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356 - Optics: measuring and testing


356311000 - With sample excitation (e.g., burning)

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Class / Patent application numberDescriptionNumber of patent applications / Date published
356318000 Monochromatic (e.g., laser) 49
20100141941OPTICAL SPECTROMETER ELEMENT HAVING NON-SPHERICAL MIRRORS - The invention relates to a spectrometer for analysing the optical emission of a sample, having an excitation source, an entrance gap and a dispersive element, which fans out the spectrum of the light generated in the excitation source in a plane, and having solid body sensors with one or more lines, which are arranged in the region of the focal curve of the beam path in order to evaluate the spectral information, wherein the sensors are arranged above or below the plane and the spectral emission is deflected onto the sensors by mirrors and focused, wherein the reflecting surface of the mirrors is aspherically formed in a direction of curvature.06-10-2010
20090109435DEVICE CONTAINING NON-BLINKING QUANTUM DOTS - An optoelectronic device including two spaced apart electrodes; and at least one layer containing ternary core/shell nanocrystals disposed between the spaced electrodes and having ternary semiconductor cores containing a gradient in alloy composition and wherein the ternary core/shell nanocrystals exhibit single molecule non-blinking behavior characterized by on times greater than one minute or radiative lifetimes less than 10 ns.04-30-2009
20100073675ATOMIC ABSORPTION SPECTROPHOTOMETER - With the measurement unit (03-25-2010
20090079979SPECTROPHOTOMETER - A spectrophotometer is provided capable of reducing the influence of the vibration as much as possible when a wavelength dispersion element is rotationally driven and capable of increasing the analysis accuracy. When a fluorescence signal is obtained from the fluorescence detector, the central control unit A/D converts the fluorescence signal at sampling intervals of T03-26-2009
20090116007QUANTUM DOT CONJUGATES IN A SUB-MICROMETER FLUIDIC CHANNEL - A nanofluidic channel fabricated in fused silica with an approximately 500 nm square cross section was used to isolate, detect and identify individual quantum dot conjugates. The channel enables the rapid detection of every fluorescent entity in solution. A laser of selected wavelength was used to excite multiple species of quantum dots and organic molecules, and the emission spectra were resolved without significant signal rejection. Quantum dots were then conjugated with organic molecules and detected to demonstrate efficient multicolor detection. PCH was used to analyze coincident detection and to characterize the degree of binding. The use of a small fluidic channel to detect quantum dots as fluorescent labels was shown to be an efficient technique for multiplexed single molecule studies. Detection of single molecule binding events has a variety of applications including high throughput immunoassays.05-07-2009
20090040518Apparatus, method and computer program for spectroscopic measurements and analysis - The present invention relates to a spectroscopic method and associated apparatus and computer program for measuring and analysing intensities of fluorescent molecules excited by an energy pulse. The method includes the steps of: a) generating a transient state build-up in the fluorescent molecules by means of an excitation pulse, within which pulse repetitive excitation-emission cycles are induced in the fluorescent molecules between their ground, typically singlet (So) and excited, typically singlet (SO states, resulting also in transition from S] to the transient state, b) relaxation of population of the transient state by transition back to the ground state in a time period following directly after the excitation pulse, c) determination of the transient state population by recording the fluorescence. The invention is characterised by varying pulse characteristics from one sequence of pulses to the next so as to circumvent the need of time-resolution in the detection.02-12-2009
20130162991APPARATUS AND METHOD FOR TRANSPORTING AN AEROSOL - An apparatus can include ablation chamber body having a transmission window and defining an accommodation region configured to accommodate a target that is movable relative to the transmission window. An aerosol transmission conduit is configured to transport an aerosol produced within the accommodation region to a sample receiving region of an analysis system along a substantially straight transport path.06-27-2013
20110019186CLUSTERS OF MICRORESONATORS FOR CAVITY MODE OPTICAL SENSING - A method for sensing a target object using optical mode excitations in microresonators, comprises: preparing at least one cluster including at least two microresonators; obtaining some first spectra of the cluster; adsorbing the target object on a surface of the cluster; obtaining some second spectra of the cluster; and sensing the target object by comparing a lineshape of the first spectra with a lineshape of the second spectra.01-27-2011
20080239310FIBER OPTICAL SENSOR WITH OPTICAL RESONATOR - A fiber optical sensor includes a light source, a detector and an optical resonator having a multimode optical fiber and two reflective layers respectively provided adjacent to or on ends of the optical fiber. Excitation light from the light source is coupled into the optical resonator through a transparent hole formed in one of the reflective layers. An evanescent wave extends outside the optical fiber in the active region of the optical fiber. The fluorescent light generated by a fluorescent material excited by the evanescent wave in response to the presence or concentration of the analyte in a sample to be assayed is detected by the detector. The light beam is reflected back and forth between the first and second reflective layers many times within the optical resonator whereby the strength of the fluorescent light is significantly increased thereby resulting in a significantly signal amplification.10-02-2008
