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250458100 - LUMINOPHOR IRRADIATION

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DocumentTitleDate
20130043407Zn5(BTA)6(TDA)2 - A ROBUST HIGHLY INTERPENETRATED METAL-ORGANIC FRAMEWORK CONSTRUCTED FROM PENTANUCLEAR CLUSTERS FOR SELECTIVE SORPTION OF GAS MOLECULES - Disclosed herein are highly interpenetrated robust metal-organic frameworks having the repeat unit Zn02-21-2013
20130043405In-Line Photoluminescence Imaging of Semiconductor Devices - Methods and systems are presented for acquiring photoluminescence images (02-21-2013
20130043406LUMINESCENT COMPOUNDS - A crystalline phosphor of formula:02-21-2013
20090321659METHOD FOR ON-SITE DRUG DETECTION IN ILLICIT DRUG SAMPLES - The invention is intended for illicit drug detection, preferably to Cocaine detection in street samples containing in addition to Cocaine also adulterants and/or diluents (also denominated as cutting agents) used for increasing the quantity of the product and/or for disguising the existence of Cocaine. The invention provides preparing of the liquid street sample, taking an aliquot of said sample, its analysis with help of SFS (Spectral Fluorescence Signatures) technology, fixing the result of analysis as a reference value, the subsequent acidification of the liquid sample, taking an aliquot of the acidified liquid sample and its analysis with help of SFS technology, fixing the result of analysis and comparing said result with the reference value. The result of comparison enables to differentiate between Cocaine Base and Cocaine hydrochloride in the street sample.12-31-2009
20090194707MICROFLUIDIC IMMUNOASSAY DEVICE - An optical fiber for use in an immunoassay device having at least one microfluidic channel, the optical fiber being for transmitting excitation light to the microfluidic channel and for transmitting emitted fluorescence to a light detector.08-06-2009
20130075626OPTICAL SYSTEM - An optical system includes a sample carrier receiving region configured to receive a carrier carrying a sample for processing, a source that emits an excitation signal having a wavelength within a first predetermined wavelength range, and a first set of optical components that direct the excitation signal along an excitation path to the sample carrier receiving region, wherein radiation having a wavelength within a second predetermined wavelength range is emitted from the sample carrier receiving region in response to receiving the excitation signal. The system further includes a detector configured to detect the emitted radiation and generates a signal indicative of a power of the detected radiation and a second set of optical components that directs the emitted radiation along a collection path to the detector and a power meter that measures a power of the radiation emitted from the sample carrier receiving region and generates a signal indicative thereof.03-28-2013
20130075627APPLYING EDGE-ON PHOTOLUMINESCENCE TO MEASURE BULK IMPURITIES OF SEMICONDUCTOR MATERIALS - Provided are photoluminescence spectroscopy systems and methods for identifying and quantifying impurities in a semiconductor sample. In some embodiments, the systems and methods comprise a defocused collimated laser beam illuminating a first sample surface, and collection by a collection lens of photoluminescence from a sample edge at the intersection of the first surface with a substantially orthogonal second surface, wherein the first sample surface is oriented from about 0° to 90° with respect to a position parallel to the collection lens.03-28-2013
20100148092MICROARRAY READER BASED ON EVANESCENT WAVE DETECTION AND METHOD OF READING A MICROARRAY - A microarray reader (06-17-2010
20110192992SCANNER PHOTOMETER METHODS - A scanning photometer and attendant methods are provided. The scanning photometer is generally characterized by first and second fluorophore excitation sources, an objective lens, and a common emission detector for the detection of first and second fluorophore emission originating from the excitation of the fluorophores via passage of excitation energy, via an optical path of the objective lens, from the excitation sources. Excitation energy and emission energy conditioning elements are like-wise provided, operatively interposed before or after the objective lens as the case may be.08-11-2011
20110192991MICROPARTICLE ANALYSIS DEVICE AND MICROPARTICLE ANALYSIS METHOD - Disclosed herein is a microparticle analysis device including: a light source configured to irradiate a microparticle with light; an acousto-optic modulator configured to diffract fluorescence generated from the microparticle due to the light irradiation; a slit configured to allow transmission of only diffracted light in a diffraction center wavelength region among diffracted light beams from the acousto-optic modulator; and a detector configured to detect the diffracted light in the diffraction center wavelength region transmitted through the slit.08-11-2011
20130037729Determining the Distribution of a Substance by Scanning with a Measuring Front - For determining the distribution of a substance, a measuring front is formed of a first and a second optical signal. Intensities of the first and second optical signals, over a depth of the measuring front which is smaller than the diffraction limit at the wavelengths of the first and second optical signals, increase so steeply that a portion of the substance in a measurement state in which a measurement signal is available from the substance increases from essentially zero due to transferring the substance by means of the first optical signal into the measurement state, and decreases to essentially zero again due to transferring the substance by means of the second optical signal back out of the measurement state. The measuring front is moved over a measurement region. The measurement signal is recorded for different positions of the measuring front in the measurement region and assigned to these positions.02-14-2013
20130037728PARTICLE ANALYZER WITH SPATIAL MODULATION AND LONG LIFETIME BIOPROBES - An analyzer includes a flow cell having a flow channel through which a sample passes. A light source excites at least a first particle type in the sample in one or more excitation region(s), and a detector detects light emitted by the excited particle. A spatial filter defines detection regions, wherein light emitted by the particle is transmitted to the detector, and interspersed shielded regions, wherein such light is at least partially blocked from reaching the detector. The light emitted by the excited particle has a response time τ02-14-2013
20100072397SUB WAVELENGTH APERTURE - There is provided a method of detecting a presence of a luminophore in a detection volume comprising providing excitation radiation in said detection volume. A luminophore is provided in said detection volume being excitable by said excitation radiation. The luminescent radiation is detected to identify the presence of said luminophore in said detection volume. In one aspect of the invention, said luminophore is selected to emit luminescent radiation having a wavelength in said medium that is larger than twice said smallest dimension; and wherein said luminophore is selected to be excitable by excitation radiation having a wavelength in said medium that is smaller than twice said smallest dimension. Accordingly, luminescent radiation is blocked from entering the detector but for the portion present on an interface of the aperture.03-25-2010
20100072396CONCURRENT MONITORING OF A PLURALITY OF SAMPLES BY AN ARRAY OF BIOSENSING ELEMENTS - A system and method are presented for monitoring detectable responses from multiple biosensing elements while in contact with multiple samples located in an array. The system (03-25-2010
20090236543Fluorescence Detection Using Lyman-alpha Line Illumination - A method and system is provided that takes advantage of the atmospheric transmission properties of the Hydrogen Lyman-α radiation line (121.6 nm wavelength) to illuminate a sample with high energy VUV photons at least partially in an atmospheric environment. Thus, according to the principles of the present invention, a sample is illuminated by radiation at the Hydrogen Lyman-α radiation line (121.6 nm wavelength), at least partially in an atmospheric environment, and luminescent radiation from the sample at longer wavelengths is detected. The high energy illuminating photons generate luminescent radiation from the sample at longer wavelengths, typically in the visible wavelength range, and this radiation can then be imaged, e.g. with a normal visible microscope.09-24-2009
20120025099SYSTEMS AND METHODS FOR SPECTRALLY ENCODED IMAGING - A method of forming an image of a target that comprises illuminating a target with light, maneuvering an optical unit having at least one diffractive element in front of the target through a plurality of positions, capturing, during the maneuvering, a plurality of spectrally encoded frames each from a portion of the light that is scattered from a different of a plurality of overlapping segments along a track traversing an image plane of the target, and combining the plurality of spectrally encoded frames to form a composite multispectral image of at least a portion of said target.02-02-2012
20100044586FAST THERMO-OPTICAL PARTICLE CHARACTERISATION - The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).02-25-2010
20100044584CARBON NANOTUBE CONTAINING MATERIALS AND ARTICLES CONTAINING SUCH MATERIALS FOR ALTERING ELECTROMAGNETIC RADIATION - Disclosed herein is a material for altering electromagnetic radiation incident on the material. The material disclosed herein comprises carbon nanotubes having a length (L) that meets the following formula (1):02-25-2010
20100044585BIOSENSOR USING WIRE-GRIDS FOR INCREASING CAVITY ENERGY - The invention discloses a luminescence sensor (02-25-2010
20100102249METHOD OF LUMINESCENT SOLID STATE DOSIMETRY OF MIXED RADIATIONS - A method of determining the doses of neutrons, gamma and X-ray photons, beta, alpha and other ionizing radiations using a method of image processing in spatial and frequency domain that produces parameters that are related to the radiation dose absorbed in a luminescent material. Portions of the luminescent material may be covered by different converters to allow for doses of different radiations to be discriminated.04-29-2010
20090159815FLUORESCENCE OBSERVATION OR FLUORESCENCE MEASURING SYSTEM AND METHOD - The fluorescence observation or fluorescence photometry system uses an optical base material having low autofluorescence and good adhesive property to cell. Said optical base material has the following optical characteristics:06-25-2009
20100108910PATHOGEN AND PARTICLE DETECTOR SYSTEM AND METHOD - The system includes an excitation source for providing a beam of electromagnetic radiation having a source wavelength. A first wavelength selective device is positioned to be impinged by the beam of electromagnetic radiation. The first wavelength selective device is constructed to transmit at least a portion of any radiation having the source wavelength and to reflect radiation of other wavelengths. A medium containing particles is positioned to be impinged by the beam of electromagnetic radiation. At least a portion of the beam of electromagnetic radiation becomes scattered within the medium, the scattered electromagnetic radiation including forward scattered electromagnetic radiation and backward scattered electromagnetic radiation. An optical detector is positioned to receive backward and/or forward scattered electromagnetic radiation.05-06-2010
20130026391INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, PROGRAM, AND METHOD OF CORRECTING INTENSITY OF FLUORESCENCE SPECTRUM - Provided is an information processing apparatus including an estimation unit that expresses a light intensity distribution, which is obtained by irradiating light to a measurement object of a measurement target having a plurality of substances with mutually different responsive characteristics to the light on a surface and/or an inside of the measurement object, as a linear combination of light intensity distributions, which are obtained by irradiating the light to reference measurement objects, each of which has a single substance, models the light intensity distribution obtained from each of the reference measurement objects so as to follow a predetermined probability distribution, and estimates a combination coefficient of the linear combination from the light intensity distribution obtained from the measurement object of the measurement target.01-31-2013
20090134342High spatial resolution imaging of a structure of interest in a specimen - For the high spatial resolution imaging of a structure of interest in a specimen, a substance is selected from a group of substances which have a fluorescent first state and a nonfluorescent second state; which can be converted fractionally from their first state into their second state by light which excites them into fluorescence, and which return from their second state into their first state; the specimen's structure of interest is imaged onto a sensor array, a spatial resolution limit of the imaging being greater (i.e. worse) than an average spacing between closest neighboring molecules of the substance in the specimen; the specimen is exposed to light in a region which has dimensions larger than the spatial resolution limit, fractions of the substance alternately being excited by the light to emit fluorescent light and converted into their second state, and at least 10% of the molecules of the substance that are respectively in the first state lying at a distance from their closest neighboring molecules in the first state which is greater than the spatial resolution limit; and the fluorescent light, which is spontaneously emitted by the substance from the region, is registered in a plurality of images recorded by the sensor array during continued exposure of the specimen to the light.05-28-2009
20130082191STRESS-SENSITIVE MATERIAL AND METHODS FOR USING SAME - A stress-sensing material containing a matrix material and a photo-luminescent particle is disclosed, together with adhesives and coatings containing the stress-sensing material. Also disclosed are methods for preparing the stress-sensing material and measuring the stress on an article using the stress-sensing material.04-04-2013
20130087719LIGHT SOURCE DEVICE FOR TIME-DELAYED DETECTION OF FLUORESCENCE, AND IMAGE PICK-UP SYSTEM AND METHOD - The present invention discloses a light source device, image pick-up system and pick-up method for time-delayed detection of fluorescence, essentially applying a pulsed-excitation light source installed inside a light source device in conjunction with a shutter to pick up a photoluminescence image of an object located at a predetermined detection site, the light source device comprising: a pulsed-excitation light source for emitting light towards the predetermined detection site; and a controller for instructing the pulsed-excitation light source to emit light, the controller being connected in feedback signals to the shutter, thereby closing the shutter when the pulsed-excitation light source emits light and opening the shutter as soon as the light pulse terminates in order to effectively shield reflection light and diffusive reflection light to purely capture the photoluminescence data.04-11-2013
20120181452SEPARATION OF DOPING DENSITY AND MINORITY CARRIER LIFETIME IN PHOTOLUMINESCENCE MEASUREMENTS ON SEMICONDUCTOR MATERIALS - Methods are presented for separating the effects of background doping density and effective minority carrier lifetime on photoluminescence (PL) generated from semiconductor materials. In one embodiment the background doping density is measured by another technique, enabling PL measurements to be analysed in terms of effective minority carrier lifetime. In another embodiment the effective lifetime is measured by another technique, enabling PL measurements to be analysed in terms of background doping density. In yet another embodiment, the effect of background doping density is removed by calculating intensity ratios of two PL measurements obtained in different spectral regions, or generated by different excitation wavelengths. The methods are particularly useful for bulk samples such as bricks or ingots of silicon, where information can be obtained over a much wider range of bulk lifetime values than is possible with thin, surface-limited samples such as silicon wafers. The methods may find application in solar cell manufacturing for improving the manufacture of silicon ingots and bricks, or for providing a cutting guide for wafering.07-19-2012
20120181450METHOD AND APPARATUS FOR DETECTING BIO MATERIAL USING PHOTOELECTRIC CONVERSION DEVICE, AND METHOD FOR MANUFACTURING PHOTOELECTRIC CONVERSION DEVICE - An apparatus for detecting a bio material includes: an conjugate of a bio material and a fluorescent material to be excited and emit light of a lower energy than an energy of incident light by virtue of the fluorescent material when the light is incident; and an optical filter for allowing the excitation-emitted light from the conjugate, among the incident light, to be transmitted therethrough. The apparatus further includes a photoelectric conversion device for converting the light transmitted through the optical filter into an electric signal.07-19-2012
20120181449SYSTEM AND METHOD FOR VERIFYING CORRECT ORDERING OF STACK OF COMPONENTS - A method of determining whether a stack of components in a device are in a desired order includes irradiating each of the components in the device with an energy beam. The radiation emissions from each of the irradiated components are detected with a radiation detector. The detected radiation emissions are analyzed using a central processing unit (CPU) to determine whether the components in the device are stacked in the desired order.07-19-2012
20100006773Method and apparatus for measuring the phase shift induced in a light signal by a sample - A first light source emits a light signal along a measurement optical path that includes a sample and a second light source emits a light signal along a dummy measurement optical path. A measurement circuit receives the light signals and provides outputs separated in time which are indicative of the phase of the respective light signals. A phase shift is induced in light in the measurement optical path by the sample. A reference circuit receives a signal indicative of the phase of the light signals emitted by the first and second light sources. Circuitry compares the phases of light output from the two circuits to provide output indicative of a first measured phase difference during operation of the first light source. Correction is applied to this measurement by taking a similar phase difference measurement during operation of the second light source and comparing the two phase differences.01-14-2010
20100006772METHOD AND APPARATUS FOR HIGH-RESOLUTION OPTICAL SCANNING OF A SAMPLE - A method and an apparatus are suggested for high-resolution optical scanning, particularly in a laser scanning fluorescence microscope. A sample to be scanned comprises a first and a second substance that are switchable into a first and second energy state. In the scanning process, excitation, de-excitation and detection for the first substance is carried out at a different point in time than for the second substance. This achieves a high spatial resolution beyond the diffraction limit while at the same time a high level of information is provided with physically simple and economical means.01-14-2010
20130048875OPTICAL ANALYSIS DEVICE, OPTICAL ANALYSIS METHOD AND COMPUTER PROGRAM FOR OPTICAL ANALYSIS - The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region); generates time series light intensity data, and after smoothing the time series light intensity data; and detects in the smoothed time series light intensity data the light-emitting particle crossing the inside of the micro region individually, thereby enabling the counting of the light-emitting particle(s) or the acquisition of the information on the concentration or number density of the light-emitting particle.02-28-2013
20120217416BANKNOTE VALIDATOR - The present invention relates to the technical field of devices for reading/authenticating banknotes. The invention also concerns handheld devices, particularly those which may be used by visually impaired persons, to identify different banknote denominations. The present invention is aimed at providing a banknote validator that avoids the drawbacks of the prior art. The validator according to the invention may as well be used for validating a security document including a marking (like luminescent ink or pattern printed on said document, luminescent security thread or strip, for example) operable to glow with a specific color luminescence under appropriate UV light illumination. The invention further describes a method for identifying a denomination of a banknote having a test zone including a marking operable to glow with a specific color luminescence according to the denomination under appropriate UV light illumination.08-30-2012
20110006218NANODIAMOND COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF - Provided are functionalized nanodiamonds. Also provided are methods for fabricating such functionalized nanodiamonds. Also provided are composites including nanodiamonds and polymers. Also provided are methods for fabricating such composites including nanodiamonds and polymers. Also provided are electrospun fibers including nanodiamonds and polymers. Also provided are methods for fabricating such electrospun fibers including nanodiamonds and polymers.01-13-2011
20080265176COMPOSITION, METHOD OF AUTHENTICATING, METHODS OF MAKING AUTHENTICATABLE COMPOSITIONS, AUTHENTICATABLE ARTICLES MADE THERE FROM - A composition comprising compound of formula I, a process for preparing the composition comprising compound of formula I, methods of authentication for an article comprising compound of formula I or compound of formula II, authentication technology for polymer based articles comprising compound of formula I or formula II, methods of facilitating such authentication and method of making articles capable of authentication.10-30-2008
20080283771SYSTEM AND METHOD OF COMBINING ULTRASOUND IMAGE ACQUISITION WITH FLUOROSCOPIC IMAGE ACQUISITION - A system and method to image an imaged subject is provided. The system comprises an ultrasound imaging system including an imaging probe operable to move internally and acquire ultrasound image data of the imaged subject, a fluoroscopic imaging system operable to acquire fluoroscopic image data of the imaged subject during image acquisition by the ultrasound imaging system, and a controller in communication with the ultrasound imaging system and the fluoroscopic imaging system. A display can be illustrative of the ultrasound image data acquired with the imaging probe in combination with a fluoroscopic imaging data acquired by the fluoroscopic imaging system.11-20-2008
20120112098ENHANCING VISUAL ASSESSMENT OF SAMPLES - Methods and systems for imaging a biological sample are disclosed, and include: (a) staining the sample with a first stain that includes eosin and at least one additional stain; (b) directing excitation light to the sample to cause each of the stains to emit fluorescence; and (c) recording images of the fluorescence emitted from the stains in the sample, where the amount of eosin in the sample is sufficiently dilute to cause the sample to have an average optical density of less than 0.10 at green wavelengths.05-10-2012
20120112097METHOD AND APPARATUS FOR QUANTITATIVE ANALYSIS OF THE EXTENT OF MEMBRANE FOULING BY USING FLUORESCENT PROTEIN STRUCTURES - Disclosed are a method and an apparatus for quantitative analysis of the extent of separation membrane fouling using a fluorescent protein structure, allowing easy quantitative analysis of the extent of separation membrane fouling and improving accuracy thereof. The disclosed method for quantitative analysis of the extent of separation membrane fouling using a fluorescent protein structure includes: preparing a solution containing a fluorescent protein structure; passing the solution containing the fluorescent protein structure through a separation membrane so as to adsorb the fluorescent protein structure onto the separation membrane; and quantitatively analyzing the fluorescent protein structure adsorbed onto the separation membrane by measuring fluorescence emitted by the fluorescent protein structure adsorbed to the separation membrane.05-10-2012
20120112096SYSTEM AND METHOD FOR DETERMINING THREE-DIMENSIONAL INFORMATION FROM PHOTOEMISSION INTENSITY DATA - A method and system for investigating properties of an object comprising: a transmitter, including a radiation source, the transmitter providing incident radiation having a plurality of predetermined polarization states; the incident radiation illuminating an object and thereby causing the object to emit photoemission; a receiver, receiving photoemission from the object when the object is illuminated by the incident radiation, the receiver including a detector, the detector providing photoemission intensity data; and signal processing circuitry, in electrical communication with the detector, the signal processing circuitry determining three-dimensional information relating to the object from the photoemission intensity data for each of the plurality of incident polarization states.05-10-2012
20120112095HIGH RESOLUTION MICROSCOPY USING AN OPTICALLY SWITCHABLE FLUOROPHORE - The invention relates to a method for high resolution visualization of a compound that can be switched by a switching signal from a state of low fluorescence to a state of higher fluorescence, and then revert to the state of low fluorescence. Said switching signal is directed to a spot in a region of a material containing said compound, and an optical signal adapted to lower the probability that said switching signal will successfully switch said compound to said state of higher fluorescence is directed to said spot and shaped to have a minimum in said spot, such that the probability that said switching signal successfully switches said compound is greatest at said minimum. Said spot containing both said switching signal and said optical signal is scanned over said region of said material while monitoring the fluorescence from said compound in said spot to create an image of said region. In some embodiments of the invention a plurality of spots are simultaneously scanned, to reduce the imaging time.05-10-2012
20090289201COMBINED VISUAL/FLUORESCENCE ANALYTE DETECTION TEST - The sensitivity of visually read lateral flow immunoassay tests is enhanced by adding a small quantity of fluorescing dye or fluorescing latex bead conjugates to the initial conjugate material. When the visible spectrum test line is visibly present, the test result is observed and recorded. However, in the case where the result is indeterminate, a light of an appropriate spectrum, such as a UV, visible, or infrared spectrum, is cast on the test line to excite and fluoresce the fluorescing latex beads which are bound in the test line in true positive tests to enhance the visible color at the test line.11-26-2009
20130062537COMBINATION OF LUMINESCENT SUBSTANCES - The invention relates to a luminescent composition comprising a component which can be excited by infrared (IR) radiation and a component which can be excited by ultraviolet (UV) radiation. The composition has a characteristic emission spectrum and may optionally be used together with a reading system adapted to the emission spectrum in order to mark substances or mixtures of substances.03-14-2013
20130062536Illumination Systems and Methods for Photoluminescence Imaging of Photovoltaic Cells and Wafers - Methods are presented for analysing semiconductor materials (03-14-2013
20120223251Analyte Detector and Method - Instrument and method for detecting pesticides and other analytes. A sample to be tested is mounted on a cassette and inserted into a housing which is substantially impervious to light, and light from a source within the housing is directed toward the sample to induce fluorescent emission from analyte on the sample. Fluorescent emissions from the sample are monitored with a detector within the housing to detect emissions having a spectral content characteristic of the analyte to be detected. Data from the detector is processed, and information based on the processed data is displayed. In some embodiments, the instrument is calibrated with data from a reference sample of known concentration or density. The detector measures the analyte in units of mass per unit area, and in some embodiments the mass per unit area is converted to units of concentration or density of the analyte in the sample.09-06-2012
20110012027OPTICAL LUMINESCENCE OF FUNCTIONALIZED FULLERENES IN AN OXYGEN FREE ENVIRONMENT - Functionalized fullerenes, when excited at any of a broad range of wavelengths in an oxygen free environment, undergo luminescence. The oxygen sensitive luminescence of functionalized fullerenes is used for numerous applications including oxygen detection; irradiation induced healing of polymeric materials; and phosphors for optical location and display applications. The degradation of the functionalized fullerenes allows for the detection of oxygen by diminished luminescence when the fullerenes are exposed to an irradiation source, such as a laser beam, in the presence of oxygen. The luminescence from a portion of a surface of a material with functionalized fullerenes allows for the location of the surface containing a functionalized fullerene target in the absence of oxygen or to heat the object in the area irradiated that is exposed to oxygen. The localized heating can be used to repair defects to a material containing the functionalized fullerenes. Materials containing functionalized fullerenes can be used as phosphors in display applications.01-20-2011
20110036994APPARATUS AND METHOD - An apparatus for investigating a molecule comprising a channel provided in a substrate, a metallic moiety capable of plasmon resonance which is associated with the channel in a position suitable for the electromagnetic field produced by the metallic moiety to interact with a molecule passing therethrough, means to induce a molecule to pass through the channel, means to induce surface plasmon resonance in the metallic moiety; and means to detect interaction between the electromagnetic field produced by the metallic moiety and a molecule passing through the channel. Methods of investigating molecules are also provided.02-17-2011
20090261270Monitoring Cleaning of Surfaces - A method for monitoring cleaning of a surface includes applying an amount of transparent indicator material to an area of a surface and measuring the amount of transparent indicator material remaining on the surface. The transparent indicator material may be fixed on the surface by drying and, when a fluorescent material, may be measured through exposure to ultraviolet radiation.10-22-2009
20130161536MICROORGANISM DETECTING APPARATUS CALIBRATION METHOD AND MICROORGANISM DETECTING APPARATUS CALIBRATION KIT - A method for calibrating a microorganism detecting apparatus including drawing, into a microorganism detecting apparatus, polystyrene particles that, when exposed to light produce fluorescence of essentially the same intensity as the intensity of fluorescence produced by microorganisms; exposing the polystyrene particles to light from a light source of the microorganism detecting apparatus and detecting, using a fluorescence detector of the microorganism detecting apparatus, the fluorescence produced from the polystyrene particles; and calibrating the microorganism detecting apparatus based on the intensity of the detected fluorescence.06-27-2013
20090236542OPTICAL INSPECTION - This invention relates to methods of determining physical characteristics of and identifying and locating defects in substrates, such as semiconductor wafers, optical thin films, display screens and the like. The method involve use of PC scanners to image the substrate. In particular PC scanners used in transmission mode imaging allow information about the volume of the substrate to be determined. The method allows determination of characteristics such as layer thickness, curvature and optical constants through use of interferometery techniques and bifrefringence and strain through use of polarised imaging. The methods also relate to stimulating luminescence in the substrate, for example photoluminescence and electroluminescence and scanning the stimulated substrate for luminescence mapping.09-24-2009
20130068967Method for Generating a Microscope Image and Microscope - The invention relates to a method and a microscope for generating a microscopic image, wherein 03-21-2013
20130214176Spatially Correlated Light Collection from Multiple Sample Streams Excited with a Line Focused Light Source - An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector.08-22-2013
