Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


With Raman type light scattering

Subclass of:

356 - Optics: measuring and testing

356300000 - BY DISPERSED LIGHT SPECTROSCOPY

Patent class list (only not empty are listed)

Deeper subclasses:

Entries
DocumentTitleDate
20110181878Method and System for Raman Detection - A method and a system for Raman detection are provided. Embodiments of the method include providing a fluid analyte at a signal-enhancing structure including a V-groove for Raman signal enhancement of the analyte. The invention further provides a Raman detection system which includes the above signal-enhancing structure and a Raman spectrometer.07-28-2011
20100149530MICROSTRUCTURED BODY, PROCESS FOR PRODUCING THE MICROSTRUCTURED BODY, SENSOR DEVICE, AND RAMAN SPECTROMETRY DEVICE - In order to simply produce a microstructured body in which metal particles are arranged so as to be fixed to depressions of a metal substrate having at a surface a structure of protrusions and the depressions, a process for producing the microstructured body includes the steps of: (A) preparing a metal substrate 11 with a surface having a structure of protrusions and depressions; (B) forming a metal film 21 on the surface of the metal substrate 11, where the metal film 21 contains as the main component a metal different from the constituent metal of the metal substrate 11; and (C) annealing the metal film so that the constituent metal of the metal film is coagulated into particles.06-17-2010
20100085566Surface enhanced raman spectroscopy on optical resonator (e.g., photonic crystal) surfaces - Highly sensitive Surface Enhanced Raman Spectroscopy (SERS) sensors are described in the form of a optical resonator and a metal nanostructure deposited on surface of the optical resonator. In one embodiment the optical resonator is in the form of a photonic crystal, but other optical resonators are contemplated. Examples are described in which the resonant near-fields of a large-area replica molded photonic crystal efficiently couples light from a laser to dielectric-metal “post-cap” nanostructures deposited on the photonic crystal surface by a glancing angle evaporation technique, achieving a high SERS enhancement factor. Other constructions are also contemplated a metal nanostructure formed on a dielectric support deposited on the photonic crystal, including a metallic film deposited over close-packed surface of nanospheres, arrays of metallic nanotriangles, metallic nanorods, metallic nanohelices, arrays of metallic nanospheres, and roughened metal surfaces.04-08-2010
20110194107SYSTEM AND METHOD FOR MONITORING STRUCTURES - A technique facilitates the monitoring of elongate structures. An elongate structure is combined with an optical fiber deployed along the structure. An interrogation system is operatively joined with the optical fiber to input and monitor optical signals to determine any changes in parameters related to the structure.08-11-2011
20110194106 METHOD AND APPARATUS TO PREPARE A SUBSTRATE FOR MOLECULAR DETECTION - An device for Raman spectroscopy such as surface enhanced Raman spectroscopy (SERS) is disclosed herein. Various embodiments may be utilized to prepare a SERS substrate using several deposition techniques such as pulsed laser deposition. Some embodiments optimize coverage, volume, or elements of SERS active metals. The method is a single step inexpensive method for preparing a SERS active substrate. In some embodiments a coating layer underneath the SERS active metals is utilized for additional enhancements.08-11-2011
20080291443Cars microscopy and spectroscopy using ultrafast chirped pulses - Linear chirped pulses in a Raman excitation scheme provide selective excitation of only one target transition (single mode) in a molecule without disturbing any other transitions or molecules. Selectivity is guaranteed by the adiabaticity of the pulse excitation, which allows manipulation by only a resonant mode while leaving all of the other modes unperturbed. This in turn allows for enhanced imaging or spectroscopic analysis of a sample that contains one or more of the molecules.11-27-2008
20130077094Compact, Low Cost Raman Monitor For Single Substances - Apparatus for performing Raman analysis may include a laser source module, a beam delivery and signal collection module, a spectrum analysis module, and a digital signal processing module. The laser source module delivers a laser beam to the beam delivery and signal collection module. The beam delivery and signal collection module delivers the laser source beam to a sample, collects Raman scattered light scattered from the sample, and delivers the collected Raman scattered light to the spectrum analysis module. The spectrum analysis module demultiplexes the Raman scattered light into discrete Raman bands of interest, detects the presence of signal energy in each of the Raman bands, and produces a digital signal that is representative of the signal energy present in each of the Raman bands. The digital signal processing module is adapted to perform a Raman analysis of the sample.03-28-2013
20090122310METHOD OF MAKING MICROARRAYS - Provided is a method of making microarrays that includes providing a substrate with discrete first microfeatures that have a first profile, and depositing vapor-coated materials onto the first microfeatures to form second microfeatures having a second profile that is substantially different from the first profile. Also provided is a method of adding a replication material to the vapor-coated microfeatures to form a mold. Microarrays made by this method can be used as substrates for surface-enhanced Raman spectroscopy (SERS).05-14-2009
20090122308PHOTONIC BANDGAP FIBERS - Included among the many structures described herein are photonic bandgap fibers designed to provide a desired dispersion spectrum. Additionally, designs for achieving wide transmission bands and lower transmission loss are also discussed. For example, in some fiber designs, smaller dimensions of high index material in the cladding and large core size provide small flat dispersion over a wide spectral range. In other examples, the thickness of the high index ring-shaped region closest to the core has sufficiently large dimensions to provide negative dispersion or zero dispersion at a desired wavelength. Additionally, low index cladding features distributed along concentric rings or circles may be used for achieving wide bandgaps.05-14-2009
20130038872Probe - A probe includes an optical system which irradiates a site of a biological tissue and receives light emitted from the site, and an imaging device. The imaging device is disposed ahead of the optical system closer to the end of the probe. The probe rotates the incident direction of the light and the imaging direction of the imaging device around a rotation axis directed to the longitudinal direction of the probe while fixing an angle between the incident direction and the imaging direction. The optical system receives the light from the site which always falls in the field of view of the imaging device, or brought with a time lag into the field of view of the imaging device as a result of rotation, the light being incident in the direction normal to, or inclined away from the rotation axis.02-14-2013
20130038869Surface enhanced Raman scattering spectroscopic waveguide - A waveguide for use with surface-enhanced Raman spectroscopy is provided that includes a base structure with an inner surface that defines a cavity and that has an axis. Multiple molecules of an analyte are capable of being located within the cavity at the same time. A base layer is located on the inner surface of the base structure. The base layer extends in an axial direction along an axial length of an excitation section. Nanoparticles are carried by the base layer and may be uniformly distributed along the entire axial length of the excitation section. A flow cell for introducing analyte and excitation light into the waveguide and a method of applying nanoparticles may also be provided.02-14-2013
20130038871METHOD FOR DETECTING A RESONANT NONLINEAR OPTICAL SIGNAL AND DEVICE FOR IMPLEMENTING SAID METHOD - The invention relates to a method and a device for detecting a resonant non-linear optical signal induced in a sample (02-14-2013
20130038870SURFACE-ENHANCED RAMAN SCATTERING SUBSTRATE AND A TRACE DETECTION METHOD OF A BIOLOGICAL AND CHEMICAL ANALYTE USING THE SAME - The invention provides a surface-enhanced Raman scattering substrate and a trace detection method of a biological and chemical analyte using the same. The substrate includes: a substrate having a periodic nanostructure; a reflection layer formed on the substrate; a dielectric layer formed on the reflection layer; and a metal thin film layer formed on the dielectric layer.02-14-2013
20100045978SPECTRAL SIGNATURE EXTRACTION FOR DRUG VERIFICATION AND IDENTIFICATION - Systems and methods perform signature extraction from an acquired spectrum of a pharmaceutical. An acquired spectrum of the pharmaceutical is measured using a spectrometer. The acquired spectrum is obtained from the spectrometer using a processor. A system-response function of the spectrometer is removed from the acquired spectrum using the processor. An intensity of the acquired spectrum is normalized to a predetermined scale using the processor. Fluorescence is removed from the acquired spectrum using the processor. Finally, an extracted signature of the pharmaceutical is obtained from the remainder of the acquired spectrum using the processor. If the acquired spectrum of the pharmaceutical is measured by the spectrometer through a container holding the pharmaceutical, a spectrum of the container is removed from the remainder of the acquired spectrum to produce the extracted signature of the pharmaceutical using the processor.02-25-2010
20100110423OPTICAL DEVICES AND SYSTEMS USING THEM - Certain examples described herein are directed to optical devices and systems that include first and second optical elements. In some examples, the first optical element may be configured to pass light received from an excitation source, and the second optical element may be optically coupled to the first optical element and may be configured to reflect incident light from the first optical element back to the first optical element and configured to pass the light reflected from the first optical element. Methods using the devices and systems are also described.05-06-2010
20100321685TYPE SELECTIVE AND POLARIZATION SELECTIVE DEVICE FOR RAMAN SPECTROSCOPY - A type and polarization selective device for Raman spectroscopy includes a set of at least two antennas and a gap at their intersection. First antenna geometry is such that it is configured to resonate, for first or second (different from the first) polarization, at a predetermined stimulation frequency of a material for which Raman scattering is to be studied, or at a Stokes or anti-Stokes frequency corresponding with the material when excited at stimulation frequency. Second antenna geometry is such that it is configured to resonate, for the other of second or first polarization, at the Stokes frequency when the first antenna is configured to resonate at the stimulation or anti-Stokes frequency, or at the anti-Stokes frequency when the first antenna is configured to resonate at the stimulation or Stokes frequency, or at the stimulation frequency when the first antenna is configured to resonate at the Stokes or anti-Stokes frequency.12-23-2010
20100321683Surface enhanced raman scattering nano-tagging particle and method for preparing thereof - There is provided a method for manufacturing a surface enhanced Raman scattering nano-tagging particle, the method including the steps of: introducing silver nanoparticles on the surface of a silica core particle; immobilizing tagging materials and silica shell precursors on the silver nanoparticles; and forming a silica shell surrounding the silica core particle to which the tagging materials and the silica shell precursor are immobilized.12-23-2010
20100110424NANO STRUCTURED SENSING DEVICE FOR SURFACE-ENHANCED RAMAN SCATTERING - A sensing device for surface-enhanced Raman spectroscopy (SERS) includes a substrate, a plurality of nano structures over the substrate, wherein at least one of the nano structures comprises an active SERS nano surface and an adsorption layer on the active SERS nano surface.05-06-2010
20100027002HIGH-SPEED, RUGGED, TIME-RESOLVED, RAMAN SPECTROMETER FOR SENSING MULTIPLE COMPONENTS OF A SAMPLE AND FOR DIAGNOSTICS OF PATHOLOGICAL SKIN CONDITIONS SUCH AS CANCER - A new architecture for implementing a time-resolved Raman spectrometer is 2-3 orders of magnitude faster than current systems. In one embodiment, the invention employs a rotating optical switch to time multiplex an input signal through multiple band-pass filters and into a single optical detector which is electrically activated only when the filtered input light pulse is about to impact it.02-04-2010
20130027698SELF-ARRANGING, LUMINESCENCE-ENHANCEMENT DEVICE FOR SURFACE-ENHANCED LUMINESCENCE - A self-arranging, luminescence-enhancement device 01-31-2013
20130083322NONLINEAR OPTICAL MICROSCOPE AND NONLINEAR OPTICAL MICROSCOPY - Provided is a nonlinear optical microscope capable of improving the spatial resolution. The nonlinear optical microscope includes: an illuminating part for irradiating, through an objective lens, a sample with at least two colors of illumination light beams spatially and temporally overlapping each other; and a detecting part for detecting signal light generated from the sample due to nonlinear optical effect, the signal light resulting from the irradiation of the sample with the at least two colors of illumination light beams, in which the illuminating part irradiates the sample with the two colors of illumination light beams in which at least one of the illumination light beams has a wavefront distribution different from a wavefront distribution of the other one of the illumination light beams.04-04-2013
20120182550WAVEGUIDES CONFIGURED WITH ARRAYS OF FEATURES FOR PERFORMING RAMAN SPECTROSCOPY - Embodiments of the present invention are directed to systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system for performing Raman spectroscopy includes a waveguide layer (102,402,702,902) configured with at least one array of features, and a material (110,410,710,910) disposed on at least a portion of the features. Each array of features and the waveguide layer are configured to provide guided-mode resonance for at least one wavelength of electromagnetic radiation. The electromagnetic radiation produces enhanced Raman scattered light from analyte molecules located on or in proximity to the material.07-19-2012
20130070241ASYMMETRICAL-NANOFINGER DEVICE FOR SURFACE-ENHANCED LUMINESCENSE - An asymmetrical-nanofinger device for surface-enhanced luminescence. The device includes a substrate, and a plurality of nanofingers coupled with the substrate. The plurality of nanofingers includes a primary nanofinger having a primary active-material cap, and a secondary nanofinger having a secondary active-material cap. An average diameter of the primary active-material cap is substantially greater than an average diameter of the secondary active-material cap. The primary nanofinger and secondary nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with an analyte molecule disposed between the primary active-material cap and the secondary active-material cap. A method for fabricating the asymmetrical-nanofinger device, and an optical apparatus including an optical component that includes the asymmetrical-nanofinger device are also provided.03-21-2013
20130050693SPECTROMETER - A spectrometer (02-28-2013
20130050696DETERMINING PERCENT SOLIDS IN SUSPENSION USING RAMAN SPECTROSCOPY - Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a Partial Least Squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.02-28-2013
20130050694RAMAN SPECTROMETER, SENSOR ELEMENT FOR A RAMAN SPECTROMETER AND A METHOD FOR OBTAINING A RAMAN SPECTRUM USING THE SENSOR ELEMENT - A Raman spectrometer includes a light source (02-28-2013
20130050695SURFACE ENHANCED RAMAN SCATTERING (SERS) APPARATUS, METHODS AND APPLICATIONS - Surface enhanced Raman scattering (SERS) substrates may be fabricated using a shadow mask assisted evaporation (SMAE) method to provide for enhanced detection sensitivity with respect to target molecules that are located upon, and sensitized by, the SERS enhanced substrates. Such SERS substrates provide a two dimensional array of repeating nanostructures that may include, but are not limited to nano-pillar, nano-nib, nano-elliptical cylinder and nano-triangular tip nanostructures, any of which may be augmented with gold nanospheres. The particular SERS enhanced substrates in accordance with the embodiments, in particular when augmented with gold nanospheres, provide desirably enhanced sensitivity.02-28-2013
20100134794ANALYZER FOR DETERMINING THE CONCENTRATION, POTENCY AND PURITY OF PHARMACEUTICAL COMPOUNDS - A computer facilitated method of requesting a spectral analysis of a sample having an unknown concentration or purity, performing an energy absorption analysis of the sample to obtain spectral data regarding the analysis and comparing the spectral data to stored spectral data regarding the analyses of the samples having a predetermined concentration and purity to determine the concentration or purity of the sample having an unknown concentration or purity. The spectral analysis is performed on site where the sample is prepared or administered using a portable analytical apparatus and provides a real time report of the concentration or purity of the sample. The apparatus requires only a small sample size.06-03-2010
20090310130METHOD AND SYSTEM FOR ENHANCED REMOTE DETECTION OF LOW CONCENTRATION VAPORS - There is provided a method for detecting a target material, preferably a solid or liquid target material. The method may comprise the steps of targeting a material for analysis, heating the material with a heating source from a remote distance to effectively increase a temperature of the material and to effectively increase a vapor pressure of the material in an environment adjacent to the material, measuring with a sensor the material vapor in the adjacent environment from the remote distance, and detecting the identity of the material using data generated during the measuring step. There is also provided a system for detecting a target material having a low vapor pressure comprising a first energy generating source, a sensor for measuring properties of gaseous materials from a standoff distance, the sensor producing data, and a computer for determining the target material based on the data produced by the sensor.12-17-2009
20090303471Chemical imaging explosives (CHIMED) optical sensor - A system and method of detecting explosive compounds located on a sample. The sample is irradiated with animal-safe ultra-violet radiation generating a fluorescence data set. A fluorescence database is searched based on the fluorescence data set in order to identify a known fluorescence data set. If the searching of the fluorescence database identifies a known fluorescence data set, an area of interest in the sample is identified based on the known fluorescence data set identified in the fluorescence database searching. The area of interest is irradiated with substantially monochromatic radiation to generate a Raman data set of the area of interest. A Raman database is searched based on the Raman data set in order to identify a known Raman data set. An explosive compound in the area of interest is identified based on the known Raman data set identified by searching the Raman database.12-10-2009
20090303472METHODS OF USE FOR SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SYSTEMS FOR THE DETECTION OF BACTERIA - Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting biomolecules of interest, such as a bacterium are provided.12-10-2009
20110007307Two-Photon-Absorption Optical Filter - A tunable optical filter includes a medium configured to perform polarization rotation on a portion of a linearly polarized signal beam having a frequency within a selected frequency band, wherein the medium is circularly birefringent within the frequency band, and wherein the polarization rotation is achieved based on two-photon-absorption. The first stage of the filter transmits a dual transmission line, and a subsequent portion of the filter partions the output of the first stage into two separate transmission channels.01-13-2011
20090040516SPECTROSCOPIC SYSTEM - A spectroscopic system having a coded aperture as a gating device. Light of a Raman scattering may enter the system and encounter a mask gate. The mask may have a matrix of micro mirrors some of which pass light on to a diffraction grating when the gate is on. Some of the mirrors will not pass on light thereby resulting in coded light to the grating. If the gate is off, then no light is passed on to the grating. The grating may pass the coded and spectrally spread light on to a detector array. The array signals representing the light on the array may go to a processor so one can obtain information about the target that emanated the Raman scatter when impinged by a light beam.02-12-2009
20110058164Time resolved single-step protease activity quantification using nanoplasmonic resonator (NPR) sensor - A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.03-10-2011
20130057857IMPEDANCE MATCHING GROUND PLANE FOR HIGH EFFICIENCY COUPLING WITH OPTICAL ANTENNAS - An optical nanoantenna ground plane apparatus and method which enhances electric field intensity, surface-enhanced Raman spectroscopy (scattering). A dielectric spacer layer is disposed between a nanoantenna layer and a metallic ground plane layer. Thickness of the dielectric spacer layer is determined in response to matching metal loss resistance and radiation resistance of the optical nanoantenna layer for a given optical antenna configuration and operating wavelength, such as in response to finite difference time domain (FDTD) simulations which determine dielectric spacer layer thickness when radiation quality factor and absorption quality factor are equal. The inventive ground plane can be implemented for a wide range of optical applications regardless of whether fabrication of the nanoantenna-groundplane combination is fabricated in a top-down or bottom-up sequence.03-07-2013
20130057856FLUID COMPOSITION ANALYSIS MECHANISM, CALORIFIC VALUE MEASUREMENT DEVICE, POWER PLANT AND FLUID COMPOSITION ANALYSIS METHOD - A fluid composition analysis mechanism includes a light source for applying excitation light to a sample fluid at a measurement position, a light receiving unit configured to receive and disperse Raman scattering light generated from the sample fluid irradiated with the excitation light, a Raman scattering light collection optical system configured to collect the Raman scattering light generated at the measurement position and to cause the Raman scattering light to be incident on the light receiving unit, a calculation unit for calculating a composition of the sample fluid based on an output of the light receiving unit, and a light shielding member arranged on the optical path of the excitation light or on the extended line of the excitation light.03-07-2013
20090268200APPARATUS AND METHOD FOR OBTAINING SPECTRAL INFORMATION - A method of obtaining spectral information comprises initiating at least a first excitation at a first excitation frequency and a second excitation at a second frequency in a surface enhanced sample. The method further comprises varying one of said first and second excitation frequencies, detecting an output signal having an output signal strength and identifying an output signal peak. In addition the method includes correlating the identified output signal with the first and second excitation frequencies to obtain spectral information, in which the surface enhanced sample substrate is configured to enhance the field corresponding to at least one of the first and second excitation, or output fields initiated in this sample.10-29-2009
20130162989Method for Automatically Calibrating a Raman Spectrum Detection System and Raman Spectrum Detection System - The present disclosure relates to a Raman spectrum detection system, which comprises a light source for emitting excitation light that excites a detected object to emit Raman light; an external light path system for irradiating light emitted from the light source on the detected object and collecting the Raman light emitted by the detected object; a light detection device for receiving the Raman light collected by the external light path system and detecting said Raman light to obtain spectrum data thereof; a control device for controlling the excitation light source to provide the excitation light, controlling the light detection device to detect the Raman light, receiving the spectrum data output from the light detection device, and analyzing said spectrum data to identify the detected object; and an automatic calibration device for holding the standard sample and for automatically calibrating the system. The present disclosure also relates to a method for detecting an object using the Raman spectrum detection system, and a method for automatically calibrating the Raman spectrum detection system.06-27-2013
20130162990SPECTROMETRY DEVICE AND SPECTROMETRY METHOD - A spectrometry device according to an aspect of the present invention is including a light source (06-27-2013
20130162987EXCITATION LIGHT SOURCE FOR RAMAN AMPLIFICATION, RAMAN AMPLIFIER, AND OPTICAL TRANSMISSION SYSTEM - An excitation light source, for Raman amplification, includes a polarization beam splitter (PBS) for splitting a laser beam from an excitation laser into two polarization components, and a polarization beam combiner (PBC) for combining the two polarization components, and a time difference generator provided between PBS and PBC. The time difference generator generates a difference in propagation time between the two polarization components.06-27-2013
20130162988SUPERIOR ANALYZER FOR RAMAN SPECTRA WITH HIGH ACCEPTANCE CONE, RESOLUTION, TRANSMISSION, QUANTUM EFFICIENCY, AND STRONG BACKGROUND REDUCTION - A Raman analyzer for analyzing light emitted from a Raman cell is provided that has a beam splitter configured to split the light emitted from the Raman cell into a first beam and a second beam. An atomic vapor filter can be used to filter a Raman scattered line from the first beam and a chopper system can periodically interrupt the first and second beams that are directed towards a photo detector, which can convert light from the first and second beams into an electrical signal. The signal output from the photo detector can optionally be amplified, digitized, Fourier filtered, and/or subjected to Fourier analysis.06-27-2013
20090046284SYSTEMS AND METHODS FOR FOOD SAFETY DETECTION - A method for detecting an ingredient in a food product includes establishing a spectral signature in a Raman spectrum obtained from a chemical substance; allowing a food sample solution obtained from a food product to come to contact with a first nano-scale surface structure in a first sensor, wherein the first sensor comprises a substrate, wherein the nano-scale surface structure comprises a plurality of columns over the substrate or a plurality of holes in the substrate; illuminating the food sample solution and the first nano-scale surface structure on the first sensor by a laser beam; scattering the laser beam by the food sample solution and the first nano-scale surface structure to produce a scattered light; obtaining a first Raman spectrum from the scattered light using a spectral analyzer; and identifying the spectral signature in the first Raman spectrum to determine the existence of the chemical substance in the food product.02-19-2009
20090046283METALIZED SEMICONDUCTOR SUBSTRATES FOR RAMAN SPECTROSCOPY - In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm.02-19-2009
20120113419NANOWIRE-BASED SYSTEMS FOR PERFORMING RAMAN SPECTROSCOPY - Embodiments of the present invention are directed to nanowire-based systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system comprises a substrate (05-10-2012
20120113418LIGHT AMPLIFYING DEVICES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY - A light amplifying device for surface enhanced Raman spectroscopy is disclosed herein. The device includes a dielectric layer having two opposed surfaces. A refractive index of the dielectric layer is higher than a refractive index of a material or environment directly adjacent thereto. At least one opening is formed in one of the two opposed surfaces of the dielectric layer, and at least one nano-antenna is established on the one of the two opposed surfaces of the dielectric layer. A gain region is positioned in the dielectric layer or adjacent to another of the two opposed surfaces of the dielectric layer.05-10-2012
20120236303FILTERED FIBER OPTIC PROBE - The invention provides improved multi-fiber, fiber optic probe assemblies in which the component parts are adapted for rapid assembly with precise alignment. Some embodiments are adapted to illuminate and collect light from a sample at a particular depth while minimizing interference arising from within the probe assembly itself. Also provided are methods for manufacturing the probe assemblies and optical apparatuses including the probe assemblies.09-20-2012
20120236302NANOSCALE VISOMETER DEVICE - A nano viscometer device suitable for determining the concentration of a solute within a fluid sample preferably includes a hollow core Photonic Crystal Fibre (HC-PCF) acting as a capillary tube having a core and means for filling the capillary tube with a fluid sample. Light is preferably guided light into the HC-PCF and detected exiting the tube. The rate at which the capillary tube is filled with the fluid is optically measured based on the light to determine the viscosity of the fluid to calculate the concentration of a solute. The preferred capillary viscometer is capable of measuring the viscosity of nano-litre quantities of a sample fluid. On one example, the preferred viscometer makes use of HC-PCF for the detection of glucose dissolved in nano water, demonstrating that HC-PCF can be used for continuous monitoring of glucose levels within blood plasma.09-20-2012
20120236301MEASUREMENT APPARATUS AND MEASUREMENT METHOD - A measurement apparatus for measuring the concentration of a target substance contained in a sample includes: a light source (light source device); a light-incident body (sensor chip) that has a sample contact surface, where an enhanced electric field is formed by metal particles, and enhances Raman scattering light radiated from the target substance by light emitted from the light source in the enhanced electric field; an irradiation unit that causes the light emitted from the light source to enter into a plurality of areas in the light-incident body; a light-receiving unit (light-receiving element) that receives the Raman scattering light radiated from a plurality of the areas; and a quantitative measurement unit (control device) that quantitatively measures a concentration of the target substance based on a total number of the areas and a strength of the Raman scattering light received from the areas.09-20-2012
20120236300METHOD FOR DETECTING BPA BY SURFACE ENHANCED RAMAN SPECTROSCOPY - A detection method of bisphenol A by the surface-enhanced Raman spectroscopy includes: soaking and extracting bisphenol A present in a sample with an organic solvent to form an extraction solution, adding methanol to the extraction solution to cause a polymer to precipitate from the extraction solution and leaving a filtrate behind, filtering and concentrating the filtrate, diluting the concentrated filtrate to volume with methanol, filtering the diluted filtrate through a filter with a pore size of 0.45 μm to obtain a pretreated sample; detecting bisphenol A present in the sample by Raman spectroscopy under an incident laser power of 100 to 300 mW, and a scan time of 2 to 20 seconds; mixing the pretreated sample with the colloidal gold in an appropriate ratio, followed by adjusting pH value, and then carrying out the detection of bisphenol A present in the sample by Raman spectroscopy.09-20-2012
20120236299HIGH-SPEED ON DEMAND DROPLET GENERATION AND SINGLE CELL ENCAPSULATION DRIVEN BY INDUCED CAVITATION - Methods and devices for the formation of droplets of a first fluid in a second fluid and the encapsulation of particles or cells within such droplets are disclosed. Impetus for droplet formation is provided by the creation of a transient bubble, which may be induced using a pulsed laser. Droplet volume and the frequency at which droplets are formed can be controlled by modulation of the pulsed laser. The disclosed methods and devices are particularly suitable for use in microfluidic devices.09-20-2012
