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250 - Radiant energy

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Class / Patent application numberDescriptionNumber of patent applications / Date published
250459100 Methods 419
250461100 With ultraviolet source 45
250462100 Self-luminous article 4
20080277596Impact Indicating Microcapsules - The present disclosure is directed at an impact indictor that may be coated on a structure to detect impacts thereon. The indicator may be provided within microcapsules. Upon rupture of the microcapsules, the indicator may be exposed to a pH activator, wherein the indicator may then exhibit fluorescence upon exposure to electromagnetic energy.11-13-2008
20120126144LIGHT EMITTING DEVICE PACKAGE AND METHOD OF FABRICATING THE SAME - Provided are a light emitting device package and a method of fabricating the light emitting device package. The light emitting device packages includes a body, a light emitting device disposed in the body, and a wavelength converting partwavelength converting part disposed on the light emitting device to convert a wavelength of light emitted from the light emitting device. The wavelength converting partwavelength converting part has a thickness decreasing in a direction away from a center of the light emitting device.05-24-2012
20100327185SMALL BEZEL DISPLAY SCREEN HAVING A SUPPORTING FILM LAYER - Embodiments of the present invention generally provide an apparatus and method for forming a display screen assembly that comprises multiple panel assemblies which are positioned to form a tiled display device that has improved visual characteristics, is easy to assemble and has a reduced manufacturing cost. In general, each panel assembly is formed so that when it is positioned in a display screen assembly the grid pattern, formed by the gap between the illuminated regions in adjacent panel assemblies, can be minimized. In one embodiment, the unwanted visual effect of the grid pattern is mitigated by minimizing and controlling the space, or gaps, formed between the illuminated area in adjacent panel assemblies. Embodiments of the present invention may also provide an apparatus and method for forming a single panel assembly that is used to display an image.12-30-2010
20100314558LUMINESCENT SYSTEM - A luminescent system includes a layer of donor material, an acceptor material and a barrier layer therebetween. The energy transfer between the donor and acceptor is biased to the acceptor layer, by an asymmetric energy transfer efficiency created by the barrier layer. Energy from the donor material is converted into photo-luminescence in the acceptor layer by discouraging photo-luminescence quenching caused by energy backflow.12-16-2010
20120161034SENSOR SYSTEM FOR FLUID DETECTION AND DISCRIMINATION - A light transmitting optical fiber shines light at a side edge portion of a hemispherical lens. The light is transmitted along the periphery of the lens to a second side edge portion located opposite the first side edge portion. A light sensitive component detects light at the second edge portion which light resulted from the light transmitted at the first side edge portion. The intensity of light detected at the second side edge portion is indicative of the fluid to which the lens is exposed, and can be evaluated and signaled by a microprocessor.06-28-2012
20090194706Method and device for the selective withdrawal of compontents from complex mixtures - The method according to the invention permits a selected withdrawal of one or a few molecularly disperse or cellular components of a system, such as molecules, molecular complexes, vesicles, micelles, cells, optionally together with an associated volume element V having a size of 1008-06-2009
20090194705Producing Time Variation In Emanating Light - An excitation component or arrangement can provide excitation to a moving object so that information is encoded in time variation of light emanating from the object. For example, in each of a sequence of segments, it can provide a respective non-binary excitation spectrum, and the spectra can be different with a non-interference-like transition between them; because the object emanates light differently in response to the different spectra, photosensing results can be obtained that include encoded information about the object. The non-binary spectra could be different intermediate intensities, such as different gray levels or different intensities of one color or could be different colors. The excitation can be provided in a pattern with non-interference-like transitions between regions, and object motion can also be controlled. In another approach, a trigger signal can cause a time-varying excitation in a region, with non-interference-like transitions between intervals of excitation, such as black/white, multiple colors, or gray levels.08-06-2009
20110192990Measuring device for the measurement of bioluminescence, chemoluminescence or fluorescence of objects, irradiation device, measuring system, and method for the observation of plants - Described is a measuring device for the measurement of bioluminescence, chemoluminescence or fluorescence of objects. The measuring device comprises a light-tight housing (08-11-2011
20130037727FLUORESCENCE SENSOR - A fluorescence sensor includes a silicon substrate on which a PD element that converts fluorescence into an electric signal is formed, an LED substrate having a first principal plane on which an LED element that generates excitation light is formed, a reflective film that averages a light amount distribution of the excitation light radiated from a second principal plane of the LED substrate, and an indicator layer that receives the excitation light averaged by the reflective film and generates the fluorescence having a light amount corresponding to an analyte amount.02-14-2013
20130037726COMPACT ANALYZER WITH SPATIAL MODULATION AND MULTIPLE INTENSITY MODULATED EXCITATION SOURCES - A compact analyzer includes a flow cell having a flow channel through which a sample is made to pass. First and second light sources are arranged to emit first and second excitation light into first and second overlapping portions of the flow channel, respectively. The first excitation light stimulates a first light emission from particles of a first particle type that may be present in the sample; the second excitation light stimulates a second light emission from particles of a second particle type. A detector receives the first and second light emission from the corresponding particles present in the sample in a detection portion of the flow channel, and provides a detector output based on the received light emission. The light sources are modulated at different frequencies so that a frequency analysis of the detector output can provide separate information about the first and second particle types.02-14-2013
20130032734NON-UNIFORM GRATING - A system includes a non-uniform grating having a first region with a first refractive index and second regions with a second refractive index. A pattern of the second regions varies with an angular coordinate such that phase shifts of an incident beam created by the grating cause destructive interference that creates an intensity minimum within an output beam from the grating.02-07-2013
20100044583FILTER SET FOR OBSERVING FLUORESCENCE RADIATION IN BIOLOGICAL TISSUE - A filter set for observing fluorescent radiation in biological tissue includes at least one illumination filter and at least one observation filter. The at least one illumination filter is arrangeable in an illumination system of an optical system. The at least one least one observation filter is arrangeable in an imaging system of the optical system.02-25-2010
20080283770Illumination light detecting optical system and optical apparatus and endoscope apparatus provided with the same - An illumination light detecting optical system that is used for an optical apparatus comprises a light emitting element which emits excitation light; an insertion part of a long-narrow-shape; a fluorescence luminescence component arranged near a top of the insertion part; an excitation light guiding means which leads the excitation light emitted from the light emitting element to the fluorescence luminescence component; and a light detecting means which detects return light which is a part of the illumination light. It is provided with a pillar-shaped transparent component for irradiating illumination light arranged coaxially at a forward position of the fluorescence luminescence component; an illuminating-light-extracting-means for extracting the illumination light which enters at an angle smaller than a total reflection angle to the side surface of the pillar-shaped transparent component from the pillar-shaped transparent component, out of the illumination light which is emanated in forward direction from the fluorescence luminescence component and enters into the inside of the pillar-shaped transparent component; and a deflecting means by which the extracted illumination light is directed toward the light detecting means.11-20-2008
20090159814OBSERVING APPARATUS - An observing apparatus includes: a photographic unit that takes a region where cells are present as an observation object region based upon a macro image captured at low magnification of an interior of a cell culture vessel, and photographs the cells in the observation object region; an illuminating unit that irradiates light upon the cells only during photography by the photographic unit; and an output unit that outputs a fluorescent image photographed by the photographic unit while irradiating light only during photography by the illuminating unit.06-25-2009
20100108908WIREGRID MONITOR DEVICE - A device for monitoring radiation emitted by luminophores present in an analyte fluid of a wiregrid biosensor. The monitoring device comprises a non-polarized light source (05-06-2010
20100108909BATTERY - A battery includes a battery can housing an cell that supplies electrical energy at terminals of the cell by an electro-chemical reaction with oxygen, the can including, a first member having at least one hole that is exposed to air; and a second member. The battery also includes a mechanism coupled to one of the first and second members to move the one of the first and second members such that when current is drawn from the battery, the opening in the member allows air to pass into the battery, and to move the one of the first and second members such that when current is not drawn from the battery, the opening in the member is not in registration to inhibit air to pass into the battery. The battery also includes a circuit to control the mechanism. In one embodiment the circuit monitors levels of O05-06-2010
20130026390FLUOROSCOPY APPARATUS AND FLUORESCENCE IMAGE PROCESSING METHOD - Provided is a fluoroscopy apparatus comprising a white-light-image generating section that generates a white-light image of observation target, a fluorescence-image generating section that generates a fluorescence image of the observation target, a fluorescence-image correcting section that normalizes the fluorescence image with the white-light image, a displacement calculating section that calculates the displacement of the observation target from a plurality of white-light images generated at time intervals, a region-size calculating section that calculates the size of a region having a fluorescence intensity higher than or equal to a predetermined threshold value from the fluorescence image, and a control unit that controls the fluorescence-image correcting section so that, when the displacement of the observation target relative to the size of the region is larger than or equal to a predetermined proportion, normalization of the fluorescence image is stopped.01-31-2013
20130087718CONFOCAL FLUORESCENCE LIFETIME IMAGING SYSTEM - A confocal fluorescence lifetime imaging (FLIM) system comprising a pulsed tuneable excitation light source arranged to provide excitation radiation to an illumination area on a target, scanning means for scanning the illumination area across the target, and at least one detector for detecting fluorescent emission from the target, wherein the pulsed light source comprises a line forming unit arranged to form a line shaped illumination area of pulsed excitation light on the target, and wherein the detector comprises shutter means arranged to operate in synchronization with the pulsed light source enabling detection of time-resolved fluorescent emission intensity from the target.04-11-2013
20120181448PRODUCT MARKING - The present invention relates to a method for the authentication of a product, comprising providing said product with at least one marker, wherein said marker is a phosphorescent marker selected from a set of m phosphorescent markers each having a different emission spectrum, wherein m is an integer equal or greater than 3, and wherein said marker is provided at an amount that results in a phosphor-specific emission below background radiation emitted from said product.07-19-2012
20090045351SENSOR SYSTEM WITH SURFACE-PLASMON-POLARITON (SPP) ENHANCED SELECTIVE FLUORESCENCE EXCITATION AND METHOD - In a sensor system, an active sensor chip includes an array of periodically-patterned dielectric active sensor patches of different periodicities and geometries formed on a metal film. A specimen under study is positioned on each patch, and the active sensor chip is interrogated by illumination the patches in a predetermined sequence to result in a fluorescence response from each patch enhanced by SPP. The intensity of the fluorescence response is controlled by varying the wavelength, incidence angle, azimuthal orientation and polarization direction of the excitation light beam as the function of the periodicity of the illuminated patch. The system is compatible with commercial fluorescence microscopes and scanned laser interrogation systems.02-19-2009
20090302235FLUORESCENT NON-METALLIC PARTICLES ENCAPSULATED IN A METALLIC COATING - The present invention relates to a particle comprising a non-metallic core having a fluorescent material and a metallic shell encapsulating the non-metallic core wherein the metallic shell has transparency for an electromagnetic radiation having a first wavelength to excite the said fluorescent material and reflectance for an electromagnetic radiation having a second wavelength emitted by the said fluorescent material to confine the electromagnetic radiation having the second wavelength in the metallic shell. This system allows for the excitation of optical cavity modes inside the particle even at sub-micron particle size. The cavity modes are extremely sensitive to any change of the dielectric environment of the particle. This sensitivity can be used for the construction of optical nano-biosensors. Another application of the system is that of a microscopic source for spherical light waves, which may find applications in digital inline holography and display technology.12-10-2009
20120112094STIMULATED EMISSION-BASED OPTICAL DETECTION SYSTEM - The present invention provides an optical detection system comprising an illumination unit and a detection unit. The illumination unit comprises two laser beams of two different wavelengths. One beam is used to excite targeted molecules in a sample to their excited states. The other beam is used to induce the excited molecules in the sample to generate a stimulated emission signal. The stimulated emission signal can be used for long-distance detection due to its coherent property. Its extraction from the detection unit can be realized by demodulating the second beam's intensity change.05-10-2012
20100084570TERAHERTZ WAVE GENERATOR - Provided is a terahertz wave generator that improves efficiency of generating a terahertz wave. The terahertz wave generator includes a generating layer for generating the terahertz wave, a waveguide layer for propagating excitation light entering the generating layer and a terahertz wave generated by the excitation light entering the generating layer, and a first confinement layer for confining in the waveguide layer the excitation light propagating in the waveguide layer and the terahertz wave propagating in the waveguide layer. The generating layer, the waveguide layer, and the first confinement layer are laminated in the stated order.04-08-2010
20120223250LUMINESCENT SOLAR CONCENTRATOR - The present invention relates to a luminescent solar concentrator for a solar cell, comprising a collector with a luminescent substrate, and a wavelength selective filter, wherein the wavelength selective filter is arranged above the surface of the collector, wherein the luminescent substrate has an absorption edge which corresponds to a wavelength λ09-06-2012
20110012026PLANAR OPTICAL WAVEGUIDE WITH CORE OF LOW-INDEX-OF-REFRACTION INTERROGATION MEDIUM - An apparatus for illuminating a sample includes a planar waveguide. The planar waveguide includes a first substrate, including a first outer surface and a first inner surface, and a second substrate, including a second outer surface and a second inner surface. The first and second inner surfaces of the first and second substrates, respectively, are spaced apart from each other and partly define a volume for confining the sample therein. The apparatus also includes a light source for providing light directed toward the planar waveguide, such that the light is optically coupled to and contained within the planar waveguide between the outer surfaces of the first and second substrates, while illuminating at least a portion of the sample confined within the volume.01-20-2011
