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With sample supply means

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250 - Radiant energy

250281000 - IONIC SEPARATION OR ANALYSIS

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DocumentTitleDate
20100090105Ionization Device - A plate for matrix-assisted laser desorption ionization (MALDI) mass spectrometry comprising an electrically conductive substrate (04-15-2010
20090039250MASS SPECTROMETER AND METHOD OF MASS SPECTROMETRY - In a mass spectrometer having ion sources capable of switching between atmospheric pressure chemical ionization and electron impact ionization, a first gas chromatography device capable of separating a sample to meet a condition suitable for atmospheric pressure chemical ionization measurement is connected to upstream of an atmospheric pressure chemical ionization ion source. Part of the sample separated by the first gas chromatography device is introduced to a second gas chromatography device by distributing a flow channel. In the second gas chromatography device, a target substance and background ingredients contained in the sample are further separated and are introduced to an electron impact ionization ion source. By separating the target substance from the background ingredients, an electron impact ionization spectrum of the target substance is obtained without an effect of the background ingredients.02-12-2009
20100059675MASS SPECTROMETER - An object of the present invention is to provide a mass spectrometer having an optical ion transport system where the efficiency for generating and converting fragment ions can be increased, and which can transport the generated fragment ions efficiently to the rear stage, and in order to achieve this object, the mass spectrometer for ionizing a sample in an ionization chamber 03-11-2010
20090114814MICROPILLAR ARRAY ELECTROSPRAY CHIP - The invention relates to an electrospray ionization (ESI) device for forming a stream of ionized sample molecules. The device comprises a sample introduction zone for receiving a liquid-form sample, a tip for spraying the sample into aerosol or gaseous form, and a flow channel connecting the sample introduction zone and the tip. According to the invention, the flow channel comprises an array of transversely oriented microstructures adapted to passively transport the liquid-form sample introduced to the sample introduction zone to the tip by means of capillary forces. The invention concerns also a manufacturing method and applications of the ESI device, in particular mass spectrometry. The device can be used without external pumping of sample liquid.05-07-2009
20090194687ION SOURCE VESSEL AND METHODS - An ion source and method for providing ionized particles to a molecular/atomic analyser, such as a mass spectrometer, are disclosed. The ion source includes a vessel defining a channel; a gas inlet extending from the gas source into the channel, for introducing a gas flow into the channel; a sample inlet extending into the channel for introducing sample within the channel; and an ionizer to ionize the sample in the channel. The vessel is sufficiently sealed to allow the channel to be pressurized, at a pressure in excess of 100 Torr. At least one gas source maintains the pressure of the channel at a pressure in excess of 100 Torr and the pressure exterior to the channel at a pressure in excess of 0.1 Torr and provides a gas flow that sweeps across the ionizer to guide and entrain ions from the ionizer to the outlet.08-06-2009
20080230692HIGH RESOLUTION MASS SPECTROMETERY METHOD AND SYSTEM FOR ANALYSIS OF WHOLE PROTEINS AND OTHER LARGE MOLECULES - A matrix assisted laser desorption/ionization (MALDI) method and related system for analyzing high molecular weight analytes includes the steps of providing at least one matrix-containing particle inside an ion trap, wherein at least one high molecular weight analyte molecule is provided within the matrix-containing particle, and MALDI on the high molecular weight particle while within the ion trap. A laser power used for ionization is sufficient to completely vaporize the particle and form at least one high molecular weight analyte ion, but is low enough to avoid fragmenting the high molecular weight analyte ion. The high molecular weight analyte ion is extracted out from the ion trap, and is then analyzed using a detector. The detector is preferably a pyrolyzing and ionizing detector.09-25-2008
20110186731LCMS TECHNOLOGY AND ITS USES - The present invention relates to an improved LCMS technology and its uses in methods for the selective identification and characterization of immunogenic pathogen associated epitopes, and the use thereof in vaccine development. One way of bridging the knowledge gap on T cell epitopes is to apply a new platform technology, “immunoproteomics”, to directly assess the epitope display at the surface of antigen presenting cells by nanoscale mass spectrometry of extracted peptide samples. This is the only methodology that can provide unbiased insight into epitope features such as the exact molecular nature, diversity, abundance, dynamics and PTM of T cell epitopes originating from pathogen-derived proteins. Therefore, this platform technology and immunoproteomics should become an intrinsic part of vaccinology.08-04-2011
20130075603SAMPLE PRETREATMENT APPARATUS AND MASS SPECTROMETER PROVIDED WITH THE SAME - The present invention relates to a pretreatment apparatus that performs concentration and separation of a sample, and in particular, in order to provide a sample pretreatment apparatus using a solid-phase extraction column, and a mass spectrometer using the same, which is particularly suitable for clinical analysis in which qualitative/quantitative analysis of a biological sample such as blood is performed, according to each operational step for a solid-phase extraction treatment, for example, a collection device serving as flow passages or containers for collection of waste liquid or extracted matter is installed on a bottom face of the solid-phase extraction column, and the extracted matter is separately collected without being mixed with waste liquid by switching the positions of the collection device.03-28-2013
20080258054Point-of-Care Mass Spectrometer System - A point-of-care mass spectrometer system has a sampling system, an ionization component structured to receive a sample for analysis from the sampling system, a mass analyzer structured to receive a source of ions for analysis from the ionization component, and a detector structured to detect ions from the mass analyzer and to generate an output signal. The sampling system selects a subset of peptides from a sample by immunopurification of multiple histocompatability complexes and concentrates the subset of peptides to provide the sample to the ionization component.10-23-2008
20110192973Apparatus for transmission of energy and/or for transportation of an ion as well as a particle beam device having an apparatus such as this - An apparatus for transmission of energy of an ion to at least one gas particle and/or for transportation of an ion and a particle beam device having an apparatus such as this are disclosed. In particular, a container is provided, in which a gas is arranged which has gas particles, wherein the container has a transport axis. Furthermore, at least one first multipole unit and at least one second multipole unit are provided, which are arranged along the transport axis. The first multipole unit and the second multipole unit are formed by printed circuit boards. Furthermore, an electronic circuit is provided, which provides each multipole unit with a potential, such that a potential gradient is generated, in particular along the transport axis.08-11-2011
20090250608Ion Sources For Improved Ionization - Improved apparatuses and methods are provided for ionizing samples and analyzing the samples with mass spectrometry.10-08-2009
20130037711INTRODUCTION OF IONS INTO ELECTROSTATIC ION TRAPS - Ions are introduced into a Kingdon ion trap in which the ions can oscillate harmonically in a potential well in the longitudinal direction, essentially decoupled from their transverse motion by a Kingdon ion guide, which can consist of a drill-hole through the wall of the ion trap housing electrodes and a central wire. An injection potential is first applied to the wire, but once the heaviest ions of interest have been injected into the trap, the potential of the wire is switched to the potential of the housing electrodes, to trap the ions in the trap. The ions introduced into the Kingdon ion trap may come from a small ion cloud, located in a Paul trap.02-14-2013
20130032711Mass Spectrometer - A unit which calculates a diameter of a throttle part of a valve and a diameter of an orifice from changes of vacuum degrees measured by vacuum gauges disposed in an ion source and a vacuum chamber having a mass analysis part in order to maintain a flow rate of reagent gas flowing in the ion source to be always fixed and changes vacuum degree in a reagent introduction part, the ion source or the vacuum chamber in order to correct difference from standard value is provided. A unit which measures discharge voltage, discharge current and plasma luminous intensity to grasp current situation in order to maintain plasma generation state in the ion source to be fixed and changes discharge condition such as discharge voltage in order to correct change part from standard value is provided.02-07-2013
20130032710Moldable Ceramics for Mass Spectrometry Applications - A glass ceramic including an alkali metal earth oxide, e.g. SrO suitable for overmolding a RF component provides a good RF response and good mechanical robustness. Specifically, SrO reduces the flow temperature of the ceramic while maintaining the RF and mechanical performance. The resulting glass formulation contains 10-50 mol % SrO, 5-30 mol % Al02-07-2013
20100044563MASS SPECTROMETER - A sample plate 02-25-2010
20100102221APERTURED DIAPHRAGMS BETWEEN RF ION GUIDES - An apertured diaphragm disposed with an RF ion guide includes at least one of a weakly conductive solid dielectric material and a non-conducting dielectric with a weakly conducting surface layer.04-29-2010
20090159795DEVICE FOR THE ANALYSIS OF ISOTOPE RATIOS - A method for the analysis of isotope ratios, wherein at least one sample gas and/or at least one reference gas are supplied to at least one analytical device via at least one open split, the addition of a carrier gas also being possible. According to the invention, the concentration of the sample gas and/or reference gas passing into the analytical device is controlled by the supply of the respective carrier gas or by direct supply of the sample gas into the analytical device. In the device according to the invention for supplying gases to at least one analytical device, two or more capillaries are provided for sample gases, the capillaries in each case having their own drive for the movement between mixing zone and waiting zone.06-25-2009
20090159794METHOD AND AN ION SOURCE FOR OBTAINING IONS OF AN ANALYTE - A method of obtaining ions of an analyte is disclosed. The method includes aerosolizing a sample using a thermal liquid jetting device or a piezoelectric liquid jetting device to obtain an aerosol without ionizing the sample. The sample includes the analyte in a solvent. The method further includes drying the aerosol to obtain gas phase solvent and gas phase analyte, and ionizing the gas phase analyte to obtain ions thereof. An ion source using the method for obtaining ions of an analyte is also disclosed.06-25-2009
20090127455Ion guide for mass spectrometers - The present invention relates generally to mass spectrometry and the analysis of chemical samples, and more particularly to ion guides for use therein. The invention described herein comprises an improved method and apparatus for transporting ions from a first pressure region in a mass spectrometer to a second pressure region therein. More specifically, the present invention provides a segmented ion funnel for more efficient use in mass spectrometry (particularly with ionization sources) to transport ions from the first pressure region to the second pressure region.05-21-2009
20130082172APPARATUS FOR CHEMICAL SAMPLING AND METHOD OF ASSEMBLING THE SAME - A chemical sampling system includes a direct analysis in real time (DART) device and an atmospheric pressure photoionization (APPI) device positioned proximate the DART device. Another chemical sampling system includes the APPI device positioned proximate to a thermal desorption device.04-04-2013
20120181424FAIMS Having a Displaceable Electrode for On/Off Operation - A system for analyzing ions comprises: an ion source; a FAIMS cell comprising: (a) a gas inlet; (h) an outer electrode having a generally concave inner surface and comprising: (i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and (ii) an ion outlet; and (c) an inner electrode having a conduit therethrough and having a generally convex outer surface disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode defining at least one annular on separation region therebetween; and a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet, wherein the inner electrode is moveable between a first position and a second position, the first and second positions facilitating movement of the ions through the at least one annular ion separation region and the conduit, respectively.07-19-2012
20120181423KINGDON ION TRAPS WITH HIGHER-ORDER CASSINI POTENTIALS - An electrostatic Kingdon ion trap in which ions can oscillate harmonically in the longitudinal direction, decoupled from their motions in the transverse direction is formed from at least three inner electrodes located inside a hollow outer housing electrode. The inner surface of the housing electrode and the outer surfaces of the inner electrodes are formed so that when a potential is applied between the housing and the inner electrodes, the potential distribution inside the housing contains not only a term for a harmonic potential well in the axial direction, but also a term for the potential distribution in the radial direction, that contains, independent of the axial coordinate, the equations for a family of Cassini curves of at least the third order.07-19-2012
20090045334MASS SPECTROMETER USING A DYNAMIC PRESSURE ION SOURCE - A mass spectrometer has a pulsed ion source, a first ion trap (02-19-2009
20090045332SUBSTRATE FOR MASS SPECTROMETRY, MASS SPECTROMETRY, AND MASS SPECTROMETER - Provided is a substrate for mass spectrometry, which enables a detection of a high molecular weight compound to be conducted at a high sensitivity, and can avoid the fragmentation so that there is substantially no obstacle to the analysis of a low molecular weight region. The substrate is a substrate for mass spectrometry for use in laser desorption/ionization mass spectrometry, containing a metal and having a porous structure on a surface thereof, wherein at least one functional group selected from the group consisting of a carboxyl group, a sulfonic group and an ammonium chloride group is covalently bonded to the surface of the substrate.02-19-2009
20120217389ELECTROSPRAY IONIZATION FOR CHEMICAL ANALYSIS OF ORGANIC MOLECULES FOR MASS SPECTROMETRY - An electrospray ionization laboratory on a chip for in situ detection of organic molecules includes a substrate, an input for accepting organic molecule samples, an enrichment column for concentrating organic molecule samples and delivering a concentrated sample to a micro fluidic channel, an analytical column connected in serial to the enrichment column for accepting the concentrated sample, a detector for accepting a pressurized fluid output from the analytical column, and an output nozzle assembly for generating an electrospray output for mass spectrometry analysis. The nozzle assembly may include 1, 2 or 4 (arranged in a rectangular fashion) nozzles.08-30-2012
20110006201GC-MS ANALYSIS APPARATUS - GC-MS analysis apparatus has an interface section between GC and MS sections, which is located with respect to the direction of an analyte flow downstream of the GC section and upstream of the MS section. The interface section comprises at least one membrane with at least one orifice capable of establishing a molecular flow condition in the analyte passing between the GC and MS sections through the membrane. The membrane is subjected to a pressure differential such that the pressure p01-13-2011
20130056633MASS SPECTROMETER - A mass spectrometer having a resolution improved by introducing ions into a mass spectrometry part with a high efficiency is provided with a small-sized, simple configuration. The mass spectrometer includes an opening/closing mechanism provided between a sample introducing piping part for introducing a sample into the mass spectrometry part and the mass spectrometry part to conduct gas introduction intermittently and control sample passage. The mass spectrometer further includes a pump mechanism to evacuate a high pressure side of the sample introducing piping part, that is, an opposite side of the opening/closing mechanism to the mass spectrometry part to have a pressure in a range of 100 to 10,000 Pa.03-07-2013
20130056632Detectors And Ion Sources - A field asymmetric ion mobility spectrometer (FAIMS) has an analyte ion source assembly by which an analyte substance is ionized and supplied to the inlet of the spectrometer. The ion source assembly has an upstream source of clean, dry air and two ion sources of opposite polarity arranged at the same distance along the flow path. The ion sources are arranged so that the overall charge of the plasma produced is substantially neutral. The analyte substance is admitted via an inlet downstream of the ion sources and flows into a reaction region of enlarged cross section to slow the flow and increase the time for which the analyte molecules are exposed to the plasma.03-07-2013