20120236298TUNABLE APPARATUS FOR PERFORMING SERS - A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable substrate and a plurality of SERS-active nanoparticles disposed at a plurality of locations on the deformable substrate. The plurality of SERS-active nanoparticles are to enhance Raman scattered light emission from an analyte molecule located in close proximity to the SERS-active nanoparticles. In addition, the deformable substrate is to be deformed to vary distances between the SERS-active nanoparticles, in which varying distances between the SERS-active nanoparticles varies enhancement of an intensity of Raman scattered light emission from the analyte molecule.09-20-2012
20100020319PORTABLE LASER SYNTHESIZER FOR HIGH-SPEED MULTI-DIMENSIONAL SPECTROSCOPY - Portable, field-deployable laser synthesizer devices designed for multi-dimensional spectrometry and time-resolved and/or hyperspectral imaging include a coherent light source which simultaneously produces a very broad, energetic, discrete spectrum spanning through or within the ultraviolet, visible, and near infrared wavelengths. The light output is spectrally resolved and each wavelength is delayed with respect to each other. A probe enables light delivery to a target. For multidimensional spectroscopy applications, the probe can collect the resulting emission and deliver this radiation to a time gated spectrometer for temporal and spectral analysis.01-28-2010
20120154801Spectrometer - A spectroscopic system is provided. In one embodiment, the spectroscopic system comprises a light source adapted to provide a beam of illumination; an optical system adapted to provide the beam of illumination to a sample and receive a spectroscopy signal from the sample and direct the spectroscopy signal to at least one single channel detector, wherein the optical system comprises an adjustable dispersing element for directing one or more spectral features of the spectroscopy signal to the at least one single channel detector; a calibration detector adapted to determine a set point of the adjustable dispersing element; and a source synchronization component adapted to synchronize an operation of the light source and the at least one single channel detector. A method of calibrating a dispersing element of a spectrometer is also provided. In one embodiment, the method comprises determining a set point along a path of an adjustable dispersing element, wherein the set point corresponds to a position of the dispersing element where a calibration signal of a spectrometer is detected at a calibration sensor of the spectrometer; adjusting the position of the dispersing element along the path by a predetermined offset measurement from the set point; and directing at least a portion of a spectroscopic signal from the dispersing element to a spectroscopic signal detector of the spectrometer.06-21-2012
20100265499PROGRAMMABLE RAMAN TRANSDUCER - A programmable Raman transducer is disclosed for detecting the presence or absence of a preselected compound in a sample. The transducer, in a preferred embodiment, includes a laser source for generating laser light for illuminating the sample. Collector optics, absent a spatial filter, are used for collecting Raman-scattered light from the sample. A detector generates spectral data from the Raman-scattered light, and a digital processor compares the spectral data to a database of spectral data on selected compounds, including the preselected compound to generate a binary signal indicating presence or absence of the preselected compound.10-21-2010
20100171951METHODS AND APPARATUS FOR REMOTE RAMAN AND LASER-INDUCED BREAKDOWN SPECTROMETRY - An spectrometer including Raman and LIBS spectroscopy capabilities is disclosed. The spectrometer includes a laser source configurable to produce a lased light directable towards a target substance, the laser source having a single wavelength and having sufficient power to cause a portion of the target to emit Raman scattering and sufficient to ablate a portion of the target substance to produce a plasma plume. A separate remote light collector is optically configurable to collect light emitted from the portion of the target emitting Raman scattering and from the portion of the target producing the plasma plume. A filter is optically coupled to the remote light collector to remove reflected light and Rayleigh-scattered light, and a spectroscope is optically coupled to the filter and configured to separate the collected and filtered light into a frequency spectrum comprising a Raman spectrum and a laser-induced breakdown spectrum. Finally, an electronic light sensor is used to record the frequency spectrum.07-08-2010
20100171948METALIZED SEMICONDUCTOR SUBSTRATES FOR RAMAN SPECTROSCOPY - In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm.07-08-2010
20090015829SPECTROGRAPH CALIBRATION USING KNOWN LIGHT SOURCE AND RAMAN SCATTERING - A method is provided for calibrating a spectrometer device used for Raman scattering analysis. A predetermined dispersion curve for a diffraction grating or spectrograph of the spectrometer device is modified based on spectrum data associated with detected dispersed light from a calibration light source to produce a modified dispersion curve. The wavelength of a Raman light source on a light detection device is determined. Calibration data for the spectrometer device is computed from the Raman line peak positions for the first chemical, the wavelength on the detection device of the Raman light source and the modified dispersion curve.01-15-2009
20090310131Spectroscopy system - A Raman spectroscopy system has a filter arrangement comprising two filters (12-17-2009
20090310132Spectroscopic apparatus and methods - In a Raman spectroscopy apparatus, exciting light is focussed on a sample (12-17-2009
20080266555Surface Enhanced Raman Spectroscopy Using Shaped Gold Nanoparticles - Surface enhanced Raman scattering (SERS) spectra of 4-mercaptobenzoic acid (4-MBA) self-assembled monolayers (SAMs) on gold substrates is presented for SAMs onto which gold nanoparticles of various shapes have been electrostatically immobilized. SERS spectra of 4-MBA SAMs are enhanced in the presence of immobilized gold nanocrystals by a factor of 1010-30-2008
20100085567LASER SPECTROSCOPY SYSTEM - A spectroscopy system including first and second lasers. The first laser is triggered to induce a plasma, such as on a surface of a target at a stand-off distance from the target. The second laser stimulates amplified emissions from the plasma detected by one or more spectroscopes. The gain induced by the second laser detects traces of explosives and other substances on surfaces at stand-off distances. The spectroscopy systems use the same telescopic optics to collect emissions from the detection surface and activated at or just before the peak emission intensity useful for detecting element signatures and intensity ratios from the trace elements in the plasma.04-08-2010
20100201977OPTICAL MULTIPASS CELL FOR REPEATED PASSING OF LIGHT THROUGH THE SAME POINT - An optical reimaging element comprising: a first off-axis parabolic mirror having only the portion of the mirror surface below the first plane that passes through its focal point and is perpendicular to the axis of the first parabola associated with the first mirror, the portion of the first mirror being on the same side of the first plane as the vertex of the first parabola; a second off axis parabolic mirror identical to the first mirror also having only the portion of the mirror surface below the second plane that passes through its focal point and is perpendicular to the axis of the second parabola associated with the second mirror, the portion of the second mirror being on the same side of the second plane as the vertex of the second parabola; and the first and second mirrors being in optical communication with each other so that their first and second planes coincide and so that their parabolic mirror surfaces are symmetrically opposing, confocal, and coaxial thereby having the property that a ray of light coming from the common focal point of the parabolic mirrors and incident onto one of the parabolic mirrors reflects to the other parabolic mirror wherein it reflects back to the focal point, but at an angle with the direction in which it left the focal point. An optical reimaging element comprising: a material, the material comprising: a top face; a bottom face; a first side face; a second side face; a third side face; and where the first and second of the side faces are in the shape of two symmetrically opposing, confocal, and coaxial parabolic surfaces so that the common axis of the parabolic surfaces is parallel and midway between the top and bottom faces and the third side face is spherical with the center of curvature coincident with the common focal point of the parabolic surfaces so that any ray of light originating from the common focal point and directed to the element is incident normal to the third face, transmits into the element without changing direction, is incident on one of the parabolic surfaces, reflects by total internal reflection to the other of the two parabolic surfaces, is reflected again by total internal reflection to come at normal incidence to the third face, transmits out of the element without changing direction and returns to the common focal point at an angle to the direction in which it left the focal point.08-12-2010
20090225310SURFACE-ENHANCED RAMAN SPECTROSCOPY SUBSTRATE FOR ARSENIC SENSING IN GROUNDWATER - A surface-enhanced Raman spectroscopy (SERS) substrate formed from a plurality of monolayers of polyhedral silver nanocrystals, wherein at least one of the monolayers has polyvinypyrrolidone (PVP) on its surface, and thereby configured for sensing arsenic is described. Highly active SERS substrates are formed by assembling high density monolayers of differently shaped silver nanocrystals onto a solid support. SERS detection is performed directly on this substrate by placing a droplet of the analyte solution onto the nanocrystal monolayer. Adsorbed polymer, polyvinypyrrolidone (PVP), on the surface of the nanoparticles facilitates the binding of both arsenate and arsenite near the silver surface, allowing for highly accurate and sensitive detection capabilities.09-10-2009
20120099102DUAL AND MULTI-WAVELENGTH SAMPLING PROBE FOR RAMAN SPECTROSCOPY - In certain embodiments, the invention relates to optical probes and methods for conducting Raman spectroscopy of a material at multiple excitation wavelengths. The probes and methods utilize optical elements to focus outputs from a plurality of light sources or lasers onto a sample, collect backscattered light from the sample, separate Raman spectra from the backscattered light, and provide at least one output containing the spectra. By utilizing multiple excitation wavelengths, the probes and methods avoid Raman measurement issues that may occur due to, for example, fluorescence and/or luminescence.04-26-2012
20110285992METHODS OF FABRICATING SURFACE ENHANCED RAMAN SCATTERING SUBSTRATES - A method of fabricating a surface enhanced Raman scattering (SERS) substrate. In one embodiment, the method has the steps of simultaneously evaporating a metal at a first evaporation rate and a polymer at a second evaporation rate different from the first evaporation rate, to form a nanocomposite of the metal and the polymer, depositing the nanocomposite onto a substrate, and applying an etching process to the deposited nanocomposite on the substrate to remove the polymer material, thereby forming an SERS substrate.11-24-2011
20110285991CHEMICAL/BIOLOGICAL SENSOR EMPLOYING SCATTERED CHROMATIC COMPONENTS IN NANO-PATTERNED APERIODIC SURFACES - A label-free multiplexed sensing platform is based on light interaction with aperiodic photonic structures with an advantage of a broadband operation. Multiple-scattering-induced “fingerprinting” colorimetric signatures can be used as a transduction mechanism. Aperiodic sensing platforms can operate in the infrared to provide an overlap with spectral fingerprints of biological molecules. Miniaturized optical biosensors may be based on engineered colorimetric scattering signatures (structural color), sharp spectral features, non-uniform angular distributions of scattered light, and broadband manipulation of the local density of states in nano-textured scattering surfaces with deterministic aperiodic order. The biosensors can be fabricated in semiconductor, metal, low- and high-index dielectric platforms using standard nanofabrication techniques such as electron-beam lithography, ion-beam milling, etc, and can be replicated over large areas by standard nano-imprint lithography.11-24-2011
20110299071MULTIPOINT METHOD FOR IDENTIFYING HAZARDOUS AGENTS - The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.12-08-2011
20110292384SYSTEM AND METHOD FOR DETECTION OF FLEXIBLE PIPE ARMOR WIRE RUPTURES - A system and method for detecting breakage, rupture or malfunctioning of a pipe or cable structure, including sensing elements for monitoring the structure and placed in, on or around the structure for monitoring the breakage, rupture or malfunctioning of the structure. The sensing elements provide sensing data regarding events related to breakage, rupture or malfunctioning and are placed near the structure so as to perform a breakage, rupture or malfunction detection function, and within a distance sufficient to obtain a measureable strain, tension, torsion, vibration, acceleration, and/or temperature response signal based on the breakage, rupture or malfunctioning of the structure. One of the sensing elements is based on Coherent Rayleigh Noise (CRN) sensing techniques, and the system is configured to interpret the sensed data for determining the breakage, rupture or malfunctioning of the structure.12-01-2011
20090273780RAMAN SPECTRUM DETECTING METHOD AND RAMAN SPECTRUM DETECTING DEVICE - A Raman spectrum detecting method includes a liquid sample contacting step of placing a liquid sample containing a reference substance and a specimen in contact with a detection surface, the reference substance generating a known Raman spectrum having at least one peak therein that is different from peaks in a Raman spectrum generated by the specimen; a scattered light detecting step of irradiating the detection surface in contact with the liquid sample with an excitation light and detecting Raman scattered light occurring from the liquid sample; and a normalizing step of extracting a Raman spectrum signal of the reference substance and a Raman spectrum signal of the specimen from the signal detected in the scattered light detecting step and normalizing a signal intensity of the Raman spectrum signal of the specimen according to an intensity of the Raman spectrum signal of the reference substance.11-05-2009
20090251693Analysis for Glucose Products Using Pyridinylboronic Acid - A method of analyzing a target analyte using laser excitation spectroscopy, mass spectroscopy, or colormetric analysis, where the analysis is enhanced by using pyridinylboronic acid.10-08-2009
20090002700SOLUTION SAMPLE PLATE WITH WELLS DESIGNED FOR IMPROVED RAMAN SCATTERING SIGNAL DETECTION EFFICIENCY - Devices, methods of using the device, systems including the device that include a sample plate with sample containers (wells), wherein at least a portion of the surface of the sample plate and/or sample containers is coated with an optical reflective material. The optical reflective material, provides enhanced excitation signal intensity and enhanced Raman signal intensity. Such enhancement provides improved total signal detection capabilities, and methods of improved focusing algorithms.01-01-2009
20100284000METHOD AND APPARATUS FOR DISTRIBUTED SENSING UTILIZING OPTICAL SCATTERING IN OPTICAL WAVEGUIDES - The present invention relates to a method and apparatus for distributed sensing utilizing optical scattering in optical waveguides and reveals two types of the invention. One type of the invention is to characterize optical scattering while actively controlling the temperature of the optical waveguide. The other type of the invention is to characterize optical scattering while strain/stress is induced into the optical waveguide through interaction of the jackets or coatings of the optical waveguide with objects under test. In one embodiment of the invention, the optical scattering based method and apparatus can sense liquid level, liquid distribution, and temperature gradient on ground and in low gravity. Other embodiments of the invention can detect location and concentration of liquid spill and gas leak along pipelines, or measure liquid or gas flow rates. Moreover, the method and apparatus described in the invention have capabilities of sensing multiple physical and chemical parameters using one sensing optical waveguide.11-11-2010
20100265500STRUCTURE FOR SURFACE ENHANCED RAMAN SPECTROSCOPY - A structure for surface enhanced Raman spectroscopy is disclosed herein. The structure is made up of a substrate, a self-assembled layer of first metal particles established on the substrate, and a self-assembled layer of second metal particles established such that the second metal particles are positioned at interstitial spaces between the first metal particles. The first metal particles have a first predetermined diameter, and the second metal particles have a second predetermined diameter that is smaller than the first predetermined diameter.10-21-2010
20110267608TUNABLE APPARATUS FOR PERFORMING SERS - A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable layer and a plurality of SERS-active nanoparticles disposed at one or more locations on the deformable layer, wherein the one or more locations are configured to be illuminated with light of a pump wavelength to cause Raman excitation light to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles. In addition, a morphology of the deformable layer is configured to be controllably varied to modify an intensity of the Raman scattered light produced from the molecules.11-03-2011
20100033717Raman Chemical Imaging of Implantable Drug Delivery Devices - A system and method of determining an attribute of a biological tissue sample or a drug delivery device. A sample is illuminated with substantially monochromatic light to thereby generate Raman scattered photons. The Raman scattered photons are assessed to thereby generate a spectroscopic data set wherein said spectroscopic data set comprises at least one of: a Raman spectra and a spatially accurate wavelength resolved image. Tile spectroscopic data set is evaluated to determine at least one of: an attribute of a biological tissue sample and a drug delivery device. In one embodiment, the biological tissue comprises arterial tissue. In another embodiment, the drug delivery device is a drug-eluting stent. In another embodiment, Raman chemical imaging can be used to evaluate a sample and identify at least one of: the tissue, a drug, a drug delivery device, and a matrix associated with a drug delivery device.02-11-2010
20100033718BIOCHIP READER AND ELECTROPHORESIS SYSTEM - A biochip reader wherein spectroscopic information of a sample under analysis is arranged in spaces between images of the sample arranged on a biochip. The reader comprises a confocal microscope and the biochip comprises a transparent substrate to allow passage of the excitation light and fluorescent light from the sample with the excitation light being applied from the side opposite that on which the samples are arranged so that noise from dust and the like is avoided by the transmitted light avoiding contact with the dust. Another aspect is an electrophoresis system wherein different coloring material are used for each of a variety of target substances, so that the same lane and area are utilizable to concurrently detect a polychrome fluorescent pattern of the different targets. A confocal scanner or fluorescence imaging system is used with a plurality of filters to detect the multi-colored fluorescences of the target substance. Advantageously, in the biochip reader, a lower S/N ration is obtained together with lower cost; and in the electrophoresis system, concurrent detection of multiple polychromatic fluorescence patters is attained.02-11-2010
20100007876HOLLOW-CORE WAVEGUIDE-BASED RAMAN SYSTEMS AND METHODS - Embodiments of the invention include a method for sensing. Other embodiments include a method for sensing molecules, for example, homonuclear diatomic molecules. The method may include transmitting light from a light source through a hollow-core wave-guiding device that exhibits a low attenuation at predetermined operating optical frequencies; introducing a gaseous medium between the light source and the hollow-core wave-guiding device; and detecting molecules within the gas.01-14-2010
20110007309Method for Analysis of Pathogenic Microorganisms Using Raman Spectroscopic Techniques - A method for assessing the presence of a pathogenic microorganism in a sample. A sample is illuminated to thereby produce a first plurality of interacted photons which may be scattered, emitted, reflected and/or absorbed by the sample. The first plurality of interacted photons are assessed to thereby generate a Raman data set representative of the sample. This Raman data set is analyzed to thereby determine at least one of: the presence of a pathogenic microorganism in said sample and the absence of a pathogenic microorganism in said sample. The Raman data set may comprise at least one of a Raman spectrum and/or a Raman chemical image representative of the sample. The analysis may comprise comparing said Raman data set to at least one reference Raman data set representative of a known sample. This may be achieved using a chemometric technique.01-13-2011
20090141271Security Screening Using Raman Analysis - Method and apparatus for screening objects using Raman scattering methods to detect the presence of predefined substances or classes of substances. The predefined substances may be hazardous, toxic, or explosive. Radiation is supplied to an incident region of an object. Scattered light is collected from a collection region on the surface of the object spaced from the incident region. The characteristics of the scattered light include Raman features related to the predefined substances. The Raman features allow the presence, or not, of the predefined substances to be determined.06-04-2009
20100085565Method, Structure, and apparatus for Raman spectroscopy - Disclosed herein are a Raman spectroscopy structure comprising a porous material substrate, and a method of performing Raman spectroscopy of a sample disposed adjacent to the structure comprising the porous material substrate. Generally, the substrate includes one or more layers of a porous material such as porous silicon, porous polysilicon, porous ceramics, porous silica, porous alumina, porous silicon-germanium, porous germanium, porous gallium arsenide, porous gallium phosphide, porous zinc oxide, and porous silicon carbide. It has been discovered that such a substrate material, when excited with near-infrared light, does not exhibit undesired background fluorescence characteristic of other known Raman spectroscopy substrates.04-08-2010
20090213370APPARATUS AND METHOD FOR OBTAINING IMAGES USING COHERENT ANTI-STOKES RAMAN SCATTERING - Disclosed is an apparatus and method for obtaining images using coherent anti-stokes Raman scattering. The apparatus for obtaining images using coherent anti-stokes Raman scattering according to the present invention comprises: a pump light source and a stokes light source that irradiate pump light and stokes light on a sample to generate anti-stokes light having anti-stokes frequency; a reference light source that generates reference light; and an image obtaining unit that obtains the images of the sample using a change in phase of the reference light due to a change in the refractive index of the sample in the vicinity of the anti-stokes frequency. Thereby, the present invention can provide the apparatus for obtaining images using coherent anti-stokes Raman scattering that is not affected by a non-resonant background signal phenomenon, strong resistance against noise even in a weak signal, and has excellent sensitivity and resolution.08-27-2009
20100091274Plasmonic electric-field concentrator arrays and systems for performing raman spectroscopy - Various embodiments of the present invention relate to plasmonic electric-field concentrators and to systems incorporating the plasmonic electric-field concentrators to perform Raman spectroscopy. In one aspect, a plasmonic electric-field concentrator comprises two or more large features, and a relatively small feature similar in shape to large features positioned adjacent to the two or more large features. The features are arranged so that when light of an appropriate wavelength is incident on the features, surface plasmon polaritons form on the outer surfaces of the features. The surface plasmon polaritons have associated electric fields extending perpendicular to the surfaces of the features. The electric fields are concentrated in the space between features forming an electric field hot spot that enhances Raman scattered light emitted from an analyte proximate to or absorbed on the features.04-15-2010
20100085564SYSTEMS AND METHODS FOR DETECTING CHEMICAL AND BIOLOGICAL SUBSTANCES - A method for detecting an ingredient in a food product or detecting a disease includes allowing a food sample solution obtained from a food product or a body fluid from an individual to come to contact with a nano-scale surface structure in a sensor, wherein the nano-scale surface structure comprises a plurality of columns over a substrate or a plurality of holes in a substrate. The method includes illuminating the food sample solution or the body fluid on the nano-scale surface structure on the sensor by a laser beam; obtaining a Raman spectrum from the scattered light using a spectral analyzer; and identifying the spectral signature in the Raman spectrum to determine the existence of the chemical substance in the food product or identifying a disease in the individual.04-08-2010
20130021605APPARATUS HAVING NANO-FINGERS OF DIFFFERENT PHSYICAL CHARACTERISTICS - An apparatus includes a substrate and a plurality of nano-fingers attached at respective first ends to the substrate and freely movable along their lengths, in which a first set of the plurality of nano-fingers comprises a first physical characteristic, wherein a second set of the plurality of nano-fingers comprises a second physical characteristic, and wherein the first physical characteristic differs from the second physical characteristic.01-24-2013
20100079754SYSTEMS FOR PERFORMING RAMAN SPECTROSCOPY - Various embodiments of the present invention relate generally to systems for performing Raman spectroscopy. In one embodiment, a system for performing Raman spectroscopy comprises an analyte holder having a surface configured to retain an analyte and a light concentrator configured to receive an incident beam of light, split the incident beam into one or more beams, and direct the one or more beams to substantially intersect at the surface. The system may also include a collector configured to focus each of the one or more beams onto the surface, collect the Raman scattered light emitted from the analyte, and direct the Raman scattered light away from the surface.04-01-2010
20120287429Waveguide-Integrated Plasmonic Resonator for Integrated SERS Measurements - A resonator structure is disclosed. In some embodiments, the resonator structure may include a metal-insulator-metal waveguide comprising a first metal layer, a second metal layer, and an insulating layer between the first metal layer and the second metal layer, wherein the insulating layer comprises a resonating cavity. The resonator structure may further include a mirror formed in the resonating cavity, wherein the mirror comprises at least one nanoscale metallic reflector positioned at least partly in the insulating layer.11-15-2012
20100091275METAL-POLYMER COMPOSITES COMPRISING NANOSTRUCTURES AND APPLICATIONS THEREOF - Metal-polymer composites, and methods of making and use thereof, said composites comprising a thermally-cured dense polyaniline substrate; an acid dopant; and, metal nanostructure deposits wherein the deposits have a morphology dependent upon the acid dopant.04-15-2010
20110170095DSC-RAMEN ANALYTICAL SYSTEM AND METHOD - A combination DSC testing and Raman spectroscopy system is provided for running investigations on a single sample in the same experiment. A DSC instrument includes a set of optics, which allows an associated Raman unit to emit a pulsed laser that intermittently directs a laser signal to the sample and to collect the Raman signal while simultaneously running a DSC experiment on the same sample. The DSC has a vessel adapted to contain the sample, a thermal analysis environment is adapted to hold the vessel. An associated temperature control apparatus changes the temperature of the analysis environment between temperature endpoints to observe the sample at various transitions. The Raman spectroscopy unit is configured to generate laser pulses which stimulate emission of Raman spectra to provide further information about the sample without introducing excessive noise in the DSC aspect of the investigation.07-14-2011
20090201496SURFACE-ENHANCED RAMAN SCATTERING BASED ON NANOMATERIALS AS SUBSTRATE - The present invention relates to an arrangement of nanomaterials which act as a substrate for a surface-enhanced Raman scattering. A method of Raman scattering and a method of manufacturing the substrate are also disclosed. The substrate comprises a plurality of nanostructures, for example nanowires, and metal nanoparticles are arranged on the surface of the nanostructures. The metal nanoparticles are of a material selected from the group comprising Au, Ag, Cu, Fe, Co, Ni, Ru, Rh, Pd, Pt or an alloy. This nano-on-nano arrangement increase the surface area and provides a significant increase in detection sensitivity. A substrate comprising a nanomaterial substrate form of a plurality of nanostructure of a noble metal and noble metal nanoparticles of a different material on the surface of said nanostructure is also disclosed.08-13-2009
20090147254INTEGRATED QUARTZ BIOLOGICAL SENSOR AND METHOD - A sensor integrates a quartz nanoresonator for mass detection and SERS for optical detection in a same cavity on a chip for redundancy in the detection of a species.06-11-2009
20090273778SURFACE ENHANCED RESONANT RAMAN SPECTROSCOPY - A method of performing surface-enhanced resonant Raman spectroscopy (SERRS) in respect of a sample (11-05-2009
20090273779Metal nano-void photonic crystal for enhanced raman spectroscopy - A planar optical platform for generating a Raman signal from a foreign object comprises an input region and an output region, for receiving and extracting optical radiation, optically coupled to a plasmonic band structure region. The plasmonic band structure region comprises a layer of a first material, having a first refractive index, patterned with an array of sub-regions of a second material, having a second refractive index, wherein a side-wall of each sub-region is coated with a metallodielectric layer. The array of sub-regions gives rise to a plasmonic band structure and, in use, each sub-region confines a plasmon resonance excited by optical radiation coupled into the plasmonic band structure region, which gives rise to a Raman signal from a foreign object placed proximate the plasmonic band structure region. The platform may be incorporated into a spectroscopic measurement system and is particularly useful for surface-enhanced Raman spectroscopy of analyte molecules.11-05-2009
20090290150LASER MICROSCOPE APPARATUS - To enable both observations of coherent anti-Stokes Raman scattering light and multiphoton fluorescence in a same apparatus so as to observe a specimen by various observation methods. There is provided a laser microscope apparatus comprising: two optical paths for guiding pulsed laser beams having two different frequencies whose frequency difference is approximately equal to a specific molecular vibration frequency in a specimen; a multiplexer for combining the pulsed laser beams guided through these two optical paths; and a frequency dispersion adjuster which is provided on at least one of these two optical paths, and is capable of adjustment to approximately equalize frequency dispersion quantities of the pulsed laser beams guided through the two optical paths.11-26-2009
