmaceutical agent from the first adhesive layer to the second adhesive layer. Methods of manufacturing the transdermal reservoir patch are disclosed. | 09-02-2010 |
20100226965 | COMPOSITIONS & METHODS FOR WOUND HEALING - The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osetoarthritic diseases, or diabetes). In particular, the present invention provides compositions and methods comprising molecules with linked α-gal epitopes for induction of an inflammatory response localized within or surrounding damaged tissue. In some embodiments, the present invention provides treatments for tissue repair in normal subjects and in subjects having impaired healing capabilities, such as diabetic and aged subjects. | 09-09-2010 |
20100247616 | PATCH AND PATCH PREPARATION - The present invention provides a patch and a patch preparation having an adhesive layer with a sufficient thickness, as well as appropriate skin adhesiveness and flexibility, which resist falling off from the skin even when a load is applied to the side opposite to the surface of the patch or patch preparation to be adhered to the skin, i.e., an exposed surface of a support of the patch or patch preparation, and show low irritation to the skin; an adhesive layer, which is obtained by crosslinking a liquid rubber having a crosslinkable functional group in a molecule in the presence of a crosslinking agent having a functional group number of 3 or below and a catalyst, on at least one surface of a support; and a patch preparation having an adhesive layer containing a pharmaceutical agent. | 09-30-2010 |
20100272784 | WATER-SOLUBLE PRESSURE SENSITIVE ADHESIVES - A water-soluble pressure sensitive adhesive comprises a homogeneous blend comprising (a) a polymer selected from the group consisting of N-vinyl caprolactam homopolymers, N-vinyl pyrrolidone copolymers, and mixtures thereof and (b) a non-volatile plasticizer comprising a monohydric or polyhydric alcohol having hydrophilic-lipophilic balance of about 2 to about 10. The N-vinyl pyrrolidone copolymers comprise about 60% or less by weight N-vinyl pyrrolidone. | 10-28-2010 |
20110002976 | MEDICATED PATCH - Provided is a medicated patch containing a medicinal agent, an adhesive base material and a tackifier, where the medicinal agent is varenicline or a pharmaceutically acceptable salt thereof, the adhesive base material is a rubbery adhesive base material and the tackifier is a rosin-based tackifier selected from the group consisting of rosin, rosin derivatives and hydrogenated products of the foregoing, or a non-rosin-based tackifier selected from the group consisting of aliphatic hydrocarbon resins and alicyclic hydrocarbon resins, and when a non-rosin-based tackifier is added as the tackifier, a solubilizer for the medicinal agent is further added, the solubilizer containing an alcohol-based solubilizer having at least a solubility parameter of 20-35. | 01-06-2011 |
20110008413 | Compositions and Methods of Topical Drug Delivery for the Treatment of Carpal Tunnel Syndrome - The present invention generally relates to transdermal drug delivery systems. More particularly, the present invention provides compositions and transdermal drug delivery systems for the treatment and/or relief of symptoms associated with carpal tunnel syndrome or tendonitis. | 01-13-2011 |
20110027345 | COMPOSITION CONTAINING ROTIGOTINE AND USE THEREOF AND TRANSDERMAL PATCH CONTAINING THE COMPOSITION - The present invention relates to a composition containing Rotigotine and the use thereof in the manufacture of a Rotigotine-containing transdermal patch, wherein said composition is based on a matrix mixture system formed from a combination of an acrylic pressure-sensitive adhesive with a silicone pressure-sensitive adhesive, and polyvinylpyrrolidone which are present in a particular weight ratio, wherein (1) the acrylic pressure-sensitive adhesive is present in an amount of about 1-25% by weight in the matrix mixture system, (2) the silicone pressure-sensitive adhesive is present in an amount of about 65-98% by weight in the matrix mixture system, and (3) the polyvinylpyrrolidone is present in an amount of about 1-10% by weight in the matrix mixture system, and comprises 1-40% of Rotigotine on the basis of the total weight of the composition. The present invention further relates to an improved transdermal patch containing Rotigotine comprising said composition. Said patch has improved properties in the solubility, release and initial penetration level of Rotigotine. | 02-03-2011 |
