Class / Patent application number | Description | Number of patent applications / Date published |
128832000 | With contraceptive, spermacidal, or antifertility agent | 42 |
20120073578 | LOW-DOSE TRANSDERMAL PATCHES WITH HIGH DRUG RELEASE - The present invention relates to the field of pharmaceutical formulation techniques. The invention provides a low dosage pharmaceutical composition for transdermal delivery of hormones, preferably a progestin, such as a Gestodene, and an estrogen, preferably Ethinylestradiol so as to achieve plasma concentration profiles effective in inhibiting ovulation in a woman. | 03-29-2012 |
20130220337 | DEVICES AND METHODS FOR INTRAVAGINAL DELIVERY OF DRUGS AND OTHER SUBSTANCES - The present technology provides intravaginal devices designed to intravaginally deliver difficult to formulate water-soluble molecules and macromolecules for a sustained period of time. The devices include a chamber having at least one orifice and containing a sustained-release formulation. Such formulations include a water-swellable polymer and an intravaginally administrable substance. Methods of making and using the devices are also provided. | 08-29-2013 |
20140109916 | Transdermal Delivery of Hormones without the Need of Penetration Enhancers - The present invention relates to a patch comprising a drug-containing layer with low content of hormones, such as gestodene, and optionally an estrogen (e.g. ethinyl estradiol). Upon administering the patch to a woman, plasma levels of at least 1.0 ng/ml of Gestodene is achieved at steady state conditions without the need of incorporating penetration enhancers or permeation enhancers in the drug-containing layer. Satisfactorily plasma levels of the hormones is also achieved throughout a period of at least 1 week, making the patch applicable for being used in female contraception with the concept of administering the patch ones weekly. | 04-24-2014 |
20140182597 | TRANSDERMAL DRUG DELIVERY SYSTEMS FOR LEVONORGESTREL AND ETHINYL ESTRADIOL - Described are transdermal drug delivery systems for the transdermal administration of levonorgestrel and ethinyl estradiol, comprising an acrylic polymer matrix. Methods of making and using such systems also are described. | 07-03-2014 |
20140209100 | INTRAVAGINAL DEVICES FOR DRUG DELIVERY - Intravaginal drug delivery devices, including intravaginal rings, are provided herein. The devices include a reservoir of at least one vaginally administrable drug wherein the reservoir is surrounded at least in part by a hydrophilic elastomer. The devices are capable of exhibiting a substantially zero order release profile of drug over extended periods of time. Also disclosed are methods for making the devices and methods of using the devices to prevent or treat a biological condition. | 07-31-2014 |
20150136143 | COMBINATION THERAPY INTRAVAGINAL RINGS - The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of dapivirine in combination with either an antimicrobial compound or a contraceptive to a human. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, methods of preventing unintended pregnancy in a female human, and methods of preparing intravaginal rings. | 05-21-2015 |
128833000 | Intrauterine | 36 |
20090056723 | Ultrasonically Detectable Intrauterine System and a Method for Enhancing Ultrasound Detection - The present invention relates to ultrasonically detectable intrauterine systems and to a method for enhancing ultrasound detection of these systems. An intrauterine system having an inert metal coating on at least part of the body of the intrauterine system or at least one inert metal clip, pin, ring or sleeve fixedly positioned on the body of the intrauterine system is described. | 03-05-2009 |
20110017219 | INTRAUTERINE DEPOSIT - An intrauterine system ( | 01-27-2011 |
20110056501 | INTRAUTERINE SYSTEM - The present invention relates to novel intrauterine systems and to methods for manufacturing these systems. An intrauterine system according to the invention comprises a reservoir and a continuous, closed and flexible frame. | 03-10-2011 |
20110146693 | INTRAUTERINE DELIVERY SYSTEM FOR CONTRACEPTION - The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time. | 06-23-2011 |
20110253148 | PLASTIC FRAME FOR AN INTRAUTERINE DEVICE - An intrauterine device for delivering bioactive substances in the uterine cavity includes a plastic frame affixed to a drug delivery compartment. In use, the frame retains the IUD in the uterine cavity and prevents displacement and expulsion. The frame is shaped like the letter “omega” having two resilient arms which possess latero-lateral memory. The extremities of the arms are provided by a short side-arm which forms an angle with the rest of the arm. These prominent plastic parts facilitate the upward rotation of the arms during removal of the intrauterine device. Due to the resilience of the arms, the frame adapts to cavities of every size, maximizing tolerance. The drug delivery compartment has an element at its upper extremity to determine the exact location of the IUD in the uterine cavity by ultrasound. The drug delivery compartment contains one or more drugs which are gradually released in the uterine cavity over extended periods of time. | 10-20-2011 |
20110271963 | NOVEL INTRA UTERINE DEVICE - The present invention discloses an Intra Uterine Ball (IUB) device useful for a gynecological procedure or treatment. The aforesaid device comprises a hollow sleeve for at least partial insertion into the uterine cavity; and, an elongate conformable member with at least a portion comprised of shape memory alloy. The elongate member is adapted to be pushed out from said sleeve within said uterine cavity. It is the core of the invention that the elongate member is adapted to conform into a predetermined three dimensional ball-like configuration within said uterine cavity following its emergence from said sleeve, such that expulsion from said uterine cavity, malposition in said uterine cavity, and perforation of the uterine walls is prevented. | 11-10-2011 |
