| Entries |
| Document | Title | Date |
|---|
| 20130052140 | FE3O4/TIO2 COMPOSITE NANO-PARTICLE, ITS PREPARATION AND APPLICATION IN MAGNETIC RESONANCE IMAGING CONTRAST AGENTS - This invention provides a Fe | 02-28-2013 |
| 20090304599 | Protein Nanoparticles and the Use of the Same - An object of the present invention is to provide nanoparticles that can easily be delivered to a small site such as a capillary and can be produced using highly biocompatible and safe material. The present invention provides a nanoparticle which contains at least one pharmaceutically active component, a magnetically responsive particle, and a protein. | 12-10-2009 |
| 20130115172 | MAGNETIC NANOPHOSPHOR HAVING CORE/SHELL STRUCTURE AND THE SYNTHETIC METHOD THEREOF - The present invention relates to a nanophosphor and method for synthesizing the same, and provides a nanophosphor containing fluoride-based nanoparticles co-doped with Yb | 05-09-2013 |
| 20090238767 | TARGETING CONTRAST AGENTS OR TARGETING THERAPEUTIC AGENTS FOR MOLECULAR IMAGING AND THERAPY - This invention discloses a method of synthesizing targeting contrast agents for molecular imaging and targeting diagnosis and therapy, targeting contrast agents and targeting therapeutic agents and their use. | 09-24-2009 |
| 20130129632 | Quantum dot materials, methods for making them, and uses thereof - The disclosure provides quantum dot materials, compositions and methods useful in the treatment of various disorders. In particular, the disclosure provides cadmium-free and lead-free quantum dots. | 05-23-2013 |
| 20130129633 | MULTIMODAL NANOPARTICLES FOR NON-INVASIVE BIO-IMAGING - Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging. | 05-23-2013 |
| 20110195030 | NANOPARTICLE COMPOSITIONS COMPRISING LIQUID OIL CORES - Nanocapsule and nanoemulsion particle compositions having improved physical and pharmacological properties are provided. The nanocapsule or nanoemulsion particle composition can comprise a pharmaceutically acceptable liquid oil phase, a surfactant, and optionally a co-surfactant. The liquid oil phase can comprise a monoglyceride, a diglyceride, a triglyceride, a propylene glycol ester, or a propylene glycol diester. In certain embodiments, the nanocapsule or nanoemulsion particle composition can be lyophilized and subsequently re-hydrated without increasing the mean particle size and/or adversely affecting the potency or efficacy of a therapeutic agent (e.g., paclitaxel) present in the nanocapsules or nanoemulsion particles. | 08-11-2011 |
| 20080260648 | Pharmaceutical Preparation Containing Magnetic Vesicular Particles, Manufacturing Method Thereof and Diagnostic Therapeutic System - A pharmaceutical preparation containing magnetic vesicular particles is disclosed, wherein the magnetic vesicular particles each include magnetic microparticles within a lipid membrane, an organic compound having at least two groups selected from the group consisting of a hydroxyl group, a carboxyl group, a carbamoyl group, an amino group, a mercapto group, a sulfo group, a dithio group, a thiocarboxyl group and a dithiocarboxyl group is bonded to the magnetic microparticle, and the magnetic vesicular particles satisfy the following equation: | 10-23-2008 |
| 20100119458 | Compositions Containing Metal Oxide Particles and Their Use - A composition of metal oxide nanoparticles in which individual nanoparticles comprises a core that optionally is coated and the metal oxide comprises a metal oxide lattice in which 5 there are two, three, four or more different kinds of metal ions: A) one of these metal ions is selected among lanthanide ions (typically ions of elements 57-B 71), and) at least one, two, three or more of the other different kinds of metal ions is selected among 10) i transition metal ions of elements of Groups 3b-7b, 8, 1b, 2b other than the lanthanide b ions of elements 57-71, and/or A) lanthanide ions other than the kind of lanthanide ion selected in A. typical metal ion of (A) is Gd3+, of (B.a) is Fe3+ and of (B.b) is Tb3+. 1 5A v method for coating core forms of the particles, and the use of the particles for visualizing various kinds of biological material, e.g. by magnetic resonance, are also provided. | 05-13-2010 |