20130214177METHOD OF CALIBRATING AND CORRECTING COLOR-BLEED FACTORS FOR COLOR SEPARATION IN DNA ANALYSIS - A method includes calibrating color bleed factors of optical detector channels of a sample processing apparatus through processing a color bleed calibration substance which includes a plurality of different size fragments replicated from different groups of DNA loci, wherein fragments in a same group are labeled with a same fluorescent dye, and fragments in different groups are labeled with different fluorescent dyes having different emission spectra, wherein the different size fragments are processed during different acquisition times.08-22-2013
20130214178SURFACE COATING FOR INSPECTION - A method of inspecting an article includes: applying an organic liquid substance over at least a portion of the article to be inspected so as to form a surface layer thereon, wherein said surface layer is luminescent; irradiating the article with the surface layer thereon; and scanning the article to determine its shape.08-22-2013
20090008573LIGHT EMITTING DIODE ILLUMINATION SYSTEM - In various embodiments of the invention, a unique construction for Light Emitting Diodes (LEDs) with prisms and dyes and other optical elements can be used to generate a variety of light sources with different emission spectra. In an embodiment of the invention, reflected light can be redirected outward. In another embodiment of the invention, a white LED based light uses a blue LED and associated optics elements, including a high index glass prism or rod, a layer of dyed florescent polymer and an extraction-enhancing optical element or lens, such that all of the light emitted from with the dye layer can be directed outward.01-08-2009
20090256083Zirconium Dioxide Luminescence Oxygen Sensor - A method of measuring oxygen partial pressure in gases, such as hot engine exhaust gases, uses a calibrated luminescence sensor and comprises the steps of bringing nanocrystalline zirconinum dioxide ZrO10-15-2009
20090173889Fluorescent photopolymerizable resins and uses thereof - There is provided fluorescent photopolymerizable resins for use in biological studies and image acquisition. In particular the photopolymerizable resins are useful in studying the properties of cells. The resins are also useful for the calibration of microscopic measurement systems.07-09-2009
20120235061LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.09-20-2012
20110278475MULTIPLEX ILLUMINATION SYSTEM AND METHOD - Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high density optical systems to illuminate high density sample arrays and/or provide detection from such high density arrays. Systems and methods comprise substrates having an array of discrete signal sources having a pitch P11-17-2011
20110278474Axial Illumination for Capillary Electrophoresis - System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.11-17-2011
20110278473METHOD FOR MAKING SECURITY LASER PRINTING FILM - A laser markable security laser transfer film includes a carrier web formed from a laser light-transmissive material and a taggant-containing film disposed on the carrier web. The taggant-containing film is formulated from an energy sensitive taggant capable of withstanding temperatures of at least about 11-17-2011
20110278471FLUORESCENCE DETECTING DEVICE AND FLUORESCENCE DETECTING METHOD - In order to remove autofluorescence emitted by a measurement object, fluorescence of the measurement object within a first wavelength band is first received. The first wavelength band is set so that the intensity of fluorescence emitted by the measurement object irradiated with intensity-modulated laser light is higher than that of autofluorescence emitted by the measurement object irradiated with the laser light. Then, the autofluorescence within a second wavelength band different from the first wavelength band is received. A generated fluorescent signal of the first fluorescence and a generated fluorescent signal of the autofluorescence are mixed with a modulation signal for modulating the laser light to produce first fluorescence data and autofluorescence data, respectively. The autofluorescence data is multiplied by a predetermined constant, and the thus obtained result is subtracted from the first fluorescence data to produce third fluorescence data. The third fluorescence data is used to calculate a fluorescence intensity.11-17-2011
20110278470HIGH DYNAMIC RANGE SCANNING WITH REDUCED CHANNEL CROSS-TALK - A multi-channel scanning system adapted to implement a low channel cross-talk, extra-wide dynamic range scanning method by scanning the same location more than once, wherein at least one time, the power of the excitation light and detector gain are set to High for at least one of the channels and Low for at least one of the other channels and different settings are used in subsequent scans. The scans of the same channel taken with different High and Low settings are merged together to produce one wider dynamic range image.11-17-2011
20110278472OPTICAL DETECTION UTILIZING CARTRIDGE WITH TUNABLE FILTER ASSEMBLY - A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges is a wavelength-tunable cartridge in which different light sources, excitation filters, and/or emission filters may be selected. Tuning is further accomplished by tilting the excitation or emission filters at desired angles relative to a beam of exciting light or emitted light.11-17-2011
20110133101MODULAR IMAGING SYSTEM, MODULES FOR THIS SYSTEM AND METHOD IMPLEMENTED USING THIS SYSTEM - An imaging device including an illumination module including at least one emitter for emitting at least one excitation beam, a scanning and injection module including an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers, and a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide, and a detection module including at least one detector for detecting at least one luminous flux collected at the distal end of the image guide. At least one of the illumination module and the detection module is optically conjugated with the scanning and injection module by a conjugating optical fiber.06-09-2011
20110108738DOPED LUMINESCENT MATERIALS AND PARTICLE DISCRIMINATION USING SAME - Doped luminescent materials are provided for converting excited triplet states to radiative hybrid states. The doped materials may be used to conduct pulse shape discrimination (PSD) using luminescence generated by harvested excited triplet states. The doped materials may also be used to detect particles using spectral shape discrimination (SSD).05-12-2011
20110127446NANOSTRUCTURE SYSTEMS AND METHODS FOR SENSING AN ANALYTE - A method of detecting an analyte in an environment, includes immobilizing at least one photoactive composition on nanostructures, the photoactive composition exhibiting emission that is sensitive to the analyte; applying electromagnetic radiation to the immobilized photoactive moiety for a period of time; measuring at least one response; and using the measured response to determine the presence the analyte in the environment. The nanostructures can, for example, include carbon nanostructures. In a number of embodiments, the analyte is oxygen.06-02-2011
20110284768FLUORESCENCE ANALYZING DEVICE AND FLUORESCENCE ANALYZING METHOD - The present invention has an object to provide a method for efficiently detecting an image with a smaller number of pixels.11-24-2011
20100006774DETECTION METHOD, DETECTION APPARATUS, AND SAMPLE CELL AND KIT FOR DETECTION - A sensor chip including a sensor portion that has at least a metal layer deposited on a surface of a dielectric plate is used. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection target substance in a liquid sample binds onto the sensor-portion. The amount of the detection target substance is detected based on the amount of light generated by excitation of a fluorescent label in the fluorescent-label binding substance. An electrified fluorescent substance containing a plurality of fluorescent dye molecules enclosed by a material that transmits fluorescence output from the plurality of fluorescent dye molecules is used as the fluorescent label. The electrified fluorescent substance is attracted to the sensor portion by applying voltage to the liquid sample in a state in which the fluorescent-label binding substance has bound to the sensor portion. In this state, the amount of the detection target substance is detected.01-14-2010
20110121204TOTAL REFLECTION FLUORESCENCE OBSERVATION DEVICE - A technique and device for fluorescence observation with good operability, high sensitivity, acid high reliability. The device is used for fluorescence observation using evanescent light. The angle of incidence of the excitation light is adjusted so that the excitation light is always totally reflected from the surface of a substrate irrespective of the angle of the surface of the substrate. The method includes a step of shining the excitation light on the observation substrate while continuously varying the angle of the excitation light with respect to the observation substrate, a step of sensing the shone excitation light by means of optical sensors, and a step of setting the angle of total reflection according to the result of the sensing by the optical sensors. The direction in which the shone excitation light travels varies with the angle of incidence. That is, the excitation light travels as the transmitted light, the reflected light, or the surface propagating light. These lights are sensed by the corresponding optical sensors, and how the angle of incidence of the excitation light is with respect to the critical angle is determined. The angle of incidence of the excitation light is varied depending on the result of the determination, thereby realizing an optimum total reflection angle.05-26-2011
20110284769TOTAL INTERNAL REFLECTION MICROSCOPE APPARATUS AND METHOD FOR ANALYZING FLUORESCENT SAMPLE - An object of the present invention relates to observation of single molecule fluorescence while temperature of a sample solution is controlled by a temperature controller and intrinsic fluorescence of the temperature controller is avoided, in a total internal reflection microscope. The present invention relates to provision of an opening at areas of the temperature controller through which incident light and reflected light pass, and configuration adopting a material with intrinsic fluorescence lower than that of the other parts, in a total internal reflection microscope including a prism and the temperature controller. The present invention enables intrinsic fluorescence of the temperature controller to be suppressed, which allows highly sensitive fluorescence observation while controlling sample solution temperature with high precision. For instance, this in turn allows the throughput of single molecule DNA sequencing using a total internal reflection microscope to be improved.11-24-2011
20110284770FLUORESCENCE DETECTING DEVICE AND FLUORESCENCE DETECTING METHOD - A fluorescence detecting device generates a modulation signal for modulating an intensity of laser light and modulates the laser light by using the modulation signal, when receiving fluorescence emitted by a measurement object irradiated with laser light emitted from a laser light source unit. The fluorescence detecting device obtains a fluorescent signal of the fluorescence emitted by the measurement object irradiated with the laser light and calculates, from the fluorescent signal, the phase delay of the fluorescence with respect to the modulation signal. At the time, the fluorescence detecting device controls the frequency of the modulation signal so that the value of the phase delay comes close to a preset value. The fluorescence detecting device calculates the fluorescence relaxation time of the fluorescence emitted by the measurement object by using a phase delay obtained under the condition of frequency of the modulation signal at the time when the control is settled.11-24-2011
20110284767COMBINATION MICROSCOPY - A method for generating an image of a sample by a microscopy method including varying local resolution, wherein at least two of the following microscopy methods are combined: laser scanning microscopy, a microscopy method wherein the sample is excited to luminescence by structured line or wide area illumination, and a first microscopy image is generated from the images thus obtained, having increased local resolution greater than the optical resolution of the image, a further microscopy method according to the PAL principle, by which a second microscopy image is generated, indicating geometric locations of marker molecules emitting luminescent radiation at an increased local resolution relative to the optical resolution, and a further microscopy method, wherein the sample is marked using marking molecules suitable for the STED, ESA, or RESOLFT technique, and a third microscopy image is generated of STED, ESA, or RESOLFT, wherein the obtained images are superimposed.11-24-2011
20110297847Fluorescence Microscopy Methods and Apparatus - Methods and apparatus are provided concerning the control of photobleaching of fluorescent labels during the study of samples by fluorescence microscopy. A method is described for operating fluorescence microscopy apparatus to analyse a sample (12-08-2011
20110297848NON-INVASIVE METHODS AND APPARATUS FOR DETECTING INSECT-INDUCED DAMAGE IN A PLANT - Lesions caused by insects feeding on plants are associated with the generation of regions of blue-green fluorescence in such as the cotton boll carpel wall and in the lint region. The present disclosure now provides methods and devices to rapidly and non-invasively detect and measure the insect-related fluorescence and relate the fluorescence generated to the likelihood of insect damage in a crop. In particular, the methods are related to stink bug damage in the cotton plant, but are also suitable for the detection of insect-related damage of any plant. The methods of detecting insect-induced damage in a target plant tissue may comprise exposing a target plant or a fragment thereof, to an ultraviolet or violet light; and detecting an ultraviolet light-induced fluorescence from the target plant or the fragment thereof, thereby indicating the presence of insect-related plant damage. Further provided are devices configured for the identification of insect-induced damage in a plant or a fragment thereof, comprising: a source of an ultraviolet or violet light, at least one light detector; an electronic system for converting an output electrical signal to a measurement of the intensity of fluorescent light detected by the detector; and an output system to convert the measurement of the intensity of the fluorescent light to an indicator for indicating that a target plant or fragment thereof has insect-induced damage.12-08-2011
20110297846ELECTRON INJECTION NANOSTRUCTURED SEMICONDUCTOR MATERIAL ANODE ELECTROLUMINESCENCE METHOD AND DEVICE - Embodiments of the invention include methods and devices for producing light by injecting electrons from field emission cathode across a gap into nanostructured semiconductor materials, electrons issue from a separate field emitter cathode and are accelerated by a voltage across a gap towards the surface of the nanostructured material that forms part of the anode. At the nanostructure material, the electrons undergo electron-hole (e-h) recombination resulting in electroluminescent (EL) emission. In a preferred embodiment lighting device, a vacuum enclosure houses a field emitter cathode. The vacuum enclosure also houses an anode that is separated by a gap from said cathode and disposed to receive electrons emitted from the cathode. The anode includes semiconductor light emitting nano structures that accept injection of electrons from the cathode and generate photons in response to the injection of electrons. External electrode contacts permit application of a voltage differential across the anode and cathode to stimulate electron emissions from the cathode and resultant photon emissions from the semiconductor light emitting nanostructures of the anode. Embodiments of the invention also include the usage of nanostructured semiconductor materials as phosphors for conventional planar LED and nanowire array light emitting diodes and CFL. For the use in conventional planar LEDs, the nanostructures may take the form of quantum dots, nanotubes, branched tree-like nanostructure, nanoflower, tetrapods, tripods, axial heterostructures nanowires hetero structures.12-08-2011
20100090127TIME RESOLVED FLUORESCENT IMAGING SYSTEM - This invention provides a system and method that allows for time-resolved fluorescent imaging of fluorescent samples. The user is able to receive temporally filtered pictures of the sample with a reduced amount of the scattered excitation light and the short lived background fluorescence. The system allows for adjustment of fluorescent gating time and delay time.04-15-2010
20110291027METHODS AND SYSTEMS FOR SIMULTANEOUS REAL-TIME MONITORING OF OPTICAL SIGNALS FROM MULTIPLE SOURCES - Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.12-01-2011
20110186752METHOD AND DEVICE FOR DETERMINING THE RATIO BETWEEN THE CONTENTS OF CHLOROPHYLL AND OF A CHROMOPHORE COMPOUND IN A VEGETABLE TISSUE WITHOUT INDEPENDENTLY MEASURING SAID CONTENTS - A method and device for determining the ratio of the contents of chlorophyll and of a chromophorous compound that is non-fluorescent in the band of chlorophyll fluorescence in a plant tissue, without determining the contents. The method includes: 08-04-2011
20090250631APPARATUS AND METHOD FOR FLUORESCENCE IMAGING AND TOMOGRAPHY USING SPATIALLY STRUCTURED ILLUMINATION - An imaging system is disclosed for imaging an object. More specifically, an improvement is disclosed in an imaging system enabling depth sectioned fluorescence imaging in a turbid medium, such as human or animal tissue, in such a manner as to substantially minimize the excitation radiation from reaching the detection beam path. The imaging system includes an arrangement of the excitation radiation source such that the optical axis of the source is inclined relative to the optical axis of the camera, the optical plane of the source and the optical plane of the object are subject to a Scheimpflug condition provided by projection optics, and the angle of inclination of the source is selected such that the excitation radiation incident upon the object is reflected in such a way that substantially minimizes excitation radiation from reaching the detection beam path.10-08-2009
20120286171FLUORESCENCE MEASURING APPARATUS AND FLUORESCENCE MEASURING METHOD - Disclosed herein is a fluorescence measuring apparatus capable of determining whether accuracy of measuring fluorescence lifetime is deteriorated or not due to adjustment of the apparatus. The fluorescence measuring apparatus for measuring fluorescence emitted when an objects to be measured are irradiated with laser light includes: a laser light source that irradiates each of the objects to be measured with intensity-modulated laser light; a light-receiving unit that receives fluorescence emitted when each of the objects to be measured is irradiated with the laser light; a signal processing unit that determines a fluorescence lifetime using a signal of the fluorescence received by the light-receiving unit; and a determining unit that determines whether or not a fluorescence lifetime dispersion of the objects caused by amplification of the signal of the fluorescence performed by the light-receiving unit or by the signal processing unit is larger than a predetermined value.11-15-2012
20120025101METHOD OF DECOMPOSING CONSTITUENTS OF A TEST SAMPLE AND ESTIMATING FLUORESCENCE LIFETIME - The present invention relates to a method of decomposition of a test sample into constituents thereof. The method proceeds by optically imaging the test sample to obtain a corresponding unknown time-domain resolved signal and decomposes the unknown time-domain resolved signal by comparing the unknown time-domain resolved signal with time-domain resolved reference signals. Furthermore, the method allows the determination of the presence or absence of constituents. Relative quantities may also be determined if sample material properties are known or taken into account. Lifetime decay of the constituents may also be estimated by handling effect of light diffusion in the test sample as time decay.02-02-2012
20090189089VALVE CONTROL SYSTEM FOR A ROTATING MULTIPLEX FLUORESCENCE DETECTION DEVICE - Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.07-30-2009
20080272313Luminescence Sensor Operating in Reflection Mode - The present invention relates to a luminescence sensor (11-06-2008
20100224797Method And Device For 3D Reconstruction Of The Distribution Of Fluorescent Elements - A device and method for processing fluorescence signals emitted after excitation by radiation coming from a radiation source, by at least one fluorophore with a lifetime τ in a surrounding medium, which signals are detected by detection means, and which method includes the calculation, on the basis of detected fluorescence signals, of values of a variable, independent of τ, of the position or the distribution of fluorophore in said medium.09-09-2010
20090146078SYSTEMS AND METHODS FOR EXTENDING THE USEFUL LIFE OF OPTICAL SENSORS - The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.06-11-2009
20100065756Nano-particle/quantum dot based optical diode - A particle based optical diode having at least two cavities or at least two regions of a single cavity, wherein the regions contain different types of particles.03-18-2010
20110147615Method and apparatus for microscopic imaging system with wide field of view and high collection efficiency - A microscopic imaging system using a laser excitation source, a scanner system, an optical relay system, a first focusing lens, a sample container and a detection system is used to examine tissue and other biological samples. The microscopic imaging system uses a relay optics and simplified compact object to produce a curved image plane in the sample and a method for transforming the curved image field into Cartesian coordinates is described. The system can incorporate a focus compensation system within the compact object to improve the imaging through the sample. The system can incorporate a sample chamber with integrated optics to improve the collection efficiency of the detection system in the microscopic imaging system. The system can incorporate a movable mirror with other fold mirrors to allow for multi-sided imaging of a sample.06-23-2011
20100084571RADIOISOTOPE POWERED LIGHT MODULATING COMMUNICATION DEVICES - The present disclosure relates to a light modulating communication device comprising a housing comprising at least one inner chamber, and an opening, at least one quantum dot positioned inside the at least one inner chamber, a high-energy emitting source positioned within the at least one inner chamber, a modulator positioned proximal to the opening of the housing, and optionally, at least one reflector positioned within the at least one inner chamber. The present disclosure also relates to a method comprising providing at least one quantum dot, contacting the at least one quantum dot with high-energy particles such that light is produced from the at least one quantum dot, and modulating the light produced from the at least one quantum dot.04-08-2010
20120091365ENHANCEMENT OF MOLECULAR EMISSION USING OPTICAL-ANTENNA STRUCTURES - The present disclosure relates to an apparatus, and methods of use, for enhancement of molecular emission by nano-antennas. Using the nano-antennas, the life-time is greatly shortened or the strength of broadly peaking spectral emission of fluorescent molecules is greatly enhanced by a generated electric field. The electric field generated is due to opposing charges located at two metallic end portions of the nano-antenna in response to receiving optical energy.04-19-2012
20100078576Systems and Methods for Optical Imaging Using Early Arriving Photons - Optical imaging systems and methods use early photons in order to generate processed fluorescent light images of fluorescent material on or within a tissue. The early photons are generated in accordance with a pulsed light source and an early-photon light receiver. The processed fluorescent light images tend to have improved resolution and imaging accuracy compared with fluorescent light images generated with photons beyond the early photons portions.04-01-2010
20090206278PHOTO-OPTICAL-ELECTRONIC GAS, PRESSURE AND TEMPERATURE SENSOR - A sensor according to the invention includes a surface having a sensing material that is responsive to a change in an environmental condition when illuminated. An illumination source is positioned to illuminate the surface. A receiver is positioned to receive light emanating from the surface; and a detector detects a change in light received at the receiver.08-20-2009
20090250632Method and Arrangement for Collimated Microscopic Imaging - A method and arrangement for collimated microscopic imaging, including a first illumination of a sample in at least one region for exciting fluorescence, and a spatially resolving detection of the sample light by detector elements, the detection being associated with the region, wherein by means of a second illumination a sub-division of the region into separate fluorescent partial regions occurs, which are associated with the detector elements. The separation of the partial regions is carried out by the spatial separation of the fluorescent regions by means of intermediate regions having reduced fluorescence or no fluorescence, and/or by means of different spectral properties of the fluorescence from the partial regions.10-08-2009
20090250630PHOTODIODE FOR DETECTION WITHIN MOLECULAR DIAGNOSTICS - A photodiode (10-08-2009
20090090873Method and system for detection of contrast injection in fluoroscopic image sequences - A method and system for detecting a spatial and temporal location of a contrast injection in a fluoroscopic image sequence is disclosed. Training volumes generated by stacking a sequence of 2D fluoroscopic images in time order are annotated with ground truth contrast injection points. A heart rate is globally estimated for each training volume, and local frequency and phase is estimated in a neighborhood of the ground truth contrast injection point for each training volume. Frequency and phase invariant features are extracted from each training volume based on the heart rate, local frequency and phase, and a detector is trained based on the training volumes and the features extracted for each training volume. The detector can be used to detect the spatial and temporal location of a contrast injection in a fluoroscopic image sequence.04-09-2009
20090309044Luminescent Composition - The invention relates to a luminescent composition which is based on yttrium oxide sulfide and other oxide sulfides and to which at least one doping agent is added. The inventive composition has a characteristic emission spectrum and can optionally be used along with a reading system that is adjusted to the emission spectrum in order to mark substances or substance mixtures.12-17-2009
20100123088ENHANCED INSTRUMENTATION AND METHOD FOR OPTICAL MEASUREMENT OF SAMPLES - The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrumentation wherein a sample (05-20-2010
20110168918DETECTION SYSTEM AND METHOD - A detection system combines an excitation radiation source (07-14-2011
20110168917FLUORESCENCE DETECTION DEVICE USING INTENSITY-MODULATED LASER LIGHT AND FLUORESCENCE DETECTION METHOD - A fluorescence detection device for a flow site meter emits laser light intensity-modulated in accordance with a modulation signal and acquires a fluorescent signal of fluorescence emitted from a measurement object that passes through a measurement point of the laser light. The fluorescence detection device generates, separately from the modulation signal, a reference signal having a frequency different from a frequency of the modulation signal and a phase in synchronization with a phase of the modulation signal. The fluorescence detection device determines a fluorescent relaxation time of the measurement object from the fluorescent signal by using the reference signal.07-14-2011
20110168916FLUORESCENCE DETECTION DEVICE USING INTENSITY-MODULATED LASER LIGHT AND FLUORESCENCE DETECTION METHOD - Fluorescence detection device employed in a flow site meter emits laser light intensity-modulated by a modulation signal and acquires the fluorescence signal of fluorescence emitted from a measurement object passing through a measurement point of the laser light. The device generates the reference signal, separately from the modulation signal, the reference signal having a frequency different from the frequency of the modulation signal and having a phase synchronized with a phase of the modulation. The device determines fluorescence relaxation time of the measurement object from the fluorescence signal using the reference signal.07-14-2011
20110168914MICROSCOPY SYSTEM, MICROSCOPY METHOD AND METHOD OF TREATING AN ANEURYSM - A microscopy system and method are provided allowing observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.07-14-2011
20110168915Fluorescence Imaging Apparatus and Method for Detecting Fluorescent Image - In order to reduce light leak influencing the detection capability of a fluorescence imaging apparatus, an interference filter and an absorption filter on an emission-side filter section are arranged serially in the traveling direction of the fluorescence. The interference filter and the absorption filter that are in use for such an arrangement block the waveband light equivalent to the excitation light irradiated onto a sample while fully transmitting the waveband light equivalent to the fluorescence.07-14-2011
20090289200Fluorescent image obtainment method and apparatus, fluorescence endoscope, and excitation-light unit - A fluorescent image obtainment apparatus includes a light illumination means that illuminates a region to be observed with illumination-light and excitation-light at the same time, and an imaging means that captures an image composed of light reflected from the region illuminated with the illumination-light and an image composed of fluorescence output from the region illuminated with the excitation-light. Further, the apparatus includes an image processing means that produces an ordinary image based on the image of the reflection light and a fluorescent image based on the image of fluorescence, and a light amount control means that controls the light amount of the illumination-light so that a representative luminance value of the ordinary image becomes a predetermined luminance value and the light amount of the excitation-light so that the ratio of the light amount of the excitation-light to that of the illumination-light becomes a predetermined ratio.11-26-2009
20090272914COMPENSATOR FOR MULTIPLE SURFACE IMAGING - A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may, for instance, be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The captured and detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection (TIR) methods may benefit from the techniques of the present invention. In addition, the biological samples imaged may be present on the surfaces of the support structure in a random special pattern and need not be at known locations in order for the imaging to be performed.11-05-2009
20090283699FREQUENCY DOMAIN LUMINESCENCE INSTRUMENTATION - Instrumentation for measuring luminescence phase lag to quantitate an analyte concentration is corrected to eliminate or reduce extraneous phase lag noise. A calibration factor is determined in steps that are interspersed between quantitative measurements. An optical pathway is provided to accomplish the calibration by the provision of a second optical source that emits in the luminescence emission band of a luminescent material. The calibration factor may be subtracted from measurement of the quantification phase lag to correct for extraneous phase lag.11-19-2009
20090283700FLUORESCENCE DETECTING METHOD - A fluorescence detecting method utilizes surface plasmon enhancement. An electric field enhancing field is caused to be generated at a detecting portion that includes a metal film provided on a surface of a dielectric prism. Fluorescence emitted by fluorescent labels, which are attached to a detection target substance, due to the excitation effect of the electric field enhancing field is detected by a photodetector. During the detection, a plurality of fine metal particles are dispersed on the detecting portion.11-19-2009
20090294693APPARATUS AND METHOD FOR OPTICAL EXAMINATION OF DOCUMENTS - An apparatus for optical examination of documents. The apparatus includes a light source, a viewing unit having a window through which light emitted from the light source exits for examination of documents by an observer. A method for optical examination of a document. The method steps include: providing a light source; emitting light from the light source into a viewing unit; emitting light from the viewing unit through a window; applying fluid to a document to be viewed; and, bringing the document into contact with the window such that an observer can examine the document.12-03-2009