20120112061MASS SPECTROMETER - A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample. The ion source has its interior reduced in pressure by differential pumping from the mass spectroscopy section and ionizes the gas when the interior pressure rises as it inhales the gas, and the mass spectroscopy section separates the ionized measurement sample when its interior pressure falls after inhale of the gas. The mass spectrometer may further include a restriction device for suppressing a flow rate of the gas the ion source inhales and an open/close device for opening and closing a flow of the gas the ion source inhales.05-10-2012
20100127167ATMOSPHERIC PRESSURE ION TRAP - An ion trap instrument working at atmospheric pressure, which alleviates requirements of bulky, power consuming vacuum pumps. Traps can accumulate selected ion species, effectively concentrating the analyte of interest and allowing laser spectroscopy to be performed. This lowers the detection threshold of this instrument compared to others and increases the selectivity.05-27-2010
20120223226Introducing An Analyte Into A Chemical Analyzer - A chemical pre-concentrator includes a conduit defining a flow path between two ends and having a heating element disposed within the conduit, such that the heating element has at least one sorbent material deposited directly on at least a portion of a conductive surface of the heating element. Some such heating elements are in the form of electrically conductive strips defining both a plurality of apertures through the strip and a series of undulations spaced along the flow path.09-06-2012
20130161510METHOD AND APPARATUS FOR ADJUSTING RADIATION SPOT SIZE - An apparatus can include a first beam cropper configured to crop a portion of a radiation pulse having a first spot size to form an intermediate cropped radiation pulse having an intermediate cropped spot with an intermediate cropped spot size less than the first spot size; and a second beam cropper configured to crop the intermediate cropped spot to form a second cropped radiation pulse having a second cropped spot with a second cropped spot size less the intermediate cropped spot size.06-27-2013
20090236519PARTICLES - Particles in a mobile solid phase for chromatographic separation of sample components are disclosed. These particles comprise a core and a coating, wherein said core interacts with at least one analyte and said coating essentially prevents flocculation or aggregation. The core is preferably a polymer and the analyte is preferably detected with a mass analyzer with an angled ionization source.09-24-2009
20090236518MASS SPECTROMETER - In a liquid chromatograph mass spectrometer having an ionization interface capable of simultaneously performing ionization operations by ESI and APCI, a spray nozzle 09-24-2009
20130068946THERMO-STABILIZED NANO- AND MICRO- FLOW LC/ESI-MS INTERFACE AND A METHOD THEREOF - A liquid chromatography interface is provided having an integrated column/ESI tip assembly including a liquid chromatography separation column, an ESI tip for generating ions having at least one emitting channel, and a temperature-controlled enclosure surrounding the liquid chromatography separation column. The enclosure has at least one opening and the ESI tip is exposed outside the enclosure through the opening. The enclosure has a heating or cooling device providing a substantially homogeneous distribution of temperature throughout an internal space of the enclosure where the liquid chromatography separation column is disposed. The enclosure includes at least one gas flow mixing element to permit heat exchange by directing a flow of gas toward the ESI tip. The integrated column/ESI tip assembly resides within a thermo-stabilized volume of substantially the same temperature from an entrance of the liquid chromatography separation column to the outlet of the ESI tip.03-21-2013
20090242756INTENSIFIED NEUTRAL LOSS TAGS AND USE THEREOF IN MASS SPECTROMETRY - Ultrasensitive detection of a chemical substance (analyte) by mass spectrometry is achieved by employing a molecular tag that yields an intense parent ion and then an intense daughter ion in a multi-stage mass spectrometer.10-01-2009
20130214153DEVICES AND SYSTEMS INCLUDING A BOOST DEVICE - A device for mass spectroscopy comprising a chamber configured to provide an atomization source, a boost device configured to provide radio frequency energy to the chamber, and a mass analyzer in fluid communication with the chamber and configured to separate species based on mass-to-charge ratios is disclosed. In certain examples, a boost device may be used with a flame or plasma to provide additional energy to a flame or plasma to enhance desolvation, atomization, and/or ionization.08-22-2013
20130214154SYSTEM AND METHOD FOR IONIZATION OF MOLECULES FOR MASS SPECTROMETRY AND ION MOBILITY SPECTROMETRY - An ionizing system includes a channel having an inlet disposed in a first pressure region and an outlet disposed in a second pressure region, a pressure of the first pressure region being greater than a pressure of the second pressure region. A heater is coupled to the channel and configured to heat the channel. A device is configured to introduce an analyte into the channel where the analyte is ionized.08-22-2013
20090026366MASS SPECTROMETER - In conventional mass spectrometers, if ions are converged by a radio-frequency electric field under the condition of relatively high gas pressure, the ions are decelerated and are delayed, or stagnated in an extreme case, to cause a decrease in the detection sensitivity or an appearance of a ghost peak. By contrast, in the mass spectrometer according to the present invention, lens electrodes 01-29-2009
20090008548CHROMATOGRAPH MASS SPECTROMETER - A chromatograph mass spectrometer is provided for obtaining the information pertinent to a structural analysis, with a simple operation, on a compound series including a plurality of compounds whose structures and characters are similar. First, based on the data obtained by a normal LC/MS analysis, a two-dimensional isointensity line graph is created and displayed with a retention time and a mass-to-charge ratio on the two axes and with a signal intensity represented in contour (S1 and S2). When the operator specifies a desired range by a drag operation or the like by a mouse (S3), peaks included in the range specified are extracted and based on the peaks, precursor ions are selected (S4 through S6). Then a schedule is created so that an MS01-08-2009
20090008547ATMOSPHERIC PRESSURE ION SOURCE PERFORMANCE ENHANCEMENT - Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications. Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as H+ or other cation to effect ionization of a sample species. Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ES ion signal amplitude detected by a mass spectrometer (MS). Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal. A new set of Electrolytes has been found that increases positive and negative polarity analyte ion signal measured in ESMS analysis when compared with analyte ESMS signal achieved using more conventional electrolytes. The new electrolyte species increase ES MS signal when added directly to a sample solution or when added to a second solution flow in an Electrospray membrane probe. The new electrolytes can also be added to a reagent ion source configured in a combination Atmospheric pressure ion source to improve ionization efficiency.01-08-2009
20090008546Bi-Directional System For Mass Spectrometry - The present invention relates to a system and method for mass spectrometry (01-08-2009
20100006753Extraction detection system and method - An apparatus, system and method for the continuous flow extraction, collection and analysis of small amounts of energetic substance/s and their reacted/unreacted residue/s in real time are provided. The apparatus includes an agitator that generates a particulate material from a surface. A vacuum gathers particulate material which is provided to a mixing module. The mixing module creates a supercritical matrix containing the particulate matter. A separator separates and removes waste in the supercritical matrix from the supercritical matrix. Concentrated particulate material from the supercritical matrix is provided to a mass spectrometer for analysis and detection of a target material in proximate real-time. In one embodiment, the separator provides the supercritical matrix to a tube arm. The tube arm is heated to reduce solvent in the supercritical matrix. A collector in the tube arm concentrates particulate material, which is volatilized by a laser. Volatilized particulate material is provided to the mass spectrometer. In another embodiment, the separator provides the supercritical matrix to an electrospray or APCI module whose output is provided direct to the mass spectrometer.01-14-2010
20120097846IONIZATION PROBE ASSEMBLIES - The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.04-26-2012
20090321632SYSTEM AND METHOD FOR REDUCING PARTICLES AND CONTAMINATION BY MATCHING BEAM COMPLEMENTARY APERTURE SHAPES TO BEAM SHAPES - An ion implantation system comprising an ion source configured to generate an ion beam along a beam path, a mass analyzer is located downstream of the ion source wherein the mass analyzer is configured to perform mass analysis of the ion beam and a beam complementary aperture located downstream of the mass analyzer and along the beam path, the beam complementary aperture having a size and shape corresponding to a cross-sectional beam envelope of the ion beam.12-31-2009
20110284740MS/MS Mass Spectrometer - A mass analysis of a standard sample having a known mass-to-charge ratio is carried out by performing a mass scan at a first-stage quadrupole (11-24-2011
20110291002GAS ANALYZER - This invention is to high-pressurize the maximum pressure for use of a gas analyzer, and comprises an ionizing part having an opening part to lead out ions of a sample gas to the outside, an ion drawing electrode arranged outside of the opening part of the ionizing part, a quadrupole part that selectively passes the ions lead out to the outside by the ion drawing electrode, and an ion detecting part that detects the ions passing the quadrupole, and an opening size of the opening part of the ionizing part is set to be smaller than an imaginary inscribing circle inscribed on all of four pole electrodes constituting the quadrupole part.12-01-2011
20100090104ELECTRO-DYNAMIC OR ELECTRO-STATIC LENS COUPLED TO A STACKED RING ION GUIDE - A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).04-15-2010
20110291005MASS SPECTROMETER - A cathode configuration for emission of electrons has a reaction zone connected to an entrance opening for the supply of neutral particles. The opening communicates with the cathode configuration for the ionization of the neutral particles and an ion extraction system communicates with the reaction zone. Ions from the extraction system are sent to a detection system and a mechanism for the evacuation of the mass spectrometer arrangement. The cathode configuration includes a field emission cathode with an emitter surface, wherein at a short distance from this emitter surface, an extraction grid is disposed for the extraction of electrons, which grid substantially covers the emitter surface. The emitter surface encompasses herein at least partially a hollow volume such that a tubular structure is formed.12-01-2011
20110291004SAMPLE PRETREATMENT APPARATUS AND MASS SPECTROMETER PROVIDED WITH THE SAME - The present invention relates to a pretreatment apparatus that performs concentration and separation of a sample, and in particular, in order to provide a sample pretreatment apparatus using a solid-phase extraction column, and a mass spectrometer using the same, which is particularly suitable for clinical analysis in which qualitative/quantitative analysis of a biological sample such as blood is performed, according to each operational step for a solid-phase extraction treatment, for example, a collection device serving as flow passages or containers for collection of waste liquid or extracted matter is installed on a bottom face of the solid-phase extraction column, and the extracted matter is separately collected without being mixed with waste liquid by switching the positions of the collection device.12-01-2011
20080315084ANALYSIS METHOD OF AMINO ACID USING MASS SPECTROMETER - A pretreatment method of samples, in which injections of samples are performed efficiently and precisely when amino acids are analyzed with a mass spectrometer, is provided. For the analysis method of samples including analyte comprising an amino acid, an amine and/or a peptide with mass spectrometry, the analyte is derivatized with a modification reagent, the derivative is subjected to a microchip electrophoresis, and then eluate from the microchip electrophoresis is introduced into a mass spectrometer.12-25-2008
20120097845Atmospheric Pressure Ionization Inlet for Mass Spectrometers - Methods and systems for mass spectrometry and more particularly to an interface providing charged particles to a mass spectrometer are described herein.04-26-2012
20120097844Dual Source Mass Spectrometry System - In or for a dual source mass spectrometry system (04-26-2012
20100264307MASS SPECTROMETER - In a conventional mass spectrometer in which a pipe to be electrically heated is provided between a separation wall separating an ionization chamber for ionizing a sample and a separation wall separating an analysis chamber, and an ion in the ionization chamber is introduced through the pipe to the analysis chamber, the pipe is attached or detached by screwing or unscrewing a connector portion of an electrode connected to the pipe and a connector portion of a support disposed at the separation wall. However, with this structure, the screw needs to be loosened until it is completely unscrewed every time it is washed or exchanged, and thus the operability is deteriorated. According to the present invention, a screw hole for screwing the electrode connector portion is in the form of a cut-out portion facing in the direction of rotation centering on an axis of the pipe. Accordingly, the pipe can be attached or detached by only loosening the screw without completely unscrewing it.10-21-2010
20090189073MASS SPECTROMETRY SYSTEM - A mass spectrometry system, in which a sample is introduced into each of a triple quadrupole-type mass spectrometry apparatus and another mass spectrometry apparatus, approximately concurrently in a parallel manner. The triple quadrupole-type mass spectrometry apparatus is operable to perform a neutral loss scan, and, when a specific ion is detected, a data processing section is operable to instruct a control section to initiate a mass spectrometric analysis in the other mass spectrometry apparatus. The control section is operable to control each device of the other mass spectrometry apparatus to allow the other mass spectrometry apparatus to perform a mass spectrometric analysis for the specific ion with a high degree of accuracy. A data integration processing section is operable to integrate respective analysis results obtained by data processing sections as if they are obtained from a single mass spectrometry apparatus.07-30-2009
20110266438Mass Spectrometer - A mass spectrometer capable of obtaining a clear microscopic observation image with high spatial resolution in real time, even during a mass analysis, without affecting the analysis is provided. An aperture 11-03-2011
20110133078Analytical Instruments, Assemblies, and Methods - Person-portable mass analysis instrumentation configured to perform multidimensional mass analysis is provided. Mass analysis instrumentation can include a housing encompassing components of the instrumentation with the housing of the instrumentation defining a space having a volume of equal to or less than about 100,000 cm06-09-2011
20100078553ATMOSPHERIC PRESSURE IONIZATION (API) INTERFACE STRUCTURES FOR A MASS SPECTROMETER - Atmospheric pressure ionization (API) interface structures such as API interface structures for mass spectrometers and related components, systems and methods are described herein.04-01-2010
20110192974Preparation of Test Plates for Matrix Assisted Laser Desorption Ionization - The present invention is directed, sample test plates that can be used in matrix assisted laser desorption ionization. These plates have an etched surface and a layer of MALDI matrix material. The invention also includes methods for making these sample test plates and to methods for using the plates in the MS imaging of cell and tissue samples.08-11-2011
20100084552QUADRUPOLE MASS SPECTROMETER - Disclosed is a quadrupole mass spectrometer, which is capable of, during an SIM measurement, maximally reducing a settling time-period necessary for an operation of changing an input voltage to a quadrupole mass filter in a staircase pattern, and preventing unwanted ions from excessively entering a detector during a course of changing between a plurality of mass values. Under a condition that a response speed of a DC voltage U to be applied to quadrupole electrodes is less than that of an amplitude of a high-frequency voltage V, a control section 04-08-2010
20090014644IN-SITU ION SOURCE CLEANING FOR PARTIAL PRESSURE ANALYZERS USED IN PROCESS MONITORING - An ion source apparatus for partial pressure analyzers and in-situ cleaning method thereof based on inducing a hollow cathode discharge (HCD) inside the ion source. The HCD is formed by applying a high negative voltage to one or more parts of the ion source, including the anode electrode, the lens focus plate and at least one other lens or other form of plate, such as a total pressure collector plate.01-15-2009
20090090862MASS SPECTROMETER - An electrically conductive heat-blocking plate 04-09-2009