20090316148SPECTROPHOTOMETER - Disclosed herein is a spectrophotometer. The spectrophotometer includes a CPU having a signal prediction part and a comparison/calculation part. The signal prediction part predicts the strength of an output signal from a photodetection unit during the next period based on the strength of the output signal from the photodetection unit. The comparison/calculation part compares a reference value, which defines the limit value of electrical current passing through a photomultiplier tube, of the strength of an output signal from an AD converter with a predicted value predicted by the signal prediction part. In a case where the predicted value exceeds the reference value, a voltage applied to the photomultiplier tube is calculated so that the strength of an output signal from the photodetection unit during the next period does not exceed the reference value. An applied voltage control part is configured to perform applied voltage control based on an applied voltage value calculated by the comparison/calculation part when the predicted value of the strength of an output signal from the photodetection unit during the next period exceeds the reference value.12-24-2009
20100033719METHOD AND DEVICE FOR OPTICAL ANALYSIS OF A TISSUE - The invention relates to a method and device for analyzing a tissue (02-11-2010
20090153854Method and Apparatus for Spectroscopic Analysis - A method and apparatus for obtaining the gas-phase electromagnetic radiation spectrum of a liquid sample, which apparatus comprises an analysis chamber having an inlet and an outlet, wherein the inlet and analysis chamber are adapted such that, in use, liquid sample is drawn into the inlet through capillary action and vapourised therein, the vapourised liquid sample remaining in the gas phase within the inlet and the analysis chamber The apparatus may be attached to a process conduit or vessel containing a source of the liquid for analysis, making it suitable for collecting on-line spectra.06-18-2009
20110007311METHOD AND ARRANGEMENT FOR THE TIME-RESOLVED SPECTROSCOPY USING A PHOTON MIXING DETECTOR - The present invention relates to a solution for time-resolved spectroscopy, wherein the sample to be analyzed is illuminated by a modulated light source, and the spectrum reflected therefrom is recorded in a time-resolved manner and evaluated. In the method according to the invention for time-resolved spectroscopy, a sample to be analyzed is irradiated by a modulated light source having short light pulses, and the radiation emitted by the sample is represented via imaging optical elements and a spectral-selective element on a sensor disposed in the image plane, and the signals thereof are evaluated by a control and regulating unit, and/or stored. The sensor disposed in the image plane is a PMD sensor, which in addition to the intensity values also determines the running times of the radiation emitted by the sample, and forwards the same to the control and regulating unit. Although PMD sensors were originally intended for object recognition, particularly in traffic, the use thereof in many other technical fields is conceivable and advantageous. The solution provided herein describes the use of PMD sensors in spectroscopy, particularly for the time-resolved analysis of samples. However, the use of PMD sensors is also possible in Raman spectrometry, or for the measurement of luminescence, such as for differentiating phosphorescence and fluorescence light.01-13-2011
20090303473Method of monitoring and controlling of mixing processes - A method for determining the degree of mixing between components in a mixing process, the method including the steps of: a) mixing at least two components and at least two luminescent materials to form a mixture, wherein the luminescent materials are added to the mixture separately from each other, and wherein each luminescent material has a uniquely detectable luminescence emission wavelength; b) detecting emitted luminescence from a sample of the mixture, wherein the emitted luminescence includes different luminescence intensities at the uniquely detectable luminescence emission wavelengths of the luminescent materials; c) wherein the ratio of luminescence intensities and/or the absolute or relative intensities of luminescence at the uniquely detectable luminescence emission wavelengths is indicative of the degree of mixing between the components.12-10-2009
20090296084BOREHOLE MEASUREMENTS USING A FAST AND HIGH ENERGY RESOLUTION GAMMA RAY DETECTOR ASSEMBLY - A gamma ray detector assembly for a borehole logging system that requires the measure of gamma radiation with optimized gamma ray energy resolution and with fast emission times required to obtain meaningful measurements in high radiation fields. The detector assembly comprises a lanthanum bromide (LaBr3) scintillation crystal and a digital spectrometer that cooperates with the crystal to maximize pulse processing throughput by digital filtering and digital pile-up inspection of the pulses. The detector assembly is capable of digital pulse measurement and digital pile-up inspection with dead-time less than 600 nanoseconds per event. Pulse height can be accurately measured (corrected for pile-up effects) for 2 pulses separated by as little as 150 nanoseconds. Although the invention is applicable to virtually any borehole logging methodology that uses the measure of gamma radiation in harsh borehole conditions, the invention is particularly applicable to carbon/oxygen logging.12-03-2009
20090262344Measuring Equipment for quality of water - The present invention relates to equipment for measuring water quality using a fish or a water flea, an more particularly, to equipment for measuring water quality in which small organisms such as killifish (or medaka) or water flea are put into test chamber having a plurality of divided sections and behavior of the fishes or the water fleas accommodated in the test chamber is observed while continuously flowing water of a river or a water zone to be examined through the test chamber, thereby finding out and measuring existence of toxic element or harmful substance included in the water to be examined.10-22-2009