20110204258SPECTRAL IMAGING OF PHOTOLUMINESCENT MATERIALS - A near infrared imaging and detection system is configured to analyze shifts in photoluminescence of individual nanostructures such as single-walled carbon nanotubes or quantum dots upon binding an analyte. The system can be used to detect, localize, and quantify analytes down to the single-molecule level in a sample and within living cells and can be operated in a multiplex format. The system also can be configured to perform high-throughput chemical analysis of a large number of samples simultaneously. The invention has application in the highly sensitive diagnosis of disease, as well as the detection and quantitative analysis of drugs, molecular pathogens within a living organism, and environmental toxins.08-25-2011
20090266999Apparatus and method for fluorescent imaging - An apparatus and method for fluorescent imaging. The apparatus includes a light-generating means for generating at least one modulated fluorescence excitation beam, a light retransmitting means for retransmitting the fluorescence excitation beam onto an area that is to be examined, a light-imaging means for imaging a fluorescent beam from the area to be examined onto a first image sensor, a control and evaluation means for controlling the light-generating means to power the first image sensor and for evaluating the data supplied by the first image sensor to generate a fluorescent image, where the fluorescent excitation beam may be continuously modulated, the first image sensor is a solid state detector that may be powered phase-sensitively, and the data supplied by the first image sensor contain pixel by pixel phase information on the fluorescent beam.10-29-2009
20090261269OPTICAL SIGNAL DETECTION METHOD, APPARATUS, SAMPLE CELL AND KIT - A sensor chip includes a dielectric plate and a sensor portion having a metal layer deposited on a predetermined area on the dielectric plate. A photo-reactable labeling-substance of an amount corresponding to the amount of a substance to be detected in a sample binds to the sensor portion by contacting the sample with the sensor portion. The amount of the substance to be detected is obtained by irradiating the predetermined area with excitation light and by detecting light output from the photo-reactable labeling-substance in an enhanced electric field that has been generated on the metal layer by irradiation with the excitation light. The photo-reactable labeling-substance includes a photo-reactable substance enclosed by a light transmissive material that transmits light output from the photo-reactable substance to prevent metal quenching that occurs when the photo-reactable substance is located close to the metal layer.10-22-2009
20100276608High-Resolution Microscope Using Optical Amplification - Systems and methods that enhance the resolution of a microscope in all three spatial dimensions. A microscope system is provided that typically includes a first objective lens (11-04-2010
20120292532DOSIMETRY SYSTEM BASED ON OPTICALLY STIMULATED LUMINESENCE - Methods for detecting exposure to ionizing radiation are provided. In particular, methods for detecting and measuring the exposure of keratin-rich materials to ionizing radiation using optically stimulated luminescence are provided.11-22-2012
20110006220FLUORESCENT-IMAGE ACQUISITION APPARATUS, FLUORESCENT-IMAGE ACQUISITION METHOD AND FLUORESCENT-IMAGE ACQUISITION PROGRAM - Disclosed herein is a fluorescent-image acquisition apparatus including an excitement-light source; an objective lens; an image pickup device; focal-point movement control means; and image-pickup control means.01-13-2011
20110204259METHOD AND SYSTEM FOR DETECTING FLUOROCHROMES IN A FLOW CYTOMETER - A method for detecting fluorochromes in a flow cytometer, including: receiving a sample including particles each tagged with at least one of a first fluorochrome and a second fluorochrome, in which the first and second fluorochromes having distinct spillover coefficients; detecting the particles, including detecting the first and second fluorochromes with a first detector and a second detector; forming a data set for detected particles based on the detection of the first and second fluorochromes; characterizing a detected spillover coefficient for each detected fluorochrome from the data set; and sorting the detected particles into predicted fluorochrome populations based on the detected spillover coefficients. A system for detecting fluorochromes in a flow cytometer, including a flow cell, a fixed gain detection system, and a processor that generates a detected spillover coefficient for each detected particle and sorts the detected particle into predicted fluorochrome populations based on the detected spillover coefficient.08-25-2011
20110140003Test apparatus for an optical investigation system - A test apparatus for an optical investigation system, with an imaging device and a light source for optical investigation of an object in remitted light and/or fluorescent light includes a housing with a hollow space and an aperture for inserting a distal end of the imaging device into the hollow space, a reference surface with predetermined optical properties in the hollow space, at least either for remission of illuminating light directed onto the reference surface or for emission of fluorescent light, and a positioning device to hold the imaging device of the distal end of the imaging device at a predetermined position in relation to the reference surface.06-16-2011
20110266461METHOD AND A DEVICE FOR MEASURING FLUORESCENCE LIFETIME - The invention refers to a method for measuring fluorescence lifetime. An excitation light radiation (11-03-2011
20110266460Method and a Device for Detecting the Fluorescence of a Biochip - An imaging method and a device for detecting the fluorescence of a biochip by illuminating chromophores associated with probes (11-03-2011
20110266459MULTI-FUNCTIONING MATERIAL COMPOSITIONS, STRUCTURES INCORPORATING THE SAME AND METHODS FOR DETECTING AGEING IN LUMINESCENT MATERIAL COMPOSITIONS - A multi-functional material composition comprising a zirconia host and containing a luminescent lanthanide oxide additive, in particular dysprosia (D11-03-2011
20100102250PHOSPHOR BASED AUTHENTICATION SYSTEM - A phosphor (photo-luminescent) material based authentication system in which a blend (mixture) of at least two, preferably three or more, phosphor materials are used as a photo-luminescent security marking which is applied to or incorporated within an article/document to be authenticated. Preferably, the phosphor materials are each excitable by “eye safe” excitation radiation comprising visible light of wavelength 380 nm to 780 nm. Moreover, when excited the security marking preferably also emits visible light thereby minimizing any risk of damage to an operator's eye in the event of accidental exposure to the excitation radiation and/or light generated by the photo-luminescent marking. The authenticity of the article/document can be authenticated by verification of the composition of the phosphor by exciting the marking and comparing one or more selected parameters of light emitted by the security marking with corresponding parameters of the characteristic emission spectrum of the authentic phosphor blend.04-29-2010
20120261591DEVICE AND METHOD FOR DETERMINING THE CONCENTRATION OF FLUOROPHORES IN A SAMPLE10-18-2012
20080290294System for Synchronous Detection of Fluorescence in a Drop - A method for producing a modulated optical signal from a droplet of a liquid medium. The method positions a droplet of liquid on a hydrophobic surface, in the path of an optical beam, and modulates the shape of the droplet on this surface, by electrowetting, to modulate the signal obtained after passing the optical beam through the droplet.11-27-2008
20120292531Optical Sources - An optical source (11-22-2012
20120043478Fluorescent Estimating Apparatus, Fluorescent Estimating Method, and Fluorescent Measuring Apparatus - This invention provides a technique for efficiently estimating spectral radiance factors of fluorescence of a sample. To this end, for a sample which contains a fluorescent substance, first spectral reflectance data and second spectral reflectance data are obtained by making two different variable-angle measurements using a general colorimeter under a white light source. Ratios n of the first spectral reflectance data to the second spectral reflectance data in a long-wavelength spectrum range outside a fluorescent spectrum range of the sample are calculated. Then, difference data between spectral reflectance data as results of multiplying the second spectral reflectance data by the ratios n, and the first spectral reflectance data are calculated. The difference data are divided by values obtained by subtracting 1 from the ratios n, thereby calculating spectral reflectances of fluorescence of the sample, that is, spectral radiance factors.02-23-2012
20130119272IMAGE OBTAINING APPARATUS, IMAGE OBTAINING METHOD, AND IMAGE OBTAINING PROGRAM - An image obtaining apparatus includes: a light source configured to irradiate a biological sample having a fluorescent label with an excitation light, the excitation light exciting the fluorescent label; an optical system including an objective lens, the objective lens being configured to magnify an imaging target of the biological sample; an image sensor configured to form an image of the imaging target magnified by the objective lens; a movement controller configured to move a focus position of the optical system in an extended range, the extended range being obtained by adding predetermined margins to both ends of the imaging target in a thickness range; and a light-exposure controller configured to expose the image sensor to light while moving the focus position of the optical system in the extended range.05-16-2013
20130119273Method and Apparatus for Illumination and Detection in RESOLFT Microscopy - A method for illumination and detection in RESOLFT microscopy using a pulsed or continuous light source for excitation light and switching light is characterized in that the excitation light (05-16-2013
20130119275High Throughput Hot Testing Method And System For High-Brightness Light-Emitting Diodes - A method of performing a hot test of a wafer-level, packaged high-brightness phosphor converted light-emitting diode (pc-HBLED) includes selectively heating portions of the phosphor layer using a laser to provide a predetermined temperature gradient in the phosphor layer. The selective heating can directly heat the silicone in a silicone-based phosphor layer, or directly heat the active ion(s) of the phosphor in a Lumiramic™-based phosphor or even the active ion(s) of a silicone-based phosphor layer. A current is applied to the InGaN film to establish a predetermined temperature at the InGaN film junction, the film junction being adjacent to the phosphor layer. Photometric measurements are performed on the HBLED after the selective heating and during the applied electroluminescent current. This method quickly establishes the temperatures and temperature gradients in the HBLED consistent with those of an operating, product-level HBLED, thereby ensuring accurate binning of the HBLED.05-16-2013
20130119276Method for Measuring the Lifetime of an Excited State in a Sample - The present invention relates to a method for measuring the lifetime of an excited state in a sample, in particular a fluorescence lifetime, and to an apparatus for carrying out such a method. First, an excitation pulse is generated and a sample region is illuminated with the excitation pulse. Then, a first digital data sequence is generated which is representative of the power-time profile of the excitation pulse, and a first switching instant is determined from the first digital data sequence. Moreover, the detection light emanating from the sample region is detected by a detector, and a second digital data sequence is generated which is representative of the power-time profile of the detection light, and a second switching instant is determined from the second digital data sequence. Finally, the time difference between the first and second switching instants is calculated.05-16-2013
20130119277DYNAMIC SIGNAL EXTENSION IN OPTICAL DETECTION SYSTEMS - Systems and methods for measuring a target in a sample, the target being capable of generating an emitted light in response to an excitation light. In an example system, an excitation light source generates the excitation light along an excitation optical path. An attenuation filter arrangement selectively adds an attenuation filter to the excitation optical path. The attenuation filter attenuates the excitation light by a corresponding attenuation factor. The excitation light exits the attenuation filter arrangement along the excitation optical path to illuminate the sample. A light energy detector receives the emitted light generated in response to the excitation light, and outputs a measured signal level corresponding to an emitted light level. If the light energy detector indicates an overflow, signal measurement is repeated with attenuation filters of increasing attenuation factors until the measured signal level does not overflow.05-16-2013
20100264331METHOD FOR ASSAYING NUCLEIC ACIDS BY FLUORESCENCE - The invention relates to a method for determining the amount of nucleic acid present in a sample, wherein:—a fluorophore is added to the sample,—fluorescence intensities emitted by the fluorophore at least two emission wavelengths in response to light stimulations at least two excitation wavelengths respectively are measured, and—the amount of nucleic acid present in the sample is deduced from the measured fluorescence intensities.10-21-2010
20110006219DATA ACQUISITION METHOD USING A LASER SCANNER - The invention relates to a data acquisition method using a laser scanner for the pixel-precise imaging of fluorescent samples which are on object carriers and have been treated with fluorescent dyes. Such a laser scanner comprises a sample table; at least one laser and a first optical system for providing at least one laser beam for exciting the fluorescent samples; a scanner head (01-13-2011
20100140502OXYGEN SENSITIVE MATERIAL, SENSORS, SENSOR SYSTEMS WITH IMPROVED PHOTOSTABILITY - An oxygen sensitive polymeric material with enhanced photostability, comprising an oxygen sensitive indicator and photostabilizer incorporated into an oxygen permeable polymeric material is provided. The oxygen sensitive indicator can be, but is not limited to, [Ru(L1)(L2)(L3)]06-10-2010
20100140506METHOD OF DETERMINING A MEASUREMENT VALUE ON THE BASIS OF SINGLE MOLECULE EVENTS - A method of determining a measurement value on the basis of a plurality of single molecule events of marker molecules in a sample comprises the steps of selecting the marker molecules from a group of marker molecules which are transferable between a measurable state in which a measurement signal necessary for determining the at least one measurement value is obtainable from the marker molecules and a non-measurable state, of providing the marker molecules in the sample at such an absolute concentration that the at least one measurement value is not determinable, if all marker molecules are in their measurable state, and adjusting a measurement concentration of the marker molecules in the measurable state by means of applying the physical signal to the sample at such an intensity that the at least one measurement value is determinable within a defined measurement area of the sample.06-10-2010
20110204257HAEMOZOIN DETECTION - A system for detecting haemozoin in a sample, said system including a light source for exciting the sample with an optical signal to generate a non-linear optical response, and a detector for detecting the generated non-linear optical response from the excited sample. A method for detecting haemozoin in a sample, the method including exciting the sample with an optical signal to generate a non-linear optical response from the sample, and detecting the emitted non-linear optical signal from the excited sample.08-25-2011
20100140501FLUORESCENCE NOTCH CODING AND AUTHENTICATION - Systems and methods for document and product authentication using a variety of absorption and emission signatures are disclosed. Emission signatures in the form of florescent or phosphorescent coatings, inks and substrates are used for authentication and protection of items such as documents, currency, and secondary packaging for tobacco, luxury goods and pharmaceuticals. Spectrally overlapping absorption and emission materials are combined to provide a unique spectral fingerprint detectable by a scanner.06-10-2010
20100140505CAPILLARY ELECTROPHORESIS FLUORESCENT DETECTION SYSTEM - The invention includes a high sensitivity and high throughput capillary electrophoresis multiwavelength florescence detection system. The fluorescent detection system is configured to illuminate a relatively large volume of a single capillary or a plurality of capillaries, with a pixelated detection system capable of imaging an area of each capillary that differentiates the capillary walls, the space between the capillaries, and the internal liquid volume within the capillary. Only the desired pixels or image area are used for processing and generating an output signal.06-10-2010
20100140504FLUORESCENCE MEASUREMENT - Methods and apparatus for measuring fluorescence, are described. The method includes measuring at least one profile of at least a portion of a surface of a sample, the surface extending substantially transverse an axis, and illuminating the portion of the sample surface with radiation for stimulating fluorescence. The intensity of the radiation varies with position along the axis. Values indicative of the spatial intensity distribution of fluorescence emitted from said portion of the sample surface are measured. The measured values of fluorescence are modified to take account of the spatial variation in intensity of radiation incident upon the surface by utilising the measured profile.06-10-2010
20090184257APPARATUS AND METHOD FOR MEASURING AND/OR CONTROLLING ULTRAVIOLET-ACTIVATED MATERIALS IN A PAPER-MAKING PROCESS - A method includes illuminating a mixture of materials in a wet-end of a paper process, where the mixture includes an ultraviolet-activated material. The method also includes measuring light from the mixture and determining a property of the ultraviolet-activated material based on the measured light. The method may further include adjusting an operation in the wet-end of the paper process based on the determined property of the ultraviolet-activated material. The determined property could include a quantity of fluorescent material in recycled material used to form stock for a paper machine and/or a quantity of fluorescent material in stock provided to a headbox in the paper process. Adjusting the operation in the wet-end could include adjusting an amount of one or more materials used to form stock provided to the headbox, such as a fluorescent whitening agent, fixative, fluorescent fiber, fluorescent pigment, fluorescent particle, fluorescent highlight, fluorescent planchette, or fluorescent quencher.07-23-2009
20090250629Methods for Detecting Fluorescent Signals in a Biological Sample - Operational means for automatic microscopic detection and analysis of fluorescent signals from a treated biological sample.10-08-2009
20110031412METHOD OF LUMINESCENT SOLID STATE DOSIMETRY OF MIXED RADIATIONS - A method of determining the doses of neutrons, gamma and X-ray photons, beta, alpha and other ionizing radiations using a method of image processing in spatial and frequency domain that produces parameters that are related to the radiation dose absorbed in a luminescent material. Portions of the luminescent material may be covered by different converters to allow for doses of different radiations to be discriminated.02-10-2011
20090321661DETECTING METHOD, DETECTION SAMPLE CELL, AND DETECTING KIT - A fluorescent substance having fluorescent pigment molecules, which are enveloped in a light transmitting material that transmits fluorescence generated by the fluorescent pigment molecules, is employed as fluorescent labels in a detecting method the detects the amount of a detection target substance based on the amount of light which is generated due to excitation of the fluorescent labels. The fluorescent substance is excited by evanescent waves which are generated due to leakage from an optical waveguide mode.12-31-2009
20090321660DISPERSIONS OF LUMINESCENT RARE-EARTH OXIDE PARTICLES, VARNISH COMPRISING THESE PARTICLES, THEIR METHODS OF PREPARATION AND METHOD FOR MARKING SUBSTRATES - Dispersion of particles of at least one oxide of at least one luminescent rare earth, disaggregated and stabilized in a hydrophobic liquid medium containing at least one surfactant, in which the said surfactant is a non-ionic surfactant having an HLB (hydrophilic-to-lipophilic balance) lower than 12.12-31-2009
20090026386SYSTEM AND METHOD EMPLOYING PHOTOKINETIC TECHNIQUES IN CELL BIOLOGY IMAGING APPLICATIONS - A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.01-29-2009
20110226965INCREASED RESOLUTION MICROSCOPY - Method for spatially high-resolution luminescence microscopy in which label molecules in a sample are activated to emit luminescence radiation comprising activating only a subset of the label molecules in the sample, wherein activated label molecules have a distance to the closest activated molecules that is greater or equal to a length which results from a predetermined optical resolution, detecting the luminescence radiation, generating a frame from the luminescence radiation, identifying the geometric locations of the label molecules with a spatial resolution increased above the predetermined optical resolution, repeating the steps and forming a combined image, and controlling the acquisition of the several frames by evaluating at least one of the frames or a group of the frames and modifying at least one variable for subsequent repetitions of the steps of generating frames for combining into an image.09-22-2011
20090101839LASER SCANNER APPARATUS FOR FLUORESCENCE MEASUREMENTS - The invention relates to a laser scanner apparatus (04-23-2009
20090101837MULTILAYER IDENTIFICATION MARKER COMPOSITIONS - Multi-layer identification markers, which comprise at least two layers that contain combinations of absorbers and fluorescence emitters, are described. The multi-layer identification markers may have application as security markers and security coatings.04-23-2009
20090224174Calibration device and laser scanning microscope with such a calibration device - A calibration device for managing a variety of performance tests and/or calibration tasks in a laser scanning microscope. The calibration device, which has focusing optics and a test structure arranged in the focal plane of the focusing optics, with structural elements detectable in reflected and/or transmitted light aligned to each other in a common mounting, can be switched into the microscope beam path in a laser scanning microscope, so that the pupil of the focusing optics coincides with the objective pupil of the laser scanning microscope or lies in a plane conjugated to it.09-10-2009
20090230324Methods and Devices for Characterizing Particles in Clear and Turbid Media - The invention provides methods and devices for detecting, identifying, classifying and characterizing particles in a fluid sample. Optical analyzers are provided having a rotating and/or translating sample container for measuring the concentrations of fluorescent particles present in very low concentrations and for characterizing fluorescent particles on the basis of size, shape, diffusion constant and/or composition. Scanning optical analyzers are provided using pattern recognitions data analysis techniques and multichannel detection.09-17-2009
20090230323Fluorometer with low heat-generating light source - This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a plurality of sample containers, such as capped PCR tubes in a standard titer tray. The fluorometer of the present invention further comprises an optical path between each LED and its correspondingly positioned container, and another optical path between each fluorescing sample within the positioned container and an optical signal sensing means. The instrument can be computer controlled.09-17-2009
20090212235SCANNING FLUORESCENT READER WITH DIFFUSER SYSTEM - A fluorescence detection apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. The excitation light generator includes a diffuser to provide a more uniform light distribution. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module can interrogate different wells while in motion over the wells.08-27-2009
20090242800Electron-beam dimension measuring apparatus and electron-beam dimension measuring method - An electron-beam dimension measuring apparatus includes: electron-beam irradiating means for irradiating a surface of a sample with an electron beam; a stage on which the sample is placed; a photoelectron generating electrode disposed so as to face the sample; ultraviolet light irradiating means for emitting ultraviolet light; and control means for causing the ultraviolet light irradiating means to irradiate the sample and the photoelectron generating electrode with the ultraviolet light for a predetermined length of time, to cause the sample and the photoelectron generating electrode to emit photoelectrons, for applying a voltage to the photoelectron generating electrode, the voltage applied to supply energy corresponding to a difference between energy of photoelectrons emitted by the sample and energy of photoelectrons emitted by the photoelectron generating electrode, and thereby for controlling an electric potential of the surface of the sample to set the electric potential at 0 V. The control means measures the dimension of the sample after keeping the electric potential constant on the surface of the sample.10-01-2009
20090242801METHOD OF FLUORESCENCE-MICROSCOPICALLY IMAGING A STRUCTURE IN A SAMPLE WITH HIGH THREE-DIMENSIONAL SPATIAL RESOLUTION - For imaging a structure in a sample with three-dimensional spatial resolution, a fluorophore is selected which is transferable by means of an optical transfer signal out of a first into a second photochromic state having specific fluorescence properties, and which displays a return rate back into the first photochromic state. The structure is labeled with the fluorophore. Via a common objective, the sample with the labeled structure is subjected both to the optical transfer signal in a spatially limited transfer-volume, and to an optical excitation signal exciting a portion of the fluorophore being in its second photochromic state for fluorescence in a spatially limited excitation-volume, the transfer-volume and the excitation-volume having a common centre of maximum intensity of the transfer signal and of the excitation signal, and a decrease of intensity of the transfer signal with the distance to the common centre of maximum intensity being substantially stronger than any decrease of the effective return rate of the fluorophore. Fluorescence light emitted by the excited fluorophore is detected. The common centre of maximum intensity is shifted with regard to the sample; and the steps of subjecting and detecting are repeated.10-01-2009
20100264332APPARATUS AND METHOD FOR DETECTION AND MEASUREMENT OF TARGET COMPOUNDS SUCH AS A FOOD TOXIN - A method for the detection or determination of a target comprising a plurality of target compounds, or derivatised target compounds, said method comprising: immobilising said target on a carrier, directing radiation at said target, said radiation being selected to cause said target to emit a relevant radiation, detecting said relevant radiation emitted by said target, and analysing said detected radiation to identify and/or quantify the plurality of target compounds in said target.10-21-2010
20090242802FLOURESCENCE DETECTING METHOD AND FLUORESCENCE DETECTING APPARATUS - An excitation light beam of a wavelength that excites fluorescent labels and a reference light beam having a wavelength longer than the excitation light beam are irradiated through a dielectric block toward an interface between the dielectric block and a metal film, to cause a first electric field enhancing field and a second electric field enhancing field on the upper surface of the metal film, in fluorescence detection that utilizes surface plasmon. The intensity of scattered light of the second electric field enhancing field, which is substantially proportionate to the intensity of the second electric field enhancing field, is employed to normalize and correct the intensity of fluorescence emitted by fluorescent labels with respect to the intensity of the first electric field enhancing field, based on the relationship between the intensities of the first and second electric field enhancing fields.10-01-2009
20090242799METHOD FOR THE DETECTION OF BIOLOGIC PARTICLE CONTAMINATION - Methods for detecting particles in a fluid, including determining particle size and intrinsic fluorescence of a particle, and time correlating the particle detection data with image data in the vicinity of the detector or detector inlet to identify contamination sources in clean environments are described.10-01-2009
20110101243MICROARRAY CHARACTERIZATION SYSTEM AND METHOD - A system and method is described for detecting a plurality of analytes in a sample. The characterization system (05-05-2011
20110101242METHODS, APPARATUS AND SYSTEMS EMPLOYING MULTIPLE ENERGY SOURCES FOR ANALYZING COMPOSITIONS - An apparatus for analyzing a composition includes an excitation source adapted to transmit incident energy, the excitation source comprising an array of energy emitting sources, and a plurality of photometric detectors adapted to receive radiation emitted from the composition when the incident radiation is transmitted thereto.05-05-2011
20100155622METHOD AND DEVICE FOR LOCALISING FLUOROPHORES OR ABSORBERS IN A SURROUNDING MEDIUM - The invention relates to a method of localising a fluorophore (06-24-2010
20100187441TRANSILLUMINATOR ADAPTOR FOR CONVERSION OF ULTRAVIOLET RADIATION TO VISIBLE LIGHT - An adaptor is designed as an accessory to an ultraviolet transilluminator for the excitation of fluorescent molecules or labels in a planar array of biochemical samples such as a two-dimensional electrophoresis gel to enable the emissions resulting from the excitation to be detected and quantified. The adaptor is constructed to overlay the transilluminator and contains both a fluorescent dye that upon excitation by ultraviolet light emits light in the visible spectrum, and a conditioning substance that selects a portion of the wavelength band of the visible light produced by the fluorescent dye. The adaptor converts the ultraviolet light from the transilluminator to visible light while limiting the emissions reaching the detector to those that emanate from the sample. By the use of this adaptor, the transilluminator is adapted for use with samples labeled with dyes that are excitable by visible light and avoids exposure of the samples and the user to ultraviolet light.07-29-2010
20100187440LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.07-29-2010
20100258740FLUORESCENCE DETECTION METHOD - A fluorescence detection method allows fluorescence intensity detection from a fluorescently-labeled biological sample with high accuracy in shorter time, even when a fluorescence intensity from a microchip itself acting as background. A fluorescence intensity from an equivalent microchip, which is equivalent to a microchip with the fluorescently-labeled biological sample, is detected for a period from the start of application of excitation light until the intensity sufficiently attenuates, and a temporal change of the intensity is stored. The light is applied to the microchip and the sample is fed before the fluorescence intensity from the microchip sufficiently attenuates to detect the fluorescence intensity for a period from the start of application of the light to a point after the sample is fed. Values of the temporal change are subtracted from the intensity detected from the microchip with the sample to detect an intensity of fluorescence emitted from the sample.10-14-2010
20090314957Branched Compounds And Their Use in Sensors - The invention provides sensors comprising one or more compounds of formulae (I) and (II):12-24-2009
