Class / Patent application number | Description | Number of patent applications / Date published |
424900323 | Metal is paramagnetic | 44 |
20090208420 | IRON OXIDE-BINDING PEPTIDES - The invention relates to diagnostic compositions comprising metal oxide particles, especially iron oxide particles, which are coated with binding peptides. The binding peptides bind with high affinity to the metal oxide particles so that the peptide-coated metal oxide particles are suitable for medical applications, for example as contrast media for magnetic resonance imaging. | 08-20-2009 |
20090220434 | NANOPARTICLES THAT FACILITATE IMAGING OF BIOLOGICAL TISSUE AND METHODS OF FORMING THE SAME - Nanoparticles that facilitate imaging of biological tissue and methods for formulating the nanoparticles are provided. In order to form suitable nanoparticles for imaging, an anionic surfactant may be applied to superparamagnetic nanoparticles to form modified nanoparticles. The modified nanoparticles may be mixed with a polymer in a solvent to form a first mixture, and a non-solvent may be mixed with the first mixture to form a second mixture. An emulsion may be formed from the second mixture and the polymeric nanoparticles may be isolated from the emulsion. In certain embodiments of the invention, an antibody may be attached to the polymeric nanoparticles to facilitate attachment of the nanoparticles to biological tissue. | 09-03-2009 |
20090263331 | MULTIFUNCTION NANOCONJUGATES FOR IMAGING APPLICATIONS AND TARGETED TREATMENT - The present invention relates to nanoconjugates. In particular, the present invention provides nanoconjugates for diagnostic (e.g., imaging), research, and clinical (e.g., targeted treatment) applications. | 10-22-2009 |
20090317335 | Hybrid Nanomaterials as Multimodal Imaging Contrast Agents - The presently disclosed subject matter provides hybrid nanomaterials for use as magnetic resonance imaging (MRI), optical and/or multimodal contrast imaging agents. The hybrid nanomaterials comprise a polymeric matrix material and a plurality of coordination complexes, each coordination complex comprising a functionalized chelating group and a paramagnetic metal ion. The nanoparticle can further comprise a luminophore. Methods of synthesizing and using the nanoparticles are provided. The nanoparticles can be used to diagnose diseases, including cancer, cardiovascular disease, and diseases related to inflammation. | 12-24-2009 |
20100003197 | Ultrasmall superparamagnetic iron oxide nanoparticles and uses thereof - The present invention provides biomimetic contrast agents, dual functional contrast agents effective for therapeutic gene delivery and magnetic nanoparticles which comprise functionalized iron oxide nanoparticle cores, one of an inert gold layer, a layer of inert metal seeds or a silica layer and, optionally, one or both of an outer gold-silver nanoshell or a targeting ligand attached to the inert gold layer or the gold-silver nanoshell. Also provided are methods of in vivo magnetic resonance imaging, of treating primary or metastatic cancers or of ablating atherosclerotic plaque using the contrast agents and magnetic particles. In addition, kits comprising the biomimetic contrast agents, dual contrast agents and magnetic nanoparticles. | 01-07-2010 |
20100297026 | Imaging of Activated Vascular Endothelium Using Immunomagnetic MRI Contrast Agents - Immunomagnetic nanoparticles are used as a contrast agent for enhancing medical diagnostic imaging such as magnetic resonance imaging (MRI). The present invention is directed to methods of making targeted MRI contrast agents from immunomagnetic particles, and to methods of using such MRI contrast agents. Typically, such targeted MRI contrast agents provide enhanced relaxivity, improved signal-to-noise, targeting ability, and resistance to agglomeration. Methods of making such MRI contrast agents typically afford better control over particle size, and methods of using such MRI contrast agents typically can afford enhanced blood clearance rates and distribution. The ability to use the contrast agents im MRI provides a tool in the diagnosis and treatment of several disease states. | 11-25-2010 |