20090103082SYSTEMS AND METHODS FOR BIOLOGICAL AND CHEMICAL DETECTION - A biological and chemical detection system is provided that detects and identifies biological and/or chemical particulates of interest. The biological and chemical detection system comprises a collector, a first optical device, a second optical device and a processor. The collector is configured to deposit particulates drawn from a fluid stream onto a sample substrate to define a sample area. The first optical device derives first data relative to at least a portion of the sample area, which is analyzed to determine at least one field of view and/or specific target location. The second optical device then interrogates the sample area at each determined target location, e.g., using Raman spectroscopy, to produce interrogation data. The processor determines whether the sample area includes predetermined biological or chemical particulates of interest based upon an analysis of the interrogation data and triggers an event such as an alarm or message if the predetermined biological or chemical particulates of interest are identified.04-23-2009
20100060894NANOSTRUCTURED METAL-POLYANILINE COMPOSITES AND APPLICATIONS THEREOF - Metal-polyaniline (PANI) composites are provided together with a process of preparing such composites by an electrodeless process. The metal of the composite can have nanoscale structural features and the composites can be used in applications such as catalysis for hydrogenation reactions and for analytical detection methods employing SERS.03-11-2010
20100060893ASSAY PARTICLE CONCENTRATION AND IMAGING APPARATUS AND METHOD - An assay apparatus having a sample vessel within which an assay may be performed. The apparatus further includes a holder having a receptacle, socket or other device configured to operatively receive the sample vessel in a precise and easily repeated location with respect to the holder. A magnet may be operatively associated with the holder such that a magnetic field generated by the magnet intersects a portion of the sample vessel defining a magnetic concentration region within the sample vessel. A separate or integrated detection or interrogation instrument, typically a spectrometer, may be provided.03-11-2010
20100141940Sensor for Identifying at Least One Particle by Means of Raman-Spectroscopy - A sensor for identifying at least one particle by means of Raman-spectroscopy, comprising an optical trapping system for the at least one particle, including a laser-beam source, acting further as a Raman excitation source for the at least one particle, and a Raman-spectrometer for measuring the spectrally modified light scattered by the at least one particle and for identifying same, wherein the optical trapping system comprises a photonic crystal directly linked with the laser-beam source, which photonic crystal has multiple cavities at predetermined positions, and wherein the laser-beam source in use resonantly excites one or more predetermined electromagnetic modes of the cavities at said positions for trapping and Raman-exciting the at least one particle.06-10-2010
20080239306SYSTEM AND METHOD FOR OPTICAL POWER MANAGEMENT - A system and method for managing optical power for controlling thermal alteration of a sample undergoing spectroscopic analysis is provided. The system includes a moveable laser beam generator for irradiating the sample and a beam shaping device for moving and shaping the laser beam to prevent thermal overload or build up in the sample. The moveable laser beam generator includes at least one beam shaping device selected from the group consisting of at least one optical lens, at least one optical diffractor, at least one optical path difference modulator, at least one moveable mirror, at least one Micro-Electro-Mechanical Systems (MEMS) integrated circuit (IC), and/or a liquid droplet. The system also includes an at least two degree of freedom (2 DOF) moveable substrate platform and a controller for controlling the laser beam generator and the substrate platform, and for analyzing light reflected from the sample.10-02-2008
20080239307Sequencing single molecules using surface-enhanced Raman scattering - A surface-enhanced Raman scattering method and apparatus to sequence polymeric biomolecules such as DNA, RNA, or proteins is introduced. The method uses metallic nanostructures such as, for example, spherical or cylindrical Au or Ag nanoparticles having characteristic lengths of 10-100 nm which when illuminated with light of the appropriate wavelength produce resonant oscillations of the conduction electrons (plasmon resonance). Electric field enhancements of 30-1000 near the particle surface resulting from such oscillations increase Raman scattering cross-sections by about 1010-02-2008
20090168058SYSTEM AND METHOD FOR IMPROVED BIODETECTION - Portable substance identification system and method are configured to identify at least one detection target faster and with greater accuracy than is possible using prior substance identification systems and/or prior substance identification techniques. An embodiment of the portable substance identification system includes a portable substance identification device containing a Raman spectrometer, and a collection stem that includes a collector. One or more reservoirs for a liquid medium and/or at least one reagent can be formed in the collection stem. The cartridge can include a chamber in which the reagents, liquid medium, and at least one detection target picked up by the collector are mixed. A magnet, positioned at a slant angle, can be used to form at least one pellet of aggregated magnetic particles within a pellet forming area of the chamber. The pellet is formed to maximize its surface area.07-02-2009
20080273199Spectroscopic system and method for predicting outcome of disease - A system and method to predict the progression of disease of a test sample. A group of known biological samples is provided. Each known biological sample has an associated known outcome including a non-diseased sample or a diseased sample. A Raman data set is obtained for each known biological sample. Each Raman data set is analyzed to identify a diseased or non-diseased reference Raman data set depending on whether respective biological sample is the non-diseased sample or the diseased sample. A first database is generated where the first database contains reference Raman data sets for all diseased samples. A second database is generated where the second database contains reference Raman data sets for all non-diseased samples. A test Raman data set of a test biological sample is received, where the test biological sample has an unknown disease status. A diagnostic is provided as to whether the test sample is a non-diseased sample or a diseased sample. The diagnostic is obtained by comparing the test Raman data set against the reference Raman data sets in the first and the second databases using a chemometric technique. A prediction of the progression of disease may be then provided.11-06-2008
20080278719WAVELENGTH DEPENDENT REFLECTIVE SAMPLE SUBSTRATES FOR RAMAN AND FLUORESCENCE SPECTROSCOPY - A material which is generally transparent in the visible region of the spectrum but reflective at laser wavelengths reduces undesirable, substrate-induced Raman and fluorescence scattering. A substrate provides a surface for supporting the sample, with the material being disposed between the surface of the substrate and the sample. The material is substantially transparent in the visible region of the spectrum but reflective at the laser wavelength, thereby minimizing unwanted Raman or fluorescence scattering that would be produced by the substrate if the material were not present. The substrate will typically be a glass microscope slide or multi-cell well plate. The optical filter material is preferably a multilayer dielectric filter acting as a “hot mirror” that reflects near-infrared energy. An advantage of visible transmission is that it allows back illumination from behind/underneath the slide or well plate, thereby being visible to a microscope's eyepiece or video camera. Methods and article are also disclosed.11-13-2008
20080291442Chemical and biological sensing using metallic particles in amplifying and absorbing media - A film for surface enhanced raman scattering may be utilized for chemical and biological sensing. The film includes a polymeric layer, and a metallic nanoparticle having a cross-section, the metallic nanoparticle being embedded in the polymeric layer. The polymeric layer has a thickness less than a largest straight line through the cross-section of said metallic nanoparticle. The polymeric layer is selected from a group of absorbing media and amplifying media, and the metallic nanoparticle may be gold. The metallic nanoparticle may also be a shape selected from a group of spheroids and rods.11-27-2008
20080304061Polarimetric Raman System and Method For Analysing a Sample - A Raman method and system for analysing a sample including an excitation source emitting an incident light beam, a sample holder for mounting the sample, elements for focusing the incident light beam onto the sample surface to generate a Raman scattered light having an intensity, elements for collecting the Raman scattered light to form a Raman scattered light beam, a detection system measuring intensity of the Raman scattered light beam as a function of time. The system includes at least a polarization state generator able to generate four independent polarization states or a polarization state analyzer able to analyze four independent polarization states to detect the intensity of the Raman scattered light beam and calculate a partial or complete Mueller-Stokes matrix of the sample.12-11-2008
20080309931Coherently Controlled Nonlinear Raman Spectroscopy - A method and system (12-18-2008
20120287428NONLINEAR RAMAN SPECTROSCOPIC APPARATUS, MICROSPECTROSCOPIC APPARATUS, AND MICROSPECTROSCOPIC IMAGING APPARATUS - Provided is a nonlinear Raman spectroscopic apparatus includes two light sources and a pulse control section. The two light sources are each configured to emit short-pulse laser light. The pulse control section is configured to time-delay the short-pulse laser light emitted from one of the light sources.11-15-2012
20100265498METHOD AND APPARATUS FOR MICROLENS ARRAY/FIBER OPTIC IMAGING - A novel approach for chemical imaging is disclosed. In one embodiment, the disclosure relates to a system for producing a spatially accurate wavelength-resolved image of a sample from photons scattered from the sample, comprising an optical lens; a first optical fiber bundle of M fibers; a second optical fiber bundle of N fibers; an optical fiber switch; and a charge coupled device, wherein the image comprises plural sub-images, and wherein each sub-image is formed from photons scattered from a predetermined two spatial dimension portion of the sample, and wherein the scattered photons forming each sub-image have a predetermined wavelength different from a predetermined wavelength of scattered photons forming the other sub-images, and wherein the scattered photons for each sub-image are collected substantially simultaneously.10-21-2010
20090002699METHOD AND DEVICE FOR IDENTIFYING AN UNKNOWN SUBSTANCE - A device for identifying an unknown substance includes an optical source configured to direct a laser excitation beam at the unknown substance. A detector is configured to detect scattered light from the unknown substance and generate at least one signal representative of a scattering spectrum corresponding to at least one chemical within the unknown substance. A microprocessor is in signal communication with the detector and configured to generate a pattern representative of the at least one chemical in response to the at least one signal received from the detector to identify the chemical composition of the unknown substance. The device is configured to complete a bioassay to identify a biological nature of the unknown substance.01-01-2009
20080266556Nanowire configured to couple electromagnetic radiation to selected guided wave, devices using same, and methods of fabricating same - Various aspects of the present invention are directed to a nanowire configured to couple electromagnetic radiation to a selected guided wave and devices incorporating such nanowires. In one aspect of the present invention, a nanowire structure includes a substrate and at least one nanowire attached to the substrate. A diameter, composition, or both may vary generally periodically along a length of the at least one nanowire. A coating may cover at least part of a circumferential surface of the at least one nanowire. The nanowire structure may be incorporated in a device including at least one optical-to-electrical converter operable to convert a guided wave propagating along the length of the at least one nanowire, at least in part responsive to irradiation, to an electrical signal. Other aspects of the present invention are directed to methods of fabricating nanowires structured to support guided waves.10-30-2008
20120092661Applications of laser-processed substrate for molecular diagnostics - Surface enhanced Raman Scattering (SERS) and related modalities offer greatly enhanced sensitivity and selectivity for detection of molecular species through the excitation of plasmon modes and their coupling to molecular vibrational modes. One of the chief obstacles to widespread application is the availability of suitable nanostructured materials that exhibit strong enhancement of Raman scattering, are inexpensive to fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other photonic sensing that use semiconductor and metal surfaces fabricated using femtosecond laser processing. A noble metal film (e.g., silver or gold) is evaporated onto the resulting nanostructured surfaces for use as a substrate for SERS. These surfaces are inexpensive to produce and can have their statistical properties precisely tailored by varying the laser processing. Surfaces can be readily micropatterned and both stochastic and self-organized structures can be fabricated. This material has application to a variety of genomic, proteomic, and biosensing applications including label free applications including binding detection. Using this material, monolithic or arrayed substrates can be designed. Substrates for cell culture and microlabs incorporating microfluidics and electrochemical processing can be fabricated as well. Laser processing can be used to form channels in the substrate or a material sandwiched onto it in order to introduce reagents and drive chemical reactions. The substrate can be fabricated so application of an electric potential enables separation of materials by electrophoresis or electro-osmosis.04-19-2012
20100271630HIGHLY COMPACT DESIGN FOR RAMAN SPECTROMETRY - There is provided a Raman signal detection including a laser emitter and an optical element. The optical element includes an optical element body, an emitter face with a short pass optical coating, a Raman signal face with a long pass optical coating and a sample face. The optical element is positioned with a laser emitter output beam incident upon the emitter face. The emitter face receives the laser emitter output beam and transmits an emitter face output beam through the optical element body and the sample face to emit a sample face output beam. The sample face receives and transmits a sample reflection beam generated from the sample face output beam to the emitter face. The emitter face reflects and transmits the sample reflection beam the sample reflection beam through the Raman signal face to emit a Raman signal output beam to a Raman signal detector.10-28-2010
20100271629Method and system for combined raman and libs detection - In one embodiment, the disclosure relates to a method for interrogating a sample by: illuminating a first region of the sample with a first illumination pattern to obtain a plurality of first sample photons; illuminating a second region of the sample with a second illumination pattern to obtain a plurality of second sample photons; processing the plurality of first sample photons to obtain a characteristic atomic emission of the first region and processing the plurality of second sample photons to obtain a Raman spectrum; and identifying the sample through at least one of the characteristic atomic emission of the first region or the Raman spectrum of the second region of the sample.10-28-2010
20110267614ENGINEERED SERS SUBSTRATES EMPLOYING NANOPARTICLE CLUSTER ARRAYS WITH MULTISCALE SIGNAL ENHANCEMENT - Defined nanoparticle cluster arrays (NCAs) with total lateral dimensions of up to 25.4 μm by 25.4 μm have been fabricated on top of a 10 nm thin gold film using template guided self-assembly. This approach provides precise control of the structural parameters in the arrays allowing a systematic variation of the average number of nanoparticles in the clusters (n) and the edge to edge separation (Λ) between 111-03-2011
20110267612Hollow Core Photonic Crystal Fibre Comprising a Fibre Grating in the Cladding and Its Applications - An optical fibre is provided having a fibre cladding around a longitudinally extending optical propagation core. The cladding has a reflection region of a varying refractive index in the longitudinal direction.11-03-2011
20100141939METHODS OF POLARIZATION ENGINEERING AND THEIR APPLICATIONS - Special polarization states are generated that have unique focusing properties that may be used to create extremely strong longitudinal fields. Combined with surface plasmon excitation, these polarization states can be used in apertureless near-field scanning optical microscopy systems. A radially polarized beam is directed into a plasmon-generating optical fiber comprising a metal coated, tapered, apertureless tip. The apertureless tip excites surface plasmon waves and direct the surface plasmon waves to the tip when a radially polarized beam propagates along the plasmon-generating optical fiber. An objective lens collects the near field optical signals from a sample positioned adjacent to the apertureless. Potential spatial resolution of the apertureless NSOM could reach beyond 10 nm. Such strong field enhancement allows the development of a reliable nano-Raman system that can measure mechanical as well as chemical compositions of samples with resolution beyond 10 nm.06-10-2010
20090185181Method for measuring a surface plasmon resonance and noble metal compound used for the same - The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound.07-23-2009
20130120748OPTICAL FIBER SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) PROBE - A surface enhanced Raman spectroscopy (SERS) probe apparatus and a method of SERS probing employ Raman-active surfaces of a plurality of nanoscale field concentrator (NFC) structures at a terminal end of an optical fiber. The SERS probe apparatus includes an optical fiber having an optical path and a terminal end that terminates the optical path. The SERS probe apparatus further includes a plurality of NFC structures and nanoparticles on surfaces of the plurality of NFC structures. First ends of the NFC structures are adjacent to the terminal end of optical fiber. The nanoparticles are Raman active to an analyte.05-16-2013
20090135417OPTICAL BEAM SPECTROMETER - A spectroscopic system is described that provides at least one of focus of an excitation beam onto a sample, automatic focus of an optical system of the spectroscopic system for collecting a spectroscopic signal, and/or averaging of excitation intensity over a surface area of the sample.05-28-2009
20120069332METHOD AND SYSTEM FOR RAMAN, FLUORESCENCE, LITHOGRAPHIC, STIMULATED EMISSION AND PHOTOCHEMICAL IMAGING BEYOND THE DIFFRACTION LIMIT - Systems and methods for hyper-resolution beyond the diffraction limit of optical microscopes for applications in spectroscopy, absorption and lithographic photochemical patterning are described. These systems are based on interference of a pump pulse and a Stokes laser pulse which interfere to localize the population of an excited vibrational state in an area that is smaller than the scanning resolution of the microscope. Another (interfering) Stokes pulse has an annular shape at focus and destructively interferes with the the Stokes laser pulse. This destructive interference causes narrowing of the population distribution of the vibrational excited state well below the diffraction limit, which in turn localizes the population of the central electronic excited state by a separate actinic laser pulse having a lower energy than the ground state excitation energy of the molecule.03-22-2012
20120069331PLASMONIC ENHANCEMENT OF WHISPERING GALLERY MODE BIOSENSORS - A sensor for determining the presence or concentration of a target entity in a medium is described, and includes (a) an optical waveguide; (b) a microresonator optically coupled with the optical waveguide such that light within the optical waveguide induces a resonant mode within the microresonator at an equator region (or a mode volume); and (c) at least one plasmonic nanoparticle adsorbed onto a surface area of the microresonator within the equator region (or the mode volume) such that light inducing a resonant mode within the microresonator also causes a plasmonic resonance in the at least one plasmonic nanoparticle. Detection methods for using such sensors are also described. Finally, methods, involving the use of carousel forces, for fabricating such sensors are also described.03-22-2012
20090257056SURFACE ENHANCED RAMAN DETECTION ON METALIZED NANOSTRUCTURED POLYMER FILMS - Disclosed herein is a structure having a spatially organized polymer nanostructured thin film and a metal coating on the film. The thin film is made by directing a monomer vapor or pyrolyzed monomer vapor towards a substrate at an angle other than perpendicular to the substrate, and polymerizing the monomer or pyrolyzed monomer on the substrate.10-15-2009
20090257055HOLLOW-CORE WAVEGUIDE-BASED RAMAN SYSTEMS AND METHODS - Embodiments of the invention include a system for sensing homonuclear diatomic molecules, such as, for example, nitrogen. Other embodiments include a method for sensing homonuclear diatomic molecules. The system may include a light source, a hollow-core wave-guiding device that exhibits a low attenuation at predetermined operating optical frequencies and is in optical communication with the light source, a gas introduction system for introducing a gaseous medium between the light source and the hollow-core wave-guiding device, and a detector in optical communication with the hollow-core wave-guiding device.10-15-2009
20080316480AGGREGATES OF PLURAL TRANSITION METAL NANOPARTICLES AND PLURAL CYANINE DYE MOLECULES - The present invention is directed to an aggregate composed of a plurality of nanoparticles of a transition metal and a plurality of cyanine dye molecules that are interacting non-covalently. The nanoparticles are capped with a capping molecule, while the cyanine dye molecule can be cationic, anionic, or neutral cyanine dye. Methods of making such aggregates and for using them in detection of an analyte are also disclosed.12-25-2008
20090002698SYSTEM AND METHOD FOR THE ELECTROSTATIC DETECTION AND IDENTIFICATION OF THREAT AGENTS - A system and method for detecting aerosol threats comprising electrostatic collection and deposition of a threat agent onto a substrate. The threat agent deposited on the substrate is illuminated with a plurality of photons to thereby produce Raman scattered photons. The Raman scattered photons are analyzed in order to identify the threat agent.01-01-2009
20090251694Method and Apparatus for Conducting Raman Spectroscopy - A Raman probe system includes: a base station; a mobile robot remotely controllable from the base station; a Raman probe assembly supported by the robot, the Raman probe assembly including a laser and a spectrometer; a camera supported by the robot; and a communication subsystem operable to communicate images from the camera and results from the Raman probe assembly to the base station. In some embodiments, a Raman probe system includes: a mobile robot remotely controllable from a base station, the robot including a body and an articulated arm; a camera supported by the robot; a Raman probe assembly supported by the robot, the optical control assembly mounted on the body of the robot; and an optical probe mounted on the articulated arm of the robot; and a wireless communication system operable to communicate images from the camera and results from the Raman probe assembly to the base station.10-08-2009
20110222055DETERMINATION OF THE SALT CONCENTRATION OF AN AQUEOUS SOLUTION - A method of determining the concentration of a salt that may be present in a substance containing at least some water, comprising the following steps: a) recording the Raman spectrum of photons scattered by the substance in the wave number range 2500 cm09-15-2011
20110222054Apparatus and Method for Multi-Modal Imaging in Nonlinear Raman Microscopy - An apparatus for the microscopic examination of an object has an illumination system which generates a first illumination light beam and a second illumination light beam. A first polarization filter (09-15-2011
20090079978METHOD FOR DETECTING MOLECULAR ANALYSIS LIGHT, AND APPARATUS AND SAMPLE PLATE FOR USE WITH THE SAME - A molecular analysis light detection apparatus is formed by: a sample plate provided with an enhancing member which is disposed at a small predetermined area of a sample contact surface contacting with a sample containing a substance to be analyzed and which generates an enhancing field for enhancing light generated from the substance to be analyzed at the predetermined area relative to the light at other areas of the sample contact surface when predetermined excitation light is applied; an excitation-light applying optical system for applying the excitation light to an illumination area which contains the predetermined area of the sample contact surface provided with the enhancing member and which is larger than the predetermined area; and a signal detector unit for detecting fluctuation of the light, which is enhanced by the enhancing field, generated from the substance to be analyzed.03-26-2009
20090086201Surface Enhanced Raman Spectroscopy (SERS) systems for the detection of viruses and methods of use thereof - Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting and differentiating biomolecules of interest, such as human immunodeficiency virus (HIV), are provided.04-02-2009
20090097022DISCOVERY TOOL WITH INTEGRATED MICROFLUIDIC BIOMARKER OPTICAL DETECTION ARRAY DEVICE AND METHODS FOR USE - The present disclosure relates to the fields of microchips with microfluidic optical chambers with enhanced Raman surfaces for multiplexed optical spectroscopy. Embodiments of the present invention allow for ultra small sample volume, as well as high detection speed and throughput, as compared to conventional cuvettes or devices used in optical spectroscopy. Particular embodiments relate to scientific and medical research, the diagnosis of diseases such as cancer, cardiovascular disease, diabetes, etc., and specifically to the detection of biomarkers and determination of protein activity with relevant scientific and medical applications.04-16-2009
20090079977Calibrated Analyte Concentration Measurements in Mixtures - The concentration of analytes in a complex mixture can be ascertained by spectroscopic measurement, even if the spectra of substances other than the analyte overlap with that of the analyte. Both independently measured concentrations of the analyte in a training set and of the analyte spectrum are used. Variances in the spectral data attributable to the analyte are isolated from spectral variances from other causes, such as compositional changes associated with different samples that are independent of the analyte. For the special case of noninvasive glucose measurements on the skin of biological organisms, the volume averaged glucose in the sample is predicted from the blood glucose. A test for over-fitting of the data is also described.03-26-2009
20090021730METHOD AND APPARATUS FOR SUPER MONTAGE LARGE AREA SPECTROSCOPIC IMAGING - The disclosure relates to Method and Apparatus for Super Montage Large area Spectroscopic Imaging. In one embodiment of the disclosure, a method for producing a spectroscopic image of an object includes the steps of (a) irradiating the object with light to thereby produce from the object scattered and/or emitted (interchangeably “scattered”) light for each of a plurality of wavelengths; (b) producing separately for each of the plurality of wavelengths a plurality of substantially contiguous sub-images of the object; (c) compensating for spatial aberrations in ones of the sub-images for a select one of the plurality of wavelengths; (d) compensating for intensity aberrations between ones of the substantially contiguous sub-images for one of the plurality of wavelengths; and (e) combining the sub-images for the select one wavelength to thereby produce said spectroscopic image of the object.01-22-2009
20090086203Method for Correlating Spectroscopic Measurements with Digital Images of Contrast Enhanced Tissue - A system and method of correlating Raman measurements with digital images of a sample so to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set.04-02-2009
20090066946ARRAYS OF NANO STRUCTURES FOR SURFACE-ENHANCED RAMAN SCATTERING - Disclosed herein is a SERS sensing surface device comprising a substrate supporting a plurality of nano structures, an exposed sensing surface upon the nano structures, wherein said surface includes at least one active SERS nano surface and at least one inactive SERS nano surface established in proximity to the active SERS nano. Also disclosed are methods for forming the array device, systems based on the array device, as well as methods for performing SERS with the array device.03-12-2009
20090097023MOLECULAR DYE FOR SPECTROSCOPY - A method of detecting the presence, absence or quantity of a dye in a sample in a reaction region is provided, comprising the steps of providing a dye comprising a ligand ion complex, the ligand having a lowest unoccupied electron level and the ion having an excited electron level, the lowest unoccupied electron level of the ligand having an energy level such that an electron in the excited electron level of the ion may transfer non radiatively to the lowest unoccupied electron level of the ligand, the complex having a ground state electron level; illuminating the dye with a specified wavelength of radiation to detect the presence, absence or quantity of dye; detecting radiation from the illuminated dye; wherein the electron levels of the complex and the wavelength of the radiation are arranged such that electrons in the ground state are promoted to an excited state by photon absorption and it is energetically favourable for electrons to transfer to the lowest unoccupied electron level of the ligand from the excited electron level of the ion and undergo non-radiative relaxation via a thermally accessible electron level between the ground state electron level of the complex and the excited electron level of the ion to the ground state electron level.04-16-2009
20090097021Substrate and Substrate Assembly for Use in Raman Spectroscopic Analysis - To provide a substrate and a substrate assembly for Raman spectroscopic analysis that are capable of analyzing even a substance of a low concentration with high sensitivity.04-16-2009
20090097020MULTIPOINT METHOD FOR IDENTIFYING HAZARDOUS AGENTS - The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.04-16-2009
20090231578MULTI-CHANNEL FIBER OPTIC SPECTROSCOPY SYSTEMS EMPLOYING INTEGRATED OPTICS MODULES - The invention provides unitary optics modules that integrate several light management functions for performing optical spectroscopy, such as Raman spectroscopy, and optical spectroscopy systems that include one or more of the unitary optics modules. Methods of using the modules and systems are also provided.09-17-2009
20090231577METHOD AND APPARATUS FOR SURFACE ENHANCED RAMAN SPECTROSCOPY - A test cell comprises a test chamber at least partially enclosed by a wall. The test chamber holds a test fluid, and a test material is placed within the test chamber such that at least a portion of the test material is contact with the test fluid and at least a portion of the test material is in optical register with a window of the wall. A first conductive element is in electrical communication with the test fluid but is separated from the test material by a space, and extends to an outside of the cell. A second conductive element is in electrical communication with the test material and also extends to the outside of the cell.09-17-2009
20110228266 SUBSTRATE FOR SURFACE ENHANCED RAMAN SCATTERING (SERS) - A substrate for Surface Enhanced Raman Scattering (SERS). The substrate comprises at least one nanostructure protruding from a surface of the substrate and a SERS active metal over the at least one nanostructure, wherein the SERS active metal substantially covers the at least one nanostructure and the SERS active metal creates a textured layer on the at least one nanostructure.09-22-2011
20110228265PROCESS FOR THE DETERMINATION OF THE SOLID/LIQUID PHASE - A method of determining the solid/liquid phase of an aqueous solution, characterized in that it comprises the following steps: a) subjecting said aqueous solution to a beam of photons; b) recording the Raman spectrum of the photons scattered by said solution in the wave number range between 2500 cm09-22-2011