20100193705APPARATUS AND METHOD FOR INTERLEAVING DETECTION OF FLUORESCENCE AND LUMINESCENCE - An apparatus is provided that is capable of interleaving detection of fluorescence and luminescence signals emitted from a plurality of samples. The apparatus is suitable for analysis of samples containing single cells or tissues up to and including living organisms. It contains an optical assembly or “sandwich” for producing a spectrally pure and spatially disperse light source for illuminating the sample. The invention also provides a plurality of optical sandwiches that can be variously geometrically arranged and their intensities programmed to create spatially uniform illumination over a large sample. The invention further provides an apparatus having at least one of the optical sandwich and a detector system capable of interleaving detection of fluorescent and luminescent signals when a suitable sample is illuminated by the light source of the optical sandwich. Methods for preparing samples and using the sandwiches, arrays and apparatus, are further provided by this invention. A method for interleaving detection of fluorescent and luminescent signals emitted from a plurality of samples is disclosed.08-05-2010
20090078886METHOD AND APPARATUS FOR CHECKING DOCUMENTS OF VALUE - The invention relates to a method and an apparatus for recognizing forged documents of value, wherein the documents of value are illuminated with clocked excitation light of a light source. Within the bright phase of the excitation light a first luminescence intensity is detected, within the dark phase a second luminescence intensity. Because of the afterglow of the light pulses there is a residual fluorescence, which distorts the luminescence intensity in the dark phase. By linking the second luminescence intensity with the first luminescence intensity, e.g. by subtracting a scaled first luminescence intensity, a corrected second luminescence intensity is determined, which substantially corresponds to the phosphorescence signal of the document of value.03-26-2009
20100258742DYE COMPOSITION FOR LIQUID TRANSFER CONTROL - The present invention provides kits and methods for composition ratio control based on dyes that are designed to enable energy transfer between each other. In more detail, with the method of the present invention it is possible to verify the mixing ratio of a first component comprising a first dye with a second component comprising a second dye.10-14-2010
20100258741METHOD AND DEVICE FOR IMAGING AN INTERIOR OF AN OPTICALLY TURBID MEDIUM - The invention relates to a method and a device (10-14-2010
20100213389METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR LOCALIZING PHOTONS AND A LIGHT SOURCE EMITTING THE PHOTONS - Localization methods and methods for localizing a light source using multivariate statistical analysis. In particular, a multi-variate distribution, such as a multi-variate normal distribution, may be used to localize photons originating from a light source and, in particular, may be used to analyze photon position maps acquired by Photon Event Distribution Sampling (PEDS). The multi-variate distribution assigned to each of the photons in the photon position map may be summed to predict a most probable location for the light source.08-26-2010
20100176307STED-Fluorescent Light Microscopy with Two-Photon Excitation - A method of high spatial resolution imaging a structure in a sample comprises: marking the structure with molecules of a fluorescent dye; selecting a first wavelength for excitation light which excites the molecules of the fluorescent dye via a multi photon process for spontaneous emission of fluorescent light; focussing pulses of the excitation light into the sample to excite those molecules of the fluorescent dye present in a focal area of the focussed excitation light; selecting a second wavelength shorter than the first wavelength for de-excitation light which de-excites excited molecules of the fluorescent dye prior to their spontaneous emission; during a plurality of the pulses of the excitation light, continuously directing the de-excitation light onto the sample to de-excite excited molecules of the fluorescent dye, which are located outside an measurement area which is a fraction of the focal area; and recording the fluorescent light spontaneously emitted by the molecules of the fluorescent dye in the sample.07-15-2010
20100230610INTEGRATED DEVICE HAVING AN ARRAY OF PHOTODETECTORS AND AN ARRAY OF SAMPLE SITES - An integrated device for detecting emissions from a sample (09-16-2010
20100213388METHOD AND DEVICE FOR DETECTING DEGRADATION IN THE QUALITY OF A BRAKE - A method and a device for detecting degradation in the quality of a brake fluid are disclosed. The brake fluid comprises a luminescent dye, wherein there is a change in luminescence emitted by the dye in response to a change in water content of the brake fluid.08-26-2010
20100237255OPTICAL FIBER SENSOR - A sensor based on optical fiber technology is described. The sensor includes an elongate core for propagating light having an excitation wavelength; an interaction region that includes a fluorescent material for excitation by the propagated light to produce fluorescent light; and an interface region defining a boundary between the elongate core and the interaction region. The elongate core of the sensor is adapted to increase an intensity of the propagated light at the interface region to increase the amount of captured fluorescent light in the elongate core.09-23-2010
20100219353APPARATUS AND METHOD OF ACQUIRING IMAGES OF A SAMPLE OF BIOLOGICAL ORIGIN - A novel apparatus and a novel method of imaging a luminescence phenomenon of a sample of biological origin using an optical image formation device are provided. In the inventive method and apparatus, an illumination image acquired by illuminating the sample and a luminescence image acquired with the light emitted by a luminescence phenomenon of a cell in the sample without illuminating it are superposed to generate a superposition image. In the superposition image, an analysis region is determined. Thereby, even when the light detected in a luminescence observation is feeble, a luminescent cell and/or a luminescent site in a cell in a sample can be specified.09-02-2010
20120138820System and method for detecting and visualizing ignitable liquid residues using hyperspectral imaging - The present disclosure provides for a system and method for detecting, identifying and/or distinguishing between ignitable liquid residues on various types of substrates. A method may comprise generating a fluorescence data set representative of a substrate, which may comprise a fluorescence hyperspectral image. This fluorescence data set may be analyzed to determine the presence and/or identity of an ignitable liquid residue. Regions of a substrate comprising an ignitable liquid residue may further be interrogated using Raman techniques. This may comprise generating and analyzing a Raman data set representative of a region of interest of a substrate to thereby identify an ignitable liquid residue. A system may comprise an illumination source, a tunable filter, and a first detector configured to generate a fluorescence data set. The system may further comprise a second detector configured to generate a Raman data set representative of a region of interest of a substrate.06-07-2012
20120193552FLUORESCENCE LIFETIME IMAGING - A method of measuring fluorescence from a location, the method comprising applying to the location a first fluorescence excitation signal having a first duty cycle, accumulating as a first result fluorescence that emanates from the location in response to the first excitation signal, applying to the location a second fluorescence excitation signal having a second duty cycle, accumulating as a second result fluorescence that emanates from the location in response to the second excitation signal, and comparing the first and second results to provide a comparison result for the location. The invention also relates to apparatus for performing the method.08-02-2012
20100252750SYSTEMS AND METHODS FOR STIMULATED EMISSION IMAGING - A microscopy imaging system is disclosed that includes a light source system, focusing optics, an optical detector and a processor. The light source system is for providing an excitation beam at a center optical frequency ω10-07-2010
20100252751MICROELECTRONIC OPIACAL EVANESCENT FIELD SENSOR - There is provided a microelectronic sensor device (10-07-2010
20100140503APPARATUS AND METHOD FOR READING FLUORESCENCE - It is an objection of the present invention to provide a fluorescence reading apparatus in view of the influence of fluorescence derived from a fluorescence substance that is not involved with an interaction between a probe substance and a target substance.06-10-2010
20130126757Methods, Systems and Apparatuses for Testing and Calibrating Fluorescent Scanners - Disclosed are calibration apparatuses for fluorescent microscopy instruments and methods of making and using them. Specifically, disclosed are calibration apparatuses with a fluorescent layer, such as photoresist, deposited on a substrate, with an optional layer of a reflective material, such as chrome. Illumination of the fluorescent and/or reflective layers, and detection and analysis of the resulting emissions allows evaluation of the instrument with respect to both reflective and fluorescent channels. Selection of appropriate fluorescent materials for the one or more fluorescent layers allows the evaluation of an instrument with respect to different fluorophores, as would be used with an instrument capable of two color detection. Inclusion of a reflective layer further allows the evaluation and calibration of all optical channels of an instrument, including the reflective channel and two or more fluorescent channels, with a single calibration apparatus for imaging criteria such as uniformity, contrast and emission signal strength.05-23-2013
20110057119Auto-synchronous fluorescence detection method and apparatus - An apparatus for time-gated fluorescence or luminescence detection includes gating means (03-10-2011
20110057118Method of Indirect Emission by Nano-materials - A method of indirect emission by nano-materials includes providing an infrared up-conversion phosphor 1 (weight ratio) and a long-wave ultraviolet phosphor 0.01-10 (weight ratio); treating both surfaces of the infrared up-conversion phosphor and the long-wave ultraviolet phosphor; mixing the infrared up-conversion phosphor and the long-wave ultraviolet phosphor; exciting the infrared up-conversion phosphor by a near-infrared laser with a wavelength of 980 mn to emit blue light as a secondary excitation lightsource; exciting the long-wave ultraviolet phosphor by the blue light to emit a visible light. Biological reactions can be conveniently detected by detecting the visible light.03-10-2011
20090289199Use of Fluorescent Nanoparticles to Measure Individual Layer Thicknesses or Composition in Multi-layer Films and to Calibrate Secondary Measurement Devices - Fluorescent nanoparticles such as quantum dots are incorporated into plastic, paper and other web layered products to achieve cross-direction and machine direction on-line analysis of the individual layers therein. Fluorescent nanoparticles markers are added in known proportions into product formulations. By detecting the fluorescence from the nanoparticles, the thickness and other physical characteristics of the web can be traced at various stages of production. In addition, by using different populations of fluorescent nanoparticles that emit radiation at different wavelengths, data from individual layers in a composite structure can be ascertained simultaneously with a single sensor. The technique is particularly suited for monitoring difficult-to-measure polymers in complex multilayer structures.11-26-2009
20090321662DETECTION METHOD, DETECTION APPARATUS, AND SAMPLE CELL AND KIT FOR DETECTION - A sensor chip includes a sensor-portion having at least a metal-layer deposited on a surface of a dielectric-plate. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection target substance in a sample binds to the sensor-portion when the sample is placed in contact with the sensor-portion. The sensor-portion is irradiated with excitation-light to generate an enhanced electric-field on the sensor-portion. The amount of the detection target substance is detected based on the amount of light generated by excitation of a fluorescent-label in the fluorescent-label binding-substance in the enhanced electric-field. A magnetic-particle is added to the fluorescent-label binding-substance, and the amount of the detection target substance is detected while the fluorescent-label binding-substance modified with the magnetic-particle is attracted to the vicinity of the sensor-portion by a magnetic-field application means arranged on an opposite-surface side of the dielectric-plate, opposite to the metal-layer-deposited surface thereof.12-31-2009
20080230717PHOTOACOUSTIC INDICATORS - A method of measuring fluorophore excited state lifetimes comprising initiating an excitation laser pulse at a dye to excite dye molecules of the dye from a ground state to an excited state and initiating a probing pulse at the dye molecules thereby generating a first set of photoacoustic waves at a first time delay resulting in a first intensity point. The process can be repeated, optionally introducing a second excitation laser pulse, to generate a second set of photoacoustic waves at a second time delay resulting in a second intensity point. The data can be analyzed to determine a slope between the first intensity point and the second intensity point.09-25-2008
20100294951Sensitive gas-phase flourimeter at ambient pressure for nitrogen dioxide - An instrument detects an amount of a component of a sample gas by passing an excitation light through the sample gas at atmospheric pressure to produce fluorescence light from the component. The fluorescence light is discriminated using a sequence of multiple long pass interference filters to filter out the excitation light. The discriminated fluorescence light is then detected to produce a signal representative of the amount of the component in the sample gas. Preferably, the excitation light is continuously passed through the sample gas. In one embodiment, the gas flows through a cell having a parabolic reflector as an interior surface and a source of the excitation light at a focus of the parabolic reflector. In other embodiments, multiple components are detected in parallel using multiple sample cells and a fiber optic multiplexer to sequentially filter and detect the fluorescence light from each of the multiple sample cells.11-25-2010
20100301231APPARATUS, METHOD AND COMPUTER PROGRAM FOR FLUORESCENCE CORRELATION SPECTROSCOPY - There are provided an apparatus, a method and a computer program for fluorescence correlation spectroscopy (FCS), which can reduce the number of times of fluorescence measurements of control samples as few as possible for a measurement by FCS in detecting existence ratios of the respective components contained in a sample. In the inventive apparatus, method and computer program for detecting an existence ratio of each of components with a fluorescent label contained in a solution sample by FCS, using a value of a ratio of a translational diffusion time of each of the components based upon the knowledge that a ratio of a translational diffusion time of each of the components is conservative under different measurement conditions etc.12-02-2010
20110127445UPCONVERSION FLUORESCENT NANO-STRUCTURED MATERIAL AND USES THEREOF - Upconversion fluorescent nano-structured material(s) comprising at least one compound of formula (M06-02-2011
20100301232LASER SCANNER APPARATUS FOR FLUORESCENCE MEASUREMENTS - The invention relates to a laser scanner apparatus (12-02-2010
20100301230METHOD AND APPARATUS FOR ULTRAVIOLET SCAN PLANNING - The invention provides method for locating one or more substantially circular-shaped tissue sample positioned on a solid support. The method involves the steps of transmitting light of a preselected wavelength onto a tissue sample, wherein the light induces the tissue sample to autofluoresce, identifying the center location of the tissue sample using the autofluoresced light, correlating the coordinates of the center location of the tissue sample on the solid support using an x, y-coordinate system, and mapping the coordinates of the tissue sample on the solid support to differentiate tissue sample containing regions from blank regions on the solid support. In a second aspect, the invention provides an apparatus for locating one or more substantially circular-shaped tissue sample positioned on a solid support.12-02-2010
20100314555OPTICAL MEASUREMENT APPARATUS, FLOW SITE METER AND OPTICAL MEASUREMENT METHOD - Disclosed herein is an optical measurement apparatus including at least: a flow channel through which samples flow; a first light radiation section; a first opto-electrical conversion section; a first analog-to-digital conversion section; a second light radiation section; a second light detection section; a second opto-electrical conversion section; an amplification section; and a second analog-to-digital conversion section.12-16-2010
20100320398FLUORESCENCE DETECTING METHOD AND FLUORESCENCE DETECTING DEVICE - Provided are a fluorescence detecting method and a fluorescence detecting device for calculating the fluorescence relaxation time constant more accurately than in the prior art when fluorescence emitted from an analyte is detected by applying laser beam. When the analyte passes the position irradiated with laser beam modulated in intensity by a modulation signal of a predetermined frequency, a first fluorescence signal of fluorescence received by a light-receiving means is collected. A second fluorescence signal of the fluorescence received by the light-receiving means is collected in a state in which the analyte is not in the position irradiated with the laser beam after the analyte has passed the position irradiated with the laser beam. Phase difference information of a fluorescence signal of the fluorescence emitted from the analyte with respect to the modulation signal of the laser beam is obtained by using the collected first fluorescence signal and second fluorescence signal, and the fluorescence relaxation time constant of the fluorescence emitted from the analyte is obtained from the obtained phase difference information of the fluorescence signal of the fluorescence emitted from the analyte.12-23-2010
20100243916MODULAR OPTICAL DIAGNOSTIC PLATFORM FOR CHEMICAL AND BIOLOGICAL TARGET DIAGNOSIS AND DETECTION - A modular system for optical diagnosis of a sample includes a portable optical probe, a light source, a filter, and a gain detector. A first optical element releasably, optically couples the optical probe to the light source. A second optical element releasably, optically couples the optical probe to the filter and a third optical element releasably, optically couples the filter to the gain detector. The optical probe receives an optical signal from the light source via the first optical element and directs the optical signal onto the sample, thereby inducing fluorescence emission from the sample. The optical probe receives the fluorescence emission from the sample and transmits to the filter via the second optical element. The filter transmits the fluorescence emission to the gain detector via the third optical element. The optical head includes a beam splitter which reflects the fluorescence emission from the sample to the filter.09-30-2010
20110108739METHOD FOR THE OPTICAL DETERMINING OF A MEASURED VARIABLE OF A MEDIUM - In a method for determining a measured variable of a measured medium, wherein the measured medium is brought in contact with an indicator or an indicator mixture, whose absorption spectrum has a first, and a second, wavelength range, which essentially do not overlap,05-12-2011
20120032093TAGGED SCALE INHIBITOR COMPOSITIONS AND METHODS OF INHIBITING SCALE - Scale inhibitor compositions and methods of inhibiting scale formation generally include a tagged scale inhibiting (co)polymer including at least one scale inhibiting moiety and an imidazole moiety. The imidazole moiety fluoresces at a wavelength of about 424 nm and can be used to detect the amount of scale inhibitor present.02-09-2012
20110031413METHOD OF LUMINESCENT SOLID STATE DOSIMETRY OF MIXED RADIATIONS - A method of determining the doses of neutrons, gamma and X-ray photons, beta, alpha and other ionizing radiations using a method of image processing in spatial and frequency domain that produces parameters that are related to the radiation dose absorbed in a luminescent material. Portions of the luminescent material may be covered by different converters to allow for doses of different radiations to be discriminated.02-10-2011
20110031414DEVICE FOR MICROSCOPY HAVING SELECTIVE ILLUMINATION OF A PLANE - A microscopy device, particularly for use in an imaging fluorescence lifetime microscopy method is provided. The microscopy device comprises an illumination means for generating an illumination beam, an imaging detector for spatially resolved acquisition of an emission radiation emitted by an object to be examined, an illumination beam path between the illumination means and the object to be examined, and a detection beam path between the object to be examined and the detector. The illumination beam path comprises illumination optics which are designed to generate a light sheet of illumination radiation extending transverse to the axis of the illumination beam path, wherein the axis of the detection beam path is oriented substantially perpendicular to a section plane of the light sheet and of the object to be examined. The illumination means comprise a pulsed laser.02-10-2011
20110031411Superresolution in devices with single wavelength illumination - In apparatus for superresolution microscopy or microlithography, wherein a spot in the specimen to be examined or in the microlithographic medium is raised to an excited state by a first pulse of light, and a second pulse of light reduces the excitation in the peripheral parts of the spot to increase the resolution of the instrument, a method whereby the wavelength of the second pulse in the specimen or medium is the same as the wavelength of the first pulse, thereby allowing the cost and complexity of the apparatus to be lowered.02-10-2011
20110036996APPARATUS AND METHOD FOR HIGH SPATIAL RESOLUTION IMAGING OF A STRUCTURE OF A SAMPLE - Apparatus and method for high spatial resolution imaging of a sample's structure, including a diffraction-limited resolution volume with a plurality of dye molecules which can be switched between different states and have a distribution density which is greater than the inverse of the diffraction-limited resolution volume, where at least one state is fluorescing, the fluorescence being collected by an objective lens and imaged on a spatially resolving detector by an optical system. At least one light source provided for emitting a switching radiation and for emitting an excitation radiation. At least one of the light sources is arranged to radiate through the sample, and a switching and/or fluorescence excitation of the dye molecules is carried out. The switching is a photoactivation or a photodeactivation of the dye molecules. A focusing arrangement is provided for switching and/or for excitation to generate a line-like illumination region extending in a direction of illumination.02-17-2011
20110114854SLIDE TRANSFER MECHANISM FOR A LASER SCANNER DEVICE - A slide transfer mechanism for a laser scanner device (05-19-2011
20100171043SINGLE ELEMENT SENSOR WITH MULTIPLE OUTPUTS - An analyte sensor is described. The sensor employs a single sensor element which provides a plurality of phase outputs in response to excitation by a modulated excitation source. The plurality of phase outputs may be analysed to provide information on the presence of one or more analytes.07-08-2010
20100163747VALUABLE DOCUMENT - The invention relates to a printed value document having at least one luminescent substance.07-01-2010
20100163748DUAL DETECTOR CAPILLARY WAVEGUIDE BIOSENSOR AND METHOD FOR USE THEREOF - A method for fluorescence detection that provides control of experimental and molecular factors and reliably predicts of concentration from fluorescence intensity measurements utilizing capillary-based flow sensors utilizing a dual detector approach to provide instantaneous normalization of the fluorescent intensity by the Rayleigh scattered intensity measured from the same sensing volume, insensitive to various experimental parameters for prediction of absolute concentrations of fluorescent solutes.07-01-2010
20100224796Imaging System Using Dynamic Speckle Illumination - A versatile, imaging system that uses dynamic speckle illumination (DSI) is disclosed. The DSI microscope includes at least one light source for producing light to illuminate a target object in an object plane; an image recording device for recording a sequence of images of the target object; imaging optics for transmitting signal light from the target object as the sequence of images from the target object to the image recording device; and a dynamic speckle generating system for illuminating the target object with dynamic speckle.09-09-2010
20110240885Broadband Solid-State Illuminator for Fluorimetry Device and System - An improved solid-state light source (10-06-2011
20100193704FLUORESCENCE EXCITATION AND DETECTION SYSTEM AND METHOD - An excitation and detection system is provided for separately detecting different wavelengths of emission light emitted from a sample. The system comprises an excitation assembly to excite a sample and a detection assembly to receive fluorescence emitted from the sample. The detection assembly includes a multi-band dichroic member and at least first and second detection cameras. The multi-band dichroic member has a transmission/reflection characteristic with at least two transmissive regions separated from each other along the wavelength spectrum and with at least one reflective region separated from the transmissive regions along the wavelength spectrum. The dichroic member transmits fluorescence that aligns with the at least two transmissive regions to the first detection camera. The dichroic member reflects fluorescence that aligns with the reflective region to the second detection camera. The dichroic member multiplexes the detection of fluorescent signals without the use of a filter wheel in the detection assembly. The components of the detection assembly remain stationary throughout imaging of multiple colors, for example therefore allowing the use of two detectors to record images of three or more colors without the need for filter wheels or other moving components.08-05-2010
201201459263D IMAGING OF LIVE CELLS WITH ULTRAVIOLET RADIATION - A method for 3D imaging of cells in an optical tomography system includes moving a biological object relatively to a microscope objective to present varying angles of view. The biological object is illuminated with radiation having a spectral bandwidth limited to wavelengths between 150 nm and 390 nm. Radiation transmitted through the biological object and the microscope objective is sensed with a camera from a plurality of differing view angles. A plurality of pseudoprojections of the biological object from the sensed radiation is formed and the plurality of pseudoprojections is reconstructed to form a 3D image of the cell.06-14-2012
20110084218METHOD AND DEVICE FOR PARTICLE ANALYSIS USING THERMOPHORESIS - The present invention pertains to a device and method to measure thermo-optical, preferably thermophoretic, characteristics of particles in a solution. The method comprises the steps of: (a) providing a sample probe comprising marked particles in a solution; (b) providing a temperature control system for creating a temperature gradient within said sample probe by contact heating, electrical heating and/or cooling; (c) detecting the marked particles at a first time; (d) creating a temperature gradient within the sample probe by means of the temperature control system; (e) detecting the marked particles in the sample probe at a, preferably predetermined, second time and/or at a predetermined location within the temperature gradient, and (f) characterizing the particles based on said two detections.04-14-2011
20110210271Detector System For Unidentified Substances - Disclosed herein is a detection system for identifying an unidentified substance in a sample, comprising a light emitting source; a circuit board; a trigger, that activates a pulse of electrons from the circuit board to the light emitting source such that the light emitting source emits light; a detector for collecting light from the unidentified substance; and a central processing unit for analyzing the collected light to identify the unidentified substance.09-01-2011
20090218516Ratiometric Surface Plasmon Coupled Emission Detector - The present invention includes methods for ratiometric detection of analytes by surface plasmon coupled emission detection that includes disposing a target on the metal layer of a surface plasmon resonance detection system; coupling a first analyte to a first fluorescent dye and a second analyte to a second fluorescent dye; contacting the first and second analytes to the target on the surface plasmon resonance detection system; and measuring the intensity of a first and a second surface plasmon resonance enhanced fluorescence emission ring, wherein the first and second rings, respectively, quantitatively represents the amount of first and second analyte within 50 nanometers of the metal surface.09-03-2009
20090218515ELIMINATING FLUORESCENCE BACKGROUND NOISE - A method for measuring a fluorescent sample on a substrate. The method includes exciting the fluorescent sample with an exciting light source for the generation of a sample fluorescent optical signal and a substrate fluorescent optical signal substantially eliminated. The microfluidic substrate fluorescent optical signal is leaving the sample fluorescent optical signal. The sample fluorescence optical signal can then be processed.09-03-2009
20090218517MULTIPLEX FLUORESCENCE DETECTION DEVICE HAVING REMOVABLE OPTICAL MODULES - Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules. Each of the removable optical modules is optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector.09-03-2009
20090218514MULTI-SPOT INVESTIGATION APPARATUS - The invention relates to a method and an apparatus for the investigation of a sample material by multiple sample light spots (09-03-2009
20090032734Detection of microorganisms with a fluorescence-based device - A device and method for detecting by fluorescence microbial growth from sample substances are disclosed. For example, a method for the detection of visible-band fluorescence signals generated by at least one fluorescing compound excited by ultraviolet energy, comprising exciting said at least one fluorescing compound with ultraviolet energy emitted from a light-emitting diode comprising wavelengths below 400 nanometers, and detecting a visible-band fluorescence signal generated by said at least one excited fluorescing compound with at least one light detector sensitive to electromagnetic energy comprising wavelengths greater than or equal to 400 nanometers wavelength. For example, a device for detecting visible-band fluorescence signals generated by at least one fluorescing compound excited by ultraviolet energy, comprising at least one ultraviolet light-emitting diode generating electromagnetic radiation comprising wavelengths below 400 nanometers and capable of exciting the at least one fluorescing compound, at least one light detector sensitive to electromagnetic energy comprising wavelengths greater than or equal to 400 nanometers wavelength for the detection of visible-band fluorescence signals generated by the at least one fluorescing compound.02-05-2009
20090032736Biochip reader and fluorometric imaging apparatus - The present invention provides a biochip reader for reading the image information of samples using a photodetector device, by irradiating a corresponding beam of excitation light at each site of a biochip on which a plurality of the samples are arranged at equal pitches, the biochip reader comprising: a microlens substrate provided with a plurality of microlenses to transform excitation light to be irradiated at the biochip into a multibeam; and a zoom lens located between the microlens substrate and the biochip and capable of projecting the multibeam while adjusting the pitch between sites of the biochip to the pitch of the multibeam. The present invention further provides a fluorometric imaging apparatus for detecting the image of a specimen by irradiating excitation light at samples on the specimen arranged in a two-dimensional manner and measuring fluorescent light produced from a fluorescent substance attached to the specimen, the fluorometric imaging apparatus comprising: a two-dimensional photodetector device for detecting excitation light passing through the specimen or reflecting off the surface thereof; and movement means for repositioning the specimen according to images observed on the photoreceptor device.02-05-2009
20090032735Sensing Device, Sensing Apparatus, and Sensing Method - There are provided a sensing device, a sensing apparatus, and a sensing method capable of realizing effective multi-photon absorption and local plasmon enhancement function. The sensing device can realize a high multi-photon excitation efficiency and selectivity by accurately controlling the material, shape, size, interval, and direction of metal particles arranged on a substrate. By employing the sensing device in various sensing apparatuses such as a fluorescent sensing apparatus, it is possible to realize sensing of detection object material with a high sensibility.02-05-2009