| 20110200534 | T1-T2 Dual Modal MRI Contrast Agents - The present invention relates a T1-T2 dual-modal MRI (magnetic resonance imaging) contrast agent, comprising (a) a first layer consisting of T1 contrast material; (b) a second layer consisting of T2 contrast material; and (c) a separating layer which is present in a space between the first layer and the second layer, and inhibits a reciprocal interference between T1 contrast material and T2 contrast material, and a heat-generating composition and a drug delivery composition having the same. The T1-T2 dual-modal contrast agent of the present invention may generate both T1 and T2 signal and thus observe the signal complementarily, resulting in accurate diagnosis through reduction of misdiagnosis. Further, T1 and T2 MR imaging may be simultaneously obtained by simple operation within the same MR imaging device, enabling to remarkably reduce a diagnosis time and diagnosis cost. In addition, the particle constituting the T1-T2 dual-modal contrast agent of the present invention may be applied to hyperthermia and drug delivery systems. | 08-18-2011 |
| 20120107246 | METHOTREXATE-MODIFIED NANOPARTICLES AND RELATED METHODS - Methotrexate-modified nanoparticles that target tumors, compositions that include the nanoparticles, methods of imaging tissues using the nanoparticles, and methods for treating tissues using the nanoparticles. | 05-03-2012 |
| 20090047220 | CONTRAST MEDIUM FOR ADMINISTRATION TO A PATIENT FOR MAGNETIC RESONANCE IMAGING - An exemplary contrast medium for administration to a patient for magnetic resonance imaging is shown. The contrast medium includes: a plurality of carbon nanospheres; and an iron containing nano-particle embedded in each of the carbon nanospheres. | 02-19-2009 |
| 20110200533 | COMPOUNDS FOR THE DIAGNOSIS OF DISEASES ASSOCIATED WITH VCAM EXPRESSION - The present invention relates to a compound of the following general formula (I): | 08-18-2011 |
| 20080206150 | Nanoparticles for Imaging Atherosclerotic Plaque - Atherosclerosis is an inflammatory disease of the arterial walls and represents a significant health problem in developed nations. Described is a targeted Magnetic Resonance Imaging (MRI) contrast agent for in vivo imaging of early stage atherosclerosis. Early plaque development is characterized by the influx of macrophages, which express a class of surface receptors known collectively as the scavenger receptors (SR). The macrophage scavenger receptor class A (SRA) is highly expressed during early atherosclerosis. The macrophage SRA therefore presents itself as an ideal target for labeling of lesion formation. By coupling a known ligand for the scavenger receptor, dextran sulfate, to a MRI contrast agent, early plaque formation can be detected in vivo. Targeted MR contrast agents offer a unique opportunity to visualize early plaque development in vivo with high sensitivity and resolution, allowing or early diagnosis and treatment of atherosclerosis. | 08-28-2008 |
| 20090110642 | METHOD FOR THE PRODUCTION OF BIO-IMAGING NANOPARTICLES WITH HIGH YIELD BY EARLY INTRODUCTION OF IRREGULAR STRUCTURE - Methods of preparing bio-imaging nanoparticles having high dispersibility in an aqueous solution, biocompatibility, and targetability with high yield, by early introduction of an irregular structure are disclosed. | 04-30-2009 |
| 20100278748 | NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING - Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group. | 11-04-2010 |
| 20100135912 | MAGNETOTACTIC BACTERIA MRI POSITIVE CONTRAST ENHANCEMENT AGENT AND METHODS OF USE - Magnetic resonance imaging (MRI) is enhanced by contrast agents such as superparamagnetic iron-oxide (SPIO) particles that resemble magnetite particles produced by magnetotactic bacteria. | 06-03-2010 |
| 20080311048 | Imaging Agent - The invention provides a conjugate comprising an iron containing colloidal particle, the particle being conjugated to one or more sugar targeting moieties. The conjugate is useful as a contrast agent in medical imaging, particularly in magnetic resonance imaging (MRI). The agents of the present invention may cross the blood brain barrier and so may be particularly useful in the monitoring or diagnosis of conditions affecting the brain. | 12-18-2008 |