20090294660SINGLE AND MULTIPLE OPERATING MODE ION SOURCES WITH ATMOSPHERIC PRESSURE CHEMICAL IONIZATION - An Atmospheric Pressure Chemical Ionization (APCI) source interfaced to a mass spectrometer is configured with a corona discharge needle positioned inside the APCI inlet probe assembly. Liquid sample flowing into the APCI inlet probe is nebulized and vaporized prior to passing through the corona discharge region all contained in the APCI inlet probe assembly Ions produced in the corona discharge region are focused toward the APCI probe centerline to maximize ion transmission through the APCI probe exit. External electric fields penetrating into the APCI probe exit end opening providing additional centerline focusing of sample ions exiting the APCI probe. The APCI probe is configured to shield the electric field from the corona discharge region while allowing penetration of an external electric field to focus APCI generated ions into an orifice into vacuum for mass to charge analysis. Ions that exit the APCI probe are directed only by external electric fields and gas flow maximizing ion transmission into a mass to charge analyzer. The new APCI probe can be configured to operate as a stand alone APCI source inlet probe, as a reagent ion gun for ionizing samples introduced on solids or liquid sample probes or through gas inlets in a multiple function ion source or as the APCI portion of a combination Electrospray and APCI multiple function ion source. Sample ions and gas phase reagent ions are generated in the APCI probe from liquid or gas inlet species or mixtures of both.12-03-2009
20090272897ELECTROSPRAY SYSTEMS AND METHODS - Electrospray systems, electrospray structures, removable electrospray structures, methods of operating electrospray systems, and methods of fabricating electrospray systems, are disclosed.11-05-2009
200902836753D ION TRAP AS FRAGMENTATION CELL - In a tandem mass spectrometer with mass selector spatially separated from a mass analyzer, ions are fragmented in a three-dimensional RF by electron transfer dissociation. The fragment ions are then extracted from the 3D ion trap and introduced into the mass analyzer. The extraction is accomplished by providing, in one of the ion trap end cap electrodes, an aperture with a relatively large area covered by a conductive mesh or formed by closely spaced smaller apertures. The fragment ions are extracted from the RF ion trap by applying a DC voltage to one of the end cap electrodes.11-19-2009
20090283674Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method - An interface for atmospheric pressure ionization sources has an ion transfer tube with a plurality of passageways through a sidewall such that background gas can be pumped away before it reaches an exit end of the ion transfer tube. A flow of the background gas out the exit end is reduced, and a proportion of laminar flow in the ion transfer tube may be increased. Pressure in the ion transfer tube is also reduced and desolvation is increased. In one embodiment, an enclosure surrounds an inner tube of the ion transfer tube within a first vacuum chamber such that the enclosure provides a reduced pressure region within the first vacuum chamber. Overall, transport efficiency is increased.11-19-2009
20110168883MASS SPECTROMETER - A mass spectrometer is provided that restrains the signal intensity of an MS/MS spectrum from decreasing according to the secondary dissociation of a primary fragment ion generated by a photodissociation. An excitation laser light for causing a photodissociation is irradiated to the trapping space A in the ion trap 07-14-2011
20090261244MICROENGINEERED NANOSPRAY ELECTRODE SYSTEM - This invention provides a method of aligning a nanospray capillary needle, a set of electrodes, and a capillary input to a mass spectrometer. The electrode system is formed using microengineering technologies, as an assembly of two separate chips. Each chip is formed on an insulating plastic substrate. The first chip carries mechanical alignment features for the capillary electrospray needle and the API mass spectrometer input, together with a set of partial electrodes. The second chip carries a set of partial electrodes. The complete electrode system is formed when the chips are assembled in a stacked configuration, and consists of an einzel lens capable of initiating a Taylor cone and separating ions from neutrals by focusing.10-22-2009
20090261245GC-MS ANALYZER SWITCHABLE BETWEEN ONE-DIMENSIONAL AND TWO-DIMENSIONAL MODES - One-dimensional GC-MS/olfactory analysis and two-dimensional GC-MS/olfactory analysis can be freely performed in one analyzer by a simple switching operation, without changing the device configuration. An odor component analyzer is used which includes a sample injection port equipped with a pressure control device, a GC first dimensional column connected to the sample injection port, a three-way connector T10-22-2009
20090266984Plasma Ion Source Mass Spectrometer - Provided is a plasma ion source mass spectrometer with an ion deflector lens having an improved removal ratio of photons and neutral particles as compared with the conventional art while an ion transmittance is maintained. The ion deflector includes an input side plate-like electrode, an output side plate-like electrode, and a tubular electrode disposed between the input side plate-like electrode and the output side plate-like electrode. The tubular electrode is of a point asymmetrical configuration. The tubular electrode is arranged so that a center axis of the tubular electrode is closer to an axis of travel of ions upstream of the input side plate-like electrode than an axis of travel of ions downstream of the output side plate-like electrode.10-29-2009
20080245964Method and Apparatus for Detecting Surface and Subsurface Properties of Materials - A method and apparatus for remotely monitoring properties of gases and plasmas, and surface and sub-surface properties of materials, is disclosed. A laser beam is focused at a desired region within a gas, plasma, or material (e.g., solid or liquid) to be analyzed, generating an ionized sample region or a localized, enhanced free carrier region. A beam of microwave radiation is directed toward the ionized sample region or the free carrier region, and the microwave radiation is scattered. The scattered microwave radiation is received by a microwave receiver, and is processed by a microwave detection system to determine properties of the gas, plasma, or material, including surface and sub-surface properties.10-09-2008
20080245963Method and Apparatus for Generation of Reagent Ions in a Mass Spectrometer - A front-end ion source for a mass spectrometer generates both analyte and reagent ions. The reagent source may include a heater for vaporizing a condensed-phase reagent substance and an electron source for ionizing reagent molecules. The interior of the reagent ionization chamber is purged with a purge gas to avoid or minimize reaction of the reagent ions with oxygen or other reactive species, thereby enabling operation of the reagent ionization chamber at or near atmospheric pressure. The reagent and analyte ions are directed into a reduced-pressure chamber through separate passageways. An ion transport optic selectively transmits one of the analyte ions or the reagent ions from the reduced-pressure chamber to downstream regions of the mass spectrometer.10-09-2008
20110266437Method for chemical analysis and apparatus for chemical analysis - There are provided a method for chemical analysis and an apparatus for chemical analysis. The method for chemical analysis includes: dosing a targeted sample with ionizing gas; irradiating ion beams on the targeted sample; and analyzing the mass of fragment ions and molecular ions sputtered from the targeted sample by the collisional impact of the ion beams . The apparatus for chemical analysis includes: an ionizing gas doser that adds ionizing gas onto a targeted sample disposed in a vacuum chamber; an ion beam source that generates ion beams and irradiates them onto the targeted sample; and a mass spectrometer that analyzes the mass of fragment ions and molecular ions sputtered from the targeted sample by the collisional impact of the ion beams.11-03-2011
20100102222SAMPLING SYSTEM FOR USE WITH SURFACE IONIZATION SPECTROSCOPY - In various embodiments of the invention, a device permits more efficient collection and transmission of ions produced by the action of a carrier gas containing metastable neutral excited-state species into a mass spectrometer. In one embodiment of the invention, the device incorporates the source for ionization in combination with a jet separator to efficiently remove excess carrier gas while permitting ions to be more efficiently transferred into the vacuum chamber of the mass spectrometer. In an embodiment of the invention, improved collection of ions produced by the carrier gas containing metastable neutral excited-state species at greater distances from between the position of the analyte and the position of the mass spectrometer are enabled.04-29-2010
20110198496Mass Spectrometer - When a sample plate 08-18-2011
20080237459Ion source and mass spectrometer instrument using the same - An ion source includes a body having a gas passage and an orifice. A capillary is inserted into the gas passage so that a tip portion of the capillary extends into the orifice. A gas supplier supplies a gas into the gas passage to form a gas flow through the gas passage along the capillary and through the orifice past a tip of the capillary so that the gas flow sprays a sample solution flowing through the capillary from the tip of the capillary. A flow controller regulates a pressure of the gas in the gas passage to adjust a characteristic value F/S to a predetermined value, where F is a flow rate of the gas flow at standard conditions (20.degree. C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of the tip portion of the capillary in the orifice.10-02-2008
20090166532DRIFT TUBE STRUCTURE FOR ION MOBILITY SPECTROMETER - A drift tube structure for ion mobility spectrometer is disclosed comprising electrode sheets and insulation parts arranged in alternation, with each electrode sheet being a mesh metal sheet having a radian or taper portion which is convexly curved toward an ion input. Further, the radian or taper portion of the electrode sheet has meshes of higher transparency. With the above structure of the present invention, an electric field having a periphery of uniform focusing center can be formed in the migration zone. The circular ring configuration of the electric field periphery can shield the migration electric field from any influence of external electric fields. The electrodes are each meshlike and have a circular hole at the center, thus they can focus and collect as many as possible ions that do not move along the central axis, and those ions moving along the central axis can pass through the electrodes transparently.07-02-2009
20090166531APPARATUS AND METHOD FOR GENERATING AN AMMONIA GAS - Apparatus and method for generating ammonia gas. In one aspect, a method for generating ammonia gas for use in an ion mobility spectrometry (IMS) system is provided. The method includes inserting a device into a space defined within the IMS system, the device including an ammonia compound. The method also includes activating to decompose and to produce the ammonia gas without producing water vapor. The method also includes emitting the ammonia gas into the IMS system.07-02-2009
20080283741Sample introduction device for mass spectroscope - A sample solution introduction device for a mass spectroscope includes a container device including a container having an opening at a top portion thereof and a blocking plug for blocking the opening, a gas supply device for supplying predetermined gas into the container, a first inner container provided inside the container, and an inner container supporting device for suspending and supporting the first inner container to the blocking plug. A liquid transmission pipe passes through the blocking plug. The liquid transmission pipe has one end to be soaked in a liquid sample inside the first inner container, and the other end located outside the container. The liquid sample is pushed by gas pressure supplied by the gas supply device.11-20-2008
20080283740MASS SPECTROMETRY SYSTEM AND MASS SPECTROMETRY METHOD - When a liquid mixture of two samples such as biological samples labeled with stable isotopes is subjected to a relative quantitative analysis using a liquid chromatography-tandem mass spectrometry system, various constituents are simultaneously ionized. Accordingly, sufficient time required for second mass spectrometry is not ensured, whereby some ions remain unanalyzed after measurement. To address this problem, after second mass spectrometry, amino acid sequencing is performed using the analysis data of the second mass spectrometry, which enables determination on the presence/absence of a specific amino acid labeled with a stable isotope. When the specific amino acid is present, the m/z value of an isotopically-labeled-paired ion in an MS spectrum is calculated, and non-target information for use in second mass spectrometry is created using the calculated m/z information. This avoids redundant second mass spectrometry on sample components derived from the same peptide while allowing second mass spectrometry to be efficiently performed.11-20-2008
20080283739Apparatus and Methods for Mass-Spectrometric Directed Purification of Biopolymers - A method for extracting at least one target compound from a sample includes injecting an overloaded amount of the sample into a chromatographic conduit (11-20-2008
20080290270STRUCTURED CARBON NANOTUBE TRAY FOR MALDI PLATES - An apparatus for producing analyte ions for detection by a mass spectrometer is described. The apparatus includes an ion source in which the surface of a target substrate for holding an analyte sample includes structured carbon nanotube material. The structured carbon nanotube material is structured in terms of being situated on a selected portion of the target support surface an/or in terms of being aligned in a selected orientation.11-27-2008
20080290271METHOD FOR LASER DESORPTION/IONIZATION MASS SPECTROMETRY, SAMPLE SUPPORTING SUBSTRATE USED THEREIN, AND SUBSTRATE MATERIAL TESTING METHOD - There is disclosed a method of performing laser desorption/ionization mass spectrometry based on ions generated by exposing a sample supported on a substrate to laser light, the sample being to be subjected to spectrum analysis. The method includes the steps of (a) causing a part of the ions to be generated through one of an interaction between the laser light and a surface of the substrate and an interaction between the laser light and an interface between the substrate and the sample; and (b) determining the generated part of the ions to be index ions and identifying a signal to become noise in the laser desorption/ionization mass spectrometry using a signal of the index ions, thereby performing the spectrum analysis without an effect of the noise.11-27-2008
20080290272MASS SPECTROSCOPY DEVICE AND MASS SPECTROSCOPY SYSTEM - A mass spectroscopy device constituted by a first reflector which is partially transparent and partially reflective, a transparent body, and a second reflector which is reflective. The first reflector and the second reflector are arranged on opposite sides of the transparent body so as to form an optical resonator in such a manner that when a specimen containing an analyte subject to mass spectroscopy is arranged in contact with a surface of the first reflector, and the surface is irradiated with measurement light, optical resonance occurs in the optical resonator, and intensifies an electric field on the surface, and the intensified electric field desorbs the analyte from the surface.11-27-2008
20120292501MASS SPECTROMETER - A mass spectrometer of ionizing a sample by a dielectric barrier discharge under a reduced pressure. An ionization with inconsiderable fragmentation can be carried out highly sensitively by the present invention.11-22-2012
20100276588Microengineered ionisation device - This invention provides a method of aligning a capillary needle, a set of electrodes, and an input to a mass spectrometer. The electrode system is formed as an assembly of two separate chips and forms an ionisation device. Each chip is formed on an insulating plastic substrate. The first chip carries mechanical alignment features for the capillary electrospray needle together with a set of partial electrodes. The second chip carries a set of partial electrodes. The complete electrode system is formed when the chips are assembled in a stacked configuration.11-04-2010
20080272293Reversed Geometry MALDI TOF - The TOF mass spectrometer disclosed places an even number of ion mirrors in close proximity to a MALDI ion source and a field-free drift space between the exit from the mirrors and an ion detector. This “reversed geometry” configuration may be distinguished from a conventional reflecting TOF analyzer employing a single ion mirror where a large fraction of the total drift space is located between the ion source and the mirror.11-06-2008
20120292500MASS SPECTROMETER SAMPLING CONE WITH COATING - A mass spectrometer includes an ion source, which includes a coating or surface formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal.11-22-2012
20080272294Laser desorption - electrospray ion (ESI) source for mass spectrometers - An ion source is disclosed for forming multiply-charged analyte ions from a solid sample. A beam of pulsed radiation is directed onto a portion of the sample to desorb analyte molecules. A retaining structure holding a solvent volume is positioned proximate the sample. Desorbed analyte molecules contact a free surface of the solvent and pass into solution. The solution is then conveyed through an outlet passageway to an electrospray apparatus, which introduces a spray of charged solvent droplets into an ionization chamber.11-06-2008
