Entries |
Document | Title | Date |
20080296160 | CAPILLARY ELECTROPHORESIS DEVICE - Provided is a capillary electrophoresis device including a holder preventing a septum from coming off when a capillary is pulled out, and also allowing containers to be taken out in any order. In the capillary electrophoresis device for separating and analyzing a sample such as a DNA and a protein by electrophoresis, the holder includes: a septum having a capillary hole through which a capillary penetrates; a container for storing a solution; and a container-accommodation unit for accommodating the container. A hole formed in the septum engages with an engagement portion formed on the container, and thereby the septum is held to cover the container. | 12-04-2008 |
20080302665 | CAPILLARY ARRAY APPARATUS, METHOD OF MANUFACTURING THE SAME, AND ELECTROPHORESIS ANALYSIS METHOD - An electrophoresis analysis method and apparatus capable of maintaining high reliability upon a repeated use of the same gel. A heat transfer medium selected from the group consisting of solids, liquids and gels is filled in substantially all of the gaps between the electrode and each capillary. A hollow electrode into which a capillary is inserted has a plurality of retaining shapes such that the capillary can be fixed at the center of the electrode. The heat from the capillary can be efficiently dissipated via the electrode, and also the temperature increase in the capillary can be prevented. Further, temperature increases due to the heating of the capillaries during operation can be controlled and thereby thermal deterioration of the gel can be prevented. | 12-11-2008 |
20090071832 | MICROFLUIDIC DEVICE WITH VERTICAL INJECTION APERTURE - A microfluidic device with a vertical injection aperture is provided. The microfluidic device comprises a separation channel, an injection aperture disposed adjacent to and in fluid communication with the separation channel. The microfluidic device further comprises a semi-permeable filter disposed adjacent to the injection aperture, wherein the filter is configured to preconcentrate a sample in the injection aperture to form a preconcentrated sample plug during an injection operation, and wherein the sample plug flows downwardly from the injection aperture to the separation channel during an electrophoresis operation. | 03-19-2009 |
20090071833 | Method and device for manipulating liquids in microfluidic systems - The present invention relates to microfluidic systems having components with specially designed and fabricated areas of enhanced and/or reduced capillarity (flow guides). The methods and devices of the present invention permit the bubble-less dispensing and mixing of small volumes of different liquids for subsequent incubation and/or detection of products of various biological reactions. Thus present invention is well-suited to applications such as polymerase chain reaction and capillary electrophoresis. | 03-19-2009 |
20090107844 | GLASS ELECTROPHORESIS MICROCHIP AND METHOD OF MANUFACTURING THE SAME BY MEMS FABRICATION - Embodiments of the present invention may provide a microchip applicable to an electrophoresis employing UV detection and a method of manufacturing the same. The microchip of the present invention has a glass channel plate, which is formed on an upper surface thereof with a loading channel and a separation channel and is provided on the upper surface thereof with an optical slit layer made of silicon except the channel region, and a glass reservoir plate, which is formed with sample solution reservoirs and buffer solution reservoirs. The loading channel and the separation channel are formed on the channel plate by deep reactive ion etching. The sample solution reservoirs and the buffer solution reservoirs are formed in the reservoir plate by sand blasting. The channel plate and the reservoir plate are combined by anodic bonding the optical slit layer and the reservoir plate. Electrodes for sample and electrodes for buffer are deposited by sputtering Pt with a shadow mask after anodic bonding. | 04-30-2009 |
20090166206 | ELECTROPHORESIS CHIP - An electrophoresis chip is provided with a channel that is filled with a solution in which a sample is dissolved, the electrophoresis chip being configured to carry out electrophoresis by applying voltage along the channel in a state in which the channel is hermetically sealed to separate the sample in the channel, and after this electrophoresis is performed, to carry out mass spectrometry by scanning a laser along the channel in a state in which the channel is open to an environment in which gas is present. A pattern is formed on the bottom surface of the channel to hold the solution as droplets. This pattern is made into a pattern in which hydrophilic areas are surrounded by hydrophobic areas and side-walls of the channel. | 07-02-2009 |
20090200168 | ELECTRICAL CONTACT ELEMENT FOR MICROFLUIDIC CHIP - A contacting device, comprising a contacting element ( | 08-13-2009 |
20090218226 | Separation device of molecules and production method thereof - Separation device of molecules and production method thereof. A molecule is separated from a liquid sample containing said molecule and at least one additional molecule having a larger hydrodynamic diameter than the hydrodynamic diameter of the molecule to be separated, by means of a separation device comprising a substrate, at least one circulation channel arranged in said substrate, and at least one nanotube associated with said molecule to be separated and formed on a free surface of the substrate. Separation is achieved by means of the internal channel of a nanotube, such as a carbon nanotube, presenting an effective diameter chosen in predetermined and controlled manner. The effective diameter of the internal channel is chosen such as to be larger than the hydrodynamic diameter of the molecule to be separated and smaller than the hydrodynamic diameter of the additional molecules of larger hydrodynamic diameters. | 09-03-2009 |
20090229983 | Ruggedized apparatus for analysis of nucleic acid and proteins - The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location. | 09-17-2009 |
20090250348 | Droplet microfluidic transporting module - A droplet microfluidic transporting module adapted for transporting a droplet is disclosed to include one or a number of connectors and one or a number of microfluidic transporting platform. Each connector defines a passage extending in one or multiple predetermined directions, and a first driving electrode extending along one side of the passage for the contact of the droplet to be transported. The microfluidic transporting platform is detachably electrically connected with the connector, defining a channel in communication with the passage of the connector and having a second driving electrode extending along one side of the channel for the contact of the droplet to be transported. | 10-08-2009 |
20090266713 | CHANNELLESS FLUIDIC SAMPLE TRANSPORT MEDIUM - A fluidic device ( | 10-29-2009 |
20090283408 | Universal Interface for a Micro-fluidic Chip - An integrated capillary electrophoresis system comprising a universal interface is disclosed. The universal interface includes one or more of the following structural elements: a chip assembly that receives a capillary electrophoresis CE chip; a fluidic interface for coupling fluids between the chip assembly and external sources or destinations; a first electrical interface for coupling power from an external source to the chip assembly; a second electrical interface for coupling electrical signals from the chip assembly to external analysis electronics; an optical interface for coupling optical signals between the chip assembly and external sources or destinations; and a docking station for uniting and spatially locating the various other structural elements. | 11-19-2009 |
