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Of biological material (e.g., urine, etc.)

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205 - Electrolysis: processes, compositions used therein, and methods of preparing the compositions

205775000 - ELECTROLYTIC ANALYSIS OR TESTING (PROCESS AND ELECTROLYTE COMPOSITION)

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DocumentTitleDate
20090194432System and Methods for Determination of Analyte Concentration Using Time Resolved Amperometry - A method for determining a concentration of an analyte is disclosed. The method includes applying a potential excitation to a fluid sample containing an analyte and determining if a current decay curve associated with the fluid sample has entered an analyte depletion stage. The method also includes measuring a plurality of current values associated with the fluid sample during the analyte depletion stage and calculating an analyte concentration based on at least one of the plurality of current values.08-06-2009
20110186448DETECTION AND DISCRIMINATION OF TARGET DNA SEQUENCE AND SINGLE NUCLEOTIDE POLYMORPHISM DIRECTLY ON DOUBLE-STRANDED OLIGONUCLEOTIDE AND PCR PRODUCT WITHOUT DENATURATION OF DSDNA SAMPLE BASED ON PNA-DSDNA HYBRID AND UTILIZING PNA PROBE - A method of detection and discrimination of target DNA sequences and of single nucleotide polymorphisms (SNPs) directly on double-stranded DNA (dsDNA) samples without the need for denaturation of the target dsDNAs. This is achieved by the use of a PNA chain as a probe. This probe is self-assembled on a gold electrode; hybridization of the probe with the target dsDNA forms a PNA-dsDNA hybrid. The hybrid is then labeled with a mediator, and the PNA-dsDNA hybridization is monitored. Monitoring of the hybrid formation can be achieved using an electrochemical approach. This method is able to detect and discriminate target DNA sequences and SNPs on ds-oligonucleotides. Furthermore, this method is able to detect and discriminate target DNA sequences and SNPs on double-stranded PCR products.08-04-2011
20130075279MICROBIALLY-BASED SENSORS FOR ENVIRONMENTAL MONITORING - The present invention relates to the field of surface water monitoring. More specifically, the present invention provides low-cost, real-time bio-electrochemical sensors for surface water monitoring based on the metabolism of one or more electrogenic microbes.03-28-2013
20110192731METHODS FOR THE DETECTION AND DIAGNOSIS OF MALARIA USING AN ELECTROCHEMICAL SENSOR - Disclosed are apparatuses for detecting hemoglobin in patient samples. The apparatuses include a primary electrode and a reference electrode. The apparatus is configured to measure current or voltage generated between the primary electrode and the reference electrode in response a redox reaction catalyzed by hemoglobin. The apparatuses can detect a variety of hemoglobins, including dimeric hemoglobin associated with malaria. Also disclosed are biosensor systems including the apparatuses and methods of using the biosensor systems.08-11-2011
20100072080Functionalized Nanopipette Biosensor - Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific reaction withy peptide ligands chemically immobilized in the vicinity of the tip. Analytes which bind to the ligands cause a detectible change in ionic current. A sensitive detection circuit, using a feedback amplifier circuit, and alternating voltages is further disclosed. Detection of Il-10 at a concentration of 4 ng/nl is also disclosed, as is detection of VEGF.03-25-2010
20130026051BIOSENSOR - An electrode assembly that may be used, for example, for electrochemically analysing a sample to determine the presence (or otherwise) of a species having biomembrane activity comprises at least one working electrode comprised of a conductive carrier substrate having a surface coated with mercury immobilised on the surface of the substrate. The surface of the mercury remote from said substrate is coated with a phospholipid layer. The preferred carrier substrate is platinum. The electrode assembly may be incorporated in a flow cell.01-31-2013
20130081959In Vitro Analyte Sensor, and Methods - In vitro electrochemical sensor that provide accurate and repeatable analysis of a sample of biological fluid are provided. In some embodiments, the sensors have a measurement zone that has a volume less than the volume of the sample chamber. The measurement zone could have a volume of no more than about 0.2 μL.04-04-2013
20090045076SYSTEM AND METHOD FOR ANALYTE MEASUREMENT USING DOSE SUFFICIENCY ELECTRODES - A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.02-19-2009
20130087468SYSTEM AND METHOD OF SUB CLINICAL DETECTING MASTITIS - Mastitis in a milking animal is detected through sensing the capacitance effects in milk. Using frequencies of greater than 60 megahertz applied by a capacitance probe to milk as it streams through otherwise conventional milking equipment during milking, yields a reliably discernable shift in the phase angle, indicating the presence of mastitis.04-11-2013
20090301901ELECTROCHEMICAL DETECTION OF MAGNETIC PARTICLE MOBILITY - An exemplary embodiment of the invention may include a method for electrochemically monitoring the mobility of particles in a fluid in response to an external field, the method may include monitoring an electrical characteristic of the fluid in an electrochemical cell, the fluid comprising particles that can be moved under the influence of an externally applied field; observing changes in the electrical characteristic caused by particle movement induced by the external field; and inferring a change in the physical state of the fluid from a change in the magnitude of the electrical characteristic observed.12-10-2009
20120103836DETECTION DEVICE FOR DETECTING A TEST SUBSTANCE, ELECTRODE SUBSTRATE, WORKING ELECTRODE, INSPECTION TIP, METHOD OF DETECTING A TEST SUBSTANCE, AND METHOD OF DETECTING A SAMPLE SUBSTANCE - A detection device for detecting a test substance which is capable of detecting a test substance and a sample substance with high sensitivity, an electrode substrate, a working electrode, an inspection tip, a method of detecting a test substance, and a method of detecting a sample substance are provided in which a reflective part (reflective layer) is disposed on the working electrode so as to reflect excitation light emitted from a light source and passing through the working electrode toward the working electrode.05-03-2012
20120217173METHOD AND APPARATUS FOR MEASURING OXIDATION-REDUCTION POTENTIAL - Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.08-30-2012
20130056367Integrated sensing device and related methods - The present invention is generally directed to devices and methods for sensing a variety of biologically-related substances and/or chemical substances. In a device aspect, the present invention is directed to a multilayer device for sensing metal ions, non-biological molecules, biological molecules, or whole cells. In a method aspect, the present invention is directed to a method for sensing species such as ions, protons, metal ions, non-biological molecules, whole cells, and biological molecules, for example one or more biologically-related substances such as proteins, nucleic acids, DNA, RNA, enzymes, and chemical substances such as water contaminants.03-07-2013
20130213822ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS - The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.08-22-2013
20090294304Electrochemical sensor - A composition suitable for use in an electrochemical detection of ischeamia via albumin cobalt finding test (ACB), said composition comprising (i) a transition metal salt eg. Cobalt; (ii) an electrode area normalising agent having a current which is dependent on electrode area eg. RU (NH12-03-2009
20090283424SENSOR ELECTRODE AND METHOD FOR THE ELECTROCHEMICAL DETECTION OF NUCLEOTIDES - A sensor electrode for the detection of nucleotides in a biological sample is described. The sensitivity of the electrode is enhanced by the nanostructured sensor architecture that increases the available surface area of the electrode. The electrode detects nucleotides using standard electrochemical methods.11-19-2009
20110011752SYSTEMS AND METHODS FOR DISCRIMINATING CONTORL SOLUTION FROM A PHYSIOLOGICAL SAMPLE - Described herein are systems and methods for distinguishing between a control solution and a blood sample. In one aspect, the methods include using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or a control solution based on at least two characteristics. Further described herein are methods for calculating a discrimination criteria based upon at least two characteristics. Still further described herein are system for distinguishing between blood samples and control solutions.01-20-2011
20090145780ELECTRODE PLATE FOR ELECTROCHEMICAL MEASUREMENTS, APPARATUS FOR ELECTROCHEMICAL MEASUREMENTS HAVING THE ELECTRODE PLATE, AND PROCESS FOR QUANTITATIVELY DETERMINING TARGET SUBSTANCE USING THE ELECTRODE PLATE - An object of the invention is to provide an electrode plate for electrochemical measurements for detecting with high sensitivity and determining a substance included in a living body in a slight amount.06-11-2009
20090236237LIQUID SAMPLE MEASUREMENT METHOD AND APPARATUS - A liquid sample measurement apparatus of the present invention is provided with a timer (09-24-2009
20120234700SYSTEM AND METHODS FOR DETERMINATION OF ANALYTE CONCENTRATION USING TIME RESOLVED AMPEROMETRY - A method for determining a concentration of an analyte is disclosed. The method includes applying a potential excitation to a fluid sample containing an analyte and determining if a current decay curve associated with the fluid sample has entered an analyte depletion stage. The method also includes measuring a plurality of current values associated with the fluid sample during the analyte depletion stage and calculating an analyte concentration based on at least one of the plurality of current values.09-20-2012
20080296175SUBSYSTEMS AND METHODS FOR USE IN PATCH CLAMP SYSTEMS - Subsystems and methods for use in patch clamp systems are provided. For example, in certain embodiments, compensation circuitry is used to compensate for non-idealities present in the patch clamp system. The accuracy of this compensation may be verified by employing, for example, circuitry that models the patch clamp system.12-04-2008
20130161206METHODS OF USING AN ELECTROCHEMICAL BIOSENSOR - According to one embodiment of the present invention, an electrochemical sensor (06-27-2013
20100089775ELECTROCHEMICAL TEST STRIP, ELECTROCHEMICAL TEST SYSTEM, AND MEASUREMENT METHOD USING THE SAME - An electrochemical test strip, an electrochemical test system, and a measurement method using the same are provided. The electrochemical test strip includes an insulating substrate, an electrode system formed on the insulating substrate, and an insulating layer formed on the electrode system. The electrode system includes a set of measurement electrodes, a set of identifying electrodes, and a resistive path having a predetermined resistance value. The set of identifying electrodes is made of metal material, and the resistive path is made of non-metal material. The set of measurement electrodes includes a reference electrode and a working electrode insulated from each other, and the set of identifying electrodes includes a first identifying electrode and a second identifying electrode connected with each other through the resistive path. The insulating layer covers a part of the electrode system, wherein a part of the electrode system not covered by the insulating layer forms a reaction region with a supply port. When a sample is injected into the supply port of the reaction region, the injected sample reaches the set of measurement electrodes and the set of identifying electrodes in sequence.04-15-2010
