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With collection of ions

Subclass of:

250 - Radiant energy

250281000 - IONIC SEPARATION OR ANALYSIS

250282000 - Methods

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Class / Patent application numberDescriptionNumber of patent applications / Date published
250284000 For material recovery 1
20100243885METHODS AND APPARATUS FOR EXTRACTING AIR CONTAMINANTS - In accordance with the present invention there are provided methods and devices for ozone-free electrostatic extraction of contaminating particles. The devices include spatially separated areas of particle ionization by electrospraying and of electrostatic particles precipitation. Electrospray sources include arrays of porous polymer wicks and porous polymeric ribbons.09-30-2010
Entries
DocumentTitleDate
20090194686METHODS FOR FRAGMENTING IONS IN A LINEAR ION TRAP - Methods for fragmenting ions retained in an ion trap are described. In various embodiments, a non-steady-state pressure of a neutral collision gas of less than about 5×1008-06-2009
20100019143Ion Focusing and Detection in a Miniature Linear Ion Trap for Mass Spectrometry - A miniature linear ion trap (MLIT) with a length of less than 30 mm is provided for ion focusing in the axial plane. The MLIT has multipoles for applying an AC voltage to ions and tubular entrance and exit lenses for applying a DC voltage to the ions. In another aspect, MLIT includes electrodes within the tubular entrance and exit lenses for detection of image current. A method is also provided for applying voltage to the entrance and exit lenses for ion focusing.01-28-2010
20080210860Segmented ion trap mass spectrometry - An ion trap is provided with at least two discrete trapping regions or segments. Both segments are located in a vacuum chamber of a mass spectrometer system. An entrance of the ion trap is disposed downstream to a laser based ionization source to receive the ions with a wide range of kinetic energies that have been generated by the laser-based ionization source. Once sufficient ions have been accumulated in the first segment and sufficient time has passed to cool the ions, they are transferred to the second segment and ultimately ejected through an aperture or slot to a detector arrangement to produce a mass spectrum.09-04-2008
20130075602MASS SPECTROMETRIC ION STORAGE DEVICE FOR DIFFERENT MASS RANGES - The invention relates to devices and methods for the storage of ions in mass spectrometers. The invention proposes the generation and superposition of two multipole fields of different order, independent of each other, in an RF multipole rod system. In an embodiment with eight pole rods, for example, it is thus possible to jointly store low-energy electrons in a central RF quadrupole field, which effectively acts only on electrons and holds them together radially, on the one hand, and multiply charged heavy positive ions in an RF octopole field, which effectively acts only on the ions, on the other hand, in order to fragment the positive ions by electron capture dissociation (ECD). In a different embodiment, multiply charged positive analyte ions and suitable negative reactant ions can react with each other in an octopole field by electron transfer dissociation (ETD) with a high fragmentation yield, and the fragment ions can subsequently be bundled by a transition to a quadrupole field to form a fine ion beam, which can leave the multipole rod system axially. A mixture of hexapole and dodecapole systems is also possible.03-28-2013
20080258053ALL-MASS MS/MS METHOD AND APPARATUS - A method of obtaining a mass spectrum of elements in a sample is disclosed. Sample precursor ions having a mass to charge ratio M/Z are generated, and fragmented at a dissociation site, so as to produce fragment ions of mass to charge ratio m/z. The fragment ions are guided into an ion trap of the electrostatic or “Orbitrap” type, the fragment ions entering the trap in groups dependent upon the precursor ions M/Z. The mass to charge ratio of each group is determined from the axial movement of ions in the trap. The electric field in the trap is distorted. Ions of the same m/z, that are derived from different pre-cursor ions, are then separated, because the electric field distortion causes the axial movement to become dependent upon factors other than m/z alone.10-23-2008
20100163724APPLICATIONS OF HYDROGEN GAS GETTERS IN MASS SPECTROMETRY - The present invention is an electrically controlled gettered pump assembly to entrain and fully release hydrogen gas to regulate the pressure and buffer the ions in an ion trap mass spectrometer and other portable analytical instruments. In addition to the gettered pump assembly, the present invention also incorporates a microvalve between the different chambers to release and control the hydrogen content. Hydrogen gas regulates the pressure in mass spectrometers and also acts as a buffering gas to prevent the ions from escaping the trap.07-01-2010
20100032561Mass Spectrometer - A mass spectrometer is disclosed comprising a device (02-11-2010
20090212209Optimization of Excitation Voltage Amplitude for Collision Induced Dissociation of Ions in an Ion Trap - Collision induced dissociation of precursor ions in an ion trap is performed by determining a predicted fragmentation-optimized excitation voltage amplitude based on an indicator of damping gas pressure, such as a damping gas flow rate, and optionally other parameters including precursor ion m/z and an indicator of the Mathieu parameter q. The excitation voltage may then be applied to electrodes of the ion trap in steps of increasing amplitude, wherein at least one of the amplitudes corresponds to the predicted optimum value. Application of the excitation voltage in this manner produces favorable fragmentation efficiencies over a range of operating parameters and for ions of differing chemical properties.08-27-2009
20100108880LINEAR ION TRAP AS ION REACTOR - In a linear ion trap ions of both positive and negative polarities are stored simultaneously for fragmentation reactions caused by electron transfer dissociation (ETD). The ion trap comprises a plurality of parallel pole rods or stacked rings and the ions are stored by applying two phases of a first RF voltage to the pole rods or stacked rings in alternation, thereby radially confining both positive and negative ions. A second, single-phase RF voltage is applied to all the pole rods or stacked rings in common and creates a pseudopotential barrier at the ends of the linear ion trap that acts axially on ions of both polarities in order to maintain the ions in the trap.05-06-2010
20100108879Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer (05-06-2010
20100108878Mass Spectrometer - A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter (05-06-2010
20130026359METHOD AND APPARATUS FOR GENERATING AND ANALYZING IONS - The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.01-31-2013
20120181422Mass Spectrometer and Methods of Mass Spectrometry - A mass spectrometer is disclosed, comprising: a chamber; an injection device adapted to inject charged particles into the chamber; and field generating apparatus. The field generating apparatus is adapted to establish at least one field acting on the charged particles, the at least one field having an angular trapping component configured to form at least one channel between a rotation axis and the periphery of the chamber, the at least one channel being defined by energy minima of the angular trapping component, the field generating apparatus being further adapted to rotate the angular trapping component about the rotation axis, whereby in use charged particles are angularly constrained along the at least one channel by the angular trapping component to rotate therewith, a centrifugal force thereby acting on the charged particles. The at least one field additionally has a radial balancing component having a magnitude increasing monotonically with increasing radius from the rotation axis, at least in the vicinity of the at least one channel, whereby in use charged particles move along the at least one channel under the combined influence of the centrifugal force and the radial balancing component to form one or more particle orbits according to the charge to mass ratios of the particles. The mass spectrometer further includes a detector configured to detect at least one of the particle orbits. Methods of mass spectrometry are also disclosed.07-19-2012
