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BLOOD ANALYSIS

Subclass of:

356 - Optics: measuring and testing

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Class / Patent application numberDescriptionNumber of patent applications / Date published
356040000 Hemoglobin concentration 20
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DocumentTitleDate
20130083311MICROFLUIDIC SYSTEM FOR OPTICAL MEASUREMENT OF PLATELET AGGREGATION - Described herein in several embodiments are a system, method and apparatus for measuring platelet thrombus volume of a blood sample. In some embodiments, the present invention comprises a microfluidic apparatus having a blood input that receives the blood sample and a plurality of flow channels. In some embodiments of the present invention, each flow channel has a non-stenotic region that receives a portion of the blood sample from the blood input and a stenotic region for creating a discrete initial shear rate in the flow channel. The initial shear rate in the flow channel can be from approximately 500 s04-04-2013
20090219509Optical sensor with enhanced reflectance - A device for determination of analytes is disclosed that comprises an optical material having a deposit on a surface thereof, where this deposit includes an analyte-reactive reagent and a particulate means for enhancing reflectance of a light beam emitted through the optical material into the analyte-reactive reagent. The enhanced reflectance provides a return of light through the optical material at a level which is not only analytically useful, but involves sufficient returned light intensity so as to enable markedly improved accuracy in analytical determinations. The particulate means most preferably includes hollow spherical particles.09-03-2009
20080259313Apparatus for Performing Optical Measurements on Blood Culture Bottles - An apparatus and method for rapidly distinguishing positive blood cultures from negative blood cultures in sealable containers, and for determining the combination of blood volume and hematocrit in a sealable container. The apparatus comprises an optical source for illuminating the culture with a light beam under an oblique angle to generate an asymmetric spatial distribution of backscattered light, which is imaged onto an imaging detector connected to a data analyzer.10-23-2008
20130077085Measuring Volume and Constituents of Cells - A method of determining a volume of a platelet includes: (a) illuminating the platelet with incident light at a plurality of illumination wavelengths; (b) obtaining at least one two-dimensional image of the platelet corresponding to each illumination wavelength; (c) for each illumination wavelength, determining a mean optical density and a maximum optical density for the platelet; (d) determining an area of the platelet; (e) for each illumination wavelength, determining a volume of the platelet; (f) for each illumination wavelength, determining an integrated optical density for the platelet; and (g) determining the volume of the platelet based on a weighted combination of the area of the platelet, the volumes of the platelet corresponding to each of the illumination wavelengths, and the integrated optical densities for the platelet corresponding to each of the illumination wavelengths.03-28-2013
20130033697DEVICE FOR DETERMINING A CONCENTRATION OF A CONSTITUENT OF BLOOD IN A HOSE LINE - A device for determining the concentration of a constituent of blood in a hose line, in particular in the hose line of an extracorporeal blood circuit of an extracorporeal blood treatment apparatus, includes a clamping unit having an actuation mechanism configured to apply a clamping force such that first and second receiving elements are moved towards one another from a first position releasing the hose line into a second position clamping the hose line, in which the drive of the actuation mechanism takes place with an electric motor, and a monitoring unit configured to detect a hose line inserted into the receiving elements. A method for detecting a hose line in a clamping unit of a device for determining the concentration of a blood constituent in the hose line is also described. Automation of the measurement of the blood parameters is thus possible.02-07-2013
20130038860BLOOD ANALYSIS APPARATUS AND BLOOD ANALYSIS METHOD - A blood analysis apparatus includes an analysis section. The analysis section is configured to compare a measurement spectrum obtained regarding red blood cells with a standard spectrum of heme, biliverdin, and bilirubin, and cause the measurement spectrum to belong to any one of the standard spectra.02-14-2013
20090303462Correlation technique for analysis of clinical condition - The present invention provides a correlation technique for analysis of changes in bodily fluid and/or tissue in order to identify or monitor appearance, progression or treatment of a disease or condition in a subject. The disclosed method involves measuring spectral properties or changes in bodily fluid and/or tissue of a subject using at least two optical techniques; and correlating the measured properties or changes to a corresponding clinical condition or change in clinical condition, respectively. The measure of spectral changes over time can be used as indicators of changes in the clinical condition, for example, in disease treatment and/or disease regulation. This method is particularly useful for identifying a disease state and for monitoring efficacies of therapies used to treat different diseases or disorders, for example, renal dialysis.12-10-2009
20120218541SHROUDED SENSOR CLIP ASSEMBLY AND BLOOD CHAMBER FOR AN OPTICAL BLOOD MONITORING SYSTEM - An optical blood monitoring system for blocking unwanted light from reaching sensors in a sensor clip assembly fastened to a blood chamber connected in an extracorporeal blood treatment system. The sensor clip assembly includes opposing heads with LED emitters and photodetectors. In one embodiment, lenses in the heads are surrounded by shrouds extending from the lenses so that when the sensor clip assembly is fastened to the blood chamber the shrouds block unwanted light from reaching the photodctectors. Either alternatively or as a complement to the shrouds, the blood chamber includes an opaque portion or a portion colored to attenuate particular wavelengths of light to further enhance the overall ability of the blood chamber and sensor clip assembly to block unwanted light from reaching the photodetectors.08-30-2012