20080265153METHOD OF COATING AN ELECTROSPRAY EMITTER - The present invention provides a method of coating an electrospray emitter with silver and then gold utilizing wet-coating processes. First, the electrospray emitter is immersed in a silver-containing liquid solution to coat the electrospray emitter in a layer of silver. Next, the silver-coated electrospray emitter is removed from the silver solution and rinsed with water. The silver-coated electrospray emitter is then annealed to stabilize the silver layer. Once the silver layer has been stabilized, the silver-coated electrospray emitter is immersed into a gold-containing liquid solution and a voltage is applied. This voltage serves to electrochemically deposit a gold layer onto the silver layer. The gold- and silver-coated electrospray emitter is then removed from the gold-containing liquid solution and rinsed with water and, preferably, with nitric acid.10-30-2008
20080265154MASS SPECTROMETER ION GUIDE PROVIDING AXIAL FIELD, AND METHOD - An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (U10-30-2008
20110006203MS/MS MASS SPECTROMETER - During a halt period of time when the introduction of ions is temporarily discontinued to change an objective ion to be selected by a first mass separator in the previous stage, a pulsed voltage having a polarity opposite to that of the ions remaining in a collision cell (01-13-2011
20110204223Mass Spectrometer - Problem: To provide a mass spectrometer wherein the door can be easily opened even when the door becomes stuck to a third wall surface.08-25-2011
20110220787CYCLING ELECTROSPRAY IONIZATION DEVICE - A cycling electrospray ionization device includes a driving mechanism and a nozzle. The nozzle is configured to sequentially form liquid droplets of an electrospray medium thereat, and is adapted to establish a traveling path with a receiving unit of a mass spectrometer such that when a potential difference is applied between the nozzle and the receiving unit to lade the liquid droplets with a plurality of electric charges for ionizing analytes to form ionized analytes, the charged droplets are forced to move toward the receiving unit along the traveling path. The nozzle defines a nozzle axis, and is driven by the driving mechanism to proceed with a cycling route about a cycling axis such that the nozzle axis tracks along the cycling route, and such that immediately after leaving the nozzle, the liquid droplets cooperate to form a substantially columnar plume with a cross section substantially surrounded by the cycling route.09-15-2011
20110220789Sample Component Trapping, Release, and Separation with Membrane Assemblies Interfaced to Electrospray Mass Spectrometry - The invention provides a method and apparatus for trapping, releasing and/or separating sample components in solution passing through a channel with or without packing material present by passing ion current through the channel driven by an electric field. A portion of the ion current comprises cation and/or anion species generated from second solution flows separated from the sample solution flow path by semipermeable membranes. Cation and/or Anion ion species generated in the second solution flow regions are transferred into the sample solution flow path through ion selective semipermeable membranes. Ion current moving along the sample solution flow path is controlled by varying the composition of the second solutions and/or changing the voltage between membrane sections for a given sample solution composition. The sample composition may also be varied separately or in parallel to enhance trapping, release and/or separation efficiency and range. The invention when interfaced to an Atmospheric Pressure Ion Source, that may include Electrospray Ionization, with mass spectrometric analysis enables independent control of the on-line sample separation process and the Atmospheric Pressure Ion Source or Electrospray ionization processes.09-15-2011
20110220788Apparatus for focusing and for storage of ions and for separation of pressure areas - An apparatus for focusing and for storage of ions and an apparatus for separation of a first pressure area from a second pressure area are disclosed, in particular for an analysis apparatus for ions. A particle beam device may have at least one of the abovementioned apparatuses. A container for holding ions and at least one multipole unit are provided. The multipole unit has a through-opening with a longitudinal axis as well as a multiplicity of electrodes. A first set of the electrodes is at a first radial distance from the longitudinal axis. A second set of the electrodes is in each case at a second radial distance from the longitudinal axis. The first radial distance is less than the second radial distance. Alternatively or additionally, the apparatus may have an elongated opening with a radial extent. The opening has a longitudinal extent which is greater than the radial extent.09-15-2011
20090101814CAPILLARY SEPARATED VAPORIZATION CHAMBER AND NOZZLE DEVICE AND METHOD - There is provided a capillary separated vaporization chamber and nozzle method and device for improved electron ionization liquid chromatography mass spectrometry of samples in a supersonic molecular beam. The device includes a vaporization chamber located upstream of a supersonic nozzle; a capillary separating the vaporization chamber and the supersonic nozzle, means for spray formation from sample in a flowing liquid; a vacuum system into which the supersonic nozzle induces supersonic expansion of the vaporized sample compounds and solvent vapor, for forming a supersonic molecular beam with vibrationally cold sample molecules and vaporized solvent; flythrough electron ionization ion source; mass analyzer; an ion detector and means for data processing of the resulting mass spectral information, for identifying and/or quantifying the chemical content of the sample.04-23-2009
20090001263ON-PROBE SAMPLE CLEANUP SYSTEM AND METHOD FOR MALDI ANALYSIS - A system and method for cleanup of biological samples from contaminants prior to spectroscopy analysis. The system includes a support configured to hold a sample including a liquid having at least one group of biological molecules with a surface of the support binding the molecules at a surface tension angle to the liquid of less than 180 degrees. The system includes an evaporator configured to evaporate liquid from the support, a solvent applicator configured to apply a solvent for dissolution of the contaminants in the sample, and a solvent removal device configured to remove applied solvent from the sample and thereby at least partially remove the contaminants.01-01-2009
20090242754Microchip and sample analysis method - The present invention provides a microchip and a sample analysis method in which mass analysis of a separated sample can be performed with high sensitivity without damaging resolution of a microchip. A microchip includes a channel formed on a substrate and sample collection portions which are formed along the channel, apart from the channel and are apart from each other.10-01-2009
20120104249MASS SPECTROMETER AND LIQUID-METAL ION SOURCE FOR A MASS SPECTROMETER OF THIS TYPE - The invention relates to a mass spectrometer comprising an ion source for producing a primary ion beam, which has a heatable ion emitter coated by a liquid metal layer essentially comprised of pure metallic Bismuth or of a low-melting-point alloy containing, in essence, Bismuth. A Bismuth ion mixed beam can be emitted by the ion emitter under the influence of an electric field. From the Bismuth ion mixed beam, one of a number of Bismuth ion types whose mass is a multiple of monatomic singly or multiply charged Bismuth ions Bi05-03-2012
20120104248Combined Ion Source for Electrospray and Atmospheric Pressure Chemical Ionization - A ion source for a mass spectrometer comprises: a capillary having a nozzle for emitting a nebulized fluid sample; an electrode of the capillary; a high voltage power supply; a second electrode disposed within or configurable to be disposed within a path of the nebulized fluid sample; and at least one switch for selecting application of an electrical potential provided by the high voltage power supply to either or both of the capillary electrode or the second electrode, wherein the capillary and capillary electrode are configurable so as to ionize the nebulized fluid sample by electrospray ionization and the second electrode is configurable so as to ionize the nebulized sample by atmospheric pressure chemical ionization.05-03-2012
20080315083Device and Method for Coupling Capillary Separation Methods and Mass Spectrometry - The present invention relates to capillaries which are at least partially sheathed with metal foil and to the use thereof in the coupling of methods such as HPLC, CE (capillary electrophoresis), CEC (capillary electrochromatography) or pCEC (pressurised CEC) to MS (mass spectrometry). The sheathing according to the invention with metal foil enables direct coupling of the capillaries to a mass spectrometer without using further adapters, such as spray needles or empty capillary parts.12-25-2008
20120104247Mass Spectrometer - A sample stage (05-03-2012
20120104246Dual Source Mass Spectrometry System - In or for a dual source mass spectrometer system (05-03-2012
20090256072MASS INDEPENDENT KINETIC ENERGY REDUCING INLET SYSTEM FOR VACUUM ENVIRONMENT - A particle inlet system comprises a first chamber having a limiting orifice for an incoming gas stream and a micrometer controlled expansion slit. Lateral components of the momentum of the particles are substantially cancelled due to symmetry of the configuration once the laminar flow converges at the expansion slit. The particles and flow into a second chamber, which is maintained at a lower pressure than the first chamber, and then moves into a third chamber including multipole guides for electromagnetically confining the particle. The vertical momentum of the particles descending through the center of the third chamber is minimized as an upward stream of gases reduces the downward momentum of the particles. The translational kinetic energy of the particles is near-zero irrespective of the mass of the particles at an exit opening of the third chamber, which may be advantageously employed to provide enhanced mass resolution in mass spectrometry.10-15-2009
20090256073Chemical Noise Reduction For Mass Spectrometry - In various aspects, the present teachings provide systems and methods for reducing chemical noise in a mass spectrometry instrument that use a neutral chemical reagent and one or more mass filters to reduce interfering chemical background ion signals that are generated by ionization sources of mass spectrometers. In various embodiments, the neutral chemical reagent belongs to the class of organic chemical species containing a disulfide functionality.10-15-2009
20100148062CHARGED-PARTICLE CONDENSING DEVICE - Ions and charged droplets move from the nozzle (06-17-2010
20090314936Sample target having sample support surface whose face is treated, production method thereof, and mass spectrometer using the sample target - In mass spectrometry which allows ionization of a sample without using any matrix, there are provided (i) a sample target which improves efficiency and stability of the ionization so as to be more practical and (ii) a production method thereof. The sample target includes, as a sample support surface, a surface which is used to support a sample in ionizing the sample on the basis of laser irradiation so as to perform mass spectrometry and which has a finely bumpy structure of an order ranging from nanometer to several dozen micrometer, wherein a face of the sample support surface is coated with metal. Further, the bumpy structure of the sample support surface is preferably arranged so that a plurality of concave portions are regularly formed so as to have an interval of not less than 1 nm and less than 30 μm. In the sample target, the concave portion has a trench shape, a lattice shape, or a cylindrical or prismatic shape. The sample target is produced in accordance with lithography.12-24-2009
20100258717ON-LINE AND OFF-LINE COUPLING OF ELECTROCHEMISTRY (EC) WITH LIQUID SAMPLE DESORPTION ELECTROSPRAY-MASS SPECTROMETRY (DESI-MS) - An apparatus for direct analysis of the redox products, or intermediates, of an electrochemical reaction by coupling an electrochemical cell to desorption electrospray ionization mass spectrometry.10-14-2010
20090078864Molecular sieves - A molecular sieve (03-26-2009
20100176293MASS SPECTROMETER - A cathode configuration for emission of electrons has a reaction zone connected to an entrance opening for the supply of neutral particles. The opening communicates with the cathode configuration for the ionization of the neutral particles and an ion extraction system communicates with the reaction zone. Ions from the extraction system are sent to a detection system and a mechanism for the evacuation of the mass spectrometer arrangement. The cathode configuration includes a field emission cathode with an emitter surface, wherein at a short distance from this emitter surface, an extraction grid is disposed for the extraction of electrons, which grid substantially covers the emitter surface. The emitter surface encompasses herein at least partially a hollow volume such that a tubular structure is formed.07-15-2010
20100193683CHROMATOGRAPHIC COLUMNS WITH INTEGRATED ELECTROSPRAY EMITTERS - A method of fabricating a chromatographic column and columns produced by such a method are disclosed. The method includes: (a) obtaining a tube comprising two open ends and a lumen with a diameter of 75 microns or less extending between the two open ends; (b) depositing a liquid silicate composition into the tube lumen at a first open end of the tube; (c) forming a porous ceramic material from the composition in the tube lumen at a location near the first open end such that a space is formed between the ceramic material and the open end that is substantially free of the ceramic material; and (d) forming a tapered emitter having an orifice diameter of less than 3 microns at the first open end.08-05-2010
20090242755LOW PRESSURE ELECTROSPRAY IONIZATION SYSTEM AND PROCESS FOR EFFECTIVE TRANSMISSION OF IONS - Systems and methods that provide up to complete transmission of ions between coupled stages with low effective ion losses. An “interfaceless” electrospray ionization system is further described that operates an electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer. Furthermore, chambers maintained at different pressures can allow for more optimal operating conditions for an electrospray emitter and an ion guide.10-01-2009
20120138789Phosphonium-Based Ionic Liquids and Uses - Phosphonium-based room temperature ionic liquids (“RTILs”) were prepared. They were used as matrices for Matrix-Assisted Laser Desorption Ionization (MALDI) mass spectrometry and also for preparing samples of dyes for analysis.06-07-2012
20120138790Miniature mass spectrometer system - A miniature mass spectrometer that may be coupled to an atmospheric pressure ionisation source is described. Ions pass through a small orifice from a region at atmospheric pressure or low vacuum, and undergo efficient collisional cooling as they transit a very short, differentially pumped ion guide. A narrow beam of low energy ions is passed through a small aperture and into a separate chamber containing the mass analyser.06-07-2012
20080277578Nanoporous substrates for the analytical methods - Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range.11-13-2008
20080277579MASS ANALYZING APPARATUS - The present invention relates to a mass analyzing apparatus, comprising a first metal electrode plate, a second metal electrode plate, an RF power supply, a reactant gas and a mass spectrometry. The second metal electrode plate is grounded. There is a gap between the first metal electrode plate and the second metal electrode plate. The RF power supply is electrically connected to the first metal electrode plate. Electric discharge is caused between the first metal electrode plate and the second metal electrode plate, so that the reactant gas becomes dissociation plasma. The dissociation plasma reacts with a gas analyte from a sample and then enters the mass spectrometry for a mass analysis. In addition, since the dissociation plasma is generated under low temperature and atmospheric pressure, the mass analyzing apparatus of the present invention is applicable for biological samples that need to be analyzed at a low temperature.11-13-2008
20090020696Membrane Interface Apparatus and Method for Analysis of Volatile Molecules by Mass Spectometry - The disclosed method and apparatus couple a membrane interface directly to a mass spectrometer at atmospheric pressure. The membrane may be in capillary or sheet form and allows the introduction of a liquid or gaseous sample to one side of the membrane while the other side of the membrane is bathed with a solution that can easily be used in an atmospheric pressure ionization source. Volatile molecules permeate through a suitable membrane such as poly-dimethyl silicone (PDMS), mix into the appropriate solvent, and are ionized. Because of the rules governing abstracts, this abstract should not be used in construing the claims.01-22-2009
20090020697Enhanced Resolution Mass Spectrometer and Mass Spectrometry Method - A mass spectrum is generated by a process in which, from a mass scan signal comprising original samples defining a peak, a subset of the original samples defining the peak is selected. One or more synthesized samples are synthesized from the subset of the original samples. The one or more synthesized samples provide a temporal resolution greater than the temporal resolution of the original samples. The one or more synthesized samples are summed with respective temporally-aligned accumulated samples to produce the mass spectrum. The accumulated samples are obtained from mass scan signals generated during respective previously-performed mass scan operations.01-22-2009