20090302216MULTIPOLE ION GUIDE FOR PROVIDING AN AXIAL ELECTRIC FIELD WHOSE STRENGTH INCREASES WITH RADIAL POSITION, AND A METHOD OF OPERATING A MULTIPOLE ION GUIDE HAVING SUCH AN AXIAL ELECTRIC FIELD - A mass spectrometer having an elongated rod set, the rod set having a first end, a second end, a plurality of rods and a central longitudinal axis is described as is a method operating same. Embodiments involve a) admitting ions into the rod set; b) producing an RF field between the plurality of rods to radially confine the ions in the rod set, wherein the RF field varies along at least a portion of a length of the rod set to provide, for each of the ions, a corresponding first axial force acting on the ion to push the ion in a first axial direction; and, c) for each of the ions, providing a corresponding second axial force to push the ion in a second axial direction opposite to the first axial direction; wherein the corresponding first axial force increases relative to the corresponding second axial force with radial displacement of the ion from the central longitudinal axis in any direction orthogonal to the central longitudinal axis such that the first corresponding axial force is less than the corresponding second axial force when the ion is less than a threshold radial distance from the central longitudinal axis and the corresponding first axial force exceeds the corresponding second axial force when the ion is radially displaced from the central longitudinal axis by more than the threshold radial distance in any direction orthogonal to the central longitudinal axis.12-10-2009
20090302215METHOD OF OPERATING TANDEM ION TRAPS - A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.12-10-2009
20130214152TOROIDAL ION TRAP MASS ANALYZER WITH CYLINDRICAL ELECTRODES - A combination of electrodes that are cylindrical and an asymmetric arrangement of cylindrical and planar electrodes are used to create electric fields that compensate for toroidal curvature in a toroidal ion trap, the design lending itself to high precision manufacturing and miniaturization, converging ion paths that enhance detection, higher pressure operation, and optimization of the shape of the electric fields by careful arrangement of the electrodes.08-22-2013
20090134325METHODS FOR DETECTING ESTRADIOL BY MASS SPECTROMETRY - Provided are methods for determining the amount of estradiol in a sample using mass spectrometry. The methods generally involve ionizing estradiol in a sample and detecting and quantifying the amount of the ion to determine the amount of estradiol in the sample.05-28-2009
20110284739DETECTION APPARATUS - An ion mobility spectrometer has a pair of electrodes and midway along the drift chamber. A high field is applied between the electrodes and sufficient to modify ions in the region of thee electrodes such that they move at a different rate towards the collector plate. This is used to modify the time of flight of selected ions or ion clusters and enable identification of ambiguous peaks on the IMS spectrum.11-24-2011
20110284738CONFINING POSITIVE AND NEGATIVE IONS IN A LINEAR RF ION TRAP - In a linear ion trap, ions with two polarities are confined radially via an RF potential between the rods comprising the trap. Axially, ions of at least one polarity are confined via DC potentials applied to the elements of the trap or electrodes at the ends of the trap whereas ions of the other polarity are axially confined by a combination of pseudopotentials and/or DC potentials.11-24-2011
20100090102ION MOBILITY MEASUREMENT AT A POTENTIAL BARRIER - Ion mobilities are measured by entraining the ions in a gas and adiabatically expanding the ion-containing gas through a nozzle to form a gas jet. An electrical field barrier with variable height is located at the nozzle exit. The field barrier may be located adjacent to the nozzle exit or an ion guide may be located between the nozzle and the field barrier. If a continuous ion current is supplied, the height of the barrier is varied and the ion current of the ions passing over the barrier is measured, the ion current can be differentiated to generate a mobility spectrum. Alternatively, the ions can be temporarily stored in the ion guide so that measurement of the ion current of the ions passing over the barrier results in a direct measurement of the mobility spectrum.04-15-2010
20110291001Ion Mobility Spectrometer - An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (12-01-2011
20100019144AUTOMATIC GAIN CONTROL (AGC) METHOD FOR AN ION TRAP AND A TEMPORALLY NON-UNIFORM ION BEAM - An automatic gain control (AGC) technique and apparatus is introduced herein for any temporally non-uniform ion beam, such as, for example, an ion beam produced by a MALDI ion source so as to minimize space charge effects. The disclosed configurations and techniques can be achieved by using an ion optical gating element and applying a desired signal waveform (e.g., a square wave) having a predetermined duty cycle. The applied voltage amplitude of such a signal can be configured to switch between a voltage which fully transmits the ions, and a voltage which does not transmit any ions. The frequency is chosen to result in a period which is significantly lower than the smallest non-uniformity period. Techniques of the present invention can also be extended to methods of AGC which can use a single ion injection event from the ion source to avoid variations in ion numbers from an unstable ion source.01-28-2010
20100078552SUBSTRATE FOR MASS SPECTROMETRY AND MASS SPECTROMETRY METHOD - A substrate for mass spectrometry includes a first reflective member that is semi-transmissive/semi-reflective, a transparent member, and a second reflective member that is reflective, sequentially provided to form an optical resonator. The optical resonator includes, on a surface of the first reflective member, a sample separation portion at which surface interaction occurs with a plurality of analytes contained in a sample liquid. The analytes are separated on the sample separation portion to perform mass spectrometry on each of the analytes. A sample in contact with the surface of the first reflective member is irradiated with laser beam L to generate resonance in the optical resonator, and an electric field on the surface of the first reflective member is enhanced by the resonance. The enhanced electric field is utilized to ionize analytes S in the sample and to desorb the analytes S from the surface.04-01-2010
20100084548Parallel ion parking in ion traps - A method of controlling ion parking in an ion trap includes generating a trapping field for trapping cations and anions, and applying a tailored waveform during a period when ion/ion reactions occur to park first generation product ions with m/z values that differ from those of a cation and an anion in selected m/z regions. In particular, the tailored waveform inhibits simultaneously the reactions of ions of disparate m/z ratios.04-08-2010
20090294654DETECTION OF POSITIVE AND NEGATIVE IONS - An ion detector comprises an ion guide with electrodes arranged about a first axis; a positive ion detection device with an ion inlet at a first side of the ion output section offset from and at an angle to the first axis; and a negative ion detection device with an ion inlet at a second side opposite the first side, offset from and at an angle to the first axis. A negative voltage bias applied to the positive ion device accelerates positive ions toward the inlet along a path including a component along a second axis orthogonal to the first axis. A positive voltage bias applied to the negative ion detection device accelerates negative ions toward the inlet along a path that includes a component along the second axis orthogonal to the first axis in a direction generally opposite to the path of the positive ions.12-03-2009