20110012025FLUORESCENCE OBSERVATION APPARATUS - A fluorescence observation apparatus according to the present invention includes a light source section that can emit a plurality of excitation light beams of different wavelength bands and select excitation light beams to be emitted to an object where there are a first fluorescent substance and a second fluorescent substance to be examined from among the plurality of excitation light beams, a variable filter section that selectively allows at least part of the wavelength band of returning light from the object to pass, a photo-detecting section that detects the light that has passed through the variable filter section, a calculation processing section that carries out calculations to determine a wavelength band of the excitation light emitted from the light source section and a transmission wavelength band in the variable filter section based on intensity characteristics of the plurality of excitation light beams, fluorescence characteristics of the first fluorescent substance and fluorescence characteristics of the second fluorescent substance and a control section that performs control of causing the light source section to interlock with the variable filter section based on the calculation result of the calculation processing section.01-20-2011
20130161533BIOCHIP ANALYSIS DEVICE - Disclosed is a biochip analysis device which includes first and second spatial light modulators; and a spatial light modulation driver configured to drive the first and second spatial light modulators, wherein the first spatial light modulator varies a wavelength of light to be irradiated to a biochip in response to a control of the spatial light modulation driver and the spatial light modulator passes a fluorescence signal selected from fluorescence signals generated by the biochip in response to a control of the spatial light modulation driver.06-27-2013
20130161534METHOD OF MANUFACTURING WHITE LIGHT EMITTING DEVICE (LED) AND APPARATUS MEASURING PHOSPHOR FILM - A method of manufacturing a white light emitting device includes dividing a phosphor sheet into phosphor film units to be applied to individual light emitting diode (LED) devices, measuring light conversion characteristics of the respective phosphor film units, classifying the phosphor film units of the phosphor sheet into a plurality of groups according to measurement results of the light conversion characteristics and combining the phosphor film units classified into the plurality of groups and an LED device having predetermined light characteristics so as to obtain target color characteristics.06-27-2013
20130161535FIBRE OPTIC PHOSPHOR SCREEN COMPRISING AN ANGULAR FILTER - An optical fiber phosphor screen including a thin film phosphor layer and an optical fiber faceplate, allowing interfering light in a cladding of the optical fibers to be reduced. The phosphor screen includes an angular filter including at least one layer arranged between the thin film phosphor layer and the optical fiber faceplate.06-27-2013
20090236541System and Methods for Optical Imaging - The invention relates to imaging methods and systems. The systems may comprise a white light source configured to generate light in a first wavelength range, an excitation source configured to generate light at one or more wavelengths for exciting a fluorescent substance, a first detector configured to acquire reflectance image data that represents white light reflected from a subject, and a second detector configured to acquire fluorescence image data that represents fluorescence emissions from the subject. At least one of the one or more wavelengths generated by the excitation light source is within the first wavelength range of the white light source. The fluorescent substance may be, for example, a fluorescent dye that is injected into a patient before or during a surgery. The system may also include an image processing engine and a display. The image processing engine may receive the reflectance image data and the fluorescence image data and generate a merged image in which the fluorescence image data is superimposed on the reflectance image data. The display may be used by a surgeon, for example, to more effectively visualize the surgical site during surgery.09-24-2009
20130068965BIOFUEL DEGRADATION SENSOR BASED ON FLUORESCENCE MEASUREMENTS - A sensor that detects a fuel property of a mixed fuel of a biofuel and a hydrocarbon fuel includes: a light emitting device that emits light with a wavelength of 250 nm to 400 nm onto the mixed fuel; and a light receiving device that receives light emitted by the mixed fuel under the effect of light from the light emitting device and generates an output corresponding to the received light. When the fuel property is determined, in a case where the mixed fuel is irradiated by light with a predetermined wavelength generated due to voltage application to the light emitting device, the light emitted by the mixed fuel is detected by the light receiving device. The fuel property of the mixed fuel is detected according to the detected light.03-21-2013
20130068966ADJUSTABLE CATHODOLUMINESCENCE DETECTION SYSTEM AND MICROSCOPE EMPLOYING SUCH A SYSTEM - Cathodoluminescence detection system comprising a collecting optic (03-21-2013
20130214175Optical sensor, especially for determining substance concentrations in aqueous solutions by means of a fluorescence measurement - An optical sensor, comprising a sensor head, which contains a sensitive element and which is adjoined by a housing, which contains sensor electronics, wherein the sensitive element is irradiated with light from an optical transmitter and a light characteristic radiated back by the sensitive element is detected by an optical receiver and evaluated by the sensor electronics. The sensor head and the housing are embodied to be separable, wherein different sensor heads having different sensitive elements are connectable to the housing containing the sensor electronics and the sensor electronics evaluates the light characteristics generated by the different sensitive elements.08-22-2013
20110042581Fluorescence Detector - A fluorescence detector is provided to improve the non-linearity of the relationship between concentration and fluorescence intensity when the specimen concentration is high and thereby improve the dynamic range of the measurements. If it is known that the concentration of the specimen to be measured is high, a light beam restriction unit 02-24-2011
20090189087MEASURING DEVICE AND MEASURING METHOD - A measuring device includes a light source, a holding member for holding a sample, a first concave mirror and a second concave mirror, the second concave mirror being arranged on the light path from the light source to the holding member, the first concave mirror being arranged vis-a-vis the second concave mirror with the holding member interposed between them, the first concave mirror and the second concave mirror being arranged with their concave surfaces facing each other, the first concave mirror being larger than the second concave mirror in terms of their outer dimensions.07-30-2009
20100207035FLUORESCENCE BASED SENSORS UTILIZING A MIRRORED CAVITY - A fluorescence based sensor system that provides improved signal-to-noise over prior systems is provided. The system includes a fluorescence based sensing medium that is contained a recessed cavity with reflective sides that allow for more uniform excitation of the fluorescence based sensing medium by the excitation light.08-19-2010
20110284765OPTICAL BACKGROUND SUPPRESSION SYSTEMS AND METHODS FOR FLUORESCENCE IMAGING - A fluorescence imaging system having an enclosure having an optical excitation and detection system and features designed to suppress or reduce background fluorescence. In certain aspects, all or a portion of the interior walls has a material finish and texture that provides a surface that absorbs at least a portion of any impinging excitation light and which has low auto-fluorescing properties. In certain aspects, a baffle structure is provided on the interior of the structure and is configured to mask portions of the interior and reduce the opening through which light impinges on the detector. In certain aspects, a platform having an optically transparent window is located in the interior of the housing structure for holding a sample for excitation by excitation light from an excitation source, wherein a light-trap structure is positioned or located on an opposite side of the platform relative to the excitation source and configured to receive and contain a substantial portion of any scattered or transmitted excitation light.11-24-2011
20110284766LIGHT IRRADIATION DEVICE AND LIGHT MEASUREMENT DEVICE - The present invention relates to a light irradiation apparatus and the like which can reduce background light noise from a plurality of wells provided on a microplate. The light irradiation apparatus comprises a microplate (11-24-2011
20110291025FLOW CYTOMETRY ANALYSIS ACROSS OPTICAL FIBER - An apparatus and method for analyzing a fluid with particle analytes, where the fluid is fed through a passageway within an optical fiber and excitation light is guided by the optical fiber across the passageway and intersects the fluid therein. The optical core is made multimode and is adapted to shape the excitation light with a uniform spatial illumination over a cross-section of the optical core and the passageway is configured relative to the optical core such that the particle analytes are exposed to substantially equal excitation light while circulating in the passageway.12-01-2011
20110291026OPTICALLY ACCESSIBLE MICROFLUIDIC DIAGNOSTIC DEVICE - A microfluidic diagnostic device (12-01-2011
20110140001HIGH THROUGHPUT FIBER OPTICAL ASSEMBLY FOR FLUORESCENCE SPECTROMETRY - System for high-throughput detection of the presence of an analyte of interest in a sample, said system comprising a multi-well plate sample container; an automated means for successively transporting samples from the multi-well plate sample container to a transparent capillary contained within a sample holder; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the capillary, and wherein the radiation induces a signal which is emitted from the sample; and, at least one linear array comprising: a proximal end disposed in proximity to the sample holder and a single end port distal from the proximal end; a plurality of optical fibers extending from the proximal end to the end port and having a first end and a second end, wherein the first ends of the individual optical fibers are arranged substantially parallel and adjacent to one another, and wherein the second ends of the optical fibers form a non-linearly arranged bundle, and wherein the plurality of optical fibers transmits the fluorescent signal from the proximal end to the end port; and an end port assembly optically coupled to the end port, the end port assembly comprising a single photo-detector, wherein the photo-detector detects the fluorescent signal and converts the fluorescent signal into an electrical signal.06-16-2011
20120097864FLUORESCENCE ANALYZING APPARATUS AND FLUORESCENCE DETECTING APPARATUS - Provided are a method and an apparatus for easily identifying and detecting fluorescent material types captured in respective reaction regions of a substrate, particularly, a method and an apparatus for identifying and measuring the fluorescence intensities of a plurality of fluorescent materials using a small pixel count. The fluorescence intensities of four or more types of fluorescent materials are divided by a dividing section at ratios different at least for each fluorescence maximum wavelength range, and are detected by at least one detector including pixels for detecting the light fluxes divided at the different ratios. The type of the fluorescent material is determined on the basis of the ratio of the detected fluorescence intensity of the same detection portion, and the fluorescence intensity is measured.04-26-2012
20080308744Serum Albumin Conjugated to Fluorescent Substances for Imaging - Compositions and methods are disclosed for imaging tissue or a lymphatic or circulatory system, for example, in the near infrared. Dyes that emit wavelengths in the infrared or near infrared regions of the spectrum may be employed on their own, as combinations or complexed with serum albumin, or as part of a covalent conjugate with serum albumin.12-18-2008
20120025097Workpiece Characterization System - A workpiece characterization system for obtaining simultaneous measurement of layer and photoluminescence properties of a workpiece. The workpiece characterization system includes an excitation light and an illumination light each impinging upon a surface of a workpiece whereby the workpiece emits photoluminescent light and encodes light from said illumination source with layer information. The excitation light and the illumination light are generated from a single light source. The light from the single light source is filtered to remove wavelengths of light that correlate to light wavelengths emitted from the workpiece as a result of excitation. Wavelengths that correlate to light reflected from the workpiece that may contain encoded information are not filtered.02-02-2012
20090189088Fluorescence-activated cell detector - An apparatus for detecting particles of interest that are dispersed in a fluid mix, which typically includes other particles. The apparatus typically is associated with an interrogation platform arranged to operate in harmony with an opaque member having an orifice sized to promote single-file travel of the particles there-through. A currently preferred embodiment includes a light pipe configured to impinge stimulation-radiation substantially transverse to a direction of fluid flow through the opaque member. Particles of interest may be tagged using antibody-binding, fluorescing molecules. Stimulation radiation from the source causes the tagged particles to undergo a Stokes-shift emission of fluorescence. The resulting fluorescence is detected by the radiation detector and indicates passage of the particles of interest. One workable opaque member is advantageously included in a thin film assembly carried on a removable and disposable card that is adapted for reception in the interrogation platform.07-30-2009
20090146076BIOASSAY SYSTEM INCLUDING OPTICAL DETECTION APPARATUSES, AND METHOD FOR DETECTING BIOMOLECULES - A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. The light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian. The optical detection apparatus may further include an excitation light source formed over the substrate so as to provide a light source for exciting a fluorophore attached to the biomolecule.06-11-2009
20090146077SYSTEM OF FLUORESCENCE ANALYSIS OF A FIELD IN AN ILLUMINATED AREA - A system of analysis with the naked eye and by fluorescence of a field in an illuminated area comprising a periodically-excited first low-remanence white light illumination source; a second light source for exciting fluorescent elements located in said field, active at least during part of the time periods when the first source is off; and a fluorescence analysis device active during time periods when the first source is off and the second source is on.06-11-2009
20100012852IMAGE READING DEVICE AND IMAGE FORMING APPARATUS - The present invention aims at providing an image reading device and an image forming apparatus including a light guiding body having a first emission surface and a second emission surface. A color copy machine includes a luminescence portion including: LEDs composed of a plurality of dot-shaped luminescence members disposed at predetermined intervals in a main scanning direction and/or an elongated luminescence member that is formed to extend in the main scanning direction; and a light guiding body that is disposed between the LEDs and an original, and has a light incidence portion disposed on a side to the LEDs and an emission portion disposed on a side to the original. The emission portion has a first emission surface and a second emission surface that is formed on a different plane from a plane including the first emission surface.01-21-2010
20100078575Versatile Surface Plasmon Resonance Analyzer with an Integral Surface Plasmon Resonance Enhanced Fluorescence Mode - An instrument for measuring and analyzing surface plasmon resonance on a sensor surface has a polarized light source optically connected to the sensor surface by a plurality of optical elements, including in one embodiment an optical telescope that transfers light from a rotatable reflecting surface to the sensor surface. Selective positioning of a cylindrical lens into a first position within the path of light transforms collimated light to a rectangular wedge that is incident upon the sensor surface at numerous angles. In another embodiment, the light source is operated as a laser to excite fluorescence on the sensor surface and the fluorescence is selectively directed to a detector by appropriate optical elements positioned in specific configurations.04-01-2010
20100090126Fluorometers - In apparatus for the production and detection of fluorescence at a sample surface, the height of the apparatus above the sample surface is reduced, and loss of the emitted fluorescence due to reflection loss and light scattering is minimized. The apparatus comprises a three-dimensionally curved light reflecting surface (04-15-2010
20110168912OPTICAL SYSTEM FOR DOSIMETER READER - Described is an optical system for a dosimeter reader having reduced sensitivity to vibration and motion.07-14-2011
20090250628FLUORESCENCE DETECTING APPARATUS AND FLUORESCENCE OBSERVATION SYSTEM - A fluorescence detecting apparatus includes a light detecting device disposed in a light path of fluorescence generated in an illuminated area of a specimen and a barrier filter disposed in the light path toward the light detecting device to exhibit transparency for each of a plurality of fluorescences having separated wavelength bands.10-08-2009