20120241646POLYMER-CONJUGATED QUANTUM DOTS AND METHODS OF MAKING THE SAME - The present application relates to polymer-conjugated quantum dots. The quantum dots can include, for example, an inorganic core conjugated to a polymer. The quantum dots may, in some embodiments, be water-soluble and exhibit superior photoluminescence. Also disclosed are methods of making and using the quantum dots.09-27-2012
20110174987Spectroscopic Device, and Method for Driving the Device - Provided is a spectroscopic device of a new constitution, which is suited for detecting precisely a fluorescent light emitted from an inspection object in a fluorometric analysis, such as a DNA. The spectroscopic device (07-21-2011
20110101240FLUORESCENT INK COMPOSITIONS COMPRISING FUNCTIONALIZED FLUORESCENT NANOCRYSTALS - A fluorescent ink composition comprising functionalized fluorescent nanocrystals, an aqueous-based ink carrier comprising water or a water-based solution, and a binder. Also provided are methods of providing an image or a security mark on a substrate for subsequent identification by applying a fluorescent ink composition onto the substrate.05-05-2011
20110101241Solid-State Photodetector Pixel and Photodetecting Method - A pixel is formed in a semiconductor substrate (S) with a plane surface for use in a photodetector. It comprises an active region for converting incident light (In) into charge carriers, photogates (PGL, PGM, PGR) for generating a lateral electric potential (Φ(x)) across the active region, and an integration gate (IG) for storing charge carriers generated in the active region and a dump site (Ddiff). The pixel further comprises separation-enhancing means (SL) for additionally enhancing charge separation in the active region and charge transport from the active region to the integration gate (IG). The separation-enhancing means (SL) are for instance a shield layer designed such that for a given lateral electric potential (Φ(x)), the incident light (In) does not impinge on the section from which the charge carriers would not be transported to the integration gate (IG).05-05-2011
20110068280DEVICE AND METHOD FOR SPATIAL RECONSTRUCTING OF FLUORESCENCE MAPPING - The invention concerns a method for locating at least one fluorophore or at least one absorber in a diffusing medium, using at least one excitation radiation and at least one fluorescence detector (Φ03-24-2011
20120119111METHOD AND APPARATUS FOR READING OUT IMAGE INFORMATION STORED IN A STORAGE PHOSPHOR OF A STORAGE MEDIUM - A method for reading out image information stored in a storage phosphor of a storage medium includes moving a light beam over the storage medium. A luminescence signal is generated by the photostimulation of the storage phosphor. In first time intervals a respective output value is determined from the luminescence signal, and a respective pixel value of an image pixel of a digital image is determined from the output value. The output value is thereby determined by addition of a plurality of measurement values of the luminescence signal which are detected in second time intervals lying within the first time interval. A corresponding apparatus for carrying out the method is described as well.05-17-2012
20120119110APPARATUS, AND ASSOCIATED METHOD, FOR DETECTING CONTAMINATION OF AN OBJECT - An apparatus, and an associated method, for a portable electronic device, such as a wireless device, to determine luminescence of an object of interest. Ultraviolet A (UVA), or other appropriate, light energy is cause to be generated at a flicker rate. Images of the object of interest are recorded both when the UVA light energy is incident on the object of interest and in the absence of incidence of the UVA light energy on the object of interest. The images are compared, and a determination is made of the luminescence of the object of interest.05-17-2012
20110042583OBSERVATION CHAMBER FOR STUDYING TEMPERATURE-DEPENDENT EVENTS AND METHOD THEREOF - Live-cell imaging chambers are used in a wide range of cell biology research. Recently, chambers capable of taking high-resolution and time-lapse images of live cells have been developed and become commercially available. However, since most of these chambers are designed to maintain a thermally stable environment for the cells under study, it is usually very difficult to use them to study temperature-dependent cellular events. The present invention provides a live-cell observation equipment for a non light-transmitting microscope to study temperature-dependent events and method thereof.02-24-2011
20110031410METHOD FOR MEASURING FLUORESCENT LIGHT AMOUNT OR LIGHT ABSORPTION AMOUNT AND DEVICE FOR MEASURING THE SAME - An amount of fluorescent light generated from the specimen is quantitatively measured as “a light-amount value per unit area traceable to the national standard” instead of in terms of a ratio (a ratio value) as in the past. A method for measuring a fluorescent light amount, whereby a specimen is irradiated with excitation light, and fluorescent light generated from the specimen is measured by a light-receiving element via a receiving optical system, said method comprising the steps of irradiating the specimen with excitation light having a light-amount value per specified unit area traceable to the national standard, and designated on the surface of the specimen beforehand, causing the light-receiving element to measure the fluorescent light generated from the specimen via the receiving optical system, and computing a fluorescent light-amount as measured by the light-receiving element via the receiving optical system on the basis of an excitation light-amount per the specified unit area, optical coefficients of the receiving optical system, and the acceptance coefficient of the light-receiving element, thereby working out a light amount value per the unit area traceable to the national standard.02-10-2011
20110049390Method and Apparatus for Detection of Bioaerosols - A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.03-03-2011
20110042585FIBER OPTICAL ASSEMBLY FOR FLUORESCENCE SPECTROMETRY - System and method for analyzing a sample for the presence of an analyte in a sample, the system comprising a sample holder for containing the sample; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed to the sample, and wherein the radiation induces a fluorescence signal; and at least one linear array comprising a proximal end disposed in proximity to the sample holder and an end port distal from the proximal end; a plurality of optical fibers extending from the proximal end to the end port and having a first end and a second end, wherein the first ends of the individual optical fibers are substantially coplanar and adjacent to one another, and wherein the second ends of the optical fibers form a non-linearly arranged bundle, and wherein the plurality of optical fibers transmits the fluorescent signal from the proximal end to the end port; and an end port assembly optically coupled to the end port, the end port assembly comprising a single photo-detector, wherein the photo-detector detects the fluorescent signal and converts the fluorescent signal into an electrical signal.02-24-2011
20110042584DEVICE FOR DETERMINING THE CONVERSION POWER - This invention relates to a device for determining the conversion power of conversion element, a method for performing these measurements and a method for producing pcLEDs with essentially the same color point applying said device and said method. The device comprises a light source (02-24-2011
20110024648LUMINESCENT COMPOUNDS - The subject of the invention is a compound chosen from compounds of formula Y02-03-2011
20100001208METHOD FOR QUANTITATIVE DETERMINATION OF THE SUITABILITY OF CRYSTALS FOR OPTICAL COMPONENTS EXPOSED TO HIGH ENERGY DENSITIES, CRYSTALS GRADED IN THIS WAY AND USES THEREOF - A method is described for quantitative determination of suitability of an optical material, especially alkali halide and alkaline earth halide single crystals, for optical components exposed to high energy densities, especially of pulsed laser light at wavelengths under 250 nm. In this procedure radiation-dependent transmission of the optical material is determined at ultraviolet wavelengths by fluorescence measurements for fluorescence induced by ultraviolet radiation at these ultraviolet wavelengths. This is accomplished by a method including determining an induced fluorescence maximum of a non-linear absorption process, measuring a slope (|dT/dH|) of a functional relationship representing the dependence of the radiation-dependent transmission on fluence (H) for the induced fluorescence and determining radiation-dependent transmissions from this slope for particular fluence values.01-07-2010
20100264334EXCITATION-INTENSITY-DEPENDENT, COLOR-TUNABLE, DUAL EMITTING NANOCRYSTALS - An embodiment of the invention is a device for photo-stimulated color emission having at least one plurally doped semiconducting nanoparticle comprising at least one semiconducting material and a plurality of at least one dopant coupled with an irradiation source such that the plurally doped semiconducting nanoparticle emit electromagnetic radiation at two or more wavelengths where the intensities of the emissions depend on the intensity of the irradiation. In an embodiment of the invention, the plurally doped semiconducting nanoparticle can be a doped core/shell nanoparticle where the plurality of dopants can reside in exclusively the core, exclusively the shell, or in both the core and shell.10-21-2010
20090294691Method for Improving the Detection of Fluorescence Signals During a Resonance Energy Transfer - The invention concerns the use of the fluorescence polarization phenomenon to improve detection of fluorescent signals during a fluorescence resonance energy transfer (FRET). In particular, the invention concerns a method for improving signal/noise ratio in a FRET measurement. The invention also concerns an apparatus for measuring fluorescence following an energy transfer between a donor fluorescent compound and an acceptor fluorescence compound in a measurement medium.12-03-2009
20080315119Method of Analysing a Sample and Apparatus Therefor - A method for performing photo-modification of a biological sample, the method comprising: (a) irradiating the sample; (b) detecting one or more signals based on the irradiated sample; (c) using one or more processor means to analyze the detected signals and determine one or more irradiation parameters, and, (d) returning to (a) conditioned on the irradiation parameters. Thus modifications may be determined and executed interactively as an experiment progresses, and therefore directed towards specific structures and/or events identified as of particular interest in the course of the experiment.12-25-2008
20110174988METHOD AND APPARATUS FOR QUANTITATIVE EVALUATION OF WALL ZETA-POTENTIAL, AND METHOD AND APPARATUS FOR QUANTITATIVE VISUALIZATION OF SURFACE MODIFICATION PATTERN - A first and a second fluorescent dye are mixed into a solution, the first dye being positively ionized in the solution and the second dye being negatively ionized in the solution and having different fluorescence wavelength from the first dye. The solution is flown onto a measured surface, and the surface is excited with an evanescent wave to produce a fluorescence intensity distribution of two colors. A fluorescence intensity of the surface is measured using a two-dimensional imaging element, the element providing a fluorescence intensity of each color separated from the other colors, thereby calculating a ratio of the fluorescence intensities of the colors. Using an equation expressing a relationship between the ratio of fluorescence intensities and wall zeta potential, the ratio is converted to a two-dimensional distribution of wall zeta potentials. This achieves visualizing in real time and quantitatively evaluating the two-dimensional distribution of wall zeta potentials, and surface modifications.07-21-2011
20080203319Multicapillary Multilaser Detection System - A system for detecting electromagnetic radiation from samples comprising: a plurality of sample volumes, each of said sample volumes confined within a portion of a capillary column; a plurality of electromagnetic radiation sources; a mirror for receiving electromagnetic radiation from the electromagnetic radiation sources and for reflecting the electromagnetic radiation to the sample volumes; a scanner attached to the mirror; a parabolic reflector for collecting sample electromagnetic radiation from the sample volumes, the sample electromagnetic radiation being generated as a result of interaction of the reflected electromagnetic radiation with the sample volumes; a plurality of filters for filtering the sample electromagnetic radiation; and a plurality of detectors for detecting sample electromagnetic radiation from the sample volumes, each of the detectors being configured to receive sample electromagnetic radiation that has passed through a corresponding one of the plurality of filters and generate a signal upon receipt of sample electromagnetic radiation.08-28-2008
20100282982DEVICE FOR MEASURING THE FLUORESCENCE OF A MEDIUM - A device for measuring the fluorescence of a medium having a radiation source, an emission-receiving element and an optical imaging element arranged on the sensor side of the optical imaging element, and a scattering-receiving element arranged on the sensor side of the optical imaging element and in which the radiation source, the imaging element and the emission-receiving element are aligned and configured relative to one another so that the medium present on the medium side of the imaging element can be illuminated by radiation from the radiation source, and the emission intensity of the medium radiation emitted by the medium based on fluorescence can be detected with the emission-receiving element. To provide a device for measuring the fluorescence of a medium which has an increased reliability in measuring the fluorescence, temperature compensation is performed relative to the temperature of the medium and/or at least one of the receiving elements.11-11-2010
20110068279ULTRA DARK FIELD MICROSCOPE - A fluorescence microscope includes a nearly monochromatic light source, a Brewster angle wedge, and an optical system for irradiating a sample with a light beam from the light source and directing fluorescence light from said sample onto the Brewster angle wedge. Collection optics are provided for focusing a hyper-spectral, wide angle and dark field image of the sample from the Brewster angle wedge onto recording optics.03-24-2011
20100181496IN-SITU PLANT ANALYSIS APPARATUS, METHOD FOR TRACKING THE STATE OR EVOLUTION OF A CULTURE AND METHOD FOR MANAGING VEGETABLE PROCESSING - A device for analyzing plants, by luminous excitation and fluorescence measurement, can be used on site without preparation of the plants. The device evaluates the content of a compound in the skin or epidermis of a plant. The geometry of the device is characterized by a direction of the excitation light rays and a direction of the fluorescence light rays which are non-collinear with each other. The device includes several sets of emitters of different wavelengths, each including several emitters, and makes it possible to measure a plurality of excitation-fluorescence combinations. A method for evaluating and monitoring the development and maturity of a crop, as well as a method for monitoring and controlling plant treatment are also described.07-22-2010
20100181497OPTICAL MICROSCOPY WITH PHOTOTRANSFORMABLE OPTICAL LABELS - An apparatus includes a position-sensitive detector to detect intensities of radiation as a function of position on the detector, and an optical system, characterized by a diffraction-limited resolution volume, adapted for imaging light emitted from activated and excited phototransformable optical labels (“PTOLs”) in a sample onto the position sensitive-detector. A first light source provides activation radiation to the sample to activate a subset of the PTOLs that are distributed in the sample with a density greater than an inverse of the diffraction-limited resolution volume of the optical system. A second light source provides excitation radiation to the sample to excite a portion of the PTOLs in the subset of the PTOLs. A controller controls one both of the activation radiation and the excitation radiation provided to the sample such that a density of PTOLs in the portion of the PTOLs is less than the inverse of the diffraction-limited resolution volume.07-22-2010
20100117003METHOD FOR THE QUANTITATIVE DETERMINATION OF THE CONCENTRATION OF FLUOROPHORES OF A SUBSTANCE IN A SAMPLE AND APPARATUS FOR CARRYING OUT THE SAME - The invention concerns a method and an apparatus for the quantitative determination of the concentration of fluorophores of at least one substance in a sample. A constant portion of the reference light of a reference light wave length (λr) emitted by a reference light source (05-13-2010
20120145925PHOTOFRAGMENTATION-LASER-INDUCED FLUORESCENCE FOR DETECTION OF NITRIC OXIDE-BEARING EXPLOSIVES - A method for identifying a presence of a nitro (NO)-bearing compound suspected of being included in a sample includes photodissociating a sample into one or more fragments that include a NO molecule, where the NO molecule has an electron in a first-vibrational excited state of an electronic ground state. Laser-induced fluorescence (LIF) is applied including directing UV light from a UV laser source at the sample to induce fluorescent light. An emission wavelength of 270 nm to 274 nm from fluorescent light received is used to identify a presence of the NO-bearing compound in the sample.06-14-2012
20110095203COLOR PROCESSING APPARATUS AND COLOR PROCESSING METHOD - A color processing apparatus according to the present invention is a color processing apparatus that calculates spectral reflectance including a fluorescent component in a sample under a target illuminant. The color processing apparatus includes first means for inputting, for each of a plurality of waveform types, spectral radiance including an excitation wavelength region and the amount of fluorescence in the sample corresponding to the spectral radiance; second means for determining, from spectral radiance of the target illuminant including the excitation wavelength region and the input spectral radiance and amount of fluorescence, the amount of fluorescence in the sample under the target illuminant; third means for inputting spectral reflectance excluding the fluorescent component in the sample; and fourth means for determining, by using the determined amount of fluorescence in the sample under the target illuminant and the input spectral reflectance excluding the fluorescent component in the sample, spectral reflectance including the fluorescent component in the sample under the target illuminant.04-28-2011
20110095204Method and apparatus for measuring the phase shift iduced in a light signal by a sample - A first light source emits a light signal along a measurement optical path that includes a sample and a second light source emits a light signal along a dummy measurement optical path. A measurement circuit receives the light signals and provides outputs separated in time which are indicative of the phase of the respective light signals. A phase shift is induced in light in the measurement optical path by the sample. A reference circuit receives a signal indicative of the phase of the light signals emitted by the first and second light sources. Circuitry compares the phases of light output from the two circuits to provide output indicative of a first measured phase difference during operation of the first light source. Correction is applied to this measurement by taking a similar phase difference measurement during operation of the second light source and comparing the two phase differences.04-28-2011
20120205553PHOTOLUMINESCENT MARKINGS WITH FUNCTIONAL OVERLAYERS - A photoluminescent marking that includes a photoluminescent layer and at least one functional overlayer is disclosed. The photoluminescent layer comprises at least one type of photoluminescent material. The at least one functional overlayer is adapted to selectively filter wavelengths of radiation to enhance the daylight observability of a final emission signature of the marking or to prevent the observability with the naked eye of a printed message on the marking. Also methods of making and using the inventive photoluminescent marking are disclosed.08-16-2012
20100059690FLUOROSCOPIC DEVICE AND FLUOROSCOPIC METHOD - A lesion can be made distinctive in an acquired fluorescence image so as to allow for accurate diagnosis. There is provided a fluoroscopic device (03-11-2010
20110186753METHOD AND APPARATUS FOR DETERMINING THE PRESENCE OF OPTICAL BRIGHTENERS IN WATER SAMPLES - An apparatus and method for making quantitative measurements of the amounts of optical brighteners in water samples using fluorescence measurements at multiple wavelengths. First and second emission wavelength raw measurements are corrected for sample absorption to provide absorption-corrected first emission wavelength and second emission wavelength fluorescence emission values. The absorption-corrected first emission wavelength value is compared to the absorption-corrected second emission wavelength value and to similarly-determined and similarly absorption-corrected emission wavelength values or a ratio thereof obtained from a comparison water sample in which optical brighteners are not present or are only minimally present, to provide a quantitative optical brightener measurement. The apparatus and method may be field-based or laboratory-based, and may operate on a flow-through basis or on discrete samples.08-04-2011
20110186754Device for the Optical Imaging of a Sample - In a device for the optical imaging of a sample, having at least one light source for excitation light in order to excite a fluorescent dye in a sample, which is held by a sample holder, for spontaneous emission of fluorescent light over a limited period of time in a spatial region having increased resolution, and for de-excitation light in order to de-excite the fluorescent dye again except for a residual zone that is reduced in size relative to the spatial region, wherein light from the sample having wavelengths other than those of the excitation light and of the de-excitation light is assignable to the spontaneous emission of fluorescent light from the residual zone of the spatial region (STED, GSD, etc.), the de-excitation light (08-04-2011
20110215258Method and Arrangement for Collimated Microscopic Imaging - A method and arrangement for collimated microscopic imaging, including a first illumination of a sample in at least one region for exciting fluorescence, and a spatially resolving detection of the sample light by detector elements, the detection being associated with the region, wherein by means of a second illumination a sub-division of the region into separate fluorescent partial regions occurs, which are associated with the detector elements. The separation of the partial regions is carried out by the spatial separation of the fluorescent regions by means of intermediate regions having reduced fluorescence or no fluorescence, and/or by means of different spectral properties of the fluorescence from the partial regions.09-08-2011
20100019170THREE-DIMENSIONAL IMAGING USING A FLUORESCENT MEDIUM - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth.01-28-2010
20090206277Nanoparticles as agents for imaging finger prints - This invention relates to a novel analytical method for detecting prints, for example fingerprints, and to nanoparticles suitable for conducting such methods.08-20-2009
20100187439Fluorescent Monitoring Of Microcapsule Oxidation - The present disclosure relates to microcapsules that include a shell material and a core material. The core material of the microcapsules contains an environmentally sensitive luminescent colorant which exhibits characteristics of an emitted wavelength bandwidth, a peak intensity for emission and a time for luminescence decay, one or more of the characteristics capable of changing upon exposure to a given environment, and a luminescent standard which exhibits characteristics of an emitted wavelength bandwidth, a peak intensity for emission and a time for luminescence decay, one or more of the characteristics do not change upon exposure to said given environment.07-29-2010
20100264333Gas Sensing Device - The present invention relates to a gas sensing device comprising a nanoparticle layer (10-21-2010
20120037818SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIA FOR OBTAINING THREE-DIMENSIONAL INFORMATION FROM TWO-DIMENSIONAL FLUORESCENCE EMISSION DATA - Exemplary embodiments of a computer-accessible medium, method and system for providing information are provided. A first detection arrangement can be provided which can be configured to detect electro-magnetic radiations from a fluorescent particle(s) in a portion of a structure, and generate information associated with the portion of the structure. A second arrangement can be configured to generate a two-dimensional image and/or a three-dimensional image of the at least one portion of the structure as a function of the information. The electro-magnetic radiations can have different wavelengths.02-16-2012
20090101838Ionizing-radiation-responsive compositions, methods, and systems - A method, composition and system respond to ionizing radiation to adjust biological activity. In some approaches the ionizing radiation is X-ray or extreme ultraviolet radiation that produces luminescent responses that induce biologically active responses.04-23-2009
20110147616COHERENT NONLINEAR MICROSCOPY SYSTEM AND METHOD WITH VARIATION OF THE FOCAL VOLUME IN ORDER TO PROBE THE NANOSTRUCTURE OF ORGANIZED MATERIALS - A method for the dimensional characterization of a structured material, in which method: an excitation laser beam suitable for coherent nonlinear microscopy is generated, this excitation laser beam being focused in a focal volume within the structured material; signals emitted by the structured material are detected; a plurality of emission patterns, each corresponding to one particular shape of the focal volume, is produced, the particular shapes being obtained for various non-Gaussian spatial profiles of the excitation laser beam wavefront; and on the basis of the emission patterns thus produced, dimensional characteristics of the structured material are deduced therefrom.06-23-2011
20120032095METHOD AND APPARATUS FOR DETECTING PHARMACEUTICALS IN A SAMPLE - A method and apparatus for measuring a vitamin K antagonizing anticoagulant present in a sample (02-09-2012
20120032094PROCESSING A FLUORESCENCE IMAGE BY FACTORIZING INTO NON-NEGATIVE MATRICES - A method for locating at least one fluorescent tag in a scattering medium, wherein: a) at least one tag is introduced into the medium, b) a fluorescence image is performed by an infrared excitation of the medium along a first axis, the image including a fluorescence component due to the tag, and an auto-fluorescence component due to a medium part other than the tags, c) the image is processed by factorizing into two non-negative matrices, and d) an image of the distribution of the tag(s) is determined, without the auto-fluorescence component.02-09-2012
20100012853METHOD FOR PRE-IDENTIFICATION OF SPECTRAL OVERLAPS WITHIN FLUORESCENT DYE AND DETECTOR COMBINATIONS USED IN FLOW CYTOMETRY - This invention relates to the field of flow cytometry. It provides methods for identifying important dye-detector spectral overlaps for use in designing flow cytometry experiments. It further provides methods for quantifying the impact of spectral overlaps on dye selection and detector selection, the methods including the steps of: a) obtaining spectra of a dye; b) obtaining a laser configuration and an optical filter configuration of a detector; c) obtaining a spectrum yield value; and d) ranking the spectrum yield value.01-21-2010
20090230322FLUORESCENCE BASED DETECTION OF SUBSTANCES - A method for the fluorescent detection of a substance, the method comprising providing particles comprising a metal or a metal oxide core, wherein one or more optionally fluorescently tagged antibodies or human specific peptide nucleic acid (PNA) oligomers for binding to a substance is/are bound, directly or indirectly, to the surface of the metal or metal oxide; contacting a substrate, which may or may not have the substance on its surface, with the particles for a time sufficient to allow the antibody/PNA oligomer to bind with the substance; removing those particles which have not bound to the substrate; if the antibodies or PNA oligomers are not fluorescently tagged, contacting the substrate with one or more fluorophores that selectively bind with the antibody and/or substance, then optionally washing the substrate to remove unbound fluorophores; and illuminating the substrate with appropriate radiation to show the fluorophores on the substrate.09-17-2009
20120145924FLUORESCENCE EMISSIONS DETECTOR - A light source is gated ON and OFF in response to a pulsed signal. Photo emissions from the light source are coupled to a material under test. Resonant fluorescent emissions from the material are coupled to a photodiode. Current from the photodiode is coupled into an amplifier system comprising a first and second amplifier stages. The first amplifier stage is gated to a low gain when the light source is turned ON and the gain is increased when the light source goes from ON to OFF. The second amplifier stage has digitally programmable offset and gain settings in response to control signals. The output of the second amplifier stage is digitized by an analog to digital converter. A controller generates the pulse control signal and the control signals.06-14-2012
20120305802Nanoparticles and Methods of Generating Coherent Emission Therefrom - Nanoparticles with a metal or metallic core and an outer shell comprising a matrix and a dopant. For example, a nanoparticle can have a gold core and outer shell comprising silica and an organic dye. Such nanoparticles can have use in, for example, optical communication applications, chemical and biosensing applications, and imaging applications.12-06-2012
20120305803METHOD AND DEVICE FOR SETTING A SUITABLE EVALUATION PARAMETER FOR A FLUORESCENCE MICROSCOPE - A method for setting an evaluation parameter for a fluorescence microscope includes exciting dye particles in a sample to fluoresce and detecting fluorescent light from the particles. A graphical representation of a distribution of the fluorescent light is determined and a signal is generated for use in displaying the graphical representation on a display unit. Each subregion of the graphical representation is associated with a comparison value that is representative of a light quantity in the subregion. A predefined threshold is used as an evaluation parameter and compared to the comparison values. The subregions having a comparison value that is greater than the threshold value are marked on the display unit with predefined markings. The threshold value is changed and the comparison values are compared to the changed threshold value. The marked regions are defined as events and a complete image of the sample is obtained based on the events.12-06-2012
20130200277SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL - A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.08-08-2013
20100148091METHOD AND SYSTEM FOR RAPID PHASE LUMINESCENSE SPECTROSCOPY ANALYSIS - A system for use in analyzing a pharmaceutical composition having multiple constituents comprising a luminescence sensor, the sensor being adapted to direct a plurality of radiation pulses to the pharmaceutical composition and detect luminescence emitted from each composition constituent as a function of time, the sensor being further adapted to provide at least one luminescence signal corresponding to the detected luminescence of each constituent, and control means in communication with the sensor for controlling the sensor and analyzing the luminescence signal.06-17-2010
20120104281SYSTEM, METHOD, AND LUMINESCENT MARKER FOR IMPROVED DIFFUSE LUMINESCENT IMAGING OR TOMOGRAPHY IN SCATTERING MEDIA - A method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium is disclosed. The system comprises a non-linear luminescent marker material arranged in the scattering medium. Contrast and resolution of the imaging or tomography is thus improved. The non-linear marker is for instance configured to upconvert incoming light of an illumination wavelength. The non-linear power dependence of the marker enables further improvement of the imaging by using images taken with two or more excitation beams simultaneously.05-03-2012