20120097172 | INTRAUTERINE DEVICE - An intrauterine device for applying force to a wall of a uterus to promote contraception without blocking the fallopian tubes may include an elongate member formed of a resilient material and having a default expanded configuration and a spring portion disposed approximately at a midpoint between two ends of the elongate member. The IUD may also include two tissue contact members, one tissue contact member disposed at one of the two ends of the elongate member and the other tissue contact member disposed at the other end. The tissue contact members may generate a laterally directed force against the wall of the uterus when the intrauterine device assumes its default expanded configuration. | 04-26-2012 |
20120111338 | INTRAUTERINE DEVICE AND INSERTER FOR THE SAME - An inserter for placing a T-shaped intrauterine device inside a patient's uterus and a T-shaped intrauterine device are disclosed. The inserter includes a sleeve part and a plunger part, the sleeve part includes a tube and a first engaging member and the plunger part includes a rod, a handle attached to the rod and a second engaging member. The first and the second engaging members are configured for reversibly engaging the sleeve part and the plunger part to temporarily lock the relative position between the tube and the rod. The T-shaped intrauterine device includes a pair of wings having a relaxed extended configuration and a contracted folded configuration and an elongated contraceptive body suspended from a junction between the wings. | 05-10-2012 |
20120318276 | FRAMELESS INTRAUTERINE DEVICES AND SYSTEMS - A frameless copper-releasing contraceptive IUD or a hormone-releasing contraceptive IUS, includes a suture thread ( | 12-20-2012 |
20130014763 | INTRAUTERINE DEPOSIT - An intrauterine system for the retention of a biologically active compound within the uterus of a female mammal is formed by a frame defining an interior space for receipt of a deposit of the compound. The frame has an open structure allowing access to a substantial part of an outer surface of the deposit and the deposit has a rate controlling structure that controls a rate of release of the compound within the uterus. Retention elements are provided on the frame for retaining the frame within the uterus. | 01-17-2013 |
20130074846 | INTRAUTERINE DEVICE, METHOD OF MAKING SUCH A DEVICE AND METHOD FOR PUTTING ACTIVE ELEMENTS WITHIN THE UTERINE CAVITY - A retrievable intrauterine device for placing within the uterine cavity one or more encapsulated elements ( | 03-28-2013 |
20130133667 | INTRA-UTERINE SYSTEM - Intra-uterine system for inserting an active substance in an uterus, wherein the system comprises two flexible arms that extend from a central part in essentially mutually opposed directions, and retention means for the active substance, wherein during use the system is entered into the uterus, wherein an elongated housing extends from the central part at essentially equal angles with the flexible arms, wherein the housing comprises a storage container as retention means for the active substance, an outlet opening, a pump system, a control unit for controlled pumping of the active substance from the storage container through the outlet opening into the uterus and a energy storage means for supplying energy to the pump system and to the control unit. | 05-30-2013 |
20130269705 | VARIABLE STIFFNESS FLEXURE - An intrauterine device includes a central support member, first and second internal flexures and first and second external flexures. The first and second internal flexures each include a first section having a first stiffness, a second section having a second stiffness, and third section having a third stiffness, wherein the second stiffness is more flexible than the first and third stiffness and wherein the first section of each internal flexure is coupled to the central support member. The first and second external flexures are coupled to the central support member and coupled to the third sections of the first and second internal flexures, the first and second external flexures in combination with the first and second internal flexures being configured to extend from a collapsed position parallel to the central support member to a deployed position flexing away from the central support member. | 10-17-2013 |
20130269706 | BARREL-SHAPED VAGINAL RING - The present invention relates to annular intravaginal devices comprising an aperture, methods of making, and uses thereof. The annular devices comprise an aperture extending into the device, the aperture having: (a) an interior diameter, and (b) an exterior entry diameter, wherein the exterior entry diameter of the aperture is less than the interior diameter of the aperture. | 10-17-2013 |
20130319424 | INTRAUTERINE DEVICE AND INSERTER FOR THE SAME - An inserter for placing a T-shaped intrauterine device inside a patient's uterus and a T-shaped intrauterine device are disclosed. The inserter includes a sleeve part and a plunger part, the sleeve part includes a tube and a first engaging member and the plunger part includes a rod, a handle attached to the rod and a second engaging member. The first and the second engaging members are configured for reversibly engaging the sleeve part and the plunger part to temporarily lock the relative position between the tube and the rod. The T-shaped intrauterine device includes a pair of wings having a relaxed extended configuration and a contracted folded configuration and an elongated contraceptive body suspended from a junction between the wings. | 12-05-2013 |