20110278180Analyte Determination Method and Analyte Meter - The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.11-17-2011
20100252452APPARATUS AND METHOD FOR ELECTROCHEMICAL DETECTION - The present invention is directed to a sensor with opposing electrodes and test strips using this sensor. The invention can be used to measure blood or plasma coagulation in assays like prothrombin time (PT) and thrombin potential, for example, in point-of-care monitoring of anticoagulants.10-07-2010
20110297556NANOTUBE ELECTROCHEMISTRY - An electrode for electrochemical analysis is described, the electrode comprising: an insulating surface; a three-dimensional network of carbon nanotubes situated on the insulating surface; and an electrically conducting material in electrical contact with the carbon nanotubes; wherein the carbon nanotubes are oriented substantially parallel to the insulating surface. Also described is a method of manufacturing the electrode, and a method of electrochemically analysing a solution using electrodes of this type, and an associated assay device or kit.12-08-2011
20110139638Use of Polyoxyalkylene Nonionic Surfactants with Magnesium Ion Selective Electrodes - Methods are disclosed for reducing the shift in EMF bias in a magnesium ion selective electrode, comprising the step of: contacting the electrode with a composition comprising a polyoxyalkylene nonionic surfactant; wherein the polyoxyalkylene nonionic surfactant has an HLB greater than about 18. Additional aspects of the present invention are directed to methods, comprising the steps of: contacting a magnesium ion selective electrode with a composition comprising a polyoxyalkylene nonionic surfactant, wherein the polyoxyalkylene nonionic surfactant has an HLB greater than about 18; and measuring a biologically relevant level of a blood electrolyte in a blood composition with the electrode. In certain embodiments, the polyoxyalkylene nonionic surfactant is polyoxy ethylene (100) stearyl ether and the blood electrolyte is magnesium ion.06-16-2011
20090283426METHOD FOR FABRICATING PATTERN ON A BIOSENSOR SUBSTRATE AND BIOSENSOR USING THE SAME - The present invention relates to a method for fabricating a pattern on a biosensor substrate and a biosensor using the same. The present invention provides a method of fabricating a pattern on a substrate of a biosensor in which an amine group is formed on a substrate by using polyethylenimine (PEI), and a site to which a biosubstance is immobilized is masked and irradiated with ultraviolet rays, such that a pattern having a desired shape can be formed on the substrate and a biosensor in which the biosubstance is immobilized on the pattern acquired by using the above-mentioned method.11-19-2009
20110031135METHOD AND APPARATUS FOR BIOCHEMICAL SENSOR ARRAY WITH INTEGRATED CHARGE BASED READOUT CIRCUITRY - A MEMS biochemical sensor configured to sense a target molecule, such as a DNA molecule, a protein molecule, and a viruses molecule. In one embodiment, the biochemical sensor may include a cell and a readout module. The cell is configured to be coupled to a probe molecule, to retain a pre-sensing charge before the probe molecule is exposed to the target molecule, and to retain a sensing charge after the probe molecule is exposed to the target molecule. The readout module is coupled to the cell and configured to generate a measurement signal based on the pre-sensing charge and the sensing charge.02-10-2011
20110290673Method for Determination of Analyte Concentrations and Related Apparatus - A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.12-01-2011
20110297557Underfill Management System for a Biosensor - A biosensor system including the underfill management system determines the analyte concentration in a sample from the at least one analytic output signal value. The underfill management system includes an underfill recognition system and an underfill compensation system. The underfill recognition system determines whether the test sensor initially is substantially full-filled or underfilled, indicates when the sample volume is underfilled so that additional sample may be added to the test sensor, and starts or stops the sample analysis in response to the sample volume. The underfill recognition system also may determine the initial degree of underfill. After the underfill recognition system determines the initial fill state of the test sensor, the underfill compensation system compensates the analysis based on the initial fill state of the test sensor to improve the measurement performance of the biosensor system for initially underfilled test sensors.12-08-2011
20100181211ELECTROCHEMICAL SENSOR AND BIOSENSOR AND METHOD OF ELECTROCHEMICAL MEASUREMENT - The invention relates to an electrochemical sensor or biosensor that contains a substrate which bears at least one working electrode and a heating element, optionally also a temperature measuring element. This electrochemical sensor or biosensor allows to achieve better mass transport towards the working electrode during the measurement process. The invention further relates to a method of electrochemical measurement using the sensor or biosensor of the invention.07-22-2010
20090184006METHOD FOR THE DETERMINATION OF THE ACTIVITY OF THE ORGANIC CATION TRANSPORTER - The present invention refers to a method for determining the activity of the organic cation transporter (OCT), a method for determining the activity of or identifying a chemical compound that modulates the activity of OCT with the help of a cell free electrophysiological sensor chip containing a solid-supported sensor electrode and a lipid layer containing the OCT located in the immediate spatial vicinity to the sensor electrode, whereas the sensor electrode is electrically insulated relative to the solutions used and to the lipid layer, as well as to the sensor chip itself and a kit containing same.07-23-2009
20100032321ELECTROCHEMICAL BIOSENSOR MEASURING SYSTEM - Disclosed is an electrochemical biosensor measuring device which can be used together with an electrochemical biosensor. The biosensor measuring device comprises an electrical connection portion which is electrically connected with the electrodes of the biosensor upon the insertion of the biosensor there into, and a connector having a structure in which at least one light absorption or reflection path sequentially comprising a light emitter-production lot information identification portion-detector unit is provided to identify the production lot information recorded in the biosensor. The electrochemical biosensor measuring device can automatically identify the production lot information of the biosensor, encoded in the form of a hue or hole marks, upon the insertion of the electrochemical biosensor into the measuring device, thereby obviating the need to manually input the production lot information of the biosensor. Thus, inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.02-11-2010
20110215004Measuring device and methods for use therewith - The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.09-08-2011
20090152131System and Method of Examining Trace Organic Matters In Living Being's Urine - A method and a system of examining trace organic matter in urine are provided. The system includes a polarograph having a graphite electrode and a metal electrode; a data examining device having a memory device stored with a standard determination module, a comparison module and a display device for operating interface and displaying results. The examining method is to utilize a polarograph for examining living being's urine and store the polarogram produced by the polarograph in memory device. Then utilizing a comparison module to process comparison of the graph data of a polarogram with a standard determination module to examine the composition and quantity of an organic matter in urine, and displaying the result on a display device.06-18-2009
20090145779Rapid-Read Gated Amperometry - A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Input signals including multiple duty cycles of sequential excitation pulses and relaxations are input to the sample. One or more signals output from the sample within 300 ms of the input of an excitation pulse may be correlated with the analyte concentration of the sample to improve the accuracy and/or precision of the analysis. Determining the analyte concentration of the sample from these rapidly measured output values may reduce analysis errors arising from the hematocrit effect, mediator background, and other error sources.06-11-2009
20090120810ANALYTE MONITORING SYSTEM CAPABLE OF DETECTING AND PROVIDING PROTECTION AGAINST SIGNAL NOISE GENERATED BY EXTERNAL SYSTEMS THAT MAY AFFECT THE MONITORING SYSTEM - An analyte monitoring system includes a biosensor for detecting an analyte concentration in blood. The monitoring system includes a sensor for sensing whether tool or other piece of equipment is producing electrical noise that may affect operation of the biosensor. If such electrical noise is detected, the system isolates the biosensor during the period of detected operation of the other tool or equipment. In some embodiments, the system measure both signal noise in and temperature of the environment surrounding the biosensor to determine whether another tool or other piece of equipment is currently in operation. The system may also include an auxiliary power source to maintain the biosensor in a biased state during the period when the biosensor is placed in isolation.05-14-2009
20090294305Method for Specifically Detecting Analyte Using Photocurrent, and Electrode, Measuring Cell and Measuring Device for Use Therein - A method, an electrode, a measuring cell, and a measuring device are disclosed which can detect and quantitatively determine an analyte having specific bonding properties, in a highly sensitive, simple and accurate manner using photocurrent. This method comprises contacting a working electrode and a counter electrode with an electrolyte medium, wherein the working electrode has an analyte immobilized thereon through a probe substance and wherein the analyte is bonded to a sensitizing dye; irradiating the working electrode with light to photoexcite the sensitizing dye; and detecting photocurrent flowing between the working electrode and the counter electrode, wherein the photocurrent is generated by transfer of electrons from the photoexcited sensitizing dye to the working electrode. The working electrode comprises an electron accepting layer comprising an electron accepting substance capable of accepting electrons released from the sensitizing dye in response to photoexcitation, wherein the probe substance is supported on a surface of the electron accepting layer. The electron accepting substance is an oxide semiconductor having an energy level lower than that of a lowest unoccupied molecular orbit (LUMO) of the sensitizing dye. The electrolyte medium comprises an electrolyte and at least one solvent selected from an aprotic solvent and a protic solvent, wherein the electrolyte comprises a salt capable of providing an oxidized sensitizing dye with electrons.12-03-2009