| 20090123384 | METHOD FOR MAGNETIC RESONANCE IMAGING USING STIMULUS INDUCED ROTARY SATURATION WITH A CONTRAST AGENT - A method and system for producing an image of a subject with a magnetic resonance imaging (MRI) system, in which the presence of a contrast agent is detected using a spin-lock pulse sequence, is described. More specifically, a contrast agent that induces saturation of magnetic resonance signals responsive to a spin-lock condition is administered to a subject. A spin-lock condition is subsequently established to saturate spins in proximity to the contrast agent. Image data is then acquired with an imaging pulse sequence and images indicative of the presence of the contrast agent are reconstructed. | 05-14-2009 |
| 20090060844 | METHOD AND CONTRAST AGENT FOR IMAGING A PROSTATE TUMOR - In a method for imaging a prostate tumor in which a contrast agent that can be distributed via the circulatory system is administered to the patient, the contrast agent contains at least one type of biomarkers which are bound to a ferromagnetic particle and specifically bind to a target molecule typical of the tumor and formed within the tumor or in a tissue adjacent to the tumor. The imaging ensues with the use of magnetic resonance tomography. | 03-05-2009 |
| 20100166666 | NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING - Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety. | 07-01-2010 |
| 20120034169 | NITRIC OXIDE-RELEASING PARTICLES FOR NITRIC OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS - The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications. | 02-09-2012 |
| 20100254911 | MULTIMODAL NANOPARTICLES FOR NON-INVASIVE BIO-IMAGING - Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging. | 10-07-2010 |
| 20100226862 | MICROCAPSULE AND METHOD FOR MAGNETIC RESONANCE IMAGING TO LOCALIZE BLOOD - Microcapsule for injection into the bloodstream of a patient before a magnetic resonance acquisition pertaining to the bloodstream, include a magnetic resonance marking substance (in particular with at least one isotope associated with a specific resonant frequency) inside the microcapsule and an outer membrane that is impermeable to the marking substance. The microcapsule is overall biodegradable. | 09-09-2010 |
| 20120195835 | TUMOR TISSUE-SELECTIVE BIO-IMAGING NANOPARTICLES - A bio-imaging nanoparticle is composed of a core nanoparticle, a bonding layer having organic ligands, surfactants and polyoxyalkylene derivatives of fatty acid ester, and veiling the core nanoparticle, and functional molecules, wherein the organic ligands are bound to a surface of the core nanoparticle, the surfactants are bound to a portion of the surface of the core nanoparticle to which the organic ligands are not bound, the polyoxyalkylene derivatives of the fatty acid ester are introduced in an empty space between the organic ligands and the surfactants of the bonding layer, and the functional molecule is bound to a second terminal end opposite to a first terminal end of both terminal ends of the organic ligand, the first terminal end of the organic ligand being bound to a shell of the core nanoparticle. | 08-02-2012 |
| 20100297025 | Novel compositions magnetic particles covered with gem-bisphosphonate derivatives - The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: | 11-25-2010 |
| 20090104124 | Paramagnetic Complexes with Pendant Crown Compounds Showing Improved Targeting- Specificity as MRI Contrast Agents - Potential magnetic resonance imaging (MRI) contrast agents that are functionalized with crown compounds have been synthesized, and show target-specificity to the kidney and liver, along with excellent water solubility, high MR intensity enhancement efficiency, long resident lifetime, low dosage requirement, low cytotoxicity and prolonged excretion rate. | 04-23-2009 |
| 20100278749 | NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING - Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group. | 11-04-2010 |