20110228264SERS Nanotags With Improved Buoyancy in Liquids - A suspendable SERS nanotag. As used herein, a suspendable tag is one which remains suspended in a specific liquid, water for example, for a period of time. Thus, a suspendable tag does not sink to the bottom of a container of the liquid or float to the top of a container of the liquid within the selected time period. A suspendable SERS nanotag may include a metal core, for example, an Au core having a diameter of less than 90 nm. The suspendable SERS nanotag may also include a SERS active reporter molecule associated with the core and a silica containing encapsulant, encapsulating the core and reporter association.09-22-2011
20090244534Mirror Adapted in Microscope to Perform SERS, a Microscope and Methods Thereof - The present invention relates to spectroscopy, more particularly relates to a mirror which is adopted in a microscope to perform Surface Enhanced Raman Spectroscopy [SERS].10-01-2009
20090244535CONTINUOUS MEASUREMENT OF AMINE LOADING IN GAS PROCESSING PLANTS USING RAMAN SPECTROSCOPY - The present invention provides a system and method for continuous measurement of acid gas concentration or amine loading in a basic solution using Raman spectroscopy.10-01-2009
20090213369Metallic Nanostructures Adapted for Electromagnetic Field Enhancement - The disclosure relates to metallic nanophotonic crescent structures, or “nanocrescent SERS probes,” that enhance detectable signals to facilitate molecular detections. More particularly, the nanocrescent SERS probes of the disclosure possess specialized geometries, including an edge surrounding the opening that is capable of enhancing local electromagnetic fields. Nanosystems utilizing such structures are particularly useful in the medical field for detecting rare molecular targets, biomolecular cellular imaging, and in molecular medicine.08-27-2009
20090244533Raman Analysis - Properties of turbid or scattering samples are determined using Raman spectroscopy with probe light delivered to and subsequently collected from the sample using a transmission geometry. The technique may be applied to pharmaceutical products such as tablets, diagnostic tests such as lateral flow diagnostic strips, and elsewhere.10-01-2009
20090219525SYSTEM AND METHOD FOR PORTABLE RAMAN SPECTROSCOPY - One embodiment includes a method that includes scanning a plurality of specimens with a laser by moving the laser according to coordinates for laser movement and measuring a distance for each of the plurality of specimens, associating location information with each of the specimens of the plurality of specimens based on its distance from the laser and its coordinates for laser movement, recording a Raman spectrum for the plurality of specimens, associating a Raman spectrum with each specimen of the plurality of specimens and indicating a Raman spectrum and location information for at least one specimen.09-03-2009
20090219524METHOD AND APPARATUS FOR CONTROLLED RAMAN SPECTROMETER - One embodiments includes a method that includes enabling an excitation laser during an excitation period, after a timed delay following the first excitation period, monitoring a photon scattering caused by the excitation laser, analyzing the photon scattering, automatically adjusting the timed delay to a modified timed delay based on the analyzed photon scattering and following the modified timed delay, enabling a Raman spectrometer to monitor Raman scattering caused by the excitation laser during a Raman monitoring period.09-03-2009
20090219526REAGENTS FOR BIOMOLECULAR LABELING, DETECTION AND QUANTIFICATION EMPLOYING RAMAN SPECTROSCOPY - The present disclosure provides isotopically substituted compounds of the formula (I):09-03-2009
20120105842METHODS FOR CALIBRATING A MEASUREMENT DEVICE, AND DEVICES THEREFROM - The invention provides a method of calibrating measurement device using a Raman-active composition, wherein the composition is active, in one embodiment, in a wavelength region that ranges from about 300 nm to about 1200 nm, and in another embodiment, from about 550 nm to about 650 nm. The method is especially useful in the calibration of fluorescent measurement devices. The method of the invention provides several advantages, such as, in facile identification of problems with the device when it occurs, in not having to tune and adjust the device very often, and neutralizing variations between different runs and different instruments. In another aspect, the invention also provides a device that is calibrated using the method of the invention. In one embodiment, the Raman-active composition useful in the invention is a derivative of 1,4-bis(2-methyl-styryl)-benzene.05-03-2012
20120105840SENSING DEVICE AND METHOD PRODUCING A RAMAN SIGNAL - A sensing device that produces a Raman signal includes micro-rods or nano-rods arranged on a substrate in a two-dimensional (2D) array, each of the rods having a length in a single row being substantially the same, with the rod length of each row being different from the rod length of each other row. Each row of rods has a respective resonant vibration frequency that varies from row to row. A source of vibration energy, operatively connected to the substrate, excites vibration in each of the rods such that a responding row resonates when an exciting frequency approaches the resonant vibration frequency of the responding row. A method includes exposing the 2D array to a light source and analyzing Raman scattering at each rod of the 2D array to render a Raman map.05-03-2012
20120105839Progressive Cut-Size Particle Trap and Aerosol Collection Apparatus - Improved centrifugal particle traps for aerosol particle collection and sampling characterized by a curved, progressively tapered impactor channel operable over a incompressible or compressible flow regime, or a flow regime transitioning from incompressible to compressible over the length of the particle trap. Mixtures of particles in a flowing gas stream are impactingly captured and separated by size. The particle traps can be operated to collect submicron particles without blockage, have lower pressure drops to reduce overall power requirements, and surprisingly, viability of biological particles captured in the particle traps of the invention is increased. Also disclosed are systems and methods combining these improved particle traps with in-line particle concentrators and with aerosol sample or liquid sample processing and analysis systems.05-03-2012
20120194812PHASE DETECTION OF RAMAN SCATTERED LIGHT - An apparatus for phase detection of Raman scattered light emitted from a sample includes a first polarizer positioned along a first optical path containing a first beam and a second polarizer positioned along a second optical path containing a second beam. The first polarizer and second polarizer polarize the first beam and the second beam in one of mutually perpendicular and mutually parallel first and second directions. The apparatus also includes an optical phase modulator positioned along the second optical path to controllably modulate a phase of the second beam, a beam splitter positioned to join the first beam and the second beam together, and a spectrometer to receive the joined first beam and second beam and to measure a phase shift of the first beam and the second beam.08-02-2012
20120194814Apparatus and Methods for Performing Raman Spectroscopy in Scattering Medium - An improved apparatus and method for performing Raman spectroscopy in a scattering medium, where the scattering induced phase modulation is compensated by using a spatial light modulator to shape the wavefront of the laser beam. This allows the laser beam to be focused to a spot inside the inhomogeneous material with low distortion, thus stimulating Raman signal from the focus point for spectral analysis.08-02-2012
20100014077METHOD FOR USING A PHOTONIC CRYSTAL FIBER AS A RAMAN BIOSENSOR - A method is provided for biosensing using a photonic crystal fiber having a hollow core. The method includes: designating an analyte of interest; determining a wavelength for an excitation light source which generates a Raman spectrum when incident upon the analyte of interest; selecting a photonic crystal fiber that would guide the light when the fiber is non-selectively filled with a solvent hosting the analyte of interest; non-selectively filling a photonic crystal fiber with the solvent hosting the analyte of interest; interrogating the analyte of interest by coupling light from the light source to the photonic crystal fiber; and analyzing the light output from the photonic crystal fiber for Raman fingerprints.01-21-2010
20120194815MEASUREMENT OF RAMAN RADIATION - An apparatus comprises a plurality of detecting elements and a summer. Each detecting element receives and detects different bands of spectrum of Raman radiation formed in response to at least one optical excitation pulse directed to the object. The detecting elements and/or the summer receives a command to enable registration of detections in the detecting elements and a command to disable the registration during or after the Raman radiation. The summer registers separately the detections of the Raman radiation in at least two detecting elements for presenting data on the object on the basis of the detections.08-02-2012
20100165335SYSTEMS AND METHODS FOR RECEIVING AND/OR ANALYZING INFORMATION ASSOCIATED WITH ELECTRO-MAGNETIC RADIATION - According to an exemplary embodiment, a system can be provided which can have at least one fiber arrangement and at least one receiving arrangement. The fiber arrangement may have optical transmitting characteristics, and may be configured to transmit there through at least one electromagnetic radiation and forward the at least one electromagnetic radiation to at least one sample. At least one portion of the fiber arrangement may be composed of or can include therein sapphire, diamond, clear graphite, Chalcogenide, borosilicate, zirconium fluoride, silver halide, a liquid core light guide, a gas core light guide, a hollow core waveguide, and/or a solid core photonic crystal fiber. The receiving arrangement may be configured to receive the electromagnetic radiation that is filtered and received from the sample. According to another exemplary embodiment, a method can be provided for obtaining information associated with the sample. For example, at least one first electromagnetic radiation can be forwarded to the sample via at least one optical fiber. At least one first characteristic of at least one portion of the optical fiber can be controlled so as to modify at least one second characteristic of at least one second electromagnetic radiation generated within the optical fiber. The second electromagnetic radiation can be associated with the first electromagnetic radiation.07-01-2010
20100149529METHODS OF FABRICATING SURFACE ENHANCED RAMAN SCATTERING SUBSTRATES - A method of fabricating a surface enhanced Raman scattering (SERS) substrate. In one embodiment, the method has the steps of simultaneously evaporating a metal at a first evaporation rate and a polymer at a second evaporation rate different from the first evaporation rate, to form a nanocomposite of the metal and the polymer, depositing the nanocomposite onto a substrate, and applying an etching process to the deposited nanocomposite on the substrate to remove the polymer material, thereby forming an SERS substrate.06-17-2010
20090279085LASER-PROCESSED SUBSTRATE FOR MOLECULAR DIAGNOSTICS - Surface enhanced Raman Scattering (SERS) and related modalities offer greatly enhanced sensitivity and selectivity for detection of molecular species through the excitation of plasmon modes and their coupling to molecular vibrational modes. One of the chief obstacles to widespread application is the availability of suitable nanostructured materials that exhibit strong enhancement of Raman scattering, are inexpensive to fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other photonic sensing that use semiconductor and metal surfaces fabricated using femtosecond laser processing. A noble metal film (e.g., silver or gold) is evaporated onto the resulting nanostructured surfaces for use as a substrate for SERS. These surfaces are inexpensive to produce and can have their statistical properties precisely tailored by varying the laser processing. Surfaces can be readily micropatterned and both stochastic and self-organized structures can be fabricated. This material has application to a variety of genomic, proteomic, and biosensing applications including label free applications including binding detection. Using this material, monolithic or arrayed substrates can be designed. Substrates for cell culture and microlabs incorporating microfluidics and electrochemical processing can be fabricated as well. Laser processing can be used to form channels in the substrate or a material sandwiched onto it in order to introduce reagents and drive chemical reactions. The substrate can be fabricated so application of an electric potential enables separation of materials by electrophoresis or electro-osmosis.11-12-2009
20090279084Optical Sensor and Method for Manufacturing the Same - An optical sensor according to the present invention significantly enhances the sensitivity of an optical sensor for molecular measurement using light such as Surface Enhanced Raman Scattering and Plasmon Resonance Spectroscopy utilizing the local plasmon's excitation of a noble metal. By using a transparent substance deposition step for forming a large number of anisotropic nano-columns having a predetermined aspect ratio, with their longitudinal direction and transverse direction aligned, by depositing a transparent substance onto a substrate from an oblique position while periodically inverting the position and a noble metal deposition step for depositing a noble metal onto surfaces of the formed anisotropic nano-columns, it is possible to manufacture an optical sensor with very high sensitivity at very low cost.11-12-2009
20110128538System for Generating Raman Vibrational Analysis Signals - A system for generating signals for Raman vibrational analysis, particularly for a CARS microscope or spectroscope of an external specimen, the system comprising a a laser source apt to emit at least one fundamental optical pulse in a first band of fundamental frequencies comprising at least one first (ω06-02-2011
20100165336Applications of laser-processed substrate for molecular diagnostics - Surface enhanced Raman Scattering (SERS) and related modalities offer greatly enhanced sensitivity and selectivity for detection of molecular species through the excitation of plasmon modes and their coupling to molecular vibrational modes. One of the chief obstacles to widespread application is the availability of suitable nanostructured materials that exhibit strong enhancement of Raman scattering, are inexpensive to fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other photonic sensing that use semiconductor and metal surfaces fabricated using femtosecond laser processing. A noble metal film (e.g., silver or gold) is evaporated onto the resulting nanostructured surfaces for use as a substrate for SERS. These surfaces are inexpensive to produce and can have their statistical properties precisely tailored by varying the laser processing. Surfaces can be readily micropatterned and both stochastic and self-organized structures can be fabricated. This material has application to a variety of genomic, proteomic, and biosensing applications including label free applications including binding detection. Using this material, monolithic or arrayed substrates can be designed. Substrates for cell culture and microlabs incorporating microfluidics and electrochemical processing can be fabricated as well. Laser processing can be used to form channels in the substrate or a material sandwiched onto it in order to introduce reagents and drive chemical reactions. The substrate can be fabricated so application of an electric potential enables separation of materials by electrophoresis or electro-osmosis.07-01-2010
20100165334SPECTROSCOPIC DEVICE AND RAMAN SPECTROSCOPIC SYSTEM - A Raman spectroscopic device includes an optical resonator, in which a first reflecting body that exhibits semi transmissivity/semi reflectivity and has a surface which is a light scattering surface that generates Raman scattering, a transparent body, and a second reflecting body that exhibits reflectivity, are laminated in sequence one on another. The Raman spectroscopic device utilizes light absorption due to resonance to obtain a surface amplified Raman effect.07-01-2010
20100020317Method for Characterizing X-Ray Detector Materials Using a Raman Microscope - An improved Raman microspectrometer system extends the optical reach and analysis range of an existing Raman microspectrometer to allow analysis and/or repair of an oversized sample. The improved Raman microspectrometer system includes an extender for extending the optical reach of the existing microspectrometer and a supplemental stage which extends the analysis range of the existing microspectrometer by providing travel capabilities for non-destructive analysis of an entire oversized sample. Such an arrangement decreases manufacturing costs associated with testing oversized samples such as mammography panels, enabling analysis and/or repair to be performed without destruction.01-28-2010
20100002228Method and Apparatus for Conducting Raman Spectroscopy - Disclosed herein are Raman probes that include: (a) a first optical fiber for receiving laser excitation light from a light source and transmitting the same; (b) a first filter for receiving light from the first optical fiber and adapted to pass the laser excitation light and to block spurious signals associated with the light; (c) a second filter for receiving light from the first filter and adapted to direct the light toward a specimen; and (d) focusing apparatus for receiving the light from the second filter, focusing the light on the specimen so as to generate the Raman signal, and returning the Raman signal to the second filter. The second filter is further configured so that when the second filter receives the Raman signal from the focusing apparatus, the second filter filters out unwanted laser excitation light before directing the Raman signal to a second optical fiber.01-07-2010
20100177307METHOD AND OPTICAL ARRANGEMENT FOR GENERATING A NONLINEAR OPTICAL SIGNAL ON A MATERIAL WHICH IS EXCITED BY AN EXCITATION FIELD, AND USE OF THE METHOD AND OF THE OPTICAL ARRANGEMENT - The invention concerns a method of and an optical arrangement (07-15-2010
20120062883CRYSTALLINE COLLOIDAL ARRAY DEEP UV NARROW BAND RADIATION FILTER - The present invention provides a method of making highly charged, monodisperse particles which do not absorb deep ultraviolet (UV) light and a method of making crystalline colloidal array (CCA) deep UV narrow band radiation filters by using these highly charged monodisperse particles. The CCA filter rejects and/or selects particular regions of the electromagnetic spectrum while transmitting adjacent spectral regions. The filtering devices of the present invention are wavelength tunable over significant spectral intervals by changing the incident angle of the CCA filter relative to the light. Larger wavelength changes can be obtained by changing the concentrations of particles in the CCAs. The present invention also includes applications of the CCA filter to hyperspectral imaging and Raman imaging devices.03-15-2012
20130215421METHODS AND APPARATUS FOR CONTROLLED GENERATION OF HYPERFINE POLARIZATIONS AND COHERENCES - Methods and apparatus that provide for precise and continuously-controlled generation of hyperfine polarizations and coherences in samples of laser cooled atoms. In one example, coherent population trapping induced by Raman pulses with preselected parameters (such as phase and duration) is employed as a mechanism for producing well-controlled atomic coherences and polarizations. In one example, these coherences and polarizations are used to provide precision polarization references for normalization of polarization readout measurements.08-22-2013
20130215422OPTICAL APPARATUS - A signal is amplified by making a CARS beam from an observed body and a reference beam which is a portion of a super continuum beam and has a frequency of ω08-22-2013
20100208253Multi-Modal Surface Plasmon Polariton - Raman Scattering Based Bio-Detection - Methods and systems for combined SPP and Raman scattering-based bio-detection are provided. Embodiments include a bio-detection system having a microfluidics chip, a Surface Plasmon Polariton (SPP)-based system component, and a Raman scattering-based system component. The SPP-based and the Raman scattering-based system components can be used simultaneously or individually separately to detect biological and/or chemical analytes. The bio-detection system further includes an aerosol collector chip. Embodiments of the present invention can be used aboard means of propagation of biological and/or chemical analytes, including, for example, commercial aircrafts. Embodiments of the present invention can be used to enable an aircraft warning system.08-19-2010
20100253940STRUCTURE FOR SURFACE ENHANCED RAMAN SPECTROSCOPY - A structure for surface enhanced Raman spectroscopy is disclosed herein. A substrate has a stack configured vertically thereon. The stack encompasses at least two metal layers and at least one dielectric layer therebetween. Each layer of the stack has a controlled thickness, and each of the at least two metal layers is configured to exhibit a predetermined characteristic of plasmonic resonance.10-07-2010
20120194813SENSOR CHIP FOR BIOMEDICAL AND MICRO-NANO STRUCTURED SUBSTANCES AND METHOD FOR MANUFACTURING THE SAME - The present invention relates to a sensor chip for biomedical and micro-nano structured substances and a method for manufacturing the same. The sensor chip includes plural metal nanoparticles and a porous anodized aluminum oxide film. The plural metal nanoparticles are completely contained in holes of the porous anodized aluminum oxide film and located at the bottom of the holes, and an aluminum oxide layer covering the second end of the holes has a thickness of 1 nm to 300 nm. When analytes such as biomedical molecules are provided in contact with the sensor chip, a Raman signal can be detected based on the Raman spectroscopy. The structure of the sensor chip of the present invention is uncomplicated and the manufacturing steps thereof are simple, and therefore the sensor chip of the present invention is of great commercial value. Also, a method of manufacturing the above sensor chip is disclosed.08-02-2012
20090002701Electric-field-enhancement structure and detection apparatus using same - Various aspects of the present invention are directed to electric-field-enhancement structures and detection apparatuses that employ such electric-field-enhancement structures. In one aspect of the present invention, an electric-field-enhancement structure includes a substrate having a surface. The substrate is capable of supporting a planar mode having a planar-mode frequency. A plurality of nanofeatures is associated with the surface, and each of nanofeatures exhibits a localized-surface-plasmon mode having a localized-surface-plasmon frequency approximately equal to the planar-mode frequency.01-01-2009
20090040517RAMAN DIFFERENCE SPECTRA BASED DISEASE CLASSIFICATION - A method to diagnosis a disease state of an unknown sample. A test Raman data set for an unknown sample is generated. A reference Raman database is provided where the database contains a plurality of reference Raman data sets and a plurality of reference Raman difference data sets. The reference Raman difference data set is generated by determining a difference between a first reference Raman data set and a second reference Raman data set. A first reference Raman data set is associated with first known sample and associated with one or more of: a first known disease state and a first known clinical outcome. A second reference Raman data set is associated with a second known sample and associated with one or more of: a second known disease state and a second known clinical outcome. A diagnosis is provided of whether the unknown sample has a first disease state or a second disease state by comparing the test Raman dataset to said plurality of reference Raman difference data sets in the reference Raman database using a chemometric technique.02-12-2009
20090323058LASER MICROSCOPE WITH A PHYSICALLY SEPARATING BEAM SPLITTER - The invention proposes a method for imaging at least one microscopic property of a sample and an apparatus with which the proposed method can be carried out. In the method, at least one coherent illumination light with at least one illumination wavelength is produced by means of at least one light source. The illumination light is imaged onto at least one region on or within the sampled. Detection light emitted by the sample is split at least partially into incoherent detection light and into coherent detection light by means of at least on physically separating beam splitter. The coherent detection light is at least partially separated from the coherent illumination light by at least one beam-splitter element. The coherent detection light is detected. The proposed method can be used in particular for investigating the sample by means of coherent anti-Stokes-Raman scattering.12-31-2009
20090323057RAMAN SPECTROSCOPY SYSTEM AND RAMAN SPECTROSCOPY DETECTION METHOD - The present invention relates to a Raman spectroscopy system that includes a detection center. The detection center includes at least one light source for outputting exciting light which excites a detected object to generate Raman scattered light, and an analysis device for obtaining the Raman spectroscopy of the detected object. The Raman spectroscopy system further includes at least one detection terminal, each of which includes at least one Raman probe that each introduces the exciting light to the detected object, collects the Raman scattered light generated by the detected object, and returns said Raman scattered light to the detection center. The present invention also relates to a method for detecting Raman spectroscopy.12-31-2009
20090033929SUBSTRATES FOR RAMAN SPECTROSCOPY HAVING DISCONTINUOUS METAL COATINGS - In one aspect, the present invention provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with discontinuous metal coating characterized by one or more metalized surface region and a plurality of surface gaps.02-05-2009
20100309463SPECULAR INTEGRATING TUBE FOR SCATTERED-LIGHT SPECTROSCOPY - A scattered-light spectroscopy system for collecting light scattered from a sample, e.g. Raman-scattered light, to produce a spectrum of the sample, includes a cylindrical cell for holding the sample that is transparent and coated on either its inside surface or outside surface with a reflective coating, e.g. aluminum. The reflective coating has an opening for aligning with an aperture in a spectrometer for receiving the sample-scattered light. Light from a source such as a laser illuminates the sample to produce a scattered light having a first part received directly at the opening and a second part reflected by the reflective coating one or more times prior to arrival at the opening, thereby adding to the total scattered light entering the aperture of the spectrometer to improve its collection efficiency.12-09-2010
20130135615STIMULATED RAMAN SCATTERING MEASUREMENT APPARATUS - The measurement apparatus combines first and second lights from first and second light generators to focus the combined light to a sample, and detect the first or second light intensity-modulated by stimulated Raman scattering. The first light generator includes a light dispersion element separating the light from a light introducing optical system in different directions according to light frequencies, and drives at least one of the light dispersion element and part of the light introducing optical system so as to change an incident angle of the light to the light dispersion element to extract part of the separated light, thereby making a light frequency of the first light variable. The second light generator produces a plurality of the second lights having mutually different light frequencies. The apparatus measures a Raman spectrum by changing the light frequency of the first light.05-30-2013
20100315630METHOD AND SYSTEM FOR ESTIMATING FLUID LEAK FLOW RATES USING DISTRIBUTED OPTICAL FIBER SENSORS - A leak detection system and method is provided for a structure having a first barrier to a first fluid and a second barrier to a second fluid, the first barrier and the second barrier defining a space therebetween. The system includes at least one sensor, such as a fiber optic sensor, placed in the space and configured to detect presence of the first fluid or the second fluid in the space due to a fluid leak in the first barrier or the second barrier. The fiber optic sensor may further be configured to measure one or more characteristics of an acoustic emission caused by the leak, and the system and method may be able to estimate the orifice diameter of the fluid leak based on the measured one or more characteristics, and to calculate a leak rate based on the estimated orifice diameter.12-16-2010
20110122407APPARATUS AND METHOD FOR MULTIPLE-PULSE IMPULSIVE STIMULATED RAMAN SPECTROSCOPY - Spectroscopic measurements are described based on light-molecule interaction in response to a resonant rate optical pulse train so that a Raman spectrum is reflected containing at least two types of vibrational mode information (e.g., vibrational frequency, and vibrational phase relaxation) on the molecules comprising the object. A pump optical pulse train generation means is configured for generating an optical pulse train having an arbitrary repetition rate which is directed through irradiation means to the sample object. Light from the sample object is collected and vibrational coherence is detected for the sample object. The sample is tested across a plurality of different repetition frequencies. The detected information can be compared with data from other known samples from within a database when analyzing the information collected.05-26-2011
20100315631Raman Spectroscopic Apparatus Utilizing Self-Aligned Non-Dispersive External Cavity Laser - A Raman spectroscopic apparatus utilizing a self-aligned non-dispersive external cavity laser as the excitation light source. The output spectrum of the laser is narrowed and stabilized by a volume Bragg grating to provide high spectral brightness. A high throughput optical system is used for Raman scattering signal excitation and extraction, which takes full advantage of the high spectral brightness of the laser source.12-16-2010
20100315629Optical Scanning - Disclosed are apparatus, kits, methods, and systems that include a radiation source configured to direct radiation to a sample; a detector configured to measure radiation from the sample; an electronic processor configured to determine infotmation about the sample based on the measured radiation; a housing enclosing the source, the detector, and the electronic processor, the housing having a hand-held form factor; an arm configured to maintain a separation between the sample and the housing, the arm including a first end configured to connect to the housing and a second end configured to contact the sample; and a layer positioned on the second end of the arm, the layer being configured to contact the sample and to transmit at least a portion of the radiation from the sample to the detector.12-16-2010
20100315628ARRANGEMENT AND METHOD FOR ANALYSIS OF BIOLOGICAL SAMPLES - The invention lies in the technical field of cell biology and transplantation medicine. It concerns devices and methods for rapid and noninvasive analysis or checking of biological samples, especially for sterility control, for characterization of infectious particles and microorganisms contained in the biological sample and for characterization of tissue cells and transplants. The main areas of application of the invention are biotechnological production of pharmacological active ingredients and therapeutic agents as well as transplantation medicine.12-16-2010
20110001963SYSTEM AND METHOD FOR THE MEASUREMENT OF MULTIPLE EMISSIONS FROM MULTIPLE PARALLEL FLOW CHANNELS IN A FLOW CYTOMETRY SYSTEM - A system and method for the measurement of multiple emissions in multiple flow channels in a flow cytometry system is disclosed where each excitation source is modulated with a different frequency. A single detector is used to collect the fluorescent emissions excited by all sources in all flow channels, and the emissions are segregated using Fourier Transform techniques. The system and method are well-suited to microfluidic applications.01-06-2011