20100084549Electrostatic Ion Trap - An electrostatic ion trap confines ions of different mass to charge ratios and kinetic energies within an anharmonic potential well. The ion trap is also provided with a small amplitude AC drive that excites confined ions. The mass dependent amplitudes of oscillation of the confined ions are increased as their energies increase, due to an autoresonance between the AC drive frequency and the natural oscillation frequencies of the ions, until the oscillation amplitudes of the ions exceed the physical dimensions of the trap, or the ions fragment or undergo any other physical or chemical transformation.04-08-2010
20090206248ION ENERGY SPREAD REDUCTION FOR MASS SPECTROMETER - A method for reducing the energy spread of ions over a specific and limited mass to charge ratio range is disclosed, along with an ion deceleration arrangement for implementing such a method. An electric field, having an electric field strength E is generated by a deceleration electrode arrangement (08-20-2009
20090090860ION TRAP MASS SPECTROMETRY - Disclosed is an ion trap mass spectrometer for MS04-09-2009
20090272895MASS SPECTROMETER WITH ION STORAGE DEVICE - A method of mass spectrometry having steps of, in a first cycle: storing sample ions in a first ion storage device, the first ion storage device having an exit aperture and a spatially separate ion transport aperture; ejecting the stored ions out of the exit aperture; transporting the ejected ions into an ion selection device which is spatially separated from the said first ion storage device; carrying out ion selection within the spatially separated ion selection device; returning at least some of the ions ejected from the first ion storage device, or their derivatives, back from the spatially separate ion selection device to the first ion storage device, following the step of ion selection; receiving the said returned ions through the ion transport aperture of the first ion storage device; and storing the received ions in the first ion storage device.11-05-2009
20090294657DRIVING A MASS SPECTROMETER ION TRAP OR MASS FILTER - A radio frequency (RF) drive system and method for driving the ion trap or mass filter of a mass spectrometer has a programmable RF frequency source coupled to a RF gain stage. The RF gain stage is transformer coupled to a tank circuit formed with the ion trap or mass filter. The power of the RF gain stage driving the ion trap or mass filter is measured using a sensing circuit and a power circuit. A feedback value is generated by the power circuit that is used to adjust the RF frequency source. The frequency of the RF frequency source is adjusted until the power of the RF gain stage is at a minimum level. The frequency value setting the minimum power is used to operate the RF drive system at the resonance frequency of the tank circuit formed with the transformer secondary inductance and the ion trap or mass filter capacitance. Driving a mass spectrometer mass selection element this way results in the lower power consumption, an inherently filtered clean drive signal, smaller size, and reduced electromagnetic emissions.12-03-2009
20090294655ION TRAP ARRAY - The invention “Ion Trap Array (ITA)” pertains generally to the field of ion storage and analysis technologies, and particularly to the ion storing apparatus and mass spectrometry instruments which separate ions by its character such as mass-to-charge ratio. The aim of this invention is providing an apparatus for ion storage and analysis comprising at least two or more rows of parallel placed electrode array wherein each electrode array includes at least two or more parallel bar-shaped electrodes, by applying different phase of alternating current voltages on different bar electrodes to create alternating electric fields inside the space between two parallel electrodes of different rows of electrode arrays, multiple linear ion trapping fields paralleled constructed in the space between the different rows of electrode arrays which are open to adjacent each other without a real barrier. This invention also provides a method for ion storage and analysis involving with the trapping, cooling and mass-selected analyzing of ions by this apparatus mentioned which constructs multiple conjoint linear ion trapping fields in the space between the different rows of electrode arrays12-03-2009
20090294656FRAGMENTATION OF IONS IN KINGDON ION TRAPS - Fragment ion spectra are acquired in Kingdon ion traps that have a potential well for harmonic oscillations of the ions in the longitudinal direction and in which the ions can oscillate radially in a plane between two or more inner electrodes. Metastable ions, preferably produced by laser desorption, are introduced into the Kingdon ion trap close to the minimum of the longitudinal potential well and stored there locally for a predetermined time period. Excess internal energy in the metastable ions causes most of the ions to decompose ergodically to fragment ions. Then the fragment ions and any remaining analyte ions are excited to execute harmonic oscillations in the longitudinal potential well. The harmonic oscillations are measured as image currents, from which a high-resolution mass spectrum of the fragment ions can be calculated.12-03-2009
20090261242APPARATUS FOR AND METHOD OF WITHDRAWING IONS IN EUV LIGHT PRODUCTION APPARATUS - An ion withdrawal apparatus that withdraws ions emitted from a plasma in an EUV light production apparatus in which a target at an EUV light production point is irradiated with laser light to be made in a plasma state and the target emits EUV light, the ion withdrawal apparatus which includes: a collector mirror that is disposed in a direction opposite to a laser light incidence direction to collect the EUV light and has a hole for the ions to pass therethrough; magnetic line of force production means that produces a magnetic line of force that is parallel or approximately parallel to the laser light incidence direction at or in the vicinity of the EUV light production point; and ion withdrawal means that is disposed on the opposite side of the collector mirror from the EUV light production point and withdraws the ions.10-22-2009
20100102219ION GATE FOR DUAL ION MOBILITY SPECTROMETER AND METHOD THEREOF - Disclosed is an ion gate for a dual IMS and method. The ion gate includes an ion source, a first gate electrode placed on one side of the ion source, a second gate electrode placed on the other side of the ion source, a third gate electrode placed on the side of the first gate electrode away from the ion source, a fourth gate electrode placed on the side of the second gate electrode away from the ion source, wherein during the ion storage, the potential at the position on the tube axis of the ion gate corresponding to the first gate electrode is different from the potentials at the positions on the tube axis corresponding to the ion source and the third gate electrode, and the potential at the position on the tube axis corresponding to the second gate electrode is different from the potentials at the positions on the tube axis corresponding to the ion source and the fourth gate electrode. According to the present invention, after sample gas enters the ion gates, charge exchange with reaction ions occurs between the first gate electrode and the second electrode, and positive and negative ions are continuously stored into the storage regions for the positive and negative ions. This leads to an improvement of utility rate of ions. Then, the ions are educed in a step-wise manner from the storage regions for the positive and negative ions by a simple control of a combination of the electrodes.04-29-2010