20090091741Optical coagulation monitor and method of use - An optical coagulation monitor and the method of monitoring blood coagulation status are disclosed. The method includes positioning a sample probe containing an optical fiber within a circulating blood; transmitting a low-coherence light through the optical fiber into the blood; detecting dynamic light scatter signals generated by the blood within a coherence volume and received through the optical fiber; analyzing the dynamic light scatter signals in comparison to a predetermined coagulation criterion; and reporting the coagulation status of the blood. The method can be used for monitoring blood coagulation status in vivo or in vitro in real time. Further disclosed is a method of determining blood clotting time in vitro using the optical coagulation monitor.04-09-2009
20090268194BLOOD ANALYSIS APPARATUS AND SETTING METHOD OF MEASUREMENT POSITION IN BLOOD ANALYSIS APPARATUS - A blood analysis apparatus is provided. The blood analysis apparatus includes: a chip holding portion having an aperture which allows light to pass therethrough and holding a μ-TAS chip for holding a measurement liquid; a rotary body on which the chip holding portion is mounted; a light source; and a light-receiving unit. A measurement position of the rotary body at which the measurement liquid is to be measured with the light from the light source is set by: rotating the rotary body to obtain a light value of light which is emitted from the light source and received by the light-receiving unit through the aperture; and setting a rotational position of the rotary body where the light value is a threshold value or more, as the measurement position.10-29-2009
20090185160MEASURING DEVICE FOR DETERMINING THE SIZE, SIZE DISTRIBUTION AND QUANTITY OF PARTICLES IN THE NANOSCOPIC RANGE - The present invention relates to a measuring device to determine the size, size distribution and/or concentration of nanoscopic particles or hollow spaces in a measuring sample, the degree of opacity of such measuring samples, or the degree of roughness of surfaces by determining the wavelength and scattering angle dependent intensities of a measuring radiation scattered on a measuring sample, comprising a retaining device for a measuring sample to be measured, a detector, comprising at least one detector inlet, an evaluation unit and at least two radiation sources, which are respectively at a distance from each other and at a distance from the measuring sample, which comprise a multiple wavelength spectrum or a continuous spectrum, and the radiation intensities of which are adjustable and/or determinable, wherein via the radiation sources one ray bundle can in each case be emitted in an essentially parallel beam in the direction of a measuring sample, and wherein the ray bundles which can be directed onto the measuring sample, which have different radiation sources in relation to the axis between the detector inlet and the measuring sample, are aligned or can be aligned in different angles onto the measuring sample.07-23-2009
20090073418CELL COUNTING BOARD - [Problems] A disposable cell counting board in which a space formed by a counting board body and an upper plate is fixed in advance, and which does not require assembling by a cell counting worker, and which can be mass-produced at low costs, is provided.03-19-2009
20090168049METHOD AND APPARATUS FOR MEASURING ANALYTES - A method for measuring the concentration of a compound in the blood of a part of a subject is provided. An invasive or non-invasive sample of blood may be used for this determination. Also provided is a device for measuring the concentration of a compound in the blood of a subject. The device comprises a source of electromagnetic radiation, a holder, a detector and a processing system.07-02-2009
20100201968METHOD AND APPARATUS FOR PERFORMING OPTICAL MEASUREMENTS OF A MATERIAL - A method of determining an optical parameter or function thereof for a liquid, the method comprising: flowing the liquid through a flow cell; transmitting a pulse of light into the liquid in the flow cell; generating a signal responsive to energy that the material emits responsive to a portion of the light from the light pulse that is absorbed by the liquid; and using the signal to determine the optical parameter or function thereof.08-12-2010
20090002683Small Volume in Vitro Analyte Sensor - A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable.01-01-2009
20110216308COMPONENT MEASUREMENT APPARATUS - A component measurement apparatus includes a laser that emits non-collimated laser light, an objective lens that condenses the non-collimated laser light emitted from the laser in order for the laser light to illuminate internal tissue of an object of measurement without collimating the laser light, a half mirror that redirects reflected light reflected by the internal tissue of the object of measurement and refracted by the objective lens, a pin hole through which the reflected light redirected by the half mirror passes, a light-receiving element that receives the reflected light having passed through a pin hole, and a data analyzer section that measures a component of the object of measurement in accordance with data output from the light-receiving element.09-08-2011