20120187001HAND-HELD TEST METER WITH DEEP POWER CONSERVATION MODE VIA DIRECT OR GENERATED SIGNAL APPLICATION AND METHOD FOR EMPLOYING SUCH A METER - A hand-held test meter for use with an analytical test strip in the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a housing, a buttons electrical circuit block, at least one user operable button in operable communication with the buttons electrical circuit block, a microcontroller block, and a first-time-on (FTO) electrical circuit block. The FTO electrical circuit block is disposed within the housing and includes an activation node and a signal reception contact. In addition, the FTO electrical circuit block is configured to place the hand-held test meter into a deep power conservation mode upon either the direct application of an electrical signal to the activation node by an external device (e.g., a manufacturing tester) or a deactivation signal received at the signal reception contact. The FTO electrical circuit block is also configured to terminate the deep power conservation mode and place the hand-held test meter into a normal operating mode upon receiving a predetermined user triggered signal from the at least one user operable button. Moreover, the microcontroller block is configured to generate the deactivation signal received at the signal reception contact in response to an external command signal received by the microcontroller block.07-26-2012
20110266161SYSTEMS AND METHODS FOR INTEGRATED DETECTION - An integrated sensor is capable of detecting analytes using electrochemical (EC), electrical (E), and optical (O) signals or EC and O signals. The sensor introduces synergetic new capabilities and enhances the sensitivity and selectivity for real-time detection of an analyte in complex matrices, including the presence of high concentration of interferences in liquids and in gas phases.11-03-2011
20110168577ESD PROTECTION FOR BIOSENSORS - A biosensor assembly includes a fluidic system. A biosensor is positioned for direct contact with a fluid as the fluid flows through the fluidic system. An electrostatic discharge (ESD) electrode provides ESD protection for the biosensor. The ESD electrode can be engaged while the fluidic system of the assembly is primed, and then disengaged to prevent leakage currents from the fluid while the biosensor is in operation.07-14-2011
20130098780SENSING AND SENSORS - A sensor system comprising a substrate and integrated onto the substrate an array (04-25-2013
20090288963METHOD AND APPARATUS FOR MANIPULATING SINGLE CELLS AND SMALL AGGREGATES THEREOF - A well, in particular an open well (11-26-2009
20090294306REFERENCE ELECTRODES HAVING AN EXTENDED LIFETIME FOR USE IN LONG TERM AMPEROMETRIC SENSORS - The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.12-03-2009
20090294307REDOX POLYMER BASED REFERENCE ELECTRODES HAVING AN EXTENDED LIFETIME FOR USE IN LONG TERM AMPEROMETRIC SENSORS - The present application provides redox polymer based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.12-03-2009
20090288964BIOSENSOR WITH CODED INFORMATION AND METHOD FOR MANUFACTURING THE SAME - An electrochemical test sensor and method for forming the same for determining the concentration of an analyte in a fluid sample includes a base, a reagent layer, a lid, and a meter contact area that has a plurality of contacts. The meter contacts have a first testing contact, a second testing contact, and at least four coding contacts. At least a first electrical connection forms between the first testing contact and a first one of the plurality of coding contacts. At least a second electrical connection forms between the second testing contact and a second one of the plurality of coding contacts. A plurality of electrical connections forms or are severed between the plurality of adjacent coding contacts. At least one of the connections in the meter contact area is terminated or formed to encode calibration information on the test sensor.11-26-2009
20110198241BIOLOGICAL COMPONENT-MEASURING DEVICE AND METHOD FOR CALIBRATING THE SAME - This invention provides a biological component-measuring device, enabling the operator to easily calibrate the entire device and capable of measuring biological components accurately, and a method for calibrating the device. The device measures a sample including a body fluid taken through a body fluid sampler by sending it with a pump through a sample channel to a sensor. The device further includes a calibrating liquid channel through which a calibrating liquid can be supplied to the sensor via the sample channel by a switching of a first flow path changeover valve placed in the sample channel at a location upstream of the pump and connected to the channel. The method includes introducing the calibrating liquid in the calibrating liquid channel, via other channels, into the sensor by switching the valve.08-18-2011
20090166225Method and Apparatus for Assay of Electrochemical Properties - The presence of a select analyte in the sample is evaluated in an an electrochemical system using a conduction cell-type apparatus. A potential or current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes After the gradient is established, the applied potential or current is discontinued and an analyte-independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte-dependent signal obtained during application of the potential or current. This correction allows an improved measurement of analyte concentration because it corrects for device-specific and test specific factors such as transport (mobility) of analyte and/or mediator, effective electrode area, and electrode spacing (and as a result, sample volume), without need for separate calibration values. The analysis can be performed using disposable test strips in a hand held meter, for example for glucose testing.07-02-2009
20130118921Analyte Determination Method and Analyte Meter - The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.05-16-2013
20090272657DEVICES AND PROCESSES FOR ANALYZING NUCLEIC ACID DAMAGE AND REPAIR USING ELECTROPHORESIS - Systems, methods, and devices are provided for assessing DNA damage and repair in cells by measuring DNA migration under electrophoresis. In one exemplary embodiment, a microarray configured to hold cells in a predetermined spatial relationship is employed to improve accuracy, speed, and reliability of such measurements. In another embodiment, a self-contained cassette having a matrix material disposed therein can be used to create a substantially uniform environment for analyzing DNA damage and repair. Fluid can be circulated through the cell to assist in creating spatial patterns on the matrix material, or alternatively, the matrix material can already include a microarray pattern disposed thereon. Various methods and systems that take advantage of such microarrays and cassettes are also provided.11-05-2009
20080272007METHOD OF MAKING AN ELECTROCHEMICAL SENSOR - A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.11-06-2008
20080257754METHOD AND APPARATUS FOR ENTRY OF SPECIMENS INTO A MICROFLUIDIC DEVICE - A microfluidic device for analyzing biological samples is provided with a sample inlet section including an inlet port, a capillary passageway communication with the inlet port and with an inlet chamber. The inlet chamber includes means for uniformly distributing the sample liquid across the inlet chamber and purging the air initially contained therein.10-23-2008
20090026094Two-pulse systems and methods for determining analyte concentration - Methods and systems for determining the concentration of a analyte in a physiological fluid are provided. The method includes applying at least one first pulse at a first potential and at least one second pulse at a second potential to a sample solution containing an analyte, wherein the first potential and the second potential can be the same polarity and the second potential can be larger than the first potential. The method also includes measuring at least one first current-transient associated with the at least one first pulse and at least one second current-transient associated with the at least one second pulse, determining a ratio between at least one said first current-transient and at least one said second current-transient, wherein said current-transients are measured at a substantially common sampling-time, and determining an analyte concentration of the sample solution based on the ratio of said current-transients.01-29-2009
20090084687SYSTEMS AND METHODS OF DISCRIMINATING CONTROL SOLUTION FROM A PHYSIOLOGICAL SAMPLE - Methods for distinguishing between an aqueous non-blood sample (e.g., a control solution) and a blood sample are provided herein. In one aspect, the method includes using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or an aqueous non-blood sample based on at least two characteristics (e.g., amount of interferent present and reaction kinetics). The method can also include calculating a discrimination criteria based upon at least two characteristics. Various aspects of a system for distinguishing between a blood sample and an aqueous non-blood sample are also provided herein.04-02-2009
20090084688SOLID STATE DEVICE - A system that incorporates teachings of the present disclosure may include, for example, a solid-state selector having a vessel for carrying a liquid medium with one or more molecules surrounded by ions, a solid state conductive structure doped with impurities having one or more through-holes extending between two surfaces of the solid state conductive structure positioned within the liquid medium of the vessel, a voltage source coupled to the solid state conductive structure to selectively stimulate the ions surrounding the one or more molecules to pass through the one or more through-holes. Additional embodiments are disclosed.04-02-2009
20110139636GOLD-PLATED SCREEN-PRINTED ELECTRODES AND THEIR USE AS ELECTROCHEMICAL SENSORS - This disclosure describes a gold-plated screen-printed electrode for use as an electrochemical sensor.06-16-2011
20090084686Biosensor comprising interdigitated electrode sensor units - The present invention is related to a biosensor for detecting presence and concentration of various bio-materials such as genes and proteins by the electrical method, an interdigitated electrode sensor unit for forming the biosensor and a method for measuring concentration of a bio-material using the biosensor. The biosensor according to the present invention comprises a plurality of (a) independently-operating interdigitated electrode sensor units integrated on a substrate, wherein each interdigitated electrode sensor unit comprise: first electrode and second electrode formed interdigitatedly and spaced from each other on the substrate; and a sensor-immobilized biomolecule receptor immobilized on the substrate exposed between the first electrode and the second electrode so that the first electrode is electrically connected to the second electrode upon binding to a biomolecule and specifically binding to the biomolecule, wherein the biomolecule is analyzed by the number of the (b) interdigitated electrode sensor units electrically connected by the biomolecule captured by the sensor-immobilized biomolecule receptor.04-02-2009