20080302959PULSED FLOW MODULATION GAS CHROMATOGRAPHY MASS SPECTROMETRY WITH SUPERSONIC MOLECULAR BEAMS METHOD AND APPARATUS - There is provided a pulsed flow modulation gas chromatograph mass spectrometer with supersonic molecular beams apparatus and method for improved sample analysis. The apparatus includes a gas chromatograph with an injector for the analysis of sample compounds, a first analytical column in the gas chromatograph, a sample storage, a gas pulse generator, a pressure generator, a conduit for transferring the sample compounds into a second analytical column having a different polarity than the polarity of the first analytical column, a second gas pulse generator, a transfer line for transferring the sample compounds into a supersonic nozzle, a member for adding a makeup gas to the output gas flow of the second analytical column before the supersonic nozzle, an element for reducing the flow rate of the added makeup gas, a supersonic nozzle for the expansion of the sample with the combined second analytical column and added makeup gas, a fly-through electron ionization ion source, a mass analyzer, an ion detector for the detection of the ions of the sample compounds after their mass analysis, a data processor and presenter, and a repeater for repeating the cycle of the first gas pulse of relatively high flow rate followed by the second gas pulse of intermediate flow rate.12-11-2008
20090314935Mass Spectrometer - A mass analyser (12-24-2009
20080272288Method and apparatus for scaling intensity data in a mass spectrometer - A method includes: accumulating ions having a plurality of m/z values in an ion trap during a time interval; deriving from the accumulated ions a respective intensity value for each of the m/z values; and adjusting each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value. According to a different aspect, an apparatus includes a first portion with an ion trap, and a second portion. The second portion causes the ion trap to accumulate ions with a plurality of m/z values during a time interval, derives from the accumulated ions in the ion trap a respective intensity value for each of the m/z values, and adjusts each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value.11-06-2008
20090050799Transition molding - An apparatus and method for measuring low or trace concentrations of compounds and mixture of gases. A method and apparatus of the invention permits separating ions of different mobilities by passing them through an abrupt change or step in electric field magnitude. By using the separation method, the compounds of interest may be measured with less interference from other compounds of the gas mixture, which reduces or eliminates the need for prior separation of the components of the gas mixture. Several embodiments of the invention are described including the use of current amplifiers on one, or more, parts of the apparatus. While a single screen can provide a chamber which is divided into two regions of different electric fields, it is within the scope of the invention to include multiple screens to provide several steps in the electric field permitting it to be possible to trap and measure ions with successively higher mobilities. The gases used include halogenated compounds, including fluorocarbons, and most preferable SF02-26-2009
20090179150MASS SPECTROMETER WITH LOOPED ION PATH - A mass spectrometer includes at least one ion selector, at least one collision cell, and an ion path switching device arranged to define a looped ion path around which ions derived from a sample may be sent multiple times (without reversal of ion travel) in order to effect a desired number of isolation/fragmentation cycles for MSn analysis. When the desired number of isolation/fragmentation cycles have been completed, the ion path switching device directs the ions to a detector or a separate mass analyzer for acquisition of a mass spectrum.07-16-2009
20090242753DEVICE AND MASS ANALYSIS OF MOLECULES USING UV OR VISIBLE LASER BEAM PHOTODISSOCIATION - The invention relates to a device for mass analysis of molecules comprising a quadripolar ion trap equipped with an inlet for injection of molecules to be analysed in ionised form and an outlet for ejection of the ions to be detected, comprising an electrode system for generating a three-dimensional quadripolar field, capable of trapping the molecules to be analysed in ionised form, as a function of their mass to charge (m/z) ratio in a trapping volume, said trap being coupled to a UV or visible laser beam ensuring dissociation of the molecules to be analysed, characterised in that the laser beam is introduced to the trap without passing via fibre optics via an opening made in one of the electrodes, separate from the inlet and the outlet and blocked tightly by a viewing window allowing the laser beam to pass through, the dimension of the viewing window being selected such that the laser beam covers the entire trapping volume, as well as a process for mass analysis, with laser beam dissociation.10-01-2009
20100276586INTRASCAN DATA DEPENDENCY - A mass spectrometer data dependent method and apparatus is introduced to alter scanning parameters based upon data acquired during that scan. Such a method an apparatus may include the identification of ion species of interest meeting user specified criteria so that a determination can be made as to whether or not the present scan is to be continued, terminated, or alternatively paused while such a decision is being made. Such a method of operation saves overall cycle time and allows examination of, for example, marker ion ratios for additional peptides that might otherwise be missed.11-04-2010
20100230589Method and Apparatus for Surface Desorption Ionization by Charged Particles - An apparatus and method for generating analyte ions from a sample. An ion generating device is provided having a chamber with an outlet and a surface having a material and means for applying a high velocity gas flow through the chamber toward the outlet such that charged particles are produced by physical interaction between the high velocity gas and the material. The charged particles then induce the generation of primary ions by interaction with molecules of the high velocity gas. The primary ions are emitted from the outlet of the ion generating device toward a sample-bearing surface and analyte ions are generated by impact of the primary ions on the analyte sample on the surface.09-16-2010
20100237236Method Of Processing Multiple Precursor Ions In A Tandem Mass Spectrometer - A method of processing multiple precursor ions in a tandem mass spectrometer includes generating a plurality of precursor ions with an ion source. At least some of the plurality of precursor ions is trapped in an ion trap. At least two precursor ions of interest are isolated from the plurality of precursor ions with a filtered noise field. Precursor ions of interest are sequentially ejected toward a collision cell. The sequentially ejected precursor ions of interest are fragmented in a collision cell. The mass-to-charge ratio spectra of the fragmented ions are then determined with a mass spectrometer.09-23-2010
20120138787SENSING TECHNIQUES FOR ON-FARM ANALYSIS OF MILK COMPONENTS - A method of analysing milk components having the steps of collecting a milk sample, ionizing the milk sample, and using an ion mobility spectrometer to detect predetermined components within the ionized milk sample, wherein the ion mobility spectrometer is positioned within a milking system from which the milk sample is taken.06-07-2012
20100252730Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion trap (10-07-2010
20110057098TARGETED ION PARKING FOR QUANTITATION - A plurality of targeted ion characteristics and a charge reduction amount are received. A subset of ionized molecules of a sample corresponding to each characteristic of the plurality of targeted ion characteristics is transmitted from a first location to a second location, producing a plurality of selected ionized molecules. Reagent ions are transmitted to the second location to reduce the charge state of the selected ionized molecules. The charge state reduction of the selected ionized molecules is stopped at the charge state reduction amount, producing a plurality of parked targeted ions in the second location. The targeted ion characteristics can include mobilities or mass-to-charge ratios. Quantitation information for an analyte can be obtained by performing targeted ion parking on a plurality of standards, developing a calibration function, performing targeted ion parking on a sample and using the calibration function to determine the concentration of the analyte in the sample.03-10-2011
20110057097Mass Spectrometer - A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods 03-10-2011