| 20090068114 | Noninvasive Thermometry Monitoring System - A noninvasive thermometry monitoring system for determining a temperature of tissue to which hyperthermia treatment is administered is disclosed. The monitoring system may incorporate magnetic nanoparticles having known moments such that once exposed to an alternating magnetic field, the magnetic nanoparticles increase in temperature. Imaging systems can disclose the magnetic nanoparticles within a patient. The temperature of the magnetic nanoparticles can be determined by comparing the magnetic nanoparticle with known temperatures for that type of magnetic nanoparticle. The image of the magnetic nanoparticles may be compared with surrounding tissue to determine the temperature of the surrounding tissue that is exposed to hyperthermia treatment. | 03-12-2009 |
| 20110104074 | METHODS FOR TARGETED CANCER TREATMENT AND DETECTION - A method for treating a cancer is provided that comprises identifying a subject in need of treatment for a cancer and administering to the subject a composition that is comprised of a plurality of a ligand for a luteinizing hormone-releasing hormone receptor and a plurality of a chemotherapeutic agent, where each ligand and each chemotherapeutic agent are conjugated to a nanoparticle. Further provided are methods for detecting a cancer in a subject that comprise administering to a subject an imaging agent comprised of a plurality of a ligand for a luteinizing hormone-releasing hormone receptor conjugated to a nanoparticle. | 05-05-2011 |
| 20110104073 | Iron/Iron Oxide Nanoparticle and Use Thereof - The present invention is a nanoparticle composition composed of an iron core with an iron oxide shell which is optionally coated with a micro-emulsion. The disclosed nanoparticle compositions are disclosed for use in hyperthermia treatment and imaging of cancer. | 05-05-2011 |
| 20120201759 | TUNABLE MULTISCALE STRUCTURES COMPRISING BRISTLY, HOLLOW METAL/METAL OXIDE PARTICLES, METHODS OF MAKING AND ARTICLES INCORPORATING THE STRUCTURES - Hierarchical nanostructures and methods of fabrication. The structures include particles having a metal oxide outer shell with metal oxide wires extending from the outer shell. A multiscale structure according to the invention has particles above and below a critical size wherein the particles above the critical size have wires extending from the surface. These structures may be fabricated from a mixture prepared of relatively smaller metal particles having a size threshold below a threshold for nanowire formation and of relatively larger metal particles having a size above the threshold for nanowire formation. The mixture is oxidized at a selected temperature and for a selected time whereby the relatively smaller particles sinter and nanowires grow on the relatively larger particles thereby creating tunable hierarchical structures with metal-to-metal contact between the particles. | 08-09-2012 |
| 20100303730 | Methods of making iron-containing nanoparticles - A method of making iron-containing nanoparticles (e.g., magnetite nanoparticles) that includes contacting an iron-containing precursor with a reducing agent at a temperature less than 200° C. and allowing the mixture to react to form magnetite nanoparticles. | 12-02-2010 |
| 20110165086 | IRON OXIDE NANOPARTICLES AS MRI CONTRAST AGENTS AND THEIR PREPARING METHOD - Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T | 07-07-2011 |
| 20110135577 | Superparamagnetic nanoparticles IN MEDICAL THERAPEUTICS and manufacturing method THEREOF - The successful transfer of therapeutic agents such as genetic materials (e.g. nucleic acid) or drug into living cells is the most important issue depending on the development of the delivery carrier. A method for manufacturing superparamagnetic nanoparticles in medical therapeutics is described to develop nano-sized calcium phosphate (CaP) mineral was rendered magnetic as delivery vehicle. The CaP-based magnetized nanoparticles (NPs) were possessed superparamagnetic property by hetero-epitaxial growth of magnetite on the CaP crystallites and also showed no harm to the cultured cells and elicited no cytotoxicity. The magnetized CaP was demonstrated to have good plasmid DNA binding affinity or drug carrying capacity. It significantly increased the expression of gene transfection and efficiency in delivery to mesenchymal stem cells (MSCs) under exogenous magnetic field. According to the above facts, this newly-synthesized magnetized CaP NPs has great potential as a novel non-viral targeted delivery vehicle to be applied for medical applications. | 06-09-2011 |