20110001964PHOTO ACOUSTIC SAMPLE DETECTOR WITH BACKGROUND COMPENSATION - A photo acoustic detector for detecting a concentration of a sample in a sample mixture, the photo acoustic detector has a light source for producing a light beam for exciting molecules of the sample, a light modulator for modulating an intensity of the light beam for generating pressure variations in the sample mixture, an amplitude of the pressure variations being a measure of the concentration of the sample, and an acoustic cell with an acoustic resonator for amplifying the pressure variations. Furthermore, the photo acoustic detector has a resonant pickup element for converting the pressure variations inside the acoustic resonator into a detector signal, and a processing section for processing the detector signal to generate 1) a sample signal caused by the pressure variations, and 2) a background signal caused by direct excitation of the pickup element by the light beam. The acoustic cell and the pickup element are arranged in such a way that a phase difference between the background signal and the sample signal is close to 90 degrees.01-06-2011
20110128537METHODS AND SYSTEMS FOR RAMAN AND OPTICAL CROSS-INTERROGATION IN FLOW-THROUGH SILICON MEMBRANES - Cross-interrogating photonic detection systems and methods are shown. A flow through photonic crystal membrane with a surface enhanced Raman scattering (SERS) substrate is provided with pores which are distributed along multiple regions. The pores of one region have walls to which a first type of target specific anchor can be attached, while pores of another region have walls to which a second type of target specific anchor can be attached. An optical arrangement out-of-plane to the SERS substrate is also provided for enhanced sensitivity and identification of target organisms.06-02-2011
20110128535Nano-Structured Substrates, Articles, and Methods Thereof - A nano-porous composition, a substrate thereof, and an article thereof, that can be used, for example, for Surface Enhanced Raman spectroscopy (SERS), and like applications. The disclosure also provides methods of making the nano-porous compositions, articles, and methods for SERS imaging, as defined herein.06-02-2011
20110128536NANOSCALE ARRAY STRUCTURES SUITABLE FOR SURFACE ENHANCED RAMAN SCATTERING AND METHODS RELATED THERETO - Methods for fabricating nanoscale array structures suitable for surface enhanced Raman scattering, structures thus obtained, and methods to characterize the nanoscale array structures suitable for surface enhanced Raman scattering. Nanoscale array structures may comprise nanotrees, nanorecesses and tapered nanopillars.06-02-2011
20100171949NON-INVASIVE OPTICAL ANALYSIS USING SURFACE ENHANCED RAMAN SPECTROSCOPY - In one aspect, a system for use in product packaging is disclosed that includes a polymeric sensing substrate coupled to a package such that a front sensing surface thereof is in contact with a portion of a product, e.g., a fungible product, stored in the package and a back surface thereof is accessible via an environment external to the package. The system further includes a radiation source adapted to direct radiation to the substrate's back surface such that the radiation would interact with one or more molecular species of the product that are in contact with the substrate's sensing surface. The system also includes a detector that is adapted to detect radiation returning from the substrate in response to its illumination by the radiation source. The front surface of the sensing substrate can comprise a plurality of micron-sized or submicron-sized ridges having a discontinuous or continuous metal coating, e.g., a metallic layer with a thickness in a range of about 10 nm to about 1000 nm (and preferably in a range of about 50 nm to about 120 nm), disposed thereon.07-08-2010
20110043800Residual Chemical Monitoring System Using Surface Enhanced Raman Spectroscopy - Target chemicals are monitored at very low concentrations in pipelines or vessels such as storage tanks using surface enhanced Raman spectroscopy analysis of a sample. A liquid sample having a target chemical such as biocides, corrosion inhibitors, scale inhibitors, anti-foaming agents, emulsion breakers, and hydrate inhibitors are tested while exposed to a prepared and charged surface of a coupon so as to draw the target material to the prepared and charged surface. The charged surface is fairly precisely charged using two other electrodes to calibrate the charge on the surface of the coupon. With the target substance presumably drawn to the coupon, the molecules on the surface of the coupon are excited by monochromatic light such as from a laser to induce vibrations within the molecules. The vibrations of the molecules reflect and scatter the monochromatic light in distinctive manners such that the collected light from the surface provides an indication of the presence of the target substance in the sample and a quantitative indication of the concentration of the target material in the sample. With the ability at lower power and reasonable cost to sense the presence well down below one percent and into the ppm range provides the opportunity to more precisely and efficiently add such chemicals to operating pipelines and storage tanks.02-24-2011
20110116089SERS SUBSTRATE AND A METHOD OF PROVIDING A SERS SUBSTRATE - A substrate primarily for SERS determination, the substrate has a number of elongate elements with a density of at least 1×1005-19-2011
20100321684SIGNAL-AMPLIFICATION DEVICE FOR SURFACE ENHANCED RAMAN SPECTROSCOPY - A signal-amplification device for surface enhanced Raman spectroscopy (SERS). The signal-amplification device includes a non-SERS-active (NSA) substrate, a plurality of multi-tiered non-SERS-active nanowire (MNSANW) structures and a plurality of metallic SERS-active nanoparticles. In addition, a MNSANW structure of the plurality of MNSANW structures includes a main arm of a plurality of main arms and a plurality of arms of at least secondary order. The plurality of main arms is disposed on the NSA substrate; and, a secondary arm of the plurality of arms is disposed on the main arm. Moreover, a metallic SERS-active nanoparticle of the plurality of metallic SERS-active nanoparticles is disposed on a surface of the MNSANW structure.12-23-2010
20090323056METHODS, ARRANGEMENTS AND SYSTEMS FOR OBTAINING INFORMATION ASSOCIATED WITH A SAMPLE USING OPTICAL MICROSCOPY - Exemplary embodiments of methods, arrangements and systems for obtaining information about a sample can be provided. For example, in one exemplary embodiment, it is possible to receive a first electro-magnetic radiation from a sample which is based on a second electro-magnetic radiation forwarded to the sample. The first electro-magnetic radiation may have a first frequency and the second electro-magnetic radiation may have a second frequency which is different from the first frequency. The difference between the first and second frequencies can be based on an acoustic wave inside the sample related to at least one characteristic of the sample. Further, it is possible to receive at least a portion of the first electromagnetic radiation and separate it into a particular finite number (N) of frequency component radiations. In addition, it is possible to receive a particular energy of more than 1/N of energy of the third electro-magnetic radiation, and generate information associated with the sample. Certain exemplary embodiments of the present invention are capable of obtaining information associated with a sample, particularly its mechanical properties, non-contact using electromagnetic radiation.12-31-2009
20110085165System and Method for Combined Raman and LIBS Detection - A system and method for detection and identification of unknown samples using a combination of Raman and LIBS detection techniques. A first region of a sample and a second region of a sample are illuminated using structured illumination to thereby generate a first plurality of interacted photons and a second plurality of interacted photons. This first plurality and second plurality of interacted photons may be passed through a fiber array spectral translator device. Said first plurality of interacted photons are assessed using Raman spectroscopy to thereby generate a Raman data set. Said second plurality of interacted photons are assessed using LIBS spectroscopy to thereby generate LIBS data set. These data sets may be analyzed to identify the sample. These data sets may also be fused for further analysis.04-14-2011
20110063611QUANTUM EFFICIENCY ENHANCEMENT DEVICE FOR ARRAY DETECTORS - Systems and methods for increasing the quantum efficiency of a photocathode used in an intensified an intensified array detector with a photocathode, such as a charge-coupled device (ICCD) are presented. A quantum efficiency enhancement device is disposed in front of an ICCD and is configured to enable or facilitate an increase in the angle of incidence of incoming rays incident on the photocathode. The ICCD itself may be tilted to achieve an increased angle of incidence, and such tilting is preferably only in a direction in which pixel columns of the ICCD extend such that a plane of incidence of incoming light to the ICCD is perpendicular to a direction of wavelength dispersion. The quantum efficiency enhancement device may include re-imaging optics, an optical tilt compensator and optical coupler.03-17-2011
20100014076Spectrometric apparatus for measuring shifted spectral distributions - This invention relates to a spectroscopic apparatus for measuring at least two spectrally shifted spectral distributions of a light beam, said apparatus comprises a dispersive element adapted to generate a spatial dispersion of the spectral components in a light beam when said dispersive element is being illuminated by said light beam; and a detector adapted to measure the intensity of at least a part of said dispersed spectral components where said apparatus further comprises an optical shifting means adapted to illuminate said dispersive element in at least two different ways, such that said light beam hits said dispersive element differently, and whereby said dispersive element generates at least two spatially shifted spatial dispersions of the spectral components in said light beam. The invention further relates to a probing system comprising said spectroscopic apparatus for measuring at least two spectrally shifted spectral distributions of a light beam, and a method for measuring at least two spectrally shifted spectral distributions of a light beam.01-21-2010
20110176130LIQUID CORE PHOTONIC CRYSTAL FIBER BIOSENSORS USING SURFACE ENHANCED RAMAN SCATTERING AND METHODS FOR THEIR USE - The invention is drawn to a photonic crystal fiber that can be used with nanoparticles to detect and quantify components in a test sample. The invention further relates to methods of using the photonic crystal fiber for detecting chemical and biological analytes, and in use in optical communications.07-21-2011
20100134793OPTICAL EVALUATION METHOD BY MEANS OF LASER PULSES AND CORRESPONDING APPARATUS - An optical evaluation method and an apparatus for performing said method are described. First laser pulses of a first type and second laser pulses of a second type that differs from the first type are sent onto a sample to be examined. The sample is hit with first incident light from the two laser pulses in at least one manner of simultaneously, within a very short time lag between the two laser pulses, and a time-correlated manner of the two laser pulses, thereby generating a first optical signal, and hit with second incident light from the two laser pulses, thereby generating a second optical signal. The generated first and second optical signals are detected with at least one detector; and an electronic difference between the first and second optical signals is generated.06-03-2010
20100134792SPECTROSCOPIC IMAGING METHOD AND SYSTEM FOR EXPLORING THE SURFACE OF A SAMPLE - A spectroscopic imaging system includes a microscopic or macroscopic device including an objective, a housing including a spectroscope, and scanning means disposed between the objective and the spectroscope. During the scanning of the excitation beam on a scanned area on the sample surface, the energy of the emitted light beam is integrated on the pixels of the detection means, generating average spectral data for each line of pixels. Storage means are connected to the detection means, including a memory able to store average spectral data of M lines of pixels. An imaging device is connected to the storage means, and the average spectral data of M lines of pixels are sent simultaneously toward the imaging device in order to obtain an average spectroscopic image of the scanned area.06-03-2010
20090027668Chip for raman scattering enhancement and molecular sensing device including the chip - The present invention aims to provide a chip applied to a molecular sensing device which carries out Raman spectroscopic analysis utilizing Raman scattering enhancement due to plasmons, and that achieves higher sensitivity and stability of its sensing sensitivity and miniaturization, and to provide a molecular sensing device including the chip. As the chip for Raman scattering enhancement applied to the molecular sensing device using the Raman spectroscopic analysis, which has an excitation light source for Raman scattering, a chip for Raman scattering enhancement and a photodetector for observing the Raman scattering, the present invention employs a chip having a molecular detecting element in which a transparent protection material thin film 01-29-2009
20090027667BIOSENSOR LABELLING GROUPS - A class of compounds specifically designed to act as resonance Raman spectroscopy labels, particularly surface-enhanced resonance Raman spectroscopy (SERRS) labels, for analytes such as proteins, peptides, nucleic acids, and related molecules is described. A resonance Raman spectroscopy label of the invention comprises a metallocene covalently attached to: a reactive group for covalent attachment of the label to an analyte; a SERRS surface binding group; and a halogen, wherein attachment of the halogen to the metallocene is such that the halogen causes a characteristic Raman peak to be produced when the label is subjected to resonance Raman spectroscopy. In a preferred aspect the label also has redox properties suitable for a second use as a label for electrochemical sensing.01-29-2009
20120200851RAMAN SPECTROSCOPY LIGHT AMPLIFYING STRUCTURE - A light amplifying structure 08-09-2012
20120120393TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTOR - A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.05-17-2012
20120120392Non-traditional agent/dusty agent detection system - A chemical agent detection system is described. The system comprises a sample introduction module, an agent concentration module and a detection module. The sample introduction module comprises a sample collector that collects particles and aerosols from a sample, and a heater that vaporizes the collected particles and aerosols and produces a sample vapor. The agent concentration module comprises a sorbent tube filled with a sorbent material that preferentially absorbs the vapor of a target chemical agent when the sample vapor passes through the sorbent tube. The detection module interrogates the sorbent material and identifies the target chemical agent absorbed to the sorbent material. Also disclosed are methods for detecting a non-traditional agent (NTA) or a dusty agent (DA), and trace levels of chemical warfare agents (CWA) and toxic industrial chemical (TIC) vapors.05-17-2012
20110069308Methods of Melamine detection and quantification - Embodiments of the present disclosure relate to methods of melamine detection and quantification. In particular, embodiments of the present disclosure include the detection of very low concentrations of melamine using silver nanorod array substrates fabricated by oblique angle deposition (OAD) technique.03-24-2011
20120200850CYTOLOGICAL METHODS FOR DETECTING A CONDITION SUCH AS TRANSPLANT EFFICIENCY BY RAMAN SPECTROSCOPIC IMAGING - Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. The disclosure includes the use of RMI to detect transplanted and/or grafted cells, to differentiate between normal and diseased cells or tissues, as well as in determining the grade of said cancer cells. Raman scattering data may be analyzed to determine the transplant efficiency, disease state, clinical outcome, and/or prognosis of cells or tissue. This data may be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view. Also, RMI techniques may be combined with visual image data and validated with other detection methods to produce confirm the matter obtained by RMI.08-09-2012
20100315632OPTICAL APPARATUS FOR COMBINED HIGH WAVENUMBER RAMAN SPECTROSCOPY AND SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY - The present invention provides apparatuses and methods for sample analysis, such as tissue analysis, that integrate high wavenumber (HW) Raman spectroscopy for chemical composition analysis and spectral-domain optical coherence tomography (SD-OCT) to provide depth and morphological information. Intravascular catheter embodiments and related vascular diagnostic methods are also provided.12-16-2010
20100302535All Reflective Apparatus for Injecting Excitation Light and Collecting In-elastically Scattered Light from a Sample - An apparatus is disclosed wherein laser radiation illuminates a sample using all reflective optics and wherein in-elastically scattered light from the sample is collected using the identical elements. The apparatus obviates the problem of contaminating the laser radiation with unwanted spectra from transmissive optics while providing very high rejection of the laser radiation with respect to the in-elastically scattered light. In addition, the apparatus can collect and launch light with high numerical aperture and large field of view.12-02-2010
20110026019METHOD FOR THE FORMATION OF SERS SUBSTRATES - A method for the formation of surface enhanced Raman scattering substrates. The method produces thin substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink such as silver, gold or copper nanoparticle ink which includes stabilized nanoparticles. The substrates and nanoparticle ink undergo a first step of heating in order to remove liquid vehicle from the ink. The substrates and nanoparticles then undergo a second step of heating for an amount of time sufficient to remove a substantial portion of the stabilizer and provide a fractal aggregate nanoparticle layer on the substrate having a certain resistivity or conductivity suitable for Raman scattering. This creates SERS substrates with enhanced amplification properties.02-03-2011
20110026018BIOLOGICAL AND CHEMICAL MICROSCOPIC TARGETING - Biological and chemical materials often contain many molecular bonds that connect carbon (C) hydrogen (H) atoms. These bonds covalently share electrons that can be optically activated by light. The incident light interaction with the C—H molecular bond spectrally shifts of the incident light proportional to the vibrational, or more precisely polarizability, constant of the electrons that bind the C—H atoms. This process is called Raman scattering. For C—H, C—H02-03-2011
20110037977Calibrated Analyte Concentration Measurements in Mixtures - The concentration of analytes in a complex mixture can be ascertained by spectroscopic measurement, even if the spectra of substances other than the analyte overlap with that of the analyte. Both independently measured concentrations of the analyte in a training set and of the analyte spectrum are used. Variances in the spectral data attributable to the analyte are isolated from spectral variances from other causes, such as compositional changes associated with different samples that are independent of the analyte. For the special case of noninvasive glucose measurements on the skin of biological organisms, the volume averaged glucose in the sample is predicted from the blood glucose. A test for over-fitting of the data is also described.02-17-2011
20110037976FLEXIBLE SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SUBSTRATES, METHODS OF MAKING, AND METHODS OF USE - Flexible SERS substrates, methods of making flexible SERS substrates, and methods of using flexible SERS substrates are disclosed.02-17-2011
20110037975METHOD FOR CALIBRATING IMAGING SPECTROGRAPHS - Disclosed is a method for calibrating optical spectrographs, and in particular optical spectrographs having focal plane array detectors. The method comprises the steps of detecting a spectrum of a known source, referencing a table of known spectral wavelengths and relative intensities, and deriving a spectrograph model based on the spectrograph's physical properties to approximate the observed spectrum, wherein non-linear optimization techniques refine the theoretical model parameters, thereby minimizing the residual difference between observed and calculated spectral intensities in an iterative process producing a set of physical model parameters that best describe the modeling spectrograph for calibration of subsequent spectral acquisitions.02-17-2011
20100027000Hybrid Technique for Coherent Anti-Stokes/Stokes Raman Spectroscopy - A method and system provide coherent anti-Stokes Raman spectroscopy. In an embodiment, the system includes a detection system for measuring coherent anti-Stokes Raman signals of a sample. The system includes a first light pulse and a second light pulse. The first light pulse and the second light pulse are operable to initiate coherent vibration in the sample. The system also includes a third light pulse. The third light pulse is a probe pulse that is operable to produce scattered radiation from the sample. In addition, the system includes a spectral filter. The spectral filter shapes the probe pulse. The system further includes a detector to record the spectrum of the scattered radiation.02-04-2010
20100296085RAMAN SPECTROMETRY ASSEMBLY - A Raman spectrometry assembly includes a Raman spectrometer having a laser light source and a Raman signal analyzer, an interface module comprising a housing which is connectable to and disconnectable from the spectrometer, and a fiber optic assembly which is connectable to and disconnectable from the interface module, the fiber optic assembly including optical fibers and a probe head at a distal end thereof for disposition adjacent a specimen to be tested, the optical fibers extending from the probe head and adapted to extend to the interface module.11-25-2010
20100097603SPECTROSCOPIC APPARATUS AND METHODS04-22-2010
20100079752SPECTROMETER SENSOR COMPRISING MOVING OPTICAL MEANS AND CORRESPONDING SPECTROMETER - A sensor for a spectrometer is provided, which includes at least one optical element onto which an excitation light source beam is directed and from which a target beam is emitted towards a sample to be analyzed. The at least one optical element can move, thereby enabling the direction of the target beam to be varied.04-01-2010
20100079753RAMAN SPECTROMETER HAVING WAVELENGTH-SELECTIVE OPTICAL AMPLIFICATION - An apparatus and method for obtaining Raman spectra that are suitable for continuous real-time monitoring, utilizing the basic technique of Raman spectroscopy in cooperation with wavelength-selective optical amplification are described. The invention improves the detection sensitivity of conventional Raman spectroscopy by orders of magnitude by providing strong wavelength-selective optical amplification and narrowband detection of the intense driving laser and the weak Raman signal(s), thereby essentially eliminating the driving laser signal from the detector and detection electronics. The invention is effective for both Stokes and anti-Stokes Raman lines, and either where the incident laser wavelength is fixed and the Raman spectrum is recorded by analyzing the output of the fiber amplifier with a spectrometer, or where the detection wavelength is fixed and the Raman spectrum is recorded by tuning the wavelength of the laser.04-01-2010
20090168059Analysis method effected with rapid analyte chemical separation and quick detection - A stationary medium is employed both to separate chemicals from a sample solution and also to generate surface-enhanced Raman scattering, so that spectral analysis of the separated analyte chemical can be performed. Applied driving force causes the sample to flow into the stationary medium and to distribute therethrough, thereby causing rapid separation of the analyte chemical, and surface-enhanced Raman scattered radiation is quickly detected, at a plurality of locations along a flow path defined by the stationary medium, for ultimate analysis.07-02-2009
20080304060MICROSTRUCTURES, METHOD FOR PRODUCING MICROSTRUCTURES, AND OPTICAL FIELD AMPLIFYING DEVICE - A microstructure is formed on a conductor. The microstructure is equipped with a dielectric base material, in which a great number of fine holes having substantially the same shape in plan view are formed. The fine holes are open at the surface of the dielectric base material, and are substantially uniformly provided therein. A plurality of micro metal members are fixed to the dielectric base material. The micro metal members include filling portions that fill one or more of the fine holes, and protruding portions that protrude from the surface of the dielectric base material and are of diameters greater than the fine holes, capable of inducing local plasmon. The plurality of micro metal members include those that have different numbers of filling portions.12-11-2008
20090073432APPARATUS AND METHOD FOR RAMAN SPECTROSCOPY AND MICROSCOPY WITH TIME DOMAIN SPECTRAL ANALYSIS - An apparatus and method for measuring Raman-type spectra using optical dispersion to convert an optical spectrum into a waveform which can be detected directly in the time domain without the use of a conventional spectrometer. In the example of stimulated Raman spectroscopy, the apparatus and method exposes a sample to a chirped, pulsed probe beam and a Raman pump beam and the resulting Raman spectra is detected by an optical detector in the time domain, and analyzed. Alternatively, the Raman spectra from the probe and pump beams is chirped with a dispersive element prior to detection and analysis. Each probe pulse provides a snapshot of the Raman spectrum that is sampled in time so that neither repetitive waveforms nor static samples are required. Therefore, high speed acquisitions and high throughput assays can be conducted. To facilitate detection, these spectral signals can also be amplified using distributed Raman amplification directly in the dispersive element.03-19-2009
20100296086INTEGRATED DEVICE CAPABLE OF PERFORMING CHEMICAL SEPARATION AND LIGHT SCATTERING - An integrated chemical separation device includes a single device body, a chemical separation unit configured to separate a chemical from a fluid, a Raman sensor substrate comprising one or more surfaces configured to be adsorbed by molecules of the chemical from the fluid, and a Raman scattering spectrometer unit that can emit a laser beam to illuminate the Raman sensor substrate and to detect the chemical from the light scattered from the Raman sensor substrate. The chemical separation unit, the Raman sensor substrate, and the Raman scattering spectrometer unit are held in or mounted to the single device body.11-25-2010
20080204742Method and System for Optimizing Surface Enhanced Raman Scattering - A substrate for enhanced electromagnetic spectroscopy of an analyte comprises a solid support and a plurality of individual nanoparticles affixed thereto, wherein the nanoparticles are designed to have an increased electromagnetic field strength and/or plasmon resonance frequency that is between the frequency of an incident electromagnetic radiation and the frequency of the Raman response from the analyte and wherein the Raman response is enhanced by the individual nanoparticles. The nanoparticles may comprise a shell surrounding a core and the thicknesses of the core and the shell are selected to produce a plasmon resonance frequency. The wavelength of the incident radiation may be between 200 nm and 20 microns. A method for carrying out spectroscopy comprises providing a light source having a frequency different from that of the analyte, selecting a nanoshell configuration, providing a plurality of nanoshells with that configuration, and affixing the nanoparticles to a support.08-28-2008
20080204743METHOD AND APPARATUS FOR IMPROVED SIGNAL TO NOISE RATIO IN RAMAN SIGNAL DETECTION FOR MEMS BASED SPECTROMETERS - A method of Raman detection for a portable, integrated spectrometer instrument includes directing Raman scattered photons by a sample to an avalanche photodiode (APD), the APD configured to generate an output signal responsive to the intensity of the Raman scattered photons incident thereon. The output signal of the APD is amplified and passed through a discriminator so as to reject at least one or more of amplifier noise and dark noise. A number of discrete output pulses within a set operational range of the discriminator is counted so as to determine a number of photons detected by the APD.08-28-2008
20110164246NEXT GENERATION FLOW CYTOMETER SORTER - The invention relates to a method for sorting particles and a corresponding sorting device, Thereby the particles comprise at least one constituent and the particles are provided by a flow cytometry device. By using coherent anti-Stokes Raman spectroscopy (CARS) certain characteristics of the at least one constituent are detected. A subsequent sorting of the particles bases on the detection results from the CARS.07-07-2011
20120062885body fluid detection method using surface enhanced Raman spectroscopy - This invention provides a body fluid detection method by using surface enhanced Raman spectroscopy. In this method, some biological macromolecules in body fluid samples could be separated with membrane electrophoresis technique firstly. Next, samples are cut off along with the substrates and touched with glacial acetic acid. Transparent colloid formed while incubating. Then add enhancing substrates and continue to incubate and stir. When solid impurities precipitated, stop incubating and stand for layering. In the end, take upper layer resulted to be tested using SERS detection method and build SERS database. This invention successfully eliminated disturbance of other complex components on the SERS detection of protein, DNA and RNA. High quality SERS spectrum obtained is beneficial to the analysis and process of SERS spectrum. Thus body fluid can be differentiated by comparing body fluid SERS spectrum belonging to the healthy people and patients.03-15-2012
20120062881OPTICAL DEVICE UNIT AND DETECTION APPARATUS - An optical device unit includes: an optical device which has an electrical conductor and is capable of enhancing Raman scattering light generated by receiving light from a light source; and a first guide unit which guides a gaseous sample to the optical device. The optical device unit is detachable from the detection apparatus.03-15-2012
20110032521SYSTEM FOR USING HIGH ASPECT RATIO, METAL PARTICLES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) - In accordance with the invention there are systems and methods of preparing surface enhanced Raman spectroscopy substrate and methods of enhanced detection of an analyte.02-10-2011
20100284001SURFACED ENHANCED RAMAN SPECTROSCOPY SUBSTRATES - Manufacturing a surface enhanced Raman spectroscopy (SERS) active structure includes exposing a substrate to produce an exposure pattern then etching the substrate based on the exposure pattern to produce a plurality of nanostructure cores having a plurality of sides extending from the substrate. Adjacent nanostructure cores are separated by core gaps. SERS active material is deposited onto the plurality of nanostructure cores producing a structure having gaps suitable for use in a SERS process.11-11-2010
20100284002THERMAL CONDUCTIVITY MEASUREMENT APPARATUS FOR ONE-DIMENSIONAL MATERIAL AND MEASUREMENT METHOD - A thermal conductivity measurement apparatus for measuring a thermal conductivity of a one-dimensional material includes a substrate, a vacuum chamber receiving the substrate and four spaced electrodes. The one-dimensional material spans across the four spaced electrodes. A middle part of the one-dimensional material, located between the second and third electrodes, is suspended. The present disclosure further provides a method for measuring the thermal conductivity of the one-dimensional material.11-11-2010
20090002702DISTINGUISHING BETWEEN RENAL ONCOCYTOMA AND CHROMOPHOBE RENAL CELL CARCINOMA USING RAMAN MOLECULAR IMAGING - A system and method to provide a diagnosis of the renal disease state of a test renal sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known renal sample and an associated known renal disease state. A test renal sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a renal disease state of the test renal sample is provided. The renal disease state includes renal oncocytoma or chromophobe renal carcinoma disease state.01-01-2009