20090278055Real-Time, On-Line Analysis of Haloacetic Acid Species and Amounts Thereof in Drinking Water Supplies - Post-column reaction-ion chromatography (PCR-IC) analysis of drinking water samples for quantity measurements and species identification of haloacetic acid contaminants therein is provided. With the necessity to chlorinate drinking water to remove harmful bacteria and other potential toxins, haloacetic acid byproducts are generated that may harm humans after consumption as well. A reliable manner of measuring such drinking water supplies for haloacetic acids at locations far from the source and closer to dispensers is highly desirable. The PCR-IC analysis method of the invention has been found to be nearly as reliable as source measuring methods for the same purpose, but with the versatility to measure for such haloacetic acid contaminants anywhere along the drinking water supply line.11-12-2009
20110140000SUPER-RESOLUTION MICROSCOPE - Provided is a super-resolution microscope for observing a specimen containing a substance having two or more excited quantum state, which includes: a light source section that outputs a first illumination light for exciting the substance from a stable state to a first quantum state, and a second illumination light for further transitioning the substance to other quantum state; an optical system including a microscope objective lens and condensing the first illumination light and the second illumination light, each outputted from the light source section, onto the specimen in a manner that these lights are partially overlapped with each other; a detection section that detects an optical response signal emitted from the specimen in response to condensing of the first illumination light and the second illumination light; and, a polarization controlling element provided with a polarizing member that converts a polarization state of the first illumination light or the second illumination light, and a phase modulation section integrally formed with the polarizing member and spatially modulating a phase of the second illumination light.06-16-2011
20090283698Hand-Held Probe for Intra-Operative Detection of Fluorescence Labeled Compounds and Antibodies - A hand-held probe for intra-operative detection of fluorescence labeled compounds includes a housing comprising a handle and a columnar portion, and a power source within the housing. A light emission source proximate the columnar portion of the housing is configured to fluoresce at least one of predetermined compounds and predetermined antibodies. An excitation switch proximate the handle selectably activates the light emission source. A detector receives fluorescent light emissions directed toward the columnar portion from at least one of the compounds and antibodies and convert the fluorescent light emissions to a corresponding emission electrical signal. A controller within the housing receives the emission electrical signal from the detector and converts the emission electrical signal to a corresponding data signal. Finally, a data port within the housing receives the data signal from the controller, converts the data signal to a corresponding output signal, and transmits the output signal.11-19-2009
20090283697SYSTEM AND METHOD FOR MONITORING BLUE-GREEN ALGAE IN A FLUID - A particle detection system with a detection mechanism that includes detectors positioned to detect two different ranges of fluorescence produced by particles in the fluid in a flow chamber. Each of the detectors is arranged to generating a trigger signal whenever fluorescence is detected. The system and related method enhance the accuracy and sensitivity of blue-green algae monitoring by utilizing imaging flow cytometry combined with particle analysis and the measurement of the ratio of each particle's phycocyanin to chlorophyll b detected by using the two detectors configured for detection of two different fluorescence ranges, one associated with the phycocyanin and the other associated with the chlorophyll b. Optionally, captured images may be used in comparison to known images of a library of images.11-19-2009
20090289198SYSTEMS AND METHODS FOR ACOUSTIC SENSING - An optical-based acoustic sensor system detects sound. An exemplary embodiment has a substrate with a surface and an internal region; a shell disposed above the substrate surface, the shell operable to receive incident light emitted by a light source; a beam disposed blow the shell; a photodiode on the substrate surface below the beam, and in response to receiving a first portion of light, the photodiode is operable to generate a charge that attracts the beam such that a motion is induced in the beam to cause the beam to resonate; and a microphone device coupled to the shell, the microphone device operable to detect acoustic waves, and operable to modulate the vibratory motion of the beam, wherein a second portion of light is modulated by the vibratory motion of the beam to generate sound-modulated light that is emitted from the sensor.11-26-2009
20120292530FLUORESCENCE OBSERVATION DEVICE - In a fluorescence observation device, a light source device generates illumination light and excitation light to be radiated onto an examination subject; a white-light image data acquisition unit generates a white-light image by capturing reflected light coming from the examination subject; a fluorescence image data acquisition unit generates a fluorescence image by capturing fluorescence generated at the examination subject; a quantification computation unit computes normalized fluorescence intensities, which are brightness values of individual pixels in the fluorescence image normalized by brightness values of corresponding pixels in the white-light image; a standard-data memory stores standard data indicating a typical correspondence relationship between the normalized fluorescence intensities and states of the examination subject; and an image-correction computation unit judges the states of the examination subject that correspond to the individual normalized fluorescence intensities on the basis of a minimum value of the normalized fluorescence intensities and the standard data.11-22-2012
20120085929Multispectral Illumination Device - An illumination device includes at least four semiconductor radiation sources (04-12-2012
20120091364OPTICAL LEAK DETECTOR FOR SUBSEA EQUIPMENT - A leak detector (04-19-2012
20110140002Photoluminescent Compositions, Methods of Manufacture and Novel Uses - A novel marking system is provided. The marking includes photoluminescent materials and provides for shifting of excitation energy. The marking provides flexibility for identification and tracking, both in stealth and non-stealth appearances.06-16-2011
20110266457SYSTEM FOR NIGHT VISION OF SELECTED OBJECTS - System for providing an enhanced night vision of an object such as the refuelling device (11-03-2011
20080290292Fluorescence-Based Detection Methods and Apparatus - In apparatus for detecting the emission of fluorescent radiation from a sample in response to excitation by two or more different radiation sources (11-27-2008
20080302975SURFACE PLASMON ENHANCED FLUORESCENCE SENSOR - Exciting light is irradiated through a dielectric material block toward an interface between the dielectric material block and a metal film formed on one surface of the dielectric material block, such that total reflection conditions may be satisfied. An intensity of analysis fluorescence produced by an analysis fluorescent substance, which is contained in a sample and produces the analysis fluorescence by being excited by an evanescent wave oozing out from the interface when the exciting light impinges upon the interface, is normalized in accordance with an intensity of reference fluorescence produced by a reference fluorescent substance, which has been located at a position for excitation by the exciting light.12-11-2008
20120292529STROBOSCOPIC OPTICAL IMAGE MAPPING SYSTEM - The present invention provides a stroboscopic optical image mapping system comprising a control module, an optical module, and an image acquiring unit. The control unit forms a delayed pulse signal by modulating a first pulse signal having a plurality of pulses with a pulse period, wherein a time interval between two adjacent pulses of the delayed pulse signal has a time difference with respect to the pulse period. The optical module provides an incident light to be projected on an organic object, which has a dye therein and is stimulated by a second pulse signal for generating a sequential action potential. The fluorescence generates from the dye inside the organic object, which corresponds to the intensity of the sequential action potential. The image acquiring unit is actuated to acquire the fluorescent light according to the delayed pulse signal, thereby forming a plurality of fluorescent images.11-22-2012
20110204256HIGH-SPEED CELLULAR CROSS SECTIONAL IMAGING - A cross sectional imaging system performs high-resolution, high-speed partial imaging of cells. Such a system may provide much of the information available from full imaging cytometry, but can be performed much more quickly, in part because the data analysis is greatly reduced in comparison with full image cytometry. The system includes a light source and a lens that focuses light from the light source onto a small spot in a scanning location. A transport mechanism causes relative motion between a cell in the scanning location and the spot. A sensor generates a signal indicating the intensity of light emanating from the cell as a result of illumination by the light source. The system repeatedly takes readings of the light intensity signal and characterizes the light intensity along a substantially linear path across the cell.08-25-2011
20080308745Device for Optical Excitation Using a Multiple Wavelength Arangement - The invention relates to a device for optical excitation, in particular luminescent excitation of biomolecules (12-18-2008
20090032731PHOTODETECTOR AND MEASUREMENT OBJECT READER - Provided is a photodetector 02-05-2009
20130119270WAVELENGTH DIVISION DEVICES, MULTI-WAVELENGTH LIGHT GENERATORS AND OPTICAL BIOSENSOR SYSTEMS USING THE SAME - A multi-wavelength light generator includes a broadband light source and a wavelength division device. The multi-wavelength light generator is configured to generate a first output light having a first line width. The wavelength division device is configured to divide a wavelength of the first output light to provide a plurality of second output lights. Each of the second output lights has a second line width narrower than the first line width, and each of the second output lights is used as a light source of each channel of an optical sensor.05-16-2013
20080290293FLUORESCENCE MICROSCOPE APPARATUS - To observe and analyze intermolecular interactions such as diffusion and/or binding behaviors of molecules in a sample in a reacting state against optical stimulation, while applying the optical stimulation to a desired region in the sample by irradiating stimulus light. There is provided a fluorescence microscope apparatus comprising: a fluorescence image-capturing optical system for capturing fluorescence images of a sample; a stimulus light-irradiation optical system which includes a scanner for applying optical stimulation to an optional region in the sample by irradiating stimulus light; a control unit which acquires temporal observation data by repeatedly capturing images using said image-capturing optical system while applying optical stimulation using the stimulus light-irradiation optical system; an analysis unit which analyzes intermolecular interactions through analysis of changes in fluorescence intensity caused by molecular fluctuations within a confocal volume with use of the temporal observation data; and a display unit which displays an analysis result from the analysis unit.11-27-2008
20080272311Improved Reversible, low cost, distributed optical fiber sensor with high spatial resolution - A spectroscopic based optical fiber sensor includes a sensitive optical fiber, a probing light source, a power supply, a detector means, a signal processing means, and a display means. The sensitive optical fiber is optically affected by the presence of at least one measurand. The probing light source, adjacent to the sensitive fiber, transversely illuminates the fiber from the outside. The probing light is modified by the sensitive fiber, coupled into the optical fiber core, either as bound modes or leaky modes, as a light signal and guided to a detector means located at the terminus of the optical fiber. The detector means correlates the intensity of the light signal with an electric signal and transmits the electric signal to the signal processing means, wherein the electric signal is correlated to the quantity being measured. The correlated quantity being transmitted and displayed on the display means.11-06-2008
20080265175Device for Detection of Excitation Using a Multiple Spot Arrangement - The invention relates to a device (10-30-2008
20110006217LASER SCANNING MICROSCOPE - A fluorescence detection unit measures light quality of fluorescence from a sample excited by irradiation of a laser beam, and a transmitted light detection unit measures light quantity of the laser beam transmitted through the sample. A CLEM processing unit stops irradiation of the laser beam at every one pixel correspondence range scanning time, in one of a case where light quality of fluorescence at a lower limit value determination time is less than a lower limit threshold, and a case where light quantity of fluorescence is an upper limit threshold or more during the one pixel correspondence range scanning time. The CLEM processing unit extrapolates light quantity of the transmitted light that is supposed to be measured if exposure is performed for the one pixel correspondence range scanning time, and an image obtaining unit obtains a transmitted light image based on the extrapolated light quantity.01-13-2011
20080258077Superresolution in microlithography and fluorescence microscopy - In scanned optical systems such as confocal laser microscopes wherein a beam of light is focused to a spot in a specimen to excite a fluorescent species or other excitable specie in the spot, the effective size of the excitation is made smaller man the size of the spot by providing a beam of light of wavelength adapted to quench the excitation of the excitable species, shaping this second beam into a pattern with a central intensity minimum, and overlapping this central minimum with the central intensity maximum of the focused spot, so that within the spot the intensity of quenching light increases with distance from the center of the spot thereby preferentially quenching excitation in the peripheral parts of the spot, and thereby reducing the effective size of the excitation and thus improving the resolution of the system. In the preferred embodiment of the present invention, the central minimum of quenching light is narrowed further by creating the pattern of quenching radiation in the specimen by imaging onto the focal plane a plurality of pairs of sources of quenching light, arrayed at the vertices of a regular, even-sided polygon, the center of which is imaged in the specimen on the central maximum of exciting radiation, and such that the two members of each pair are on opposite vertices of the polygon and emit light mutually coherent and out-of-phase, and the light emitted by different pairs is incoherent with respect to each other.10-23-2008
20090084980SYSTEM AND METHOD FOR PROVIDING ENHANCED BACKGROUND REJECTION IN THICK TISSUE WITH DIFFERENTIAL-ABERRATION TWO-PHOTON MICROSCOPY - A system for providing enhanced background rejection in thick tissue contains an aberrating element for introducing controllable extraneous spatial aberrations in an excitation beam path; at least one mirror capable of directing received laser pulses to the aberrating element; an objective; a beam scanner imaged onto a back aperture of the objective so that the beam scanner steers beam focus within the thick tissue; and a detector for recording signals produced by the tissue. An associated method comprises the steps of acquiring two-photon excited fluorescence of thick tissue without extraneous aberrations; introducing an extraneous aberration pattern in an excitation beam path; acquiring two-photon excited fluorescence of the thick tissue having the introduced extraneous aberration pattern; and subtracting the two-photon excited fluorescence with extraneous aberrations from the acquired standard two-photon excited fluorescence of the thick tissue without extraneous aberrations.04-02-2009
20090140167NANOTUBE FABRIC-BASED SENSOR SYSTEMS AND METHODS OF MAKING SAME - Under one aspect, a system (06-04-2009
20090050821Apparatus for analyzing particles in urine and method thereof - An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing a first stain reagent and the first aliquot; a second specimen preparing section for preparing a second specimen for measuring bacteria by mixing a second stain reagent and the second aliquot; and an optical detecting section comprising a light source for irradiating a light to a specimen being supplied, a scattered light receiving element for detecting scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen. A method intended for use in analyzing particles in urine is also disclosed.02-26-2009
20090084979High-speed molecular analyzer system and method - This invention relates to a device, in one example embodiment, for the determination of the sequence of nucleic acids and other polymeric or chain type molecules. The device analyzes a sample prepared by incorporating fluorescent dyes at the end of copies of varying lengths of the sample to be sequenced. The sample is then vaporized, charged and accelerated in an evacuated chamber. The individual molecules of the sample are accelerated to different velocities because of their different masses, which cause, in one embodiment, the molecules to be sorted by length as they travel along the evacuated chamber. Once sorted, the stream of molecules is illuminated causing the fluorescent dyes to emit light that is picked up by a detector. The output of the detector is then processed by a computer to yield of the sequence of the sample under analysis. Such an embodiment improves over the art by using photo-detection of the individual molecules instead of measuring the time of flight to a detector that measures collisions. Unlike mass spectrometry, the method of such an embodiment does not require the extreme sensitivity required to differentiate between very small mass differences in large molecules. Such an embodiment is therefore more robust than the art and well suited for high throughput sequencing of, for example, various large nucleic acid molecules.04-02-2009