20110097384 | TRANSDERMAL DRUG DELIVERY DEVICE INCLUDING AN OCCLUSIVE BACKING - A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer. | 04-28-2011 |
20110104244 | TRANSDERMAL THERAPEUTIC SYSTEM PROVIDED WITH IMPROVED LONG-TERM CARRYING COMFORT - The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterized in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time. | 05-05-2011 |
20110104245 | PRESSURE-SENSITIVE ADHESIVES BASED ON ETHYLENE-VINYL ACETATE COPOLYMERS AND ADHESIVE RESINS, FOR MEDICAL APPLICATION PURPOSES - A pressure sensitive adhesive for medicinal application purposes, based on ethylene-vinyl acetate copolymers is characterized in that it contains as polymer component (A) an ethylene-vinyl acetate copolymer or a combination of at least two ethylene-vinyl acetate copolymers, and as component (B) an adhesive resin or a combination of adhesive resins at a portion of up to 55%-wt, relative to the sum of components (A) and (B) without active substances or other auxiliary substances. | 05-05-2011 |
20110123598 | PATCH AND PATCH PREPARATION - The patch according to an embodiment of the present invention includes: a support; and a pressure-sensitive adhesive layer on at least one surface of the support, wherein: the pressure-sensitive adhesive layer contains an acrylic copolymer obtained by copolymerizing monomer components containing (a) at least one kind of a monomer of a (meth)acrylic acid alkyl ester and (b) at least one kind of a monomer of an N-hydroxyalkyl(meth)acrylamide; a content of the (meth)acrylic acid alkyl ester monomer (a) with respect to a total amount of the monomer components is 50 wt % to 90 wt % and a content of the N-hydroxyalkyl(meth)acrylamide monomer (b) with respect to the total amount is 1 wt % to 20 wt %; and the monomer components are substantially free of a monomer having a carboxyl group. | 05-26-2011 |
20110123599 | AROMA THERAPY PATCH - The present invention relates to an aroma therapy patch including a herbal layer containing herbal extract which is formed on one surface of a substrate having a specific shape, and an adhesive layer formed on the other surface of the substrate, wherein at least one surface of the substrate is colored. The aroma therapy patch of the present invention exerts aromatic effects by the actions of herbal extracts as well as chromatherapeutic effects induced by a specific color used therein, which can be used easily and cost-effectively by an ordinary person. | 05-26-2011 |
20110150974 | Agent For Oral Mucosal Administration - A medicament used for prophylactic and/or therapeutic treatment of xerostomia, which is in the form for oral mucosal administration comprising a spirooxathiolane quinuclidine derivative represented by the following general formula (I) or an acid addition salt thereof: | 06-23-2011 |
20110165222 | TRANSDERMAL COMPOSITIONS CONTAINING LOW MOLECULAR WEIGHT DRUGS WHICH ARE LIQUID AT ROOM TEMPERATURES - A transdermal composition is disclosed which contains a blend of one or more polymers, one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures. The composition is substantially free of water and liquids which have a normal boiling point (a) optionally below processing temperatures and (b) greater than or equal to the temperature of the low molecular weight drugs. The composition does not suffer from the substantial loss of the lower molecular weight drug during production of the transdermal system. A transdermal composition is also disclosed which has one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures, and a polymer matrix including one or more high shear resistant polymers. The high shear resistant polymer(s) reduce the plasticizing effect of the low molecular weight drug, and has sufficient tack and shear for application to a human being. | 07-07-2011 |