20120062880OPTICAL FIBER PROBE AND RAMAN DETECTING SYSTEM HAVING SAME - An optical fiber probe includes an optical fiber, a carbon nanotube film structure, and a number of metallic particles. The optical fiber includes a detecting end. The carbon nanotube film structure is located on a surface of the detecting end. The carbon nanotube film structure includes a number of carbon nanotubes joined by van der Waals attractive force therebetween. The metallic particles are located on outer surfaces of the carbon nanotubes.03-15-2012
20110085164METHOD AND APPARATUS FOR AUTOMATED SPECTRAL CALIBRATION - A method and apparatus for automated spectral calibration of a spectroscopy device. A method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum.04-14-2011
20110134421APPARATUS AND METHOD FOR RAMAN SIGNAL DETECTION - Raman band detection apparatus illuminates a sample using an illumination source that oscillates in wavelength over a range. The source might for example switch between two wavelengths or might traverse the wavelength range. A wavelength sensitive detector detects radiation emitted by the sample at a series of different wavelengths and a signal processor extracts signals that have a temporal correspondence to the wavelength variation of the illumination at the different wavelengths. One or more Raman bands that might be present will produce a distinctive characteristic of the extracted signals plotted against a spectral axis and relatively simple processing of these spectrally-related time-varying components can then enhance the appearance of the Raman band in a spectral representation based on the processed components. For example, such processing might comprise numerical integration across a spectral plot of the components, or the selection and shifting of certain components, for instance negative components, to overlie others within portions of the spectral representation showing the presence of the Raman band.06-09-2011
20110134422METHOD FOR DETECTING VIBRATIONAL STRUCTURE OF A MOLECULE AND A SYSTEM THEREOF - The present invention relates to a method for detecting vibrational structure of a molecule by generation of the Loss signals with the help of interaction of White Light Continuum (WL) and narrow spectral width picosecond pulse on the surface of the sample, known as Ultrafast Raman Loss Spectroscopy (URLS). The invention further defines a system for generation of Loss signals for detection of the vibrational structure of a molecule.06-09-2011
20100110426METHOD FOR NRB-FREE NONLINEAR VIBRATIONAL SPECTROSCOPY AND MISCROSCOPY - Methods and systems are described for suppressing nonresonant background in broadband coherent anti-Stokes Raman scattering (CARS) microscopy and spectroscopy. The methods and systems improve sensitivity and signal to noise ratio in CARS.05-06-2010
20100110422OPTICAL DEVICES AND SYSTEMS FOR USE IN SPECTROSCOPY - Certain examples described herein are directed to optical devices and systems for use in spectroscopy. In particular, certain embodiments described herein are directed to devices and methods that may separate excitation light and Raman optical pathways, prior to sample irradiation, so that, if desired, the excitation light and the Raman scattered radiation may be independently manipulated.05-06-2010
20100110425ILLUMINATION OF DIFFUSELY SCATTERING MEDIA - The invention provides a technique for increasing the illumination intensity of probe light in a diffusely scattering sample without increasing the power of the probe beam. Generally, an optical filter is used which permits a collimated probe beam of light to pass through to the sample, but which reflects back towards the sample much of the backscattered scattered probe light emerging at a wider range of angles. In particular embodiments a collimated laser beam is delivered to the sample through a multi-layer dielectric filter covering a portion of the sample. The filter is transmissive to the laser light at normal incidence, but reflective at shallower angles of incidence characteristic of the backscattered light.05-06-2010
20110007308METHOD FOR REMOVAL OF WAX FROM POROUS STONES IN HISTORICAL MONUMENTS - Disclosed embodiments include methods for cleaning wax, substantially equivalent impurities, and other contaminants from porous stones in historical monuments and artworks using nondestructive means. According to one embodiment the method for removal of contaminants from porous stones using laser comprises the following method steps: (a) identifying regions of a contaminant on the porous stone monument; (b) characterizing the contaminant on the porous stone monument; (c) exposing the contaminant on the porous stone monument to irradiation from a laser characterized by a wavelength, a pulse length, a repetition rate, and a laser energy fluence determined and optimized for a given contaminant-porous stone system and the laser characteristics; and (d) adaptively evaluating the cleaning results by quantifying the thickness of the remaining contaminant.01-13-2011
20100214562DEVICE AND METHOD FOR NON-INVASIVELY EVALUATING A TARGET OF INTEREST OF A LIVING SUBJECT - In one aspect, the present invention relates to a probe using integrated confocal reflectance imaging, confocal Raman spectroscopy, and gross spatial imaging for non-invasively evaluating a target of interest of a living subject. In one embodiment, the probe includes a casing with a first end and an opposite, second end, a first optical port, a second optical port, and a third optical port, where the first and second optical ports are located at the first end of the casing and the third optical port is located at the second end of the casing such that the first and third optical ports define a first optical path between them and the second and third optical ports define a second optical path between them, respectively, where each of the first and second optical paths has a first portion and a second portion, where the second portions of the first and second optical paths are substantially overlapped and proximal to the third optical port, and where the probe also includes a collimation lens, a coupling lens, an objective lens assembly, a first mirror, a second mirror, a third mirror, a band pass filter, a long pass filter, a scanning member, an electronic imaging device, and a focus control device, where the collimation lens, the band pass filter, and the second mirror are placed at the first portion of the first optical path, where the coupling lens, the long pass filter, and the first mirror are placed at the first portion of the second optical path, and where the third mirrors, the scanning member, and the objective assembly are placed at the overlapped second portion of the first and second optical paths.08-26-2010
20110261354TIME RESOLVED RAMAN SPECTROSCOPY - System, method, and apparatus for determining the composition of a sample of material. In one embodiment, the method pertains to the counting of photons that were inelastically scattered by the sample, and for minimizing the effects of fluorescent or phosphorescent photons. In yet another embodiment of the invention, a sample is illuminated by a repetitive pulse of monochromatic light, and the resultant scattered photons from the samples are collected and counted during a predetermined integration period. Yet other embodiments pertain to a low-cost, computer-controlled system for repetitively counting inelastically scattered photons so as to create a Raman histogram and a Raman spectrogram of the photons.10-27-2011
20110188034SURFACE ENHANCED RAMAN SPECTROSCOPY EMPLOYING VIBRATING NANORODS - A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.08-04-2011
20110188033MOLECULE DETECTION USING RAMAN LIGHT DETECTION - An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.08-04-2011
20110188035VIBRATING TIP SURFACE ENHANCED RAMAN SPECTROSCOPY - A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector.08-04-2011
20100027001Method and apparatus using volume holographic wavelength blockers - The invention disclosed here teaches methods to fabricate and utilize a non-dispersive holographic wavelength blocker. The invention enables the observation of the Raman signal near the excitation wavelength (˜9 cm02-04-2010
201000203183-Color multiplex cars spectrometer - The present invention relates to a 3-color multiplex CARS spectrometer. In the 3-color multiplex CARS spectrometer, Raman resonance is achieved for multiple molecular vibrations of a sample by the combination of a short-wavelength pump beam generated by a broadband laser light source and a long-wavelength Stokes beam generated by a stable laser light source, and another short-wavelength laser beam having a narrow linewidth is then introduced separately to serve as a probe beam that interacts with the laser-driven sample, thereby generating CARS spectral signals whose wavelength components can be resolved. Accordingly, the 3-color multiplex CARS spectrometer solves problem of the conventional 2-color multiplex CARS spectroscopy in which the wavelength decomposition of CARS signals, necessary for high spectral resolution, is not possible with broadband pump light causing the CARS spectrum distortion.01-28-2010
20100171950METHODS FOR UNIFORM METAL IMPREGNATION INTO A NANOPOROUS MATERIAL - The methods, systems 07-08-2010
20080266557High Contrast Tip-Enhanced Raman Spectroscopy - The present invention relates generally to the field of spectroscopy, and more particularly to tip-enhanced Raman spectroscopy that provides an enhanced contrast-ratio of a near-field Raman signal to a background signal. The near-field Raman signal is captured from a small volume of material near a metal-coated tip thereby achieving submicron lateral resolution.10-30-2008
20100014078RAMAN SPECTROSCOPY - A micro-fluidic system comprising means for optically trapping a particle and a Raman excitation source for causing Raman scatter from the particle whilst it is in the optical trap.01-21-2010
20120307238MICROSCOPE AND OBSERVATION METHOD - Provided is a microscope and an observation method which can improve spatial resolution. A microscope according to an aspect of the invention includes a laser light source (12-06-2012
20110109902TRACE DETECTION DEVICE OF BIOLOGICAL AND CHEMICAL ANALYTES AND DETECTION METHOD APPLYING THE SAME - Disclosed is a trace detection device of a biological and chemical analyte, including a metal substrate, a periodic metal nanostructure on the metallic substrate, a dielectric layer on the periodic metal nanostructure, and a continuous metal film on the dielectric layer. Tuning the thickness of the dielectric layer and/or the continuous metal film to meet the laser wavelength can shift the absorption peak wavelength of the sensor, thereby further enhancing the Raman signals of the analyte molecules.05-12-2011
20120038915APPARATUS FOR RECEIVING RAMAN SCATTERING SIGNALS AND METHOD OF DOING THE SAME - An apparatus for receiving Raman scattering signals, includes an optic light-collection system for collecting Raman scattering lights having scattered from an object when excitation laser beams are irradiated thereto, a spectroscope including a diffraction grating, for separating the Raman scattering lights into its spectral components, and an optical path converter including at least one optical waveguide for converting lights having been collected by the optic light-collection system into slit-shaped lights in compliance with an orientation of the diffraction grating.02-16-2012
20100309465COHERENT ANTI-STOKES RAMAN HOLOGRAPHY - Apparatus and methods of four wave mixing (FWM) holography are described, including illuminating a sample with a first beam, a second beam, and a third beam, and combining the generated FWM signal with a reference beam at a imaging device to obtain holographic image data. In some examples, the first and second beams may be provided by a single pump-probe beam. The third beam may be a Stokes beam or an anti-Stokes beam. A representative example is coherent anti-Stokes Raman holography (CARS holography), which includes illuminating a sample with a pump/probe beam and a Stokes beam to obtain a CARS signal from the sample; and combining the CARS signal with a reference beam to obtain a CARS hologram.12-09-2010
20100053605GAS SAMPLING DEVICE AND METHOD FOR COLLECTION AND IN-SITU SPECTROSCOPIC INTERROGATION OF VAPORS AND AEROSOLS - A gas sampling device, analyte detection system, and methods for identifying a vapor or aerosol analyte suspended in a gas are described. The gas sampling device comprises a chamber having a gas inlet port, a substrate, one or more gas outlet ports near the substrate, and a pump. The gas outlet ports direct airflow to a reflecting substrate coated with a spectroscopically-transparent material. Analytes are deposited on the coated substrate through impaction, for massive aerosols, and diffusion through the viscous boundary layer, for vapor analytes. In one analyte detection system, a spectroscopic instrument is positioned behind a window opposite the substrate to interrogate the coated substrate surface as analytes are collected. An alternate detection system combines the gas sampling device with a detector in fluid communication with the gas outlet ports from the chamber, wherein the substrate is used as an analyte concentrator.03-04-2010
20110063610DESIGN OF LARGE AREA SUBSTRATE FOR SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) USING GLASS-DRAWING TECHNIQUE - A method of making a large area substrate comprises drawing a plurality of tubes to form a plurality of drawn tubes, and cutting the plurality of drawn tubes into cut drawn tubes. Each cut drawn tube has a first end and a second end along the longitudinal direction of the respective cut drawn tube. The cut drawn tubes collectively have a predetermined periodicity. The method of making a large area substrate also comprises forming a metal layer on the first ends of the cut drawn tubes to provide a large area substrate.03-17-2011
20110063613SURFACE-ENHANCED RAMAN SCATTERING SUBSTRATE AND RAMAN DETECTING SYSTEM HAVING THE SAME - A surface-enhanced Raman scattering substrate includes a carbon nanotube film structure and a plurality of metallic particles disposed on the carbon nanotube film structure. The carbon nanotube film structure includes a number of carbon nanotubes joined by van der Waals attractive force therebetween. The carbon nanotube film structure is a free-standing structure.03-17-2011
20110063612RAMAN DETECTING SYSTEM AND DETECTION METHOD FOR USING THE SAME - A Raman detecting system for detecting a vapor of an explosive includes a surface-enhanced Raman scattering substrate for absorbing the vapor of the explosive. The substrate includes a carbon nanotube film structure and a plurality of metallic particles disposed on the carbon nanotube film structure. The carbon nanotube film structure includes a plurality of stacked carbon nanotube films.03-17-2011
20110317158CYTOLOGICAL METHOD FOR ANALYZING A BIOLOGICAL SAMPLE BY RAMAN SPECTROSCOPY - Provided herein are systems and methods that permit low resolution Raman spectroscopy to be used for detection of biological components within cells in order to classify the cells, for example, as premalignant, malignant, or benign.12-29-2011
20110317160BROAD BAND STRUCTURES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY - Broad band structures for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure is made up of a metal layer, and a dielectric layer established on at least a portion of the metal layer. The dielectric layer has a controlled thickness that varies from at least one portion of the dielectric layer to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances.12-29-2011
20110317159Apparatus for effecting analysis with rapid analyte chemical separation and subsequent detection - A stationary medium is employed both to separate chemicals from a sample solution and also to generate surface-enhanced Raman scattering, so that spectral analysis of the separated analyte chemical can be performed. Applied driving force causes the sample to flow into the stationary medium and to distribute therethrough, thereby causing rapid separation of the analyte chemical, and surface-enhanced Raman scattered radiation is quickly detected, at a plurality of locations along a flow path defined by the stationary medium, for ultimate analysis.12-29-2011
20090033928Raman spectrometry assembly - A Raman spectrometry assembly includes a Raman spectrometer having a laser light source and a Raman signal analyzer, an interface module comprising a housing which is connectable to and disconnectable from the spectrometer, and a fiber optic assembly which is connectable to and disconnectable from the interface module, the fiber optic assembly including optical fibers and a probe head at a distal end thereof for disposition adjacent a specimen to be tested, the optical fibers extending from the probe head and adapted to extend to the interface module.02-05-2009
20110080580OPTICAL SIGNAL PROCESSING WITH MODELOCKED LASERS - The invention relates to scanning pulsed laser systems for optical imaging. Coherent dual scanning laser systems (CDSL) are disclosed and some applications thereof. Various alternatives for implementation are illustrated. In at least one embodiment a coherent dual scanning laser system (CDSL) includes two passively modelocked fiber oscillators. In some embodiments an effective CDSL is constructed with only one laser. At least one embodiment includes a coherent scanning laser system (CSL) for generating pulse pairs with a time varying time delay. A CDSL, effective CDSL, or CSL may be arranged in an imaging system for one or more of optical imaging, microscopy, micro-spectroscopy and/or THz imaging.04-07-2011
20120044487OPTICAL BEAM SPECTROMETER WITH MOVABLE LENS - A spectroscopic system is described that provides at least one of focus of an excitation beam onto a sample, automatic focus of an optical system of the spectroscopic system for collecting a spectroscopic signal, and/or averaging of excitation intensity over a surface area of the sample.02-23-2012
20090033930Spectral Imaging of Biofilms - A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching.02-05-2009
20120062886Thermally Stable SERS Taggants - An optically active particle and a method of manufacturing said particles, plus methods of tagging a material of interest with said particles are disclosed. The particle comprises a surface-enhanced spectroscopy (SES) active core and a SES active reporter associated with the SES core wherein the particle produces a measurable and thermally stable SES spectrum upon optical interrogation. As used in the disclosure, thermally stable may be defined as maintaining a measurable SES spectrum after the particle or any material tagged with the particle has been exposed to a temperature substantially higher than room temperature.03-15-2012
20120062884DETECTION APPARATUS - A detection apparatus includes: a first light source group having a plurality of light sources; a switch that switches the plurality of light sources to activate at least one of the light sources, a first optical system that introduces light from the activated light source into an electrical conductor of an optical device; and a detector that detects Raman scattering light from the light scattered or reflected by the electrical conductor. Each of the plurality of light sources of the first light source group is capable of radiating light having different polarization directions.03-15-2012
20120002197Method and Apparatus Using Volume Holographic Wavelength Blockers - The invention disclosed here teaches methods to fabricate and utilize a non-dispersive holographic wavelength blocker. The invention enables the observation of the Raman signal near the excitation wavelength (˜9 cm01-05-2012
20100277723Systems and Methods For Remote Unmanned Raman Spectroscopy - A Raman spectroscopy sensor integrated with an unmanned ground vehicle (UGV) includes a UGV having a robot arm and a camera mounted on the robot arm. A laser and telescope associated with a Raman sensor are mounted on the robot arm in such a way as to point in substantially the same direction in which the camera is pointed. A Raman spectral data acquisition and control module is mounted on the UGV and is configured to receive Raman spectral data from the telescope. A remote base station having a display and a data processing and analysis module is configured to receive data from the data acquisition and control module and to display for an operator images from the camera and information related to the Raman sensor. An autofocus system is preferably employed to automatically control telescope focus and thereby enable the Raman sensor to operate over a wide range, e.g., 0.5 m to 10 m.11-04-2010
20120062882OPTICAL DEVICE UNIT AND DETECTION APPARATUS - An optical device unit includes: an optical device that has an electrical conductor and that is capable of enhancing Raman scattering light generated by receiving light from a light source; and a guide unit that guides a gaseous sample to the optical device. The guide unit has a first fluid path for rotating the gaseous sample in an area facing the optical device.03-15-2012
20120013903NANOWIRE LIGHT CONCENTRATORS FOR PERFORMING RAMAN SPECTROSCOPY - Embodiments of the present invention are directed to systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system (01-19-2012
20120013902MULTI-WAVELENGTH RAMAN LIGHT DETECTION FOR DETECTING A SPECIES - An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.01-19-2012
20100110421DEGREE-OF-DISPERSION DETERMINATION METHOD FOR SINGLE-WALLED CARBON NANOTUBES AND DEGREE-OF-DISPERSION DETERMINATION APPARATUS FOR SINGLE-WALLED CARBON NANOTUBES - Laser light having an energy of 1.9±0.1 eV is projected onto a carbon nanotube-containing substance so that a Raman spectrum is acquired. On the basis of the intensity of a peak at Raman shift 221±5 cm05-06-2010
20120113420ELECTRICALLY DRIVEN DEVICES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY - An electrically driven device (05-10-2012
20120026493GRATING FOR MULTIPLE DISCRETE WAVELENGTHS OF RAMAN SCATTERING - Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.02-02-2012
20120026494COMPACT RAMAN ANALYZER FOR RECORDING DISSOLVED GASES IN LIQUIDS WITH HIGH SENSITIVITY AND SPECTRAL RESOLUTION - A Raman head is provided capable of operating at high surrounding pressures. The Raman head has housing having a first, sealed chamber filled with an incompressible liquid and a second chamber that is open to the surrounding environment. At least one bellows can be used to equalize pressure between the first sealed chamber and the surrounding environment. A planar side of a pair of plano-concave lens is positioned within the first chamber and the concave side of each plano-concave lens is positioned within the second chamber of the Raman head. Light emitted as a result of a laser beam in communication with the pair of plano-concave lens can be analyzed by a Raman analyzer.02-02-2012
20090122309Raman Spectral Analysis of Pathogens - A method of assessing occurrence of a plant pathogen in a sample. The method comprises irradiating the sample and assessing radiation scattered from the sample for radiation that exhibits a Raman scattering characteristic of the pathogen. Detection of scattered radiation that exhibits a Raman shift characteristic of the pathogen is an indication that the pathogen occurs in the sample.05-14-2009
20120154800NANOSTRUCTURES AND LITHOGRAPHIC METHOD FOR PRODUCING HIGHLY SENSITIVE SUBSTRATES FOR SURFACE-ENHANCED SPECTROSCOPY - A method for producing planar extended electrodes with nanoscale spacings that exhibit very large SERS signals, with each nanoscale gap having one well-defined hot spot. The resulting highly sensitive substrate has extended metal electrodes separated by a nanoscale gap. The electrodes act as optical antennas to enhance dramatically the local electromagnetic field for purposes of spectroscopy or nonlinear optics. SERS response is consistent with a very small number of molecules in the hotspot, showing blinking and wandering of Raman lines. Sensitivity is sufficiently high that SERS from physisorbed atmospheric contaminants may be detected after minutes of exposure to ambient conditions.06-21-2012
20110080579Chemical sensor employing resonator-enhanced forbidden-light collection - A chemical sensor that includes, in one example embodiment, a dielectric resonator, wherein a material sample to be characterized is positioned a species to be detected, wherein the species is positioned near a surface of the resonator so that evanescent electromagnetic energy emanating from the surface causes Raman scattering from the species. The resonator is adapted to support modes propagating within the resonator, wherein the modes are adapted to yield the evanescent electromagnetic energy and to couple Raman-scattered electromagnetic energy back into one or more of the modes. In a more specific embodiment, the dielectric cavity represents a stable optical resonator. An input coupling optic couples input electromagnetic energy into the dielectric cavity via photon tunneling across a gap between the input coupling optic and the dielectric cavity. A distance across the gap is approximately one wavelength or larger, wherein the wavelength corresponds to a wavelength of the input electromagnetic energy. An output coupling optic is adapted to couple one or more modes within the dielectric cavity that contain electromagnetic energy corresponding to the Raman-scattered electromagnetic energy, and to provide an output signal in response thereto.04-07-2011
20120105841APPARATUS FOR PERFORMING SERS - An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.05-03-2012
20110090497Multimetallic Nanoshells for Monitoring Chemical Reactions - The invention relates to a multimetallic nanoshell sensor which comprises a core that is less conductive that a first metallic layer and having a catalytically active second metallic layer partially or completely surrounding the first metallic layer. The sensor can be used in any surface enhanced spectroscopic applications.04-21-2011
20110090496DOWNHOLE MONITORING WITH DISTRIBUTED OPTICAL DENSITY, TEMPERATURE AND/OR STRAIN SENSING - Distributed density, temperature and/or strain sensing is utilized for downhole monitoring. A method and system for monitoring a rapidly changing parameter in a well includes: detecting gain-based stimulated Brillouin backscattering due to light transmitted through at least one optical waveguide installed in the well, the Brillouin backscattering being dependent upon temperature and strain experienced by the waveguide in the well. The method can include measuring at least one of temperature and strain in the well, with the measurement being performed separately from the step of detecting Brillouin backscattering.04-21-2011
20120300203FLEXIBLE SERS SUBSTRATES WITH FILTERING CAPABILITIES - A method for the formation of flexible surface enhanced Raman spectroscopy substrates with filtering capabilities. The method produces thin flexible substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink which includes stabilized nanoparticles such as silver, gold or copper nanoparticles. The substrates and nanoparticle ink undergo a thermal treatment for an amount of time sufficient to remove liquid vehicle and a substantial portion of the stabilizer. The thermal treatment provides a fractal aggregate nanoparticle layer on the substrate suitable for Raman spectroscopy. Such flexible SERS substrates may be used to detect trace amounts of analyte in large volume samples.11-29-2012
20120300202AUTONOMOUS LIGHT AMPLIFYING DEVICE FOR SURFACE ENHANCED RAMAN SPECTROSCOPY - An autonomous light amplifying device for surface enhanced Raman spectroscopy includes a dielectric layer, at least one laser cavity defined by at least one light confining mechanism formed in the dielectric layer, at least one nano-antenna established on the dielectric layer in proximity to the at least one laser cavity, and a gain region positioned in the dielectric layer or adjacent to the dielectric layer.11-29-2012
20120300201LARGE-COLLECTION-AREA RAMAN PROBE WITH REDUCED BACKGROUND FLUORESCENCE - A compact Raman analysis system combines a near-infrared (NIR) laser source, a 2D array collecting anti-Stokes Raman spectra, and a probe configured to measure complex solid samples, including pharmaceutical tablets and other large-area targets with reduced background fluorescence at relatively low cost. The system collects spectra from an area of 1-mm or greater, preferably 3-12 mm or more, facilitating the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding,11-29-2012
20120162640SENSOR CHIP, DETECTION DEVICE, AND METHOD OF MANUFACTURING SENSOR CHIP - A sensor chip includes a substrate, a relief structure composed of protruding sections formed so as to be arranged on a surface of the substrate to have a lattice shape and a recessed section between the protruding sections, and fine metal particles arranged along upper ridge lines of the respective protruding sections of the relief structure, the protruding sections being adjacent to each other, having a minute gap with which the surface plasmon resonance occurs. By irradiating the gap between the fine metal particles with a laser beam, the localized surface plasmon resonance occurs more efficiently. As a result, the sensor chip capable of taking out the surface enhanced Raman scattering to thereby detect the substance with high sensitivity can be realized.06-28-2012
20100290043PREPARATION OF METAL COLLOIDS - A method is described for producing a silver colloid solution comprised of highly stable resulting colloids, the method comprising: adding an aqueous solution of a hydroxylamine salt to an aqueous solution of an alkali, and then dispersing into the mixture an aqueous solution of the metal ions, the hydroxylamine salt being selected such that the anion, when combined with the said metal ions, would form a metal salt having a very low solubility in water, wherein the metal ion solution is introduced into the mixture in such a manner that the metal ions are substantially dispersed throughout the mixture within one second. A maturing period, preferably at elevated temperatures, leads to a stable state in which the characteristics of the colloid undergo no further changes, and it is preferred to make and store the colloid in a polystyrene container for greatest stability. The resulting colloids from such method exhibit high light-scattering properties of small particle size and low background fluorescence levels, with a long shelf life, making it particularly suitable for Raman spectroscopy.11-18-2010
20100290042Use of Free-space Coupling Between Laser Assembly, Optical Probe Head Assembly, Spectrometer Assembly and/or Other Optical Elements for Portable Optical Applications Such as Raman Instruments - An apparatus includes: a handheld Raman analyzer that can include: a common platform; a laser assembly mounted on a laser platform, the laser platform supported on the common platform by a first material and a second thermally conductive material wherein the first material is softer than the second material; an optical probe head assembly disposed on the common platform, the optical probe head assembly spaced apart from the laser assembly; a spectrometer assembly disposed on the common platform, the spectrometer assembly spaced apart from the optical probe head assembly; and an analysis apparatus configured to identify a specimen based on a Raman signature received from the spectrometer. The laser assembly can be optically coupled to the optical probe head assembly by at least a first free-space coupling region and the optical probe head assembly optically coupled to the spectrometer assembly by at least a second free-space coupling region.11-18-2010
20100245816Near-field Raman spectroscopy - Near-field Raman imaging is performed by holding a dielectric microsphere (e.g. of polystyrene) on or just above the surface of a sample in a Raman microscope. An illuminating laser beam is focused by the microsphere so as to produce a near-field interaction with the sample. Raman scattered light at shifted wavelengths is collected and analysed. The microsphere may be mounted on a cantilever of an atomic force microscope or other scanning probe microscope, which provides feedback to hold it in position relative to the sample surface. Alternatively, the microsphere may be held on the sample surface by an optical tweezer effect of the illuminating laser beam.09-30-2010
20120127464LIGHT SOURCE APPARATUS - A light source apparatus that emits pulsed light includes an optical resonator and a modulator. The optical resonator has an optical gain medium that amplifies light and an optical waveguide. The modulator modulates an intensity of the light in the optical resonator. The optical resonator with the optical gain medium includes a plurality of optical resonators having different optical path lengths from each other to make a difference between intervals of free spectral ranges in the plurality of optical resonators, to reduce a spectral line width of the pulsed light compared to that of a light source apparatus separately using the plurality of optical resonators as an individual optical resonator, the spectral line width determined by an envelope formed by a sideband wave of an oscillation mode which is generated by the modulation.05-24-2012