20090301885 | Electrophoresis extraction device - An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest. | 12-10-2009 |
20090321263 | CLINICAL ANALYSIS APPARATUS - To enable reuse of expensive microchips in a clinical analysis apparatus, while constantly and efficiently obtaining accurate analysis results. A clinical apparatus employs microchips to analyze substances, which are contained in samples and are targets of measurement. The clinical analysis apparatus is equipped with: a stocking section; a dispensing mechanism, for dispensing reagents stocked in the stocking section and samples to the microchips; and a measuring section, for measuring the measurement target substance within the samples. The measuring section includes: a dispensing station, at which the microchips are provided; a detecting station, for detecting the measurement target substance; and a cleansing station, at which microchips are cleansed following detection of the measurement target substance. The dispensing station, the detecting station, and the cleansing station are provided at a predetermined pitch from upstream to downstream positions. The microchips are continuously rotated through the stations to perform measurement repeatedly. | 12-31-2009 |
20100018864 | LAB-ON-A-CHIP WITH COPLANAR MICROFLUIDIC NETWORK AND COPLANAR ELECTROSPRAY NOZZLE - A lab-on-a-chip comprising a support plate, at least one fluidic network formed in a fluidic plate bonded onto the support plate, and a cover plate bonded onto the fluidic plate and covering the fluidic network. The fluidic network, at a first end, is connected to an inlet orifice allowing entry of a liquid to be sprayed and, at a second end, to a first end of an outlet channel for the liquid to be sprayed, formed in the fluidic plate. The fluidic plate is extended by a pointed electrospray nozzle at which the second end of the outlet channel forms the electrospray outlet of the lab-on-a-chip. The cover plate has a pointed extension forming a roof for that part of the channel located in the electrospray nozzle. | 01-28-2010 |
20100025248 | ELECTROPHOERSIS CHIP - An electrophoresis chip capable of suppressing the drift phenomenon is provided. The electrophoresis chip includes a channel which separates a sample by isoelectric focusing electrophoresis and a plurality of columnar structures disposed all over the channel. The columnar structures are disposed such that the flow of a sample solution, which moves in the longitudinal direction of the channel, is disturbed. | 02-04-2010 |
20100032296 | SYSTEMS AND METHODS FOR QUANTITATIVE ANALYTE TRANSFER - Systems and methods for enhancing quantitative transfer of analytes to an adsorptive substrate are provided. A preferred embodiment provides an improved transfer system and method that reduces “blow through” of low molecular weight analytes and increases the adsorption of low molecular weight, for example proteins of about 30 kDa or less compared to conventional transfer techniques. It has been discovered that using a secondary porous backing membrane in conjunction with an adsorptive membrane such as nitrocellulose or polvinylidene fluoride increases the efficiency of analyte interaction with the adsorption membrane compared to transfers techniques using the adsorption membrane without the secondary backing membrane. This improvement of quantitative analyte transfer efficiency facilitates a wider range of detection processes, such as direct analysis by MALDI mass spectrometry than in earlier applications of the process without the secondary backing membrane. | 02-11-2010 |
20100032297 | Electrophoresis Chip and Electrophoresis Apparatus - An electrophoresis chip that enables an apparatus to be small, analysis time to be short and glycosylated hemoglobin to be analyzed highly accurately is provided. The electrophoresis chip includes an upper substrate | 02-11-2010 |
20100044231 | LATERAL OPENING FOR FLUID INTRODUCTION - A microfluidic chip ( | 02-25-2010 |
20100108519 | Polymeric Nanopillars and Nanotubes, Their Manufacture and Uses - A method is disclosed for fabricating free-standing polymeric nanopillars or nanotubes with remarkably high aspect ratios. The nanopillars and nanotubes may be used, for example, in integrated microfluidic systems for rapid, automated, high-capacity analysis or separation of complex protein mixtures or their enzyme digest products. One embodiment, preferably fabricated entirely from polymer substrates, comprises a cell lysis unit; a solid-phase extraction unit with free-standing, polymeric nanostructures; a multi-dimensional electrophoretic separation unit with high peak capacity; a solid-phase nanoreactor for the proteolytic digestion of isolated proteins; and a chromatographic unit for the separation of peptide fragments from the digestion of proteins. The nanopillars and nanotubes may also be used to increase surface area for reaction with a solid phase, for example, with immobilized enzymes or other catalysts within a microchannel, or as a solid support for capillary electrochromatography-based separations of proteins or peptides. | 05-06-2010 |
20100108520 | ELECTROPHORESIS CHIP AND ELECTROPHORESIS UNIT HAVING THE SAME - In order to provide a high-performance electrophoresis chip and an electrophoresis unit having the same that can restrain the diffusion of sample at an intersection between the electrophoresis groove and the sample introduction groove and prevent decrease in contrast and decrease in resolution, an electrophoresis chip is provided with a sample introduction groove, an electrophoresis groove, and a through hole. The sample introduction groove, the electrophoresis groove, and the through hole are formed on different substrates. In the electrophoresis chip, by combining the substrates, the sample introduction groove and the electrophoresis groove are located in different planes. | 05-06-2010 |
20100181199 | ANALYSIS APPARATUS FOR CAPILLARY ELECTROPHORESIS - A capillary electrophoresis analysis apparatus is provided for analyzing samples by a capillary electrophoresis method that allows for rapid and highly accurate separation and detection. | 07-22-2010 |
20100270160 | Portable Low Power Charged Particle Analysis Device - The present invention is a portable low power system for charged particle analysis using electro kinetic flow in a Microfluidic channel, which may be interfaced with a computing device. The system consists of three parts: A required hardware device, an optional software client application and an optional software server application. The hardware based device may control the flow of ions through a Microfluidic channel based on specific analysis protocols and analyzes the sample to identify the ions; the optional software based client and server applications may support the process by performing at least one of following functions: hosting the analysis, hosting newly detected and old analyte signature data, and analyzing the detected signatures. | 10-28-2010 |
20100288641 | Electrophoresis Capillaries Having Reduced Amounts of -OH - A silica substrate for subjecting a sample to electrophoresis has an —OH concentration of less than 100 parts per million. | 11-18-2010 |