20090103083Acoustic and optical illumination technique for underwater charaterization of objects/environment - The invention provides a method for acoustically and optically characterizing an immersed object of interest by generating a serial plurality of acoustic and optical illumination pulses through a liquid. In addition to the spectral analyses/imaging of objects/environment made possible by the white-light illumination, a target material can be ablated, generating an ionized plume to spectrally identify the target's constituent atoms.04-23-2009
20080212090FLUOROMETER WITH LOW HEAT-GENERATING LIGHT SOURCE - This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a plurality of sample containers, such as capped PCR tubes in a standard titer tray. The fluorometer of the present invention further comprises an optical path between each LED and its correspondingly positioned container, and another optical path between each fluorescing sample within the positioned container and an optical signal sensing means. The instrument can be computer controlled.09-04-2008
20110199609METHOD AND DEVICE FOR CHARACTERIZING MICROSCOPIC ELEMENTS - A method and device is provided for characterizing microscopic elements. A source signal may be chopped by means of microsystems of opto-electromechanical elements (MOEMS), which gives rise to temporal modulation of the excitation signals. The method of characterizing microscopic elements involves propagating a dispersed light source signal, spatially chopping the spectrum of the source signal into at least two excitation signals having predetermined wavelengths λ08-18-2011
20100284004MEASURING ARRANGEMENT FOR AN OPTICAL SPECTROMETER - The invention relates to a measuring arrangement for an optical spectrometer, in particular a photon density wave spectrometer, having a measuring chamber, which can be loaded with a sample to be measured, and a coupling-in/coupling-out device which is configured to receive excitation light from a light source and couple it into the sample to be measured in the measuring chamber and to receive measuring light formed in the sample to be measured on account of the excitation light which has been coupled in and to emit said measuring light to a detection device, wherein the coupling-in/coupling-out device has an optical switching device and a plurality of light guide elements which couple to the latter, have a respective optical waveguide and can be connected according to at least one selectable measuring configuration using the optical switching device in order to couple in the excitation light and receive the measuring light according to the at least one selectable measuring configuration, and wherein outputs of the plurality of light guide elements are positioned according to a spiral arrangement in the viewing direction of the outputs.11-11-2010
20080309933SCANNING SPECTROPHOTOMETER FOR HIGH THROUGHPUT FLUORESCENCE DETECTION - A fluorescence spectrophotometer having an excitation double monochromator, a coaxial excitation/emission light transfer module, and an emission double monochromator. Each monochromator includes a pair of holographic concave gratings mounted to precisely select a desired band of wavelengths from incoming broadband light without using other optical elements, such as mirrors. Selected excitation light is directed into a sample well by a light transfer module that includes a coaxial excitation mirror positioned to direct excitation light directly to the bottom of a well of a multi-well plate. Fluorescence emission light that exits the well opening is collected by a relatively large coaxial emission mirror. The collected emission light is wavelength selected by the emission double monochromator. Selected emission light is detected by a photodetector module.12-18-2008
20080291444Method of Spectroscopy - A method of multidimensional spectroscopy has a controllable excitation source parameter and comprises controlling said controllable parameter to excite a vibrational mode of the sample, generating a homodyne reflected signal from the sample and obtaining a spectrum of the sample from the reflected signal.11-27-2008
20080316481APPARATUS FOR ANALYZING AND SORTING BIOLOGICAL PARTICLES - The invention provides an apparatus including (a) a frame having a boundary plane; (b) a flow chamber supported by the frame, the flow chamber placed a distance from the boundary plane; (c) a radiation source, the radiation source directed away from the flow chamber and away from the exterior side of the boundary plane, and (d) a first reflective surface placed to direct a radiation beam in a path crossing the boundary plane to the flow chamber; (e) one or more reflective surfaces placed to direct a radiation beam from the radiation source to the first reflective surface, the path from the radiation source to the flow chamber being at least 1.5 times the distance from the flow chamber to the boundary plane.12-25-2008
20090086204Fluorescence Correlation Microscopy with Real-Time Alignment Readout - This invention relates to a confocal fluorescence correlation microscope with real-time alignment read out. With this instrument it is possible to do confocal imaging together with the particle size determination at a chosen location in the specimen. In particular, this invention relates to a detector module with a fixed aperture and detection electronics that can be conveniently connected to an existing confocal or multiphoton microscope, near the base of the objective lens of the microscope. This detector splits a part of the signal and uses it to generate a spot on the confocal image. This shows the spot where an FCS measurement can be carried out, and the same signal can then be used to perform a fluorescence correlation measurement after parking the excitation beam of the confocal to that spot. No alignment step is necessary for obtaining the measurement.04-02-2009