20100310473 | Targeting Brain Cells Via Ophthalmic Delivery - It is disclosed here that nucleic acid-based agents can be delivered to the brain of a human or non-human animal having a leakage in the blood brain barrier by administering the agents through the eye. Brain tissues and cells can be imaged in vivo (e.g., by magnetic resonance imaging) by linking a contrast agent to a targeting nucleic acid that can hybridize to a target nucleic acid located at the brain site to be imaged and administering the contrast agentltargeting nucleic acid conjugate through the eye. Similarly, a nucleic acid based drug (e.g., as an antisense nucleic acid or a therapeutic agent linked to a targeting nucleic acid that can hybridize to a target nucleic located at a disease site in the brain) can be administered through the eye to treat a brain disease. | 12-09-2010 |
20100310474 | PROTEIN CAGES FOR THE DELIVERY OF MEDICAL IMAGING AND THERAPEUTIC AGENTS - The present invention is directed to novel compositions and methods utilizing delivery agents comprising protein cages, medical imaging agents and therapeutic agents. | 12-09-2010 |
20110104077 | Magnetic nanocomposite with multi-biofunctional groups and method for fabricating the same - The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached. | 05-05-2011 |
20110123458 | POLYMER-METAL COMPLEX COMPOSITE HAVING MRI CONTRAST ABILITY AND MRI CONTRASTING AND/OR ANTITUMOR COMPOSITION USING THE SAME - The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood. | 05-26-2011 |
20110206619 | GOLD COATED SUPER PARAMAGNETIC IRON OXIDE NANO-PARTICLES (SPIONS) AND A METHOD OF SYNTHESIZING THE SAME - The various embodiments herein provide a gold coated SPIONs with jagged surface. The gold coated SPIONs have a core and a shell. The core is a SPION molecule and the shell is a jagged gold layer. A non-uniform polymeric gap exists between the core and the shell. The embodiments also provide a method of producing the jagged gold coated SPIONs by mixing a colloidal dispersion of SPIONs with pH sensitive polymers. Adding a gold salt to the above mixture and reducing the gold salt to form jagged gold coated SPIONs. | 08-25-2011 |
20110223112 | UNSATURATED POLYESTER COATED MAGNETIC ULTRA-FINE PARTICLES FOR BIOLOGICAL APPLICATIONS - Unsaturated polyesters e.g. poly (ethylene glycol fumarate) (PEGF) were developed as new coating materials for iron oxide nanoparticles. Different strategies were adopted in their synthesis to provide different characteristics including solubility, molecular weight and structure also degrees of unsaturation. After synthesis of the nanoparticles; the material was applied as a coating on them. These materials were applicable without further processing, however, coatings were cured via thermal, redox or photo initiated crosslinking on the nanoparticles to provide rigid shells on the surface of nanoparticles. | 09-15-2011 |
20110286938 | NON-INVASIVE DETECTION OF COMPLEMENT-MEDIATED INFLAMMATION USING CR2-TARGETED NANOPARTICLES - Methods of non-invasive imaging of complement-mediated inflammation are provided. Compositions including CR-targeted ultrasmall superparamagnetic nanoparticles or aggregates thereof for use with those methods are also provided. | 11-24-2011 |
20110318275 | MULTIFUNCTIONAL CONTRAST AGENT USING BIOCOMPATIBLE POLYMER AND PREPARATION METHOD - The present invention relates to a biocompatible contrast agent and a method of its preparation. More particularly, the present invention relates to a multifunctional contrast agent manufactured by prepairing a novel polysuccinimide-based polymer by introducing an alkanolamine group to the main group of the polysuccinimide in addition to a biocompatible hydrophilic group, which improves bioavailability, and a hydrophobic group, which enables to maintain the form of stable nanoparticles during the formation of nano particles for a long period of time and to encapsulate a hydrophobic anticancer agent. | 12-29-2011 |
20120045399 | POSITIVELY-CHARGED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE, CONTRAST AGENT USING THE SAME AND METHOD OF PREPARING THE SAME - Provided are a positively-charged superparamagnetic iron oxide nanoparticle (SPION), a contrast agent using the same, and a method of preparing the same. The positively-charged SPION includes a SPION, a polymer layer including a polymer containing many carboxyl groups coated on a surface of the SPION, and a cationic material coupled via an amide bond to a surface of the polymer layer. Therefore, the SPION may be prepared in a simple and reproducible process to have hydrophilicity and a strong positive charge. The prepared positively-charged SPION may have high uptake into a cell and stability, and be used in various applications as an effective contrast agent through non-invasive in vivo imaging. | 02-23-2012 |