20110000791 | CAPILLARY DRIVEN ASSAY DEVICE AND ITS MANUFACTURE - A method for the manufacture of a capillary driven assay device, includes the steps of: a) providing a capillary substrate, b) modifying the hydrophilicity of the surface of the substrate, c) mixing a matrix and a capturing molecule in a solution to obtain a solution comprising capturing molecules covalently bound to the matrix, and d) depositing the solution in a distinct area in the at least one retaining zone. A capillary driven assay device is obtainable by the method permitting the substrate to be modified with one surface chemistry and capturing molecules to be deposited in an optimal matrix on desired areas. Less matrix material is consumed, permitting several different matrix materials to be used on one chip. | 01-06-2011 |
20110100823 | Droplet-Based Nucleic Acid Amplification Apparatus and System - The present invention relates to a droplet-based nucleic acid amplification apparatus and system. According to one embodiment, a droplet microactuator is provided made using a first substrate including a fluorescing material and including a detection region for detecting a fluorescence signal from a droplet, which detection region is coated with a light absorbing, low fluorescence or non-fluorescing material. | 05-05-2011 |
20110108424 | DEVICE FOR SEPARATING BIOMOLECULES FROM A FLUID - The device for separating biomolecules from a fluid comprises a microfluidic component provided with at least one microchannel having at least one of the walls supporting a plurality of nanotubes or nanowires. The component comprises at least one electrode electrically connected to at least a part of the nanotubes or nanowires and the device comprises means for applying a voltage between the electrode and the fluid. The nanotubes or nanowires are divided into several active areas in which the nanotubes or nanowires have a different density. | 05-12-2011 |
20110127165 | SIEVING MEDIA FROM PLANAR ARRAYS OF NANOSCALE GROOVES, METHOD OF MAKING AND METHOD OF USING THE SAME - Disclosed herein are an apparatus and a method for separating molecules on the basis of size and or structure, and to a method of making the apparatus. Generally, the separation method includes passing a fluid comprising particles having different effective molecular diameters through a plurality of open, nanoscale channels disposed in surfaces of substrates. The method also includes obtaining a plurality of fractions of the passed fluid such that each of the fractions includes a major portion containing particles having similar size and shape and substantially free of particles having larger size and shape. The apparatus includes first and second substrates each of which has a surface containing a plurality of open, nanoscale channels disposed therein. The surfaces are bonded together such that each of the channels of the first substrate is in fluid communication with at least two of the channels of the second substrate and is misaligned relative to the channels of the second substrate. Interferometric lithography and anodic bonding or flip-chip bonding techniques can be used to make the apparatus. | 06-02-2011 |
20110174625 | COMPOSITIONS, DEVICES, SYSTEMS, AND METHODS FOR USING A NANOPORE - The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. | 07-21-2011 |
20110220507 | MICROCHANNEL-TYPE FLUID MIXING APPARATUS USING AC ELECTROOSMOTIC FLOWS (AC-EOF) AND INCLINED-ELECTRODE PATTERNS - The present invention provides a microchannel-type fluid mixing apparatus using AC electroosmotic flows (AC-EOF) for inducing the mixing of fluid materials flowing in a microchannel and inclined-electrode patterns. The fluid mixing apparatus according to the present invention enables the electrical connection between the respective electrodes arranged inclinedly along a lengthwise direction of a microchannel on an inner bottom wall surface of the microchannel and the power supply unit for supplying AC power is controlled by the controller so that AC power form the power supply unit is applied to the electrodes in two patterns alternately performed over time. Thus, the fluid materials vortically flow in a vertical direction over the respective electrodes while changing their rotational direction over time, leading to a smooth mixing of the fluid materials. Particularly, the present invention enhances the mixing efficiency of fluid materials while employing a simplified electrode arrangement structure. | 09-15-2011 |
20110240473 | Dielectrophoretic Cell Chromatography Device with Spiral Microfluidic Channels and Concentric Electrodes, Fabricated with MEMS Technology - This dielectrophoretic micro cell chromatography device with concentric electrodes and spiral microfluidic channels, produced according to MEMS technology subject to this invention; is composed of 4 groups of effect electrodes, inlet electrodes, spiral zone and central span, having exterior upper electrode ( | 10-06-2011 |
20120012462 | Electrophoresis Chip and Electrophoresis Apparatus - An electrophoresis chip that enables an apparatus to be small, analysis time to be short and glycosylated hemoglobin to be analyzed highly accurately is provided. The electrophoresis chip includes an upper substrate | 01-19-2012 |
20120024706 | APPARATUS FOR THE MEASUREMENT OF A CONCENTRATION OF A CHARGED SPECIES IN A SAMPLE - An apparatus ( | 02-02-2012 |
20120160690 | Capillary Column Cartridge - Described is a capillary column cartridge. The cartridge can be used to perform separations according to various techniques such as capillary gas chromatography, capillary electrophoresis and capillary liquid chromatography. The cartridge includes a capillary column secured in a cartridge body. The capillary column includes an inlet port and an outlet port that, in some embodiments, are disposed on a planar surface of the body. When the body is engaged to a separation system module, the inlet port is aligned to receive a sample to be separated and the outlet port is aligned to provide the separated sample to the separation system module. The path of the capillary through the body has a non-planar path shape such as a coil shape. Consequently, longer column lengths can be accommodated, leading to an improvement in separation resolution. The body can include a material having a high thermal conductivity to achieve improved thermal performance. | 06-28-2012 |
20120168311 | Systems And Methods For Coupling Molecule Separation Devices To Analytical Instruments - Described is a capillary that interfaces with an analysis system. The capillary comprises a non-conductive tubing and a conductive region proximate to an output end of the non-conductive tubing. The conductive region comprises a plurality of porous regions and non-porous regions positioned about a circumference of the non-conductive tubing. The porous regions separated from each other by the non-porous regions. Advantageously, the arrangement of porous regions provides mechanical stability about the conductive region. | 07-05-2012 |
20120193234 | CAPILLARY ELECTROPHORESIS CHIPS - A seamless microchannel with aligned microelectrodes structure can be prepared to include a polymeric body defining a surface of a seamless microchannel. The microchannel is seamless in that it is formed by a single body of material having a conduit that is open at one surface and extends to another opening aligned with microelectrodes in another surface of the body. The rest of the microchannel is closed and defined by the single body of material. The seamless microchannel structure can be used in methods that include biosensors, coupling waveguides, capillary electrophoresis chips, microreactors, polymerase chain reaction-chips, and solving mathematical problems. | 08-02-2012 |