20110057099ION TRAPPING - This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.03-10-2011
20110127423Mass Spectrometer System - This invention describes an analytical system where a kinetic impact ionisation source is combined with an RF—only ion guide to form a mass spectrometer system for analysis of the elemental and chemical composition of exoatmospheric particles. The kinetic impact ionisation source may be used to transform a flux of particle debris into a beam of ions for analysis by a mass analyzer.06-02-2011
20090039253Gas monitoring apparatus - A gas monitoring apparatus includes a sample introducing portion, a measurement portion, an ionization portion, a mass analysis portion, a data processing portion and a display. The sample introducing portion introduces a sample gas including an object material to be measured. The measurement portion measures a concentration of a predetermined coexisting material, which coexists with the object material in the sample gas. The ionization portion ionizes the sample gas. The mass analysis portion analyzes mass of an ion produced by the ionization portion. The data processing portion analyzes signals detected by the mass analysis portion to calculate a concentration of the object material. And the display displays results of analysis conducted by the data processing portion. The data processing portion includes an adjustment portion which adjusts the concentration of the object material according to the concentration of the predetermined coexisting material.02-12-2009
20090039252MASS SPECTROMETER - A filament 02-12-2009
20090039251MASS SPECTROMETER - A side wall 02-12-2009
20080230693REVERSE-TAYLOR CONE IONIZATION SYSTEMS AND METHODS OF USE THEREOF - Ionization systems, methods of using ionization systems, ion source systems, methods of using ion source systems, and methods of ionization, are described herein.09-25-2008
20100301208Mass Spectrometer - A fault detection system for protecting a mass spectrometer from the effects of temperature extremes. The system comprises an ion block, a thermal source for providing thermal energy to the ion source block, a temperature sensor providing a reading for the temperature of the ion source block, a temperature regulation means for controlling the thermal source in dependence of the reading and a control system for monitoring the temperature change produced by the energy source.12-02-2010
20100301209DISCONTINUOUS ATMOSPHERIC PRESSURE INTERFACE - A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure.12-02-2010
20110127425Mass Spectrometer - An MS analysis is performed for each micro area within a specified mass analysis area on a sample. Based on the data obtained by this analysis, a distribution image of a specified m/z ratio of m/z range is created and displayed on a display screen (S06-02-2011
20110108727Method and System for Analysing a Dose Formulation of a Metered Dose Device - One aspect of the invention features a method of analyzing dose metered devices by spraying an aerosol from a metered dose device directly into a spray chamber of a mass spectrometer detector by firing a dose from a metered dose device, for example a pMDI, by depressing the pMDI in its actuator, which spraying step is optionally preceded by a step of priming the drug container of the metered dose device; ionizing the aerosol; and identifying and quantifying the content of the dose using the detector.05-12-2011
20110006202GAS SAMPLING DEVICE AND GAS ANALYZER EMPLOYING THE SAME - A gas sampling device has a high-vacuum tight chamber formed within its casing, which communicates with an ambient outside through an inlet hole for the gas flow to be ionised and the ambient downstream the ionisation chamber with an outlet hole for the ionised gas. A high-vacuum tight membrane separates the inlet hole from the ambient outside the chamber. The membrane has at least one nanohole formed therethrough with a diameter in the order of nanometers.01-13-2011
20110240851MASS SPECTROMETER - A radio-frequency ion guide (10-06-2011
20110240849Microengineered multipole rod assembly - A method of mounting rods in quadrupole, hexapole, octupole, and other multipole geometries is described. First and second dies are used to hold the rods in the required configuration with the plurality of rods extending through each of the two dies. A coupling arrangement is used to separate the first and second dies, and also prevents motion in the plane of the dies. The rods are seated and retained against individual supports and arranged circumferentially about an intended ion beam axis. The supports are desirably fabricated from silicon bonded to a glass substrate, a support for a first rod being electrically isolated from a support for a second adjacent rod.10-06-2011
20110042567Ionization Method and Ionization Apparatus - A sample solution containing a sample component is sprayed onto an atmosphere at atmospheric approximately pressure while being applied with electric charge from the tip of a nozzle (02-24-2011
20110042566CONDUCTIVE CONDUITS FOR CHEMICAL ANALYSES, AND METHODS FOR MAKING SUCH CONDUITS - A method for making a fluid-processing apparatus involves mixing a colloidal suspension with a matrix material, applying the mixture to a surface of a conduit, and curing the applied mixture to provide a conductive coating. A fluid-processing apparatus includes a conduit and a conductive layer adjacent to a surface of the conduit. The conductive layer includes graphite particles embedded in a matrix. The fluid-processing apparatus supports, for example, electrospray-ionization for mass spectrometry, capillary electrophoresis, or capillary electro-chromatography.02-24-2011
20110240850Microengineered Multipole Ion Guide - A microengineered multipole ion guide for use in miniature mass spectrometer systems is described. Exemplary methods of mounting rods in hexapole, octupole, and other multipole geometries are described. The rods forming the ion guide are supported in etched silicon structures defined in at least first and second substrates.10-06-2011
20110127422MULTI-BORE CAPILLARY FOR MASS SPECTROMETER - A mass spectrometer system an ion source configured to produce ions and a non-metallic capillary configured to receive at least a portion of the ions from the ion source. The capillary includes an elongated body and multiple bores traversing the elongated body in a longitudinal direction. The bores transport the received ions through the capillary toward a mass analyzer of the mass spectrometer system for detection.06-02-2011
20120228492UTILIZING GAS FLOWS IN MASS SPECTROMETERS - The invention relates to ions guided by gas flows in mass spectrometers, particularly in RF multipole systems, and to RF quadrupole mass filters and their operation with gas flows in tandem mass spectrometers. The invention provides a tandem mass spectrometer in which the RF quadrupole mass filter is operated at vacuum pressures in the medium vacuum pressure regime, utilizing a gas flow to drive the ions are through the mass filter. Vacuum pressures between 0.5 to 10 pascal are maintained in the mass filter. The mass filter may be enclosed by a narrow enclosure to guide the gas flow. The quadrupole mass filter may be followed by an RF multipole system, operated at the same vacuum pressure, serving as fragmentation cell to fragment the selected parent ions. The fragmentation cell may be enclosed by the same enclosure which already encloses the mass filter, so the ions may be driven by the same gas flow at the same vacuum pressure, greatly simplifying the required vacuum pumping system in tandem mass spectrometers. There are many other applications utilizing gas flows including supersonic gas jets in mass spectrometry.09-13-2012
20090078865APPARATUS AND SYSTEMS FOR PROCESSING SAMPLES FOR ANALYSIS VIA ION MOBILITY SPECTROMETRY - The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological samples, even non-volatile solids, via differential mobility spectrometry, without fragmentation of molecules. The invention also provides portable sample analysis systems that operate at ambient pressure. Systems of the invention may be used for high molecular weight species detection, for example, drinking water contaminants, pathogenic biological agents, bio-organic substances, non-biological material, peptides, proteins, oligonucleotides, polymers, bacteria, and hydrocarbons.03-26-2009
20100038533Ion Transfer Arrangement with Spatially Alternating DC and Viscous Ion Flow - A method of transporting gas and entrained ions between higher and lower pressure regions of a mass spectrometer comprises providing an ion transfer conduit 02-18-2010
20090218487MASS-SPECTROMETER INTERFACE HOUSING - An apparatus for performing chemical analyses includes a mass spectrometry module and an interface module that processes sample materials for delivery to the mass spectrometry module. The interface module includes a vessel having an opening to access a vessel chamber, a door to block the opening, a sealing member disposed between the door and the vessel, and an interlock. The interlock is actuated by the sealing member if the door is in the closed position and the sealing member is properly disposed between the door and the vessel to seal the vessel. The sealing member alternatively includes an indicator portion that is visible to an operator if the door is in the closed position and the sealing member is properly disposed.09-03-2009
20090218486Multipole ion guide interface for reduced background noise in mass spectrometry - Ions that are transported from an ion source to a mass spectrometer for mass analysis are often accompanied by background particles such as photons, neutral species, and cluster or aerosol ions which originate in the ion source. Background particles are also produced by scattering and neutralization of ions during collisions with background gas molecules in higher pressure regions with line-of-sight to the mass spectrometer detector. In either case, such background particles produce noise in mass spectra. Apparatus and methods are provided in which a multipole ion guide is configured to efficiently transport ions through multiple vacuum stages, while preventing background particles, produced both in the ion source and along the ion transport pathway, from reaching the detector, thereby improving signal-to-noise in mass spectra.09-03-2009
20100012835MS/MS MASS SPECTROMETER - The inside of the collision cell 01-21-2010
20100038532Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method - An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 02-18-2010
20090032702Method and Apparatus for Selectively Providing Electrons in an Ion Source - An electron source can selectively provide a first stream of electrons that travels in a direction along an imaginary line to a location remote from the electron source, or a second stream of electrons that travels in the direction along the line to the location. The electron source includes a first electron emitter for selectively emitting electrons for the first stream, and a second electron emitter for selectively emitting electrons for the second stream. A different aspect relates to a method for operating an apparatus having an electron source that includes first and second electron emitters. The method includes selectively producing a first stream of electrons that travels from the first electron emitter in a direction along an imaginary line to a location remote from the electron source, or a second stream of electrons that travels from the second electron emitter in the direction along the line to the location.02-05-2009
20100065739Method and System for Analysing a Dose Formulation of a Metered Dose Device - One aspect of the invention features a method of analyzing dose metered devices by spraying an aerosol from a metered dose device directly into a spray chamber of a mass spectrometer detector by firing a dose from a metered dose device, for example a pMDI, by depressing the pMDI in its actuator, which spraying step is optionally preceded by a step of priming the drug container of the metered dose device; ionizing the aerosol; and identifying and quantifying the content of the dose using the detector.03-18-2010
20120241604VACUUM MEASUREMENT DEVICE WITH ION SOURCE MOUNTED - A vacuum measurement device includes a grid (09-27-2012
20110101219LUMINOUS BODY, ELECTRON BEAM DETECTOR USING THE SAME, SCANNING ELECTRON MICROSCOPE, AND MASS ANALYSIS DEVICE - A light-emitting body of rapid speed of response and high light emission intensity, and an electron beam detector, scanning electron microscope and mass spectroscope using this are provided. In the light-emitting body 05-05-2011
20110062324MASS SPECTROMETER WITH BYPASS OF A FRAGMENTATION DEVICE - A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.03-17-2011
20120119082SAMPLING SYSTEM FOR USE WITH SURFACE IONIZATION SPECTROSCOPY - In various embodiments of the invention, a device permits more efficient collection and transmission of ions produced by the action of a carrier gas containing metastable neutral excited-state species into a mass spectrometer. In one embodiment of the invention, the device incorporates the source for ionization in combination with a jet separator to efficiently remove excess carrier gas while permitting ions to be more efficiently transferred into the vacuum chamber of the mass spectrometer. In an embodiment of the invention, improved collection of ions produced by the carrier gas containing metastable neutral excited-state species at greater distances from between the position of the analyte and the position of the mass spectrometer are enabled.05-17-2012
20090072135Micro Sample Heating Probe and Method of Producing the Same, and Analyzer Using the Micro Sample Heating Probe - An object of the present invention is to extract a micro foreign body of a few μm, which may cause a product defect of a device or the like, and to subject the foreign body to a mass analysis at a favorable S/N ratio without any contamination. A micro sample heating probe includes a sample holder made up of two members different in diameter, a supporting part, and a terminal part. The sample holder includes a heating mechanism only in a limited part, and just a region extremely close to the micro sample being an analysis target is heated locally. Therefore, even when a contaminated substance is attached to the probe, such substance is not heated, thereby preventing a noise from occurring, and enabling an analysis at a quite favorable S/N ratio.03-19-2009
20110253890FAIMS Having a Displaceable Electrode for On/Off Operation - A system for analyzing ions comprises: an ion source; a FAIMS cell comprising: (a) a gas inlet; (b) an outer electrode having a generally concave inner surface and comprising: (i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and (ii) an ion outlet; and (c) an inner electrode having a conduit therethrough and having a generally convex outer surface that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode for defining an ion separation region therebetween; and a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet, wherein the inner electrode is moveable between a first position and a second position, the first position facilitating movement of the ions through the ion separation region, the second position facilitating movement of the ions through the conduit.10-20-2011
20090001264Method for fractionating various components contained in a sample solution by liquid chromatograph mass spectrometer - A method for fractionating a sample solution includes the steps of setting a first mass spectrometry condition and mass range information; setting a second mass spectrometry condition and mass range information; executing a mass scan by the mass spectrum acquisition portion under the first mass spectrometry condition and obtaining first mass spectrum data; extracting first chromatogram data from the first mass spectrum data based on the first mass range information; executing a mass scan by the mass spectrum acquisition portion under the second mass spectrometry condition to obtain second mass spectrum data; extracting second chromatogram data from the second mass spectrum data based on the second mass range information; switching the first and second spectrometry conditions and repeating the mass scan cyclically; adding the first and second chromatograph data to obtain a chromatogram data; and operating the fraction collector based on the chromatogram data.01-01-2009
20090212210Mass spectrometer system - This invention describes a vacuum interface for a mass spectrometer system formed from a diverging nozzle. The vacuum interface may be used to transfer a beam of ions from an atmospheric pressure ionisation source into a vacuum chamber for analysis by a mass analyser.08-27-2009
20110174968CHARGED PARTICLE ANALYZER - An ion entrance opening (07-21-2011
20090114815PLASMA ELECTRON FLOOD FOR ION BEAM IMPLANTER - A plasma electron flood system, comprising a housing configured to contain a gas, and comprising an elongated extraction slit, and a cathode and a plurality of anodes residing therein and wherein the elongated extraction slit is in direct communication with an ion implanter, wherein the cathode emits electrons that are drawn to the plurality of anodes through a potential difference therebetween, wherein the electrons are released through the elongated extraction slit as an electron band for use in neutralizing a ribbon ion beam traveling within the ion implanter.05-07-2009