20090161103OPTICAL SYSTEM AND METHOD FOR INSPECTING FLUORESCENTLY LABELED BIOLOGICAL SPECIMENS - A system for imaging a fluorescently labeled sample is presented, The system comprises a capsule, which is a closable structure made of a material isolating the inside of the capsule from its surrounding environment, and which has a support stage for receiving the sample and carrying it thereinside during the imaging; and an optical device at least partly accommodated inside the capsule and operable to illuminate the sample with incident radiation to excite a fluorescent response of the sample, detect the fluorescent response, and generate data indicative thereof.06-25-2009
20090128806SPECTRAL IMAGE PROCESSING METHOD, SPECTRAL IMAGE PROCESSING PROGRAM, AND SPECTRAL IMAGING SYSTEM - A spectral image processing system and method of performing robust unmixing on measurement noise. Based on an observed spectral image acquired from a specimen and emission spectral data of each of plural materials contained in the specimen, a contribution of each of the plural materials to the observed spectral image is unmixed by a process, including an evaluating step of evaluating reliability of each component of the observed spectral image based on a predicted spectral image of the observed spectral image, and a reflecting step of reflecting a result of the evaluation in a content of the unmixing.05-21-2009
20080316482Optical scanning configurations, systems, and methods - Methods and optical systems for scanning of a target sample, including methods and systems using a low mass scan head. The present invention also relates to methods and systems for performing sample assays, and for producing and measuring optical responses and signatures.12-25-2008
20110222059Systems, devices, and methods including a dark-field reflected-illumination apparatus - Systems, devices, and methods are described that modulate a specimen-background dark-field micrograph contrast.09-15-2011
20090066947METHOD AND APPARATUS FOR INTERACTIVE HYPERSPECTRAL IMAGE SUBTRACTION - Disclosed is a method of obtaining a spectral image of each of a plurality of predetermined chemical species in a sample, comprising: (a) illuminating the sample with a first plurality of photons to produce a second plurality of photons; (b) collecting the second plurality of photons and producing a plurality of images of the sample therefrom, each of said images comprising a frame consisting essentially of a plurality of pixels; (c) for each of the predetermined chemical species, identifying at least one wavelength range at which the chemical specie exhibits a unique absorption of radiation; (d) identifying at least one wavelength range at which none of the predetermined chemical species exhibits an absorption of radiation; (e) in each of the image frames, identifying which of the pixels do not contain any of the predetermined chemical species; (f) in each of the image frames, identifying which of the pixels contain only a first the predetermined chemical species; (g) repeating the previous step for each of the predetermined chemical species; (h) in each of the image frames, identifying which of the pixels contain more than one of the predetermined chemical species; (i) for each pixel that contains more than one of the predetermined chemical species, separating the contribution of each predetermined chemical species; and (j) composing separate spectral images of each of the predetermined chemical species in the sample. Also disclosed are apparati for performing these methods, comprising: (a) an illumination source for illuminating the sample with a first plurality of photons to form a second plurality of photons; (b) an optical device for receiving and directing the second plurality of photons to an imaging device; (c) an imaging device for forming a plurality of images of the sample; and (d) a processor in communication with the imaging device.03-12-2009
20090225311PROBE APPARATUS AND TERAHERTZ SPECTROMETER - A probe apparatus includes a first focusing lens and a second focusing lens. The first focusing lens is arranged on a surface of a base to which a terahertz excitation beam is applied, the surface being opposite to the surface to which terahertz excitation beam is applied, with the lens axis deviated from the center of a point at which the terahertz excitation beam is applied. The second focusing lens is arranged on a surface of a base to which a terahertz detected beam is applied from a source of the terahertz excitation beam, the surface being opposite to the surface to which the terahertz detected beam is applied, with the lens axis deviated from the center of a point at which the terahertz detected beam is applied, in a direction opposite to the direction in which the lens axis of the first focusing lens is deviated.09-10-2009
20100265502Spatially and Spectrally Parallelized Fiber Array Spectral Translator System and Method of Use - System and method for spatially and spectrally parallelized FAST. A sample is illuminated to thereby produce interacted photons. The photons are passed through a filter and received at a two-dimensional end of a FAST device wherein said FAST device comprises a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack so as to effectively convert a two-dimensional array of optical fibers into a curvilinear field of view, and wherein said two-dimensional array of optical fibers is configured to receive said photons and transfer said photons out of said fiber array spectral translator device and to a spectrograph through said one-dimensional fiber stack wherein said one-dimensional fiber stack comprises at least two columns of fibers spatially offset in parallel at the entrance slit of said spectrograph. The photons are then detected at a detector to thereby obtain a spectroscopic data set representative of the sample.10-21-2010