20120193235 | DNA MOTION CONTROL BASED ON NANOPORE WITH ORGANIC COATING FORMING TRANSIENT BONDING TO DNA - A nanodevice includes a reservoir filled with a conductive fluid and a membrane separating the reservoir. The membrane includes an insulating layer. A nanopore is formed through the membrane, and an organic coating is provided on the insulating layer to form a transient bond to a DNA molecule in the nanopore. The transient bond is stronger than thermal motion, such that the transient bond can hold the DNA molecule against the thermal motion. When a voltage is applied across the membrane, the voltage will break the transient bond to move the DNA molecule through the nanopore in a controllable state. | 08-02-2012 |
20120261263 | THREE-DIMENSIONAL NANOCHANNEL DEVICE AND METHOD OF MANUFACTURING THE SAME - A three-dimensional nanochannel device and a method of manufacturing the same are provided. In the device, a first substrate, a second substrate, and a channel layer sandwiched by the first and the second substrates are included. At least one channel is constituted by the first and the second substrates and the channel layer and includes a fluid inlet, a fluid outlet, and at least one condensed channel between the fluid inlet and the fluid outlet. The condensed channel at least has a first size and a second size on an X-Y plane and has a third size and a fourth size on an X-Z plane. A difference between the first size and the second size is about at least two orders in scale, and a difference between the third size and the fourth size is about at least two orders in scale. | 10-18-2012 |
20120267247 | Ruggedized Apparatus for Analysis of Nucleic Acid and Proteins - The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location. | 10-25-2012 |
20120292189 | CAPILLARY ELECTROPHORESIS APPARATUS - The invention provides a capillary electrophoresis apparatus which can improve the operability and measuring speed. According to the invention, a sensor for identifying the type of sample containers is fixed at the position away from a capillary anode electrode. The sensor is made to be closer to the sample containers by moving a moving stage so that the sample containers disposed on the moving stage can be identified by the sensor. A fixing apparatus for fixing at least a pair of sample containers is provided on the moving stage. | 11-22-2012 |
20120298510 | NANOPORE BASED DEVICE FOR CUTTING LONG DNA MOLECULES INTO FRAGMENTS - Apparatus, system, and method are provided for cutting a linear charged polymer inside a nanopore. A first voltage is applied to create an electric field in a first direction. A second voltage is applied to create an electric field in a second direction, and the first direction is opposite to the second direction. When the electric field in the first direction and the electric field in the second direction are applied to a linear charged polymer inside a nanopore, the linear charged polymer is cut at a location with predetermined accuracy. | 11-29-2012 |
20120305399 | ELECTROKINETIC PUMPING OF NONPOLAR SOLVENTS USING IONIC FLUID - Techniques are generally described that include electrokinetic pumping an emulsion comprising an ionic fluid and a nonpolar fluid to promote flow of the ionic fluid by electro-osmotic flow and drag the nonpolar fluid by viscous drag forces. In some examples, the electrokinetic pump may be utilized to deliver one or more reagents within a fluidic reactor system, such as a micro-scale reactor system. In some additional examples, a reagent may be dissolved in the nonpolar fluid of a first emulsion and pumped through the electrokinetic pump to a mixing channel to allow the reagent of the first emulsion to react with a reagent of second emulsion to form a reactive product. | 12-06-2012 |
20120325664 | NANOSENSOR AND METHOD OF MANUFACTURING THE SAME - A nanosensor comprising a substrate having a hole; a first insulating layer disposed on the substrate and having a first nanopore at a location corresponding to the hole in the substrate; first and second electrodes disposed on the first insulating layer, wherein the first and second electrodes are spaced apart from each other with the first nanopore positioned therebetween; a first electrode pad disposed on at least a portion of the first electrode; a second electrode pad disposed on at least a portion of the second electrode; and a protective layer disposed on at least a portion of the first and second electrode pads; as well as a method for manufacturing same. | 12-27-2012 |
20120325665 | MICROFLUIDIC DEVICES WITH FLEXIBLE OPTICALLY TRANSPARENT ELECTRODES - Microfluidic devices in which electrokinetic mechanisms move droplets of a liquid or particles in a liquid are described. The devices include at least one electrode that is optically transparent and/or flexible. | 12-27-2012 |
20130037410 | Nanopore Sensor Comprising A Sub-Nanometer-Thick Layer - A nanopore sensor comprises second electrophoresis electrode or micropump, second fluidic reservoir, second micro-nanometer separation channel, substrate, sub-nanometer-thick functional layer, first micro-nanometer separation channel, first electrophoresis electrode or micropump, and electrophoresis electrode or micropump that are sequentially assembled. An opening and a nanopore are provided through the substrate and the sub-nanometer-thick functional layer, respectively. A first electrode for measuring ionic current is provided in the first micro-nanometer separation channel, and a second electrode for measuring ionic current is provide in the second micro-nanometer separation channel. The present invention provides a simple method to prepare a sub-nanometer functional layer having a nanopore extending through the sub-nanometer-thick functional layer. The pore size is comparable to the spacing between two adjacent bases in a DNA strand required for single-base resolution sequencing. The shape of nanopore overcomes nucleotide conformation effect on the identification as bases translocate through the nanopore. | 02-14-2013 |
20130161192 | APPARATUS AND METHOD FOR LINEARLY TRANSLOCATING NUCLEIC ACID MOLECULE THROUGH AN APERTURE - An apparatus and method for linearly translocating nucleic acid molecules through an aperture at a reduced rate. | 06-27-2013 |
20130213812 | THREE-DIMENSIONAL MICROFLUIDIC MICRO-DROPLET ARRAYS FOR ELECTRONIC INTEGRATED CIRCUIT AND COMPONENT COOLING, ENERGY-HARVESTING, CHEMICAL AND BIOCHEMICAL MICROREACTORS, MINIATURE BIOREACTORS, AND OTHER APPLICATIONS - A microfluidic transport system for transporting microdroplets in three spatial dimensions. In an example arrangement, a first planar arrangement for transporting microdroplets in two spatial dimensions responsive to electric fields created by electrical operation of electrodes is fluidically connected by one or more conduits to other planar arrangement for transporting microdroplets in two spatial dimensions responsive to electric fields created by electrical operation of electrodes. Microdroplets can be transported through the one or more conduits so as to be moved among the first and second planar arrangements. | 08-22-2013 |