20120104278System And Method For The Excitation, Interrogation, And Identification Of Covert Taggants - Apparatuses and methods relating to excitation, interrogation, and identification of covert taggants, are described. In one exemplary embodiment, a multi-measurement interrogator comprising an emitter and an optical sensing subsystem that is capable to sense more than one type of a response signal from a taggant is described. The multi-measurement interrogator may interrogate the taggant multiple excitation wavelengths, acquire more than one type of the response signal from the taggant, and perform quantitative measurements of the response signal. Another exemplary embodiment of the invention describes an eye-safe interrogator that includes a light emitting diode (LED), wherein LED is capable to stimulate one or more of an upconversion fluorescence and a Stoke's fluorescence from the taggant. Another exemplary embodiment of the invention provides a portable, hand-held covert interrogator, which utilizes invisible light both to excite the taggant and to receive a response from the taggant.05-03-2012
20090242797SYSTEM AND METHOD FOR MULTI-MODE OPTICAL IMAGING - A technique is provided for multi-mode optical imaging. The technique includes directing a visible light and an excitation light multiplexed in time towards a specimen. The excitation light is configured to induce luminescence in the specimen. The technique also includes detecting visible light scattered or reflected from the specimen and luminescent light emitted via luminescence via a single detector that is in synchronization with the one or more illumination sources.10-01-2009
20090121153Single wavelength stimulated emission depletion microscopy - In apparatus for superresolution microscopy or microlithography, wherein a spot in the specimen to be examined or in the microlithographic medium is raised to an excited state by a first pulse of light, and a second pulse of light reduces the excitation in the peripheral parts of the spot to increase the resolution of the instrument, a method whereby the wavelength of the second pulse in the specimen or medium is the same as the wavelength of the first pulse, thereby allowing the cost and complexity of the apparatus to be lowered.05-14-2009
20100187438Fluorescent Light Microscope For Measuring a Sample Using Red-Shifted Stokes Lines - A fluorescent light microscope for measuring a sample comprises a light source providing transfer light having a transfer wavelength for transferring a fluorescent dye in the sample from one state into another state, and a detector which measures fluorescent light from the sample with spatial resolution. The light source comprises a laser, an optical wave guide connected to the laser, and a wavelength-selective device connected to the optical wave guide. The laser emits pump light of a pump wavelength other than the transfer wavelength and injects the pump light into the optical wave guide. The pump light, due to Raman scattering being stimulated in the optical wave guide, generates a light spectrum emerging from the optical wave guide which has, besides the pump wavelength, at least one red-shifted Stokes line whose full width at half maximum is smaller than half of its distance to its next neighbor line on the blue side of the spectrum; and the wavelength-selective device singles out the transfer light by its transfer wavelength from the red-shifted Stokes lines of the light spectrum.07-29-2010
20110174986Apparatus, Especially Microscope, for the Analysis of Samples - Disclosed is an apparatus, especially a microscope, characterized by a diffraction-limited resolution volume, comprising multiple dye molecules (UF) that can be switched between different states, at least one of which is fluorescent. The fluorescence is focused using an objective lens (O) and is imaged onto a spatially resolving detector. In at least one portion of the sample, the UF have a distribution density that is greater than the inverse of the diffraction-limited resolution volume. Said apparatus further comprises one or more light sources for emitting a switching radiation in order to switch a first subset of the UF in the sample, and for emitting an excitation radiation in order to excite the first subset of UF. A phase mask which generates a light distribution (PSF) having an at least partially limited local minimum radiation on the detector plane is provided in the beam path, preferably in the detection beam path. Alternatively, an axicon is provided for generating a Bessel distribution (PSF) on the detector plane, a means for structuring the illumination distribution is provided in the illumination beam path, means for spectrally splitting the sample light are provided in the detection beam path, a receiver array composed of position-sensitive receivers is provided for detection purposes, means causing a color-dependent light distribution (PSF) on the detector plane are provided in the detection beam path, or an achromatic beam splitter is arranged in or near the pupil.07-21-2011
20100213387PORTABLE CORROSION DETECTION APPARATUS - A method and apparatus comprising a housing, an excitation unit, and a detector. The housing is portable and capable of being positioned relative to a location on an object. Quantum dots are present in the location. The excitation unit is mounted to the housing. The excitation unit is capable of sending energy into the location in which the energy is capable of causing a response from the quantum dots. The detector is mounted to the housing. The detector is capable of detecting the response from the quantum dots in the location.08-26-2010
20100243915FLUORESCENCE DETECTION SYSTEM - A fluorescence detection system capable of detecting fluorescence with a high sensitivity even if a sample generating fluorescence is small in amount includes a light source emitting excitation light, a probe arranged in opposition to a sample unit, an optical multiplexer/demultiplexer, a detector, a first optical fiber connecting the light source to the optical multiplexer/demultiplexer, a second optical fiber connecting the probe to the optical multiplexer/demultiplexer, and a third optical fiber connecting the detector to the optical multiplexer/demultiplexer. An excitation filter, serving as a short-pass filter, is arranged on the first optical fiber and a detection filter serving as a long-pass filter is arranged on the third optical fiber. The optical multiplexer/demultiplexer includes a multiplexing/demultiplexing filter serving as a long-pass filter.09-30-2010
20080277595Highly multiplexed confocal detection systems and methods of using same - Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high density optical systems to illuminate high density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.11-13-2008
20100001207Probe Array and Method of Manufacturing the Same - A probe array includes a probe-carrying substrate and a base member. The probe-carrying substrate has first and second principal surfaces extending parallel to each other, and a plurality of probe carriers carrying probe molecules. The base member has a reference surface extending parallel to a fluorescence-receiving surface, and a seating surface supporting the probe-carrying substrate and extending in a direction other than a direction parallel to the reference surface. The probe carriers each have a plurality of surfaces forming different angles with respect to the fluorescence-receiving surface, the plurality of surfaces including a bottom surface and uprising surfaces extending from the bottom surface. Accordingly, the plurality of surfaces have different sensitivities, realizing a wide dynamic range.01-07-2010
20100252747FLUORESCENCE DETECTION DEVICE - A fluorescence detection device is configured to detect a fluorescent substance which is attached to an inspected medium and glows at a specific wavelength. The detection device includes an illumination device configured to apply excitation light for exciting a fluorescent substance to an inspected medium, a first photoreceptor configured to receive excited light from the fluorescent substance of the inspected medium and detect only light of a specific wavelength, a second photoreceptor configured to receive excited light from the fluorescent substance of the inspected medium and detect light in a wider frequency band including the specific wavelength, and an authentication section configured to authenticate the fluorescent substance based on detection signals from the first and second photoreceptors.10-07-2010
20130126753X-RAY IMAGING PANEL WITH THERMALLY-SENSITIVE ADHESIVE AND METHODS OF MAKING THEREOF - Provided herein are scintillator screens comprising a substrate; a scintillation layer disposed over the substrate, the scintillation layer comprising a scintillator material; and an adhesive layer disposed by solvent coating over the scintillation layer, the adhesive layer comprising solvent-coatable thermally-sensitive elastomer, wherein the adhesive layer has a dust adhesion of ≦1 dust particles/
20110057117OPTICAL SYSTEM FOR MULTIPLE REACTIONS - Optical systems, and corresponding methods, for multiple reactions are provided. The optical systems are in a fixed position relative to a thermal assembly and include at least one array of excitation sources (e.g., light emitting diodes (LEDs)) configured to output excitation energy along an excitation optical path. In addition, a detector configured to receive emission energy along a detection optical path in the same plane as the excitation optical path is also provided.03-10-2011
20110057116FLUORESCENCE DETECTION OF NITROGEN-CONTAINING EXPLOSIVES AND BLUE ORGANIC LED - The invention provides a sensor for detecting nitrogen containing high explosives. The sensor includes a substrate and a blue-photoluminescent metallofluorene copolymer to be carried on said substrate during testing for nitrogen containing high explosives. The copolymer is preferably a blue-photoluminescent metallofluorene copolymer, and preferably is a vinyl bridged silafluorene copolymer. A method for detecting nitrogen containing high explosives involves exposing a copolymer to an analyte, preferably by spraying the copolymer or otherwise coating the substrate after it has been exposed to analyte and then exciting the copolymer to luminesce. The copolymer is observed for fluorescence quenching, which can be through human or electronic observation. The invention also provides for synthesis of a vinyl bridged silafluorene polymer by providing diethynylmetallofluorene and dihydrosilafluorene as precursors and conducting catalytic hydrosilation of the precursors. In a blue emitting organic light emitting diode of the invention, an emitting layer is blue-photoluminescent metallofluorene copolymer.03-10-2011
20100032582FLUORESCENCE DETECTION SYSTEM AND METHOD - A fluorescence detection system comprises a light source configured to produce an excitation light, an optical lens and a fiber bundle. The optical lens is configured to focus the excitation light to a sample to emit fluorescence and to collect the fluorescence. The fiber bundle probe comprises a transmitting fiber configured to transmit the excitation light to the optical lens, and a first receiving fiber configured to deliver the collected fluorescence. The fluorescence detection system further comprises a first detector configured to detect the fluorescence delivered by the receiving fiber to generate a response signal, and a processing unit configured to determine information about the samples by analyzing the response signal. Additionally, a fluorescence detection method is also presented.02-11-2010
20090039286SYSTEM AND METHOD FOR ATTENUATING THE EFFECT OF AMBIENT LIGHT ON AN OPTICAL SENSOR - The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.02-12-2009
20080230715Optical Imaging - An optical imaging apparatus (09-25-2008
20100294950MEASURING APPARATUS, AND LIQUID COLLECTING AND MEASURING SYSTEM HAVING THE SAME - A blood collecting apparatus includes a main flow path and a pressure generator. The pressure generator is provided in an intermediate position of the main flow path to insert a gas as separators at designated predetermined intervals, thereby to take out blood to be measured, as separated in a time series. The blood can be taken out in minute volumes by inserting the separators consisting of the gas while feeding the blood continuously into the main flow path in this way. And consumption of the blood can be held down, and the amount of collected blood can be minimized. Since the operation to insert the separators is excellent in speed, repeated collection in a short time, i.e. frequency of blood collection, can be secured.11-25-2010
20110127444PARTICLE ANALYZING APPARATUS AND PARTICLE IMAGING METHOD - A particle analyzing apparatus, comprising: a flow cell which forms a specimen flow including particles; first and second light sources; an irradiation optical system which applies lights emitted from the first and second light sources so that the lights are applied to the specimen flow; a detector which detects forward scattered light, the forward scattered light being emitted from the first light and scattered by the particle in the specimen flow, and generates a signal according to the detected scattered light; a light blocking member disposed between the flow cell and the detector; a controller which obtains characteristic parameters of the particle based on the signal from the detector; and an imaging device which captures an image of the particle in the specimen flow using the light from the second light source is disclosed. Particle imaging method is also disclosed.06-02-2011
20100320397MOLECULAR DIAGNOSTIC SYSTEM BASED ON EVANESCENT ILLUMINATION AND FLUORESCENCE - An illumination detection system comprises an excitation radiation source and associated radiation processing arrangement, and a focusing arrangement for focusing the excitation radiation from the radiation processing arrangement onto an analysis region of a sample. A radiation collection arrangement collects radiation from the analysis region of the sample resulting from the excitation, and a detector detects the collected radiation. The focused excitation radiation comprises an excitation line which is evanescent in the sample. This combines the advantages of line scanning (reduced analysis time) and evanescent excitation (reduced background signal) and therewith enables increased measurement speed and precision for point of care application.12-23-2010
20110001061FLUORESCENCE OBSERVATION APPARATUS - Clearly observing the state of an examination site is made by sufficiently suppressing the influence of residues. Fluorescence observation apparatus includes: a light source emits excitation light for irradiating the vicinity of an examination site; a fluorescence information acquisition unit acquires information about fluorescence emitted from the vicinity of the examination site through the irradiation with the excitation light from the light source; a residue fluorescence information acquisition unit acquires information about fluorescence emitted from residues selectively dyed with a fluorescent dye, through the irradiation with the excitation light from the light source; and a fluorescence information correction unit generates fluorescence information about the examination site in which the fluorescence from the residues is suppressed, based on the fluorescence information from the vicinity of the examination site, acquired by the fluorescence information acquisition unit, and the fluorescence information from the residues, acquired by the residue fluorescence information acquisition unit.01-06-2011
20110240884OPTICAL TOMOGRAPHIC MEASURING DEVICE - An optical tomographic measuring device that includes: an illuminating component, a plurality of light-receiving components, a storage component, a specifying component, an acquiring component, and a constructing component is provided. The specifying component specifies a position of the measurement plane in the body length direction. The acquiring component acquires, from the storage component, an optical characteristic distribution that corresponds to the position specified by the specifying component. The constructing component constructs a density distribution of fluorescence in the measurement plane, on the basis of intensities of the fluorescence received at the respective light-receiving components and the optical characteristic distribution acquired by the acquiring component.10-06-2011
20110031409Fluorescence detection enhancement using photonic crystal extraction - Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent scattering effects, attributed to leaky photonic crystal eigenmodes (resonance modes). The photonic crystal simultaneously exhibits resonance modes which overlap both the absorption and emission wavelengths of the fluorophore. A significant enhancement in fluorescence intensity from the fluorophores on the photonic crystal surface is demonstrated.02-10-2011
20110042580FLUORESCENCE QUANTIFICATION AND IMAGE ACQUISITION IN HIGHLY TURBID MEDIA - Various embodiments of methods and systems are described herein for the acquisition and quantification of fluorescence or luminescence signals from a region of interest of an object. The quantification of the acquired signals includes performing at least one ratiometric operation to correct these signals for artifacts due to various factors.02-24-2011
20110042582System for Conducting the Identification of Bacteria in Biological Samples - The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.02-24-2011
20120228518FLUORESCENCE CORRELATION SPECTROSCOPY SYSTEM FOR ANALYZING PARTICLES IN A MEDIUM - The present invention relates to a fluorescence correlation spectroscopy system (09-13-2012