20090050801Confining/focusing vortex flow transmission structure, mass spectrometry systems, and methods of transmitting particles, droplets, and ions - Briefly described, embodiments of the present disclosure include: confining/focusing vortex flow transmission structures, mass spectrometry systems including a confining/focusing vortex flow transmission structure, methods of using the confining/focusing vortex flow transmission structure, methods of using mass spectrometry system, methods of transmitting droplets and ions, methods of evaporating droplets and desolvating ions, and the like.02-26-2009
20110174970PROCESS - The present invention relates to a process for fabricating a quadrupole mass spectrometer (QMS) component, to a monolithic quadrupole mass spectrometer or a component thereof, to a quadrupole mass filter (QMF) or quadrupole ion trap (QIT) capable of generating a hyperbolic electric field and to a modular quadrupole mass spectrometer (QMS) assembly.07-21-2011
20100320379DEVICES AND SYSTEMS INCLUDING A BOOST DEVICE - A device for mass spectroscopy comprising a chamber configured to provide an atomization source, a boost device configured to provide radio frequency energy to the chamber, and a mass analyzer in fluid communication with the chamber and configured to separate species based on mass-to-charge ratios is disclosed. In certain examples, a boost device may be used with a flame or plasma to provide additional energy to a flame or plasma to enhance desolvation, atomization, and/or ionization.12-23-2010
20110062325Quadropole Mass Spectrometer - If a scanning rate of a mass scanning is set to be high, the amount of change in an applied voltage between a time of an incidence of a certain ion into a quadrupole mass filter and a time of an emission of the ion therefrom increases. This leads to a change in the condition of a passage of ions, causing the amount of ions to decrease and thereby deteriorating detection sensitivity. In order to avoid this problem, according to the present invention, the values of direct current voltage U and an amplitude V of radio-frequency voltage, both voltages being applied to rod electrodes during a mass scanning, are respectively determined so that a voltage ratio U/V of the voltage U to the amplitude V becomes smaller as the scanning rate becomes higher. Accordingly, in a stability diagram based on the Mathieu equation, the inclination of line L indicating the change in the applied voltage during the mass scanning becomes gradual and the amount of ions passing through the quadrupole mass filter increases particularly when the mass is high.03-17-2011
20120126114Magnetic Sector Mass Spectrometry Based Multi-Parametric Particle Analyzer - An analytical instrument has a sample introduction system for generating a stream of particles from a sample and an ionization system for receiving the particles. The ionization system is operable to atomize the particles received from the sample introduction system and ionize atoms from the atomized particles. The instrument has an ion pretreatment system and a magnetic sector mass analyzer comprising an array detector. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The mass analyzer is adapted to detect a transient signal of at least one element from individual particles from said stream by performing mass analysis on the ions from the atomized particles. The magnetic sector mass analyzer is adapted determine an amount of said at least one element from an individual particle using the transient signal detected during mass analysis of the ions from said individual particle.05-24-2012
20110133077Solid-Phase Extraction (SPE) Tips and Methods of Use - Methods and systems for extraction of analytes from samples for analysis using mass spectrometers are described herein.06-09-2011
20110253891MASS SPECTROMETER - A mass spectrometer having a resolution improved by introducing ions into a mass spectrometry part with a high efficiency is provided with a small-sized, simple configuration. The mass spectrometer includes an opening/closing mechanism provided between a sample introducing piping part for introducing a sample into the mass spectrometry part and the mass spectrometry part to conduct gas introduction intermittently and control sample passage. The mass spectrometer further includes a pump mechanism to evacuate a high pressure side of the sample introducing piping part, that is, an opposite side of the opening/closing mechanism to the mass spectrometry part to have a pressure in a range of 100 to 10,000 Pa.10-20-2011
20110168884ION COLLECTING DEVICE FOR ION MOBILITY SPECTROMETER AND ION MOBILITY SPECTROMETER - The present invention provides an ion collection device for an ion mobility spectrometer and an ion mobility spectrometer. The ion collection device comprises: an aperture grid for restraining influence of ion drift movement in a drift region on ion collection; and a first electrode disposed at a downstream side of the aperture grid in an ion drift direction, the first electrode is mechanically and electrically coupled with the aperture grid. With the above configuration, the aperture grid and the first electrode are at the same electric potential, and form a focusing electrical field with an ion collection part. Therefore, ions entering the collection region will not scatter into a shield cover.07-14-2011
20110095181SYSTEMS, METHODS, AND APPARATUS OF A LOW CONDUCTANCE SILICON MICRO-LEAK FOR MASS SPECTROMETER INLET - Systems, methods and apparatus are provided through which in some embodiments a mass spectrometer micro-leak includes a number of channels fabricated by semiconductor processing tools and that includes a number of inlet holes that provide access to the channels.04-28-2011
20110174969SYSTEM AND METHOD FOR REPLACING AN ION SOURCE IN A MASS SPECTROMETER - A method of replacing an ion source in a mass spectrometer (MS) system is provided, where the ion source includes an ionization volume, at least one ionizing element and at least one focusing element, and where the mass MS system includes the ion source, a vacuum chamber that houses the ion source, and an interlock chamber. The method includes opening a valve between the interlock chamber and the vacuum chamber, moving the ion source into the interlock chamber through the opened valve and closing the valve, and removing the ion source from the interlock chamber. The ion source may further include means for plugging into a docking station in substantially one action, where the docking station provides sufficient electrical connection, upon plugging with the ion source, for operation of the ion source.07-21-2011
20110186732Mass Spectrometer - A technique for improving the efficiency of injecting ions into the electrode unit of a funnel structure having high ion-transport efficiency is provided to improve the overall ion-transport efficiency. From an ionization chamber 08-04-2011
20100025576VAPOR DELIVERY SYSTEM USEFUL WITH ION SOURCES AND VAPORIZER FOR USE IN SUCH SYSTEM - Vapor delivery systems and methods that control the heating and flow of vapors from solid feed material, especially material that comprises cluster molecules for semiconductor manufacture. The systems and methods safely and effectively conduct the vapor to a point of utilization, especially to an ion source for ion implantation. Ion beam implantation is shown employing ions from the cluster materials. The vapor delivery system includes reactive gas cleaning of the ion source, control systems and protocols, wide dynamic range flow-control systems and vaporizer selections that are efficient and safe. Borane, decarborane, carboranes, carbon clusters and other large molecules are vaporized for ion implantation. Such systems are shown cooperating with novel vaporizers, ion sources, and reactive cleaning systems.02-04-2010
20100065740ION TRAP MASS SPECTROMTER - While applying a square wave voltage to the ion electrode (03-18-2010
20090045333Electrospray emitter and method of using same - The present invention relates to electrospray emitters that have a rigid substrate layer, a second layer, a channel formed in one of the rigid substrate layer and an exit orifice in flow communication with the channel. The second layer is attached to the first layer. The exit orifice is capable of holding an electric charge. The electrospray emitter may be used with such devices as a mass spectrometer, a colloidal thruster or an ion mobility device. Additionally, it may be used to coat a surface.02-19-2009
20090057552Mass Spectrometer Equipped With MALDI Ion Source and Sample Plate for MALDI Ion Source - A mass spectrometer is equipped with a MAILDI ion source facilitating both individual management of sample plates and mass calibration based on information about distortion in the sample plates. Also, sample plates adapted to be used in the MALDI ion source are provided. Identification information about each sample plate and information about distortion, i.e., topography, in the surface of the sample plate are engraved on the surface of the sample plate. These sets of information are also registered as an electronic file. During measurement, these sets of information are read by observation means and used for individual management of sample plates and mass calibration of mass spectra.03-05-2009
20120037799ION DETECTOR - By detecting water clusters in expiration with high sensitivity, prevention of drink-driving and prevention of drowsy driving are performed. Also, device operation is performed in a non-contact manner. Problem: an effective method for prevention of drink-driving and prevention of drowsy driving for drivers has not been present. Effect: expiration can be sensed in a spatially-restricted place.02-16-2012
20080272292System and Method for Grouping Precursor and Fragment Ions Using Selected Ion Chromatograms - LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions arc grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After initial groupings are determined based on retention time, ion peak shapes are compared to determine whether ions should be excluded. Ions having peak shapes not matching other ions, or alternatively a reference peak shape, are excluded from the group.11-06-2008
20120205536MS/MS MASS SPECTROMETER - The gas conductance on the ion injection side of a collision cell is made larger than the gas conductance on the ion exit side by providing two ion injection apertures 08-16-2012
20120001067DIFFERENTIAL MOBILITY ANALYZER, PARTICLE MEASURING SYSTEM, AND PARTICLE SORTING SYSTEM - In order to provide a differential mobility analyzer and the like that allows (i) easy increase of an upper limit of particle size of charged particle which can be classified and (ii) analysis of charged particles whose particle size is variable, a DMA (Differential Mobility Analyzer) includes: a classification tank in which an inlet electrode having an inlet slit, an intermediate electrode having a slit, and an outlet electrode having an outlet slit are arranged in sequence in such a manner that adjacent electrodes are disposed opposing each other at predetermined intervals; a gas supply section supplying the classification tank with sheath gas; and a voltage generator applying a predetermined voltage between the electrodes disposed opposing each other, the classification tank including a first classification section and a second classification section each formed by the electrodes disposed opposing each other, and the gas supply section controlling a flow rate of the sheath gas to be supplied to the classification tank individually per first classification section and second classification section.01-05-2012
20120056087PORTABLE QUADRUPOLE ION TRAP MASS SPECTROMETER - A portable quadrupole ion trap mass spectrometer includes an electron emission source, an ion trap including a ring electrode and first and second end cap electrodes arranged opposite sides of the ring electrode, and an ion detector for detecting an amount of ions discharged from the ion trap. The first end cap electrode includes a first aperture through which the electrons emitted by the electron source enter the ion trap, and the second end cap electrode includes a second aperture through which ions are discharged the ion trap. A first electron multiplier is disposed in the first aperture of the first end cap electrode and multiplies an amount of the electrons and input to the ion trap. An ion detector detects an amount of the ions discharged from the ion trap.03-08-2012
20120012745Extraction and Detection System and Method - An apparatus, system and method for the continuous flow extraction, collection and analysis of small amounts of energetic substance/s and their reacted/unreacted residue/s in real time are provided. The apparatus includes an agitator that generates a particulate material from a surface. A vacuum gathers particulate material which is provided to a mixing module. The mixing module creates a supercritical matrix containing the particulate matter. A separator separates and removes waste in the supercritical matrix from the supercritical matrix. Concentrated particulate material from the supercritical matrix is provided to a mass spectrometer for analysis and detection of a target material in proximate real-time. In one embodiment, the separator provides the supercritical matrix to a tube arm. The tube arm is heated to reduce solvent in the supercritical matrix. A collector in the tube arm concentrates particulate material, which is volatilized by a laser. Volatilized particulate material is provided to the mass spectrometer. In another embodiment, the separator provides the supercritical matrix to an electrospray or APCI module whose output is provided direct to the mass spectrometer.01-19-2012
20110049359ACTIVE PARTICLE TRAPPING FOR PROCESS CONTROL - A particle isolation system includes a semiconductor process chamber; at least one member within the semiconductor process chamber wherein the member has at least a first position and a second position; and at least one isolation compartment having a plurality of walls, the isolation compartment defined by the plurality of walls, at least one of the plurality of walls of the isolation compartment defining at least one opening wherein the member in the first position permits particles to enter the isolation compartment from the semiconductor process chamber through the opening, and wherein the member in the second position substantially encloses the isolation compartment thereby substantially retaining the particles in the isolation compartment and substantially limiting movement of the particles between the semiconductor process chamber and the isolation compartment through the opening. An ion implant system is also provided.03-03-2011
20110089320DIRECT INJECTION NEBULIZER - A direct injection nebulizing system includes a capillary and an injector. The capillary is insertable into the injector, and the injector is insertable into an injector holder. The injector includes an opening and a portion of the capillary extends beyond the opening of the injector.04-21-2011
20110127424COLLISION-INDUCED DECOMPOSITION OF IONS IN RF ION TRAPS - In an RF ion trap, analyte ions are fragmented by applying a moderately high RF storage voltage to the trap. The ions are then excited via dipolar excitation, and after a short time, the ions are forced into a resting state, again using dipolar excitation. The RF storage voltage is then rapidly reduced to a low value thereby making it possible to store small fragment ions produced by ergodic decompositions that occur subsequent to the reduction of the RF storage voltage.06-02-2011
20120126113ANALYZER CONSTITUTED BY GAS CHROMATOGRAPH COMBINED WITH INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER - The invention provides a new GC/ICP-MS capable of preventing carbon deposition caused by the analysis sample or its solvent. With a GC/ICP-MS, it is effective to introduce oxygen continuously or during a specific period to the part where argon or other makeup gas is introduced to the ICP-MS, and this is achieved by introducing oxygen in air into the gas supply line using an oxygen permeable tube or oxygen permeable membrane. A selector valve is used to introduce permeated oxygen to the aforementioned gas supply line only during a desired period.05-24-2012
20120132800VACUUM SYSTEM - The invention provides a vacuum system (05-31-2012
20120132799Mass Spectrometer - A samples stage (05-31-2012
20110180706Atmospheric Pressure Solids Analysis Probe Assembly - An atmospheric pressure ion source probe assembly (07-28-2011
20120132798PRECONCENTRATOR FOR ANALYSIS INSTRUMENTS - An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path.05-31-2012
20090057551LOW PRESSURE ELECTROSPRAY IONIZATION SYSTEM AND PROCESS FOR EFFECTIVE TRANSMISSION OF IONS - A system and method are disclosed that provide up to complete transmission of ions between coupled stages with low effective ion losses. A novel “interfaceless” electrospray ionization system is further described that operates the electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer.03-05-2009
20120248306Ion Detecting Device - The present invention provides a small-sized ion detecting device that quickly and simply performs mass analysis under atmospheric pressure. Accordingly, electrodes are arranged and held in the ion detecting device so as to be able to detect water clusters in ambient air with a high sensitivity. Thereby, ions can be detected even in a spatially-restricted place.10-04-2012
20120312984Mass Spectrometry for Gas Analysis with a One-Stage Charged Particle Deflector Lens Between a Charged Particle Source and a Charged Particle Analyzer Both Offset from a Central Axis of the Deflector Lens - Apparatus, methods and systems are provided to inhibit a sightline from a charged particle source to an analyzer and for changing a baseline offset of an output spectrum of an analyzer. A supply of charged particles is directed through a hollow body of a deflector lens that is positioned relative to a charged particle source and an analyzer. A flow path along a preferred flow path through a deflector lens permits passage of the ions from the source to the detector while inhibiting a sightline from the detector to the source in a direction parallel to the central longitudinal axis of the deflector lens.12-13-2012