20100157294SUB-MICROMETER FLUIDIC CHANNEL FOR MEASURING PHOTON EMITTING ENTITIES - A nanofluidic channel fabricated in fused silica with an approximately 500 nm square cross section was used to isolate, detect and identify individual quantum dot conjugates. The channel enables the rapid detection of every fluorescent entity in solution. A laser of selected wavelength was used to excite multiple species of quantum dots and organic molecules, and the emission spectra were resolved without significant signal rejection. Quantum dots were then conjugated with organic molecules and detected to demonstrate efficient multicolor detection. PCH was used to analyze coincident detection and to characterize the degree of binding. The use of a small fluidic channel to detect quantum dots as fluorescent labels was shown to be an efficient technique for multiplexed single molecule studies. Detection of single molecule binding events has a variety of applications including high throughput immunoassays.06-24-2010
20100165338Time-Resolved Spectroscopy System and Methods for Multiple-Species Analysis in Fluorescence and Cavity-Ringdown Applications - A time-resolved spectroscopy system employing a time-division multiplexing optical device with no dispersive optical elements to perform lifetime and concentration measurements in multi-species samples, is disclosed. Some examples include fluorescence and cavity ring-down spectroscopy. The system is unique in its compactness and simplicity of operation. In one embodiment, the system makes use of only one photo-detector and an efficient linear regression algorithm. The system offers a measurement time for multiple species measurements of less than 1 s. The system can also be used to perform fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy. Four methods to de-convolve a multi-component, exponentially decaying optical signal such as obtained with the system disclosed here, are presented. These methods may be applied to the measurement of fluorescence decay lifetimes and cavity ring-down times, the latter used extensively for the measurement of gas and trace-gas concentrations in complex mixtures, via absorption spectroscopy.07-01-2010
20100128265APPARATUS AND METHOD FOR MEASURING THE SIGNAL FROM A FLUORESCING NANODROP CONTAINED BY SURFACE TENSION - Apparatus and method for measuring the fluorescence of nanodrop liquid samples is described in which the sample is held by surfa tension between two anvil surfaces (05-27-2010
20090116008Spectral observation method and spectral observation system - A proposition of the present invention is to acquire necessary data without any chasm in an observation of a specimen containing plural kinds of substances of which exciting wavelengths are different. Accordingly, a spectral observation method of the present invention, irradiating light to the specimen containing plural kinds of substances (RFP, GFP, and so on) of which exciting wavelengths are different, and detecting spectra of light emitted from the specimen, the spectral observation method sequentially acquires spectral data of substances from the one of which exciting wavelength is long while switching a wavelength of the irradiated light among respective exciting wavelengths of the plural kinds of substances, and excludes the exciting wavelength of the substance corresponding to the spectral data to be acquired from detection wavelengths of the spectra each when acquiring the spectral data of the spectral data of the respective substances.05-07-2009
20090161104PLASMON RESONANT PARTICLES, METHODS AND APPARATUS - A method and apparatus for interrogating a target having a plurality of plasmon resonant particles (PREs) distributed in the target are disclosed. In the method, a field containing the target is illuminated, and one or more spectral emission characteristics of the light-scattering particles in the field are detected. From this data, an image of positions and spectral characteristic values in the field is constructed, allowing PREs with a selected spectral signature to be discriminated from other light-scattering entities, to provide information about the field. Also disclosed are a novel PRE composition for use in practicing the method, and a variety of diagnostic applications of the method.06-25-2009
20100302536DATA COLLECTION SYSTEM AND METHOD FOR A FLOW CYTOMETER - A system for a flow cytometer that collects data for a sample prepared with a plurality of fluorochromes that includes a fixed gain detection system that collects data for a plurality of fluorescence channels, fluorochrome compensation factors for a plurality of fluorochromes types, and a computer system that has an interface that gathers fluorochrome information of the sample and an analysis program that compensates for spectral spillover in the collected data. The fixed gain detection system preferably has a wide dynamic range. A fluorochrome compensation factor preferably remains constant for a fixed gain detection system. The analysis program preferably uses the fluorochrome compensation factors to compensate for spectral spillover.12-02-2010
20100302537SPECTROSCOPY DEVICE AND METHOD FOR ITS IMPLEMENTATION - The invention relates to a spectroscopy device (12-02-2010
20100302538SPECTROSCOPIC PROBE AND METHOD FOR DETECTING AN INHOMOGENEITY - The invention relates to a spectroscopic probe (12-02-2010
20110001965METHODS, DEVICES AND KITS FOR PERI-CRITICAL REFLECTANCE SPECTROSCOPY - Spectroscopy apparatuses oriented to the critical angle of the sample are described that detecting the spectral characteristics of a sample wherein the apparatus consists of an electromagnetic radiation source adapted to excite a sample with electromagnetic radiation introduced to the sample at an angle of incidence at or near a critical angle of the sample; a transmitting crystal in communication with the electromagnetic radiation source and the sample, the transmitting crystal having a high refractive index adapted to reflect the electromagnetic radiation internally; a reflector adapted to introduce the electromagnetic radiation to the sample at or near an angle of incidence near the critical angle between the transmitting crystal and sample; and a detector for detecting the electromagnetic radiation from the sample. Also, provided herein are methods, systems, and kits incorporating the peri-critical reflectance spectroscopy apparatus.01-06-2011