| 20110256066 | METHOD FOR PREPARING ENGINEERED MG DOPED FERRITE SUPERPARAMAGNETIC NANO PARTICLE EXHIBITING AC MAGNETIC INDUCTION HEATING AT HIGH TEMPERATURE AND MG DOPED FERRITE SUPERPARAMAGNETIC NANO PARTICLES ENGINEERED BY THE METHOD - The present invention relates to a method for preparing a ferrite superparamagnetic nano particle engineered by magnesium doping, and a technique for applying it to hyperthermia cancer cell treatment and the heat shock protein (HSP) self-defense mechanism. | 10-20-2011 |
| 20100166665 | NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING - Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety. | 07-01-2010 |
| 20100166664 | NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING - Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety. | 07-01-2010 |
| 20090220431 | MAGNETIC RESONANCE IMAGING CONTRAST AGENTS CONTAINING WATER-SOLUBLE NANOPARTICLES OF MANGANESE OXIDE OR MANGANESE METAL OXIDE - The present invention relates to a manganese-containing metal oxide nanoparticle-based magnetic resonance imaging (MRI) contrast agent, which is characterized in that: The core of it comprises 1 to 1000 nm-sized manganese-containing metal oxide nanoparticles which include MnO a (0| 09-03-2009 | |
| 20110110865 | CHELATROS, PARAMAGNETIC CHELATES THEREOF AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) - The present invention relates to chelators, in particular to chelators which are capable of forming complexes, i.e. paramagnetic chelates, with paramagnetic metal ions. The invention also relates to said paramagnetic chelates, said paramagnetic chelates linked to other molecules and their use as contrast agents in magnetic resonance imaging (MRI). | 05-12-2011 |
| 20100233094 | PERFLUOROCARBON NANO-EMULSION CONTAINING QUANTUM DOT NANOPARTICLES AND METHOD FOR PREPARING THE SAME - The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields. | 09-16-2010 |
| 20120003160 | Macrophage-Enhanced MRI (MEMRI) in a Single Imaging Session - Methods for performing macrophage-enhanced MRI, utilizing a macrophage imaging agent, in a single imaging session are provided. The macrophage imaging agent may be an ultrasmall superparamagnetic iron oxide particle. One embodiment includes administering a macrophage imaging agent to the subject during an administration session then allowing a passage of time sufficient for accumulation of the agent in macrophages of the subject. Subsequently, in a single imaging session, a macrophage-enhanced magnetic resonance image is acquired to target macrophages and a different magnetic resonance image is acquired to target physiological phenomenon other than macrophages. Additional embodiments provide methods wherein the acquisition of a different magnetic resonance image is achieved by vascular-enhanced MRI protocols or perfusion-enhanced MRI protocols, or combinations thereof. Further embodiments provide methods for utilizing acquired images in assessment of treatment of disease. | 01-05-2012 |
| 20120058053 | CARBON NANOHORN MRI CONTRAST AGENTS - A contrast agent characterized in that each of carbon nanohorns forming a carbon nanohorn aggregate has an opening at the side wall or tip, wherein a metal M (at least one metal selected from among paramagnetic metals, ferromagnetic metals, and superparamagnetic metals) or a compound of the metal M is incorporated in or dispersed on each of the carbon nanohorns. A contrast agent characterized in that it contains a Gd oxide. There is provided a contrast agent, which can be mass-produced easily, and satisfies the requirement of low toxicity and enables microscopic diagnoses when used for MRI. A contrast agent characterized in that is contains a carbon nanohorn aggregate. | 03-08-2012 |
| 20120156142 | DIAGNOSTIC AGENT COMPOSITION AND ASSOCIATED METHODS THEREOF - A diagnostic agent composition is provided which comprises a nanoparticle composition and a pharmaceutically acceptable carrier or excipient. The nanoparticle composition comprises a nanoparticulate metal oxide and a phosphorylated polyol, wherein the phosphorylated polyol comprises at least two phosphate groups and one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. The disclosure provides detailed guidance on methods of making and using such diagnostic agent compositions. The diagnostic agent compositions provided by the present invention are useful as contrast agents for medical diagnostic imaging techniques such as magnetic resonance (MR) imaging and X-ray imaging. The diagnostic agent composition may be administered to a subject via a variety of techniques, among them injection, inhalation, and ingestion. | 06-21-2012 |