20110139635ELECTROCHEMICAL BIOSENSOR STRIP AND METHOD FOR IDENTIFYING A CORRESPONDING BIOSENSING DEVICE BY SAID STRIP - The present invention relates to an electrochemical biosensor strip comprising a base which has a front side and a back side, an electrode system on the front side of said base, a code-recognition element on one end of the back side of said base, a cover which is located on said electrode system, and a reaction area which is in touch with said electrode system for a reaction to take place. By forms of said code-recognition element provided in the present invention, a biosensing device will automatically choose a specific set of calibration code corresponding to a particular batch of the electrochemical biosensor strip while coupling to the strip. Hence, the present invention eliminates the calibration step carried out by users and simplifies the measuring procedure, avoiding the inaccurate results due to the omission or improper operation of the calibration step by users. The present invention further relates to a method for identifying a corresponding biosensing device by using a ratio of lengths of each length-changeable area of the strip.06-16-2011
20090205979Electrolyte-Containing Sheet For Use In Specific Detection Of Analyte Using Photocurrent - There is disclosed an electrolyte medium which makes it possible to significantly simplify device structure and detection procedure as well as to detect photocurrent with high sensitivity and accuracy, in specific detection of an analyte with use of photocurrent generated by photo-excitation of a sensitizing dye. The electrolyte-containing sheet comprises a hydrous substrate; and an electrolyte contained in the hydrous substrate. The electrolyte-containing sheet is used as an electrolyte medium in specific detection of an analyte with use of photocurrent generated by photo-excitation of a sensitizing dye. A gel matrix or a water-absorbent substrate can be used as the hydrous substrate.08-20-2009
20100200432METHOD AND APPARATUS FOR DETERMINING SUBSTRATE CONCENTRATION AND REAGENT FOR DETERMINING SUBSTRATE CONCENTRATION - The present invention relates to a method, a reagent and an apparatus for determining a substrate concentration based on an amount of hydrogen peroxide generated from a substrate. In the present invention, a suppressing agent for suppressing a reaction between the hydrogen peroxide and an inhibitor is added. As the suppressing agent, an azide compound such as sodium azide or a nitrite compound such as sodium nitrite is used. In the invention, a supporting electrolyte, such as sodium chloride or potassium chloride may be further added.08-12-2010
20100170807SYSTEM AND METHOD FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A SAMPLE FLUID - The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 2.0 seconds or less, and/or having a clinically low Total System Error.07-08-2010
20090078588ELECTROCHEMICAL QUANTITATIVE ANALYSIS SYSTEM AND METHOD FOR THE SAME - A system for electrochemical quantitative analysis is provided. The system includes a measuring apparatus having a plurality of analysis modes. Each of the analysis modes is for quantitatively analyzing different biochemical substance. The system further includes a plurality of test strips. Each of the test strips has a different identification component for a different analysis mode. When one of the plurality of test strips is selected to electronically connect to the measuring apparatus, the measuring apparatus executes one of the plurality of analysis modes according to the identification component of the selected test strip to quantitatively analyze a corresponding biochemical substance.03-26-2009
20090078589SUBSYSTEMS AND METHODS FOR USE IN PATCH CLAMP SYSTEMS - Subsystems and methods for use in patch clamp systems are provided. For example, in certain embodiments, compensation circuitry is used to compensate for non-idealities present in the patch clamp system. The accuracy of this compensation may be verified by employing, for example, circuitry that models the patch clamp system.03-26-2009
20100193378IMPEDIMETRIC SENSOR AND APPLICATIONS THEREOF - The invention relates to a highly sensitive impedimetric sensor in which the highly conductive electrodes are separated by a barrier of insulating material. Said sensor is used to determine directly the presence of analytes in a biological sample of human, veterinary or environmental origin.08-05-2010
20100276303METHOD FOR MEASURING HEMATOCRIT VALUE OF BLOOD SAMPLE, METHOD FOR MEASURING CONCENTRATION OF ANALYTE IN BLOOD SAMPLE, SENSOR CHIP AND SENSOR UNIT - A voltage is applied across a counter electrode and a working electrode while an oxidant of a redox substance is in contact with the counter electrode and is not substantially in contact with the working electrode, and thereby metal that readily undergoes electrolytic oxidation forming at least part of a surface of the working electrode is oxidized while the oxidant in contact with the working electrode is reduced, such that a current produced upon the oxidation and the reduction is measured. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, a hematocrit value of a blood sample can be measured stably with satisfactory detection sensitivity. This measurement can be carried out, for example, with a sensor chip comprising a working electrode 11-04-2010
20100252453CONTROL SOLUTION FOR DETERMINING PERFORMANCE OF ELECTROCHEMICAL SENSING SYSTEM AND METHOD FOR THE SAME - A control solution for determining the performance of an electrochemical sensing system for measuring the concentration of an analyte in a body fluid sample and methods using the same are provided. The control solution contains the analyte at a predetermined amount and an alcohol-containing adjustor. The control solution generates a current signal from the electrochemical sensing system when the performance of the electrochemical sensing system is qualified and obtains a measured concentration corresponding to the current signal, wherein the measured concentration is less than the real concentration corresponding to the predetermined amount.10-07-2010
20100243482Biological specimen of electron microscope - The invention relates to a method and apparatus for forming the biological specimen of electron microscope. The invention carries out the rapid freezing and the cryogenic electrochemical doping to the biological specimen, so that the biological specimen has the behavior close to the conductor, which can be used to achieve the observation of biomolecules at a higher resolution using electron microscope. The invention will reduce the radiation damage of the biomolecules and the surrounding amorphous ice under electron beam irradiation, and the invention will clearly observe the prototype of the biomolecules.09-30-2010
20100243481Method and apparatus for measuring sample reaction results on biosensor - Disclosed is a method of measuring sample reaction results on a biosensor having a working electrode and other electrodes, including: applying voltage between the working electrode and each of the other electrodes and detecting the amount of current flowing through the working electrode to determine whether or not a sample is injected; applying voltage between the working electrode and one of the other electrodes and re-detecting the amount of current flowing through the working electrode; and acquiring and displaying a concentration value as a sample reaction result corresponding to the amount of detected current.09-30-2010
20100252454Method of measuring quantity of substrate - A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.10-07-2010
20110056848ELECTROCHEMICAL TEST SENSOR - An electrochemical test sensor for detecting the concentration of an analyte in a fluid sample. The electrochemical test sensor includes a housing that has a first end and a second opposing end. The housing includes an opening at the first end to receive a fluid test sample. An electrode assembly includes a substrate, a working electrode, a counter electrode and a reagent. The substrate has a first surface and an opposing second surface. The working electrode is disposed on the first surface of the substrate, and the counter electrode is disposed on the second surface of the substrate. The electrode assembly is positioned within the housing to define a reaction channel. The electrochemical test sensor may be used with a removable lancet mechanism or integrated within a lancet mechanism to form one integral unit.03-10-2011
20090283425Microelectrode Array System With Integrated Reference Microelectrodes To Reduce Detected Electrical Noise And Improve Selectivity Of Activation - A microelectrode array system used to sense physiological signals and stimulate physiological tissue to form signals is disclosed. The array includes a dielectric substrate and a two dimensional array of signal microelectrodes substantially perpendicular to and integrated on the dielectric substrate. At least one reference microelectrode is located adjacent to and integrated with the signal microelectrodes on the dielectric substrate. The reference microelectrodes are positioned on the dielectric substrate relative to the signal microelectrodes to enable a reduced level of electrical noise to be detected between the reference microelectrodes and the recording microelectrodes.11-19-2009
20120228160BIOSENSOR, BIOSENSOR CHIP AND BIOSENSOR DEVICE - A biosensor includes a working electrode 09-13-2012
20110233074Biosensors and Methods of Preparing Same - A biosensor strip having a low profile for reducing the volume of liquid sample needed to perform an assay. In one embodiment, the biosensor strip includes an electrode support; an electrode arrangement on the electrode support; a cover; a sample chamber; and an incompressible element placed between the cover and the electrode support, the incompressible element providing an opening in at least one side or in the distal end of the sample chamber to provide at least one vent in the sample chamber. In another embodiment, the biosensor strip has an electrode support; an electrode arrangement on the electrode support; a cover; and a sample chamber, the cover having a plurality of openings formed therein, at least one of the openings in register with the sample chamber. The invention further includes methods for preparing such a biosensor strips in a continuous manner.09-29-2011
20100300899Active CMOS Sensor Array For Electrochemical Biomolecular Detection - Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four active sensor array for multiplexed electrochemical biomolecular detection in a standard 0.25-μm CMOS process. Integrated potentiostats, including control amplifiers and dual-slope ADCs, stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site resulting from biomolecular reactions occurring on the chip surface. Post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand operation in harsh electrochemical environments are described. Demonstrations showing example operation of the active CMOS array for biomolecular detection include cyclic voltammetry of a reversible redox species, DNA probe density characterization, and quantitative and specific DNA hybridization detection in real time.12-02-2010
20110108440Underfill Recognition System for a Biosensor - A biosensor with an underfill recognition system assesses whether to analyze a sample for one or more analytes in response to the volume of the sample. The underfill recognition system applies polling and test excitation signals to the sample. The polling signals generate one or more polling output signals, which maybe used to detect when a sample is present and to determine whether the sample has sufficient volume for analysis. The test excitation signal generates one or more test output signals, which may be used to determine one or more analyte concentrations in the sample.05-12-2011