20080278722Fluorescence detection enhancement using photonic crystal extraction - Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent scattering effects, attributed to leaky photonic crystal eigenmodes (resonance modes). The photonic crystal simultaneously exhibits resonance modes which overlap both the absorption and emission wavelengths of the fluorophore. A significant enhancement in fluorescence intensity from the fluorophores on the photonic crystal surface is demonstrated.11-13-2008
20090033931Optical Measurement Apparatus and Method - An optical modulation spectroscopy system comprises a probe beam source and components for directing the probe beam at a sample. It also may comprise a modulated pump beam source and components for directing a modulated pump beam at the sample. A dispersive system may disperse the reflected probe beam into constituent wavelengths to provide dispersed beams. A detector array may detect multiple dispersed reflected probe beams and processes a signal corresponding to each. Thus, measurement may be multiplexed for very fast performance.02-05-2009
20110211193PRESSURE CONTROLLED SPECTROSCOPIC HEATING VALUE SENSOR - A method and system for measuring a physical property of a fluid in which light having wavelengths in the near-infrared is directed into a test cell containing the fluid and portions of the light not absorbed by the fluid and passing out of the cell are spatially dispersed by wavelength, forming a light spectrum that is projected onto a detector. The light spectrum is digitized and inputted into a data processing unit in which it is compared to the actual spectrum of the light source stored in the system to determine the absorbance spectrum of the fluid. The system is spectrally calibrated by identifying known spectral features of the fluid absorbance spectrum. To correct for deviations in the original light source spectrum, a calibration method in which the pressure of the fluid in the test cell is alternated between a first positive pressure and a second positive pressure is employed. Upon determination of the absorbance spectrum of the fluid, the physical property of interest of the fluid is determined by comparing the absorbance spectrum to a plurality of spectra located within an on-board database.09-01-2011
20090323059SHG Quantification of Matrix-Related Tissue Dynamic and Disease - A microscope for optical imaging of high optical scattering coefficient biological tissue, comprising an optical excitation source for irradiating a scan area of the sample and generating optical emissions, wherein the sample has a first face facing away from the source and a second face facing the source. A two dimensional element for scanning the light over the sample; a focusing element having a numerical aperture NAi to focus the light onto the sample; a first optical condenser to collect light from the first face, the collected light comprising source transmitted light and first optical emission generated in the sample, the condenser having a NA2 larger than NAi; an optical filter to block the transmitted source light; an aperture with a size corresponding to the irradiated area of the sample, the aperture at the conjugate image position of the sample generated by the condenser; and an optical detector collecting light from the first face for detecting the first optical emission from the scan area.12-31-2009
20100053607FLUORESCENCE POLARIZATIO IMAGING DEVICE AND METHOD - The present invention is directed to a novel multi-spectral exogenous fluorescence polarization imaging technique that enables rapid imaging of large tissue fields. The imaging device includes a tunable monochromatic light source and a CCD camera. Linear polarizers are placed into both the incident and collected light pathways in order to obtain fluorescence polarization or/and anisotropy image. To acquire exogenous fluorescence image, fluorescent contrast agents are delivered to a target tissue.03-04-2010
20110255085SPECTROMETER, SPECTROMETRY, AND SPECTROMETRY PROGRAM - A spectroscopic measurement apparatus 10-20-2011
20100027003Spectroscopic analysis methods - A spectroscopic analysis method in which spectral data of mixtures obtained from a plurality of points on a sample surface are resolved into component spectra and concentrations. A new alternating least squares multivariate curve resolution technique is presented which iteratively resolves the components. The technique starts from an initial estimate that the spectral values of a first component of the sample are all equal (an ‘empty model’), and resolves that component. Then successive further components are iteratively resolved, from initial ‘empty model’ estimates of those components and from previously resolved spectra. In the common case where the main component is present in nearly pure form in the data set, this empty modelling technique results in more accurate resolution of the components. This is due to the ability of the technique to resolve the pure spectra of minor components without modelling concentrations of the main component into them.02-04-2010
20090046286Cancer detection by optical analysis of body fluids - The optical analysis of body fluids is a method of determining the relative concentration of certain bio-molecules in blood and urine samples by fluorescent spectroscopy. The relative concentration of these bio-molecules serves as a marker or screening test to assess the presence and stage of cancer in some organ or tissue of the body, and in some cases, the presence of particular types of cancer in the body. The bio-molecules include various species of porphyrin, flavins (including flavin mononucleotide[FMN], flavin adeno dinucleotide [FAD], and riboflavin), bile components (including biliverdin and bilirubin), tyrosine, tryptophan, and NAD(P)H. The fluorescent spectroscopy techniques include determining intensity maxima in the emission spectra at particular excitation wavelengths characteristic of the bio-molecules, determining intensity maxima in the excitation spectra at particular emission wavelengths characteristic of the bio-molecules, and synchronous scanning of the excitation and emission spectra while maintaining particular offsets in the wavelengths.02-19-2009