20130248368 | SENSING APPARATUS USING RADIO FREQUENCY AND MANUFACTURING METHOD THEREOF - A sensing apparatus using a radio frequency and a manufacturing method thereof is provided. A sensing apparatus using a radio frequency includes a protecting layer configured to protect a substrate from migration of electrons occurring as the radio frequency is applied to a first electrode and a second electrode, a channel forming layer configured to form a channel based on a field between the first electrode and the second electrode, the channel forming layer using a polarized carbon-based nano material to form the channel, and a sensing layer configured to sense glucose using a medium material that is attached on the carbon-based nano material. | 09-26-2013 |
20130256137 | APPARATUS AND METHOD FOR MOLECULAR SEPARATION, PURIFICATION, AND SENSING - Described are devices and methods for forming one or more nanomembranes including electroactive nanomembranes within a nanowell or nanotube, or combinations thereof, in a support material. Nanopores/nanochannels can be formed by the electroactive nanomembrane within corresponding nanowells. The electroactive nanomembrane is capable of controllably altering a dimension, a composition, and/or a variety of properties in response to electrical stimuli. Various embodiments also include devices/systems and methods for using the nanomembrane-containing devices for molecular separation, purification, sensing, etc. | 10-03-2013 |
20130256138 | MICROFLUIDIC SYSTEM - A method for forming a microfluidic channel with improved flow characteristics for one or more analytes is disclosed. A microfluidic channel having modified surfaces is formed in a glass layer or glass substrate. The glass surfaces of the microfluidic channel are modified by the addition of a layer of borophosphosilicate glass. The addition of the borophosphosilicate glass results in an improved flow velocity profile of the analyte. As a result, control over the position and movement of analytes within the solution is improved. | 10-03-2013 |
20130292250 | CAPILLARY ELECTROPHORESIS SYSTEM - The invention is an improved multiplex capillary electrophoresis instrument or module with at least four and preferably six user-accessible vertically stacked drawers. An x-z stage moves samples from the user accessible drawers to the capillary array for analysis. A computer program allows users to add capillary electrophoresis jobs to a queue corresponding to the analysis of rows or plates of samples without stopping or interrupting runs in progress. | 11-07-2013 |
20130299352 | THREAD-BASED MICROFLUIDIC GUIDING SYSTEM - A thread-based microfluidic guiding system is provided and includes a substrate, two fiber threads arranged on the substrate in a cross manner. The two fiber threads are used as physical guiding pathways to guide a sample fluid and a buffer fluid, respectively. The two fiber threads have capillary action, so that the sample fluid, the buffer fluid or a mixture fluid thereof can flow along fiber surfaces of the two fiber threads, which can be pre-treated by plasma. The thread-based microfluidic guiding system of the present invention is different from recessed microfluidic channel structures, and can simplify system structure, lower manufacture cost, accelerate detection operation and enhance detection sensitivity. | 11-14-2013 |
20130341191 | PERFORMANCE OF AN ANALYSER FOR BIOLOGICAL SAMPLES - An apparatus ( | 12-26-2013 |
20130341192 | COMPENSATED PATCH-CLAMP AMPLIFIER FOR NANOPORE POLYNUCLEOTIDE SEQUENCING AND OTHER APPLICATIONS - A compensated patch-clamp system for polynucleotide sequencing and other applications. | 12-26-2013 |
20140014517 | Droplet Actuator - Droplet actuator for conducting droplet operations, such as droplet transport and droplet dispensing, is provided. In one embodiment, the droplet actuator may include an electrode that is rotationally but not reflectively symmetrical. | 01-16-2014 |
20140027287 | INCREASED MOLECULE CAPTURE RATE INTO A NANOPORE - A mechanism for capturing molecules is provided. A nanopore through a membrane separates a first chamber from a second chamber, and the nanopore, the first chamber, and the second chamber are filled with ionic buffer. A narrowed neck is at a middle area of the first chamber, and the narrowed neck is aligned to an entrance of the nanopore. The narrowed neck has a high intensity electric field compared to other areas of the first chamber having low intensity electric fields. The narrowed neck having the high intensity electric field concentrates the molecules at the middle area aligned to the entrance of the nanopore. Voltage applied between the first chamber and the second chamber drives the molecules, concentrated at the entrance of the nanopore, through the nanopore. | 01-30-2014 |
20140083858 | HETEROGENEOUS INTEGRATION OF MICROFLUIDIC DEVICES IN PACKAGE STRUCTURES - Methods of forming a microelectronic packaging structure and associated structures formed thereby are described. Those methods may include attaching a microfluidic die to a package structure, wherein the microfluidic die comprises a plurality of asymmetric electrodes that may be coupled with signal pads disposed within the package structure. | 03-27-2014 |
20140083859 | BIOFUNCTIONAL NANOFIBERS FOR ANALYTE SEPARATION IN MICROCHANNELS - A method is provided for producing, in a substrate, an enclosed channel or enclosed cavity comprising at least one functional nanofiber, the method comprising the steps of providing a first substrate and a second substrate; forming a channel or cavity on the first substrate or the second substrate; electrospinning at least one functional nanofiber on the first substrate; assembling the first and second substrates, wherein the first substrate is placed over the second substrate, or the second substrate is placed over the first substrate; and bonding the first substrate and the second substrate to form the substrate, thereby forming an enclosed channel or enclosed cavity comprising the at least one functional nanofiber in the substrate. An enclosed channel or cavity comprising at least one functional electrospun nanofiber is also provided. A microfluidic device is also provided comprising an enclosed channel or cavity comprising at least one functional electrospun nanofiber. | 03-27-2014 |
20140190832 | Microfluidics Systems with Waste Hollow - Digital microfluidics system manipulates samples in liquid droplets within a gap of at least one disposable cartridge. It is also provides additional space for collecting and/or storing waste fluids in this digital microfluidics system. It includes at least one waste hollow which is fluidly connected with a gap of a disposable cartridge that includes a bottom layer with a first hydrophobic surface and a top layer with a second hydrophobic surface. The waste hollow is located next to at least one individual waste electrode that is positioned next to at least one individual electrode of an electrode array. Each individual waste electrode is operatively connected to a central control unit and covers in each case a waste electrode area. | 07-10-2014 |
20140197031 | DISPOSABLE CAPILLARY ELECTROPHORESIS DETECTING DEVICE - A disposable capillary electrophoresis detecting device includes a fixing device, a capillary electrophoresis microchip, and an electrochemical sensor microchip. The fixing device includes two chip-fixing bases having a first chip-holding cavity horizontally arranged and a second chip-holding cavity vertically arranged. The second chip-holding cavity is substantially perpendicular to the first chip-holding cavity and faces an end portion thereof. The capillary electrophoresis microchip is horizontally placed in the first chip-holding cavity. The electrochemical sensor microchip is vertically placed in the second chip-holding cavity. In the electrochemical sensor microchip, a patterned insulation layer is located on a detecting electrode, exposes a sensor area of the detecting electrode, and is extended to two sides of the sensor area. The outlet of the separation capillary of the capillary electrophoresis microchip is aligned to the sensor area, and the distance between the outlet and the sensor area is the thickness of the patterned insulation layer. | 07-17-2014 |