20110024309METHOD FOR DETECTING BIOMOLECULES ELECTRICALLY AND BIOCHIP THEREFOR - The present invention relates to a method for detecting the presence and/or the reaction of a biomolecule by monitoring changes of electrical property accurately according to the biological, biochemical or chemical reaction of the biomolecule, and a biochip provided for this purpose. The present invention provides a method for detecting the presence and/or the reaction of a biomolecule in a target sample, wherein the reaction of the target sample is performed under known reaction solution, in which a reference fluid having a high dielectric constant such as water is filled into a reaction chamber before the reaction to measure an impedance value or a capacitance value, after completing the reaction, the reaction solution is removed and said reference fluid having a high dielectric constant is refilled to measure an impedance value or a capacitance value, and then the impedance value or the capacitance value measured before and after the reaction is compared with each other.02-03-2011
20110042241Electrochemical Assays - A fluid assay system comprises a swab having an absorbent portion for receiving and retaining a fluid sample. The system also comprises an electrode module having at least one electrode, arranged so that it can be selectively placed over the absorbent portion of the swab in order to contact the electrode with the fluid sample. The system further comprises a reader module configured to process signals from the electrode module, with the electrode and reading modules arranged such that they can be coupled together for communication of the signals from the electrode module to the reader module.02-24-2011
20090065372METHOD FOR THE ELECTROCHEMICAL DETECTION OF TARGET NUCLEIC ACID SEQUENCES - The invention relates to a method and a collection for the electrochemical detection of target nucleic acid sequences. According to the method, a biological sample that may contain a nucleic acid is provided, said nucleic acid being capable of containing a target sequence, said biological sample being mixed with an oxidizing agent, said target sequence comprising at least one nucleotide base that can be oxidized by said oxidizing agent; complementary means capable of coupling with said target sequence are provided; according to the invention, said complementary means comprise activatable amplification means suitable for replicating said target sequence, said amplification means comprising at least nucleotides which include said nucleotide base, wherein said nucleotides are able to be consumed during replication so as to constitute replicated nucleic acids; and the presence of said target sequence is determined by applying an electric field to said sample and recording the decrease in the electric current.03-12-2009
20100133122INSTRUMENT AND SYSTEM FOR PHARMACOLOGIC MEASUREMENT AND WELL VESSEL USED THEREIN - An instrument is provided for pharmacologic measurement capable of detecting a very small and short time change in electric signal caused by a pharmacologic action of a biologic specimen with quickness and a high sensitivity by steeply decreasing an external disturbance component mixed into the system while dropping/exchange of medicinal solutions is conducted in a batch mode. The pharmacologic measurement instrument detects a change in electric signal caused by a pharmacologic action or electrophysiologic action of a biologic specimen, and includes an electrically conductive box having an opening section at the top surface thereof and a well vessel disposed in the opening section thereof, wherein the well vessel includes a base having recesses in which the biologic specimens are put; measurement electrodes formed on the bottom surfaces of the respective recesses; and reference electrodes electrically insulated from the respective measurement electrodes, and the reference electrodes together with the electrically conductive box electrostatically shields the well vessel.06-03-2010
20100187133CAPACITIVE MORPHOLINO DIAGNOSTICS FOR ANALYSIS OF NUCLEIC ACIDS - Surface hybridization, a reaction in which nucleic acid molecules in solution react with nucleic acid partners immobilized on a surface, is widely practiced in life science research. In these applications the immobilized partner, or “probe”, is typically single-stranded DNA. Because DNA is strongly charged, high salt conditions are required to enable binding between analyte nucleic acids (“targets”) in solution and the DNA probes. High salt, however, compromises prospects for label-free monitoring or control of the hybridization reaction through surface electric fields, as well as stabilizes secondary structure in target species that can interfere with probe-target recognition. In this work, initial steps toward addressing these challenges are taken by introducing Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports can be fabricated with methods similar to those employed with DNA, and are shown to hybridize efficiently and sequence-specifically with target strands. Hybridization-induced changes in the interfacial charge organization are analyzed with electrochemical methods and compared for Morpholino and DNA probe monolayers. Molecular mechanisms connecting surface hybridization state to the interfacial capacitance are identified and interpreted through comparison to numerical Poisson-Boltzmann calculations. Interestingly, positive as well as negative capacitive responses (contrast inversion) to hybridization are possible, depending on surface populations of mobile ions as controlled by the applied potential. Quantitative comparison of surface capacitance with target coverage (targets/area) reveals a near-linear relationship, and demonstrates sensitivities (limits of quantification) in the pg mm07-29-2010
20110079522MULTI-ANALYTE TEST STRIP WITH INLINE WORKING ELECTRODES AND SHARED OPPOSING COUNTER/REFERENCE ELECTRODE - A co-facial multi-analyte test strip includes a first insulating layer with an electrically conductive layer disposed thereon. The electrically conductive layer includes a first working electrode with a first analyte contact pad and a second working electrode with a second analyte contact pad. In addition, the first and second working electrodes of the electrically conductive layer are disposed on the first insulating layer in a planar inline configuration. The multi-analyte test strip also includes a patterned spacer layer positioned above the electrically conductive layer, with the patterned spacer layer defining a single bodily fluid sample-receiving chamber therein that overlies the first working electrode and the second working electrode. The multi-analyte test strip further includes a shared counter/reference electrode layer overlying and exposed to the bodily-fluid sample receiving chamber and configured in an opposing relationship to the first and second working electrodes; and a second insulating layer disposed above the shared counter/reference electrode layer. Moreover, the co-facial multi-analyte test strip also has a multi-analyte reagent layer disposed on the electrically conductive layer with the multi-analyte reagent layer having a first analyte reagent portion disposed on the first working electrode within the sample-receiving chamber and a second analyte reagent layer disposed the second working electrode within the sample-receiving chamber.04-07-2011
20110083974Method and apparatus for monitoring alteration of flow characteristics in a liquid sample - A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.04-14-2011
20110240489Analyte Determination Method and Analyte Meter - The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.10-06-2011
20090321281METHOD OF MEASURING BLOOD COMPONENT AND SENSOR USED IN THE METHOD - A sensor for blood component analysis that can correct the effect of a hematocrit easily is provided. The sensor includes an analysis portion including a working electrode, a counter electrode, and a reagent portion. The reagent portion includes an oxidoreductase that reacts with the blood component and a mediator, and the blood component is measured by causing a redox reaction between the blood component and the oxidoreductase in the presence of the mediator and detecting a redox current generated by the redox reaction by the working electrode and the counter electrode. In this sensor, the reagent portion further includes a hemolyzing agent (e.g., sodium cholate) for hemolyzing an erythrocyte, and when detecting the redox current, the erythrocyte is hemolyzed with the hemolyzing agent so as to cause hemoglobin released to an outside of the erythrocyte to react with the mediator and a current generated by this reaction also is detected to correct an effect of a hematocrit.12-31-2009
20100012530MEASUREMENT DEVICE AND SENSOR EJECTION METHOD - A measurement device of the present invention is provided with a sensor holding part (01-21-2010
20110174638MONITORING DEVICE AND MONITORING METHOD - A monitoring device which measures numerical value information on a subject substance in a body fluid has an electrochemical sensor including a sensor unit for detecting the subject substance which is used in the way of being embedded subcutaneously and generating an electric signal correlating to the numerical value information on the subject substance, and a temperature control unit which adjusts the detected ambient temperature as a temperature ambient to a sensor unit when detecting the subject substance so as to reach a target setting temperature when measuring the subject substance.07-21-2011
20110174637ELECTRODE LAYOUT FOR BLOOD TEST SENSOR STRIP - An improved electrode layout for a continuous strip sensor is provided which reduces misalignment of the electrodes with the contacts which read the position of the strip. Better contact with the electrodes reduces or eliminates transient signals between stop positions of the sensor strip.07-21-2011
20100126884Analyte Sensor with Insertion Monitor, and Methods - A sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector.05-27-2010
20110068015BIOSENSOR AND METHOD OF DRIVING THE SAME - Provided are a biosensor and a method of driving the same. The biosensor includes a transistor including a substrate including a source, a drain, and a channel formed between the source and the drain, a gate insulating layer formed on the channel, and a source electrode and a drain electrode respectively connected with the source and the drain, a fluid line for covering the transistor to have an inner space together with the transistor and in which a sample solution including target molecules flows, a reference electrode formed on an inner wall of the fluid line, and a probe molecule layer attached on the reference electrode and reacting with the target molecules. Accordingly, the reference electrode is formed on the inner wall of the fluid line, enabling miniaturization of the bio device. Also, the probe molecules are formed on the reference electrode to measure a change in threshold voltage according to a change in electric potential between the reference electrode and the gate insulating layer, such that the sensitivity and reaction rate can be remarkably improved.03-24-2011
20100300898Analysis Tool, Analyzer, Sample Shortage Detection Method, and Sample Analysis Method - There is provided an analysis tool having a plurality of electrodes formed on a substrate. The plurality electrodes include two or more first electrodes having working electrodes and one or more second electrodes having counter electrodes. The analysis tool may also additionally have a flow channel for transferring a sample. The electrodes are preferably disposed so that the working electrodes and the counter electrodes have a symmetrical positional relationship with each other in a transferring direction of the sample in the flow channel.12-02-2010