20090141272Optical instrument comprising multi-notch beam splitter - An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.06-04-2009
20090168061FLUORESCENCE DETECTION APPARATUS - A fluorescent detection apparatus relates to an analysis technique for qualitatively detecting or quantifying biomolecules by producing an evanescent field on a surface of a substrate, exciting fluorescently labelled biomolecules on the substrate surface in the evanescent field, and detecting the resultant fluorescent light emitted from the biomolecules. The fluorescent detection apparatus has a configuration in which a well is provided in a surface opposing to a sample substrate of a prism, the well is filled with a matching liquid, and the matching liquid is filled between the sample substrate and the prism, thereby improving operability and providing a stable evanescent field.07-02-2009
20100067002IMAGE OBTAINING METHOD AND IMAGE OBTAINING APPARATUS - Emitting illumination light and auxiliary light having a wavelength range different from that of the illumination light onto an observation target simultaneously, obtaining an image formed of reflection light of the illumination light and reflection light of the auxiliary light reflected from the observation target, calculating, with respect to each pixel of the obtained image signal, estimated spectroscopic data in the wavelength range of the auxiliary light using a value of the image signal and estimated matrix data in the wavelength range of the auxiliary light stored in advance, obtaining quasi reflectivity information reflecting a reflectivity of the observation target in the wavelength range of the auxiliary light based on the estimated spectroscopic data in the wavelength range of the auxiliary light, and generating a special image based on the quasi reflectivity information.03-18-2010
20110102787OPTICAL MICROSCOPY WITH PHOTOTRANSFORMABLE OPTICAL LABELS - An apparatus includes a position-sensitive detector to detect intensities of radiation as a function of position on the detector, and an optical system, characterized by a diffraction-limited resolution volume, adapted for imaging light emitted from activated and excited phototransformable optical labels (“PTOLs”) in a sample onto the position sensitive-detector. A first light source provides activation radiation to the sample to activate a subset of the PTOLs that are distributed in the sample with a density greater than an inverse of the diffraction-limited resolution volume of the optical system. A second light source provides excitation radiation to the sample to excite a portion of the PTOLs in the subset of the PTOLs. A controller controls one both of the activation radiation and the excitation radiation provided to the sample such that a density of PTOLs in the portion of the PTOLs is less than the inverse of the diffraction-limited resolution volume.05-05-2011
20120300205METHOD OF NORMALIZING A FLUORESCENCE ANALYZER - A method of normalizing an analyzer response value of a fluorescence analyzer is provided. The method includes measuring an excitation spectrum of the analyzer and measuring an emission sensitivity spectrum of the analyzer. Next, a normalization factor based at least in part upon the excitation spectrum of the analyzer and the emission sensitivity spectrum of the analyzer is determined. The sample is then analyzed to obtain an uncorrected analyzer response value. A normalized analyzer response value is calculated based at least in part upon the uncorrected analyzer response value and the normalization factor.11-29-2012
20080297793SMALL OBJECT IDENTIFYING DEVICE AND ITS IDENTIFYING METHOD - A small object identifying device and its identifying method according to which a large number of small objects can be identified. In one embodiment, the device includes a dispersion region section which disperses a large quantity of several kinds of small objects which are labeled by a combination of the presence/absence or measure of label elements of several kinds. A measuring device distributes and associates kinds of said label elements to two or more measurement points and measures the presence/absence or the measure of said label elements of the kinds which have been associated with respective measurement points. An identifying section associates the measurement results measured at each measurement point to thereby identify said small objects.12-04-2008
20080297792FLUORESCENCE DETECTING MODULE FOR MICROREACTION AND FLUORESCENCE DETECTING SYSTEM HAVING THE SAME - A fluorescence detecting module for detecting fluorescence in a microchamber and a fluorescence detecting system. The fluorescence detecting module includes a light source irradiating excitation light a collimating lens condensing excitation light irradiated, a dichroic mirror selectively transmitting or reflecting the light according to a wavelength thereof, an objective lens condensing excitation light selected to be irradiated on a sample in a microchamber and condensing fluorescence generated in the microchamber, a focusing lens focusing fluorescence selected by the dichroic mirror, and a fluorescence detecting element detecting fluorescence focused. The fluorescence detecting system for a microfluid chip in which microchambers are arranged, includes a frame, at least one fluorescence detecting module, a holder supporting the fluorescence detecting module, a driver allowing the holder to make a reciprocating motion along a direction in which the microchambers are arranged, and a guide supporting the holder to be moved and guiding the movement.12-04-2008