20080230691METHOD FOR OPERATING AN ION TRAP MASS SPECTROMETER SYSTEM - A method of operating a mass spectrometer system having an ion trap is provided. The method comprises encoding a selected characteristic in at least one of the first group of precursor ions and the first plurality of fragments, wherein the encoding operation is applied to at least one of the first group of precursor ions and the first plurality of fragments without being applied to other ions such that the first plurality of fragment ions has the first selected characteristic and the other ions lack the first selected characteristic.09-25-2008
20120032074Mass Spectrometer Arranged To Perform MS/MS/MS - A mass spectrometer is disclosed comprising an ion trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyser for subsequent mass analysis.02-09-2012
20100301204INTRODUCTION OF IONS INTO KINGDON ION TRAPS - In a Kingdon ion trap in which harmonic ion oscillation in a potential well in a longitudinal direction is completely decoupled from ion oscillation in a direction transverse to the longitudinal direction, ions enter the trap via an entrance tube extending through, but electrically insulated from, one of the Kingdon trap housing electrodes and located outside the minimum of the potential well in the longitudinal direction. The geometry of the Kingdon trap is arranged so that the oscillating ions introduced through the entrance tube cannot return to the entrance tube until they have performed several longitudinal oscillations during which time heavy ions can be introduced into the trap.12-02-2010
20110127421Sample Collection and Detection System - A sample collection and detection system is described. The detection system provides a sample chamber fluidly coupled to a secondary ionisation source to allow the introduction of vapour generated from the sample into an ion path generated from the secondary ionisation source. The secondary ionisation source is a secondary electrospray ionisation (SESI) source, and is usefully employed in dust analysis.06-02-2011
20110006200Methods And Apparatus For Mass Spectrometry With High Sample Utilization - A method of measuring a mass spectrum with high sample utilization includes mass filtering a first group of precursor ions from a mass spectrum that has a first predetermined range of mass-to-charge ratios. At least one type of precursor ion in the first group of precursor ions is then selectively fragmented. A first fragment mass spectrum of the fragmented precursor ions in the first group of precursor ions is measured while maintaining other precursor ions in the first predetermined range of mass-to-charge ratios. A second group of precursor ions having a second predetermined range of mass-to-charge ratios is mass filtered from the mass spectrum. At least one type of precursor ion is selectively fragmented in the second group of precursor ions. A second fragment mass spectrum of the fragmented precursor ions in the second group of precursor ions is then measured.01-13-2011
20110024618Mass Spectrometer - An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). A transient DC voltage wave is applied to the electrodes (2) in order to load reagent anions into the ion guide (2). Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.02-03-2011
20110017908DICATIONIC LIQUID SALTS AND METHODS OF USE THEREOF - Dicationic liquid salts and methods of using such dicationic liquid salts in techniques such as ESI-MS are provided.01-27-2011
20110024619Mass Spectrometer Arrangement with Fragmentation Cell and Ion Selection Device - A method of mass spectrometry having the steps of, in a first cycle: storing sample ions in a first ion storage device; ejecting the stored ions out of the first ion storage device into a separate ion selection device; selecting a subset of the ions in the ion selection device; ejecting the subset of ions selected within the ion selection device to a fragmentation device; directing ions from the fragmentation device back to the first ion storage device without passing them through the said ion selection device; receiving at least some of the ions ejected from the first ion storage device, or their derivatives, back into the first ion storage device; and storing the received ions in the first ion storage device.02-03-2011
20110031392Atmospheric pressure ion source probe for a mass spectrometer - An ion source able to ionize both liquid and gaseous vapors from interfaced liquid separation techniques and a solids/liquid atmospheric pressure (AP) probe. The liquid effluents are ionized by electrospray ionization, photoionization or atmospheric pressure chemical ionization and the vapors released from a probe device placed in a heated gas stream in the AP source are ionized by a corona or Townsend electrical discharge or photoionization. The source has the ability to ionize compounds from both liquid and solid sources, which facilitates ionization of volatile and semivolatile compounds by applying heat from a gas stream as well as highly non-volatile compounds infused by electrospray or separated by liquid chromatography or capillary electrophoresis.02-10-2011
20110042562MASS SPECTROMETER WITH AN ELECTROSTATIC ION TRAP - In a mass spectrometer with an electrostatic ion trap, the electrostatic ion trap has an outer electrode with an ion-repelling electric potential applied to it and a plurality of inner electrodes with ion-attracting potentials applied to each inner electrode. The outer electrode and the inner electrodes are shaped and arranged in such a way that a harmonic electric potential is formed in one spatial direction and, perpendicular to this spatial direction, an electric potential is formed in which ions move in stable, radial trajectories.02-24-2011
20110240847TRANSMISSION ENERGY CONTAMINATION DETECTOR - An energy contamination detection apparatus includes a membrane and a charge collection plate disposed at a distance from the membrane. The membrane is configured to receive an ion beam and allow a portion of the ion beam having energy levels above a desired energy level to pass therethrough toward the charge collection plate and absorb or reflect portions of the ion beam having energy levels at or below the desired energy level. A voltage source is electrically coupled to the charge collection plate for providing a bias voltage to the charge collection plate. A detection circuit is coupled to the charge collection plate and is configured to detect energy contamination based on an amount of charge collected on the charge collection plate.10-06-2011
20110240848LOW-PRESSURE ELECTRON IONIZATION AND CHEMICAL IONIZATION FOR MASS SPECTROMETRY - A sample is ionized by chemical ionization by flowing the sample and a reagent gas into an ion source at a pressure below 0.1 Torr. While maintaining the ion source at a pressure below 0.1 Torr, the reagent gas is ionized in the ion source by electron ionization to produce reagent ions. The sample is reacted with the reagent ions at a pressure below 0.1 Torr to produce product ions of the sample. The product ions are transmitted into an ion trap for mass analysis.10-06-2011
20090218485ION-TRAPPING DEVICES PROVIDING SHAPED RADIAL ELECTRIC FIELD - Disclosed are ion cyclotron resonance (ICR) cells and other ion-trapping cells with plural groups of multiple trapping electrodes for shaping (e.g., flattening) the radial electric field within the ICR cell. Also disclosed are methods for controlling the electric field to diminish effects of de-phasing. The diminished effects are achieved by decreasing space-charge contributions by increasing the length of the ion-oscillation path along the z-axis of the ICR cell. The methods and devices enhance the time-domain signal of a Fourier-transform ion-cyclotron resonance mass spectrometer (FTICR-MS) and provide enhanced resolution and accuracy of mass measurements.09-03-2009
20100038530Mass Spectrometer - An ion guide or ion trap (02-18-2010
20100065737MASS SPECTROMETER - A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyser (03-18-2010