20140202866 | NANOSENSOR AND METHOD OF MANUFACTURING SAME - A nanosensor may include a substrate that has a hole formed therein, a first insulating layer that is disposed on the substrate and has a nanopore formed therein, first and second electrodes that are disposed on the first insulating layer and are spaced apart from each other, first and second electrode pads that are disposed on the first and second electrodes, respectively, and a protective layer disposed on the first and second electrode pads. A method of manufacturing a nanosensor may include forming a first insulating layer, graphene, and a metal layer on a substrate, patterning the metal layer and the graphene, forming a protective layer on a portion of the graphene and the metal layer, exposing a portion of the graphene by removing a portion of the protective layer, forming a hole in the substrate, and forming a nanopore in the first insulating layer and the graphene to be connected to the hole. | 07-24-2014 |
20140231259 | Filler Fluids for Droplet Operations - The present invention relates to filler fluids for droplet operations. According to one embodiment of this aspect, a droplet microactuator including an opaque filler fluid and a transparent droplet thereon is provided. The droplet microactuator may further include a first substrate comprising electrodes configured to effect electrowetting mediated droplet operations on a surface of the first substrate; a second substrate spaced apart from the surface of the first substrate by a distance sufficient to define an interior volume between the first substrate and second substrate; and wherein the droplet and the filler fluid are in the interior volume, and wherein the droplet is surrounded by the filler fluid and arranged with respect to the electrodes in a manner which permits electrowetting mediated droplet operations to be effected on the droplet using the electrodes. | 08-21-2014 |
20140246321 | PARTICLE SEPARATION DEVICE AND METHOD - Micropillars are arranged a first row up to an nth row, the micropillars in one row are disposed at the same interval “a” from each other, and each of the rows is disposed in a position shifted by a distance “b” with respect to an immediately preceding upstream row, in a row direction. A liquid that contains particles flows through between the micropillars. A voltage is applied from a power supply to electrodes, thereby generating an electric field in a flow channel. The micropillars are electrical insulating structures, so in regions of narrow intervals between the micropillars, electrical lines of force are dense and strength of the electric field is high, and in regions of wide intervals between the micropillars, electrical lines of force are sparse and the strength of the electric field is low. | 09-04-2014 |
20140251812 | APPARATUS FOR THE MEASUREMENT OF A CONCENTRATION OF A CHARGED SPECIES IN A SAMPLE - An apparatus ( | 09-11-2014 |
20140284213 | Multichannel Preparative Electrophoresis System - The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system. | 09-25-2014 |
20140311910 | MICROCHIP AND METHOD OF MANUFACTURING MICROCHIP - Provided is a microchip including: an inlet part to which a liquid is injected; a plurality of analysis areas to which the liquid is supplied from the inlet part; and a flow channel which is formed to supply the liquid to the plurality of analysis areas at the same time. | 10-23-2014 |
20140318970 | NANOPORE DEVICE FOR DRUG-LIKE MOLECULE SCREENING OR LEAD OPTIMIZATION TO A TARGETED PROTEIN - A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged molecule to pass but to block a protein molecule attached to a ligand connecting to the charged molecule, the opening being filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged molecule through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged molecules passing into the opening. The current changes are employed to trigger a bias field increase to cause separation between the ligand and the protein to infer an interaction strength. | 10-30-2014 |
20150021187 | NANOFLUIDIC CHANNELS WITH GRADUAL DEPTH CHANGE FOR REDUCING ENTROPIC BARRIER OF BIOPOLYMERS - A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer. | 01-22-2015 |
20150021188 | MICROFLUIDIC DEVICES AND METHODS OF MANUFACTURE THEREOF - A microfluidic device comprising: a substrate having a microfluidic channel, an electrically conductive feature comprising an electrically conductive layer arranged on a primer layer and positioned with reference to the microfluidic channel, wherein the primer layer comprises: (i) an organic polymer selected from the group consisting of: (a) a homopolymer or copolymer including a vinyl lactam repeating unit, (b) a cellulose ether; (c) polyvinyl alcohol; and (d) unmodified or modified gelatin; and (ii) a porous particulate material, the organic polymer being dispersed in the porous particulate material, is provided. Methods for manufacturing the microfluidic devices and their use in a number of applications are also provided. | 01-22-2015 |
20150041324 | MICROFLUIDIC SENSOR PACKAGE STRUCTURE AND METHOD - In one embodiment, a microfluidic sensor device includes microfluidic sensor mounted on and electrically connected a micro lead frame substrate. The microfluidic sensor is molded to form a package body. The package body includes a molded panel portion and, in some embodiments, a mask portion having one or more open channels, sealed channels, and/or a sealed chamber exposing an active surface of the microfluidic sensor. The molded panel portions and mask portions are configured to allow a material to dynamically or statically contact the microfluidic sensor for analysis. | 02-12-2015 |
20150060283 | DNA SEQUENCING USING A SUSPENDED CARBON NANOTUBE - A technique is provided for forming a nanodevice for sequencing. A bottom metal contact is disposed at a location in an insulator that is on a substrate. A nonconducting material is disposed on top of the bottom metal contact and the insulator. A carbon nanotube is disposed on top of the nonconducting material. Top metal contacts are disposed on top of the carbon nanotube at the location of the bottom metal contact, where the top metal contacts are formed at opposing ends of the carbon nanotube at the location. The carbon nanotube is suspended over the bottom metal contact at the location, by etching away the nonconducting material under the carbon nanotube to expose the bottom metal contact as a bottom of a trench, while leaving the nonconducting material immediately under the top metal contacts as walls of the trench. | 03-05-2015 |
20150101933 | TRANSLOCATION AND NUCLEOTIDE READING MECHANISMS FOR SEQUENCING NANODEVICES - By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are strategically placed around or above a nanopore. Changes in transmission spectra and input voltage detected by electrodes allow accurate identification of single molecules as they pass through a nanopore. | 04-16-2015 |