20110155590HYBRID STRIP - A method of determining concentrations of a plurality of analytes from a single blood sample placed in a single opening. A portion of the single blood sample is absorbed by a test matrix that includes a plurality of layers and a chromogenic agent. A colored response is generated by the test matrix. The colored response is proportional to the concentration of a first analyte. A portion of the single blood sample is drawn into a capillary tube and placed in contact with an electrode and a counter-electrode. An electrical property of the single blood sample is analyzed through the electrode and counter-electrode. The electrical property is proportional to the concentration of a second analyte in the single blood sample.06-30-2011
20110155591Production Method for a Nanopatterned Epoxy Substrate - Provided is a method for preparing an epoxy substrate having a nanopattern, including: (a) forming a titanium oxide film by anodizing a titanium substrate; (b) obtaining a titanium substrate having a concave shape formed on the surface by removing the titanium oxide film from the titanium substrate on which the titanium oxide film has been formed; (c) coating an epoxy resin onto the titanium substrate on which the concave shape has been formed; and (d) obtaining an epoxy substrate having a nanopattern of convex surfaces by removing the titanium substrate. According to the presently disclosed method, an epoxy substrate having a nanopattern of convex surfaces is prepared by anodizing a titanium substrate, coating an epoxy resin onto a nanopattern formed with a concave shape on the surface of the titanium substrate, and removing the titanium substrate. This straightforward process makes it possible to efficiently prepare an epoxy substrate having a nanopattern, which is fine and on the nano scale, for the measurement of blood coagulation. Further, the epoxy substrate prepared in accordance with the present disclosure makes it possible to efficiently use an electrochemical technique to ascertain whether or not blood coagulation is present in a blood sample.06-30-2011
20090127136ELECTRODE - A diamond electrode comprises a polycrystalline mass of diamond particles bonded together and has a porous surface, or an at least partly porous surface. The porous surface of the electrode is typically created by leaching non-diamond material, such as a second phase of a metallic material, at least in part, from the bonded polycrystalline mass of diamond particles, either before or after shaping it into an electrode. Alternatively, or additionally, the porous surface of the electrode may be created by subjecting a mass of diamond particles to conditions of elevated temperature and pressure to self-bond the particles together in the absence of a second phase.05-21-2009
20090127135Method and System for Checking an Electromechanical Biosensor - A method of operating a meter for determining the concentration of an analyte in a current sample and for self-detecting electrical connection errors like short or open circuit between the electrodes of a biosensor. The method includes providing a connector with a plurality of contacts and coupling each of the plurality of contacts to one of a plurality of electrical leads on a biosensor, such that each of the plurality of connector contacts electrically contacts a corresponding one of the plurality of electrical leads. The meter obtains a first measurement between a pair of the plurality of connector contacts prior to the fluid sample being applied. The meter also obtains a second measurement between the pair of the plurality of connector contacts after the fluid sample is applied. In response to either the first or the second measurements being outside a predetermined range, a fault is indicated.05-21-2009
20100320097Method of measuring quantity of substrate - A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.12-23-2010
20110132778TEST ELEMENT CODING APPARATUSES, SYSTEMS AND METHODS - Certain exemplary embodiments include a test element operable to receive a sample and to provide an indication of an analyte of the sample to a meter. In one form test element comprises a substrate and an optically readable pattern provided on the substrate which encodes information relating to the test element.06-09-2011
20110132777Method of measuring quantity of substrate - A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.06-09-2011
20110132776Method of measuring quantity of substrate - A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.06-09-2011
20100059391METHOD FOR DETECTING BIOMOLECULES AND USE THEREOF - Biomolecule-specific probe is immobilized on an electrode surface to form a modified electrode. The modified electrode is exposed to target biomolecule. The biomolecule is captured by the probe whereby a first complex with the biomolecule is formed. Subsequently, the biomolecule is exposed to electroactive label having binding affinity to the biomolecule. The biomolecule adsorbs the electroactive label to the modified electrode to form a working electrode whereby a second complex comprising the first complex with the biomolecule and the bound electroactive label is formed. The working electrode is placed in an electrolyte medium and electrochemical measurement between the working electrode and a reference electrode is taken wherein the electrochemical measurement comprises the measurement of electrical signal resulting from a solid-state electrochemical process involving the electroactive labels. The magnitude of the electrochemical measurement corresponds to the concentration of the biomolecule present in the sample.03-11-2010
20110147234Biosensor, thin film electrode forming method, quantification apparatus, and quantification method - A biosensor according to the present invention comprises a support 06-23-2011
20090095643Amperometric Method And Apparatus For Measurement Of Soft Particles In Liquids By Analyzing The Adhesion Of These Particles To An Electrode - Method and apparatus for measurement and analysis of soft particles in liquids in the size range 1-500 μm represented by vesicles and living cells, liposomes and blood cells in particular, but also to diluted dispersions of oil droplets and other confined microparticles in liquids. The method is based on amperometric detection and analysis of single events of particle adhesion in raw samples, or after the concentration adjustment, by means of permanent record of time series of stochastic electrical signals in the real time. The detected new class of electrical signals is generated by adhesion causing the deformation, rupture and spreading of soft particles at mercury electrode in air saturated liquids. Information stored in one current pulse signal is: particle size, adhesion properties and electrode surface area occupied by the spread particle, which is characteristic for each class of particles. The current pulses, appear at irregular intervals due to the inherently stochastic nature of the I particle encounter with the electrode. The total pulse counts (N) recorded for a: fixed time interval (e.g. 100 seconds) is the measure of particle concentration; (C/particles L04-16-2009
20090166224Multi-lectin affinity chromatography and uses thereof - Methods, compositions, and kits related to the use of multi-ligand affinity chromatography are described. The methods include those related to identification of glycoprotein panels for analyzing and diagnosing disease.07-02-2009
20110139637METHOD AND APPARATUS FOR MEASURING ISOELECTRIC POINT USING FIELD EFFECT TRANSISTOR - Provided are a method and apparatus for measuring an isoelectric point using a field effect transistor. The method includes providing a field effect transistor including a substrate, source and drain electrodes disposed on the substrate and spaced apart from each other, and a channel region between the source and drain electrodes, providing a first electrolyte solution having a first concentration to the channel region of the field effect transistor and measuring a first current value of the channel region between the source and drain electrodes, providing a second electrolyte solution having a second concentration greater than the first concentration and measuring a second current value of the channel region between the source and drain electrodes, and determining as the isoelectric point of the field effect transistor or a material disposed on the field effect transistor using a difference between the first and second current values.06-16-2011
20120061259BIOSENSOR AND USAGE THEREOF - A biosensor for quantifying an analyte in a sample and usage thereof are provided. The biosensor includes an insulative substrate, a cover, a sample supply port, an electrode system including at least a working electrode, a counter electrode and a third electrode, and a reaction layer at least formed over the working electrode. The third electrode, used for estimating whether the amount of the sample is sufficient, is disposed nearer to the sample supply port than the counter electrode is. Whether the amount of the added sample is sufficient is estimated by comparing the electrical current value detected between the working electrode and the counter electrode with the electrical current value detected between the working electrode and the third electrode. This invention has a simple structure and produces accurate measurements.03-15-2012
20110315564HAND-HELD TEST METER WITH DEEP POWER CONSERVATION MODE - A hand-held test meter for use with an analytical test strip in the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a housing, a buttons electrical circuit block, at least one user operable button in operable communication with the buttons electrical circuit block; and a first-time-on (FTO) electrical circuit block. The FTO electrical circuit block is disposed within the housing and includes an activation node. In addition, the FTO electrical circuit block is configured to place the hand-held test meter into a deep power conservation mode upon the direct application of an electrical signal to the activation node by an external device (e.g., a manufacturing tester) and to terminate the deep power conservation mode and place the hand-held test meter into a normal operating mode upon receiving a predetermined user triggered signal from the at least one user operable button.12-29-2011
20120043227Method of measuring quantity of substrate - A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.02-23-2012
20090218239ELECTROCHEMICAL SENSOR - Disclosed herein is an electrochemical sensor for detecting an analyte. The sensor comprises an electrode, a redox active species that is electrochemically accessible to the electrode, and a binding moiety capable of associating with the analyte, wherein association of the binding moiety with the analyte affects the electrochemistry of the redox active species. Also disclosed herein is a method for detecting the presence of an analyte in a sample.09-03-2009
20120000795NANOCOMPOSITE BASED BIOSENSORS AND RELATED METHODS - Disclosed are nanocomposite-based biosensors. The biosensors include an electrode, a nanocomposite over the surface of the electrode, the nanocomposite comprising a population of carbon nanotubes and a population of magnetic nanoparticles dispersed in the population of carbon nanotubes, wherein the magnetic nanoparticles comprise a ferromagnetic metal or compound thereof, and one or more biomolecules over the surface of the electrode, wherein the biomolecules are capable of undergoing a redox reaction with a target molecule. Also disclosed are nanocomposites, modified electrodes, kits, and methods for using the biosensors.01-05-2012