20100065738METHOD AND APPARATUS FOR ION AXIAL SPATIAL DISTRIBUTION FOCUSING - The present invention provides a mass spectrometer including an ion source for generating pre-cursor ions, ion fragmentation means for generating fragment ions from the pre-cursor ions, a reflectron for focusing the kinetic energy distribution of the ions, and an ion detector wherein the mass spectrometer also includes axial spatial distribution focusing means which in use acts on the ions after the ion fragmentation means and before the reflectron, the axial spatial distribution focusing means being operable to reduce the spatial distribution of the ions in the direction of the ion optical axis of the spectrometer. Suitably the axial spatial distribution focusing means comprising a cell with two electrodes 03-18-2010
20110248160SYSTEM AND PROCESS FOR PULSED MULTIPLE REACTION MONITORING - A new pulsed multiple reaction monitoring process and system are disclosed that uses a pulsed ion injection mode for use in conjunction with triple-quadrupole instruments. The pulsed injection mode approach reduces background ion noise at the detector, increases amplitude of the ion signal, and includes a unity duty cycle that provides a significant sensitivity increase for reliable quantitation of proteins/peptides present at attomole levels in highly complex biological mixtures.10-13-2011
20080265152Mass Spectrometer - A mass spectrometer is disclosed comprising a High Pressure Liquid Chromatography system (10-30-2008
20100301205LINEAR ION TRAP FOR MSMS - A method and apparatus for acquiring time profiles of ion intensities of product ions in a mass spectrometer is provided. The mass spectrometer comprises an ion trap, a fragmentation module connected to the ion trap, and a mass analyzer module positioned to receive ions from the fragmentation module. Precursor ions, trapped in the ion trap, are ejected from the ion trap in order of m/z ratio. At least of some the precursor ions are fragmented at the fragmentation module to form product ions. Time profiles of ion intensities of the product ions are acquired, the product ions received at the mass analyzer module, by recording a plurality of product mass spectra for each respective precursor ion. The plurality of product mass spectra is processed, using the time profile intensities, to associate respective product ions with the respective precursor ions.12-02-2010
20110174965METHOD FOR COOLING IONS IN A LINEAR ION TRAP - Methods for cooling ions retained in an ion trap are described. In various embodiments, a cooling gas is delivered into a linear ion trap causing a non-steady state pressure elevation in at least a portion of the trap above about 8×1007-21-2011
20100258715Ion Mobility Spectrometer Including Spaced Electrodes for Filtering - An ion mobility spectrometer has an inlet for an analyte substance opening into an ionization region that produces ions of the substance. Parallel grid electrodes extend laterally across the ion flow path and apply an electric field to the ions that is switchable between a relatively low magnitude alternating field that varies in magnitude over multiple periods and an asymmetric alternating field of sufficiently high magnitude to cause differential mobility effects. A collector collects the passed ions, and an indication of the nature of the analyte substance is produced from the collected ions passed during both the low and high field intervals. Also disclosed is the application of a substantially alternating field between the electrodes, which field varies between a low value and a higher value over a time exceeding that of the alternating period.10-14-2010
20080203293Multi-Electrode Ion Trap - This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes.08-28-2008
20100320378METHOD AND APPARATUSES FOR ION CYCLOTRON SPECTROMETRY - An ion cyclotron spectrometer may include a vacuum chamber that extends at least along a z-axis and means for producing a magnetic field within the vacuum chamber so that a magnetic field vector is generally parallel to the z-axis. The ion cyclotron spectrometer may also include means for producing a trapping electric field within the vacuum chamber. The trapping electric field may comprise a field potential that, when taken in cross-section along the z-axis, includes at least one section that is concave down and at least one section that is concave up so that ions traversing the field potential experience a net magnetron effect on a cyclotron frequency of the ions that is substantially equal to zero. Other apparatuses and a method for performing ion cyclotron spectrometry are also disclosed herein.12-23-2010
20100320377LOW VOLTAGE, HIGH MASS RANGE ION TRAP SPECTROMETER AND ANALYZING METHODS USING SUCH A DEVICE - Featured is a quadrupole ion trap mass spectrometer having a compact configuration with a low voltage fundamental RF and using supplemental RF to a very low q12-23-2010
20110133075MASS SPECTROMETER - The mass spectrometer is characterized in that a linear ion trap, that consists of electrodes for mass-selective discharge, is provided with a mechanism that excites ions in a first direction that is perpendicular to the rod axes and a mechanism that simultaneously generates an electric field on the axes in a second direction that is perpendicular to the axial direction and the first direction in order to generate an electric field on the central axis. Highly efficient, high-speed scanning can be achieved using this configuration.06-09-2011
20110168882Mass Spectrometer - A mass spectrometer is disclosed comprising an ion guide (07-14-2011
20100059673Multiple Ion Isolation in Multi-Reflection Systems - This invention relates to a method of operating a charged particle trap in which ions undergo multiple reflections back and forth and/or follow a closed orbit around, usually, a set of electrodes. The invention allows high-performance isolation of multiple ion species for subsequent detection or fragmentation by deflecting ions out of the ion trap according to a timing scheme calculated with reference to the ions' periods of oscillation within the ion trap.03-11-2010
20100001182Tandem differential mobility ion mobility spectrometer for chemical vapor detection - A DMS-IMS chemical sensing system employs two ion-separation technologies in tandem to extract signals of specific chemicals from the glut of signals present. The sensing system generally includes an atmospheric pressure ion generation system, a Differential Mobility (DMS) system, a time-of-flight IMS (TOF-IMS) system, and an ion detector system. The DMS extracts a narrow range of trace chemicals from an environmental sample for subsequent analysis, and a TOF-IMS then analyzes the resulting narrow range of isolated chemicals, allowing compound-specific detection thresholds at sub-ppb concentrations.01-07-2010
20100155595MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.06-24-2010
20120305762ION ISOLATION METHOD AND MASS SPECTROMETER - Disclosed is a method whereby predetermined ions are isolated and ions to be left in an ion trap are left at the time of performing mass spectrometry using the ion trap. In order to have high ion isolation accuracy and to shorten a time necessary for ion isolation, a first time wherein ions having a lower mass than the ions to be left are isolated is set shorter than a second time wherein ions having a higher mass than the ions to be left are isolated.12-06-2012
20080296487Method and system for chemical and physical characterization of complex samples - A method and system for rapid determination of a hydrocarbon type composition, such as crude oils and fractions thereof, and s obtaining the information necessary to assess the yield of commercially valuable fuel and lube oil fractions in a single process, variations of the method and system use Gas Chromatography-FID/Mass Spectrometry and other features, including an auto sampler, a wall coated capillary column, a temperature programmable injector, and a data processing system for compiling and processing the experimental data. The system and method further include a computer system with application software or other processing mechanism and optionally a communication network. One variation provides a graphical user interface for the entry of data and for displaying information, such as in a graphical manner, to show the relationship of various determined outputs and results.12-04-2008