20120248304Ion Guide with Improved Gas Dynamics and Combined Noise Reduction Device - A mass spectrometry system arrangement includes a curved ion guide, where the curve of the ion guide is positioned such that a portion of the ion optics are visible from at the ion guide entrance, e.g. line of sight or z-axis. There are four electrodes parallel with each other and the central curved axis. Each electrode is equally radially spaced from the curved central axis. For each cross section of the ion guide, the central curved axis being positioned at the origin, the curved electrodes being radially positioned at 45°, 135°, 225°, and 315°. Depending upon the system, a blocking device is positioned external to the ion guide but within the “line of sight” or positioned tangential to the rising section of the bent ion guide.10-04-2012
20120223225Integrated Electrospray Ionization Emitter and Detection Cell for Parallel Measurements by Fluorescence and Mass Spectrometry - An integrated mass spectrometer electrospray emitter and fluorescence detector allows improved volumetric measurements of separate components from a liquid chromatography column by improving correlation between the readings of these instruments and reducing dead volume and sample size requirements.09-06-2012
20100025575Electrospray device - An electrospray device includes an electrospray emitter adapted to receive electrospray fluid; an extractor plate spaced from the electrospray emitter and having at least one aperature; and a power supply for applying a first voltage between the extractor plate and emitter for generating at least one Taylor cone emission through the aperature to create an electrospray plume from the electrospray fluid, the extractor plate as well as accelerator and shaping plates may include a porous, conductive medium for transporting and storing excess, accumulated electrospray fluid away from the aperature.02-04-2010
20080296493Enriichment tube for sampling ions - An improved ion sampling tube designed to increase the amount of current delivered into the vacuum system of a mass spectrometer or other gas-phase ion or particle detectors or collectors. A device and method is disclosed that utilizes a tube with a high flow of ion entrained gas passing through the said tube. Said ions are directed from the tubular gas flow through an ion selective aperture and into an adjacent region and subsequently directed into a lower pressure region for detection or collection. The method is useful for enhancing the detection of analytes in solutions that are either nebulized or electrosprayed, and analytes present in gases. The method is also useful for isolating ionic species from the ion source from neutral gases and particles that may interfere or interact with analyte species. The method also decouples the high flow of the atmospheric pressure ion source from the low flow ion transmission into vacuum.12-04-2008
20080296492METHODS AND APPARATUS FOR PERFORMING CHROMATOGRAPHY AND MASS SPECTROSCOPY WITH SUPERCRITICAL FLUID SAMPLES - Embodiments of the present invention are directed to devices and methods for receiving NSC Fluids having at least one analyte from a chromatograph and directing analyte ions into the vacuum regions of a mass spectrometer. The device has a housing having at least one wall defining a chamber, sample inlet, an ionization media inlet and an outlet. The sample inlet has a position in communication with a chromatograph receiving a NSC Fluid. The sample inlet receives the NSC Fluid and directs the NSC Fluid into the chamber to form a sample jet of NSC Fluid. The ionization media inlet is placed in fluid communication with a source of ionization media and directs the ionization media into the chamber and the sample jet to create analyte ions. The analyte ions are received in the mass spectrometer vacuum region orifice.12-04-2008
20110036980MULTI-PRESSURE STAGE MASS SPECTROMETER AND METHODS - A mass spectrometer includes a plurality of guide stages for guiding ions between an ion source and an ion detector along a guide axis. Each of the guide stages is contained within one of a plurality of adjacent chambers. Pressure in each of the plurality of chambers is reduced downstream along the guide axis to guide ions along the axis. Each guide stage may further include a plurality of guide rods for producing a containment filed for containing ions about the guide axis, as they are guided to the detector.02-17-2011
20110036979SYSTEM TO REDUCE THE PRESSURE DROP IN A DIFFERENTIAL MOBILITY ANALYZER - System to reduce the pressure drop in a Vienna-type differential mobility analyzer (DMA). It is built to favor the flow axilsymmetry, with no restrictions to avoid strong pressure drops and high pumping capacities. It comprises an electrical isolator, a metallic cone to stabilize the flow, all in one instrument covering a size range of 1 to 600 nm. The electrical isolator is capable of a potential difference of up to 14 kV. It can be used to measure ions and particles in the size range already mentioned with resolutions up to 12.02-17-2011
20120298860MEANS AND METHOD FOR FIELD ASYMMETRIC ION MOBILITY SPECTROMETRY COMBINED WITH MASS SPECTROMETRY - Analyte ions are analyzed first by field asymmetric ion mobility spectrometry (FAIMS) before being analyzed by a mass analyzer. Analyte ions are produced at near atmospheric pressure and transferred via a dielectric capillary into the vacuum system of the mass analyzer. While passing through the capillary, the ions are analyzed by FAIMS via electrodes on the interior wall of the capillary. Improved ion transmission is achieved by providing smooth geometric transitions between the channel in FAIMS analyzer and the channel in the remainder of the capillary.11-29-2012
20120267525GAS ANALYZER - The present invention is directed to a gas analyzer that hardly generates noise peaks and facilitates reading of a molecular peak, even when a low-molecular-weight alkane is an analysis target. The analyzer analyzes an alkane of the carbon number 1 through 12 contained in a sample gas as an analysis target. The analyzed includes an ionization module for ionizing the sample gas by thermoelectrons having energy of 10 through 30 eV, an ion extraction electrode for extracting ions from the ionization module, a quadrupole module for selectively passing the ions extracted from the ionization module by the ion extraction electrode, through the quadrupole module, and an ion detection module for detecting the ions passed through the quadrupole module.10-25-2012
20120318973ATMOSPHERIC PRESSURE IONIZATION APPARATUS AND METHOD - An atmospheric pressure ionization apparatus includes a chamber, an ion inlet structure, an electrode, a sample emitter, and a gas passage. The ion inlet structure includes a sampling orifice. The electrode includes an electrode bore. An ionization region is defined between the ion inlet structure and the electrode. The flared structure is coaxially disposed about the ion inlet structure, and extends along an outward direction that includes a radial component relative to the sampling axis. The sample emitter is oriented at an angle to the sampling axis for directing a sample stream toward the ionization region. The gas passage directs a stream of gas from a gas source to the chamber. The flared structure and the wall cooperatively form an outward-directed portion of the gas passage that extends annularly about the sampling axis and along the outward direction. The gas flows through the outward-directed portion, around the flared structure, and toward the ionization region and the electrode bore.12-20-2012
20100059674METHOD AND APPARATUS OF LIQUID SAMPLE-DESORPTION ELECTROSPRAY IONIZATION-MASS SPECROMETRY (LS-DESI-MS) - An apparatus and method for direct analysis of continuous-flow liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS) including a sample stage that is adapted to receive a liquid sample and a nebulizing ionizer that is configured to generate a charged, nebulized solvent and thereby desorb at least a portion of the liquid sample from the sample stage.03-11-2010
20110248162Parallel Mass Analysis - A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.10-13-2011
20120280122QUADRUPOLE MASS SPECTROMETER - A quadrupole mass spectrometer for use in analyzing gas components in a test piece is made in a constitution in which resistance heating of a grid is materialized, and in which a high-accuracy analysis of the gas components is possible at a low cost while preventing the sensitivity from lowering. A quadrupole mass spectrometer is provided with a sensor section which can be detachably fitted to the test piece. Supposing that the direction of fitting the sensor section to the test piece is in an upward direction, the sensor section is provided with: a predetermined shape of supporting body which is provided at a lower end of the sensor section; an ion source which is provided on the supporting body and which has a filament and a grid for ionizing the gas; a quadrupole section which is provided on the ion source and in which four columnar electrodes are disposed at a predetermined circumferential distance from one another; and an ion detection section which is disposed on the quadrupole section and which collects predetermined ions that have passed through the quadrupole section by applying DC and AC voltages between opposite electrodes.11-08-2012
20130015349LENS FREE COLLISION CELL WITH IMPROVED EFFICIENCY - An ion collision cell is fabricated by four semi-circular profile elements, all of which are attach to the same reference plate. Consequently, all four elements remain aligned to the same reference plate. The four elements form a semi-circular channel with a semi-circular quad electrodes. The quad electrodes receive electrical potential to form the field required to focus and maintain the ions at the center of the channel. semi-circular insulators are provided on all sides of the channel so as to seal the channel over its length from the interior of the mass spectrometer.01-17-2013
20130015348CURVED HEATED ION TRANSFER OPTICS - An ion optics assembly is formed by four quarter-circular profile elements, all of which are attach to the same reference plate. Consequently, all four elements remain aligned to the same reference plate. The four elements form a quarter-circular channel with quarter-circular quad electrodes. The quad electrodes receive electrical potential to form the field required to focus and maintain the ions at the center of the channel. Quarter-circular insulators are provided on all sides of the channel so as to seal the channel over its length from the interior of the mass spectrometer. A heater is provided at the entrance to the ion transfer optics, to prevent accumulation of ions on the poles. A thermal break is provided in the quad, so as to enable maintaining the front of the quad heated and the rest of the quad cooler.01-17-2013
20130015347MASS SPECTROMETER WITH PRECISELY ALIGNED ION OPTIC ASSEMBLIES - A mass spectrometer has a manifold and at least one ion optical assembly that is composed of a support and electrodes attached to the support. The support is aligned to at least one reference surface machined integrally with the manifold such that the number of interfaces between the reference surface of the manifold and the electrodes is minimized. With such a design the positional and/or alignment precision of ion optical assemblies in a mass spectrometer can be improved.01-17-2013
20120091335SURFACE SAMPLING SYSTEMS FOR COLLECTING VOLATILIZED SAMPLES - The sampling system includes a transfer tube and a sampling head configured to volatilize a sample from a test surface. The transfer tube has an inlet end for receiving a volatized sample into an interior of the transfer tube and an outlet end for directing the volatized sample from the interior of the transfer tube. The sampling head is coupled to the inlet end of the transfer tube and has a volatilized sample receiving area defined by a distal end that is configured to be brought into contact with the test surface and an opening in the sampling head that is in fluid communication with the inlet end of the transfer tube. The distal end of the sampling head includes a porous metallic membrane.04-19-2012
20080283742Mass Spectrometer - The present invention provides a mass spectrometer having an ion lens capable of transporting an ion having a large mass to charge ratio with a high level of ion-passing efficiency even under a low-vacuum atmosphere. In conventional atmospheric pressure ionization mass spectrometers or similar mass spectrometers, applying an excessively high voltage to the ion lens undesirably causes an electric discharge. Therefore, the passing efficiency for an ion having a large mass to charge ratio cannot be adequately improved, which leads to a poor detection sensitivity. To solve this problem, the mass spectrometer according to the present invention includes a voltage controller 11-20-2008
20130009055SYSTEM OF ELECTROSPRAY ION GENERATOR - This invention relates to an analytical instrument field, specifically an instrument for pharmaceutical micromolecular and biological macromolecular ion generation. By this invention, through a hollow capillary emission needle and an emission needle bracket, the emission needle bracket forms a forward moving laminar flow gas surrounding the emission needles, eliminating the capillary counter-flow effect outside the capillary for liquid flowing out of the hollow capillary emission needle and pushing liquid forward; and vacuum lead-in capillary whose entrance is a specially designed arc mechanism, makes zero air flow speed in any direction, and the entrance happens to be the exit of the hollow capillary emission needle so as to ensure steady Taylor cone on the tip edge and ultimately obtains steady ion flow within a large flow range. This invention has advantages of steady ion emission and high ion transmission efficiency, and can be widely applied in the ion source preparation.01-10-2013
20130020483APPARATUS FOR PHOTOIONIZATION OF AN ANALYTE IN AN ELUENT OF A CHROMATOGRAPHY COLUMN - Described is an apparatus for photoionization of an analyte in an eluent of a chromatography column. The apparatus includes a laser to generate a beam of optical radiation, a mass spectrometer and one or more optical components to receive the beam and to generate a concentrated region of optical radiation near an orifice of the mass spectrometer so that an analyte in the vapor phase of the eluent is ionized. Alternatively, the apparatus includes a laser driven light source, a mass spectrometer and an optical imaging system. The laser driven light source includes an optical enclosure having an ionizable medium, an ignition source and a laser for pumping optical radiation into the ionizable medium. The optical imaging system generates an image of the pumped region of the ionized medium proximate to the orifice of the mass spectrometer to thereby photoionize an analyte in the vapor phase of the eluent.01-24-2013
20080251716SYSTEM FOR OPTIMIZING ALIGNMENT OF LASER BEAM WITH SELECTED POINTS ON SAMPLES IN MALDI MASS SPECTROMETER - A mass spectrometry apparatus uses image processing of output signals of a camera in a mass spectrometer to provide feedback for directing the laser. The present invention provides for the determination of where samples have actually been deposited on a plate, and for the selection of different points for each sample, based on its structure, at which to aim a laser, during the cycle period of the mass spectrometer. Such feedback information increases the likelihood that the laser impinges samples and provides useful data.10-16-2008
20080251715INTRODUCTION OF IONS INTO A MAGNETIC FIELD - In a mass spectrometer that uses a space-restricted magnetic field, such as an ion cyclotron resonance mass spectrometer, ions with a wide mass range generated in an ion supply located outside the magnetic field are transported in the direction of the magnetic field lines to an ion storage device located inside the magnetic field without losing ions by guiding the ions through the region in which the magnetic field strength increases with a special ion guide. This ion guide consists of an arrangement of coaxial ring diaphragms which are alternately supplied with the phases of an RF voltage. In an alternative embodiment, the ion guide uses two wires wound in a double helix where each wire is supplied with one phase of a two-phase RF voltage.10-16-2008
20080251714Resolution improvement in the coupling of planar differential mobility analyzers with mass spectrometers or other analyzers and detectors - Prior work on differential mobility analysis (DMA) combined with mass spectrometry (MS) has shown how to couple the output of the DMA with the inlet of an atmospheric pressure ionization mass spectrometer (APCI-MS). However, the conventional ion inlet to an APCI-MS is a round orifice, while conventional DMA geometries make use of elongated slits. The coupling of two systems with such different symmetries limits considerably the resolutions attainable by the DMA in a DMA-MS combination below the value of the DMA alone. The purpose of this invention is to overcome this limitation in the case of a parallel plate DMA. One solution involves use of an elongated rather than a circular MS sampling hole, with the long dimension of the MS inlet hole aligned with that of the DMA slit. Another involves use of a more elongated orifice in the DMA exit and a more circular hole on the MS inlet, the two being connected either through a short transfer conduit or through an ion guide. The DMAs described can also be coupled profitably to detectors and analyzers other than mass spectrometers.10-16-2008