20110216309COMPONENT MEASUREMENT APPARATUS - A component measurement apparatus includes a confocal optical system including a laser emitting laser light, a collimating lens collimating the laser light emitted from the laser, an objective lens condensing the collimated light having exited the collimating lens in order to illuminate internal tissue of an object of measurement, a half mirror redirecting reflected light reflected by the internal tissue of the object of measurement and refracted by the objective lens, a pin hole through which the reflected light redirected by the half mirror passes, and a light-receiving element receiving the reflected light having passed through the pin hole. The component measurement apparatus also includes a data analyzer section measuring a component of the object of measurement in accordance with data output from the light-receiving element. In the component measurement the apparatus, a focal position of the objective lens is adjustable along an optical axis.09-08-2011
20090122299Optical Sub Wavelength Super Resolution Imaging System and Method - An imaging method and system are presented for use in sub-wavelength super resolution imaging of a subject. The imaging system comprises a spatial coding unit configured for collecting light coming from the scanned subject and being spaced from the subject a distance smaller than a wavelength range of said light; a light detection unit located upstream of the spatial coding unit with respect to light propagation from the object, and configured to define a pixel array and a spatial decoding unit, which is associated with said pixel array and is configured for applying spatial decoding to a magnified image of the scanned subject, thereby producing nanometric spatial resolution of the image.05-14-2009
20090310122BLOOD ANALYZER, SAMPLE ANALYZER, AND FLOW CYTOMETER - A sample analyzer is provided that is capable of eliciting sufficient performance of an avalanche photodiode, and performing high-precision analysis of the sample. The sample analyzer is provided with a WBC detection section that uses the avalanche photodiode as a photoreceptor element. The WBC detection section is provided with a flow cell, semiconductor light source, side collective lens, dichroic mirror, and avalanche photodiode. The side collective lens is a lens with a high NA (numeric aperture), and an aspheric lens with a small aberration. The sample analyzer prepares a scattergram using side fluorescent light signals and side scattered light signals to classify white blood cells into five categories.12-17-2009
20090079963Device and method for the detection of particles - The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or the second surface. The invention also relates to corresponding methods for the detection of particles, comprising positioning a sample supposed to comprise one or more species of particles to be detected in a reaction chamber, displacing at least a part of the sample within the reaction chamber via the one or more displacers; and detecting/determining a value indicative for the presence and/or number of one or more species of particles.03-26-2009
20080278707CYTOLOGICAL IMAGING SYSTEM AND METHOD - The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.11-13-2008
20090251683VIRTUAL SEPARATION OF BOUND AND FREE LABEL IN A LIGAND ASSAY FOR PERFORMING IMMUNOASSAYS OF BIOLOGICAL FLUIDS, INCLUDING WHOLE BLOOD - Detection and characterization of immunologically detected substances are performed electronically on human and animal biological fluids such as whole blood, serum, plasma, urine, milk, pleural and peritoneal fluids, and semen, which fluids are contained in a thin chamber forming a quiescent fluid sample, which chamber has at least two parallel planar walls, at least one of which is transparent.10-08-2009
20090079962Tank for an Optical Device for Blood Analysis, Analysis Apparatus Equipped With Such a Tank - A flow-through tank 03-26-2009
20090079964OPTICAL DEVICE COMPONENTS - Embodiments of the invention relate to a light illumination funnel. The funnel includes a first opening positioned to receive an incoming light source, a second opening positioned opposite the first opening and with a diameter smaller than the first opening and inner reflective walls, in contact with the first opening and second opening. The funnel has a half angle of less than 25 degrees. Embodiments also relate to a light collection funnel and an apparatus utilizing both a light illumination funnel and light collection funnel.03-26-2009
20080316466Spectroscopic Optical System - Innovative techniques that result in a better signal-to-noise ratio for spectrographic analysis of substances in a target than conventional techniques. In these techniques, light illuminates a target with at least some of the light penetrating the target. At least a portion of the light that penetrates the target is collected from a region on the target's surface that is not directly illuminated. Preferably, at least a majority of the collected light is light that penetrates the target. Also preferably, the light that illuminates the target is in a pattern that partially but not completely surrounds the region from which the portion of the light that penetrates the target is collected. A spectrum of at least a portion of the collected light is analyzed.12-25-2008
20090213360DEVICE AND METHOD FOR IN VITRO DETERMINATION OF ANALYTE CONCENTRATION WITHIN BODY FLUIDS - A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.08-27-2009
20090009750Method for automatically detecting factors that disturb analysis by a photometer - The invention concerns a method for detecting the amounts of substances that may disturb chemical analysis performed by an analyzer for clinical chemistry. The presence and concentration of hemoglobin, bilirubin and lipemia are detected by measuring the absorbance or reflectance on at least two, preferably six, different wavelengths over the measured spectrum. The measurements are performed at two wavelengths for each substance, preferably on the absorbance peaks of the specific substance and on the root of the specific peaks. Since the three substances mentioned above each have at least one peak in the spectrum, the measurement is done on three peaks and three root positions respectively when three substances have to be measured.01-08-2009