20150107998 | PRINTED DIGITAL MICROFLUIDIC DEVICES METHODS OF USE AND MANUFACTURE THEREOF - Embodiments of the present disclosure digital microfluidic arrays that may be fabricated by a printing method, whereby digital microfluidic electrodes arrays are printed, via a printing method such as inkjet printing, onto a suitable substrate. In some embodiments, a substrate and/or ink is prepared or modified to support the printing of electrode arrays, such as via changes to the surface energy. In some embodiments, porous and/or fibrous substrates are prepared by the addition of a barrier layer, or, for example, by the addition or infiltration of a suitable material to render the surface capable of supporting printed electrodes. Various example embodiments involving hybrid devices formed by the printing of digital microfluidic arrays onto a substrate having a hydrophilic layer are disclosed. | 04-23-2015 |
20150122655 | TWO-DIMENSIONAL FLUID SEPARATION WITH CONTROLLED PRESSURE - A sample separation apparatus ( | 05-07-2015 |
20150314293 | Droplet Actuator Devices and Methods Employing Magnetic Beads - A method of providing a droplet in contact with a magnetically responsive bead and having a reduced quantity of a substance. The method generally includes the steps of (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged for conducting droplet operations on a surface; (ii) a starting droplet comprising: (1) one or more magnetically responsive beads; (2) a starting quantity of the substance; and (3) a starting volume; (b) magnetically immobilizing the one or more magnetically responsive beads at a location which is at a distance from a target droplet splitting zone; (c) conducting one or more droplet operations comprising droplet dividing operations selected to divide the combined droplet to yield a set of droplets comprising: (i) a droplet comprising substantially all of the one or more magnetically responsive beads and having a decreased quantity of the substance relative to the starting concentration; and (ii) a droplet substantially lacking the magnetically responsive beads. | 11-05-2015 |
20150323498 | DEVICES FOR EXTRACTING AT LEAST ONE ANALYTE - A device for extracting at least one analyte may include: a sample reservoir configured to contain a sample comprising at least one target analyte and interfering materials; at least one extraction chamber connected to the sample reservoir; at least one porous structure lining one or more sides of the at least one extraction chamber; and a voltage source configured to provide a first voltage and a second voltage, wherein, when the first voltage is provided, the at least one target analyte and the interfering materials move towards the at least one extraction chamber or to a predetermined area from the at least one extraction chamber, wherein, when the second voltage is provided, the interfering materials pass through and exit the at least one extraction chamber, and the at least one target analyte is stopped from exiting the at least one extraction chamber by means of the at least one porous structure. | 11-12-2015 |
20150323499 | Artificial Sieving Structures - Disclosed herein is a device for electrophoresis comprising: a separation channel in a substrate; and a plurality of capillary-well motifs cascading along the separation channel, each of the plurality of capillary-well motifs comprising a well and a plurality of non-intersecting capillaries, wherein the capillaries are downstream from the well and fluidly connected thereto, an interface between the well and the capillaries comprises a step profile. Also disclosed is a method comprising: obtaining a substrate comprising an insulator layer of an insulator material; forming a well and a plurality of trenches in the insulator layer so that only the insulator material is exposed to an interior of the well and the plurality of trenches; nonconformally depositing a film into the plurality of trenches until the film pinches off top openings of the trenches and forms a tubular void therein; transforming the tubular void into a capillary by annealing the film. | 11-12-2015 |
20150343442 | REVERSIBLE BONDING OF MICROFLUIDIC CHANNELS USING DRY ADHESIVES - A reversible bonded microfluidic structure comprises an overhanging cap or gasket structure atop a continuous microfluidic channel wall. An overhanging gasket structure may reduce stress concentrations at the edge of the channel wall and can permit improved reversible adhesion of the channel wall and adjacent dry adhesive fibers. In one example, reversible adhesion of the overhanging channel wall gasket and adjacent dry adhesive fibers may approach 1 MPa in axial loading. An overhanging gasket structure of the microfluidic channel wall may comprise a single “fiber” that is continuous around the perimeter of the desired microfluidic channel shape, and may define a self-sealing gasket which will contain fluid. The overhanging gasket structure may be surrounded by further overhanging or undercut dry adhesive fibers to enhance the adhesion and help make the rest of the surface more tolerant to defects and surface roughness. | 12-03-2015 |
20150346151 | CAPILLARY ELECTROPHORESIS SYSTEM - The invention is an improved multiplex capillary electrophoresis instrument or module with at least four and preferably six user-accessible vertically stacked drawers. An x-z stage moves samples from the user accessible drawers to the capillary array for analysis. A computer program allows users to add capillary electrophoresis jobs to a queue corresponding to the analysis of rows or plates of samples without stopping or interrupting runs in progress. | 12-03-2015 |
20150368635 | MICROFLUIDIC DEVICES TO EXTRACT, CONCENTRATE AND ISOLATE MOLECULES - Methods, systems, and devices are disclosed for capturing, concentrating, and isolating molecules in a fluid. In one aspect, a device includes a substrate formed of a material that is electrically insulating, a microfluidic channel made of an electrically insulating material formed on the substrate to carry a biofluid containing molecules including nucleic acids, an array of electrodes formed on the surface along a parallel direction of the microfluidic channel constituting a capture region, in which the array of electrodes are operable to produce an electric field across the microfluidic channel that creates an electrostatic attractive force on the nucleic acids to immobilize them in the capture region, and a chamber formed on the substrate of the electrically insulating material and connected to the microfluidic channel, the chamber configured to have a volume less than that of the microfluidic channel, in which, when the nucleic acids are released from immobilization in the capture region, the released nucleic acids are collected in the chamber. | 12-24-2015 |
20160003798 | APPARATUSES AND METHODS FOR DETERMINING ANALYTE CHARGE - The present disclosure provides a sensor including a pore and an applied electric field that is capable of detecting analytes such as nucleic acids. In accordance with various embodiments, the sensor comprises a fluidic chamber having electrically opposing portions with a membrane between, the membrane providing a pore suitable for the passage of an electrolyte between the electrically opposing portions of the fluidic chamber, and having at least one charged analyte tethered in proximity to the pore, a first circuit configured to apply an electric field capable of passing the electrolyte through the pore and pulling the at least one charged analyte into the pore, and a second circuit configured to measure a signal indicative of the charge of the at least one charged analyte. Also provided are methods for using the sensor, for example, to sequence a nucleic acid molecule. | 01-07-2016 |