20110017923FLUORESCENCE OBSERVATION APPARATUS - A fluorescence observation apparatus according to the present invention includes a light source section that emits excitation light for exciting a first fluorescent substance and a second fluorescent substance, a fluorescence detection section that detects first fluorescent light emitted when the first fluorescent substance is excited and second fluorescent light emitted when the second fluorescent substance is excited, a correction value calculation section that calculates a correction value for canceling a color mixture between the first fluorescent light and the second fluorescent light based on feature values corresponding to characteristics of the first fluorescent substance and the second fluorescent substance, a detected image generation section that generates a first detected image corresponding to a detection result of the first fluorescent light and a second detected image corresponding to a detection result of the second fluorescent light, and an image correction section that corrects a luminance value of the first detected image to a luminance value corresponding to intensity of the first fluorescent light and corrects a luminance value of the second detected image to a luminance value corresponding to intensity of the second fluorescent light.01-27-2011
20110084217SUPERCONTINUUM LASER SOURCE FOR FULL-FIELD CONFOCAL MICROSCOPY, SPIM AND TIRF - A supercontinuum laser is used as the excitation source for full-field confocal, SPIM or TIRF imaging. A supercontinuum laser will allow the use of any wavelength desired for excitation without having to buy additional lasers. The wavelength can be easily selected using an acousto-optical device. Also disclosed is a means for driving an acousto-optical device such that an arbitrary wavelength window can be selected—this allows for the broader wavelength ranges that will give the increased power needed for full-field confocal, SPIM or TIRF imaging.04-14-2011
20090250627ARRANGEMENT FOR PROCESSING SIGNALS AT THE OUTPUT OF A MULTICHANNEL DETECTOR - An arrangement for signal processing at the output of a multichannel detector in the spectrally resolved acquisition of time-variable fluorescence phenomena in a microscope, particularly lifetime measurements, is characterized in that an FPGA (free programmable gate array) is arranged downstream of the output of the multichannel detector.10-08-2009
20100224795TOPICAL COMPOSITION DETECTION - Compositions, devices, methods, and kits are provided for determining the presence of topical compositions on surfaces, such as skin.09-09-2010
20090218513FLUORESCENCE-BASED SCANNING IMAGING DEVICE - A device for analysing a specimen by fluorescence includes a confocal microscope, illumination means capable of emitting a light beam that converges, by means of an objective, on a focal spot, means for successively positioning the focal spot at various points on the specimen during analysis. The confocal microscope includes an objective mounted on a movable rapid-scan carriage driven in a reciprocating linear movement along a traverse direction by a rotating motor by means of a device of the connecting rod type. The specimen is placed on a movable support driven in a longitudinal movement and is able to move along the axis of the objective of the microscope in order to position the specimen relative to the focal spot. The excitation light spectrum is spread over the surface of the specimen in such a way that the excitation light reflected by the specimen and corresponding to the wavelengths close to fluorescence converge on points that are sufficiently distant from a diaphragm positioned in front of a device for measuring the fluorescence.09-03-2009
20090032732MICROSCOPE OBJECTIVE AND FLUORESCENT OBSERVATION APPARATUS THEREWITH - An immersion type microscope objective is configured by, in order from the object side to an image side, a positive lens group Ga including a cemented lens obtained by cementing a plano-convex lens whose plane surface faces the object side to a meniscus lens whose concave surface faces the object side, and a positive single lens, a positive lens group Gb including a cemented lens, a lens group Gc including at least one cemented lens, a lens group Gd having a meniscus lens having a strongly concave surface that faces the image side, and a lens group Ge having a negative lens having a strongly concave surface that faces the object side.02-05-2009
20110248184SENSOR SUBSTRATE SYSTEMS AND METHODS - A sensing apparatus may include a substrate having a first side for a sensing element and a second side for electronics, the substrate may have a at least one via from the first side of the substrate to the second side of the substrate, the at least one via may be hermetically sealed with an optically transmissive material.10-13-2011
20110101239REMOTE SENSING SYSTEM - An airborne the multi-spectral lidar instrument emits and/or detects radiation from target vegetation to assess the condition of the foliage. Time of flight analysis at multiple wavelengths permits three dimensional measurements to discriminate material at different heights, from ground to top of canopy. Radiation at 531 nm (emission and detection, vertically resolved) is used to measure de-epoxidation of the xanthophyll pigments (used for PRI), and also for stimulation of fluorescence. Radiation at 550 and/or 570 or 571 nm (emission and detection, vertically resolved) serves as a reference waveband unaffected by the de-epoxidation (used for PRI). Radiation at 690 and 740 nm (Detection only, no height resolution) or other lines for chlorophyll fluorescence, optionally using Fraunhofer/Oxygen wavelength windows and/or time gating to improve SNR. Wavelengths of 860 and 1200 nm, or similar (emission and detection, vertically resolved) are applied to measurement of water absorption and estimation of NDWI. Results are combined with known available radiation to estimate primary productivity.05-05-2011
20110068278FLUORESCENCE OBSERVATION APPARATUS - To accurately obtain fluorescence intensity in a variable passband. Provided is a fluorescence observation apparatus including an excitation light source that emits excitation light; a Fabry-Perot resonator including a variable passband in which the wavelength of light that passes therethrough changes with changes in distance between the surfaces of optical members opposing each other with a distance therebetween, a fixed passband in which the wavelength of light that passes therethrough does not change irrespective of changes in the distance between the surfaces, and a transition band therebetween; an excitation-light cut filter that blocks passage of the excitation light; a band cut filter having a cut-off band including the transition band and not including the wavelength of the excitation light; and a photodetector that detects fluorescence that has passed through the Fabry-Perot resonator, the excitation-light cut filter, and the band cut filter.03-24-2011
20110062348DEVICE AND METHOD FOR THE EVANESCENT ILLUMINATION OF A SAMPLE - A device for the evanescent illumination of a sample, including an optical illumination element with an optical corrective element and an objective arranged downstream from the corrective element, to evanescently illuminate the sample with a supplied ray beam containing optical radiation with at least two different wavelengths. The corrective optical element has a transverse chromatic aberration which, during the illumination, leads to the optical radiation penetrating the pupil of the objective at different heights relative to the optical axis varying according to the wavelength. The corrective optical element is selected in such a way that the wavelength-related difference of the penetration depths of the radiation into the sample is reduced during the evanescent illumination.03-17-2011
20110049387HANDLING OF CONTAINERS WITH DIRT DETECTION - A method of operating a device for the handling of containers, wherein the containers are conveyed at least locally through the device and are handled by the device in at least one pre-set manner, and wherein at least one flowable medium is used to operate the device. According to various aspects, pre-set areas of the device are irradiated by means of a radiation device in order to make at least one medium detectable in an area of the device in which the medium is present in a non-functional manner.03-03-2011
20100294947FLUORESCENT MEASUREMENT DEVICE FOR LIVING BODY AND EXCITING LIGHT-IRRADIATING DEVICE FOR FLUORESCENT MEASUREMENT - Disclosed herein is a fluorescence measurement device for a living body configured to be able to reduce wavelength components that will become leak light and to easily switch a wavelength and an irradiation direction. The fluorescence measurement device for a living body comprises: a sample holder on which a living body sample is to be placed; an exciting light-irradiating device having a plurality of exciting light sources arranged at mutually different positions, each of which is composed of a laser diode or a light-emitting diode and is provided with a filter having an optical property to eliminate, from a spectrum of the exciting light source, disturbing wavelength components overlapping with wavelength components of fluorescence to be detected; an electrical switch for switching lighting of the exciting light sources; a detector for picking up an image produced by fluorescence emitted from the sample placed on the sample holder; and an image display device for displaying the image picked up by the detector.11-25-2010
20100294949SCANNING MICROSCOPE DEVICE - Spectrum detection is performed at a high S/N ratio, high sensitivity, and high speed. Provided is a scanning microscope device that includes a light source that irradiates a sample with laser light; an X-Y galvanometer mirror that scans the laser light from the light source on the sample; an objective lens that irradiates the sample with the laser light scanned by the X-Y galvanometer mirror and collects fluorescence generated at an irradiated position of the laser light; a non-descan-detection excitation DM that is disposed between the X-Y galvanometer mirror and the objective lens and separates the laser light and the fluorescence from each other; an fiber for epi-fluorescence that receives the separated fluorescence through an entrance end thereof, guides the fluorescence, and emits the fluorescence from an exit end thereof that is formed in a substantially linear shape; a diffraction grating that disperses the fluorescence emitted from the exit end of the fiber for epi-fluorescence in a direction orthogonal to the longitudinal direction of the exit end; and a multi-anode PMT having a plurality of cells arrayed in the dispersing direction of the fluorescence dispersed by the diffraction grating.11-25-2010
20100252748Multi-Purpose Measurement System - The invention relates to an apparatus for optically analysing samples contained in sample sites of a sample holder, the apparatus comprising a first light source and at least one second light source, a monochromator having an input to which first light source is optically connected or connectable and an output for monochromatized light, light guiding means for guiding light originating from the first and from the at least one second light sources to the sample sites, and a detector for detecting light from the sample sites. According to the invention, the apparatus further comprises a light relay comprising a first input optically connected to the output of the monochromator, at least one second input optically connected or connectable to a second light source such that the light from the second light source by-passes the monochromator, and a first output for guiding light from selected input of the light relay to the sample sites. By means of the invention, a versatile sample analyser can be achieved in a cost-effective manner.10-07-2010
20100032583Optical Chemical Sensor Feedback Control System - An optical chemical sensor feedback control system is provided comprised of a luminescent sensing film, an optical processor adjacent the sensing film capable of sinusoidally photoexciting the luminescent sensing film and detecting the luminescent emission resulting therefrom, and a computer control means executing a computer program, in communication with the optical processor. The computer control means is operable to control the magnitude of the photoexcitation of the luminescent sensing film, wherein the computer control means receives data regarding the luminescent emission resulting therefrom, analyzes same, and determines the magnitude and phase shift of the luminescence relative to the photoexcitation. Further, the system herein is operable to determine the status of the sensing film, and adjust the magnitude of photoexcitation thereof based on same. In addition, the system, via the optical processor positioning means, is operable to adjust the physical position of the optical processor and/or light source in relation to the sensing film, based on data received from the computer control means.02-11-2010
20090001284Biosensor with One-Dimensional Sub-Diffraction-Limited Apertures Composed of a Grid and a Polarizer - A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (01-01-2009
20080315118FLUORESCENCE MEASUREMENT PROBE - A fluorescence measurement probe capable of stably receiving a maximum received light amount of a fluorescent light generated from a specimen onto which an excitation light is radiated. The fluorescence measurement probe is applied to a fluorescence measurement system provided with an optical system. A light source emits an excitation light. A detector receives the fluorescent light. A solid light guide path serves as an optical path of the excitation light as well as the fluorescent light. A lens is disposed between an edge surface of the solid light guide path and the specimen. When a radiation angle of the excitation light is set to 2θ at a position where the excitation light is collected by the lens which collects the fluorescent light. A excitation light beam NA expressed by sin θ is set to 0.14 or more and 0.31 or less.12-25-2008
20100301229OPTICAL ASSAY SYSTEM FOR INTRAOPERATIVE ASSESSMENT OF TUMOR MARGINS - The subject matter described herein includes an optical assay system for intraoperative assessment of tumor margins. According to one aspect, the subject matter described herein includes a biological sample containment and illumination apparatus for holding a biological sample for illumination by a plurality of electromagnetic radiation probes. The biological sample containment and illumination apparatus includes a plurality of frame members positioned with respect to each other to form an interior space for receiving a biological sample. At least one of the plurality of frame members includes a plurality of probe receiving locations for receiving a plurality of electromagnetic radiation probes. The probe receiving locations position the probes with respect to the biological sample to allow illumination of plural locations of the biological sample by the probes.12-02-2010
20110089338MULTIPHOTON FLUORESCENCE FILTERS - An optical filter is provided which includes a plurality of hard coating layers of alternating high and low refractive index provided on a substrate and has an associated first transmission band. The filter also includes at least one additional plurality of hard coating layers including high and low refractive index layers and Herpin equivalent layers sandwiched therebetween. The additional plurality of layers has an associated second transmission band that substantially coincides with the first transmission band, but provides additional blocking at wavelengths outside the first transmission band. Relatively wide transmission bands and high blocking over an extended range of wavelengths can be achieved such that the filter is suitable for use in multiphoton fluorescence systems.04-21-2011
20110168913PHASE LOCKED SIDEBAND BEAMS BY BIAS MODULATION OF AN EXTERNAL CAVITY LASER DIODE HAVING A GRATING - A device and a method enabling the enhancing of the modulation efficiency of lasers by matching the modulation frequency and the FSR of the laser. This is optionally achieved by eliminating the internal cavity of a laser diode (07-14-2011
20120145923FLUORESCENCE MICROSCOPE - A fluorescence microscope includes: a light source that emits excitation light for exciting a sample; an optical detector that detects fluorescence emitted from the sample excited by the excitation light; a first wavelength selection filter arranged in an optical path leading from the light source to the sample to reflect at least an S-polarized component of the excitation light and transmit the fluorescence; and a second wavelength selection filter arranged in an optical path between the optical detector and the first wavelength selection filter to reflect at least the S-polarized component of the excitation light and transmit the fluorescence. In the fluorescence microscope, light entering and transmitted through the first wavelength selection filter as P-polarized light enters the second wavelength selection filter as S-polarized light.06-14-2012
20120145922CHLOROPHYLL FLUOROMETER AND MEASURING SYSTEM FOR CHLOROPHYLL CONCENTRATION EMPLOYING THE SAME - An exemplary measuring system for chlorophyll concentration of the present invention includes a chlorophyll fluorometer. The chlorophyll fluorometer includes a temperature sensor and an outer illuminator sensor. The outer illuminator sensor is electrically connected to the temperature sensor.06-14-2012
20110133099SILICON CONCENTRATION MEASURING INSTRUMENT - The present invention is an instrument that detects a trace amount of silicon contained in a sample solution with simple means and measures a silicon concentration in the sample solution, and adapted to include: an excitation light irradiation part that irradiates the sample solution with excitation light for silicon; a light detection part that detects fluorescence and/or scattering light emitted from silicon in the sample solution irradiated with the excitation light; and a calculation part that calculates the silicon concentration in the sample solution from intensities or an intensity of the fluorescence and/or the scattering light.06-09-2011