20120121518 | Multifunctional imaging and therapeutic nanoparticles - Multifunctional nanoparticles for imaging and therapeutic drug delivery made from amphiphilic block copolymers having a hydrophobic block and one or more hydrophilic blocks, and at least one internal and one terminal chelating agent units having a paramagnetic metal ion associated therewith. | 05-17-2012 |
20120141382 | APTAMER MODULATORS OF COMPLEMENT PROTEIN C3 AND BIOLOGICALLY ACTIVE PROTEOLYTIC PRODUCTS THEREOF - This invention relates to nucleic acid aptamers that recognize and bind the complement protein C3 or its biologically active proteolytic products and methods of their use. Particularly preferred are bi-functional aptamer construct that binding specifically with C3b or iC3b, and another target protein. Use of these molecular constructs for commandeering the opsonization process is also described herein. | 06-07-2012 |
20120164079 | IMAGING OF BIOLOGICAL TISSUE UTILIZING NANOPARTICLES - Methods for NMR microimaging of biological tissue are provided. Polymeric nanoparticles are provided as a contrast agent to subject tissue to be imaged. Each polymeric nanoparticle may include an iron oxide core that exhibits superparamagnetic properties that enhance tissue imaging when placed within a magnetic field, an anionic surfacant applied to the core, a polymeric layer that encapsulates the core and the anionic surfacant, and an antibody attached to the polymeric layer to facilitate attachment to the subject tissue. Following the provision of the polymeric nanoparticles as a contrast agent to the subject tissue, the subject tissue may be images utilizing a twenty-one Tesla microimaging technique. | 06-28-2012 |
20120230919 | MRI CONTRAST AGENT COATED WITH CARBOXYLATED MANNAN AND METHOD FOR PRODUCING THE SAME - The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI. | 09-13-2012 |
20130095043 | SYNTHESIS OF HIGH-PERFORMANCE IRON OXIDE PARTICLE TRACERS FOR MAGNETIC PARTICLE IMAGING (MPI) - The present invention relates to a method of forming iron oxide nanoparticles comprising the steps of (a) suspending iron oxide/hydroxide and oleic acid or a derivative thereof in a primary organic solvent; (b) increasing the temperature of the suspension by a defined rate up to a maximum of 340° C. to 500° C.; (c) aging the suspension at the maximum temperature of step (b) for about 0.5 to 6 h; (d) cooling the suspension; (e) adding a secondary organic solvent; (f) precipitating nanoparticles by adding a non-solvent and removing excess solvent; (g) dispersing said nanoparticles in said secondary organic solvent; (h) mixing the dispersion of step (g) with a solution of a polymer; and (i) optionally removing said secondary organic solvent. The present invention further relates to an iron oxide nanoparticle obtainable by the method, the additional modification, encapsulation and decoration of such nanoparticles, as well as the use of the nanoparticles as tracers for Magnetic Particle Imaging (MPI), Magnetic Particle Spectroscopy (MPS). | 04-18-2013 |
20130108554 | CONTRAST AGENTS | 05-02-2013 |
20130121928 | Method for Diagnostically Imaging Lesions in the Peripheral Nervous System - An improved method for diagnosing and characterizing peripheral nerve lesions to permit early identification and characterization of peripheral nerve injuries that will require surgical intervention. | 05-16-2013 |
20130121929 | Polyol and Polyether Iron Oxide Complexes as Pharmacological and/or MRI Contrast Agents - Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods. | 05-16-2013 |
20130195767 | Magnetic Nanoparticles - A magnetic nanoparticle includes a magnetic core and a superparamagnetic outer shell, in which the outer shell enhances magnetic properties of the nanoparticle. The enhanced magnetic properties of the magnetic nanoparticle allow for highly sensitive detection as well as diminished non-specific aggregation of nanoparticles. | 08-01-2013 |
20130209369 | NANOPARTICLES BASED ON GADOLIIUM COORDINATION POLYMERS AS HIGHLY SENSITIVE T1 MRI CONTRAST AGENTS - An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer. | 08-15-2013 |
20130302255 | NOVEL TARGETED PARAMAGNETIC CONTRAST AGENT - Disclosed are novel, targeting, paramagnetic nanoparticles as contrast agent for magnetic resonance imaging. The compositions of the nanoparticles are composed of self-assembled polyelectrolyte biopolymers having targeting moieties, which can suitable for targeted delivery of paramagnetic ions complexed to the nanoparticles. The nanoparticulate contrast agent can internalize into the targeted tumor cells to realize the receptor mediated uptake, and therefore afford enhanced relaxivity and improved signal-to-noise effect on the examined tissue areas. Methods for making these targeting MRI contrast agents are also provided. | 11-14-2013 |