20110315895LUMINESCENT GLASS ELEMENT, PRODUCING METHOD THEREOF AND LUMINESCING METHOD THEREOF - The present invention relates to a luminescent glass element comprising a luminescent glass substrate, which a metal layer is positioned on a surface thereof. The metal layer is provided with a metal microstructure. The luminescent glass substrate has composite oxides represented as the following formula: aM12-29-2011
20120097865Luminescence Microscopy with Enhanced Resolution - The invention is directed to a resolution-enhanced luminescence microscopy method in which a sample is excited to the emission of luminescence radiation through irradiation by excitation radiation, and an image of the luminescing sample is acquired. A first partial volume of the sample is irradiated by a first laser radiation field of the excitation radiation, and a second partial volume of the sample is irradiated by a second laser radiation field of the excitation radiation. The first partial volume of the sample and the second partial volume of the sample overlap one another partially but not completely. Only the first laser radiation field is modulated with a first frequency, and luminescence radiation is detected from the first partial volume of the sample with modulation filtering so that luminescence radiation from the second partial volume of the sample is suppressed.04-26-2012
20120043477Method for Detecting Drag Reducer Additives in Gasoline - A method for detecting polymer-based drag reducer additives in gasoline. One embodiment of the invention is a method for detecting the concentration of polymer-based drag reducer additives in gasoline, the method including the following: (a) placing a gasoline sample in a receptacle having at least two adjacent clear sides and irradiating one of the two clear sides of the receptacle with a pulsed laser beam, the pulsed laser beam having a wavelength in the ultra violet region shorter than 300 nm; (b) detecting laser-induced fluorescence wavelength resolved spectrum at 90° angle relative to the incident laser beam and through a slit defined in a diffraction screen, the diffraction screen being placed at a pre-defined first distance from the receptacle; (c) adjusting the position of the receptacle and slightly de-focusing the collimating lenses so that the low resolution fluorescence wavelength-resolved spectrum of the gasoline sample appears with a first peak at about 380 nm and a second peak at about 430 nm; (d) recording the laser-induced fluorescence wavelength-resolved spectra of the gasoline sample within a defined time-gate starting at the end of the temporal span of the laser pulse; and (e) comparing the percentage intensity of the first peak relative to the second peak for the laser-induced fluorescence spectrum near 380 nm of the gasoline sample to that of a gasoline sample free of any polymer-based drag reducer additives. In another embodiment of the method, the location of the diffraction-screen is at the pre-defined distance of between 0.5 mm to 2 mm from the side of the receptacle. In another embodiment of the method, the time-gate in step (d) is of 3 ns width and starting immediately after the end of the laser pulse.02-23-2012
20120061588FAECAL MARKERS - Described are methods for analysing an animal carcass, meat obtained therefrom, or product produced by or obtained from an animal for the presence or absence of faecal matter. The methods comprise analysing an animal carcass, meat obtained therefrom, or product produced by or obtained from the animal for the presence or absence of a detectable marker, the presence of the detectable marker being indicative of the presence of faecal matter and the absence of the detectable marker being indicative of the absence of faecal matter, wherein the animal carcass, meat obtained therefrom, or product produced by or obtained from the animal has been obtained from an animal fed a composition comprising a supplement of the detectable marker and/or a precursor thereof. Also described are compositions for feeding to an animal and for use in the methods.03-15-2012
20120153187METHOD FOR LOCATING AN OPTICAL MARKER IN A DIFFUSING MEDIUM - A method is disclosed for locating at least one optical marker in a diffusing medium, said marker having at least one optical property different from the diffusing medium, method wherein: 06-21-2012
20120001093LUMINESCENT GLASS ELEMENT, PRODUCING METHOD THEREOF AND LUMINESCING METHOD THEREOF - The present invention relates to a luminescent glass element comprising a luminescent glass substrate, which a metal layer is positioned on a surface thereof. The metal layer is provided with a metal microstructure. The luminescent glass substrate has composite oxides represented as the following formula: aM01-05-2012
20120001092LUMINESCENT GLASS ELEMENT, PRODUCING METHOD THEREOF AND LUMINESCING METHOD THEREOF - The present invention relates to a luminescent glass element comprising a luminescent glass substrate, which a metal layer is positioned on a surface thereof. The metal layer is provided with a metal microstructure. The luminescent glass substrate has composite oxides represented as the following formula: aM01-05-2012
20120001090MINUTE PARTICLE ANALYZING DEVICE AND METHOD - A minute particle analyzing device includes: a light source; a first condenser lens for condensing light from the light source to a first end of a multimode optical fiber; a second condenser lens for condensing the light emerging from a second end of the multimode optical fiber to a minute particle; and a detector for detecting light generated from the minute particle by the application of the light from the light source.01-05-2012
20110155927Non-Orthogonal Particle Detection Systems and Methods - Described herein is a particle detection system capable of spatially resolving the interaction of particles with a beam of electromagnetic radiation. Using a specific electromagnetic beam cross sectional shape and orientation, the detection sensitivity of a particle detection system can be improved. Also provided are methods for detecting and sizing particles in a manner that has low background signal and allows for spatially resolving the scattering or emission of electromagnetic radiation from particles.06-30-2011
20110155926QUANTUM EFFICIENCY MEASUREMENT APPARATUS AND QUANTUM EFFICIENCY MEASUREMENT METHOD - A sample that is an object whose quantum efficiency is to be measured, and a standard object having a known reflectance characteristic are each attached to a sample window provided in a plane mirror. Based on respective spectrums measured by a spectrometer in respective cases where the sample is attached and the standard object is attached, the quantum efficiency of the sample is measured. The plane of an opening of an observation window is made substantially coincident with the exposed surface of the sample or standard object, so that direct incidence, on the observation window, of the fluorescence generated from the sample receiving an excitation light and the excitation light reflected from sample is prevented.06-30-2011
20120061590SELECTIVE EXCITATION LIGHT FLUORESCENCE IMAGING METHODS AND APPARATUS - Imaging methods and apparatus may be applied to image tissues as well as other areas. A computer-controlled color-selectable light source is controlled to emit light having a desired spectral profile and to illuminate an area. An imaging detector images the illuminated area. The spectral profile may be selected to yield images in which contrast between features of interest and other features is enhanced. The images may be combined into a composite image. In some embodiments the spectral profile is based on a principal components analysis such that the images each correspond to one principal component.03-15-2012
20120061589METHOD AND APPARATUS FOR MEASURING FLUORESCENT MATERIAL IN A LIQUID - A method of measuring the amount of a fluorescent material in a liquid comprising the steps of exciting the fluorescent material and measuring the fluorescent response of the material over a range of wavelengths to determine a response spectrum, identifying the material from the response spectrum and determining the amount of material as a function of the amplitude of the fluorescent response and a calibration factor based upon the identification of the material.03-15-2012
20120061587DELAYED EMISSION DETECTION DEVICES AND METHODS - Embodiments of the present invention relate to a delayed emission detection device comprising a time-gated illumination source configured to provide excitation light to fluorophore during an excitation period and a light detector configured to receive emissions released from the fluorophore during a collection period after the excitation period.03-15-2012
20120061586Method and detection system for detection of aflatoxin in corn with fluorescence spectra - A system and method for fluorescence spectral imaging of target material to detect the presence of a contaminant (such as aflatoxin in corn) is provided. An ultraviolet light source is coupled a light-excluding compartment. The fluorescence from the UV excited target passes through a filter (liquid crystal tunable, acoustic-optic tunable, a filter wheel, or other wavelength splitting device) and a lens, to a spectral imaging camera. Fluorescence spectral image data from the camera is analyzed by a computer and presented in human-readable form. Aflatoxin detection in contaminated corn kernels is based on peak fluorescence and peak fluorescence shift in the spectral range from 451 nm to 500 nm. Aflatoxin contamination level within the target material is quantified based on peak fluorescence and peak fluorescence shift and computed corn kernel pixel statistics.03-15-2012
20120043479Normalization of Biomolecules - The present disclosure provides systems and methods for normalization of multiple samples, including DNA samples. The subject invention allows for decreased human error, decreased ergonomic concerns, and an increase in throughput. The subject invention provides systems and methods that allow for automated normalization of samples in multi-well plates. According to the present disclosure, a method for normalizing samples is provided. Some preferred methods comprise determining florescence data of one or more wells on a plate; electronically, using a processor, calculating dilution data for one or more of the wells on the plate based at least in part on the florescence data; and adding a liquid to the one or more wells on the plate based at least in part on the dilution data.02-23-2012
20120056103FLUORESCENCE INTENSITY COMPENSATION METHOD AND FLUORESCENCE INTENSITY COMPUTING APPARATUS - A fluorescence intensity compensation method includes emitting light onto microparticles multiply labeled with a plurality of fluorochromes having fluorescence wavelength ranges that overlap each other in order to excite the fluorochromes and receiving fluorescence generated by the excited fluorochromes using photodetectors having different reception wavelength ranges, and computing fluorescence intensities of the fluorochromes by compensating detection values of the photodetectors under a predetermined constraint condition imposed on the computed fluorescence intensities.03-08-2012
20120007001FLUOROSCOPY SYSTEM, FLUOROSCOPY APPARATUS, AND FLUOROSCOPY METHOD - Observation is performed with a fluorescence image having high quantitativeness by satisfactorily eliminating dependencies on distance and angle that remain in an image subjected to division. Provided is a fluoroscopy system 01-12-2012
20120205554AIR-STABLE, BLUE LIGHT EMITTING CHEMICAL COMPOUNDS - We report the synthesis and characterization of four novel CCC—NHC pincer platinum(II) and palladium(II) complexes, which adopt a distorted square planar configuration. These complexes emit bright blue light in the solid state under UV irradiation with emissions that are stable in ambient atmosphere (O2 and H2O) for extended periods. We also report the synthesis and characterization of CCC—NHC pincer ligand nickel complexes, and solid state fluorescence spectra have been collected for two of the complexes reported. X-ray structural analysis of a representative compound exhibits a distorted square planar geometry. Finally, we report the synthesis and characterization of CCC—NHC pincer ligand complexes for abnormal carbens, triazole, and BIA.08-16-2012
20120012756Photoluminescence Spectroscopy - This invention relates to temperature-corrected photoluminescence spectroscopy which may be applied to semiconductors and, in particular, photovoltaic films.01-19-2012
20120012757Non-Orthogonal Particle Detection Systems and Methods - Described herein is a particle detection system capable of spatially resolving the interaction of particles with a beam of electromagnetic radiation. Using a specific electromagnetic beam cross sectional shape and orientation, the detection sensitivity of a particle detection system can be improved. Also provided are methods for detecting and sizing particles in a manner that has low background signal and allows for spatially resolving the scattering or emission of electromagnetic radiation from particles.01-19-2012
20120104280METHOD OF FLUORESCENT MEASUREMENT OF SAMPLES, AND DEVICES THEREFROM - The invention provides a method and device for fluorescent measurement of a sample. The method includes impinging an incident beam having an excitation wavelength and a focus diameter on the sample to yield a laser spot that defines sample volume. The laser spot is displaced relative to sample volume in three dimensional space defined by sample volume. The laser spot is translated across the sample volume in depth direction to detect one or more emitted fluorescence signals from the sample volume. A depth profile and a thickness of the sample carrier obtained from the one or more emitted fluorescence signals, are used for measuring normalized bulk fluorescence. Further, at least one microvolume of interest is obtained from the depth profile, and the incident beam is focused on the microvolume of interest to obtain at least one concentrated emitted fluorescence signal.05-03-2012
20100019169REMOTE LASER INTERROGATION OF THREAT CLOUDS AND SURFACES - This invention concerns the remote detection of threat clouds and evaluation of their components. Also included is the remote detection and evaluation of contamination on surfaces or in air streams. To enable this detection, fluorophores that are attached to POSS are used with two-photon LIF imaging that provides enhanced background-free imaging even in the presence of scattering particles such as dust, sand and water droplets.01-28-2010
20110049389FLUORESCENT IMAGE OBTAINING DEVICE, FLUORESCENT IMAGE OBTAINING METHOD AND FLUORESCENT IMAGE OBTAINING PROGRAM - A fluorescent image obtaining device includes a light source that irradiates light such that a fluorescent material marked on a target in a biological sample lies in a non-excited state and a fluorescent material marked on a control with the target lies in an excited state, and an imaging unit that takes an image including the entire biological sample.03-03-2011
20120175528PARTICULATE COMPOSITIONS HAVING PLURAL RESPONSES TO EXCITATION RADIATION - A particulate composition comprises a plurality of particles wherein at least one of the particles comprises at least two different crystalline and/or glass phases, each phase comprising a host lattice and a dopant sensitive to electromagnetic radiation. The different phases simultaneously produce different responses on exposure to photons of the same energy, whereby the output from the particulate composition when exposed to said photons is the sum of the responses from the different phases.07-12-2012
20110006221METHOD FOR EVALUATING OIL-AND-FAT AMOUNT IN SEED AND METHOD FOR SCREENING FOR PLANT EXHIBITING VARIED LEVEL OF OIL-AND-FAT CONTENT - This invention is intended to evaluate the oil-and-fat amount in a seed and genetic changes thereof. A fusion protein of an oil body-specific protein, such as the oleosin-GFP fusion protein, and a fluorescent protein is expressed, and the oil-and-fat amount in a plant seed and changes thereof are evaluated based on the fluorescent intensity in a cotyledon of a fluorescent protein, such as GFP.01-13-2011
20100096561METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION - A radiation detection system (04-22-2010
20100096563LUMINESCENCE SENSOR - The present invention provides a luminescence sensor (04-22-2010
20100096562WIREGRID WAVEGUIDE - There is provided a wave guide comprising: a wave guiding medium, having an index of refraction and provided between first and second wave propagating planar structures at least said first planar structure comprises a plurality of slitted-apertures defining a length axis of the first reflective structure; the slitted apertures constructed and arranged to reflect a R-polarized component of said radiation oriented parallel to said length axis; and wherein said first planar structure is arranged between said wave guiding medium and an adjacent medium having an index of refraction equal or larger than the wave guiding medium. In one aspect of the invention, a waveguide is proposed to limit an excitation region wherein luminophores are excited; substantially independent from the surrounding media of the waveguide. Preferentially, the waveguide is used in a luminescence sensor.04-22-2010
20110089341Fluorometers - In apparatus for the production and detection of fluorescence at a sample surface, the height of the apparatus above the sample surface is reduced, and loss of the emitted fluorescence due to reflection loss and light scattering is minimized. The apparatus comprises a three-dimensionally curved light reflecting surface (04-21-2011
20120161035Method of classifying microorganisms using UV irradiation and excitation fluorescence - A method and device for detecting, differentiating from background and providing partial identification (i.e., classification) for biological particles found in aerosols or surface dust. The method is based on the phenomenon that luminescent excitation-emission (EEM) graphs of microorganisms obtained before and after perturbation by irradiation with ultraviolet light show characteristic patterns which differ according to the type of particle. For example, 06-28-2012
20100252749WIPER BLADE - The invention describes a wiper blade, in particular for windscreen wipers, which is at least partly provided with at least one coating, wherein the coating contains at least one indicator component for determining the layer thickness of the coating. The invention also describes a method for determining the layer thickness of a coasting of a wiper blade.10-07-2010
20100288943DEGRADABLE TAGGANT AND METHOD OF MAKING AND USING THEREOF - The present invention is a low-cost, easily deployed, degradable taggant that can be dispersed over a wide area to serve as a witness to activity in the area and for queuing of other sensors. The taggant enables nearly real-time change detection within the treated area using one or more simple optical sensing techniques.11-18-2010
20120126142FLUORESCENT ANALYSIS METHOD - Disclosed is a fluorescent analysis method whereby the throughput in DNA sequence analysis or the like can be improved. The method comprises irradiating a substrate, which carries biological molecules such as oligonucleotides immobilized thereon, with light for fluorescent measuring, collecting the generated fluorescence, dispersing the collected light, forming an image by focusing the light on a two-dimensional sensor, and then detecting the fluorescence with the two-dimensional sensor. In this method, since wavelengths are dispersed in different directions and then detected at the same time, the intensity of each dispersed wavelength and the position of the subject of spectroscopic imaging can be calculated even in the case where the wavelength dispersion distance is longer than the inter-lattice distance.05-24-2012
20120126143APPARATUS AND METHOD FOR OPERATING OPTICAL MICROCAVITY BY LIGHT EMITTING DIODE - An optical cavity mode apparatus comprising at least one microresonator; a light emitting diode for supplying light irradiation to the microresonator to stimulate the excitation level of the microresonator; and an optical detector to obtain spectra of the microresonator stimulated by the light emitting diode.05-24-2012
20120126141SURFACE COATING FOR INSPECTION - A method of inspecting an article, comprising applying an organic liquid substance over at least a portion of the article to be inspected so as to form a surface layer thereon, wherein said surface layer is luminescent. The article is irradiated with the surface layer thereon; and, scanning the article to determine its shape.05-24-2012
20100207036OPTICAL IMAGING DEVICE - The invention concerns an optical imaging device for a human or animal body, including: an optical sensing system, a drive system of at least one light collector from the optical sensing system, permitting modification of at least the position and/or direction, and a control system from the drive system, arranged so as to lead the light collector from the optical sensing system to at least one observation situation of at least one chosen region of the body to be examined, based on data concerning its topology.08-19-2010
20120168644CONFOCAL IMAGING METHODS AND APPARATUS - The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.07-05-2012
20120168643LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.07-05-2012
20110180727APPARATUS AND A METHOD OF DETERMINING THE PRESENCE OF AN ALUMINA LAYER ON A SURFACE OF A COMPONENT - Provided is a method for determining the presence of an alumina layer on a surface of a component. The method includes illuminating a surface of a component with radiation; detecting radiation emitted at a particular wavelength; analyzing the detected radiation; to determine the thickness of the alumina at at least one point on the surface of the component; and comparing the determined thickness of the alumina at the at least one point on the surface of the component with a predetermined thickness of alumina at that point to decide if the thickness of alumina at the at least one point on the surface of the component is satisfactory.07-28-2011
20110180726SYSTEM AND METHOD FOR DIGITAL PARALLEL FREQUENCY FLUOROMETRY - A system and method is provided for improved fluorescence decay time measurement. A digital heterodyning technique is disclosed in which a photon detector is sampled at a rate slightly faster than a digitally pulsed excitation signal. A resulting cross correlation frequency is low enough to be read by inexpensive electronics such as by a field programmable gate array. Phase information in the signal provides correlation with corresponding photon detections.07-28-2011
20100193703FRET DETECTION METHOD AND DEVICE - When FRET (Fluorescence Resonance Energy Transfer) detection of a large number of samples is performed in a short time for a sample consisting of a donor molecule and an acceptor molecule, the donor molecule is irradiated at first with first laser light used for exciting a donor molecule subjected to intensity modulation at a frequency of f+Δf, the accepter molecule is irradiated with second laser light used for exciting an acceptor molecule subjected to intensity modulation at a frequency of f, and fluorescence emitted from the accepter molecule is received. From a fluorescence signal thus received, a first signal component of fluorescence emitted from the accepter molecule through FRET, and a second signal component of fluorescence emitted from an accepter molecule excited through irradiation with the second laser light are extracted. Phase lags of the first and second signal components thus extracted are then calculated and the presence of generation of FRET is judged based on these phase lags.08-05-2010
20120313012Photobleaching and Intermittency Localization Microscopy - A method of image analysis creates super-resolution images from images with high densities of fluorophores by processing a movie in which the fluorescent molecules or particles are photobleaching or blinking. The method looks for the individual photobleaching events that can be located with high resolution (nm to tens of nanometers scale). The positions of the photobleaching or blinking events are then drawn in a composite image that is at a much higher resolution than the original fluorescence movie.12-13-2012
20120313011METHOD OF MEASURING LUMINESCENCE OF A MATERIAL - A method of measuring luminescence of a material is disclosed. The method includes applying a light source to excite an exposed material. The method also includes amplifying an emission signal of the material. The method further includes measuring a luminescent emission at a fixed time window of about 10 picoseconds to about 10 nanoseconds. The luminescence may be radio photoluminescence (RPL) or optically stimulated luminescence (OSL).12-13-2012
20120248337PHOSPHORESCENT ORGANIC COMPOUNDS - Compositions providing metal-independent phosphorescence due to a directed heavy atom effect are provided. Methods of providing a phosphorescent composition are also provided where a directed heavy atom effect is maintained to cause the composition to be phosphorescent. Manufacture of phosphorescent compositions using intermolecular and intramolecular directed heavy atom effects are disclosed.10-04-2012
20120248336Apparatus and Method for Batch Non-Contact Material Characterization - An apparatus for performing non-contact material characterization includes a wafer carrier adapted to hold a plurality of substrates and a material characterization device, such as a device for performing photoluminescence spectroscopy. The apparatus is adapted to perform non-contact material characterization on at least a portion of the wafer carrier, including the substrates disposed thereon.10-04-2012
20120248334Refractive Index Matching In Capillary Illumination - System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.10-04-2012
20120211671DEVICE AND METHOD FOR SPATIAL RECONSTRUCTING OF ABSORBERS MAPPING - The invention concerns a method for locating at least one absorber in a diffusing medium, using at least one excitation radiation and at least one detector (Φ08-23-2012
20120211670Systems and Methods of Detecting Force and Stress Using Tetrapod Nanocrystal - Systems and methods of detecting force on the nanoscale are provided. The described invention includes methods for detecting force using a tetrapod nanocrystal by exposing the tetrapod nanocrystal to light, which produces a luminescent response by the tetrapod nanocrystal. The method continues with detecting a difference in the luminescent response by the tetrapod nanocrystal relative to a base luminescent response that indicates a force between a first and second medium or stresses or strains experienced within a material. Such systems and methods find use with biological systems to measure forces in biological events or interactions.08-23-2012
20100051826Fluorescent Xanthenes and White Light Fluorophores - Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexing” techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges.03-04-2010
20090095919SYSTEM AND METHOD FOR MONITORING CELLULAR ACTIVITY - A system and method for monitoring cellular activity in a cellular specimen. According to one embodiment, a plurality of excitable markers are applied to the specimen. A multi-photon laser microscope is provided to excite a region of the specimen and cause fluorescence to be radiated from the region. The radiating fluorescence is processed by a spectral analyzer to separate the fluorescence into respective wavelength bands. The respective bands of fluorescence are then collected by an array of detectors, with each detector receiving a corresponding one of the wavelength bands.04-16-2009
20100032584TIIME GATED FLUORESCENT FLOW CYTOMETER - An apparatus (02-11-2010
20120313009Optical Detection System - An optical detection system includes a sample carrier receiving region that receives a sample carrier carrying a sample. The system further includes a source that emits an excitation signal having a wavelength within a predetermined wavelength range. The excitation signal illuminates the sample carrier. A first sub-portion of the excitation signal is absorbed by the sample, which emits characteristic radiation in response thereto. A second sub-portion of the excitation signal traverses the sample carrier. The system further includes a detector that detects the characteristic radiation. The system further includes an absorber that absorbs the excitation signal traversing the sample carrier without being absorbed by the sample or sample carrier. The absorber absorbs at least 95% of the excitation signal traversing the sample carrier.12-13-2012
20120313010System and Method for Automatically Determining Optimal Excitation and Emission Wavelengths of a Fluorophore - A system for performing spectrofluorometry of a fluorophore sample is provided. The system includes an input module that receives user input corresponding to spectrofluorometer settings. A control module transmits control signals for controlling the spectrofluorometer during respective wavelength scans of a fluorophore sample and a blank sample. The control signals provide for automatic execution of the wavelength scans over an excitation wavelength range and an emission wavelength range. A signal-to-background determination module automatically determines multiple signal-to-background ratios based on fluorescence measurements of the fluorophore sample and the blank sample received from the spectrofluorometer. A signal-to-background analysis module automatically determines the maximum signal-to-background ratio from the multiple signal-to-background ratios.12-13-2012
20080308746Optical Fluorescence Tomography - The invention relates to an optical fluorescence tomography system of biological targets. For increasing the resolution an the penetration depth of the impact radiation, in order to result a better depth signal, the biological target is supplied with a fluorescence dye (Material), bleachable by impact radiation, wherein a controllable dynamic tissue-wise bleaching-effect of the fluorescence dye is generated, so that by time dependant measuring of the maximum fluorescence response signal can be correlated to the actual selective bleaching front in depth.12-18-2008
20080272312Hyperspectral fluorescence and absorption bioimaging - A system and method of hyperspectral chemical imaging (fluorescence or absorption based) to provide an automated approach for a more detailed analysis of disease status of a biological sample. When a biological sample is labeled with a fluorescent or light-absorbing contrast-enhancing agent, interactions between the contrast-enhancing agent and one or more constituents (or cellular components) of the biological sample may be manifested through spectral contents of a plurality of regions in a hyperspectral chemical image of the sample. Observations of such manifestations through analysis of corresponding spectral contents may greatly assist a user (e.g., a pathologist) in detecting and differentiating diseased portions of the stained sample. Hyperspectral chemical imaging may allow to identify multiple cellular components within a biological sample and to image their distribution within the sample, thereby assisting a pathologist to successfully and more accurately identify diseased portion(s) of the sample for further diagnosis and treatment.11-06-2008
20100270479NON-IMAGING, WEAKLY FOCUSED FLUORESCENCE EMISSION APPARATUS AND METHOD - Apparatus and methods relating to non-imaging, multiphoton fluorescence and optical second harmonic generation (SHG) (and higher harmonic generation) emission and detection. A weakly focused excitation beam is used to generate fluorescence emission in a volume of between about 0.1 cm10-28-2010
20090065709Laser Scanner Device - Relates to a laser scanner device (03-12-2009
20120181451Waveguide-based Sensor - A sensor for sensing a target chemical with high signal-to-noise ratio is disclosed. In some embodiments, the sensor comprises a sensing region that is optically coupled with an attenuation region. The sensing region receives optical stimulation that comprises light characterized by an excitation wavelength. In response to exposure to the target chemical, the sensing region fluoresces at a fluorescence wavelength. The attenuation region receives light from the fluorescing sensing region that includes light characterized by the fluorescence wavelength (i.e., signal) and light characterized by the excitation wavelength (i.e., noise). The attenuation region conveys the light to a detector that provides an electrical output signal based on the target chemical. While conveying the light, however, the attenuation region improves the signal-to-noise ratio by attenuating light characterized by the excitation wavelength more than light characterized by the fluorescence region.07-19-2012
20100001209Halide-based scintillator nanomaterial - Scintillator material comprising nanoparticles (nanocrystals) comprising lead (Pb), iodine (I), and optionally one or both of oxygen (O) and hydrogen (H) wherein the nanoparticles exhibit room-temperature scintillation under gamma irradiation. The scintillator nanoparticles can comprise Pb01-07-2010