20090242429Electrochemical Biosensor - A simple, fast, selective and highly sensitive electrochemical method assay and disposable device for detection of viruses, bacteria, proteins, DNA, and/or organic/inorganic compounds. The sensor has a multi-layered construction, with each successive layer performing a different function. The design further allows for the packing of numerous microscopic electrode transducers onto the small footprint of a biochip device, allowing for a high-density array of sensors.10-01-2009
20120006694Electrode for whole cell and other testing - A pushpen electrode is provided for electrophysiology measurements. The pushpen operation is used to impale a cell membrane in cell-attached configuration to go whole-cell without disruption of the gigaseal. The pushpen electrode has advantages over the conventional patch clamp electrode in reducing tip series resistance, increasing signal bandwidth, permitting longer-term recordings and reducing diffusion between the cytosol and the electrode solution.01-12-2012
20120061257CONCENTRIC BIPOLAR ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY TO ASSESS VASCULAR OXIDATIVE STRESS - Concentric bipolar electrode sensors and assemblies provide for and/or facilitate detection and diagnosis of the non-obstructive and pro-inflammatory atherosclerotic lesions in human arteries during catheterization using electrochemical impedance spectroscopy (EIS). Fabrication techniques for concentric bipolar electrode sensors are also described.03-15-2012
20120312699DIFFERENTIABLE ANALYTICAL TEST STRIP AND TEST METER COMBINATION - An analytical test strip and test meter combination for use in the determination of an analyte in a bodily fluid sample includes an analytical test strip and a test meter, and a method for determination thereof. The analytical test strip has an electrode, a first electrical contact pad in electrical communication with the electrode and configured to communicate an electrical response of the electrode to the test meter; and a second electrical contact pad in electrical communication with the electrode and configured to communicate an electrical response of the electrode to the test meter should the test meter be in electrical communication with the second electrical contact pad. In addition, the second electrical contact pad has electrical continuity with the first electrical contact pad and the first and second electrical contact pads are disposed in either of first and second predetermined spatial relationships to one another.12-13-2012
20090134043NON-BIOFOULING, UNIVERSAL REDOX ELECTRODE AND MEASUREMENT SYSTEM - A universal reduction-oxidation (redox) electrode allows for the temporal measurement of the redox potential of a variety of biological or environmental fluids or tissues, and assists in the diagnosis of matters related to health and disease. The electrode is made from gold which is derivatized with an electron transport promoter, such as 4-pyridinethiol and bis(4-pyridyl)disulfide. The electrode can be used to measure the redox potential of complex mediums without biofouling.05-28-2009
20100089774NON-ENZYMATIC ELECTROCHEMICAL METHOD FOR SIMULTANEOUS DETERMINATION OF TOTAL HEMOGLOBIN AND GLYCATED HEMOGLOBIN - A non-enzymatic electrochemical method of simultaneous measurement of hemoglobin (Hb) and percentage of glycated hemoglobin (% HbA1c) in a blood sample is disclosed. The method includes determining the total amount of hemoglobin in a sample by electrochemically measuring the voltammetric current due to iron (II) and iron (III) redox portions in hemoglobin and determining the percentage of glycated hemoglobin (HbA1c) by potentiometry. Also disclosed is a novel screen-printed electrode (SPE) strip modified for potentiometric measurement of HbA1c.04-15-2010
20110180427Method for Sensing a Substance to be Detected in a Sample - A single-electron transistor comprising at least a substrate, a source electrode and a drain electrode formed on top of the substrate opposing to each other, and a channel arranged between the source electrode is disclosed wherein the channel is composed of ultra fine fibers. By having such a constitution, a sensor can have excellent sensitivity.07-28-2011
20120247979Method for Enhancing Current Throughput in an Electrochemical System - An electrochemical system with reduced limiting-current behavior is disclosed. The electrochemical system is useful for fuel cells and bio-sensors. In part, the invention relates a method of reducing or eliminating limiting-current behavior in the operation electrochemical systems, in particular those with ion-selective membrane or electrochemical electrodes, by spatially reducing the convection near the membrane or the electrode. The invention further relates to electrochemical systems in which micropores, microarrays or pillar arrays are used to reduce convection in comparison to conventional systems without microarrays, micropores or pillar arrays.10-04-2012
20120247980DEVICE AND METHOD FOR MITOCHONDRIAL MEMBRANE POTENTIAL ASSESSMENT - A microfluidic sensor device includes a substrate having patterned thereon at least one Ag/AgCl electrode (working electrode) and an inner chamber overlying the at least one Ag/AgCl electrode. The device includes an ion selective permeable membrane permeable to TPP10-04-2012
20120073993ELECTROWETTING PUMPING DEVICE AND APPLICATION TO ELECTRIC ACTIVITY MEASUREMENTS - A method for pumping through an orifice of a first substrate, a first volume of liquid in contact with a first hydrophobic surface of said substrate, wherein a pressure variation between the first volume of liquid and a second volume of liquid, located in contact with said orifice and a second hydrophobic surface of said substrate, is achieved by electrowetting.03-29-2012
20120073992BIOSENSOR BASED ON CARBON NANOTUBE-ELECTRIC FIELD EFFECT TRANSISTOR AND METHOD FOR PRODUCING THE SAME - Disclosed are a biosensor, a method of producing the same, and a method of detecting a biomaterial through the biosensor. The biosensor includes a substrate, an insulating layer, source and drain electrodes formed on the insulating layer, a middle-discontinuous channel provided between the source and drain electrodes, and a detection area on which a detection target material is to be fixed, covering the middle-discontinuous channel.03-29-2012
20090020439ELECTROCHEMICAL BIOSENSOR ANALYSIS SYSTEM - An electrochemical biosensor analysis system is provided for analyzing a sample liquid, comprising a biosensor having an electrode structure made of at least two electrodes, a test field, covering the electrode structure and capable of absorbing the sample liquid, and a defined sample application surface on the top side of the test field. The system also includes an analysis instrument comprising an evaluation unit for determining the desired analysis data. The analysis instrument comprises an AC resistance measuring device for measuring an AC resistance value between two electrodes of the electrode structure by means of an area compensation measurement. The measured AC resistance value is used, in the determination of the analysis data, as a measure of the partial area of the effective electrode structure area wetted by the sample liquid.01-22-2009
20100326846METHOD FOR DETERMINING AN ANALYTE IN A BODILY FLUID SAMPLE USING AN ANALYTE TEST STRIP WITH COMBINATION ELECTRODE CONTACT AND METER IDENTIFICATION FEATURE - A method for determining an analyte in a bodily fluid sample includes inserting the analyte test strip into a test meter. The insertion is such that an electrical connector pin of the test meter travels along an electrical contact pad of the analyte test strip, and across a meter identification feature disposed on the electrical contact pad, during the insertion. Moreover, during the insertion, a signal processing module of the test meter measures an electrical characteristic via the electrical connector pin as the electrical connector pin travels along the electrical contact pad and across the meter identification feature. The method also includes identifying the analyte test strip, using the signal processing module, based on the electrical characteristic measured as the analyte test strip is inserted into the test meter and, thereafter, applying the bodily fluid sample to the analyte test strip upon notification by the test meter that the identification indicates that such applying is appropriate. The method then includes determining an analyte in the bodily fluid sample using the test meter only if the identification indicates that such determining is appropriate. The electrical contact pad of the analyte test strip employed in the method has a predetermined contact electrical characteristic value and the meter identification feature of the analyte test strip has a predetermined identification feature electrical characteristic value that is dissimilar from the predetermined contact electrical characteristic, thus providing for identification of the analyte test strip by the test meter.12-30-2010
20110120890Conductivity sensor device comprising diamond film with at least one nanopore or micorpore - Sensor device for ion channel recordings; liquid-liquid measurements and resistive pulse particle counting comprising; at least one sensor element; the element comprising a diamond thin film substrate and a pore which is a nanopore or a micropore included in the substrate. This device may be used in analysis, for instance the device may be used for single molecule detection of an apialyte (e.g. DNA), for the analysis of interactions between a sensor element and an analyte, for the detection of pore forming entities, or for the determination of ion transfer.05-26-2011
20110048972MULTI-ANALYTE TEST STRIP WITH SHARED COUNTER/REFERENCE ELECTRODE AND INLINE ELECTRODE CONFIGURATION - A multi-analyte test strip includes a first insulating layer and an electrically conductive layer disposed on the first insulating layer. The electrically conductive layer has a first working electrode with a first analyte contact pad, a shared counter/reference electrode with a counter/reference electrode contact pad, and a second working electrode with a second analyte contact pad. The multi-analyte test strip also includes a second insulating layer disposed above the first insulating layer and a patterned spacer layer positioned between the first insulating layer and the first electrically conductive layer with the patterned spacer layer defining a bodily fluid sample-receiving chamber that overlies the first working electrode, the shared counter/reference electrode and the second working electrode. The multi-analyte test strip further includes a mediator reagent layer disposed over the first working electrode, the shared counter/reference electrode and the second working electrode; a first analyte reagent layer disposed over the first working electrode and mediator reagent layer; and a second analyte reagent layer disposed over the second working electrode and mediator reagent layer. Furthermore, the first analyte electrode, shared counter/reference electrode and second analyte electrode of the multi-analyte test strip are disposed on the first insulating layer in a planar inline configuration.03-03-2011
20110210017FABRICATION OF ELECTROCHEMICAL BIOSENSORS VIA CLICK CHEMISTRY - This disclosure describes electrochemical biosensors produced using click chemistry.09-01-2011