20100149531APPARATUS AND METHOD FOR OBJECT AUTHENTICATION USING TAGGANT MATERIAL - An object authentication system for authenticating an object includes a taggant material applied to the object; a database storing data related to the excitation-emission properties of the taggant material and to an identity of the object; and an authentication reader. The authentication reader includes an excitation source for emitting light for exciting the taggant material, an emission detection device for detecting light emission of the excited taggant material, and a processing unit for analyzing the detected light emission, comparing the detected light emission profile with data stored in the database, and thereby verifying the identity of the object. The taggant material includes a fluorescent material and the taggant material is applied to the object by being mixed into the raw material of the object, being integrated with a portion of the object, or being attached to the object by an adhesive material. A method for authenticating an object is also provided.06-17-2010
20080246961Biosensors with porous dielectric surface for fluorescence enhancement and methods of manufacture - Biosensors are disclosed which include a surface for binding to sample molecule to the biosensor in the form of a porous, thin film of dielectric material, e.g., TiO10-09-2008
20080231851Systems and methods for material authentication - Systems and methods for authentication of materials used in imaging members and assemblies. Authentication of imaging materials ensure that compatible components are being used with the imaging members and assemblies. Embodiments provide a system and method for efficiently detecting whether materials being used in the imaging members and assemblies are compatible and authentic materials authorized for such uses.09-25-2008
20080225290MINIATURIZED FLOURESCENCE ANALYSIS SYSTEM - According to embodiments of the present invention, a fluorescence analysis system includes a light emitting diode to excite a fluorophor sample for analysis. The system includes an LED driver that pulses the LEDs in the array with currents in excess of maximum rated current at low duty cycles. One embodiment receives a first drive current at a light emitting diode (LED), emits excitation light having a first color and/or first wavelength band in response to the first drive current, receives a second drive current at the LED, and emits excitation light having a second color and/or second wavelength band in response to the second drive current, wherein at least one of the drive currents is greater than a nominal drive current for the LED.09-18-2008
20080218752Chemometric Analyzer with a Spatial Radiation Modulator Having a Plurality of Radiation Filters - A chemometric analyzer for analyzing a plurality of analytes. The analyzer disperses radiation by wavelength along an encoding axis. The analyzer includes a spatial radiation modulator having a plurality of radiation filters. Each radiation filter modulates the intensity of a corresponding spectral component in the radiation.09-11-2008
20130100443DEVICE FOR SPLITTING LIGHT INTO COMPONENTS HAVING DIFFERENT WAVELENGTH RANGES AND METHODS OF USE - A prism including a substrate faceted to provide a plurality of flat surfaces, wherein at least two of the plurality of surfaces, each including a filter coating, form at least two filter surfaces, wherein each filter surface selectively permits passage of a predetermined wavelength and reflects remaining wavelengths along an optical path towards another of the plurality of surfaces, optionally another filter surface, wherein an angle of incidence of each of the plurality of surfaces along the optical path is equal or nearly equal. An apparatus incorporating the prism and its use for splitting a light spectrum into a plurality of wavelengths or wavelength ranges.04-25-2013
20080204745Thin-Film Polarization Sample Cell For Biological And Chemical Agents And A Method Of Sampling - The present invention provides sample cells for use in thin film fluorescence polarization systems, methods of loading sample cells, and methods of detecting biological or chemical agents using thin film fluorescence polarization.08-28-2008
20080198379Device For Detection And Measurement Of A Target Compound Such As A Food Toxin - Apparatus comprising a holder for a sample which comprises a packing or coating capable of immobilising or isolating a target compound in a layer or band, an excitation unit that emits radiation that excites fluorescence in a target compound or derivatised target compound immobilised or isolated in the packing or coating, or in another moiety stimulated by the target compound, a detection unit that is sensitive to radiation emitted by a fluorescing target compound, derivative or target compound-stimulated moiety and outputs a signal proportional to the amount of radiation detected, means for relatively moving the sample cartridge and the detection unit whereby the radiation may be sensed and a processing unit that converts the output of the detector unit into a readable value related to the amount of target compound immobilised in the layer or band.08-21-2008
20080198378Method And Device For Diagnosing Chronic Fatigue Syndrome (Cfs) By Using Near Infrared Spectrum - The present invention provides a method and device of quantitatively or qualitatively examining and diagnosing chronic fatigue syndrome (CFS) by: irradiating a sample derived from an examinee or other animal with light having a wavelength in a range of 400 nm to 2500 nm or a wavelength in part of the range; detecting reflected light, transmitted light, or transmitted and reflected light to obtain an absorption spectral data; and analyzing absorbance at all measurement wavelengths or at specific wavelengths in the absorption spectral data by using an analytical model prepared beforehand.08-21-2008
20090073434SURFACE PLASMON-ENHANCED NANO-OPTIC DEVICES AND METHODS OF MAKING SAME - A nanostructured optical device includes a metal film or a plurality of metal islands having an array of a plurality of openings having a width that is less than at least one first predetermined wavelength of incident radiation to be provided onto the film or the islands. The metal film or islands are configured such that the incident radiation is resonant with at least one plasmon mode on the metal film or metal islands.03-19-2009

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