20130302256 | NANOPARTICULATE MANGANESE MRI CONTRAST AGENTS - This invention discloses a synthetic procedure for preparing nanoparticulate materials of various metal cyanide compounds containing manganese(II) ions in the crystal lattice with the surfaces coated by a hydrophilic compound, and their use as MRI contrast agents with high sensitivity, long blood circulation half lives and low toxicity at low-field and high field MR scanners. | 11-14-2013 |
20140044648 | ACTIVATABLE IMAGING CONTRAST AGENTS - An activatable probe and methods of using the same are provided. The activatable probe includes a superparamagnetic core and a polymeric matrix coating the metal oxide core. A paramagnetic agent encapsulated within the polymeric matrix. The polymeric matrix is configured to release the paramagnetic agent when subjected to a medium having a pH less than a normal physiological pH. | 02-13-2014 |
20140050671 | THERANOSTIC NANOPARTICLE AND METHODS FOR MAKING AND USING THE NANOPARTICLE - Nanoparticle having a poly(beta-amino ester) coating. The poly(beta-amino ester) coating includes one or more therapeutic agents that can be delivered by the particle and one or more anchoring groups that couple the polymer to the nanoparticle's core surface. In certain embodiments, the poly(beta-amino ester) includes one or more polyalkylene oxide groups. The poly(beta-amino ester) can further include a targeting agent to target the nanoparticle to a site of interest and a diagnostic agent that allows for imaging of the particle. Methods for making and using the nanoparticles are also provided. | 02-20-2014 |
20140079644 | CELLULOSE-BASED NANOPARTICLES FOR DRUG DELIVERY - In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided. | 03-20-2014 |
20140099266 | MAGNETIC FLUID NANOSYSTEM - Targeting contrast agent for magnetic resonance imaging (MRI). In preferred embodiments, self-assembled polyelectrolytes coated superparamagnetic iron oxide contrast agent particles are provided, which are labeled with targeting moieties, afforded enhanced relaxivity, improved signal-to-noise and targeting ability. Accordingly, the invention relates to a stable targeting contrast nanosystem applicable for magnetic resonance imaging (MRI) having at least one nanoparticle polyelectrolyte polyanion; a targeting agent conjugated to the biopolymer; and a superparamagnetic ligand. In another embodiment the nanosystem according to the invention has at least two biocompatible and biodegradable nanoparticle polyelectrolyte biopolymer. Particularly, the superparamagnetic iron oxide particles are coated by a polyelectrolyte biopolymer and this system self-assembles with the other biopolymer to produce stable nanosystem for magnetic resonance imaging. Targeting moieties are conjugated to a biopolymer or to the self-assembled biopolymers to realize a targeted delivery of contrast agent. Methods for making these targeting MRI contrast agents are also provided. | 04-10-2014 |
20140105828 | NANOPARTICLES CARING NUCLEIC ACID CASSETTES FOR EXPRESSING RNA - This disclosure relates to nanoparticles carrying nucleic acid cassettes for expressing RNA. In certain embodiments, the disclosure relates to improved methods for targeted delivery and expression of siRNAs in vivo using DNA-based siRNA-expressing nanocassettes and receptor-targeted nanoparticles. In certain embodiments, the disclosure relates to methods of targeted delivery of survivin siRNA expressing nanocassettes which enhance sensitivity of human cancer cells to anticancer agents. | 04-17-2014 |
20140112873 | MELANOCORTIN 1 RECEPTOR LIGANDS AND METHODS OF USE - The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell. | 04-24-2014 |
20140127138 | PH-SENSITIVE IMAGING AGENTS - Composition and method for surface-functionalized SPION-based agents. Such agents can provide highly pH-sensitive MRI contrast in tissue. | 05-08-2014 |
20140147391 | BIOPROBE BASED ON SINGLE-PHASE UPCONVERSION NANOPARTICLES (UCNPs) FOR MULTI-MODAL BIOIMAGING - A bioprobe based on surface-modified single-phase BaGdF | 05-29-2014 |
20140178310 | Polyol and Polyether Iron Oxide Complexes as Pharmacological and/or MRI Contrast Agents - Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods. | 06-26-2014 |