20130168574Silicophosphate phosphors - The invention relates to compounds of the general formula I07-04-2013
20120256102Dye-conjugated dendrimers - The invention provides dendrimers, conjugates thereof, and methods of using dendrimer conjugates. In one embodiment, the invention provides novel polymeric dendrimers as a new class of fluorescent labels. The labels can include multiple fluorescent dye molecules conjugated to a single polymeric backbone or core, such as a dendrimer. The dendrimers can have regular or irregular branched polymeric network structures that allow for the chemical attachment of multiple dye molecules, multiple color dyes, and/or multiple functional groups, in a combinatorial fashion. The fluorescent dendritic nanoprobes (FDNs) thus provide a new class of fluorescent reporters for fluorescence microscopy and imaging.10-11-2012
20120256101SUPER-RESOLUTION MICROSCOPY SYSTEM USING SPECKLE ILLUMINATION AND ARRAY SIGNAL PROCESSING - A nano-scale resolution fluorescence microscopy system and a method of obtaining an image using the nano-scale resolution microscopy system, and more particularly, a method and a microscopy system, capable of observing fluorescence probes in high resolution by radiating an irregular diffused light to have an incoherent speckle pattern that has low correlation in an adjacent space are disclosed. According to embodiments of the present invention, a diffraction limit of a fluorescence microscope may be overcome, and a super high resolution image on a nanometer scale may be obtained.10-11-2012
20090020710SEMICONDUCTOR NANOCRYSTALS FOR TIME DOMAIN OPTICAL IMAGING - A method of performing high repetition rate laser time domain imaging employs as fluoroprobes semiconductor nanocrystals having a fluorescence lifetime less than the laser pulse separation, typically less than 5 ns. The nanocrystals of the invention have a core/shell structure and may be surface treated to increase radiative decay. CdSe/Zns nanocrystals are particularly suitable.01-22-2009
20120228519System and Method for Fluorescence and Absorbance Analysis - A system or method for analyzing a sample include an input light source, a double subtractive monochromator positioned to receive light from the input light source and to sequentially illuminate the sample with each of a plurality of wavelengths, a multi-channel fluorescence detector positioned to receive and substantially simultaneously detect multiple wavelengths of light emitted by the sample for each of the plurality of excitation wavelengths, an absorption detector positioned to receive and detect light passing through the sample, and a computer in communication with the monochromator, the fluorescence detector, and the absorption detector, the computer controlling the monochromator to sequentially illuminate the sample with each of the plurality of wavelengths while measuring absorption and fluorescence of the sample based on signals received from the fluorescence and absorption detectors09-13-2012
20080302976Sensor with Improved Signal-to Noise Ratio and Improved Accuracy - The present invention provides a sensor and a method for detecting an optically variable molecule (12-11-2008
20110121203AUTHENTICATION APPARATUS FOR MOVING VALUE DOCUMENTS - An authentication apparatus used to authenticate a moving value document with uniform or non-uniform distribution of a pre-selected covert composition that includes an active ion that emits optical radiation at a pre-selected wavelength when excited by exciting incident light. The optical radiation is imaged onto at least one photodetector having first and second detector elements. The imaged intensities are captured at pre-determined times relating to the velocity of the value document. The ratio between the second detector element and the first detector element measured at the same image location or different image locations represents the characteristic decay time intensity data of the pre-selected wavelength emission. The authenticity of the value document is rejected when the pre-selected wavelength emission is not received by the at least one photodetector or when the output electronic signal ratio does not meet expected value.05-26-2011
20110121202Optical Fiber Imaging System And Method For Generating Fluorescence Imaging - A nonlinear fluorescence imaging system and method for generating fluorescence imaging includes a pulsed laser source for generating laser pulses at a first wavelength and an optical pulse stretcher including one or more optical pulse stretcher fibers having a first dispersion parameter at the first wavelength. The system also includes a probe for interfacing with a sample to deliver the laser pulses and extract fluorescence signals excited in the sample. One or more optical delivery fibers are included for delivering the laser pulses and collecting nonlinear fluorescence signals. The optical delivery fiber has a second dispersion parameter at the first wavelength which is opposite a polarity of the first dispersion parameter. A detector detects images based on the collected fluorescence signals.05-26-2011
20100327184FLUORESCENCE DETECTION DEVICE AND FLUORESCENCE DETECTION METHOD - A fluorescence detection device includes a flow cell body including a flow channel through which a measurement object flows, a laser light source unit that irradiates, with a laser beam, the measurement object passing through a measurement point in the flow channel, a light-receiving unit that receives fluorescence emitted from the measurement object irradiated with the laser beam and outputs a light-reception signal, and a processing unit that outputs an output value of fluorescence intensity based on the light-reception signal outputted by the light-receiving unit. The flow cell body has a lens provided on a surface thereof so as to traverse an optical path of the laser beam.12-30-2010
20090065710TRACE EVIDENCE DETECTION USING MULTIPLE LASER LIGHT SOURCES - A method for detecting trace evidence materials on a surface comprises irradiating the surface with radiation from two or more lasers emitting radiation at different wavelengths selected to stimulate luminescence in the trace materials. The evidence is detected by observing the surface through an optical filter arranged to transmit the luminescence, while blocking transmission of the laser radiation wavelengths reflected or scattered from the surface.03-12-2009
20080283773Particle or Cell Analyzer and Method - A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.11-20-2008
20110036995PATHOGEN DETECTION BY SIMULTANEOUS SIZE/FLUORESCENCE MEASUREMENT - A method and apparatus for detecting pathogens and particles in a fluid in which particle size and intrinsic fluorescence of a simple particle is determined, comprising a sample cell; a light source on one side of the sample cell for sending a focused beam of light through the sample, whereby portions of the beam of light are scattered at various angles by particles of various sizes present in the sample area; a particle size detector positioned in the light path for detecting a portion of forward scattered light; a pair of fluorescence detectors positioned off axis from the beam of light; and a pair of elliptical mirrors positioned such that an intersection of the incoming particle stream and the light beam are at one foci of each ellipsoid, and one of said pair of fluorescence detectors lies at the other foci.02-17-2011
20120298885FLUOROMETRIC ASSAY APPARATUS AND FLUOROMETRIC ASSAY METHOD - A fluorometric assay apparatus comprising an LED light source configured with at least two types of excitation LED that have different principle wavelengths from each other and are disposed in a two dimensional array on a substrate; an imaging lens for imaging a subject; a single excitation filter provided between the LED light source and a subject, the single excitation filter transmitting each of principle wavelength components of the LED light source; and a single detection long pass filter provided between the imaging lens and the subject.11-29-2012
20110210272Methods and Products for Analyzing Polymers - Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers.09-01-2011
20110226964PARTICLE OR CELL ANALYZER AND METHOD - A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.09-22-2011
20110226963METHOD AND APPARATUS FOR PERFORMING MULTIPOINT FCS - A method of performing fluorescence correlation spectroscopy with a fluorescence microscope includes selecting an illumination area of a sample, generating an illumination light beam and splitting the illumination light beam into at least three partial beams. The partial light beams are focused onto the selected illumination area using a microscope optical system of the fluorescence microscope so as to excite fluorescent dye particles in the illumination area to fluoresce. Fluorescent light emitted by the dye particles is detected and at least one diffusion coefficient representative of a diffusibility of the fluorescent dye particles is determined based on the detected fluorescent light.09-22-2011
20120080616DEVICE AND METHOD FOR MULTI-PHOTON FLUORESCENCE MICROSCOPY FOR OBTAINING INFORMATION FROM BIOLOGICAL TISSUE - A device for multi-photon fluorescence microscopy for obtaining information from biological tissue is provided. The device comprising a laser unit for generating an excitation radiation, an optical unit which is formed to focus the excitation radiation for generating an optical signal at different locations in or on an object to be examined, and a detector module for detecting the optical signal from the region of the object. The optical unit for generating the optical signal at different locations in or on the object is movable in at least one direction relative to the object.04-05-2012
20120080615PHOTOLYTICALLY AND ENVIRONMENTALLY STABLE MULTILAYER STRUCTURE FOR HIGH EFFICIENCY ELECTROMAGENTIC ENERGY CONVERSION AND SUSTAINED SECONDARY EMISSION - A multilayer structure for use in authentication that includes an energy conversion, at least one stability enhancement layer and at least one blocking layer is disclosed. Also disclosed are methods of creating and using the inventive multilayer structure for use in authentication.04-05-2012
20120080614PHOTOLYTICALLY AND ENVIRONMENTALLY STABLE MULTILAYER STRUCTURE FOR HIGH EFFICIENCY ELECTROMAGENTIC ENERGY CONVERSION AND SUSTAINED SECONDARY EMISSION - A multilayer structure for authentication that includes an energy conversion layer, at least one stability enhancement layer and at least one optical variable element is disclosed. Also disclosed are methods of creating and using the inventive multilayer structure for use-in authentication.04-05-2012
20100230614System And Method For Time-Division Multiplexed Optical Sensing Of Biosensors - A measurement system for use with fluorescent chemosensors has multiple stimulus light sources each coupled to at least one sensor. Multiple sensors each receiving light from a different light source connect to each of one or more photodetectors. A processing device drives the light sources in a time-division multiplexed manner, and reads the photodetector at an appropriate time for each sensor. The processing device calibrates the sensor readings and provides them in a way that is identified to the associated sensor.09-16-2010
20100230613MICROFLUIDIC DEVICES AND METHODS - Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.09-16-2010
20100230612Method of analysis of samples by determination of a function of specific brightness - A method for characterizing samples having units, by monitoring fluctuating intensities of radiation emitted, scattered and/or reflected by said units in at least one measurement volume, the monitoring being performed by at least one detection means, said method comprising the steps of: 09-16-2010
20100230611Lighting system, mehtod of lighting, optical detector, and method of optical detection - There is provided a lighting system having a high spatial resolution appropriate to a high-frequency component by evanescent waves in a negative refraction lens. The lighting system includes a light emitter thin film (09-16-2010
20120319007LUMINESCENCE MICROSCOPY - A luminescence microscopy method includes a sample being used, which comprises a certain substance, wherein the certain substance can be converted repeatedly from a first state, in which it can be excited into emitting luminescence radiation, into a second state, in which it cannot be excited into emitting luminescence radiation. The substance present in the sample can be brought into the first state by irradiating switch radiation. The certain substance can be excited into emitting luminescence radiation by irradiating excitation radiation. The sample emitting luminescence radiation can be displayed. A high-resolution selection of sample regions extending perpendicularly to a sample surface is carried out by irradiating either the switch radiation or the excitation radiation as structured illumination of the sample. A high-resolution selection of the sample surface is carried out by irradiating the switch radiation and/or the excitation radiation as TIRF illumination of the sample.12-20-2012
20120319009OPTICAL ANALYSIS DEVICE, OPTICAL ANALYSIS METHOD AND COMPUTER PROGRAM FOR OPTICAL ANALYSIS - The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region); generates time series light intensity data, computes a characteristic value of the light intensity indicating the presence or absence of the light from a single light-emitting particle in every time section of a predetermined width in the light intensity data; and detects the light-emitting particle crossing the inside of the micro region individually using the characteristic value, thereby enabling the counting of the light-emitting particle(s) or the acquisition of the information on the concentration or number density of the light-emitting particle.12-20-2012
20120280145OLIGOFLUORANTHENES AND METHODS AND APPARATUSES FOR DETECTING NITROAROMATICS USING THE SAME - The present application relates to compositions having at least one oligofluoranthene. The compositions may, for example, emit blue or green light when exposed to a blue or ultraviolet radiation. Methods of making the compositions are also disclosed, as well as methods and apparatuses for producing light and detecting nitroaromatics using the compositions.11-08-2012
20120280146METHOD AND SPECTROSCOPIC ANALYSIS APPLIANCE, ESPECIALLY FOR ANALYSING FOOD, WITH MULTI-CHANNEL TREATMENT OF SPECTRAL DATA - The invention relates to a method for the spectroscopic analysis of at least one sample, using a method for analysing spectroscopic data based on a multi-channel statistical model, said method comprising: the illumination of said or each sample to be analysed by a plurality of luminous excitation rays with respective wavelengths; the acquisition and the pre-treatment of frontal fluorescence spectra, each spectrum corresponding to a respective luminous excitation ray; for each sample, the calculation of a score vector by applying said multi-channel statistical model to the pre-treated spectra; and the determination of at least one parameter selected from a quality indicator of said or each sample and a parameter characterising a method that has been applied to said or each sample, from said score vector; the method being characterised in that the average spectral distance between the luminous excitation rays is at least 50 nm, over a spectral range of at least 100 nm. The invention also relates to an appliance for implementing such a method.11-08-2012
20120319008Signal Noise Reduction for Imaging in Biological Analysis - A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods of the present teachings and used for signal correction by systems of the present teachings.12-20-2012
20120326055SYSTEM AND METHOD FOR SUB-SURFACE FLUORESCENCE IMAGING - A system for sub-surface fluorescence imaging is provided, the system comprising: an excitation source for selectably emitting light at at least one of at least two excitation wavelengths or wavelength ranges at a target surface; and a light detector for detecting fluorescence emission wavelengths or wavelength ranges from the target surface; wherein at least one of the at least two excitation wavelengths or wavelength ranges causes fluorescing of at least one marker at a sub-surface depth, the emitted light at each of the at least two excitation wavelengths or wavelength ranges having different depths of optical penetration and causing fluorescing at respective different depths. A method for sub-surface fluorescence imaging is also provided, in some cases exemplified by a reconstruction of the sub-surface fluorescence topography.12-27-2012
20120326054In Situ Photoluminescence Characterization System and Method - A workpiece characterization system for measurement of photoluminescence and/or layer properties of a workpiece. The workpiece characterization system includes an excitation light impinging upon a surface of a workpiece whereby the workpiece emits photoluminescent light. The emitted photoluminescent light may be characterized and correlated for determination of workpiece parameters such as dopant concentrations and LED performance characteristics. Additionally, the workpiece characterization system may also include an illumination impinging upon a surface of said workpiece whereby the illumination source is encoded with layer information from said workpiece. One or both of the lights are selectively collected, and each collected light is angularly and spatially sampled. Layer properties and/or photoluminescence properties of said workpiece may be measured from the selectively collected, and angularly and spatially sampled lights.12-27-2012
20120091366SYSTEM AND METHOD FOR THE MEASUREMENT OF MULTIPLE FLUORESCENCE EMISSIONS IN A FLOW CYTOMETRY SYSTEM - A system and method for the measurement of multiple fluorescence emissions in a flow cytometry system is disclosed where each excitation light source is modulated with a different frequency. A single detector is used to collect the fluorescent emissions excited by all light sources, and the emissions are segregated using Fourier Transform techniques. Systems and methods for the correction of inter-beam coincidence are also disclosed.04-19-2012
20120326056GLASS SUBSTRATE LIGHT EMITTING ELEMENT AND METHODS FOR MANUFACTURING AND LUMINESCENCE THEREOF - A light emitting element (12-27-2012
20090272913FLUORESCENT ORGANIC NANOPARTICLES - A nanoparticle having a surfactant shell with a hydrophilic outer surface and a hydrophobic inner surface and an organic chromophore and a polymer having aromatic groups within the surfactant shell. A method of making nanoparticles by: emulsifying an aqueous composition of a surfactant and an organic solution of a monomer and an organic chromophore to form micelles of the monomer and the chromophore inside a surfactant shell; and polymerizing the monomer. A method of: reacting a ω-bromoalkyl acid with acryloyl acid lithium salt, and reacting the product with sodium hydride to produce an acryloyloxyalkyl carboxylic acid sodium salt. The compound shown below.11-05-2009
20130015367Wavefront Correction of Light Beam - An apparatus includes a transverse scanning optical system in the path of a first light beam traveling along a first optic axis; a wavefront correction system in the path of a second light beam traveling along a second optic axis, the wavefront correction system including a wavefront correction device having a spatial phase profile on its surface; a beam combiner that receives the first light beam and the second light beam and outputs an interference beam having a beat frequency equal to a difference frequency between the first light beam and second light beam; and a detection system placed relative to a random scattering medium, which is in the path of the interference beam. The detection system detects measurement light produced by the random scattering medium while the interference beam strikes the random scattering medium.01-17-2013
20130015370CONFOCAL FLUORESCENCE SLIDE SCANNER WITH PARALLEL DETECTION - An instrument and method for scanning a large specimen supported on a specimen holder has a plurality of illumination sources with each illumination, source being focused on a different focus spot of the specimen simultaneously. There are a plurality of spectrally resolved detectors to receive light reflected or emitted from the different focus spots simultaneously with each spectrally resolved detector receiving light from one illumination source only.01-17-2013
20130015369METHODS AND APPARATUS FOR AUTHENTICATING ARTICLES WITH LUMINESCENT PHOSPHOR COMPOUNDS - Methods and apparatus for article authentication include an exciting radiation generator that exposes an area of the article to exciting radiation, and at least two radiation detectors that detect emitted radiation from the area in a first band and in a second band that does not overlap the first band. The first band corresponds with a first emission sub-band of an emitting ion, and the second band corresponds with a second emission sub-band of the same emitting ion. A processing system calculates a comparison value that represents a mathematical relationship (e.g., a ratio) between a first intensity of the emitted radiation in the first band with a second intensity of the emitted radiation in the second band, and determines whether the comparison value compares favorably with an authentication parameter. When the comparison value compares favorably with the authentication parameter, the article is identified as being authentic.01-17-2013
20130015368INSPECTION APPARATUS AND INSPECTION METHODAANM NAKANISHI; HidetoshiAACI Kyoto-shiAACO JPAAGP NAKANISHI; Hidetoshi Kyoto-shi JPAANM TONOUCHI; MasayoshiAACI Suita-shiAACO JPAAGP TONOUCHI; Masayoshi Suita-shi JPAANM KAWAYAMA; IwaoAACI Suita-shiAACO JPAAGP KAWAYAMA; Iwao Suita-shi JP - A technology of inspecting a photoexcited carrier generation area of a photo device in a non-contact manner is provided. An inspection apparatus inspects a photovoltaic cell panel in which the photo device is formed. The inspection apparatus includes an irradiation part that irradiates the photovoltaic cell panel with pulsed light from a light receiving surface side and a detecting part (detector) that detects electric field intensity of a terahertz wave pulse, which is generated according to the irradiation of the pulsed light.01-17-2013
20110133100METHOD OF PUMPING QUANTUM DOTS - Strongly confined semiconductor quantum dots theoretically offer for broadband and continuous tunability of their emitting wavelength based upon simply varying the particle size. However, prior art consistently has demonstrated a lower particle size limit below which optical gain cannot be achieved, for example 2.3 nm for CdSe in toluene. As such the prior art points to combinations of alternative materials and host media as the route to achieving the goal of broadband emission sources using quantum dots. However, according to the invention optical gain can be achieved in quantum dots below these previous experimental limits by resonantly pumping the quantum dots to a specific excitonic state, i.e. electron position relative to the quantum dot, such that the multiexcitonic interferences are minimized. Using this approach optical gain in CdSe of R=2.1 nm and 1.5 nm has been demonstrated in the yellow/amber region of the visible spectrum.06-09-2011
20110140004GLASS ARTICLE WITH IDENTIFICATION MEANS AND METHOD FOR IDENTIFYING A GLASS ARTICLE - A glass article comprising identification means and a method for detecting the presence of the said identification means are disclosed. The glass article comprises at least one glass sheet which is covered by a layer comprising dispersed and invisible identification means. The identification means according to the invention allows identification of the presence of an intrinsic characteristic of said glass article which is invisible to the naked eye or difficult to detect.06-16-2011
20110147614REFRACTIVE INDEX MATCHED PHOSPHORS AND SUBSTRATES FOR SECURITY APPLICATIONS - Phosphor compositions are provided that can be incorporated into or onto plastic substrates as covert security features. The plastic substrates can be transparent and the phosphor compositions have a refractive index that effectively matches the refractive index of the plastic substrate to maintain the transparency. The phosphor compositions have absorption in the infrared, thus enabling excitation and detection of the compositions with an infrared emitting source.06-23-2011
20130020506Fluorescence Meter - A fluorescence meter for analyzing a sample, comprising a main beam path and at least one optical module. The fluorescence meter is embodied so as to provide at least one electromagnetic beam for exciting the sample and receive at least one electromagnetic beam emitted by the sample, at least some sections of at least two of the electromagnetic beams being located on one plane while extending along the main beam path.01-24-2013
20130020507Methods for Detecting Defects in Inorganic-Coated Polymer Surfaces - Lipophilic fluorescent substances can be used to detect surface defects in materials having hydrophilic (e.g., inorganic) coatings. Use of the described methods makes surface defects appear fluorescent, while the remaining surfaces are not labeled. The disclosed methods are inexpensive, rapid, and easy alternatives to existing approaches.01-24-2013
20130020505System And Method For Evaluating Material In Rotary Motion - Systems and methods evaluate material in rotary motion. Exposure duration is calculated based upon an intensity of radiation incident upon a sample area of the material and a desired radiation exposure for the material. Angular velocity for a rotational stage is calculated based upon the sample area, the calculated exposure duration, and an initial position of a linear stage. The initial position of the linear stage, the initial velocity of the linear stage, and the initial angular velocity of the rotational stage are set and a radiation generator is activated. The system then waits for time to read the next data sample based upon the calculated exposure duration and a fluorescence level of the material is determined. Angular velocity of the rotational stage and linear velocity of the linear stage are controlled based upon positional sensors to capture data from all areas of the material at the desired radiation exposure.01-24-2013
20130020504METHOD AND DEVICE FOR IDENTIFYING A PHOTOLUMINESCENT MATERIAL - A method for identifying a photoluminescent material that, after excitation with excitation light, emits emission light having different wavelengths is disclosed. The method includes irradiating the photoluminescent material with the excitation light, detecting a temporal intensity curve of at least two emission light components having different wavelengths, which components are emitted from the photoluminescent material as a result of the excitation, calculating initial intensities of the emission light components at a common time, determining at least one intensity parameter by correlating the calculated initial intensities, determining at least one decay parameter value for each of the emission light components from a time progression of their intensity and identifying the photoluminescent material using the intensity parameter(s) and the decay parameter values. A device configured to identify the photoluminescent material includes an excitation light source, a receiving apparatus, an evaluation apparatus and a control apparatus that performs the photoluminescent material identifying method.01-24-2013
20130020503METAL ENHANCED FLUORESCENCE FROM METALLIC NANOBURGER STRUCTURES - The present invention provides for metallic nanostructures or nanoburgers comprising a dielectric layer positioned between metallic layers and their use in metal enhanced emissions systems to enhance emissions from fluorophores, including intrinsic and extrinsic; luminophores; bioluminescent species and/or chemiluminescent species. The multilayer nanoburgers exhibit several distinctive properties including significantly enhanced intensity of emissions, decreased lifetime and increased photostability by simply varying the thickness of the dielectric layer while maintaining a constant thickness of the two metallic layers on opposite sides of the dielectric layer.01-24-2013
20120241647MULTIPHOTON LUMINESCENCE IMAGING OF PROTEIN CRYSTALS - A method for detecting protein crystals comprises: illuminating a sample with a laser to produce multiphoton excitation; collecting an emission spectrum; and determining whether the sample comprises protein crystals.09-27-2012
20080230718Feedback control system - An optical sensor feedback control device is provided comprising a luminescent sensing film, an optical processor adjacent the sensing film capable of sinusoidally photoexciting the luminescent sensing film and detecting the luminescent emission resulting therefrom, and a control means in communication with the optical processor for control of the magnitude of the photoexcitation, to receive information regarding the luminescent emission resulting therefrom, and generation of an electrical signal for determination of the magnitude and phase shift of the luminescence relative to the photoexcitation. The device of the present invention further has an optical processor positioning means in communication with the control means and the optical processor for adjusting the physical position of the optical processor and/or light source in relation to the sensing film based on data received from the control means. In addition, a method of feedback control of an optical sensor is provided.09-25-2008
20080230716DNA BIOSENSOR AND METHODS FOR MAKING AND USING THE SAME - Disclosed herein are biosensors and methods for making and using the same. In one embodiment, the sensor for detecting an analyte comprises: a substrate, recognition elements specific for the analyte, an excitation source, a detector, a chamber located between the substrate and the excitation source and between the substrate and the detector, and an emission filter. The recognition elements are tethered to the substrate such that the recognition elements can be exposed to a sample. The excitation source is capable of emitting a first light having a first light peak intensity at a first wavelength, wherein the first light can excite a luminophore to emit a second light when the recognition elements interact with the analyte. The detector is capable of detecting the second light emitted by the luminophore. The emission filter is capable of filtering in a band gap that includes the first light peak intensity.09-25-2008
20130168573MEASURING DEVICE, MEASURING SYSTEM, MEASURING METHOD, CONTROL PROGRAM, AND RECORDING MEDIUM - A measuring device (07-04-2013
20130168572STIMULATED EMISSION AND ENHANCED DETECTION OF CHEMICALS AND CHEMICAL COMPOUNDS - A method and apparatus for remotely detecting, locating, and identifying chemicals and chemical compounds through optically opaque materials. Electromagnetic radiation in the Terahertz range emitted from an antenna array is modulated to excite target molecules. The apparatus then stops the excitation energy and the molecules emit an electromagnetic signature detectable by the device at standoff distances.07-04-2013
20080224067Laser forensic detection method and apparatus - A method for detecting traces of material on a surface for forensic evidence gathering is disclosed. The surface is periodically illuminated with laser radiation. Pairs of images of the surface are recorded with one image in each pair recorded while the surface is illuminated and the other being recorded while the surface is not being illuminated. The images in each pair are subtracted and a video signal is generated from the subtracted images. The video signal can be displayed on a display device or recorded for later display and examination.09-18-2008
20130175456PHOTOLYTICALLY AND ENVIRONMENTALLY STABLE MULTILAYER STRUCTURE FOR HIGH EFFICIENCY ELECTROMAGNETIC ENERGY CONVERSION AND SUSTAINED SECONDARY EMISSION - Disclosed is a method for converting a primary electromagnetic radiation to a longer output wavelength that includes providing an energy conversion layer having a first photoluminescent material and a second photoluminescent material, exposing the energy conversion layer to the primary electromagnetic radiation, and transferring at least a portion of absorbed energy from the first photoluminescent material to the second photoluminescent material by dipolar coupling, such that the second photoluminescent material subsequently emits the longer output wavelength.07-11-2013
20130175457SURFACE PLASMON RESONANCE FLUORESCENCE ANALYSIS DEVICE AND SURFACE PLASMON RESONANCE FLUORESCENCE ANALYSIS METHOD - In the present invention, a specimen is made to flow on a metal film on a prism, and excitation light (α) is emitted in a predetermined direction. By changing the position of a reflective member that reflects the excitation light (α), and adjusting the orientation of a reflective surface of the reflective member, the incident angle (θ) is changed while maintaining a state in which the excitation light (α) that enters the prism is reflected at a specific position on the metal film. The intensity of light to be generated on the metal film is measured, and the reflective member is positioned to match the position of the reflective member and the orientation of the reflective surface when a maximum amount of light is measured.07-11-2013