20110182971 | TRANSEPIDERMAL DRUG DELIVERY SYSTEM CONTAINING TULOBUTEROL - Disclosed is a pharmaceutical composition containing tulobuterol. More specifically, disclosed is a transepidermal drug delivery system including a drug layer containing tulobuterol and a natural rubber-based adhesive material, and a supporter adhered to one surface of the drug layer to support the drug layer, wherein the natural rubber-based adhesive material comprises 10 to 40 parts by weight of a natural rubber, 54.5 to 85 parts by weight of a rosin ester resin and an acid value controller, and the drug layer has a thickness of 25 μm to 75 μm. | 07-28-2011 |
20110189261 | TRANSDERMALLY ABSORBABLE PREPARATION - Disclosed is a transdermally absorbable preparation in which the crystallization of a medicinal agent can be prevented even when the medicinal agent has poor solubility in a base material and is contained in the base material at a high concentration, and which exhibits excellent long-term stability and transdermal absorbability of the medicinal agent. By adding a complex of an organic acid and an organic acid salt and a medicinal agent to a base material, it becomes possible to produce a transdermally absorbable preparation in which the crystallization of the medicinal agent can be prevented and which has excellent preparation properties and transdermal absorbability. Also disclosed is use of a complex of an organic and an organic acid salt for preventing the crystallization of a medicinal agent in a transdermally absorbable preparation. | 08-04-2011 |
20110195109 | ADHESIVE SKIN PATCH AND PACKAGED PRODUCT - Provided is a patch | 08-11-2011 |
20110223235 | SELEGILINE-CONTAINING ADHESIVE PREPARATION - The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (−)-(R)—N,α-dimethyl-N-2-propynylphenethylamine and/or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive and one or two or more stabilizers selected from the group consisting of 2-mercaptobenzimidazole, sodium sulfite, butylhydroxyanisole and butylhydroxytoluene. | 09-15-2011 |
20110223236 | SELEGILINE-CONTAINING ADHESIVE PREPARATION - The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (−)-(R)—N,α-dimethyl-N-2-propynylphenethylamine and/or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive and a component which is liquid at 25° C. and has two or more ester bonds in one molecule thereof. | 09-15-2011 |
20110256210 | Transdermal Delivery - Dosing regimen for transdermal delivery of hormones comprising a monthly treatment cycle with a fixed treatment interval and a variable rest interval. | 10-20-2011 |
20110262523 | MEDICAL ADHESIVE TAPE AND MEDICAL ARTICLES MADE OF THE SAME - The present invention provides a medical adhesive tape comprising a non-woven fabric substrate of a metallocene polypropylene copolymer; and a medical pressure-sensitive adhesive coated on at least one side of said substrate. A medical article comprising a medicament and the medical adhesive tape of the invention is also provided. | 10-27-2011 |
20110268785 | Propynylaminoindan Transdermal Compositions - Propynylaminoindan (e.g., Rasagiline) transdermal compositions are provided. Aspects of the transdermal compositions include a matrix of the propynylaminoindan in a pressure sensitive adhesive comprising a carboxylated polymer. In some instances, the matrix further includes a cationic acrylic copolymer. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions. | 11-03-2011 |
20110311611 | WATER DISSOLVABLE ADHERENT ARTICLE FOR TOPICAL APPLICATION - An adherent article with a first substrate, soluble or dispersible in aqueous solutions, with a first and second side, and an aqueous-insoluble second substrate disposed on at least a portion of the second side of the first substrate, optionally, with an adhesive applied to at least a portion of the first side of the first substrate, and a release liner positioned over a portion of the first substrate or adhesive to cover and protect at least a portion of the adhesive. | 12-22-2011 |
20110318405 | Chemical Combination and Method for Increasing Delivery of Coenzyme Q10 - The present invention relates to a chemical combination and method for increasing delivery of Coenzyme Q10. The chemical combination comprises Coenzyme Q10 mixed with at least one chemical. The at least one chemical includes cyclic terpene containing essential oil(s) that permit unprecedented levels of Coenzyme Q10 to be made available for delivery and absorption, increasing bioavailability, as well as overcoming the previous limits. A transdermal patch including a layer containing Coenzyme Q10 is also provided. | 12-29-2011 |