| 20120156141 | NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF - A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging. | 06-21-2012 |
| 20100008862 | Fluorescent magnetic nanoprobes, methods of making, and methods of use - Embodiments of the present disclosure provide for nanoprobes, methods of imaging, methods of imaging a target, methods of making nanoprobes, and the like. | 01-14-2010 |
| 20100092394 | Multimeric Particles - The invention provides multimeric particle comprising metal-containing particles covalently bonded to one another by linker groups wherein at least some of said linker groups are cleavable. The invention further provides a contrast agent comprising said multimeric particles, along with a method of improving contrast of an image using said contrast agent. | 04-15-2010 |
| 20120219508 | CELLULOSE-BASED NANOPARTICLES FOR DRUG DELIVERY - In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided. | 08-30-2012 |
| 20120076737 | METHOD OF USING CT/MRI DUAL MODALITY CONTRAST AGENT - Nanoparticles are used as a contrast agent for magnetic resonance imaging and computed tomography. Each of the nanoparticles includes a metal alloy core and a plurality of hydrophilic molecules covalently bound to the surface of the metal alloy core. Also disclosed is a method for using the contrast agent. | 03-29-2012 |
| 20090246143 | NON-RADIOACTIVE TRACEABLE METAL ISOTOPE-ENRICHED NANOPARTICLES AND METHOD OF THEIR USE FOR DETERMINING BIODISTRIBUTION - Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes. | 10-01-2009 |
| 20100047180 | Iron/Iron Oxide Nanoparticle and Use Thereof - The present invention is a nanoparticle composition composed of an iron core with an iron oxide shell which is optionally coated with a micro-emulsion. The disclosed nanoparticle compositions are disclosed for use in hyperthermia treatment and imaging of cancer. | 02-25-2010 |
| 20110104072 | TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS - The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents. | 05-05-2011 |
| 20080213189 | Multifunctional metal-graphite nanocrystals - Disclosed are nanocrystals comprising metals and metal alloys, which are formed by a process that results in a layer of graphite in direct contact with the metallic core. The nanocrystals may be used in vivo as MRI contrast agents, X-ray contrast agents, near IR (NIR) heating agents, drug delivery, protein separation, catalysis etc. The nanocrystals may be further functionalized with a hydrophilic coating, e.g., phospholipid-polyethylene glycol, which improves in vivo stability. The process comprises chemical vapor deposition of metals adsorbed onto silica as a fine powder, in conjunction with a carbon containing gas, which coats the metal particles. The silica is then etched away. Preferred metals include iron, gold, cobalt, platinum, ruthenium and mixtures thereof, e.g., FeCo and AuFe. The process permits control of the alloy compositions, size, and other characteristics. | 09-04-2008 |
| 20090060846 | NANOPARTICLES HAVING REACTIVE ESTER GROUPS COVALENTLY COUPLED THERETO AND RELATED METHODS - A particle having a core and a surface to which are covalently coupled a plurality of reactive ester groups. Methods for using the particle to prepare a particle having one or more of a plurality of a targeting agent, a diagnostic agent, or a therapeutic agent covalently coupled thereto. | 03-05-2009 |
| 20090060845 | DIAGNOSIS SUBSTANCE FOR APPLICATION IN A METHOD TO DIAGNOSIS PATHOLOGICAL TISSUE AND A METHOD FOR PRODUCTION OF SUCH A DIAGNOSIS SUBSTANCE - A diagnosis substance for application in a method for diagnosis of pathological tissue, contains at least one virus population with virus particles specifically binding to target molecules typical of a specific pathological tissue, with a label that is detectable with the use of a detection device being bound to the virus particles. In a method for production of such a diagnosis substance, the principle of directed biological evolution is applied. | 03-05-2009 |