20110147613DEVICE AND METHOD FOR ENHANCED ANALYSIS OF PARTICLE SAMPLE - The present disclosure relates to a device for analyzing a dissolved particle sample, said device comprising a microscope system, said microscope system comprising support supporting said sample, an illumination source operably emitting a luminous energizing beam, an optic member focusing said luminous energizing beam into a focal point on said sample, and a spatial filter operably defining an analyzed space around the focal point, and said microscope system comprising an interface operably enhancing said luminous energizing beam, said enhancement interface including a strictly positive focal length and a refractive index greater than the refractive index of said sample, at least a portion of said enhancement interface being disposed on the path of said luminous energizing beam downstream from said support and upstream from said focal point, and at least a portion of said enhancement interface not being rigidly connected to said support. The present disclosure also relates to a method for analyzing a dissolved particle sample by such an analyzing device.06-23-2011
20100294948OPTICAL WAVELENGTH DEMULTIPLEXING DETECTOR FOR FLUORESCENCE ANALYSIS AND FLUORESCENCE DETECTION SYSTEM - An optical wavelength demultiplexing detector for fluorescence analysis that is compact, has a small number of components, and is easy to assemble. An excitation light received via a first optical transmission path is outputted to a second optical transmission path, and a fluorescence arising from the excitation light outputted from the second optical transmission path is received via the second optical transmission path and detected. The excitation light having propagated through the first optical transmission path and the fluorescence having propagated through the second optical transmission path are received by the same surface of a first lens. An optical wavelength selection member comprised of a dielectric multilayer film receives the excitation light and the fluorescence passed through the first lens, and reflects the excitation light and passes the fluorescence. A photoelectric conversion element directly receives the fluorescence passed through the first optical wavelength selection member.11-25-2010
20100224793DETECTION SYSTEM AND PROBE THEREFOR - There is provided a detection system capable of simultaneously detecting a plurality of fluorescences or phosphorescences having different dominant wavelengths generated from a minute region and a probe therefor. A fluorescence detection system includes a probe having a lens and optical fibers and arranged on one end thereof. The probe receives excitation light with a dominant wavelength and excitation light with a dominant wavelength at one end of the lens and converges the excitation lights at the solution containing Cy3 and Cy5 in a channel inside a microchemical chip and the probe receives fluorescence with a dominant wavelength and fluorescence with a dominant wavelength at the other end of the lens and converges the fluorescences at the tips of the optical fibers.09-09-2010
20120037817SYSTEM FOR ANALYZING A SAMPLE OR A SAMPLE COMPONENT AND METHOD FOR MAKING AND USING SAME - A system and associated method are disclosed for analyzing a sample or sample component including species capable of producing fluorescent light when excited by a light source, where the light source comprises an excimer light source having a high voltage power supply with voltage and current regulation circuitry.02-16-2012
20120037816MEASURING DEVICE FOR DETERMINATION OF AT LEAST ONE PARAMETER OF A BLOOD SAMPLE - Measuring devices are disclosed for determination of at least one parameter of a blood sample. The measuring device includes a flow-through measuring cell, in which is disposed luminescence-optical sensor elements, which can be brought into contact with the blood sample, and at least one light source for excitation of the luminescence-optical sensor element and at least one photodetector for receiving the luminescence radiation emitted by the luminescence-optical sensor element. The light source and the photodetector are located on opposite sides of the flow-through measuring cell. The sensor elements are placed on an excitation side of the flow-through measuring cell, which faces the light source, and the light source emits excitation radiation of wavelength less than 600 nm, while the luminescence radiation of the sensor elements lies in a wavelength range greater than 600 nm, thus exposing the excitation radiation to stronger absorption by the blood sample than the luminescence radiation.02-16-2012
20120043476COMBINED LENS AND REFLECTOR, AND AN OPTICAL APPARATUS USING THE SAME - A lens and reflector unit for optical measurements includes first and second convex surface sections of the lens and reflector unit. Both have their respective central normal lines. A first flat surface section has a normal direction that divides the angle between the central normal lines into equal halves. A third convex surface section has a third central normal line, and the fourth convex surface section has a fourth central normal line. A second flat surface section has a normal direction that divides the angle between the third and fourth central normal lines into to equal halves.02-23-2012
20090032733Apparatus for Measuring Fluorescent Material In A Liquid - An apparatus (02-05-2009
20100038558MODE-LOCKED LASER DEVICE, PULSED LASER LIGHT SOURCE DEVICE, MICROSCOPE DEVICE - There is provided a mode-locked laser including: a resonator having a pair of resonance mirrors; a solid-state laser medium, disposed in the resonator and outputting oscillating light due to excitation light being incident thereon; an excitation unit that causes the excitation light to be incident on the solid-state laser medium; a mode-locked element, disposed in the resonator for inducing mode locking; and a temperature adjusting unit that adjusts the temperature of the pair of resonance mirrors such that oscillating light of a specific frequency is output from the resonator.02-18-2010
20120001089BODY MODULE FOR AN OPTICAL MEASUREMENT INSTRUMENT - A body module of an optical measurement instrument includes: a reception device (01-05-2012
20110155925REFINED OIL DEGRADATION LEVEL MEASURING INSTRUMENT AND REFINED OIL DEGRADATION LEVEL MEASURING METHOD - In situ monitoring of a degradation level of refined oil during use is provided. An excitation light irradiation part varies intensity of excitation light to irradiate the excitation light onto the refined oil with a resulting fluorescence. A fluorescence intensity detection part detects the intensity of fluorescence generated by the irradiation of the excitation light, and a time lag characteristic calculation part calculates a time lag characteristic of a fluorescence intensity variation with respect to the intensity variation of the excitation light. A degradation index value acquisition part provides to a predetermined correlation between a degradation index value indicating a degradation level of the refined oil and the time lag characteristic is used to acquire a degradation index value from a time lag characteristic calculated in the time lag characteristic calculation part t determine the current degradation status of the oil.06-30-2011
20120007000Multi-color fluorescence enhancement from a photonic crystal surface - A photonic crystal substrate exhibiting resonant enhancement of multiple fluorophores has been demonstrated. The device, which can be fabricated uniformly from plastic materials over a ˜3×5 in01-12-2012
20100038559APPARATUS AND METHOD FOR FLUORESCENCE MEASUREMENTS USING SPATIALLY STRUCTURED ILLUMINATION - An apparatus is disclosed for depth selected fluorescence measurements of a sample. The apparatus may include a carrier for at least one sample substance, the carrier having at least one transparent, planar bottom wall having an upper surface; projection optics having a first optical axis, to expose the at least one sample substance through the bottom wall to a spatially structured pattern of excitation radiation, the projection optics including a first object plane and an image plane that are subject to a Scheimpflug condition, the image plane being substantially coplanar with the upper surface of the bottom wall of the carrier; an image capture module having a second optical axis, a second object plane substantially coplanar with the image plane, and a detection beam path, to receive a data image from the sample; a signal processor to transform the data image to provide depth selected fluorescence measurement for the at least one sample substance; and an arrangement whereby the first optical axis is inclined relative to the second optical axis so that the projection optics has an angle of inclination relative to the image plane, the angle of inclination being selected such that a component of excitation radiation incident upon, but not absorbed by, the at least one sample substance is scattered or reflected to substantially reduce excitation radiation from reaching the detection beam path. A corresponding method is disclosed.02-18-2010
200902427983D Biplane Microscopy - A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.10-01-2009
20110049388PLANAR OPTICAL WAVEGUIDE WITH CORE OF LOW-INDEX-OF-REFRACTION INTERROGATION MEDIUM - An apparatus for illuminating a sample includes a planar waveguide. The planar waveguide includes a first substrate, including a first outer surface and a first inner surface, and a second substrate, including a second outer surface and a second inner surface. The first and second inner surfaces of the first and second substrates, respectively, are spaced apart from each other and partly define a volume for confining the sample therein. The apparatus also includes a light source for providing light directed toward the planar waveguide, such that the light is optically coupled to and contained within the planar waveguide between the outer surfaces of the first and second substrates, while illuminating at least a portion of the sample confined within the volume.03-03-2011
20110049386FLUORESCENCE IMAGE PRODUCING METHOD, FLUORESCENCE IMAGE PRODUCING APPARATUS, AND FLUORESCENCE IMAGE PRODUCING PROGRAM - Method and apparatus for producing an image associated with a biological sample is provided. The biological sample is focused on the biological sample based on fluorescence of a first fluorescent material and the image is captured based on fluorescence of the second fluorescent material. A computer readable memory device storing instructions to cause a data processing unit is also provided.03-03-2011
20110049385Sample Measurement System - The invention relates to an apparatus and method for optically analysing samples contained in sample sites of a sample holder by means of fluorescence. The apparatus comprises a first light source comprising a plurality of individual light sources having narrow wavelength bands, means for further limiting wavelength bands of the light emitted by the individual light sources, means for guiding the reduced-wavelength light to the sample sites of the sample holder, and a detector for detecting light from the sample sites. According to the invention said means for further reducing the wavelength bands emitted by the individual light sources comprise a wavelength-tunable single monochromator. The invention allows manufacturing of a microplate reader having the capability for fluorescence measurements at a continuous wavelength range, while maintaining the cost of the device at a reasonable level.03-03-2011
20110049384Imaging Systems Featuring Waveguiding Compensation - In certain embodiments, the invention relates to systems and methods for altering an image to compensate for variation in one or more physical and/or supervenient properties (e.g., optical absorption and/or scattering) in heterogeneous, diffuse tissue, thereby attenuating the effects of tissue waveguiding. The methods enable the proper identification of emission image regions that evidence waveguiding of electromagnetic radiation, and enables compensation of emission images for such waveguiding. The methods preserve the depth localization accuracy of the FMT approach and improve optical reconstruction in the targeted areas while eliminating spurious components of fluorescence from the acquired data set. Calibration methods for probe concentration mapping are also presented.03-03-2011
20120305801FLUORESCENCE DETECTING OPTICAL SYSTEM AND MULTI-CHANNEL FLUORESCENCE DETECTION APPARATUS HAVING THE SAME - A fluorescence detecting optical system, and a multi-channel fluorescence detection apparatus comprising same, comprising a light source that emits excitation light, a polarizer that transmits light having a predetermined polarization component, a polarizing beam splitter that transmits light having a predetermined polarization component and reflects light having a different polarization component than the predetermined polarization component, and a quarter-wave plate converting linearly polarized to circularly polarized light or vice versa.12-06-2012
20120153185MICROCHIP AND PARTICULATE FRACTIONAL COLLECTION APPARATUS - A microchip includes a sample liquid feed channel permitting a sample liquid containing particulates to flow through, at least one pair of sheath liquid feed channels configured to merge to the sample liquid feed channel from both sides thereof for permitting a sheath liquid to flow through surrounding the sample liquid, a merging channel connected to the sample liquid feed channel and the one pair of the sheath liquid feed channels for permitting the sample liquid and the sheath liquid to merge and flow through the merging channel, a vacuum suction unit for drawing into the particulate subject to collection, connected to the merging channel, and at least one pair of discharge channels formed on both sides of the vacuum suction unit for permitting to flow through from the merging channel.06-21-2012
20120153184LUMINESCENT PHOSPHOR-CONTAINING MATERIALS, AND METHODS FOR THEIR PRODUCTION AND USE IN AUTHENTICATING ARTICLES - Embodiments of luminescent phosphor-containing materials include a medium and particles of a phosphor compound dispersed in the medium. The phosphor compound includes a host lattice comprising at least one alkaline earth element, manganese, and europium (e.g., divalent manganese and divalent europium). Embodiments of methods for producing such a phosphor-containing material include preparing a phosphor compound that includes the phosphor compound particles, and dispersing the particles in the medium to produce the phosphor-containing material. The material may then be incorporated into an article. Embodiments of a method for identifying a phosphor-containing material incorporated with an article include exposing a portion of the article to exciting radiation (e.g., light produced by a blue diode), and determining whether a detected emission produced as a result of the exciting radiation indicates a manganese emission following a europium absorption for at least a first time period after termination of the exposing step.06-21-2012
20100096560OPTICAL MEASURING DEVICE - An optical measuring device includes: a light applying section configured to apply laser light to a sample flowing in a channel; and a fluorescence detecting section configured to detect fluorescence generated from the sample irradiated with the laser light; the fluorescence detecting section including a multichannel photomultiplier tube having a plurality of detection channels capable of simultaneously detecting a plurality of light beams, a light separator configured to separate the fluorescence according to wavelengths to provide the plurality of light beams, the light separator being provided by a transmission grating or a prism, and a telecentric condenser lens configured to receive the plurality of light beams from the light separator and direct the plurality of light beams toward the plurality of detection channels of the multichannel photomultiplier tube so that the optical axes of the plurality of light beams are parallel to each other.04-22-2010
20120104279Fluorescence Light Scanning Microscope Having a Birefringent Chromatic Beam Shaping Device - A fluorescence light scanning microscope (05-03-2012
20120112093SYSTEM AND METHOD FOR MEASURING DEPOLARIZATION - An apparatus for determining the depolarization efficiency of a environment includes a transmitter, a receiver, and signal processing circuitry. A reference object is located within the environment at a reference distance. The transmitter includes a radiation source providing incident radiation that has an initial polarization as it enters the environment. The receiver receives returned radiation from the reference, which may be diffuse reflection or photoluminescence. The signal processing circuitry calculates the depolarization efficiency of the environment from the initial polarization, luminescence or final polarization, and the reference distance. A method of determining depolarization efficiency includes directing incident radiation having initial polarization through an environment onto a reference, detecting returned radiation from the reference, and calculating the depolarization efficiency using the initial polarization and the luminescence or final polarization.05-10-2012