20120027840 | ADHESIVE PATCH AND PATCH PREPARATION - The present invention provides an adhesive patch including a backing and a pressure-sensitive adhesive layer formed on at least one surface of the backing, in which (a) a surface of the pressure-sensitive adhesive layer has a logarithmic decrement, as determined by the rigid-pendulum free-damped oscillation method, in the range of 0.03 to 0.35, and (b) the pressure-sensitive adhesive layer has a maximum shear displacement in the range of 18 μm to 1,000 μm. The present invention further provides a patch preparation containing a drug. The adhesive patch and the patch preparation according to the present invention are reduced in skin irritation during wear. | 02-02-2012 |
20120114738 | TRANSDERMAL PATCH - The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAE or its pharmacologically acceptable salt. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: 2-amino-1-(2′,5′-dimethoxyphenyl)ethanol or its pharmacologically acceptable salt; 40 to 98% by weight of acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and 1 to 30% by weight of saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 10 to 30. | 05-10-2012 |
20120189686 | TRANSDERMAL LEVONORGESTREL DEVICE AND DELIVERY - Described are transdermal drug delivery systems for the transdermal administration of levonorgestrel, comprising a polymer matrix and levonorgestrel acetate. Methods of making and using such systems also are described. | 07-26-2012 |
20120195956 | ADHESIVE SKIN PATCH - The present invention provides an adhesive skin patch that permits excellent and prolonged percutaneous absorption of tulobuterol and that can be stably applied to the skin for a long period of time with less skin irritation. The adhesive skin patch comprises a base material and a medicated layer provided on one surface of the base material. The medicated layer contains 1 to 30% by weight of a resolvent, 40 to 98% by weight of a pressure-sensitive adhesive, and tulobuterol. The resolvent contains an aliphatic alcohol having a branched-chain structure or a double bond in its C8 to C30 carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing 70% by weight or more of an alkyl(meth)acrylate whose alkyl group has 6 to 20 carbon atoms. | 08-02-2012 |
20120231064 | PHARMACEUTICAL CARRIER DEVICE SUITABLE FOR DELIVERY OF PHARMACEUTICAL COMPOUNDS TO MUCOSAL SURFACES - The present invention relates to a pharmaceutical delivery device for application of a pharmaceutical to mucosal surfaces. The device comprises an adhesive layer and a non-adhesive backing layer, and the pharmaceutical may be provided in either or both layers. Upon application, the device adheres to the mucosal surface, providing localized drug delivery and protection to the treatment site. The kinetics of erodability are easily adjusted by varying the number of layers and/or the components. | 09-13-2012 |
20120269881 | TRANSDERMAL DRUG DELIVERY DEVICE INCLUDING AN OCCLUSIVE BACKING - A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer. | 10-25-2012 |
20130095168 | TRANSDERMAL DRUG DELIVERY SYSTEM CONTAINING DONEPEZIL - The present invention provides a transdermal drug delivery system comprising a drug-containing matrix layer comprising: (a) donepezil or a pharmaceutically acceptable salt thereof as an active ingredient; and (b) an acrylate-rubber hybrid as an adhesive. | 04-18-2013 |
20140072615 | TRANSDERMAL HORMONE DELIVERY SYSTEM: COMPOSITIONS AND METHODS - A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed. | 03-13-2014 |
20140086978 | Transdermal Therapeutic System Provided With Improved Long-Term Carrying Comfort - The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time. | 03-27-2014 |
20140141059 | PATCH - Provided is a patch that ensures high storage stability of donepezil or a salt thereof and allows stable transdermal administration of the donepezil or salt thereof in an amount that provides a pharmaceutical effect. The patch includes a substrate | 05-22-2014 |
20140186428 | PATCH AND METHOD FOR PRODUCING THE SAME - A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising:
| 07-03-2014 |