20160016170 | MICROFLUIDICS CARTRIDGE WITH PIPETTING GUIDE - A disposable cartridge configured as a digital microfluidics system for manipulating samples in liquid portions having a cartridge accommodation site and a central control unit for controlling selection of individual electrodes of an electrode array located at the site and for providing plural electrodes with individual voltage pulses for manipulating liquid portions by electrowetting. The cartridge has a hydrophobic working surface and a rigid cover with a second hydrophobic surface, the hydrophobic surfaces facing each other and being separated in parallel planes by a gap. The cartridge has plural pipetting guides for safe entering/withdrawing liquids into/from the gap with a pipette tip. At least one of the pipetting guides provides an abutting surface sealingly admittable by a counter surface of a pipette tip, located at a pipetting orifice that reaches through the rigid cover, and configured to prevent a pipette tip from touching the hydrophobic working surface. | 01-21-2016 |
20160016403 | Droplet Actuator Devices and Methods - A microfluidic device having a substrate with an electrically conductive element made using a conductive ink layer underlying a hydrophobic layer. | 01-21-2016 |
20160067706 | MANIPULATION OF OBJECTS IN MICROFLUIDIC DEVICES USING EXTERNAL ELECTRODES - The invention provides microfluidic devices, systems, and methods for manipulating an object within a channel of a microfluidic device using an external electrode. The device has a channel disposed within the device, the channel having no included electrodes. The channel has a wall, at least a portion of which is penetrable by an electric field generated external to the device, the wall being penetrable such that the electric field extends through the wall portion and into a region within the channel. The system includes the microfluidic device and an electrode external to and not bonded to the device. In the method, the external electrode is placed adjacent to the device and energized to generate an electric field that extends through the wall of the device and into the channel, thereby manipulating an object within the channel. | 03-10-2016 |
20160084748 | MICROCHIP FOR SORTING MICRO PARTICLES AND CARTRIDGE INCLUDING SAME - A microchip is provided that includes a flow path through which a liquid containing a micro particle flows, an orifice through which the liquid flowing through the flow path is discharged into a space outside the microchip, and a light-irradiated portion provided at a predetermined location of the flow path and configured to be irradiated with light. A width of the flow path and a depth of the flow path at the orifice are set to be smaller than a width of the flow path and a depth of the flow path at the light-irradiated portion, and the flow path is configured to gradually decrease from upstream of the orifice in a cross-section area perpendicular to a liquid-delivering direction between the light-irradiated portion and the orifice. A cartridge including the microchip is also provided. | 03-24-2016 |
20160097739 | System for Detection of Analytes - Embodiments provide analyte detection systems for detecting the presence of one or more analytes in one or more samples. An exemplary detection system includes at least one channel for accommodating a sample and a sensor compound, the channel having a width and a length that is significantly greater in dimension than the width. An exemplary detection system includes an analyte detection circuit programmed or configured to detect one or more electrical properties along at least a portion of the length of the channel to determine whether the channel contains an analyte of interest. | 04-07-2016 |
20160139079 | Molecular Characterization Device - Provided is a solid state support structure including an aperture having a molecular entrance and a molecular exit. A first reservoir is in fluidic communication with the molecular entrance of the aperture and contains a molecule-bearing liquid solution. A second reservoir is in fluidic communication with the molecular exit of the aperture for containing a molecule-bearing liquid solution. A first liquid channel is connected to the first reservoir within less than about 300 microns of the aperture in the support structure and includes molecule-bearing liquid solution for delivery to the first reservoir. A second liquid channel is connected to the second reservoir for accepting molecule-bearing liquid solution from the second reservoir. An electrical connection between the first reservoir and the second reservoir imposes an electrical bias between the first reservoir and the second reservoir for driving the molecule-bearing liquid solution through the aperture in the solid state support structure. | 05-19-2016 |
20160139105 | DNA SEQUENCING USING MULTIPLE METAL LAYER STRUCTURE WITH DIFFERENT ORGANIC COATINGS FORMING DIFFERENT TRANSIENT BONDINGS TO DNA - A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds. | 05-19-2016 |
20160153935 | MICROANALYSIS CHIP | 06-02-2016 |
20160177383 | NANOCHANNEL WITH INTEGRATED TUNNEL GAP | 06-23-2016 |
20160187295 | SEMICONDUCTOR MICRO-ANALYSIS CHIP AND METHOD OF MANUFACTURING THE SAME - According to one embodiment, a semiconductor micro-analysis chip for detecting particles in a sample liquid includes a semiconductor substrate, a flow channel provided on a surface portion of the semiconductor substrate to allow the sample liquid to flow in the channel, and including a cap layer to cover at least an upper portion of the flow channel, a micropore provided at a part of the flow channel to allow the particles in the sample liquid to pass through the micropore, and a plurality of holes provided in the cap layer. | 06-30-2016 |
20160375440 | THREE-DIMENSIONAL MULTIPLE-LAYER MICROFLUIDIC MICRO-DROPLET ARRAYS FOR CHEMICAL AND BIOCHEMICAL MICROREACTORS, MINIATURE BIOREACTORS, HEAT TRANSFER, AND OTHER APPLICATIONS - A microfluidic transport system for transporting microdroplets in three spatial dimensions among layers of a layered microfluidic system. In an example arrangement, a first microfluidic layer for transporting microdroplets in two spatial dimensions responsive to electric fields created by electrical operation of electrodes is fluidically connected by one or more conduits to other microfluidic layers. Microdroplets can be transported through the one or more conduits so as to be moved among a plurality of layered microfluidic arrangements. The resulting layered system can be used for heat transfer, fluidic transfer, and other uses, and can be implemented using materials such as metal, glass, polymer, plastic, layered materials, fibrous materials, etc. In some applications the layered system can be implemented within a printed circuit board, integrated circuit housing. Example applications include integrated circuit cooling, energy harvesting, microfluidic processing systems, chemical reactors, biochemical reactors, chemical analysis arrangements, biochemical analysis arrangements, and other apparatus. | 12-29-2016 |
20170234833 | Increasing the Capture Zone by Nanostructure Patterns | 08-17-2017 |
20180024095 | NON-THERMOSENSITIVE MEDIUM FOR ANALYZING SPECIES IN A CHANNEL AND FOR MINIMIZING ADSORPTION AND/OR ELECTROOSOMOSIC PHENOMENA | 01-25-2018 |
20190143105 | ELECTROPHORETIC ACTIVE DELIVERY SYSTEM INCLUDING POROUS CONDUCTIVE ELECTRODE LAYER | 05-16-2019 |