20100014068MINIATURIZED CYTOMETER FOR DETECTING MULTIPLE SPECIES IN A SAMPLE - A system for scattered light and simultaneous multi-color (e.g., greater than sixteen colors) fluorescence light detecting, and for analyzing, classifying and identifying biological particles and items of interest. A sample to be tested may be entered in a disposable microfluidic cartridge which in turn is insertable in a portable, hand-holdable, or wearable miniaturized cytometer instrument. The present system may be incorporated in the cytometer instrument. It may have significant application relative to biological warfare, environmental substances, the medical field and other fields.01-21-2010
20100165324RAMAN SPECTROSCOPIC MONITORING OF HEMODIALYSIS - Spectroscopic systems and methods are disclosed for determining levels of at least one analyte in blood undergoing hemodialysis. In one aspect, the invention employs Raman spectroscopy to monitor and/or control hemodialysis. In one embodiment, the system uses a laser light directed to circulating blood from a patient undergoing dialysis to make Raman spectral measurements. For example, the laser light can be directed into a segment of the dialysis tubing. The system can utilize unique Raman spectroscopic signature of one or more analytes, e.g., urea, to identify and quantify such analytes against a whole blood background. Based on the spectral response, the concentration of the analytes can be monitored and/or used to control hemodialysis.07-01-2010
20100259747SAMPLE DETECTOR AND MEASUREMENT DEVICE EQUIPPED WITH THE SAME - A sample detector B includes a member 10-14-2010
20100177300MEASURING DEVICE - A measuring device includes a VCSEL of a first-order or high-order single mode emitting laser beams, a driving part configured to drive the VCSEL, a detecting part configured to detect an electric signal relating to feedback lights generated when laser beams are projected onto an object, and a calculating part configured to identify a direction of movement of the object on the basis of the electric signal detected by the detecting part.07-15-2010
20090115996DETECTING MICROORGANISMS IN BLOOD UTILIZING PHYSICAL AND CHEMICAL CHANGES IN BLOOD - An approach to detecting microorganisms in blood uses the changes of hemoglobin and the physical and chemical properties of blood to detect the presence of microorganisms in blood. Spectrophotometric measurements are taken several wavelengths across the UV-Vis-NIR portion of the electromagnetic spectrum, and a deconvolution is performed quantitatively to interpret distinct spectral characteristics of blood enabling the detection of microorganisms.05-07-2009
20110109897MEASURING APPARATUS - An apparatus comprising at least one measuring cell (05-12-2011
20110026009Surface Mapping by Optical Manipulation of Particles in Relation to a Functionalized Surface - Methods and apparatus for analyzing surface properties of particles are provided. A method for analyzing the surface properties of the particle includes a associating a first particle with a first capture zone having a specific binding affinity for a first chemical species, applying an optical force to the first particle, sensing a response of the first particle to the optical force, and using the sensed response to determine the presence, absence or quantity of the first chemical species on the first particle surface. This process may be repeated in parallel to test multiple particles. In addition to directly testing the surface properties of the particles, the method can be used in direct, indirect and competitive assays to determine the presence, absence or quantity of free or immobilized analytes. A fluidic cartridge with capture zones having avidities that are tuned for the use of optical forces is provided. A software routine for performing the method is also provided.02-03-2011
20100026986Method and Apparatus for Separating A Composite Liquid Into At Least Two Components And For Determining The Yield Of At Least One Component - Method and Apparatus for predicting the yield of a selected cellular component from a composite blood product by sensing the movement of the separated cellular component or another component during expression from a separation container to a collection container to produce a signal indicative of the movement, and predicting the yield of the separated cellular component from the signal.02-04-2010
20090219510Nonhemolytic optical sensor with enhanced reflectance - A nonhemolytic sensor for determination of analytes in erythrocyte-containing biological fluids is disclosed that comprises an optical material having a deposit on a surface thereof, where this deposit includes an analyte-reactive reagent and a particulate means for suppressing hemolysis of erythrocytes in an erythrocyte-containing biological fluid, such as whole blood. Thus, a porous array of negatively charged particles, e.g., polymeric beads having a plurality of carboxylate surface groups, are disposed on a sampling surface of an optical sensor, and suppress hemolysis of erythrocytes coming into contact with the sampling surface. In the case of an optical sensor, such particles can simultaneously enhance reflectance of a light beam transmitted through the optical material to the sampling surface site.09-03-2009
20100220312BLOOD EXAMINATION APPARATUS - This blood examination apparatus examines cancer cells mixed in an examination object which is flowing blood, and includes: a flow cell through which the examination object is made to flow; an imaging optical system which light output from the examination object in an examination region in the flow cell enters, the imaging optical system forming an image of the light on a first image plane; a first Fourier transformation optical system which optically two-dimensionally Fourier-transforms the image formed on the first image plane by the imaging optical system to form the Fourier-transformed image on a second image plane; a spatial light filter which selectively allows a portion in a certain range around an optical axis of the first Fourier transformation optical system of the image formed on the second image plane by the first Fourier transformation optical system to pass through; and a second Fourier transformation optical system which optically two-dimensionally Fourier-transforms the portion which has passed through the spatial light filter of the image formed on the second image plane by the first Fourier transformation optical system to form the Fourier-transformed image on a third image plane.09-02-2010