20140234395 | PLASTER HAVING ADJUSTABLE OCCLUSION - Transdermal or topical plasters containing active ingredient are provided that include a non-occlusive back layer, a matrix formed from of one or more polymer layers having at least one pharmaceutical active ingredient in one or more of the layers, in which the structure-forming base polymers of the layer(s) are non-occlusive or only slightly occlusive and a second polymer that has a low water-vapor permeability and that is immiscible or only very slightly miscible with the base polymer is dispersed in at least one of the polymer layers. | 08-21-2014 |
20140242150 | THERAPEUTIC COMPOSITIONS AND METHODS OF TREATMENT WITH CAPSIANOSIDE-TYPE COMPOUNDS - The present invention discloses the use of certain compounds as therapeutic agents, and in particular as analgesics and anti-inflammatory agents. Such compounds include, for example, certain diterpene monoglycosides and diterpene diglycosides. The compounds of the present invention may be synthesized or isolated from the fruit of the genus | 08-28-2014 |
20140242151 | ADHESIVE SKIN PATCH - The present invention provides an adhesive skin patch that permits excellent and prolonged percutaneous absorption of tulobuterol and that can be stably applied to the skin for a long period of time with less skin irritation. The adhesive skin patch comprises a base material and a medicated layer provided on one surface of the base material. The medicated layer contains 1 to 30% by weight of a resolvent, 40 to 98% by weight of a pressure-sensitive adhesive, and tulobuterol. The resolvent contains an aliphatic alcohol having a branched-chain structure or a double bond in its C8 to C30 carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing 70% by weight or more of an alkyl(meth)acrylate whose alkyl group has 6 to 20 carbon atoms. | 08-28-2014 |
20140271798 | Topical Copper Ion Treatments and Methods of Making Topical Copper Ion Treatments for Use in Various Anatomical Areas of the Body - A topical copper ion treatment in basic form comprises a copper ion-containing solution composed of a biocompatible solution containing copper ions obtained by leaching of the copper ions from copper metal into the solution. The copper ion-containing solution can be combined with various carriers to form various forms of the copper ion treatment including creams, gels, lotions, foams, pastes, tampons, solutions, suppositories, body wipes, wound dressings, skin patches, and suture material. A method of making the copper ion-containing solution involves placing solid copper metal in a quantity of a biocompatible solution and maintaining the solution at a specified temperature for a predetermined period of time during which copper ions leach from the copper metal into the solution, and thereafter separating the solution from the solid copper metal. | 09-18-2014 |
20140308338 | DRESSINGS THAT CONTAIN ACTIVE SUBSTANCE - A dressing for applying to the skin is characterized in that the adhesive mass is applied discontinuously in a strip or wave and contains an active substance. | 10-16-2014 |
20140356412 | Non-Aqueous Patch | 12-04-2014 |
20140363487 | TRANSDERMAL DELIVERY SYSTEM COMPRISING BUPRENORPHINE - The invention relates to transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing self-adhesive layer structure comprising A) a buprenoφhine-impermeable backing layer, and B) a buprenorphine-containing pressure-sensitive adhesive layer on said buprenorphine-impermeable backing layer, the adhesive layer comprising a) at least one polymer-based pressure-sensitive adhesive, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, and c) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid and linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture, and the carboxylic acid buprenorphine mixture forms dispersed deposits in the said pressure-sensitive adhesive, wherein said buprenorphine-containing pressure-sensitive adhesive layer is the skin contact layer. | 12-11-2014 |