20110315872OXYGEN DETECTION METHOD, AIR LEAKAGE DETERMINATION METHOD, GAS COMPONENT DETECTION DEVICE, AND VACUUM PROCESSING APPARATUS - An oxygen detection method, includes: preparing a grid, an ion collector, and a filament in which an oxide are formed on a surface of metal; controlling a filament current flowing to the filament so that an emission current becomes constant; discharging thermionic electrons which are caused by heat generation by applying the filament current, and generating ions by ionizing a gas; capturing the ions with the ion collector; and detecting oxygen being present in a vacuum processing chamber by measuring a filament current value.12-29-2011
20120001066System and method for grouping precursor and fragment ions using selected ion chromatograms - LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After initial groupings are determined based on retention time, ion peak shapes are compared to determine whether ions should be excluded. Ions having peak shapes not matching other ions, or alternatively a reference peak shape, are excluded from the group.01-05-2012
20110049358Linear Ion Trap - A linear ion trap (03-03-2011
20110049357ION GUIDING DEVICE - An ion guiding device is disclosed comprising a first ion guide (03-03-2011
20110049356Use Ion Guides With Electrodes of Small Dimensions to Concentrate Small Charged Species in a Gas at Relatively High Pressure - The present invention is based on the observation that radio frequency (RF) electric fields in multi-pole lenses with small rod diameters in the range of 1 mm enables strongly concentrating ions suspended in a gas at pressures much higher than previously used for ion manipulation, including atmospheric pressure. Other lens configurations are described, including one based on the funnels of U.S. Pat. No. 6,107,628, and another on the coiled wire system of Hutchins et al. (1999). The finding provides a method to increase the concentration of ions transmitted to mass spectrometers and other analyzers, both from volatile or involatile species in solution, hence increasing their analytical sensitivity. It also enables improved charging efficiencies of neutral volatile species existing in the gas phase.03-03-2011
20100096547Method for classifying and separating particles, and device for carrying out said method - In a method for classifying and separating particles in a fluid stream in which the particles are sprayed and electrically charged and deflected in an electrical field one portion of the stream of the charged or ionized particles respectively is introduced into a first separation device operated as an analyzer (04-22-2010
20100176291MASS SPECTROMETER - A mass analyzer system includes an ion inlet that receives a flow of ions, a multi-mode ion controller that controls some or all of the ions, and a multi-mode mass analyzer, in communication with the ion controller, that performs at least one of analyzing and controlling some or all of the ions. The system also includes a detector, in communication with the multi-mode mass analyzer, that detects some or all of the ions and a processor that controls the operation of at least one of the multi-mode ion controller and the multimode mass analyzer.07-15-2010
20090095901CHEMICAL IONIZATION REACTION OR PROTON TRANSFER REACTION MASS SPECTROMETRY WITH A QUADRUPOLE MASS SPECTROMETER - A system and methods are described for generating reagent ions and product ions for use in a quadrupole mass spectrometry system. A microwave or high-frequency RF energy source ionizes particles of a reagent vapor to form reagent ions. The reagent ions enter a chamber, such as a drift chamber, to interact with a fluid sample. An electric field directs the reagent ions and facilitates an interaction with the fluid sample to form product ions. The reagent ions and product ions then exit the chamber under the influence of an electric field for detection by a quadrupole mass spectrometer module. The system includes various control modules for setting values of system parameters and analysis modules for detection of mass values for ion species during spectrometry and faults within the system.04-16-2009
20120074313Microwave Cavity Detector for Mass Spectrometry - A detector for time of flight mass spectroscopy uses a microwave resonant cavity excited into resonance by the passage of charged particles as an ion detector. With proper configuration of the frequency of resonance of the cavity, its modes and its quality factor, nanosecond time resolution, should be possible.03-29-2012
20110303840MULTIPOLE ION GUIDE ION TRAP MASS SPECTROMETRY WITH MS/MSN ANALYSIS - A method includes directing ions from an atmospheric pressure ion source to a first ion guide; directing ions in the first ion guide to a second ion guide, the second ion guide being a multipole ion guide extending along an axis; periodically directing ions along the axis; receiving at least some of the ions in a time-of-flight analyzer; accelerating the ions in the time-of-flight mass analyzer orthogonal to the axis; and detecting the accelerated ions.12-15-2011
20100320376ION TRAP - An ion trap comprises substantially elongate electrodes 12-23-2010
20100237238PROTEIN SEQUENCING WITH MALDI MASS SPECTROMETRY - In a mass spectrometer, sample ions are produced by using matrix assisted laser desorption with a matrix substance that supports spontaneous, non-ergodic ISD fragmentation and a laser light source with nanosecond light pulses and a multiple spot beam profile. A plurality of individual time-of-flight spectra are recorded from the resulting ions in such a way that amplification of ion signals in the mass spectrometer detector is initially reduced so that only ions with masses near a mass range limit are initially recorded. During the repeated acquisitions of the individual time-of-flight spectra, both the detector amplification and the mass range limit are increased. By these methods, it is possible to evaluate c and z fragment ions in lower mass ranges and to directly read N-terminal sequences from near terminus up to 80 amino acids and beyond, and C-terminal sequences up to more than 60 amino acids.09-23-2010
20100237237TANDEM ION TRAPPING ARRANGEMENT - A mass spectrometer is disclosed comprising a first storage ion trap (09-23-2010
20110121174MASS SPECTROSCOPE AND MASS SPECTROMETRY - Provided is a mass spectroscope employing electron capture dissociation wherein the peak number of detectable fragment ions is increased. The mass spectroscope comprises an ion source (05-26-2011
20080296488IMAGING MASS SPECTROMETRY FOR SMALL MOLECULES IN TWO-DIMENSIONAL SAMPLES - The invention relates to spatially resolved mass spectrometric measurement and visualization of the distribution of small molecules in a mass range from approximately 150 to 500 Daltons, for example drugs and their metabolites, in thin sections or other two-dimensional samples, preferably with ionization of the molecules by matrix-assisted laser desorption. The invention includes the steps measuring a daughter ion produced by forced decomposition of the molecular ion instead of the ionized analyte molecule itself, the daughter ion having a much better signal-to-noise ratio. The daughter ions are detected in a relatively simple reflector time-of-flight mass spectrometer instead of using an expensive time-of-flight tandem mass spectrometers for the measurement of the daughter ions. Advantageously, substantially faster and less expensive scanning of the thousands of mass spectra which serve as the basis for visualizing the spatial distribution of the analyte molecule is achieved, while the mass resolution and sensitivity are at least equally good.12-04-2008
20100327159Ion Source Cleaning End Point Detection - In an ion implanter, a Faraday cup is utilized to receive an ion beam generated during ion source cleaning. The detected beam has an associated mass spectrum which indicates when the ion source cleaning process is complete. The mass spectrum results in a signal composed of a cleaning agent and the material comprising the ion source. This signal will rise over time as the ion source chamber is being cleaned and will level-off and remain constant once the deposits are etched away from the source chamber, thereby utilizing existing implant tools to determine endpoint detection during ion source cleaning.12-30-2010