20090109422DETECTING ELEMENT, DETECTING DEVICE AND DETECTING METHOD - The present invention provides a detecting element which can stably detect a substance with high sensitivity; a detecting device therefor; and a detecting method therefor. The detecting element and the detecting device according to the present invention have a plurality of planes having a plurality of mutually-separated metallic structures arranged thereon. The detecting method according to the present invention includes making a detecting light irradiate the detecting element so that the light can intersect a plurality of the planes. Thereby, the detecting light is more frequently absorbed in the vicinity of the metallic structure and the detecting device can stably detect a slight change of a spectrum originating from a trace change of a refractive index occurring in the vicinity of the metallic structure, with the high sensitivity.04-30-2009
20100110415Analyzer and analytic system - This analyzer comprises a photoirradiation portion simultaneously photoirradiating a plurality of storage vessels storing a plurality of measurement samples respectively and a plurality of photodetection portions detecting a plurality of light components resulting from simultaneous photoirradiation on the plurality of storage vessels storing the plurality of measurement samples respectively. The photoirradiation portion includes a light source, a first light guide portion branching light emitted from the light source into a plurality of light components and guiding the plurality of light components to the plurality of measurement samples respectively and a second light guide portion branching light emitted from the light source into a plurality of light components and guiding the plurality of light components to the plurality of measurement samples respectively.05-06-2010
20100066996Sample analyzer - The present invention is to present a sample analyzer, comprising: an imaging device for imaging a sample container which has translucency and contains a sample; a measuring device for aspirating the sample contained in the sample container and measuring the aspirated sample; a transporting device for transporting the sample container to a supply position for supplying the sample contained in the sample container to the measuring device; a sample volume obtainer for obtaining sample volume information relating to volume of the sample in the sample container, based on an image obtained by imaging the sample container by the imaging device; and a transport controller for controlling the transporting device to perform a transport operation in accordance with the sample volume information obtained by the sample volume obtainer.03-18-2010
20100165325OPTICAL SYSTEM FOR A PARTICLE ANALYZER AND PARTICLE ANALYZER USING SAME - A compact optical system for a particle analyzer and particle analyzer using same are provided. The optical system for a particle analyzer of the present invention comprises a light source, an irradiation optical system for irradiating particles passing through a flow cell with light from the light source, a photodetector for receiving the scattered light from the particles, a light shielding member for blocking the direct light from the light source from impinging the photodetector, and a detecting lens for directing the scattered light toward the photodetector, wherein the irradiation optical system forms a first focus that focuses the light from the light source on the particle passing through the flow cell, and forms a second focus that focuses the light from the light source at a position between the detecting lens and photodetector, and disposes the light shielding member at the position of the second focus.07-01-2010
20090174878OPTICAL MEASUREMENT DEVICE - An optical measurement device for measuring an optical appearance of a surface of a sample, in particular the surface of a human skin, wherein the optical measurement device comprises: a first illumination device (07-09-2009
20100020308Transducer Module - Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss. The presented methods for analyzing a blood sample generally include aspirating a whole blood sample into a blood analysis instrument, preparing the blood sample for analysis, passing the blood sample through a flow cell in a transducer system, and measuring axial light loss, multiple angles of light scatter, DC impedance and/or RF conductivity.01-28-2010
20120147357METHOD AND APPARATUS FOR DETECTING AND COUNTING PLATELETS INDIVIDUALLY AND IN AGGREGATE CLUMPS - A method for enumerating platelets within a blood sample is provided. The method includes the steps of: 1) depositing the sample into a sample container having an analysis chamber adapted to quiescently hold the sample for analysis, and an amount of colorant that platelets absorb and which fluoresces upon exposure to one or more predetermined first wavelengths of light; 2) imaging at least a portion of the sample disposed in the analysis chamber, including producing image signals indicative of fluorescent emissions from the platelets illuminated by first wavelengths of light; 3) identifying the platelets using the image signals; and 4) enumerating individual platelets and clumped platelets within the sample using one or more of fluorescent emissions, area, shape, and granularity.06-14-2012