20120153186Modular Computed and Direct Radiography Assembly And Method - The present invention is directed to a modular scanning apparatus that can be advantageously used in both computed radiology devices and fixed scanning direct radiology devices. The scanning assembly advantageously utilizes a light collecting and measuring assembly having highly reflective surfaces in conjunction with a novel optical assembly within a light box type enclosure to enable a modular scanning and reading assembly that is compact, robust and also scaleable. The present invention further discloses novel computed radiography and direct radiography devices that utilize the modular scanning assembly to provide radiology devices that are highly robust and efficient and yet also simple to build, maintain, service and repair.06-21-2012
20110089339LASER SCANNING MICROSCOPE - Provided is a laser scanning microscope that allows stable examination by eliminating the influence of ambient light while inhibiting damage to a specimen and fading of fluorescence. Employed is a laser scanning microscope 04-21-2011
20120161033MICROORGANISM DETECTION APPARATUS - A microorganism detection apparatus including a light source unit to irradiate light, a mirror chamber including a light inlet port and a light outlet port, through which the light is introduced and discharged, respectively an inlet port and an outlet port, through which particles are introduced and discharged, respectively, so that light emitted from the particles (emitted particle light) is generated by the light, and an opening, through which the emitted particle light is discharged outside. The mirror chamber has an oval longitudinal section, and is provided at an inside thereof with a mirror. A condensing optical system is disposed in front of the opening outside the opening to condense the emitted particle light discharged through the opening. Condensing efficiency of the fluorescent light condensing optical system is maximized.06-28-2012
20100288942OPTICAL ILLUMINATION APPARATUS FOR ILLUMINATING A SAMPLE WITH A LINE BEAM - An optical system for illuminating a sample with a line beam comprises a light source (11-18-2010
20100224794MULTIPHOTON-EXCITED MEASURING DEVICE - A multiphoton-excited measuring device measuring a sample with the use of a multiphoton absorption phenomenon by optical pulses having high intensity, comprising a short pulse light source 09-09-2010
20110180725FLUOROMETRIC APPARATUS, FLUOROMETRIC METHOD, CONTAINER FOR FLUOROMETRY, AND METHOD OF MANUFACTURING CONTAINER FOR FLUOROMETRY - A fluorometric apparatus capable of configuring to have a small size and operability requiring a simple and easy operation of centrifuging a specimen in a container a rotation center of which is detachably supported by a rotation axis (not shown), exciting the specimen by means of an N07-28-2011
20120313007CLIP-ON TARGET DESIGNATION SENSOR TO NIGHT VISION GOGGLES - A target engagement system includes a night vision goggle system operating within a predetermined wavelength band, and a laser module projecting light onto a target, where the light operates at a wavelength that is outside of the predetermined wavelength band. Also included is a receive system for receiving the light reflected from the target and converting the light into a wavelength within the predetermined wavelength band. In this manner, the receive system provides the converted light to the night vision goggle system, and the night vision goggle system amplifies the converted light for viewing by a user. The receive system includes a clip-on device for removably attaching the receive system between the target and the night vision goggle system. The receive system includes an up-converting phosphor layer for up-converting the received light into a wavelength detectable by the night vision goggle system.12-13-2012
20120248333Device For Fluorescence Diagnosis - A diagnosis device having an illumination system configured to produce white light along an illumination path, an observation system for observing the target region in a white-light and fluorescence mode, the observation system having an observation path having at least one first image sensor for receiving a white-light image and at least one second image sensor for receiving a fluorescence image, an observation spectral filter in the observation path are configured such that light in the spectral range of the fluorescence can be fed to the second image sensor while light in the spectral ranges outside of the fluorescence is blocked. An illumination spectral filter is arranged in the illumination path and having a characteristic of the observation spectral filter such that the target region is illuminated with the whole spectral range of the white light with the exception of the spectral range of the fluorescence to be observed.10-04-2012
20120211669SCINTILLATOR PANEL AND PRODUCTION METHOD THEREOF, FLAT PANEL DETECTOR AND PRODUCTION METHOD THEREOF - Disclosed is a scintillator panel provided with on a support a phosphor layer comprising columnar crystals and a protective layer sequentially in this order, wherein degraded areas on lateral surfaces of columnar crystals at an end of the phosphor layer and produced by a cutting treatment account for not less than 0% and not more than 40% of an area of all of the side surfaces of the columnar (irystals A production method of the scintillator panel is also disclosed.08-23-2012
20100308234Improved Measurement System and Method - The invention concerns a measurement system and method for optical spectroscopic measurement of samples. The system comprises an illumination source for forming a primary light beam, a first tunable monochromator for spectrally filtering the primary light beam, a sample-receiving zone to which the spectrally filtered primary beam is directed for producing a secondary light beam affected by a sample in the sample receiving zone, and a second tunable monochromator for spectrally filtering the secondary light beam, and a detector for measuring the intensity of the spectrally filtered secondary beam. In particular, the system is adapted to scan a predefined wavelength range using one of the monochromators and to tune the other monochromator sequentially to one of at least two predefined separate wavelengths in order to eliminate the effect of undesired diffraction orders of the second monochromator on the measurement. The invention allows for eliminating the use of optical diffraction order filters on the emission side of a fluorescence measurement system.12-09-2010
20100308233Optoelectronic Sensor System - The underlying objective of the invention is to create an optoelectronic sensor system which illuminates the specimen homogenously and only allows produced fluorescent light to reach the photoactive layer.12-09-2010
20090101836FLUORESCENCE SENSOR AND METHOD FOR PRODUCING THIN METAL FILM WITH APERTURES TO BE USED BY THE FLUORESCENCE SENSOR - An excitation light beam is emitted from a light source. The excitation light beam propagates through a substrate and enters an interface between the substrate and a thin metal film having fine apertures with diameters less than or equal to the wavelength of the excitation light beam, provided on the surface of the substrate opposite that on which the excitation light beam is incident. Near field light is generated at the fine apertures. Fluorescent labels, included in a sample which is supplied to contact the thin metal film, are excited by the near field light and/or surface plasmon on the thin metal film induced by the near field light. The fluorescence emitted from the fluorescent labels is detected by a photodetector.04-23-2009
20120313008FLUORESCENT DETECTOR - A fluorescence detector for detecting fluorescence emitted from at least one sample contained in at least one sample unit, the fluorescence detector including at least one irradiating module which irradiates an excitation light to the sample; a fluorescence selecting unit which selectively transmits fluorescence emitted from the sample; a light-receiving unit which detects the fluorescence; and a telecentric lens positioned between the fluorescence selecting unit and the light-receiving unit, wherein each of the at least one irradiating module comprises: at least one light source which emits a light; an excitation light selecting unit which converts the light emitted from the at least one light source into the excitation light; and a beamsplitter which controls the excitation light to travel to the sample, and transmits the fluorescence emitted from the sample.12-13-2012
20100270478DETECTION SYSTEM AND METHOD - A detection system, comprising: a radiation source (10-28-2010
20090020709IMAGE PROCESSING SYSTEM, IMAGE PROCESSING METHOD AND COMPUTER READABLE MEDIUM - Provided is an image processing system including: a specific wavelength image obtaining section that obtains a specific wavelength image being an image of light from an object existing inside a substance, the light belonging to a specific wavelength region; a depth calculator that calculates a depth of the object from a surface of the substance, using a plurality of specific wavelength images corresponding to different specific wavelength regions from each other; and an object image generator that generates an image of the object according to the depth of the object calculated by the depth calculator.01-22-2009
20110121201OPTICAL SYSTEM AND METHOD FOR INSPECTING FLUORESCENTLY LABELED BIOLOGICAL SPECIMENS - A system for imaging a fluorescently labeled sample is presented, The system comprises a capsule, which is a closable structure made of a material isolating the inside of the capsule from its surrounding environment, and which has a support stage for receiving the sample and carrying it thereinside during the imaging; and an optical device at least partly accommodated inside the capsule and operable to illuminate the sample with incident radiation to excite a fluorescent response of the sample, detect the fluorescent response, and generate data indicative thereof.05-26-2011
20110121200FLUORESCENCE OBSERVATION APPARATUS - A quantitative fluorescence image and appropriate brightness is acquired and observed. Provided is a fluorescence observation apparatus including: an illumination section that includes a light source for irradiating an observation target region with illumination light and excitation light; a fluorescence image acquisition section that acquires a fluorescence image from fluorescence produced in the observation target region; a white-light image acquisition section that acquires a reference image from return light returning from the observation target region; an exposure-time adjustment unit that adjusts the exposure time based on the luminance value of the reference image; a diaphragm control section and a semiconductor laser control section that control the intensity of the illumination light and that of the excitation light based on the exposure time; a first normalization section that normalizes the luminance of the reference image and the fluorescence image by the exposure time; a second normalization section that normalizes the luminance of the reference image and the fluorescence image by the light intensity; and 05-26-2011
20110121199IMAGING APPARATUS FOR LOW-LIGHT SAMPLE - An imaging apparatus for low-light sample comprises: an image-forming optical system which includes an objective lens and an image-forming lens and forms the sample image of an sample having a point light source, where the point light source emits weak light including fluorescence; an illumination optical system which radiates light from an illumination light source to the sample to make the sample emit fluorescence; and an image capturing means which includes a plurality of pixels and captures the image corresponding to the sample image. The illumination optical system radiates light from the illumination light source to the sample with the light not traveling via the objective lens, the image-forming optical system is approximately telecentric and is provided with a filter which is arranged between the objective lens and the image forming lens and wavelength-selectively extracts fluorescence from the sample, and the image-forming optical system is formed in such a way that the image-forming optical system collects weak light from the point light source to form airy disks the sizes of which are is approximately the same as or smaller than the sizes of the pixels.05-26-2011
20110121198LASER SCANNING MICROSCOPE - Provided is a laser scanning microscope with which it is possible to reduce the time required for scanning and to detect light from a sample with high sensitivity. Provided is a laser scanning microscope 05-26-2011
20080296511Apparatus for fluorescence observation - An apparatus for fluorescence observation includes an excitation filter which transmits only exciting light of an specific wavelength among illumination light, and an absorption filter which blocks the exciting light and transmits only fluorescence generated from a specimen when the exciting light is irradiated to the specimen. Here, an interval of a half-value wavelength at a long-wavelength side of the excitation filter and a half-value wavelength at a short-wavelength side of the absorption filter is in a width between 1 nm to 6 nm, and change of the half-value wavelength of the excitation filter and the absorption filter when humidity changes from 10% to 95%, is 0.5 nm or less.12-04-2008
20100327183Apparatus And Method For System Identification - Methods and apparatus for system identification operate by computing phase and amplitude using linear filters. By digitally processing the linearly filtered signals or data, the phase and amplitude based on measurements of the input and output of a system, are determined.12-30-2010
20110036993LASER SCANNING MICROSCOPE - The present invention relates to a laser scanning microscope capable of acquiring suitable fluorescent images. A fluorescence detection unit 02-17-2011
20110036992LIGHT DETECTION DEVICE - Disclosed herein is a light detection device including, at least, a substrate provided with a plurality of detection regions where to perform detection of fluorescent light emitted from the inside of a sample upon irradiation of the sample with light, a light irradiation section operable to perform the irradiation with light, an optical control section configured to irradiate the detection regions with the light radiated from the light irradiation section, and a light detection section operable to detect the fluorescent light.02-17-2011
20110215257Separation Device - A separation device for preparing biological samples for cytological, cytohistological and histological analysis includes a series of communicating chambers, means for moving a fluid through the chambers and one or more separating units for separating material contained in the fluid, wherein the separator units are arranged along the path of the fluid between the chambers.09-08-2011
20110226961QUANTUM EFFICIENCY MEASUREMENT METHOD, QUANTUM EFFICIENCY MEASUREMENT APPARATUS, AND INTEGRATOR - A quantum efficiency measurement method includes the steps of: disposing a sample at a predetermined position in an integrator having an integrating space; applying excitation light to the sample and measuring a spectrum in the integrating space as a first spectrum through a second window; configuring an excitation light incident portion so that excitation light after having passed through the sample is not reflected in the integrating space; applying the excitation light to the sample and measuring a spectrum in the integrating space as a second spectrum through the second window; and calculating a quantum efficiency of the sample based on a component constituting a part of the first spectrum and corresponding to a wavelength range of the excitation light, and a component constituting a part of the second spectrum and corresponding to a wavelength range of light generated by the sample from the received excitation light.09-22-2011
20120319006FLUOROSCOPY SYSTEM - Provided is a fluoroscopy system includes a light source device that emits white light and excitation light for irradiation of a subject; a white-light-image generating section that generates a white-light image by capturing the white light reflected from the subject; a fluorescence-image generating section that generates a fluorescence image by capturing fluorescence from the subject irradiated with the excitation light; an intensity-distribution generating section that generates a fluorescence intensity distribution of pixels of the fluorescence image; a peak-detecting section that detects a fluorescence-intensity peak in the fluorescence intensity distribution; a peak-count comparing section that calculates a count of the peak; an image-combining section that generates a combined image by superimposing a display representing a region including a pixel having the fluorescence intensity at the peak on the white-light image or the fluorescence image based on the peak count; and a monitor that displays the combined image.12-20-2012
20120319005Surface Electromagnetic Waves in Photonic Band Gap Multilayers - A device and associated methods for using surface electromagnetic waves (SEWs) generated at the surface of photonic band gap multilayers (PBGMs) in place of surface plasmons (SPs) in metal films. One device is a photonic circuit comprising a multilayer apparatus to generate surface electromagnetic waves, wherein the surface electromagnetic waves comprise the signal medium within the circuit. The multilayer apparatus comprises a prism with a dielectric multilayer deposited on one side.12-20-2012
20120080611DEVICE AND METHOD FOR MEASURING SCATTERING OF RADIATION - A photometric device for investigating a sample, comprises an array of radiation sources that are spaced apart from one another, and which are operable to generate radiation that differs from that generated by the other radiation sources in the array. The device includes a lens arrangement for focusing the radiation at a region of space where a sample may be located for example by means of a sample holder, and at least one detector for receiving radiation from the region of space. Preferably, a number of detectors are employed that are spaced apart from one another, and especially about an axis of the device, so that one radiation detector can detect radiation transmitted by the sample and the other detectors can detect radiation scattered by it. The radiation sources may be time division multiplexed so that in each time slot the detectors receive radiation originating from each radiation source. In an alternative embodiment, the radiation from the region of space may be transmitted to the sample via a beam homogeniser, for example an optical waveguide in the form of an optical fibre, which may be used to reduce or remove speckle where laser diodes are employed as the radiation sources. The device may be used to determine the particle size distribution of particles in a sample by a method employing Bayesian inference.04-05-2012