20080217558Luminescence Sensor Comprising at Least Two Wire Grids - The present invention proposes a sub-wavelength luminescence sensor, such as e.g. a luminescence biosensor or a luminescence chemical sensor, comprising at least two wire grids (09-11-2008
20080217557Method and Apparatus For Analyzing a Dynamic Sample - A method of analysing a sample of biological material including components (09-11-2008
20120248335METHOD AND APPARATUS FOR INSPECTING SOLAR CELL - Disclosed herein are a method and an apparatus for inspecting solar cells. According to an exemplary embodiment of the present invention, a method for inspecting solar cells includes: (a) preparing solar cells; (b) obtaining a photoluminescence image(s) by irradiating light to the prepared solar cells; and (c) determining a conversion efficiency rating of each solar cell according to brightness of the obtained image. Further, an apparatus for inspecting solar cells includes a stage unit that transfers solar cells; a light source unit that irradiates light to a surface of the solar cell transferred through the stage unit; a camera unit that obtains a photoluminescence image according to the light irradiated from the light source unit; and an efficiency determination unit that determines a conversion efficiency rating of each solar cell based on brightness of an image obtained from the camera unit according to preset programs.10-04-2012
20130126759OPTICAL MICROSCOPY WITH PHOTOTRANSFORMABLE OPTICAL LABELS - An apparatus includes a position-sensitive detector to detect intensities of radiation as a function of position on the detector, and an optical system, characterized by a diffraction-limited resolution volume, adapted for imaging light emitted from activated and excited phototransformable optical labels (“PTOLs”) in a sample onto the position sensitive-detector. A first light source provides activation radiation to the sample to activate a subset of the PTOLs that are distributed in the sample with a density greater than an inverse of the diffraction-limited resolution volume of the optical system. A second light source provides excitation radiation to the sample to excite a portion of the PTOLs in the subset of the PTOLs. A controller controls one both of the activation radiation and the excitation radiation provided to the sample such that a density of PTOLs in the portion of the PTOLs is less than the inverse of the diffraction-limited resolution volume.05-23-2013
20130099135LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.04-25-2013
20130112895Method for Characterising an Agri-Food Product and Device for Implementing Such a Method - The invention relates to a method for characterising one or more samples of an agri-food product, in particular intended for determining the naturality, freshness and authenticity of such a product and/or the conformity of same with a target product. The method of the invention is characterised in that it comprises: acquiring a plurality of natural fluorescence spectra of the sample; applying a multivariate or multi-path analysis method to said spectra, wherein said method provides a limited number F of variables representing said or each sample, in order to enable the representation thereof by a point (PE) in a space having F dimensions; calculating a distance (D) between said point representing said or each sample and a target (C05-09-2013
20110266462FLUORESCENCE DETECTING DEVICE AND FLUORESCENCE DETECTING METHOD - When a fluorescence relaxation time of a fluorochrome is determined using a measurement object obtained by attaching the fluorochrome to an analyte, a first laser beam is intensity-modulated by a modulation signal with a frequency of f11-03-2011
20130126756FLUORESCENCE IMAGING APPARATUS AND METHOD - A fluorescence emission imaging method and apparatus allows for high frame rate imaging in scattering medium as well as for fluorescence, phosphorescence, or luminescence lifetime imaging, time-resolved fluorescence, phosphorescence, or luminescence lifetime spectroscopy and imaging. A method involves providing an illumination beam, propagating the illumination beam to a light modulator array, modulating the illumination beam so as to generate an array of point sources, wherein each of the point sources is modulated at a frequency, imaging the modulated illumination beam on the object, and detecting a fluorescent, phosphorescent, or luminescent emission from the object. An optical imaging component in the form of a modulation mask has multiple bands. Each band has alternating transmissive and/or reflective and/or absorptive regions that are patterned such that light scanned over a band will be modulated at a band-related frequency.05-23-2013
20130126758METHODS AND SYSTEMS FOR IMAGE DATA PROCESSING - Embodiments of the computer-implemented methods, storage mediums, and systems may be configured to determine locations of particles within a first image of the particles. The particles may have fluorescence-material associated therewith. The embodiments may include calculating a transform parameter, and the transform parameter may define an estimated movement in the locations of the particles between the first image of the particles and a second image of the particles. The embodiments may further including applying the transform parameter to the locations of the particles within the first image to determine movement locations of the particles within the second image.05-23-2013
20130126755Method and device for simultaneous multi-channel and multi-method acquisition of synchronized parameters in cross-system fluorescence lifetime applications - A device for simultaneous multi-channel, multi-method acquisition of synchronized parameters in fluorescence lifetime applications is provided with a fluorescence macroscope, microscope or nanoscope, a pulsed laser source, a beam splitter, a TSCSPC detector, and a synchronized peripheral device. A sample is irradiated with a pulsed, high frequency, polarized or unpolarized ps or ns laser beam. The fluorescence radiation from the sample is guided onto a beam splitter to generate two partial beams that are deflected onto a list-mode detector operating by space- and time-correlated single photon counting. All physical parameters of each photon are acquiring by the list-mode detector simultaneously and saved in control electronics. Simultaneously, further parameters are acquired in synchronization by a peripheral device and saved. The saved parameters of the list-mode detector and of the peripheral device are combined to a multi-parameter, multi-method acquisition system in a 05-23-2013
20130181143MICROSCOPY WITH ADAPTIVE OPTICS - A method of manipulating a focused light beam includes focusing a beam of excitation light with a lens to a focal spot within a sample, where a cross-section of the beam includes individual beamlets. Directions and/or relative phases of the individual beamlets of the excitation beam at a rear pupil of the lens are individually varied with a wavefront modulating element, and emission light emitted from the focal spot is detected while the directions or relative phases of individual beamlets are varied. The directions of individual beamlets are controlled to either maximize or minimize the emission light from the focal spot, and the relative phases of individual beamlets are controlled to increase the emission light from the focal spot.07-18-2013
20130181144ARTICLES INCORPORATING THERMOGRAPHIC PHOSPHORS, AND METHODS AND APPARATUS FOR AUTHENTICATING SUCH ARTICLES - Embodiments include methods and apparatus for identifying a thermographic phosphor (e.g., Er:YIG) incorporated on or within an article. The method and apparatus embodiments include an excitation energy generator selectively exposing the article to excitation energy in an absorption band of the thermographic phosphor. An emitted radiation detector detects first emission characteristics of first emitted radiation from the article within an emission band of the thermographic phosphor when the article has a first temperature, and detects second emission characteristics of second emitted radiation from the article within the emission band when the article has a second temperature that is different from the first temperature. A temperature adjustment element is configured to adjust the temperature of the article. Embodiments further include a processing system determining whether the first emission characteristics are sufficiently different from the second emission characteristics.07-18-2013
20090294692PLASMONIC ASSISTED SYSTEMS AND METHODS FOR INTERIOR ENERGY-ACTIVATION FROM AN EXTERIOR SOURCE - A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.12-03-2009
20130146787METHOD FOR DETERMINING MATERIAL PARAMETERS OF A DOPED SEMICONDUCTOR SUBSTRATE BY MEASURING PHOTOLUMINESCENT RADIATION - Method for determining material parameters of a doped semiconductor substrate, including: applying electromagnetic excitation radiation in order to produce luminescent radiation in the semiconductor substrate, the temporal profile of the excitation radiation intensity is periodically modulated, so that the rate of generation of charge carrier pairs in the substrate has a maximum and minimum during an excitation period, and at least the relative temporal profile of the rate of generation G(t) is determined by time-dependent measurement of the excitation radiation intensity, time-resolved measuring luminescent radiation intensity emanating from a measuring region, at least the relative temporal profile of the intensity of the luminescent radiation Φ(t) is measured during an excitation period, determining a material parameter of the semiconductor substrate based on G(t) and Φ(t). The effective lifetime of the substrate is determined from the time difference between the maximum of G(t) and a corresponding maximum of Φ(t).06-13-2013
20110226962METHOD AND APPARATUS FOR DETECTING FLUORESCENCE EMITTED BY PARTICLE-BOUND FLUOROPHORES CONFINED BY PARTICLE TRAPS - A method of detecting a fluorescence signal emitted by fluorophores bound to particles confined in a particle trap, includes an objective lens having a focal plane, which is normally the focal plane for incident collimated light. The particle trap is typically located in the focal plane, and a beam of excitation light is directed via the objective lens onto the confined particles in the trap. The excitation light is in the form of a divergent beam coming to focus at a plane displaced from the focal plane. The divergent beam has a spot diameter at the focal plane determined by the divergence of the beam. The fluorescent light emitted by the fluorophores is detected with a confocal detector.09-22-2011
20080283772Methods and systems for analyzing fluorescent materials with reduced authofluorescence - Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions11-20-2008
20090084981High-resolution tracking of industrial process materials using trace incorporation of luminescent markers - A method of marking an industrial process material including selectively incorporating a luminescent marker onto and/or into the industrial process material in a trace amount insufficient to be optically detectable in the presence of ambient light but sufficient to be non-destructively optically detectable in and/or on the industrial proce material in situ in the field or on-site. The trace amount of the luminescent marker is used to track, identify authenticate the industrial process material for at least one of material control, inventory control, stock control, logistics control, quality control and pollution control.04-02-2009
20120273696Compositions Having Multiple Responses to Excitation Radiation and Methods for Making Same - The present invention relates to a composition having a first response to a first electromagnetic radiation and, after intermediate exposure to a second electromagnetic radiation, a second response to the first electromagnetic radiation, different from the first response. In one aspect, the composition exhibits a regenerated first response to the first electromagnetic radiation after exposure to a third electromagnetic radiation.11-01-2012
20120273695HIGH RESOLUTION FLUORESCENCE DETECTION SYSTEM - A compact image sensor for imaging radiation emitted by fluorescing objects exposed to excitation light is disclosed. The compact image sensor includes a light guide defining a longitudinal axis for channeling radiation emitted by the fluorescing object; a reflective surface defined on the light guide that is oriented at an angle with respect to the longitudinal axis of the light guide to reflect the excitation light away from a detector of the image sensor; and the detector positioned at an end of the light guide for imaging radiation emitted by the fluorescing object. Also disclosed is a fluorescence imaging system for imaging radiation emitted by a fluorescing object to be imaged by compact image sensor and a method of fluorescence imaging.11-01-2012
20110233427MAGNETITE-SILVER HETERODIMER NANOPARTICLES AND THEIR PREPARATION AND USE FOR TWO-PHOTON FLUORESCENCE - A heterodimer particle is provided which comprises a first component particle comprising magnetite and a second component particle comprising silver. The second component particle may have a structure and a particle size selected to generate two-photon fluorescence emission. The heterodimer particle may be irradiated with light of a wavelength selected to induce two-photon fluorescence emission, which is then detected. Tetramethylammonium hydroxide may be bonded to the surface of the first component and glutathione may be bonded to the surface of the second component. The heterodimer particle may be formed by preparing a magnetite particle and growing a silver particle on the magnetite particle, in the presence of 1,2-dodecanediol as a reducing agent.09-29-2011
20100314557FLUORESCENCE DETECTION DEVICE AND FLUORESCENCE DETECTION METHOD - In a fluorescence detection device and a fluorescence detection method, forward-scattered light which is scattered from a measurement object irradiated with a laser beam is received and detection signals for informing the measurement object passing through the measurement point and for identifying a focus position of the forward-scattered light are produced. While, fluorescence emitted by the measurement object is received through a collecting lens and a light-reception signal of the fluorescence is outputted. The fluorescence intensity level is outputted based on the outputted light-reception signal and the produced detection signals. A focus position of the forward-scattered light is identified from the produced detection signals and the light reception-signal is corrected using a correction coefficient corresponding to the identified focus position.12-16-2010
201003145561,8-NAPHTHALIMIDE DERIVATIVES AS SCINTILLATION AGENTS, IN PARTICULAR FOR DISCRIMINATING BETWEEN FAST NEUTRONS AND GAMMA RAYS - The invention relates to the use of 1,8-naphthalimide derivatives and of their salts as scintillation agents and more specifically as agents for discriminating between fast neutrons and gamma rays.12-16-2010
20110272597METHOD FOR GENERATING OPTICAL TOMOGRAPHIC INFORMATION, OPTICAL TOMOGRAPHIC INFORMATION GENERATING APPARATUS, AND STORAGE MEDIUM - Measurement data of intensities of fluorescence obtained by directing excitation light onto a subject is acquired. An initial value of an absorption coefficient of the phosphor is set on the basis of a concentration distribution of the phosphor, an intensity distribution of the fluorescence on the basis of an absorption coefficient and a diffusion coefficient (reduced scattering coefficient) of the subject, which are set beforehand, are calculated, and the measurement data is compared with the calculation result. If these are found not to be matched, an absorption coefficient of the phosphor at which the error will be a minimum is estimated by performing an inverse problem calculation using a mathematical model. The calculation of the intensity distribution of the fluorescence and evaluation of the error from the obtained concentration distribution are repeated using the absorption coefficient, and a concentration distribution for which the error is the minimum is acquired.11-10-2011
20130153788NON-CONTACT TOTAL EMISSION DETECTION METHOD AND SYSTEM FOR MULTI-PHOTON MICROSCOPY - A multi-photon microscope having an illumination source that transmits an illumination light into a housing having an objective lens arrangement for illuminating a sample disposed outside the housing and directing a first portion of emission light emitted from the sample to a detection system is disclosed. A light collection system is disposed proximate the objective lens arrangement for directing a second portion of emission light in a coaxial relationship with the first portion of emission light to the detection system such that substantially all of the emission light on, around and above the illumination region is detected.06-20-2013
20130153789LUMINESCENT MATERIALS, ARTICLES INCORPORATING LUMINESCENT MATERIALS, AND METHODS FOR PERFORMING ARTICLE AUTHENTICATION - Embodiments of luminescent materials and articles include first and second particles of first and second inorganic host lattices. The first particles are capable of producing first emissions having one or more first emission peaks at one or more first wavelengths. The first emissions have a first decay half-life that is long enough for the first emissions to be perceptible to the human eye for a first time period that begins when appropriate excitation of the luminescent material is discontinued. The second particles are capable of producing second emissions having one or more second emission peaks at one or more second wavelengths. The second emissions have a second decay half-life that is longer than the first decay half-life by a decay time difference that is sufficient for the second emissions to be perceptible to the human eye for a second time period that begins after the first time period.06-20-2013
20130126754METHOD FOR MEASURING BIOLOGICAL CONTAMINATION OF SEA WATER DESALINATION FACILITY AND SYSTEM THEREOF - The present invention relates to a method for measuring degree of biological contamination in a sea water desalination facility, and is characterized by comprising the following steps of: a) collecting any one selected from a group consisting of raw sea water flowing into the sea water desalination facility, pre-treated water prepared by pre-treating the raw sea water, product water (permeate) produced after the pre-treated water goes through a desalination process and brine; and b) measuring wavelength and strength of a natural phosphor, which is contained in the raw sea water, pre-treated water, product water (permeate) or brine, using a fluorescence spectrophotometer.05-23-2013
20130119274LUMINESCENT BORATES, MATERIALS AND ARTICLES INCORPORATING SUCH BORATES, AND METHODS AND APPARATUS FOR THEIR PRODUCTION AND USE IN ARTICLE AUTHENTICATION - Embodiments include luminescent materials and associated production methods. The material includes a crystal borate having a first substitutable element, neodymium substituted for the first substitutable element at a first substitution percentage of at least about 20 percent, and ytterbium substituted for the first substitutable element at a second substitution percentage. The material also may include chromium substituted for a second substitutable element. The material also may include a medium within which particles of the borate are incorporated. The medium, with the luminescent material particles, may form a security feature of an article. Embodiments of methods for identifying whether such a luminescent material is incorporated with an article include exposing a portion of the article to excitation in a chromium absorption band, and determining whether a detected emission produced by the article as a result of the excitation indicates an ytterbium emission after termination of the exposing step.05-16-2013
20110303856DETECTION METHOD BASED ON WHISPERING GALLERY MODES IN MICROSPHERES FLOATING IN A SOLUTION UNDER TEST - The detection method can include: exciting at least one fluorescent microsphere floating in said solution under test by exposing it to excitation light; measuring a fluorescence spectrum of said at least one fluorescent microsphere, said fluorescence spectrum comprising multiple whispering gallery modes; obtaining a set of predetermined fluorescence spectra corresponding to those of microspheres having varying external refractive index and varying radius, identifying a matching fluorescence spectrum of the set which more closely matches the measured fluorescence spectrum; comparing the matching fluorescence spectrum of the set to the measured fluorescence spectrum.12-15-2011
20110309266FLUORESCENCE DETECTION METHOD, FLUORESCENCE DETECTING DEVICE AND PROGRAM - Disclosed herein is a fluorescence detection method. The fluorescence detection method includes the steps of: irradiating a measurement object with laser light modulated at a predetermined frequency; receiving fluorescence emitted by the measurement object and outputting two or more pulsed fluorescent signals; setting reference timing in units of period corresponding to the frequency; acquiring a generation time to output of each of the pulsed fluorescent signals based on the reference timing; generating a cumulative fluorescent signal indicating the relationship between a generation frequency of the pulsed fluorescent signal and the generation time; determining, by using a signal corresponding to modulation of the laser light as a reference signal, a phase difference between the reference signal and the cumulative fluorescent signal; and determining, by using the phase difference, a fluorescence relaxation time of the fluorescence emitted by the measurement object.12-22-2011
20110309265DIAMOND NANOWIRES - In a general aspect, a system includes a plurality of diamond nanowires disposed on the surface of a diamond substrate, at least some of the nanowires including a color center. The system also includes a light source configured to illuminate at least one of the plurality of nanowires with excitation light at a wavelength corresponding to an excitation wavelength of the color center included in the illuminated nanowire; and an optical receiver configured to receive a fluorescence emitted from the color center included in the illuminated nanowire in response to the excitation light.12-22-2011
20130187061METHOD FOR NONDESTRUCTIVE TESTING OF WORKPIECE SURFACES - A method for nondestructive testing of workpiece surfaces by a fluorescent penetration test is disclosed. An embodiment of the method includes a) cleaning the area of the workpiece surface that is to be inspected; b) applying a fluorescent liquid penetrant to the area of the workpiece surface that is to be inspected, where the penetrant penetrates into possible recesses in the workpiece surface; c) removing the excess penetrant from the workpiece surface; d) applying a developer to the area of the workpiece surface that is to be inspected; e) bleaching the fluorescent penetrant by a beam of light in the layer formed by applying the developer to the workpiece surface; and 0 visual evaluation of the fluorescent penetrant remaining in the recesses present in the workpiece surface.07-25-2013
20110315896LUMINESCENT GLASS ELEMENT, PRODUCING METHOD THEREOF AND LUMINESCING METHOD THEREOF - The present invention relates to a luminescent glass element comprising a luminescent glass substrate, which a metal layer is positioned on a surface thereof. The metal layer is provided with a metal microstructure. The luminescent glass substrate has composite oxides represented as the following formula: aM12-29-2011
20110315894Apparatus For and Method of Measuring Bio-Chips Using Uniform Total Internal Reflection Illumination - Disclosed herein is an apparatus for and method of measuring bio-chips, which can implement an illumination method of a novel type that illuminates a bio sample (which may be also referred to as a “bio specimen”) through a side face of a substrate using a diffusion plate to form an evanescent field by the illumination light over the entire surface of a substrate so as to uniformly secure brightness of the illuminated light over a wide area of a substrate, thereby more efficiently measuring fluorescence information of a bio-chip over a wide field of view.12-29-2011
20120001091LUMINESCENT GLASS ELEMENT, PRODUCING METHOD THEREOF AND LUMINESCING METHOD THEREOF - The present invention relates to a luminescent glass element comprising a luminescent glass substrate, which a metal layer is positioned on a surface thereof. The metal layer is provided with a metal microstructure. The luminescent glass substrate has composite oxides represented as the following formula: aM01-05-2012
20130193347METHOD AND DEVICE FOR DETERMINING CONTENT OF THE MIDDLE AND PROTEIN BOUND UREMIC TOXINS IN A BIOLOGICAL FLUID - This invention relates to a novel method and a device for determining middle and protein bound uremic toxins in the biological fluids. More specifically, the present invention relates to an optical method utilizing fluorescence, preferable fluorescence of the spent dialysate, and a specific model, including a unique set of optical spectral components at certain wavelengths, to determine, preferable on-line, the concentration of the middle and protein bound uremic toxins such as beta2-microglobulin (B2M), and indoxyl sulfate (IS).08-01-2013
20120018651NANOSCALE IMAGING OF MOLECULAR POSITIONS AND ANISOTROPIES - A Polarization Fluorescence Photoactivation Localization Microscopy (P-FPALM) system and method are provided to simultaneously image the localizations and fluorescence anisotropics of large numbers of single molecules within a sample. The system modifies known FPALM systems by adding a polarizing beam splitter. The beam splitter polarizes emissions perpendicular and parallel to an axis in the sample to allow spatially separate imaging of fluorescence emitted from a sample. The system includes lenses and mirrors so that the separate, polarized beams are detected simultaneously. The present invention includes methods of using the system to image localizations and fluorescence anisotropics of single molecules, and methods of using data obtained with the system to predict 3-D orientation of the molecules. The system and method achieve substantially improved lateral resolution within even dense samples over known microscopic imaging techniques, and does not compromise speed or sensitivity.01-26-2012
20130193346Method for Identifying an Object - The invention relates to a method for identifying an object, wherein said object has a security element, which contains one or more inorganic luminescent pigments, wherein the method comprises the steps of producing an emission spectrum of the luminescent pigment and comparing the obtained emission spectrum with the spectrum specified for the security element. The invention further relates to a security element, by means of which it is possible to determine the authenticity of a product in a simple manner.08-01-2013
20120025100PHOTOLUMINESCENCE MEASUREMENT - A photoluminescence measurement system can include an optical source.02-02-2012
20120025098FLUORESCENCE DETECTION DEVICE AND FLUORESCENCE DETECTION METHOD - When receiving fluorescence emitted by a measurement object irradiated with laser light emitted from a laser light source unit, a fluorescence detection device generates a modulation signal for modulating the intensity of the laser light and modulates the laser light using the modulation signal. The fluorescence detection device obtains a fluorescent signal of the fluorescence emitted by the measurement object irradiated with the laser light, and calculates, from the fluorescent signal, a fluorescence intensity and the phase delay of the fluorescence with respect to the modulation signal. At the time, the fluorescence detection device controls the operation amounts of the signal level of a DC component of the modulation signal and the gain of amplification just after the output of the fluorescent signal so that the value of a fluorescence intensity signal falls within a preset range. After the operation amounts are settled, the fluorescence detection device calculates the fluorescence intensity and then calculates the fluorescence relaxation time of the fluorescence emitted by the measurement object using the phase delay.02-02-2012
20130200276SUBSTANCE DETECTION, INSPECTION AND CLASSIFICATION SYSTEM USING ENHANCED PHOTOEMISSION SPECTROSCOPY - A handheld or portable detection system with a high degree of specificity and accuracy, capable of use at small and substantial standoff distances (e.g., greater than 12 inches) is utilized to identify specific substances and mixtures thereof in order to provide information to officials for identification purposes and assists in determinations related to the legality, hazardous nature and/or disposition decision of such substance(s). The system uses a synchronous detector and visible light filter to enhance detection capabilities.08-08-2013
20130099136FLUORESCENT NANOSCOPY DEVICE AND METHOD - A method for analysis of an object dyed with fluorescent coloring agents. Separately fluorescing visible molecules or nanoparticles are periodically formed in different object parts, the laser produces the oscillation thereof which is sufficient for recording the non-overlapping images of the molecules or nanoparticles and for decoloring already recorded fluorescent molecules, wherein tens of thousands of pictures of recorded individual molecule or nanoparticle images, in the form of stains having a diameter on the order of a fluorescent light wavelength multiplied by a microscope amplification, are processed by a computer for searching the coordinates of the stain centers and building the object image according to millions of calculated stain center co-ordinates corresponding to the co-ordinates of the individual fluorescent molecules or nanoparticles. Two-dimensional and three-dimensional images are provided for proteins, nucleic acids and lipids with different coloring agents.04-25-2013
20120080613Photolytically and Environmentally Stable Multilayer Structure for High Efficiency Electromagnetic Energy Conversion and Sustained Secondary Emission - A multilayer structure for sustained conversion of a primary electromagnetic radiation into another electromagnetic radiation characterized by a spectrum of a higher average wavelength is disclosed. Also disclosed are methods of creating and using the inventive multilayer structure.04-05-2012
20120085933FLUORESCENCE DETECTION DEVICE AND FLUORESCENCE DETECTION METHOD - A fluorescence emitted by a measurement object at a measurement point is measured. When the fluorescence is measured, a measurement object is irradiated with laser light whose intensity is time-modulated by using a modulation signal at a predetermined frequency. Then, the fluorescence emitted by the measurement object is formed to a flux of the fluorescence having uniform distribution of light intensity, and a plurality of partial fluorescent signals are generated by receiving a plurality of divided portions of the flux of the fluorescence. At least some of the partial fluorescent signals are added altogether to generate a single fluorescent signal. Finally, a fluorescence relaxation time of the fluorescence emitted by the measurement object is calculated from the generated fluorescent signal by using the modulation signal. When fluorescence intensity of the fluorescence calculated from the fluorescent signal exceeds a predetermined threshold, the partial fluorescent signals to be added are limited in number. Thereby, an output power of the light-receiving unit can not be prevented from saturation.04-12-2012
20120085932SYSTEMS AND METHODS FOR MULTISPECTRAL IMAGING04-12-2012
20120085931FLUORESCING GEL FORMULATIONS AND THEIR APPLICATIONS - Fluorescing gel formulations are disclosed for monitoring cleaning of a surface. The fluorescing gel formulations are stable, fluoresce under UV light, and do not leave a mark after drying and removal. The compositions include an oppositely charged complexing agent which is used in combination with an anionic or cationic optical brightener. In some embodiments, the compositions include a cationic optical brightener with no complexing agent.04-12-2012
20120085930DETECTION METHOD - The present invention relates to a method for detecting the presence of a fungicide on a seed. In particular, the method according to the invention may be used to ensure that sufficient quantities of the fungicide or insecticide are present on the seed. In a particular embodiment the fungicide detected is thiabendazole.04-12-2012

Patent applications in class Methods