20120008130CORRELATION TECHNIQUE FOR ANALYSIS OF CLINICAL CONDITION - The present invention provides a correlation technique for analysis of changes in bodily fluid and/or tissue in order to identify or monitor appearance, progression or treatment of a disease or condition in a subject. The disclosed method involves measuring spectral properties or changes in bodily fluid and/or tissue of a subject using at least two optical techniques; and correlating the measured properties or changes to a corresponding clinical condition or change in clinical condition, respectively. The measure of spectral changes over time can be used as indicators of changes in the clinical condition, for example, in disease treatment and/or disease regulation. This method is particularly useful for identifying a disease state and for monitoring efficacies of therapies used to treat different diseases or disorders, for example, renal dialysis.01-12-2012
20090015819OPTICAL ANALYSIS SYSTEM, BLOOD ANALYSIS SYSTEM AND METHOD OF DETERMINING AN AMPLITUDE OF A PRINCIPAL COMPONENT - The optical analysis system (01-15-2009
20120206713EXAMINATION DEVICE AND EXAMINATION METHOD - Provided herein are an examination device and an examination method that can efficiently perform examination even when both whole blood and serum/blood plasma specimens are to be examined. A solid-phase extraction cartridge or a filter is placed on a continuous track of a cartridge table. A cup table is disposed below the cartridge table. A cup is placed on a continuous track of the cup table to receive a sample purified by the filter. When viewed from above, the continuous track of the cartridge table and the continuous track of the cup table cross each other at a position “m”, and each of the tracks crosses a position at which a sample probe operates. A pretreatment for serum/blood plasma is completed in one rotation of the cartridge table. A pretreatment for whole blood is completed in two rotations of the cartridge table.08-16-2012
20090135407Microchip - There is provided a microchip that is formed of a first substrate having a surface with a groove and a second substrate joined together and has a fluid circuit in the form of a cavity defined by the groove and a surface of the second substrate closer to the first substrate. The fluid circuit at least includes a detection portion having an optical path for transmitting light. The microchip includes at least one of a step defined by a groove formed in contact with at least one side surface of a groove of the first substrate that defines the optical path and a recess provided in the second substrate at a position opposite to the step.05-28-2009
20110102768METHOD OF DETERMINING GLUCOSE CONCENTRATION OF A WHOLE BLOOD SAMPLE - A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence. The second lens is adapted to receive light from the first lens and adapted to output a substantially collimated beam of light. The detector is adapted to measure the light output by the second lens.05-05-2011
20080266545Sensor board - The invention relates to a sensor board comprising a plate-like body comprising a body material and having two surfaces substantially parallel to each other, and at least one optical sensor and at least one non-optical sensor, the sensors being positioned at the same surface of the body, wherein the body includes a first area having a thickness D10-30-2008
20100245803BLOOD SAMPLE HOLDER FOR SPECTROSCOPIC ANALYSIS - Some embodiments of the invention provide one sample holder that is suitable for collection and spectroscopic measurement of a blood sample. In some very specific embodiments, the sample holder is provided with an optical chamber that is specifically designed to spread blood into a thin film, thereby reducing the average attenuation of electromagnetic radiation (EMR) due to scattering of EMR by the red blood cells in a blood sample, without having to hemolyze the red blood cells. Also, the sample holder is designed so that air bubbles are easily pushed through the optical chamber and guided out of the sample holder through a vent. In some embodiments, the inlet of the sample holder can be reconfigured with adaptors to receive blood from for example, a pin prick or a syringe. Use of adaptors makes the housing simpler when considering the manufacturing process.09-30-2010
20090059202Sample analyzer and sample analyzing method - The present invention is to present a sample analyzer capable of automatically stabilizing the laser diode in multi-mode oscillation. A sample analyzer 03-05-2009
20120170020DEVICE AND METHOD FOR DETECTING BLOOD OR BLOOD CONSTITUENTS IN THE LIQUID SYSTEM OF A DEVICE FOR EXTRACORPOREAL BLOOD TREATMENT - The present invention relates to a device and a method for detecting blood or blood constituents in the liquid system of a device for extracorporeal blood treatment, comprising a dialysis device or filter divided by a semipermeable membrane into a first chamber and a second chamber, wherein the first chamber is part of the extracorporeal blood circulation system and the second chamber part of the liquid system of the extracorporeal blood treatment device. The device according to the present invention for detecting blood or blood constituents in the liquid system of an extracorporeal blood treatment device is designed as a unit for differentiating between the entry of blood into the liquid system due to a defect of the dialysis device or filter, for example a rupture of the semipermeable membrane of the dialysis device or filter, or the entry of hemoglobin into the liquid system due to hemolysis, wherein a differentiation is made between a defect of the dialysis device or filter or hemolysis based on the change in intensity of at least the blue fraction of the light exiting from the liquid.07-05-2012
20120176599OPTICAL TRANSCEIVER - The subject matter disclosed herein relates to an optical emitter-detector for physiological measurements.07-12-2012