20140234226 | PLASMONIC STABLE FLUORESCENCE SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES AND A METHOD OF SYNTHESIZING THE SAME - The various embodiments herein provide for the engineered multimodal super paramagnetic iron oxide nanoparticles (SPIONs) with a fluorescent dye. The SPIONs comprise fluorescent polymer dye arranged in a gap between a SPION core and a gold shell. The SPIONS are provided with a gold coating. The gap is made up of a polymeric molecule such as 6-arm anthracene terminated. The core of the nanoparticle is made up of a magnetic metal oxide. The method for synthesizing SPIONs involves preparing carboxyl-dextran complex and the SPIONS. The SPIONs are coated with carboxyl-dextran complex. The coated SPIONs coated are subjected to fluorescent polymer and gold nano shell coating. The prepared SPIONs are characterized by light scattering measurement and magnetization measurements. | 08-21-2014 |
20140328768 | Iron Oxide Nanocapsule, Method of Manufacturing the Same, and MRI Contrast Agent Using the Same - Provided is an iron oxide nanocapsule which has extremely excellent water dispersibility, which is very stable in the body and which has very excellent MRI contrast ability, a method of manufacturing the same, and an MRI contrast agent using the same. The method of manufacturing the iron oxide nanocapsule includes the steps of: thermally decomposing an iron complex to prepare hydrophobic ligand-bonded iron oxide nanoparticles; and encapsulating the hydrophobic ligand-bonded iron oxide nanoparticles by a carboxymethyldextrandodecylamine conjugate encapsulation material or a dextran-linoleic acid conjugate encapsulation material to form an iron oxide nanocapsule. | 11-06-2014 |
20150023882 | Aqueous Method for Making Magnetic Iron Oxide Nanoparticles - The invention discloses an aqueous method of making polymer coated superparamagnetic nanoparticles. Nanoparticles made by the method are included in the invention. | 01-22-2015 |
20150064116 | MULTILAYERED MAGNETIC MICELLE COMPOSITIONS AND METHODS FOR THEIR USE - Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide. | 03-05-2015 |
20150139914 | Contrast-Enhancing Agent for Nuclear Magnetic Resonance Imaging Comprising Melanin Nanoparticles Stably Dispersed in Water - The present invention relates to a contrast agent for nuclear magnetic resonance imaging, and more particularly, to a contrast agent for nuclear magnetic resonance imaging containing melanin nanoparticles having a uniform shape and size, thereby providing good dispersibility in water, no cell toxicity, and a long retention time in vivo. | 05-21-2015 |
20160000942 | MRI CONTRAST AGENT INCLUDING T1 CONTRAST MATERIAL COATED ON SURFACE OF NANOPARTICLE SUPPORT - The present invention relates to a magnetic resonance imaging (MRI) T1 contrast agent composition including T1 contrast material coated on the surface of a nanoparticle support. The MRI T1 contrast agent composition of the present invention has excellent T1 spin magnetic relaxation effects by modifying the paramagnetic T1 contrast material on the nanoparticle support having a certain diameter such that the paramagnetic T1 contrast material has a certain thickness or less, and thereby remarkably increasing the surface-to-volume ratio of the T1 contrast material. The present invention provides more precise and clear T1 positive contrast images, and is thus useful for highly reliable image diagnosis. | 01-07-2016 |
20160136307 | NANOPARTICLES FOR MAGNETIC PARTICLE IMAGING APPLICATIONS - One method of preparing a nanoparticle can include decomposing a compound at a high temperature, adding an acid to the solvent to form a reaction mixture, increasing the temperature of the reaction mixture to boiling point of the reaction mixture, and heating the reaction mixture at the boiling point for 60 to 120 minutes to produce the nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic particles imaging. | 05-19-2016 |
20160158387 | COATED MAGNETIC NANOPARTICLES - Disclosed herein are polymer-coated iron oxide magnetic nanoparticles and methods of their manufacture and use. The nanoparticles are coated with a copolymer of poly(maleic anhydride alt-H2C═CH—R1)-polyethylene glycol (PMAR-PEG), wherein R1 is a hydrophobic moiety. The molecular weights of the PMAR and PEG portions of the copolymer, as well as the core diameter of the nanoparticles are selected in order to produce optimal performance for specific applications. Representative applications of the nanoparticles include magnetic particle imaging, magnetic sentinel lymph node biopsy, and magnetic fluid hyperthermia. The disclosed nanoparticles are tools for these methods that provide previously unachieved levels of stability (e.g., via reduced agglomeration) and customizability (e.g., tuned blood circulation half-life in vivo). | 06-09-2016 |