20130140454ION LENS FOR REDUCING CONTAMINANT EFFECTS IN AN ION GUIDE OF A MASS SPECTROMETER - An ion lens for reducing contaminant effects in an ion guide of a mass spectrometer is provided. The ion lens comprises a structural member comprising an orifice of a given radius, the structural member for supporting the ion lens at an exit region of the ion guide. The ion lens further comprises a conical member extending from the structural member, the conical member being hollow and comprising a given cone angle, and a base of the given radius, a perimeter of the base connected to a perimeter of the orifice. The conical member further comprises an aperture through an apex of the conical member, the aperture for receiving ions there through from the ion guide.06-06-2013
20130140456CURTAIN GAS FILTER FOR HIGH-FLUX ION SOURCES - A curtain-gas filter for a mass- or mobility-spectrometer that bars gases or vapors of a high-flux atmospheric pressure ion source, as we ions of high mobility and charged droplets, from entering an evacuated mass spectrometer or a mobility spectrometer that is at a lower pressure than the main filter volume of the curtain-gas filter. A portion of the ion-source buffer gas in the ion-source plume is sucked through an ion-source buffer gas inlet into the main filter volume of the curtain-gas filter, from where this ion-source gas is exhausted after a properly shaped electric field has pushed a large portion of the embedded ions into an externally provided stream of a clean buffer gas, which is sucked through a passage into a mass- or mobility-spectrometer that is at a lower pressure.06-06-2013
20130175440RADIO FREQUENCY (RF) ION GUIDE FOR IMPROVED PERFORMANCE IN MASS SPECTROMETERS - Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range.07-11-2013
20130175441ION GUIDE AND ELECTRODE FOR ITS ASSEMBLY - An ion guide that transports ions from an ion source at generally a high-pressure level to a mass analyzer at generally a low-pressure level has a plurality of identical electrodes fabricated with protruding elements that forming an ion tunnel or an ion funnel, when the electrodes are assembled around a common longitudinal axis. The protruding elements allow the generation of the radio frequency field necessary to radially confine ions. Each electrode may be machined from a solid block of conductive material, such as metal. The disclosed arrangement greatly simplifies the manufacturing process, reducing cost, and improving robustness and reliability of the ion guide itself.07-11-2013
20130175442INDUCTIVELY COUPLED PLASMA MS/MS MASS ANALYZER - An inductively coupled plasma MS/MS mass analyzer (ICP-MS/MS) may include a first vacuum chamber which draws plasma containing an ionized sample into vacuum, a second vacuum chamber which includes a device or means which extracts and guides ions as an ion beam from the ions output from the first vacuum chamber, a third vacuum chamber which has a first ion optical separation device or means, a fourth vacuum chamber which has a cell into which reaction gas is introduced, and a fifth vacuum chamber which has a second optical separation device or means and a detector, wherein the second vacuum chamber and third vacuum chamber are individually evacuated.07-11-2013
20130175443Quadrupole Mass Spectrometer With Enhanced Sensitivity And Mass Resolving Power - A novel method and mass spectrometer apparatus is introduced to spatially and temporally resolve images of one or more ion exit patterns of a multipole instrument. In particular, the methods and structures of the present invention measures the ion current as a function of time and spatial displacement in the beam cross-section of a quadrupole mass filter via an arrayed detector. The linearity of the detected quadrupole ion current in combination with it reproducible spatial-temporal structure enables the deconvolution of the contributions of signals from individual ion species in complex mixtures where both sensitivity and mass resolving power are essential.07-11-2013
20130168548ION-BASED BREATH ANALYSIS SYSTEM - Disclosed embodiments include systems for analyzing the breath of a patient for the presence of one or more analytes of interest. The systems may include an ion detection system capable of receiving a gas mixture having an analyte of interest expired by a patient, flowing the gas mixture, and ionizing molecules within the gas mixture. The molecules include at least the analyte of interest. The ion detection system is also capable of detecting the ionized analyte of interest.07-04-2013
20120248305MASS SPECTROMETER - In the spectrometer, heavy loads are arranged centrally inside a case having a height smaller than a width, and having a depth smaller than the height. The heavy loads include a vacuum chamber, a vacuum pump which evacuates the vacuum chamber, a sample introduction unit which introduces a sample to be measured and evaporates the sample, an ionization unit which ionizes the evaporated sample and provides it to the vacuum chamber, and an ion detection unit which is connected to the vacuum chamber. Circuit board storage units which store a plurality of circuit boards with a predetermined space therebetween are formed on both sides along a width direction of the case.10-04-2012
20130140455MULTI-DOPANT PERMEATION TUBE - Aspects and embodiments of the present invention are directed to spectrometry systems and for apparatus and methods for delivering dopants to same. In one example, there is provided a dopant delivery device configured to supply dopants to a spectrometry system comprising a tube including a first chamber and a second chamber, a first dopant source included in the first chamber, and a second dopant source included in the second chamber.06-06-2013
20090001265Ion trap, mass spectrometer and ion mobility analyzer using the ion trap - A mass spectrometer using a one-dimensional ion trap is disclosed. The mass spectrometer having the one-dimensional ion trap can trap a great amount of ions, and the provision of a mass spectrometric analyzer capable of operation in a low vacuum eliminates the need of a high vacuum.01-01-2009
20100276590Microengineered Vacuum Interface for an Ionization System - A planar component for interfacing an atmospheric pressure ionizer to a vacuum system is described. The component combines electrostatic optics and skimmers with an internal chamber that can be filled with a gas at a prescribed pressure and is fabricated by lithography, etching and bonding of silicon.11-04-2010
20100276589Atmospheric pressure ion source moving transport interface for a mass spectrometer - An atmospheric pressure (AP) mass spectrometry ion source able to ionize analytes in liquid effluents from interfaced liquid separation techniques and from individual containers, as in microtiter plates, by direct introduction of the analyte into the ion source using a moving ribbon, wire, or belt with vaporization of the analyte and subsequent ionization using an electric discharge or photoionization. The AP source may also incorporate atmospheric pressure chemical ionization (APCI), photoionization (APPI) and/or electrospray ionization (ESI), techniques that are commercially available. The source facilitates ionization of volatile and semivolatile compounds by applying heat from a gas stream to vaporize analyte entering the ionization region on a moving transport device. Solvent removal prior to sample entering the ionization region enables ionization of a wider range of compounds than liquid introduction APCI or APPI. The source is also capable of ionizing non-volatile compounds in solution by electrospray ionization, thus the combination provides almost universal ionization for organic compounds.11-04-2010
20110210245Device for Generating Wide Spectral Band Laser Pulses, Particularly for a Tomographic Atom Probe - A wide spectral band laser pulse generating device capable of covering a spectrum formed of given wavelengths is provided, including: a monochromatic laser light source whose intensity is adjustable; non-linear optical means, a photonic crystal or a microstructured optical fiber for example, for carrying out spectral widening of the wave emitted by the light source; the light source and the non-linear optical means are configured and arranged so as to create a white supercontinuum whose continuous spectrum contains the wavelengths considered. The invention relates to the general field of the analysis of the composition of material specimens, and in particular to laser tomographic atom probes.09-01-2011
20110220790DEVICE FOR SEPARATING, ENRICHING AND DETECTING IONS - A device for separating, enriching and detecting ions comprises: a gas tube, in which a carrier gas flows at a uniform rate; an ion source; multiple electrodes provided in the gas tube and applied with electric voltages respectively, so that at least an electric field is produced along the axis of the gas tube; an ion detector; and an ion extraction channel, by which specific enriched ions will be guided across the side wall of the gas tube toward the ion detector and be analyzed. The device enriches ions utilizing the following characteristic: compound ions with specific ion mobility maintain a dynamic balance for a period of time in a flow field under the combination of a carrier gas and a suitable electrical field against the direction of the carrier gas. Simultaneously, multiple compound particles with different ion motilities can be separated and enriched at positions with different electrical field intensities in a flow field in the same manner. The device also comprises synchronously export latitudinally enriched ions at different positions in a flow field, and performs later mass analysis using a mass spectrometer.09-15-2011
20130146762Mass Spectrometer - An ion-ion reaction cell is provided comprising a plurality of electrodes forming an ion guide. A transient DC voltage wave is applied to the electrodes in order to load reagent anions into the ion guide. Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.06-13-2013
20130146760SYSTEM AND METHOD FOR ION IMPLANTATION WITH IMPROVED PRODUCTIVITY AND UNIFORMITY - A scanning system including a scanning element, a beam profiler, analysis system, and a ZFE-limiting element, is disclosed. The scanning element is configured to scan an ion beam over an ion beam scan path. The beam profiler measures beam current of the ion beam as it is scanned over the ion beam scan path, and the analysis system analyzes the measured beam current to detect a ZFE condition. The ZFE-limiting element, which is upstream of the beam profiler and is coupled to the analysis system via a feedback path, is configured to selectively apply an electric field to the scanned ion beam based on whether the ZFE condition is detected. The selectively applied electric field induces a change in the scanned beam to limit the ZFE condition.06-13-2013
20130146761INTRODUCTION OF IONS INTO KINGDON ION TRAPS - The geometry of a Kingdon ion trap, in which harmonic ion oscillation in a potential well in a longitudinal direction is completely decoupled from ion oscillation in a direction transverse to the longitudinal direction, is arranged so that the oscillating ions introduced through the entrance tube cannot return to the entrance tube until they have performed several longitudinal oscillations during which time heavier ions can be introduced into the trap. In one embodiment, ions enter the trap via an entrance tube extending through, but electrically insulated from, one of the Kingdon trap housing electrodes and located outside the minimum of the potential well in the longitudinal direction.06-13-2013
20100301207Mass Spectrometer - A detachable and replaceable ion source for a mass spectrometer. The ion source comprises a housing which defines an ion source chamber, an ion source mounting means complementary to mounting means on the mass spectrometer to detachably couple with the mass spectrometer. This allows movement of the housing to bring the ion source chamber into a position of use at the inlet of said mass spectrometer and to take the ion source chamber from said position of use into a retracted position. Sealing means is provided to create an air tight seal between the housing and the mass spectrometer when the ion source chamber is in its position of use. A release mechanism is provided which cooperates with the mass spectrometer to allow the said movement of said housing.12-02-2010
20120273675SAMPLING SYSTEM FOR USE WITH SURFACE IONIZATION SPECTROSCOPY - In various embodiments of the invention, a device permits more efficient collection and transmission of ions produced by the action of a carrier gas containing metastable neutral excited-state species into a mass spectrometer. In one embodiment of the invention, the device incorporates the source for ionization in combination with a jet separator to efficiently remove excess carrier gas while permitting ions to be more efficiently transferred into the vacuum chamber of the mass spectrometer. In an embodiment of the invention, improved collection of ions produced by the carrier gas containing metastable neutral excited-state species at greater distances from between the position of the analyte and the position of the mass spectrometer are enabled.11-01-2012
20120273674Resolution Enhancement For Ion Mobility Spectrometers - In an ion mobility spectrometer in which a gas pushes ions along a spectrometer axis against and over an electrical field barrier, the electric field barrier is generated with a plateau of slightly increasing height along the axis of the spectrometer. Alternately, the electric filed barrier may have a plateau with constant height, but the gas flow decreases in velocity along the axis of the spectrometer in the vicinity of the plateau.11-01-2012
20110272575LOCALIZED DROPLET HEATING WITH SURFACE ELECTRODES IN MICROFLUIDIC CHIPS - A microfluidic device for droplet manipulation includes a substrate, a plurality of electrically addressable thin-film electrodes disposed on the substrate, at least one of the plurality of electrodes comprising a heating element in the form of a patterned electrode. A hydrophilic region is disposed in or above a portion of the heating element. The hydrophilic region may be permanent or electronically actuable. The thin-film electrodes have multi-function capabilities including, for instance, heating, temperature sensing, and/or sample actuation.11-10-2011
20130153763NANOPOROUS VACUUM PUMP - The invention provides an element (06-20-2013
20130181127TANDEM QUADRUPOLE MASS SPECTROMETER - All data obtained from an A/D converter during a summation period with values exceeding a prescribed threshold is excluded from summation up to a prescribed maximum number of deletions, and the values of the remaining data are summed to find one piece of measurement data corresponding to that summation period. The number of pieces of noise data reflecting the influx of particles that cause spike-like noise is extremely small, so noise data is removed in a state in which there are no signals and no target ions are present. When target ions are present, legitimate data which is not noise data may be removed, but the number of pieces of removed data is small in comparison to the total number of pieces of data, so the effects of the removal of legitimate data essentially do not emerge in the summation results. It is therefore possible to effectively reduce spike-like noise.07-18-2013
20110291003Mass Spectrometer - A spectrometer is offered which can reduce ion loss compared with the prior art even when ions selected by the mass analyzer are modified. The spectrometer includes an ion source for ionizing a sample, an ion storage portion for repeatedly performing a storing operation for storing ions created by the ion source and an expelling operation for expelling the stored ions as pulsed ions, the mass analyzer for passing pulsed ions expelled from the ion storage portion and selecting desired ions according to their mass-to-charge ratio, a detector for detecting pulsed ions passed through the mass analyzer and outputting an analog signal responsive to the intensity of the detection, and a controller for maintaining constant the mass-to-charge ratio of the desired ions selected by the mass analyzer while pulsed ions including the desired ions are passing through the mass analyzer.12-01-2011
20110303842Chromatograph Mass Spectrometer - When performing an automatic MS12-15-2011
20110315875IONIZATION CELL FOR A MASS SPECTROMETER, AND CORRESPONDING LEAK DETECTOR - An ionization cell for a mass spectrometer (12-29-2011
20110315874Mass Spectrometer - When specimen (12-29-2011
20110315873Ion Storage Device with Direction-Selective Radial Ejection - The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.12-29-2011
20130206982ION MOBILITY TUBE - An ion mobility tube comprises an ionization source chamber having a center ionization source chamber hole, an ion door, a mobility region unit having a center mobility tube chamber, a constraining grid, and a Faraday disk, and the ionization source chamber, the ion door, the mobility region unit, the constraining grid, and the Faraday disk are laminated together in sequence in a front-rear direction, wherein the mobility region unit comprises a first insulator and first metal electrode sheets concentrically fixed to a front surface and a back surface of the first insulator respectively. The mobility region unit comprises the first insulator and the first metal electrode sheets which are integral. Therefore, the ion mobility tube is advantageous in simplified manufacturing, and convenient for detachment and assembly.08-15-2013

Patent applications in class With sample supply means