20120075616WHOLE BLOOD IMMUNITY MEASURING DEVICE AND WHOLE BLOOD IMMUNITY MEASURING METHOD - A whole blood immunity measuring device includes a hemolytic reagent supply device that supplies a hemolytic reagent to a whole blood sample, a first light source that irradiates light on a first blood sample as being the whole blood sample to which the hemolytic reagent is added, a first light detection device that detects transmitted first light intensity, and a Hgb calculation part that calculates concentration of hemoglobin based on the first light intensity. An immunoreagent supply device supplies an immunoreagent to the first sample, a whole second light source irradiates light on a second blood sample as being the first sample to which the immunoreagent is added. A second light detection device detects transmitted second light intensity, and a measuring object calculation part that calculates a concentration of the measuring object based on the second light intensity.03-29-2012
20110102769Small angle light scattering assay system and method for detecting malaria infection - Differences between a control profile of light scattered by a control sample from a sample of whole blood and a detection profile of light scattered from a detection sample from the sample of whole blood with a detection agent added indicate malaria infection of the whole blood, where the light scattering is Mie scattering by an ensemble of scatterers in samples which are detection optimized to a concentration just low enough so that each scatterer which does scatter light scatters light only once, where the profiles are for light scattered between zero and five degrees.05-05-2011
20120262704Measuring Volume and Constituents of Cells - A method for determining a mean cell volume for a blood sample includes: illuminating the sample with incident light at a plurality of illumination wavelengths and obtaining a two-dimensional image of the sample at each of the plurality of illumination wavelengths; identifying a plurality of cells that appear in each of the images; for each one of the plurality of cells, determining an integrated optical density corresponding to each of the plurality of illumination wavelengths; for each one of the plurality of cells, determining a cell volume based on the integrated optical densities corresponding to each of the plurality of illumination wavelengths; and determining the mean cell volume for the blood sample from the cell volumes for each one of the plurality of cells.10-18-2012
20120262703Measuring Volume and Constituents of Cells - A method of determining a volume of a platelet includes: (a) illuminating the platelet with incident light at a plurality of illumination wavelengths; (b) obtaining at least one two-dimensional image of the platelet corresponding to each illumination wavelength; (c) for each illumination wavelength, determining a mean optical density and a maximum optical density for the platelet; (d) determining an area of the platelet; (e) for each illumination wavelength, determining a volume of the platelet; (f) for each illumination wavelength, determining an integrated optical density for the platelet; and (g) determining the volume of the platelet based on a weighted combination of the area of the platelet, the volumes of the platelet corresponding to each of the illumination wavelengths, and the integrated optical densities for the platelet corresponding to each of the illumination wavelengths.10-18-2012
20120140205METHODS AND SYSTEMS FOR CONTROLLING THE FLOW OF PARTICLES FOR DETECTION - A method of focusing particles is provided. The method includes transiting a fluid containing particles therein through a channel at a flow rate and adjusting the flow rate for a desired transit time through an interrogation zone through which a light from an excitation source passes. The method further includes optically exciting the particles with the excitation source, detecting an optical signal from the particles, and analyzing the optical signal. The particles may be droplets. Further, the particles may transit the interrogation zone in single file. A system of focusing particles is also provided. The system includes a channel having an inlet for accepting a fluid containing particles. The system further includes a flow adjuster configured to adjust the flow rate for a desired transit time through an interrogation zone, a light source configured to optically excite the particles, and a detector configured to detect optical signals from the particles.06-07-2012
20090201490APPARATUS AND METHOD USING LIGHT RETRO-REFLECTED FROM A RETINA TO NON-INVASIVELY MEASURE THE BLOOD CONCENTRATION OF A SUBSTANCE - A method determines the concentration of a substance in a subject's blood. The method includes noninvasively irradiating an eye with a measurement light beam having a first wavelength and a first power and with a reference light beam having a second wavelength and a second power. The second wavelength is different from the first wavelength. The method further includes measuring at least one of a body temperature of the subject and an ambient temperature of the subject. The method further includes detecting a power of the measurement retro-reflected light beam and detecting a power of the reference retro-reflected light beam. The method further includes calculating a measurement ratio of the detected power of the measurement retro-reflected light beam and the first power and calculating a reference ratio of the detected power of the reference retro-reflected light beam and the second power. The method further includes calculating a parameter dependent on the measurement ratio and the reference ratio and determining a concentration of the substance in the subject's blood in response to the calculated parameter and to the at least one of the body temperature and the ambient temperature.08-13-2009
20130100435DEVICE AND METHOD INTENDED TO MEASURE THE PROPERTIES OF A COMPLEX MEDIUM BY ANALYSIS OF THE VARIATION IN BACKSCATTERED AND/OR TRANSMITTED LIGHT - Disclosed is a device and method intended to measure the properties of a complex medium (04-25-2013