| 20080299047 | Method for preparation of water-soluble and dispersed iron oxide nanoparticles and application thereof - The present invention relates to a process for preparing water-soluble and dispersed iron oxide (Fe | 12-04-2008 |
| 20080299046 | METHODS FOR CONTROLLING SURFACE FUNCTIONALITY OF METAL OXIDE NANOPARTICLES, METAL OXIDE NANOPARTICLES HAVING CONTROLLED FUNCTIONALITY, AND USES THEREOF - Methods for controlling surface functionality of metal oxide nanoparticles, nanoparticles having controlled surface functionality, and uses thereof are described herein. Methods for controlling the surface functionality of a metal oxide nanoparticle are can include attaching a ligand to a metal oxide nanoparticle, where the ligand can include a functional portion that is capable of forming an irreversible bond with an object at a site that is complementary to the functional portion without reacting with other reactive sites that may be present. Moreover, metal oxide nanoparticles having versatile ligands can include an anchoring portion that binds to the surface of the metal oxide nanoparticle and a functional portion that is capable of forming an irreversible bond with an object at a site that is complementary to the functional portion without reacting with other reactive sites that may be present. Uses thereof can include cancer detection, electronics, cosmetics, cellular delivery carriers, magnetic storage media, drug delivery carriers, nanocomposite formation for improved mechanical properties, and the like. | 12-04-2008 |
| 20100233093 | Magnetic resonance imaging contrast agent with paramagnetic-inositol phosphates complexes - Disclosed are novel MRI contrast agents and imaging methods using the same. The novel MRI contrast agent comprises a chelating molecule with at least two phosphate groups coordinated with at least one paramagnetic substances. | 09-16-2010 |
| 20110274624 | CONTRAST AGENTS IN POROUS PARTICLES - MRI imaging compositions are disclosed comprising non-chelated MRI contrast agents in the pores of at least one porous microparticle or nanoparticle. The compositions of the invention have been found to exhibit increased relaxivity and therefore, enhanced MRI imaging. The non-chelated contrast agents include T1 contrast agents, such as those including Gd(III) or Mn(II). Methods of MRI imaging and methods of making the compositions are also disclosed. | 11-10-2011 |
| 20120087868 | NANOPARTICLE-LOADED CELLS - The invention provides nanoparticle-loaded cells and compositions useful for improved imaging and therapy, for example radio-therapy. The invention also provides methods of manufacture of nanoparticle-loaded cells, methods of administering the nanoparticle-loaded cells, and methods for treatment and/or imaging. | 04-12-2012 |
| 20100215586 | NOVEL METHOD FOR PREPARING NANOPARTICLES COVERED WITH A GEM-BISPHOSPHONATE STABILIZING LAYER COUPLED TO HYDROPHILIC BIODISTRIBUTION LIGANDS - A novel method for preparing nanoparticles for medical imaging, including a metal core, an organic stabilizing layer containing gem-bisphosphonate compounds and at least one hydrophilic biodistribution ligand. | 08-26-2010 |
| 20080305048 | Self-Assembling Nanoparticle Conjugates - This invention relates to magnetic nanoparticle conjugates and related compositions and methods of use. | 12-11-2008 |
| 20130017155 | DUAL CT/MRI NANOPARTICLE CONTRAST AGENT - The invention relates to a new tungsten-iron-Ferritin nanoparticle and uses thereof in imaging. | 01-17-2013 |
| 20110158915 | NANOSHELLS WITH TARGETED ENHANCEMENT OF MAGNETIC AND OPTICAL IMAGING AND PHOTOTHERMAL THERAPEUTIC RESPONSE - A particle and a method of manufacturing a particle that includes a complex, a paramagnetic entity, and a silica layer that encapsulates the paramagnetic entity and the complex. The dielectric layer of the particle encapsulates the complex and the paramagnetic entity such that at least a portion of an outer surface of the complex is covered by the paramagnetic entity. In addition, the particle may or may not include a fluorescent entity encapsulated within the dielectric layer. Also, the particle may or may not include a targeting entity covalently bonded to the silica layer. | 06-30-2011 |