20120127465Methods and Apparatus for Transport of Airborne Molecules Using an Active Cyclical Vapor/Liquid Exchange - Methods and apparatus for detection and/or analysis of gas phase analytes and chemical compounds. The apparatus can be formed with microfluidic cells containing a selected fluid that interacts with the analyte(s), wherein the fluid can selectively transition between a vapor phase and a liquid phase. During condensation of the fluid, the population of analytes present within the vapor phase region of the fluid can be transported into the liquid phase region of the fluid within the microfluidic cells. During evaporation of the fluid, the analytes can be substantially retained within liquid phase region of the fluid and within the cells. Repetitive cycling of this vapor/liquid exchange can provide a build-up of the analytes within the microfluidic cells where they can be detected/analyzed.05-24-2012
20120162641METHOD FOR GENERATING AND FOR DETECTING A RAMAN SPECTRUM - A method and a device for generating and for detecting a Raman spectrum enables an automated, or automatable, and at the same time quantitative SERD spectroscopy (for example concentration measurement series). To this end, during the SERD spectroscopy, a first spectrum and a second spectrum are standardized in relation to one another in terms of intensity values and a first difference spectrum is subsequently calculated, a second difference spectrum is calculated, the first difference spectrum is converted into a first transformation spectrum, the second difference spectrum is converted into a second transformation spectrum, and the Raman spectrum is calculated by adding the first transformation spectrum and the second transformation spectrum.06-28-2012
20100208252Matched Pulse Stimulated Raman Scattering - Methods and apparatus for selectively driving the vibrations of normal modes of a target molecule into coherence using stimulated Raman scattering. In concert, many vibrations produce a larger anti-Stokes signal than a single vibration. The same illumination does not drive other molecules to have coherent vibrations, so these molecules produce a weaker signal. Target and confounder molecules can be distinguished by pulses that drive many vibrations coherently, with applications in coherent Raman microspectroscopy.08-19-2010
20120212732APPARATUS FOR PERFORMING SERS - An apparatus for performing surface enhanced Raman spectroscopy includes an optical waveguide, a plurality of flexible nano-structures, wherein the plurality of nano-structures have respective free ends positioned within an evanescent field to be generated by light propagated through the optical waveguide, wherein the plurality of nano-structures are movable from a first position and a second position, wherein in the first position, the free ends of the plurality of nano-structures are substantially spaced from each other and in the second position, the free ends of a plurality of the nano-structures are substantially in contact with each other.08-23-2012
20100067000Raman spectroscopy - It has been discovered that specially structured metallic films containing voids can deliver a hugely enhanced surface enhanced Raman spectroscopy (SERS) effect. By selecting a particular size and geometry for the voids, metallic films can be provided which have an enhanced photon-to-plasmon conversion efficiency for incident radiation of a predetermined wavelength. Controllable surface-enhanced absorption and emission characteristics may thus be provided, which are useful for SERS and potentially also other optical spectrometry and filtering applications. With such a large Raman signal, the invention enables fast, compact and inexpensive Raman spectrometers to be provided opening up many new application possibilities.03-18-2010
20120212736CRYSTAL FIBER, RAMAN SPECTROMETER USING THE SAME AND DETECTION METHOD THEREOF - The invention relates to a crystal fiber, a Raman spectrometer using the same and a inspection method thereof. The crystal fiber comprises a sapphire crystal is doped with two transition metals having different concentrations. An excitation light beam at a specific wavelength can propagate along the crystal fiber to generate a narrow-band light beam and a wide-band light beam to project on a specimen. Raman scattered light is emitted from the specimen. The wavelength of the Raman scattered light falls within the wavelength range of the wide-band light beam so that the wide-band light beam is enhanced at some characteristic wavelengths to facilitate Raman spectroscopy.08-23-2012
20120212734Compact, Low Cost Raman Monitor For Single Substances - Apparatus for performing Raman analysis may include a laser source module, a beam delivery and signal collection module, a spectrum analysis module, and a digital signal processing module. The laser source module delivers a laser beam to the beam delivery and signal collection module. The beam delivery and signal collection module delivers the laser source beam to a sample, collects Raman scattered light scattered from the sample, and delivers the collected Raman scattered light to the spectrum analysis module. The spectrum analysis module demultiplexes the Raman scattered light into discrete Raman bands of interest, detects the presence of signal energy in each of the Raman bands, and produces a digital signal that is representative of the signal energy present in each of the Raman bands. The digital signal processing module is adapted to perform a Raman analysis of the sample.08-23-2012
20120212733TAILORED RAMAN SPECTROCOPIC PROBES FOR ULTRASENSITIVE AND HIGHLY MULTIPLEXED ASSAYS - Embodiments of nanostructured, multilayered metal-dielectric particles suitable for use as Raman spectroscopic probes are disclosed, as well as methods of designing, making and using such multilayered nanoparticles, and kits including the multilayered nanoparticles. The multilayered nanoparticles include alternating metal and dielectric layers and an outer dielectric shell. One or more of the dielectric layers may include a plurality of reporter molecules. Embodiments of the multilayered nanoparticles are suitable for detecting target analytes in a sample. Some embodiments of the multilayered nanoparticles are suitable for use in multiplexed assays, including assays for multiple target analytes having differing concentrations.08-23-2012
20120212735System and Method for Detection of Analytes in Exhaled Breath - A sensor for detecting a drug substance (08-23-2012
20120133932METHODS FOR EMPLOYING STROBOSCOPIC SIGNAL AMPLIFICATION AND SURFACE ENHANCED RAMAN SPECTROSCOPY FOR ENHANCED TRACE CHEMICAL DETECTION - In one embodiment, a method and system is provided for detecting target materials using a combination of stroboscopic signal amplification and Raman spectroscopy techniques.05-31-2012
20120133933METHOD FOR REDUCING LOSS OF ELECTROMAGNETIC RADIATION IN DETECTION APPLICATIONS - The application provides a method for reducing the loss of electromagnetic radiation caused by passing electromagnetic radiation through material with a rough surface. The method comprises applying a surface layer, such as a liquid or plastic film, to the material. The surface layer masks or decreases the surface irregularities or effects therefrom resulting in decreased loss of electromagnetic energy.05-31-2012
20120170034SPECTROSCOPY USING NANOPORE CAVITIES - A system for assisting in spectrally characterizing or detecting a sample using radiation at a predetermined wavelength or in a predetermined wavelength range is disclosed. In one aspect, the system includes a substrate having a nanopore for excitation of plasmons. The nanopore provides a window through the substrate, wherein a smallest window opening of the window has an average length (L) and an average width (W) both being substantially smaller than 2 μm. The nanopore supports highly confined surface plasmon polaritons and at specific wavelengths resonances are observed, when the conditions for a standing wave are fulfilled. This leads to strong field enhancements and enables single molecule spectroscopy.07-05-2012
20120170033METHOD FOR DETECTING SINGLE MOLECULE - A method for detecting single molecule includes providing a carrier. The carrier includes a substrate and a metal layer. The substrate has a surface and defines a number of blind holes caved in the substrate from the surface thereof. The metal layer covers the surface of the substrate and inner surfaces of the number of blind holes. Single molecule samples are disposed on the metal layer. The single molecule samples are detected by a Raman Spectroscopy system.07-05-2012
20120170032CARRIER FOR SINGLE MOLECULE DETECTION - A carrier for single molecule detection includes a substrate and a metal layer. The substrate has a surface and includes a number of three-dimensional nano-structures at the surface. The metal layer is located on the surface of the substrate and covers the three-dimensional nano-structures. The enhancement factor of SERS of the carrier is relatively high.07-05-2012
20100053606RAMAN DETECTION OF CONTAINER CONTENTS - Methods and apparatus for screening the unknown contents of containers using Raman spectroscopy are disclosed, especially for security screening applications such as in airports. A probe light beam is directed through the wall of a container to a sample region within the container contents. Light scattered out of the beam within the sample region is collected along a path which passes through a separate part of the container wall, for Raman spectral analysis.03-04-2010
20120257198DETECTION DEVICE - A detection device includes an optical device, a suction section adapted to suck the fluid sample in the optical device, a light source adapted to irradiate the optical device with light, a light detection section adapted to detect light emitted from the optical device, and a control section adapted to perform drive control on the suction section. The optical device emits light reflecting the fluid sample to be adsorbed. The control section sets a suction flow velocity of the fluid sample on the optical device to V10-11-2012
20120176613FIBER OPTIC PROBES UTILIZING GRIN LENSES FOR SPATIALLY PRECISE OPTICAL SPECTROSCOPY - The invention provides improved fiber optic probe assemblies which utilize a configuration of gradient index (GRIN) lenses to deliver light to a focal point and collect light for analysis from the same focal point. Also provided are methods for manufacturing the probe assemblies and related methods of spatially precise spectroscopy using the probe assemblies.07-12-2012
20120236304SERS-ACTIVE ABSORBERS FOR THE ANALYSIS OF ANALYTES - Solid-type SERS-active substrates (e.g., noble metallic nanostructured powders or noble metallic nanoparticle-coatings on beads, microbeads, particles, etc.) are contained within optically-transparent modules. The modules allow for the controlled introduction of analyte-bearing fluid(s) into SERS-active substrates. The modules also allow for the monitoring of SERS signals emanating from analyte(s) which have accumulated on the confined SERS-active substrates. These SERS signals may be monitored over time by direct readout of the SERS substrates through the optically transparent module for chemical analysis and chemical detection applications.09-20-2012
20120257197FOURIER DOMAIN SENSING - Methods and systems are disclosed of sensing an object. A first radiation is spatially modulated to generate a structured second radiation. The object is illuminated with the structured second radiation such that the object produces a third radiation in response. Apart from any spatially dependent delay, a time variation of the third radiation is spatially independent. With a single-element detector, a portion of the third radiation is detected from locations on the object simultaneously. At least one characteristic of a sinusoidal spatial Fourier-transform component of the object is estimated from a time-varying signal from the detected portion of the third radiation.10-11-2012
20120257199METHOD OF DIAGNOSING MALARIA INFECTION IN A PATIENT BY SURFACE ENHANCED RESONANCE RAMAN SPECTROSCOPY - Present disclosure relates to a method of diagnosing malaria infection in a patient by Surface Enhanced Raman Spectroscopy (SERS). The method includes obtaining a sample from said patient, mixing the sample with a suspension of magnetic nanoparticles, wherein said magnetic nanoparticles adsorb hemozoin present in the sample onto their surface, obtaining the SERS spectra of the sample, and correlating the obtained SERS spectra to the presence or amount of hemozoin in the sample, wherein the presence of hemozoin is indicative of malaria infection.10-11-2012
20120188540RECONFIGURABLE SURFACE ENHANCED RAMAN SPECTROSCOPY APPARATUS, SYSTEM AND METHOD - A reconfigurable surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a stimulus responsive material to move nanorods of a plurality between inactive and active configurations. The apparatus includes the plurality of nanorods and the stimulus responsive material. The system further includes a Raman signal detector. The method of reconfigurable SERS includes providing the plurality of nanorods and exposing the stimulus responsive material to a stimulus. The exposure causes a change in one or more of a size, a shape and a volume of the stimulus responsive material that moves the nanorods between the inactive and active configurations. The active configuration facilitates one or both of production and detection of a Raman scattering signal emitted by the analyte.07-26-2012
20120188539NANOROD SURFACE ENHANCED RAMAN SPECTROSCOPY APPARATUS, SYSTEM AND METHOD - A nanorod surface enhanced Raman spectroscopy (SERS) apparatus, system and method of SERS using nanorods that are activated with a key. The nanorod SERS apparatus includes a plurality of nanorods, an activator to move the nanorods from an inactive to an active configuration and the key to trigger the activator. The nanorod SERS system further includes a Raman signal detector and an illumination source. The method of SERS using nanorods includes activating a plurality of nanorods with the key, illuminating the activated plurality of nanorods, and detecting a Raman scattering signal when the nanorods are in the active configuration.07-26-2012
20120188538COMMON DETECTOR FOR COMBINED RAMAN SPECTROSCOPY-OPTICAL COHERENCE TOMOGRAPHY - In one aspect of the present invention, an apparatus includes a first light source for generating a broadband light, and a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting the received broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, and a sample arm optically coupled to the beamsplitter and the second light source for combining the sample light and the monochromatic light, delivering the combined sample and monochromatic light to the target of interest, collecting a backscattering light and a Raman scattering light that are generated from interaction of the sample light and the monochromatic light with the target of interest, respectively, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path, and a single detector optically coupled to the beamsplitter for collecting the interference signal.07-26-2012
20120081703Highly Efficient Plamonic Devices, Molecule Detection Systems, and Methods of Making the Same - A plasmonic device has a plurality of nanostructures extending from a substrate. Each of the plurality of nanostructures preferably includes a core, a coating of intermediate material covering at least a portion of the core, and a coating of a plasmonic material. Devices are preferably manufactured using lithography to create the cores, and Plasma Enhanced Chemical Vapor Deposition (PECVD) to deposit the intermediate and/or plasmonic materials. Cores can be arranged in any suitable pattern, including one-dimensional or two-dimensional patterns. Devices can be used in airborne analyte detectors, in handheld roadside controlled substance detectors, in genome sequencing device, and in refraction detectors.04-05-2012
20110122406PROCESSES FOR RAPID MICROFABRICATION USING THERMOPLASTICS AND DEVICES THEREOF - A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.05-26-2011
20110122405GUIDED MODE RESONATOR BASED RAMAN ENHANCEMENT APPARATUS - A system for performing Raman spectroscopy comprises a waveguide layer configured with at least one array of features, the at least one array of features being configured to provide guided-mode resonance for at least one wavelength of electromagnetic radiation; and at least one fluid channel disposed in the waveguide layer. An analyte sensor comprises an electromagnetic radiation source configured to emit a range of wavelengths of electromagnetic radiation, the system for performing Raman spectroscopy, and at least one photodetector configured to detect Raman scattered light.05-26-2011
20100328658Hollow-Core Photonic Crystal Fibre - A hollow core photonic crystal fibre (HCPCF) having a wavelength of operation, the HCPCF comprising: a core region having a first refractive index; a cladding region surrounding the core region and comprising a plurality of microcapillaries arranged in a transverse structure having a pitch, the pitch of the structure being at least five times larger than the wavelength of operation, the cladding region having a second refractive index higher than the first refractive index.12-30-2010
20100328657Enhanced Spectroscopic Techniques Using Spatial Beam Shaping - A Raman spectrometer comprising means for illuminating a sample with a shaped laser beam and a detector that is operable to detect light that is reflected from or transmitted through a sample. Preferably, the shaped laser beam has a dark spot at its centre.12-30-2010
20080297789Raman Spectral Analysis of Pathogens - A method of ablating a viable biological pathogen in a sample. A viable biological pathogen in a portion of the sample is identified by irradiating the sample; assessing radiation scattered from the sample for radiation that exhibits a Raman shift characteristic of the viable biological pathogen, and delivering an ablating agent to the identified portion.12-04-2008
20120327408INTEGRATED DEVICE CAPABLE OF PERFORMING CHEMICAL SEPARATION AND LIGHT SCATTERING - An integrated chemical separation device includes a chemical separation unit configured to separate a plurality of substances in a sample solution, a mixing chamber configured to receive the plurality of substances in the sample solution at different times, a chemical separation and detection controller, and a multi-channel valve configured to direct the plurality of substances in the sample solution to the mixing chamber under the control of the chemical separation and detection controller. The chemical separation and detection controller can introduce nano particles in the mixing chambers to allow each of the plurality of substances to be adsorbed on the nano particles. A Raman scattering spectrometer unit emits a laser beam to illuminate molecules adsorbed on the surfaces of the nano particles and obtains Raman spectra from the plurality of substances.12-27-2012
20120327407Independent Component Analysis of Surface-Enhanced Raman Scattering (SERS) Signals - Embodiments of the present disclosure, in one aspect, relate to methods of analyzing SERS signals, systems for analyzing SERS signals, in particular, using an independent component analysis, and the like.12-27-2012
20120268737System and Device for Non-Destructive Raman Analysis - An improved Raman microspectrometer system extends the optical reach and analysis range of an existing Raman microspectrometer to allow analysis and/or repair of an oversized sample. The improved Raman microspectrometer system includes an extender for extending the optical reach of the existing microspectrometer and a supplemental stage which extends the analysis range of the existing microspectrometer by providing travel capabilities for non-destructive analysis of an entire oversized sample. Such an arrangement decreases manufacturing costs associated with testing oversized samples such as mammography panels, enabling analysis and/or repair to be performed without destruction.10-25-2012
20120268736CONFIGURABLE GRATING BASED ON COLLAPSING NANO-FINGERS - A configurable grating based on collapsing nano-fingers includes a substrate; and a plurality of bendable nano-fingers supported on the substrate. The nano-fingers may be formed in a regular first array and the nano-fingers may be formed in a spacing that, upon closing at their tops, forms a second array to act as an optical grating or a diagnostic tool. A method of fabricating a configurable optical grating based on collapsing nano-fingers is also disclosed, as well as a method of determining an open or closed state for a plurality of nano-fingers.10-25-2012
20100245817Microsphere Having Hot Spots and Method for Identifying Chemicals Through Surface Enhanced Raman Scattering Using the Same - The present invention relates to the microsphere whose surface is covered with hot spots and the method for identifying chemicals through Surface Enhanced Raman Scattering (SERS) using the same. The microsphere having hot spots, according to the present invention, includes a microsphere and metal networks as a shell which covers the surface of the microsphere, and nano-sized pores are distributed randomly on the surface or in the interstitial space of the metal networks. The microsphere having hot spots, according to the present invention, can be individually manipulated under a conventional optical microscope. SERS spectra of the monolayer of molecules on Pt or Au can be measured using single microsphere having hot spots mentioned as a sensitive probe. The microsphere having hot spots can be applied for decoding the microspheres with Raman tags flowing in a microfluidic system.09-30-2010
20110235032Chiral Plasmonic Structures For Mediating Chemical Transformation And Detection Of Molecules With Spatial Chirality - Three-dimensional metal dielectric structures are disclosed with chiral symmetry that elicit surface plasmons. The plasmons may have propagational circular polarization wherein the frequency of such propagating plasmons may be tuned by design to couple with the electronic transitions or fundamental vibrations, including phonons, of a molecular species. The plasmon-molecule coupling, combined with the propagational polarization afforded by the chiral structure may be further exploited to mediate the chemical transformations involving molecules with spatial chirality and/or to detect molecules with spatial chirality.09-29-2011
20120086939Detecting Small Amounts of Substances - In determining whether an object contains e.g. a hazardous substance or molecules of a hazardous substance the object is illuminated with light of a definite wavelength. A telescope collects and concentrates light scattered by the object and a plurality of individual picture elements in a picture element array in a camera receives and detects the collected and concentrated light. The detection signals from each of the individual picture elements are individually analyzed to produce a Raman-spectrum or some similar spectrum valid for the subarea of the illuminated area of the object that corresponds to the respective picture element. The subarea of the illuminated area that corresponds to one of the individual picture elements can be chosen to have a width or dimension chosen to correspond to the size or a dimension of a particle or a molecule of the hazardous substance. A filter that can be tunable can be used for filtering the collected and concentrated light before being received by the camera, so that at each instance light of only one wavelength range is detected.04-12-2012
20120092664OPAQUE ADDITIVE TO BLOCK STRAY LIGHT IN TEFLON.RTM. AF LIGHT-GUIDING FLOWCELLS - The present invention is directed to the use of a light absorbing wall material to eliminate stray light paths in light-guiding structures, such as those used for HPLC absorbance detection. More specifically, the present invention relates to the use of carbon-doped Teflon® AF, or “black Teflon® AF,” for all or part of the walls of a light-guiding flowcell adapted for use in HPLC absorbance detection.04-19-2012
20120092663TRANSMISSION RAMAN SPECTROSCOPY ANALYSIS OF SEED COMPOSITION - The disclosure provides instrumentation for the Raman spectroscopy analysis of seeds or grains, which can be used to determine the composition of the seed, such as its protein and oil content. In some examples the instrumentation includes an illumination device that emits light in the near infrared range, a sample holder to hold the seeds, and a collection device (e.g., Raman spectrograph) that captures the lights emitted by the seeds. Methods of determining the composition of seeds, such as soybeans, using Raman spectroscopy, are also provided.04-19-2012
20120092662COHERENT ANTI-STOKES RAMAN SPECTROSCOPY - A coherent anti-Stokes Raman spectroscopy (CARS) system comprises a laser light source for emitting pulsed light, a dichroic beam splitter for splitting a light pulse from the light source into a pump pulse and a Stokes pulse and directing these pulses along respective distinct paths, chirping means, e.g. dispersive glass blocks for chirping the pump and Stokes pulses, directing means for directing the chirped pump and Stokes samples to a sample in time overlap, and detecting means for detecting light stimulated from the sample by the interaction of the pump and Stokes pulses. The system may comprise a reflector connected to a linear motor, for adjusting the period between the arrival at the sample of the starts of the chirped pump and Stokes pulses. The system may further comprise a pulse replicating unit for converting a pulse from the light source into a plurality of pulses distributed in time.04-19-2012
20120092660APPARATUS FOR PERFORMING SERS - An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.04-19-2012
20120287427SERS SUBSTRATES - A surface-enhanced Raman spectroscopy substrate device, including a base substrate, a single or multiple layered nanostructure that contains metals, and a plasma coating. The nanostructure metal is selected from the group including silver, gold, platinum, copper, titanium, chromium, and combinations thereof. The plasma coating has a thickness of 1-200 nm and may locate on the nanostructure layer or on the base substrate. The plasma coating can precisely control the surface characteristics, including surface energy, hydrophilicity, and contact angle, of the SERS device and may then help to regulate the SERS substrate with well defined and uniform water/oil contact angle with small standard deviation. The water contact angle of the SERS substrate may range from 20 to 140 degrees.11-15-2012
20100177306SERS Nanotag Assays - A method of producing a surface enhanced Raman scattering spectrum which is useful for certain types of assays, in particular proximity assays. The method includes providing two SERS-active nanoparticles. The first SERS-active nanoparticle will absorb a photon at a first wavelength and emit a Raman-shifted photon at a second wavelength. The second SERS-active nanoparticle will absorb a photon at the second wavelength and emit a Raman-shifted photon at a third wavelength. Accordingly, when the first and second SERS-active nanoparticles are proximate to one another and the first SERS-active nanoparticle is illuminated at the first wavelength a Raman-shifted photon at the second wavelength may be emitted. This photon can be absorbed by the second SERS-active nanoparticle causing detectable emission of a second Raman-shifted photon at the third wavelength. Various assays may be designed based upon the above. Proximity assays using two SERS-active nanoparticles will have advantageous background signal characteristics.07-15-2010
20120140217OPTICAL MICROSCOPE AND OPTICAL INSTRUMENTATION - The invention provides an optical microscope that prevents an increase in the complexity of the light source system and is equipped with optics readily capable of adequate operation even when the modulation frequency is increased in order to reduce the impact of the intensity noise of the laser, etc. This optical microscope 06-07-2012
20120140216METHOD FOR EVALUATION OF OXIDE SEMICONDUCTOR ELECTRODE, APPARATUS FOR EVALUATION OF OXIDE SEMICONDUCTOR ELECTRODE, AND APPARATUS FOR PRODUCTION OF OXIDE SEMICONDUCTOR ELECTRODE - Disclosed herein is a method for evaluation of an oxide semiconductor electrode, the method comprising: performing Raman spectrometry on a porous oxide semiconductor layer having a dye adsorbed thereto, thereby acquiring a Raman spectrum having a peak attributable to the dye and a peak attributable to the oxide semiconductor; obtaining from the Raman spectrum a parameter for dye adsorption quantity which is defined by the formula: Parameter for dye adsorption quantity=(Peak intensity attributable to dye)/(Peak intensity attributable to oxide semiconductor); and estimating the amount of the dye adsorbed to the porous oxide semiconductor layer on the basis of the thus obtained parameter for dye adsorption quantity.06-07-2012
20120140215RETRO-REFLECTOR MICROARRAY AND APPLICATION THEREOF - The present invention relates to a retro-reflector microarray including a plurality of micro retro-reflectors arranged on a common plane. Each of the retro-reflectors is a concave corner cube consisting of three mutually orthogonal reflective surfaces. The concave corner cubes are the main reflecting elements of the microarray and make the reflected light anti-parallel to the incident light. The retro-reflector microarray can be used in optical detection instrument as an auxiliary element for remotely scanning fluorescence and Raman signals.06-07-2012
20130021606METHOD FOR DETECTING A RESONANT NONLINEAR OPTICAL SIGNAL AND DEVICE FOR IMPLEMENTING SAID METHOD - The invention relates to a method and a device (01-24-2013
20120242987SURFACE-ENHANCED RAMAN SCATTERING APPARATUS AND METHODS - An apparatus for performing surface-enhanced Raman scattering (SERS) is disclosed wherein an inner surface of a container is coated with SERS active materials such as nanoparticles of noble metals. Such a container can provide a partially enclosed, optical diffuse cavity whose inner surfaces serve for dual purposes of enhancing Raman scattering of the contained analyte and optical integration, therefore improving the efficiency of optical excitation and signal collection. The container may be configured to isolate the SERS active material from the external environment. The container, which may be a cylindrical tube, may be referred to as a SERS tube. Methods of coating the inner wall of a container with pulsed laser ablation and with nanoparticle colloids, respectively, are disclosed.09-27-2012
20100091276APPARATUS FOR DEPTH-SELECTIVE RAMAN SPECTROSCOPY - Apparatus and methods for detecting Raman spectral features non destructively from sub-surface regions of a diffusely scattering sample are disclosed. Incident radiation is supplied at one or more sample surface entry regions, and light is collected from one or more collection regions spaced from the entry regions. Raman features are detected in the collected light, and depth information is derived according to the entry-collection spacings.04-15-2010
20080225288Imaging Systems and Methods - Imaging systems and methods are provided. In one embodiment, an image system is disclosed that comprises a Raman gain medium configured to receive an image from a target area and a tunable laser configured to pump light into the Raman gain medium over a plurality of first wavelengths to induce amplification of the image over a plurality of second wavelengths strokes shifted from the plurality of first wavelengths. The image system further comprises an image detector system that receives and processes the amplified image over the plurality of second wavelengths.09-18-2008
20080225287ANALYTE DETECTION USING NANOWIRES PRODUCED BY ON-WIRE LITHOGRAPHY - The present invention relates to methods of detecting analytes using nanowires having nanodisk arrays. In particular, the present invention discloses methods of detecting analytes via surface enhanced Raman scattering (SERS) and employing nanowires prepared using on-wire lithography (OWL).09-18-2008