20130100434OPTICAL DETECTION APPARATUS AND OPTICAL MEASUREMENT SYSTEM - An optical detection apparatus which is capable of measuring a sample is provided. The optical detection apparatus includes a plurality of light emission units, a light receiving unit, a driving unit, and an analyzing unit. Each of the light emission units is capable of emitting a light beam. The light receiving unit is capable of receiving the light beam passing through the sample and is capable of converting the received light beam to an electrical signal. The driving unit is capable of changing the relative position of the light emission units and the sample. The analyzing unit is electrically connected to the light receiving unit and is capable of measuring a property of the sample by using the electrical signal. A number of the light receiving unit is less than a number of the light emission units. An optical measurement system including the optical detection apparatus is also provided.04-25-2013
20130114068SAMPLE CELL FOR FLUID ANALYSIS SYSTEM - Systems and method are disclosed for determining a concentration of an analyte (e.g., glucose) in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A centrifuge motor can spin the sample cell to separate the fluid into a plurality of components (plasma, red blood cells, etc.). A particular component of the fluid (e.g., plasma) may be positioned at a sample portion of the sample cell after centrifuging such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a cuvette that has two window pieces sandwiched between two clamshell pieces, and where the sample portion of the sample cell is defined by a gap between the window pieces.05-09-2013
20080212071METHOD OF DETERMINING ANALYTE CONCENTRATION IN A SAMPLE USING INFRARED TRANSMISSION DATA - A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.09-04-2008
20080198361Method and Apparatus for Determining Blood Analytes - The present invention provides a method of measuring the concentration of a compound and a value of oxygen saturation in the blood of a part of a subject. Also provided is a device for carrying out the disclosed method. The method relates to measuring the concentration of a compound and a value of oxygen saturation in the blood part of a subject, and correlating the measured concentration of the compound and/or the value of oxygen saturation in the blood to a specific clinical condition. The device comprises a polychromatic light source, a receptor, a detector, and a processing system comprising a calibration algorithm.08-21-2008
20080198360Transmission Spectroscopy System for Use in the Determination of Analytes In Body Fluid - A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence. The second lens is adapted to receive light from the first lens and adapted to output a substantially collimated beam of light. The detector is adapted to measure the light output by the second lens.08-21-2008
20100309454SPECTROMETERS MINIATURIZED FOR WORKING WITH CELLULAR PHONES AND OTHER PORTABLE ELECTRONIC DEVICES - Based on the present invention, superior compact spectrometers may be constructed and integrated into a cellular phone, or attached to a cellular phone. Such a cellular phone may be a PDA phone, which supplies electrical power to the said spectrometer, provided with data storage, signal processing capability, and real-time display. As a combined standalone system, it allows spectroscopic measurements to be fulfilled in real-time applications in field, and results can be sent out in wireless communication to a remote station or to another cellular phone user in order to share the measurement results right away. When the system is used with a laser to function as a Raman spectrometer system, it can fulfill many daily routine tasks encountered by ordinary civilians, for example, the blood glucose monitoring for diabetes patients at home in a non-invasive manner.12-09-2010
20130155387DEVICE FOR DETERMINING AND/OR MONITORING FOREIGN STRUCTURES IN A FLUID OR IN A FLUID STREAM, AND METHOD FOR DOING SAME - The present invention relates to an apparatus for determining and/or monitoring foreign structures in a fluid or in a fluid flow, in particular blood or bloodstream, having at least one optical monitoring means, at least one ultrasound monitoring means and at least one signal evaluation means, wherein the fluid can be optically monitored at least by means of the optical monitoring means and at least by means of ultrasound by means of the ultrasound monitoring means, and wherein at least one foreign structure, can be recognized in the fluid by the signal evaluation means with reference to the combination of the monitoring signals obtained herefrom, in particular with reference to the comparison of the monitoring signals acquired herefrom and/or can be distinguished from at least one second foreign body structure by means of the signal evaluation means.06-20-2013
20080291425Removable sorting cuvette and nozzle - A flow cell and flow cytometer in which a nozzle at the end of a flow channel is disposed on a removable substrate held at a registered location on a flow cell. Other elements including illumination optics, light collection optics, and the flow cell may then be positioned at fixed locations and would not require subsequent periodic adjustment. The registered location for positioning the nozzle allows removal and replacement of the nozzle key with the nozzle subsequently positioned in the identical location.11-27-2008
20130201469Method for Analysis of Pathogenic Microorganisms in Biological Samples Using Raman Spectroscopic Techniques - A system and method for assessing the presence or absence of a pathogenic microorganism in a biological sample. the sample is irradiated to generate interacted photons which are used to generate at least one Raman data set represetnive of the sample. The Raman data set may comprise at least one of: a Raman spectrum and a Raman chemical image. The Raman chemical image may comprise a hyperspectral image. The method may further identify the pathogenic microorganism and associate it with a particular microbiome, such as the digestive system. The method may further associate the sample with a disease state and/or stage.08-08-2013

Patent applications in class BLOOD ANALYSIS

Patent applications in all subclasses BLOOD ANALYSIS