20120325684ELECTROCHEMICAL DETECTION OF PARTICULATES IN A GASEOUS SAMPLE USING POTENTIOMETRIC MEASUREMENTS IN A GASEOUS FLAME ELECTROLYTE - The present invention provides a method for the detection of particulates in a sample, wherein the particulates are introduced into a plasma and the potential difference between a common electrode and each of a plurality of indicator electrodes is measured. The invention further provides an electrode array and an apparatus which can be used for the potentiometric detection of particulates in a sample.12-27-2012
20120325685MEASUREMENT AND USES OF OXIDATIVE STRESS - The present invention provides a method of determining the overall oxidative status of a body fluid or a tissue of a patient by measuring the oxidation-reduction potential (ORP) of the body fluid or tissue. The method has been found to be useful in the diagnosis, evaluation and monitoring of patients who have suffered a trauma (such as a head injury), patients suspected of being critically-ill or who are critically ill, patients who have an infection, and patients suspected of having a myocardial infarction (MI) or who have had an MI. The method has also been found useful in monitoring and evaluating exercise performance in patients. In addition, the method has been found useful in monitoring and evaluating stored blood products and patients who will receive such a product.12-27-2012
20130008806FLUID SENSORS AND RELATED DETECTORS AND METHODS - The present invention provides fluidic testing devices with fluidic flow channels for processing fluid samples.01-10-2013
20110139634SYSTEM AND METHOD FOR MEASURING ANALYTE CONCENTRATION WITH INTERFERANT CORRECTION - The present invention is related to an electrochemical biosensing test strip, biosensing meter, system and method for analyte measurement incorporating a hematocrit correction. The biosensor strip comprises a first and a second electrode sets respectively for detecting analyte concentration and hematocrit level. The first and second electrode sets are respectively corresponding to different reaction zones and a reaction reagent is only formed on the first electrode set corresponding reaction zone. Applying a first signal comprising a DC component and a second signal comprising an AC component that has a constant frequency respectively to the first and second electrode sets can respectively detect an uncorrected analyte concentration and hematocrit level. Therefore, the corrected analyte concentration is more accurate by incorporating the hematocrit correction.06-16-2011
20130140192Method of Producing a Lipid Bilayer and Microstructure and Measuring Arrangement - The present invention relates to a method of producing a lipid bilayer over a microcavity open on one side and to a microstructure for investigating lipid bilayers and an associated measuring arrangement. The method of producing a lipid bilayer over a microcavity open on one side comprises the following steps: filling the microcavity with an electrolyte solution; moving a fluid containing dissolved lipids in a first direction onto the microcavity; moving the fluid in a second direction away from the microcavity; monitoring the formation of the lipid bilayer over the microcavity by detecting an impedance between a counter-electrode connected to the fluid and a measuring electrode, which is arranged inside the microcavity. The microstructure has a substrate, in which at least one microcavity is formed, wherein at least one measuring electrode is arranged inside the microcavity and wherein the at least one microcavity can be connected to a fluid channel so that a laminar flow of fluid can be made to flow over the microcavity with at least two different directions of flow.06-06-2013
20090236238Electrochemical Determination of Factor XA Inhibitors - Methods and devices for determining factor Xa inhibitors, in particular heparins and fractionated or low-molecular-weight heparins, as well as direct factor Xa inhibitors in blood samples. The methods include contacting a blood sample with a detection reagent that contains at least one thrombin substrate having a peptide residue that can be cleaved by thrombin and is amidically bound via the carboxyl end to an electrogenic substance, and with a known amount of factor X reagent and an activator reagent which induces the conversion of factor X into factor Xa. Subsequently, in a second step, the amount or activity of the electrogenic substance that is cleaved from the thrombin substrate by the factor Xa-mediated thrombin activation and/or the time course thereof is determined as the measurement signal using electrochemical methods. In a third step, the amount of the factor Xa inhibitor in the sample of the blood to be analyzed or a measured quantity that correlates therewith, in particular a clotting time that correlates therewith, is determined on the basis of this measurement signal.09-24-2009
20130175185SYSTEMS AND METHODS FOR COLLECTING TEAR FILM AND MEASURING TEAR FILM OSMOLARITY - A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.07-11-2013
20100025265Potentiometric biosensor and the forming method thereof - The present invention discloses a potentiometric biosensor for urea and creatinine detection, and the forming method thereof. The disclosed biosensor comprises a substrate, at least two working electrode on the substrate, at least one reference electrode on the substrate, an internal reference electrode on the substrate, and a packaging structure which separates the adjacent electrodes. The working electrode comprises urease or creatinine iminohydrolase (CIH). The detection signal is transmitted for further processing through a wire or an exposed surface on the biosensor. The disclosed biosensor is replaceable.02-04-2010
20110220517METHOD FOR SPECIFICALLY DETECTING TEST SUBSTANCE USING PHOTOCURRENT, SENSOR UNIT USED THEREFOR, AND MEASURING DEVICE - This invention provides a method for detecting an analyte, which, in specific detection of an analyte using photocurrent that is generated by photoexcitation of a sensitizing dye, can significantly simplify the structure and a detection procedure of a sensor unit and a device using the sensor unit and can realize detection with high accuracy, and also provides a sensor unit and a device using the sensor unit. According to the method, an analyte-containing sample solution and a sensitizing dye are brought into contact with the surface of a working electrode to immobilize the sensitizing dye onto the working electrode through specific binding. Subsequently, an electrolyte is supplied in situ while allowing the sample solution to be held without being removed to bring the working electrode and a counter electrode into contact with the electrolyte. The working electrode is irradiated with light to photoexcite the sensitizing dye and thus to detect photocurrent that flows across the working electrode and the counter electrode.09-15-2011
20100307929SENSOR AND METHOD FOR MEASURING AMOUNT OF ANALYTE IN HUMAN INTERSTITIAL FLUID, FLUID CHANNEL UNIT - Disclosed is a sensor for measuring the amount of an analyte to be detected in human interstitial fluid, comprising a micro-cantilever sensing unit which includes: a first substrate; a micro-cantilever which is substantially in parallel with the first substrate and one end of which is supported onto the first substrate; a gold film formed onto at least one side of the micro-cantilever; a protein layer formed on the gold film, the protein layer being used to adsorb, at a surface thereof, the analyte to be detected in human interstitial fluid; a driving electrode provided on the first substrate; a micro-cantilever electrode which is provided on the first substrate at a position where the micro-cantilever is supported, and which is cooperated with the driving electrode so as to drive the micro-cantilever to produce resonance in a direction perpendicular to the first substrate; and a detecting electrode which is provided on the first substrate and which is cooperated with the micro-cantilever electrode so as to detect resonance frequency of the micro-cantilever. The present invention also relates to a fluid channel unit, a sensor system, and a method for measuring the amount of an analyte to be detected in human interstitial fluid.12-09-2010
20120273370TRANSDERMAL ANALYTE SENSOR ASSEMBLY AND METHODS OF USING THE SAME - A transdermal test sensor assembly adapted to determine an analyte concentration of a fluid sample is disclosed. The assembly comprises a sensor support including at least one reservoir adapted to hold a liquid. The assembly further comprises a test sensor being coupled to the sensor support. The test sensor forms at least one aperture therein. At least a portion of the at least one aperture is adjacent to the at least one reservoir. The assembly further comprises a hydrogel composition positioned on the test sensor. The hydrogel composition is linked to the at least one reservoir via the at least one aperture.11-01-2012
20110233075NANOSTRUCTURED MICROELECTRODES AND BIOSENSING DEVICES INCORPORATING THE SAME - Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.09-29-2011
20110272296Biosensor, thin film electrode forming method, quantification apparatus, and quantification method - A biosensor according to the present invention comprises a support 11-10-2011
20110272295Electrochemical Biosensor Structure and Measuring Method Using the Same - The present invention provides there is provided an electrochemical biosensor electrode structure that includes: a working electrode and a reference electrode used as electrodes for sample measurement being arranged separately from each other in lengthwise direction of a sample insertion path, the working electrode and the reference electrode each having at least one projection and at least one recess alternately arranged on a portion thereof corresponding to the sample insertion path, the projection of the working electrode being correspondingly adjacent to the recess of the reference electrode, the recess of the working electrode being correspondingly adjacent to the projection of the reference electrode; and at least two sample recognition electrodes used as electrodes for sample recognition being separated from each other and arranged adjacent and parallel to the working electrode and the reference electrode. The present invention minimizes the effect of the double layer capacitance and independently applies the sample recognition signal to accurately detect the sample insert time and velocity.11-10-2011
20110303556DEVICE AND METHOD FOR MEASURING PROTHROMBIN TIME AND HEMATOCRIT BY ANALYZING CHANGE IN REACTANCE IN A SAMPLE - Devices and methods for measuring prothrombin time (PT) and hematocrit (HCT) by analyzing the change in reactance in a sample are presented. A diagnostic device for measuring HCT and PT of a fluid includes a relative electrode-type sensor device and a blood test card assembly including one or more pairs of electrodes, wherein alternating current (AC) provided by the sensor device is used to measure and calculate HCT and PT of blood test using the reactance analysis.12-15-2011
20120061258SURFACES AND METHODS FOR BIOSENSOR CELLULAR ASSAYS - Disclosed is an apparatus for measuring ligand-induced cell activity as defined herein, the apparatus including: an optical biosensor having a contact surface including a compatibilizer zone, an optional surface modifier zone, and a live cell zone. The disclosure also provides a method of making the apparatus and methods for measuring ligand-induced live cell activity with the apparatus.03-15-2012

Patent applications in class Of biological material (e.g., urine, etc.)