20140363488 | Adhesive patch - A method of treating Herpes Labialis includes assembling a patch having hydrocolloid particles added to a layer of adhesive to so configure the patch to have a limited absorption of moisture into the patch combined with a permeability of moisture through and out of the patch. The method additionally includes providing the patch to the user and having the user apply the patch to the user's face in treating the Herpes Labialis, and configuring the patch to be less visible when applied to the user's face than a cream is visible when applied to the user's face. | 12-11-2014 |
20140370076 | TRANSDERMAL DRUG DELIVERY SYSTEM CONTAINING DONEPEZIL - The present invention provides a transdermal drug delivery system comprising donepezil or its pharmaceutically acceptable salt and method of making the same. | 12-18-2014 |
20140370077 | TRANSDERMAL DRUG DELIVERY SYSTEM CONTAINING FENTANYL - The present invention provides a transdermal drug delivery system comprising fentanyl or its pharmaceutically acceptable salt and method of making the same. | 12-18-2014 |
20150037393 | ADHESIVE PATCHES FOR USE IN SUNLESS TANNING - Adhesive patches for protecting skin imperfections such as age spots, from discoloring and/or darkening during sunless tanning are provided herein. The adhesive patches are sized and shaped to fully or partially cover the skin imperfections during application of a sunless tanning product such to provide a user with uniform color development over the entire skin, and, in some embodiments, to allow for the skin imperfection to appear less visible. | 02-05-2015 |
20160030362 | SILICONE-CONTAINING ACRYLIC POLYMERS FOR TRANSDERMAL DRUG DELIVERY COMPOSITIONS - Described herein are silicone-containing acrylic polymers useful, for example, in transdermal drug delivery compositions, to methods of making and using them, to transdermal drug delivery compositions comprising them, and to methods of making and using such transdermal drug delivery compositions. The polymers are particular suitable for formulating amine drugs, such as amphetamine, methylphenidate, rivastigmine, paroxetine and clonidine. | 02-04-2016 |
20160081946 | 4:3 NALTREXONE: 5-METHYL-2-FURALDEHYDE COCRYSTAL - A 4:3 naltrexone: 5-methyl-2-furaldehyde cocrystal and its use as an opioid antagonist are disclosed. The invention also relates to a drug-in-adhesive transdermal patch containing the analgesic fentanyl, a mu opioid agonist, or an analog thereof and a 4:3 naltrexone: 5-methyl-2-furaldehyde cocrystal, as an opioid antagonist. A transdermal patch of the invention is tamper-resistant and an abuse deterrent which protects against drug misuse or abuse. The invention also provides a method of treating pain, such as acute, chronic, or intermittent pain, by applying a drug-in-adhesive transdermal patch according to the invention to the skin of a patient in need thereof. Also disclosed is an improved transdermal patch for administering fentanyl or an analog thereof, or for administering a mu opioid agonist, the improvement wherein the transdermal patch contains a 4:3 naltrexone: 5-methyl-2-furaldehyde cocrystal in an abuse limiting amount. The improved transdermal patch may be a drug-in-adhesive transdermal patch or a reservoir transdermal patch. | 03-24-2016 |
20160101100 | TRANSDERMAL DELIVERY SYSTEM - The invention relates to transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing self-adhesive layer structure comprising
| 04-14-2016 |
20160120823 | TRANSDERMAL DELIVERY SYSTEM COMPRISING BUPRENORPHINE - The invention relates to transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing self-adhesive layer structure comprising
| 05-05-2016 |
20160175447 | TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTERING THE ACTIVE SUBSTANCE BUPRENORPHINE | 06-23-2016 |
20160199315 | ADHESIVE PATCH | 07-14-2016 |
20160374954 | PRESSURE-SENSITIVE ADHESIVES FOR TRANSDERMAL DRUG DELIVERY - Described are pressure-sensitive adhesive polymers (PSAs) useful, for example, for application to the skin, such as in the field of transdermal drug delivery. The PSAs include polar groups modeled on one or more polar portions of skin lipids, which contribute to good skin adhesion properties. Methods of making the PSAs, compositions comprising them, and methods of making and using them also are provided. | 12-29-2016 |
20160374955 | TRANSDERMAL NICOTINE SALT DELIVERY SYSTEM - A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties. | 12-29-2016 |
20170231959 | Ropinirole-Containing Adhesive Patch | 08-17-2017 |