20110036978INTRODUCTION OF IONS INTO MASS SPECTROMETERS THROUGH LAVAL NOZZLES - Ions entrained in a gas are transported into the vacuum system of an ion user, such as a mass spectrometer, from an ion source located outside the vacuum. The gas and ions pass through a nozzle that connects the ion source to the vacuum system and is shaped to form a supersonic gas jet in a first vacuum chamber of the vacuum system. In the first vacuum chamber, ions entrained in the supersonic gas jet are extracted electrically or magnetically and are collected, for example, by an RF ion funnel and transmitted to the ion user. The supersonic gas jet travels on and, after passing through the first vacuum chamber, the supersonic gas jet is directed into a separate pump chamber out of which the gas is pumped.02-17-2011
20110036977SENSITIVE ION DETECTION DEVICE AND METHOD FOR ANALYSIS OF COMPOUNDS AS VAPORS IN GASES - An ion mobility spectrometer (IMS) for the detection of trace gaseous molecular compounds dissolved or suspended in a carrier gas, particularly in ambient air, without preconcentration or the trapping of analyte particles. The IMS of the invention comprises an ionization volume of greater than 5 cm02-17-2011
20120267523Miniature toroidal radio frequency ion trap mass analyzer - A scaled down version of a toroidal radio frequency (RF) ion trap mass analyzer operating with RF trapping voltages on the order of 1 kV10-25-2012
20120267524APPARATUS AND METHOD FOR CONTROLLING A PIPELINE-TYPE ION CYCLOTRON RESONANCE MASS SPECTROMETER - The present invention relates to an apparatus and method for controlling a pipeline-type ion cyclotron resonance mass spectrometer, in which an ion trap unit of the ion cyclotron resonance mass spectrometer is capable of using two digitizers at the same time, thus enabling a measurement process for detecting an electrical signal which indicates the mass of ions corresponding to a specific purpose, and another measurement process for detecting another electrical signal which indicates the mass of ions corresponding to another specific purpose, to be simultaneously performed. Accordingly, it is an aim of the present invention to provide an apparatus and method to for controlling a pipeline-type ion cyclotron resonance mass spectrometer, which can overcome the problems of time delay among control procedures, and can present a signal detection step wherein an excitation electrode is utilized to improve the sensitivity and speed of signal detection.10-25-2012
20120326026PORTABLE ION TRAP MASS SPECTROMETER WITH METAL HYDRIDE CONTAINER AS SOURCE OF HYDROGEN BUFFER GAS - A mass spectrometry (MS) method which includes generating in a vicinity of the quadrupole ion trap hydrogen molecules, directing at least part of the hydrogen molecules into the quadrupole ion trap cell, applying AC and DC voltages to quadrupole ion trap cell electrodes to create a combined AC/DC trapping field, placing sample ions inside the quadrupole ion trap cell, cooling at least part of said ions using said hydrogen molecules as a buffer gas, changing the combined AC/DC trapping field to eject the ions from the quadrupole ion trap cell, and detecting the ejected ions12-27-2012
20100230588ION SELECTION APPARTUS AND METHOD - An ion mobility spectrometer or other ion apparatus has two or three grid electrodes 09-16-2010
20120326027MASS SPECTROMETRY METHOD - A mass spectrometry method that corrects the effects from space charge and that achieves both sensitivity and a dynamic range. The mass axis of the mass spectrum is corrected based on the counts of ions accumulated within the ion trap at the point in time each ion was extracted.12-27-2012
20120091334METHOD OF OPERATING TANDEM ION TRAPS - A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.04-19-2012
20130112869MASS SPECTROMETRY SYSTEM WITH MOLECULAR DISSOCIATION AND ASSOCIATED METHOD - A mass spectrometry system based on the general principle of accelerator mass spectrometry (AMS) is disclosed. An ion source (05-09-2013
20110210244PRACTICAL ION MOBILITY SPECTROMETER APPARATUS AND METHODS FOR CHEMICAL AND/OR BIOLOGICAL DETECTION - This invention describes an ion mobility spectrometer system for chemical detection in the field. The system allows: a high throughput operation, an interface to new ionization methods, and an interface to a mass spectrometer.09-01-2011
20110248159Ion cyclotron resonance mass spectrometer system and a method of operating the same - A measuring cell of an ICR mass spectrometer and a method of operating a measuring cell of the ICR mass spectrometer. The method and system trap ions in a first compartment of the ICR measuring cell by generating an electric potential well in the direction of the magnetic field with a minimum of the electric potential well located inside the first compartment. The method and system excite cyclotron motion of the ions trapped in the first compartment. The method and system transfer at least a part of the excited ions from the first compartment to a second compartment of the ICR measuring cell by displacement of a position of the minimum of the electric potential well from the first compartment to the second compartment. The ions are transferred by displacing the position of the minimum of the electric potential well from the first compartment to the second compartment preferably over a period of time equal to or longer than a characteristic period of ion oscillations along the direction of the magnetic field in the electric potential well. The method and system detect ion cyclotron motion of at least a part of the ions in the second compartment.10-13-2011
20120273673Selective Ion Mobility Spectrometer - Ions with a predetermined range of ion mobilities are produced by filtering input ions with at least two consecutive ion mobility high pass and/or low pass filters. Each ion mobility filter is formed by entraining ions in a moving gas and applying a DC electric field to the ions which causes the ions to move in a direction opposite to the gas flow. An ion mobility high pass filter is formed when the DC electric field drives the ions against the flow of gas, whereas an ion mobility low pass filter is formed when a the gas flow drives entrained ions against an DC electric field barrier.11-01-2012
20100314538Parallel Mass Analysis - A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.12-16-2010
20110297825MASS SPECTROMETRY METHOD FOR MEASURING VITAMIN B6 IN BODY FLUIDS - Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5′-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.12-08-2011
20130187042PERIODIC FIELD DIFFERENTIAL MOBILITY ANALYZER - A periodic field differential mobility analyzer apparatus for separating and identifying ionic analytes employs a series of elongated parallel channels, a pump, a first voltage providing an electric field E07-25-2013
20130193319METHOD FOR DETERMINING BORON ISOTOPIC COMPOSITION BY PTIMS - STATIC DOUBLE COLLECTION - A method for determining boron isotopic composition by PTIMS (Positive Thermal Ionization Mass Spectrometry)—static double collection realizes simultaneous static collection of m/e309 peak and m/e308 peak by double Faraday cups through adjusting the two parameters Focus Quad and Dispersion Quad in Zoom Optics, and completes high-accuracy determination of boron isotopic composition. The method includes (1) determining Focus Quad and Dispersion Quad parameters in the Zoom Optics of the ion source; (2) determining the two parallel cups in the Faraday collector and their parameters; (3) determining the collection mass number of the center cup of the Faraday collector. The method of the present invention establishes a method for determining boron isotopic composition by static collection with double Faraday cups under the condition of not changing high voltage parameters and Faraday cup hardware setting, greatly shortens data acquisition time compared to the dynamic peak jumping method, and improves the sensitivity and internal and external accuracy of the determination of boron isotopic composition by PTIMS.08-01-2013

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