20120080612CANTILEVER-BASED MEMS OPTICAL SCANNING APPARATUS, SYSTEM AND METHOD - The present invention relates to an optical scanning apparatus and an optical scanning system The optical system includes an optical engine connected to an optical scanning probe The optical scanning probe images a sample at different lateral positions of the sample The optical scanning probe includes a housing having a longitudinal axis extending in a direction towards a sample to be scanned, a first base having a first moveable mirror supported thereon by a first cantilever connecting the first moveable mirror to the first base, a second base having a second moveable mirror supported thereon by a second cantilever connecting the second moveable mirror to the second base, and a support attaching the first and second bases so that the first moveable mirror and the second moveable mirror are disposed along the longitudinal axis apart from each other04-05-2012
20120280144OPTICAL SYSTEM ENABLING LOW POWER EXCITATION AND HIGH SENSITIVITY DETECTION OF NEAR INFRARED TO VISIBLE UPCONVERSION PHOSHORS - A simple yet high performance optical system is described which is tailored to enabling efficient detection of the luminescence emissions of near infrared-to-visible upconverting phosphors. The system is comprised of simple and relatively low cost optical components and is designed to telecentrically enable low optical power NIR excitation and high sensitivity VIS and NIR detection of the upconverting phosphor (UCPs), particularly the lanthanide doped UCP nanocrystals which show great promise for utility as molecular taggants in many applications of biomedicine, security and environmental monitoring. The overall system is designed to facilitate compact spectrophotometric instrument manufacture and is adaptable to multiple liquid or solid sample types and formats.11-08-2012
20120280143FLUORESCENCE DETECTING OPTICAL SYSTEM AND MULTI-CHANNEL FLUORESCENCE DETECTION APPARATUS INCLUDING THE SAME - A fluorescence detection optical system detects fluorescence beams with two or more different wavelengths and maintains a focal position through an automatic focusing function. A multi-channel fluorescence detection apparatus includes the fluorescence detection optical system. The fluorescence detection optical system includes an automatic focusing unit which receives light reflected off a microfluidic device and determines a focal point by using an astigmatic method or a knife edge method, and an actuator which adjusts a position of an objective lens according to control of the automatic focusing unit. In addition, the fluorescence detection optical system may include a plurality of dual band pass filters, dichroic devices, etc., which provide light beams emitted from at least two light sources and transfer fluorescence generated from the microfluidic device to a photodetector.11-08-2012
20120326052SIMULTANEOUS FLUORESCENCE CORRELATION SPECTROSCOPY (SFCS) - A fluorescence correlation spectroscopy apparatus for examining a specimen including an illumination grid which includes comprises light-emitting regions for illuminating the specimen; an objective arrangement that images the illumination grid into a focal plane at the location of the specimen; and a receiving grid on a receiver side, wherein after the focal plane, each orifice of the orifice plate of the observation beam path has associated with it a device for spectral dispersion of the light that has returned from the specimen; and at least two radiation receivers are associated with each device for spectral dispersion.12-27-2012
20120326053DEVICE FOR READING OUT EXPOSED IMAGING PLATES - A device for reading out and erasing imaging plates which includes an eraser disposed down-stream of a readout unit at a short distance thereof, said eraser being separated from the readout unit by a light barrier.12-27-2012
20130015366SAMPLE OBSERVATION APPARATUSAANM HAYASHI; ShinichiAACI TokyoAACO JPAAGP HAYASHI; Shinichi Tokyo JP - A sample observation apparatus includes excitation light irradiation unit to irradiate sample with excitation light; excitation light modulator to modulate spatial intensity distribution of the excitation light on the sample; excitation light modulation control unit to control the excitation light modulator according to modulation control signal; photo detection unit to detect light emission from the sample and to generate a detection signal; image generation unit to generate image data of the sample according to the modulation control signal and the detection signal; modulation control signal generation unit to generate the modulation control signal such that Nyquist frequency of the image data will be larger than cut-off frequency in the spatial intensity distribution of the excitation light on the sample; and image processing unit to emphasize high-frequency component that exceeds the cut-off frequency included in the image data.01-17-2013
20080245971Biosensors with Improved Sensitivity - A sensor is described for use with at least one optical detector (10-09-2008
20130175455LASER CAVITY TWO-PHOTON SPECTROSCOPY - A laser cavity two-photon spectroscopy includes a gain medium, a first reflector, a second reflector, an electrical pumping module, and a two-photon absorption cell. The first reflector is disposed at a side of the gain medium. The second reflector is movably disposed at a side of the gain medium relative to the first reflector. The electrical pumping module is electrically connected to the gain medium. Therefore, the gain medium is able to emit a light beam, which bounces back and forth between the first reflector and the second reflector and forms a laser beam through enhanced by the gain medium. The two-photon absorption cell disposed between the gain medium and the second reflector includes a plurality of two-photon absorption mediums. The two-photon absorption mediums absorb a portion of the laser beam reflected between the first reflector and the second reflector and then emit fluorescence.07-11-2013
20110266458FLUORESCENCE LIFE MEASURING APPARATUS, FLUORESCENCE LIFE MEASURING METHOD AND PROGRAM - A fluorescence life measuring apparatus, a fluorescence life measuring method and a program that can obtain fluorescence life using a simple configuration are proposed.11-03-2011
20130146786APPARATUS FOR GENERATING FLUORESCENCE - An apparatus for generating fluorescence comprises a blue LED emitting a light beam, a filter and a fluorescent material. The filter is arranged in front of the light beam emitted by the blue LED, receives the light beam, and converts the light beam into a filtered light beam having wavelengths of 465-505 nm. The fluorescent material is arranged in one side of the filter, which is opposite to the blue LED, to receive the filtered light beam. The fluorescent material is excited by the filtered light beam to emit fluorescence. The filter is applied to control the wavelength and spectral range of the filtered light beam to achieve the best fluorescence exciting efficiency and prevent from the overlap of the wavelength ranges of the filtered light beam and the fluorescence.06-13-2013
20110210270OPTICAL TOMOGRAPHY MEASUREMENT DEVICE - An optical tomography measurement device that includes an illumination component, a light reception component, a change component, an acquisition component and a correction component is provided. The acquisition component acquires reference data corresponding to an amount of fluorescent light received by the light reception component when an excitation light is illuminated onto the reference position, first data corresponding to the amount of fluorescent light received by the light reception component when the excitation light is illuminated onto a first illumination position, and second data corresponding to the amount of fluorescent light received by the light reception component when the excitation light is illuminated on a second illumination position. The correction component corrects the reference data so as to remove fluorescent light components emitted from a fluorescent marking agent outside of a measurement plane based on the first data and the second data.09-01-2011
20110210269Non-Linear Optical System and Techniques - Methods and systems are described using a non-linear optical system comprising a laser and a light delivery system comprising a single mode fiber, a mode converter, and a high order mode fiber, wherein the light delivery system that receives light from the source and provides a structured free-space beam having an embedded Gaussian beam. The light delivery system functions to illuminate a region of a sample and generate a non-linear response in a spatial region smaller than that associated with a Gaussian beam having a width comparable to the width of the embedded Gaussian beam. In another aspect, the light delivery system illuminates a region of a sample and generates a non-linear emission of radiation, is depicted. A further aspect of this embodiment includes an imaging assembly for detecting the non-linear emission and using a signal derived from the detected emission to generate a microscopic image of the sample.09-01-2011
20080197292Luminescence Sensor Using Multi-Layer Substrate Structure - The present invention provides a luminescence sensor (08-21-2008
20100282981LASER SCANNING MICROSCOPE - A laser scanning microscope that can construct a fluorescence image with high resolution even with a photodetector having a small array size is provided. A laser scanning microscope includes a line-focusing optical system that focuses laser light from a laser light source in the form of a line; a DMD having a plurality of movable micromirrors that are arrayed in the same direction of the line and reflect the focused laser light; a galvanometer mirror that scans the laser light reflected by the DMD; an irradiation optical system that irradiates a sample with the scanned laser light; a photodetector having a plurality of channels that detect light from the sample and are arrayed in a single line; and a controller that controls the DMD so as to cause the light reflected by the different movable micromirrors to enter the respective channels, and that sequentially switches between the micromirrors that reflect the light that is to enter the channels so that the light from different positions on the sample enters the channels.11-11-2010
20120256100Device for Reading Storage Films - In a reading device for reading storage films, a reading light beam rotating about an axis of rotation is directed onto the storage film through a reading opening of a film support. Fluorescent light returning from the storage film falls through the reading opening into a photodetector. Misreadings produced by reflected secondary reading light are reduced by the provision of a filter at the reading opening, which filter allows at least some fluorescent light to pass and attenuates reading light reflected from the storage film.10-11-2012
20110233426METHOD AND APPARATUS FOR TAGGING INDIVIDUALS FOR IDENTIFICATION AND TRACKING - A method and apparatus that are useful for tagging personnel for identification and tracking is disclosed. The apparatus may include a taggant, the taggant being a chemical substance that adheres to at least one of human skin, clothing and equipment of personnel and is undetectable by the human eye, and a taggant deployment mechanism that includes the taggant and is configured to release the taggant upon activation of a triggering mechanism, wherein the taggant deployment mechanism is configured such that when the triggering mechanism is activated, the taggant is released from the taggant deployment mechanism and adheres to at least one of human skin, clothing and equipment of personnel within a radius of a point that the taggant is released, the taggant being detectable only by a taggant detection unit.09-29-2011
20100314554DEVICE TO ILLUMINATE AN OBJECT WITH A MULTISPECTRAL LIGHT SOURCE AND DETECT THE SPECTRUM OF THE EMITTED LIGHT - A device to illuminate a object, to excite its fluorescence light emission, and detect the emitted fluorescence spectrum, comprising: at least one illumination system (12-16-2010
20110272596FLUORESCENCE DETECTOR - A fluorescence detector in which a sample substrate is provided with a structure unit comprising a prism or a diffraction grating. After excitation light falling on the sample substrate is totally reflected at a biomolecule-immobilized face that is located in the opposite side of the structure unit, the structure unit allows the emission of the reflected light therefrom. To ensure multiple visual field measurement, a sample substrate-driving unit is provided to scan the sample substrate.11-10-2011
20130153787OPTICAL DIGITIZER SYSTEM WITH POSITION-UNIQUE PHOTOLUMINESCENT INDICIA - A digitizer system including a substrate having a position-unique photoluminescent indicia pattern. A stylus component receives optical signals indicative of the indicia pattern and determines therefrom the position of the stylus relative to the substrate. Methods of disposing indicia on the substrate, and styli suitable for sensing photoluminescent indicia are also described.06-20-2013
20130119271Electrothermal Vaporization Atomic Fluorescence Spectroscopy and Spectrometer for Determination of Cadmium - An electrothermal vaporization atomic fluorescence spectrometer for determination of Cadmium comprising a sampling system, a light source, an atomizer, a light path system, a detection system, and a display device. The sampling system includes an electrothermal vaporization device and a capture trap; the capture trap comprises a Tungsten or Molybdenum coil (05-16-2013
20120018650FINE PARTICLE MEASURING DEVICE - A fine particle measuring device includes an optical filter that is divided into a plurality of areas and is disposed on an optical path on which light emitted from a fine particle, which is irradiated with light, is guided to an optical detector. In the fine particle measuring device, the optical filter includes a first area having wavelength selectivity by which the first area blocks reflected light from the fine particle and an unnecessary scattered light component and transmits fluorescence, and a second area that is disposed around at least the first area and has no wavelength selectivity so as to transmit a necessary scattered light component.01-26-2012
20130193345FLUORESCENCE OBSERVATION APPARATUS - Fluorescence observation apparatus includes laser scanning fluorescence observation unit and wide field fluorescence observation unit. The former unit includes: lasers; scanning unit that scans sample by laser light; and detector that detects fluorescence from the sample excited by the laser light. The latter unit includes: light source to planar-illuminate the sample; excitation filters that are selectively arranged on light path from the light source, and that correspond to the lasers, respectively; and two-dimensional detector that detects fluorescence from the sample excited by light that has passed through excitation filter arranged on light path from the light source. Each of the excitation filters has optical property in which center wavelength of transmissive band is approximately the same as oscillation wavelength of corresponding laser and bandwidth of transmissive band is approximately the same as tolerance width of oscillation wavelength of corresponding laser.08-01-2013
20130200272OPTICAL SYSTEM FOR FLUORESCENCE DETECTION AND FINE PARTICLE ANALYZING APPARATUS - An optical system for fluorescence detection includes two parabolic mirrors, a first parabolic mirror and a second parabolic mirror, and fluorescent light beams that are incident from different directions are reflected by the first parabolic mirror as parallel light beams to the second parabolic mirror and are converged at one point by the second parabolic mirror.08-08-2013
20130200273Fluoroscopy Apparatus, Fluoroscopy System, and Fluorescence-Image Processing Method - A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.08-08-2013
20130200274Fluoroscopy Apparatus, Fluoroscopy System, and Fluorescence-Image Processing Method - A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.08-08-2013
20130200275Fluoroscopy Apparatus, Fluoroscopy System, and Fluorescence-Image Processing Method - A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.08-08-2013
20120085928FLUORESCENCE DETECTION OPTICAL SYSTEM AND MULTI-CHANNEL FLUORESCENCE DETECTION SYSTEM INCLUDING THE SAME - A fluorescence detection optical system comprises a light source which emits excitation light, a collimating lens which condenses the excitation light emitted from the light source into substantially parallel light, an objective lens which focuses the excitation light on a microchamber of a microfluidic device, an optical detector which measures an intensity of a fluorescence signal generated in the microchamber by the excitation light, a beam splitter which transmits or reflects the excitation light emitted from the light source toward the objective lens, and reflects or transmits the fluorescence signal generated in the microchamber toward the optical detector, and a beam shaping lens which is disposed between the beam splitter and the objective lens and expands an optical spot of the excitation light in one direction in accordance with a shape of the microchamber.04-12-2012

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