20130169959ZERO ORDER SENSING TO INCREASE LIGHT COLLECTION IN A SPECTROMETER - A system for increasing light collection in a spectrometer includes a detector and a processor. The detector detects zero order diffraction light from a diffractive element of a spectrometer and measures an intensity of the zero order diffraction light. A processor continuously receives the intensity measurement from the detector and automatically adjusts a parameter of the spectrometer until a maximum intensity measurement is received from the detector. A parameter of the spectrometer can include an optical path between an aperture of the spectrometer and a sample, an exposure time of the spectrometer, or an intensity of a light source for the spectrometer. The optical path between an aperture of the spectrometer and a sample can be adjusted by moving an objective lens of the spectrometer with respect to the sample or moving the sample with respect to the spectrometer.07-04-2013
20130176562METHOD AND APPARATUS FOR MEASURING CONCENTRATION OF BIOGENIC SUBSTANCE - A method for measuring a concentration of a biogenic substance in a living body includes steps of: preparing an apparatus including a light source, a substrate which has periodic metal structures and generates surface enhanced Raman scattering light by being irradiated with light from the light source, and spectroscopic means which disperses and detects the light, wherein the periodic metal structure is arranged with first and second distances in first and second direction respectively, the first distance is set to generate surface plasmon by matching a phase of the light from the light source, and the second distance is smaller than the first distance and is set between 300 nm and 350 nm; irradiating the substrate with the light from the light source to generate the surface enhanced Raman scattering; detecting the scattering with the spectroscopic means; and calculating the concentration of the biogenic substance based on the scattering.07-11-2013
20120250013NON-LINEAR RAMAN SPECTROSCOPY APPARATUS, NON-LINEAR RAMAN SPECTROSCOPY SYSTEM, AND NON-LINEAR RAMAN SPECTROSCOPY METHOD - A non-linear Raman spectroscopy apparatus includes a light source unit emitting a pulse beam having a pulse width of 0.2 ns to 10 ns, a pulse peak power of 50 W to 5000 W, and a wavelength of 500 nm to 1200 nm, and a single-mode fiber through which continuous white light is generated from the pulse beam. A test sample to be measured is radiated with a pump-cum-probe beam formed of the pulse beam and a Stokes beam formed of the continuous white light to obtain a Raman spectrum.10-04-2012
20130094021METHOD OF FABRICATING GOLD NANOSTRUCTURES USING ELECTROLESS DISPLACEMENT PLATING - The present invention provides a method of fabricating gold nanoparticles using electroless displacement plating, the method including the steps of: depositing on a substrate a metal having a reduction potential lower than that of gold to form a metal layer; and reacting a gold ion-containing plating solution with the metal layer. The invention also provides gold nanoparticles fabricated by the method. According to the method, gold nanostructures can be fabricated in a simple, cost-effective and efficient manner, and the fabricated gold nanoparticles can be used to measure surface-enhanced Raman scattering (SERS) signal or fluorescence. In addition, the invention enables the development of an optical sensor including the gold nanostructures.04-18-2013
20130094020PROBE HAVING NANO-FINGERS - A probe for use in a sensing application includes an elongate body having a first end and a free end, wherein the first end is to be attached to a support. The probe also includes a plurality of nano-fingers having respective bases and tips, wherein each of the plurality of nano-fingers is attached to the free end and is composed of a flexible material, and wherein the plurality of nano-fingers are collapsed toward each other such that the tips of the plurality of nano-fingers are substantially in contact with each other.04-18-2013
20110267613OPTICAL DEVICE, ANALYZING APPARATUS AND SPECTROSCOPIC METHOD - An optical device includes a first projection group in which electrically conductive projections are arranged at a first period along a direction parallel to a virtual plane. When light traveling in a direction inclined with respect to a vertical line directed to the virtual plane is incident on the first projection group, surface plasmon resonance is generated at a first resonance peak wavelength and a second resonance peak wavelength. A first resonance peak wavelength band including the first resonance peak wavelength includes an excitation wavelength in surface-enhanced Raman scattering. A second resonance peak wavelength band including the second resonance peak wavelength includes a Raman scattering wavelength in the surface-enhanced Raman scattering.11-03-2011
20110267611SCATTERING SPECTROSCOPY APPARATUS AND METHOD EMPLOYING A GUIDED MODE RESONANCE (GMR) GRATING - A scattering spectroscopy apparatus, system and method employ guided mode resonance (GMR) and a GMR grating. The apparatus includes a GMR grating having a subwavelength grating, and an optical detector configured to receive a portion of a scattered signal produced by an interaction between an excitation signal and an analyte associated with a surface of the GMR grating. A propagation direction of the received portion of the scattered signal is substantially different from a propagation direction of a GMR-coupled portion of the excitation signal within the GMR grating. The system includes the apparatus and an optical source. The method includes exciting a GMR in a GMR grating, interacting a GMR-coupled portion of the excitation signal with an analyte to produce a scattered signal and detecting a portion of the scattered signal.11-03-2011
20110267610COMPACT SENSOR SYSTEM - A compact sensor system comprising: an analysis cell configured for photon-matter interaction, where photons are received from a light source; and an integrated-optical spectral analyzer configured for identifying a set of frequencies, the integrated-optical spectral analyzer comprising: a waveguide coupled with the analysis cell, the waveguide configured for propagating a set of frequencies through the waveguide; one or more ring resonators coupled with the waveguide, the one or more ring resonators comprising a predetermined bandwidth and configured for capturing the set of frequencies corresponding to frequencies within the predetermined bandwidth; and one or more frequency detectors coupled with the one or more tunable ring resonators, the one or more frequency detectors configured for generating electrical signals that identify each of the set of frequencies.11-03-2011
20110267609APPARATUS FOR PERFORMING SERS - An apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a reflective layer positioned above the substrate, a plurality of tapered nanowires disposed above the reflective layer, each of the plurality of tapered nanowires having a tapered end directed away from the reflective layer.11-03-2011
20110267607ENHANCING SIGNALS IN SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) - An integrated device for enhancing signals in Surface Enhanced Raman Spectroscopy (SERS). The integrated device comprising an array of nanostructures comprising a material, wherein the material is configured to allow light to pass through. The integrated device also comprising SERS active nanoparticles disposed on at least portion of the array of nanostructures and a mirror integrated below a base of the array of nanostructures. The mirror is configured to reflect light passing through the material into the array of nanostructures.11-03-2011
20110267606SURFACE-ENHANCED RAMAN SPECTROSCOPY DEVICE AND A MOLD FOR CREATING AND A METHOD FOR MAKING THE SAME - A surface-enhanced Raman spectroscopy device includes a substrate, and an ultraviolet cured resist disposed on the substrate. The ultraviolet cured resist has a pattern of cone-shaped protrusions, where each cone-shaped protrusion has a tip with a radius of curvature equal to or less than 10 nm. The ultraviolet cured resist is formed of a predetermined ratio of a photoinitiator, a cross-linking agent, and a siloxane based backbone chain. A Raman signal-enhancing material is disposed on each of the cone-shaped protrusions.11-03-2011
20130169960Surface Enhanced Raman Spectroscopy on Optical Resonator (e.g., Photonic Crystal) Surfaces - Highly sensitive Surface Enhanced Raman Spectroscopy (SERS) sensors are described in the form of a optical resonator and a metal nanostructure deposited on surface of the optical resonator. In one embodiment the optical resonator is in the form of a photonic crystal, but other optical resonators are contemplated. Examples are described in which the resonant near-fields of a large-area replica molded photonic crystal efficiently couples light from a laser to dielectric-metal “post-cap” nanostructures deposited on the photonic crystal surface by a glancing angle evaporation technique, achieving a high SERS enhancement factor. Other constructions are also contemplated a metal nanostructure formed on a dielectric support deposited on the photonic crystal, including a metallic film deposited over close-packed surface of nanospheres, arrays of metallic nanotriangles, metallic nanorods, metallic nanohelices, arrays of metallic nanospheres, and roughened metal surfaces.07-04-2013
20130128265THIN LAYER CHROMATOGRAPHY-SURFACED ENHANCED RAMAN SPECTROSCOPY CHIPS AND METHODS OF USE - The present disclosure includes methods of simultaneous analyte separation and detection using surface enhanced Raman spectroscopy (SERS)-active ultra thin layer chromatography (UTLC) chips. The SERS-active UTLC chips of the present disclosure are used to physically separate compounds within a mixture, which are then identified based on their unique SERS spectra.05-23-2013
20130141719METAL PARTICLES FOR SURFACE-ENHANCED RAMAN SCATTERING AND MOLECULAR SENSING - There is provided a high-sensitive Raman scattering sensing by regulating in metal nanoparticles for enhanced Raman scattering, particularly the strength of the enhanced electric field by controlling the distance between the particles to impart very strong Raman scattering properties. A metal nanoparticle material for molecular sensing, the metal nanoparticle material comprising: a metal nanoparticle aggregate including three to ten metal nanoparticles connected to each other through an organic molecule so that adjacent metal nanoparticles are bonded and spaced apart a predetermined distance, the aggregate containing a Raman active molecule within a field applied to the aggregate, wherein the metal nanoparticle material emits enhanced Raman scattering light from the Raman active molecule in an enhanced electric field; a method for producing the metal nanoparticle material for molecular sensing; and a molecular sensing by use of the metal nanoparticle material for molecular sensing.06-06-2013
20110216313SUPERVISED PRINCIPAL COMPONENT ANALYSIS - The invention provides a multivariate modeling method for quantitative analysis by supervised principal component analysis (SPCA). The method comprises: (a) designing a plurality of calibration samples wherein the desired variances are dominant or greatly enhanced; (b) producing a calibration data matrix using suitable mathematical pretreatment and truncation of the acquired NIR/Raman spectra of the calibration samples; (c) decomposing the matrix using PCA; (d) evaluating the score and loading matrices to ensure a genuine orthogonal relationship between scores of the desired latent variables in a two-dimensional principal component space 09-08-2011
20080198376OPTICAL SENSOR WITH LAYERED PLASMON STRUCTURE FOR ENHANCED DETECTION OF CHEMICAL GROUPS BY SERS - An optical sensor and method for use with a visible-light laser excitation beam and a Raman spectroscopy detector, for detecting the presence chemical groups in an analyte applied to the sensor are disclosed. The sensor includes a substrate, a plasmon resonance mirror formed on a sensor surface of the substrate, a plasmon resonance particle layer disposed over the mirror, and an optically transparent dielectric layer about 2-40 nm thick separating the mirror and particle layer. The particle layer is composed of a periodic array of plasmon resonance particles having (i) a coating effective to binding analyte molecules, (ii) substantially uniform particle sizes and shapes in a selected size range between 50-200 nm (ii) a regular periodic particle-to-particle spacing less than the wavelength of the laser excitation beam. The device is capable of detecting analyte with an amplification factor of up to 1008-21-2008
20080198375Downhole laser measurement system and method of use therefor - A downhole laser measurement system useful for evaluating the chemical or elemental composition of geologic formations or formation fluids or interrogating a fiber optic sensor includes a pressure housing, wherein the pressure housing further includes a laser disposed in communication with a laser temperature control chamber; a laser light feedthrough; and an optical sensor array. An associated method of using a laser measurement system in a downhole well bore includes disposing a laser measurement system downhole in a well bore; using the laser to create a laser light, and then outputting the light to an optical sensor array.08-21-2008
20110249259Single Molecule Optical Spectroscopy in Solid-State Nanopores in a Transmission-Based Approach - Methods and apparatus in the field of single molecule sensing are described, e.g. for molecular analysis of analytes such as molecular analytes, e.g. nucleic acids, proteins, polypeptides, peptides, lipids and polysaccharides. Molecular spectroscopy on a molecule translocating through a solid-state nanopore is described. Optical spectroscopic signals are enhanced by plasmonic field-confinement and antenna effects and probed in transmission by plasmon-enabled transmission of light through an optical channel that overlaps with the physical channel.10-13-2011
20090161101METHOD AND APPARATUS FOR DETERMINING CHANGE IN AN ATTRIBUTE OF A SAMPLE DURING NUCLEATION, AGGREGATION, OR CHEMICAL INTERACTION - The present disclosure describes methods and apparatus to produce a streaming image of a sample during a time period when an attribute of the sample is changing. The streaming image can be viewed in such a manner so as to be able to follow a visible change in an attribute of the sample. The sample may be undergoing nucleation, aggregation, or chemical interaction. The present disclosure also describes methods and apparatus to determine a change in an attribute of a sample by detecting, analyzing, and comparing spectra of the sample taken at different times during the time period when the attribute of the sample is changing. The sample may be undergoing nucleation, aggregation, or chemical interaction.06-25-2009
20120274936SOLUTION SAMPLE PLATE WITH WELLS DESIGNED FOR IMPROVED RAMAN SCATTERING SIGNAL DETECTION EFFICIENCY - Devices, methods of using the device, systems including the device that include a sample plate with sample containers (wells), wherein at least a portion of the surface of the sample plate and/or sample containers is coated with an optical reflective material. The optical reflective material, provides enhanced excitation signal intensity and enhanced Raman signal intensity. Such enhancement provides improved total signal detection capabilities, and methods of improved focusing algorithms.11-01-2012
20120274935DETECTION DEVICE - A detection device includes a sensor chip, a suction section adapted to suck a fluid sample to the sensor chip, a light source adapted to irradiate the sensor chip, a light intensity adjustment section adapted to adjust intensity of the light, a light detection section adapted to detect the light reflecting the sample adsorbed to the sensor chip, and a control section adapted to perform drive control on the suction section. The control section sets the suction flow velocity to V1 in the first mode in which the light detection section performs the detection, and sets the suction flow velocity to V2 (V2>V1) in the second mode. The light intensity adjustment section sets the light intensity to L1 in the first mode, and sets the light intensity to L2 (L2>L1) in the second mode. The first and second modes are switched based on the signal from the light detection section.11-01-2012
20120274934METHOD AND APPARATUS FOR EVALUATING A SAMPLE THROUGH VARIABLE ANGLE RAMAN SPECTROSCOPY - Described are systems and methods for variable angle Raman spectroscopy, in which electromagnetic radiation will be caused to intersect the sample under investigation at a plurality of angles of incidence, so as to provide Raman scattering spectra at each angle. One example use of measuring such spectra at multiple angles of incidence is to enable evaluation at a plurality of depths within the sample. In many implementations, the range of the angles of incidence will include, and extend to either side, of the critical angle.11-01-2012
20120274933Detection system for airborne particles - This invention relates to a detection system for particles suspended in a gas. The detection system includes an electrostatic precipitator constructed to collect the particles from the gas onto a collection surface using the force of an induced electrostatic charge on the particles. The detection system also includes an optical probe coupled with the electrostatic precipitator and constructed to probe the particles with a beam in order to detect the particles. The body of the electrostatic precipitator has a geometry that allows the beam to travel from the optical probe to the collection surface.11-01-2012
20100309464Raman Chemical Imaging of Threat Agents Using Pulsed Laser Excitation and Time-Gated Detection - The disclosure provides for a system and method for detecting a threat agent. A sample is illuminated to produce photons Raman scattered and emitted by the sample. The Raman scattered photons are collected using time-gated detection without collecting the emitted photons. A Raman spectroscopic data set is generated from said Raman scattered photons wherein said Raman spectroscopic data comprises at least one of a Raman spectrum and a Raman chemical image. The Raman spectroscopic data is assessed to thereby determine the presence or absence of a threat agent in the sample. The sample may be in a target area. The sample may be illuminated using a pulsed laser or an intensity modulated laser. The illumination source may be synchronized with a gating element that enables time-gated detection.12-09-2010
20130182247Compact, Low Cost Raman Monitor For Single Substances - Apparatus for performing Raman spectroscopy may include a first laser source having a first emission wavelength and a second laser source having a second emission wavelength. A separation between the first and second emission wavelengths may correspond to a width of a Raman band of a substance of interest. An optical switch may provide switching between the first and second laser sources. An ensemble of individually addressable laser emitters may be provided. A Bragg grating element may receive laser light from the ensemble. An optical system may direct light from the Bragg grating element into an optical fiber. A combined beam through the optical fiber may contain light from each of the emitters.07-18-2013
20130182248LIGHT MEASUREMENT METHOD AND MEASUREMENT APPARATUS USING AN OPTICAL FIELD ENHANCEMENT DEVICE - Performing a measurement using an optical field enhancement device which includes a transparent substrate having a transparent fine uneven structure on a surface and a metal film formed on a surface of the fine uneven structure on the surface of the substrate, in which a subject is placed on the metal film of the optical field enhancement device, then excitation light is projected onto an area of the optical field enhancement device on which the subject is placed, and light generated by the projection of the excitation light is detected from a back surface side of the transparent substrate.07-18-2013
20130182249NANOSCALE POROUS GOLD FILM SERS TEMPLATE - Provided are patterned nanoporous gold (“P-NPG”) films that may act as at least one of an effective and stable surface-enhanced Raman scattering (“SERS”) substrate. Methods of fabricating the P-NPG films using a low-cost stamping technique are also provided. The P-NPG films may provide uniform SERS signal intensity and SERS signal intensity enhancement by a factor of at least about 1×1007-18-2013
20130176563Biopolymer Optical Analysis Device and Method - The present invention provides a device and method for analyzing the characteristics of a biopolymer with excellent mechanical stability, high spatial resolution and sensitivity using a simple device construction. Specifically, the Raman scattered light of a biopolymer is measured and the properties of monomer units forming the biopolymer are analyzed by using a biopolymer property analysis chip (07-11-2013
20120281213SORTING PROCESS OF NANOPARTICLES AND APPLICATIONS OF SAME - In one aspect of the present invention, a method for sorting nanoparticles includes preparing a high-viscosity density gradient medium filled in a container, dispersing nanoparticles into an aqueous solution to form a suspension of the nanoparticles, each nanoparticle having one or more cores and a shell encapsulating the one or more cores, layering the suspension of the nanoparticles on the top of the high-viscosity density gradient medium in the container, and centrifugating the layered suspension of the nanoparticles on the top of the high-viscosity density gradient medium in the container at a predetermined speed for a predetermined period of time to form a gradient of fractions of the nanoparticles along the container, where each fraction comprises nanoparticles in a respective one of aggregation states of the nanoparticles.11-08-2012
20120281212SELF-COLLECTING SERS SUBSTRATE - A self-collecting substrate (11-08-2012
20120281211MINIATURIZED MULTIMODAL CARS ENDOSCOPE - A miniaturized imaging system is provided that operates in multiple modes, including a coherent anti-stokes Raman scattering (CARS) mode. The imaging system includes: a laser delivery subsystem that generates an excitation signal; a scanning mechanism configured to receive the excitation signal from the laser delivery subsystem and direct the excitation signal through an optics subsystem onto a sample, such that the optics subsystem compensates for chromatic aberration in the excitation signal; and a dichroic mirror that receives emission from the sample in a backward direction and directs the emission along a collection path to a detector. The light source for the laser delivery subsystem may be a single femtosecond pulse laser.11-08-2012
20120281210Nano-/Micro-Droplets for the Detection of Analytes - For a rapid and real-time SERS detection of organic chemicals in the air and the interfaces of air/solids, colloidal silver and/or gold nanoparticles solution is sprayed, in the form of nano-/micro-sized droplets, at the desired target area where the analytes of interest are present, e.g., in the air or onto certain organic/inorganic interfaces.11-08-2012
20120281209Fiber Based SERS Sensor - Methods and systems for enhanced SERS sensing are disclosed, including generating electromagnetic radiation from a fiber laser; coupling the radiation to a SERS sensor comprising: a fiber comprising a first end and a second end, wherein the first end is coupled to the fiber laser and the second end is deposited with one or more metal nanoparticles; an in-line fiber grating integrated into the fiber between the first and the second end; a spectrometer configured to measure a spectrum produced by the in-line fiber grating; and a micro-processor configured to control the fiber laser and the spectrometer; exciting one or more molecules adsorbed on the surface of the one or more metal nanoparticles to generate a Raman signal; coupling the signal into the fiber; separating the signal into its wavelength components with the in-line fiber grating; and measuring the wavelength components with the spectrometer. Other embodiments are described and claimed.11-08-2012
20130155402INLINE SPECTROSCOPIC READER AND METHODS - An inline spectroscopic reader having a light source, one or more optics heads, a spectrometer and a data processing system in digital communication with the spectrometer detector. The optics heads include transmission optics providing for the illumination of a target with light from the light source and detection optics providing for the collection of light from the target. Typically, the target is moving with respect to the optics head during spectroscopic interrogation. The spectroscopic reader is thus an inline reader well suited to provide spectrum based production or analytical decision making in real time as the target moves along a production or analysis line. Also disclosed are methods including the steps of illuminating a target with light from a light source; collecting light from the target; obtaining a digitized spectrum with a spectrometer; extracting information content from the digitized spectrum; and basing a contemporaneous process decision upon the information content.06-20-2013
20110279817OPTICAL DEVICE AND ANALYZING APPARATUS - An optical device includes a projection group in which electrically conductive projections are arranged along a direction parallel to a virtual plane. The arrangement period of the projections in the projection group includes at least a first period and a second period different from the first period. The first period and the second period are shorter than a wavelength of an incident light.11-17-2011
20130188181Systems and Methods for Spatial Heterodyne Raman Spectroscopy - The present subject matter is directed to a device for spectroscopy. The device includes an excitation source configured to illuminate a sample with wavelengths. The device also includes a spatial heterodyne interferometer configured to receive Raman wavelengths from the sample.07-25-2013
20130188182Raman Apparatus and Method for Real Time Calibration Thereof - A Raman spectrometer optically separates an optical signal scattered by a sample from an incident excitation light beam into an unshifted return component at a first wavelength and one or more Raman scattered components at shifted wavelengths characteristic of the sample. The unshifted return component—but not the Raman scattered components—is attenuated prior to impinging on an optical detector. The unshifted return then serves as the basis for real-time calibration to account for fluctuations in optical intensity, wavelength shift, and/or spectral peak width, based on a comparison of the unshifted return peak to a reference standard for stable reflectance.07-25-2013
20120019820Compact, Low Cost Raman Monitor For Single Substances - Apparatus for performing Raman analysis may include a laser source module, a beam delivery and signal collection module, a spectrum analysis module, and a digital signal processing module. The laser source module delivers a laser beam to the beam delivery and signal collection module. The beam delivery and signal collection module delivers the laser source beam to a sample, collects Raman scattered light scattered from the sample, and delivers the collected Raman scattered light to the spectrum analysis module. The spectrum analysis module demultiplexes the Raman scattered light into discrete Raman bands of interest, detects the presence of signal energy in each of the Raman bands, and produces a digital signal that is representative of the signal energy present in each of the Raman bands. The digital signal processing module is adapted to perform a Raman analysis of the sample.01-26-2012
20120019819RAMAN SPECTROSCOPY USING MULTIPLE DISCRETE LIGHT SOURCES - Raman spectroscopy apparatuses are described that detect the spectral characteristics of a sample wherein the apparatus consists of a multiplicity of modulated discrete light sources adapted to excite a sample with electromagnetic radiation, a filter adapted to isolate a predetermined wavelength emitted by the sample wherein the wavelength is further modulated at different frequencies, and a detector for detecting the isolated wavelength. The apparatus may further consist of an interferometer, such as a Michelson interferometer, adapted to modulate the excitation energy. Also provided herein are methods, systems, and kits incorporating the Raman spectroscopy apparatus.01-26-2012
20120019818Apparatus and Methods for Fluorescence Subtraction in Raman Spectroscopy - An improved apparatus and method for fluorescence subtraction in Raman spectroscopy, where a narrow band light source and a broad band light source are utilized to stimulate Raman scattering and fluorescence emission from the same subject to produce two Raman/fluorescence spectra. The two light sources, with matched output power, produce similar level of fluorescence emission, yet the Raman scattering signal produced by the broad band light source has much lower spectral intensity than that produced by the narrow band light source. By subtracting the two Raman/fluorescence spectra, the weak Raman signal can be extracted from a strong fluorescence background.01-26-2012
20130194570APPARATUS FOR PERFORMING SPECTROSCOPY - An apparatus for performing spectroscopy includes an optical waveguide comprising a fluidic channel to receive a fluid sample, in which the optical waveguide is to propagate lightwaves at a set of frequencies. The apparatus also includes a wavelength selective device coupled to the optical waveguide, in which the wavelength selective device comprises a predetermined bandwidth and is to capture frequencies of light within the predetermined bandwidth. The apparatus further includes a detector coupled to the wavelength selective device to generate signals that identify the frequencies captured by the wavelength selective device.08-01-2013
20090086202NON-INVASIVE DISEASE DIAGNOSIS USING LIGHT SCATTERING PROBE - A method for non-invasive detection of a disease, a status of illicit-drug use, or smoking status includes transferring a body fluid obtained from a patient to a sensor comprising a nano-scale surface structure to allow the body fluid to come in contact with the nano-scale surface structure, illuminating the body fluid and the nano-scale surface structure by a laser beam, scattering the laser beam by the body fluid and the nano-scale surface structure to produce a scattered light, and analyzing the scattered light using a spectral analyzer to diagnose a disease, the status of illicit-drug use, or smoking status in the patient.04-02-2009
20120075627FIBER PROBE BASED MICROFLUDIC RAMAN SPECTROSCOPY - A microfluidic device comprising at least one microfluidic channel with an input and an output for allowing fluid flow; and at least one Raman fiber based probe having an excitation fiber probe and/or a collection fiber probe positioned so that one end of the probe is in the microfluidic channel.03-29-2012
20130094022ELECTRODE FOR PRODUCING A PLASMA, PLASMA CHAMBER HAVING SAID ELECTRODE, AND METHOD FOR ANALYZING OR PROCESSING A LAYER OR THE PLASMA IN SITU - A RF electrode for generating, plasma in a plasma chamber comprising an optical feedthrough. A plasma chamber comprising an RF electrode and a counter-electrode with a substrate support for holding a substrate, wherein a high-frequency alternating field for generating the plasma can be formed between the RF electrode and the counter-electrode. The chamber comprising an RF electrode with an optical feedthrough. A method, for in situ analysis or in situ processing of a layer or plasma in a plasma chamber, wherein the layer is disposed on counter-electrode and an RF electrode is: disposed on the side lacing the layer. Selection of an RF electrode having an optical feedthrough, and at least one step in which electromagnetic radiation is supplied through the optical feedthrough for purposes of analysis or processing of the layer or the plasma, and by at least one other step in which the scattered or emitted or reflected radiation is supplied to an analysis unit.04-18-2013
20130208272METHOD AND APPARATUS FOR NON-RESONANT BACKGROUND REDUCTION IN COHERENT ANTI-STOKES RAMAN SCATTERING (CARS) SPECTROSCOPY - Embodiments of the invention provide a simple and robust system that allows non-resonant background to be removed from anti-Stokes signals generated during coherent anti-Stokes Raman spectroscopy (CARS) even when using cheaper laser systems, which do not have transform limited pulses. In particular, resonant CARS signals have a real and imaginary component. The imaginary component is directly related to the spontaneous Raman spectrum, for which there are already large spectral databases to allow chemical identification. The NRB signal, on the other hand, only has a real component. Within embodiments of the invention we recover the imaginary component of the entire CARS signal by simultaneously generating two CARS signals at orthogonal polarisations: one has the imaginary components destructively interfering with (i.e. subtracted from) the real components, the other has them constructively interfering. Measuring these two polarisations and subtracting them therefore cancels out the real part of the signal, leaving only the imaginary components.08-15-2013

Patent applications in class With Raman type light scattering