20130327338 | INTRA-UTERINE DEVICE AND RELATED METHODS - An intrauterine device includes an elongate member; and a flexible arm having a first end and a second end, wherein the first end is operatively coupled to the elongate member at a first location, and wherein the second end is operatively coupled to the elongate member at a second location, and wherein the flexible arm is adjustable between a closed configuration, in which the flexible arm is closely apposed to the elongate member, and an open configuration, in which the flexible arm extends away from the elongate member, and wherein the flexible arm is biased to be in the closed configuration. | 12-12-2013 |
20140041667 | Intra Uterine Device For An Animal And A System For Loading The Intra Uterine Device Into A Delivery Gun - A system for delivering an IUD into an animal, including: (i) an IUD for a an animal, comprising: (a) a main body; and (b) a pair of bendable arms extending away from the main body, wherein the ends of the bendable arms fold together in a direction away from the main body; (ii) a delivery gun for inserting the IUD into an animal, wherein the delivery gun comprises a tubular barrel and a plunger moveable within the tubular barrel; and (iii) a loading gun for inserting the IUD into the tubular barrel of the delivery gun, wherein the loading gun is configured to insert the IUD into the delivery gun with the pair of bendable arms being folded together forward of the main body of the IUD. | 02-13-2014 |
20140048073 | INTRAUTERINE CONTRACEPTIVE DEVICE - A method for promoting contraception by placing a contraceptive device within a uterus without blocking fallopian tubes may involve advancing a distal end of a delivery device through a cervix, advancing the contraceptive device comprising an elongate shape memory member out of the distal end of the delivery device and into the uterus, and limiting inferior migration of the contraceptive device within the uterus. Inferior migration may be limited by allowing the contraceptive device to assume a shape, when subjected to pressure that tends to cause a downward migration of the device within the uterus, in which an expandable middle portion of the device is expanded to contact the inner wall of the uterus and thus limit the downward migration of the device. | 02-20-2014 |
20140048074 | INTRAUTERINE CONTRACEPTIVE DEVICE - A method for promoting contraception by placing a contraceptive device within a uterus without blocking fallopian tubes may involve advancing a distal end of a delivery device through a cervix, advancing the contraceptive device comprising an elongate shape memory member out of the distal end of the delivery device and into the uterus, and limiting inferior migration of the contraceptive device within the uterus. Inferior migration may be limited by allowing the contraceptive device to assume a shape, when subjected to pressure that tends to cause a downward migration of the device within the uterus, in which an expandable middle portion of the device is expanded to contact the inner wall of the uterus and thus limit the downward migration of the device. | 02-20-2014 |
20140076327 | METHOD FOR MAKING A RESERVOIR CONTAINING AN ACTIVE SUBSTANCE DIFFUSED THROUGH THE RESERVOIR AND INSTALLATION THEREFOR - The invention concerns a method for making a reservoir ( | 03-20-2014 |
20140076328 | INSERTER - The present invention relates to an inserter for an intrauterine system comprising a handle ( | 03-20-2014 |
20140261444 | INTRAUTERINE CONTRACEPTIVE DEVICES - A contraceptive intrauterine device having a support structure configured for transcervical implantation in a uterus, an active element coupled to the support structure, the active element having a core including copper that is at least partially coated with an outer layer including gold or gold alloy. A contraceptive intrauterine device having a support structure configured for transcervical implantation in a uterus, an active element coupled to the support structure, the active element including a copper core that is at least partially plated or coated with an outer layer including gold or gold alloy, wherein the copper core is configured to release copper ions after the device is implanted in a uterus, and wherein the gold or gold alloy outer layer is configured to control the release rate of copper ions release by the core. Methods for preventing conception by implanting said contraceptive intrauterine devices. | 09-18-2014 |
20140283844 | Intra-Uterine Contraceptive Device - The present invention relates to an improved intra-uterine contraceptive device (IUCD) characterized by comprising polymer based material | 09-25-2014 |
20150068532 | INTRAUTERINE DEVICE - An intrauterine device for applying force to a wall of a uterus to promote contraception without blocking the fallopian tubes may include an elongate member formed of a resilient material and having a default expanded configuration and a spring portion disposed approximately at a midpoint between two ends of the elongate member. The IUD may also include two tissue contact members, one tissue contact member disposed at one of the two ends of the elongate member and the other tissue contact member disposed at the other end. The tissue contact members may generate a laterally directed force against the wall of the uterus when the intrauterine device assumes its default expanded configuration. | 03-12-2015 |
20150101613 | INTRAUTERINE DEVICE WITH CONTROLLED COPPER ION ELUTION - An intrauterine contraceptive device may include a frame made completely or partially of a first metal having a first galvanic potential and at least one metallic member coupled with the frame that is made of a second metal having a second galvanic potential different from the first galvanic potential. In some embodiments, the first galvanic potential may be more anodic than the second galvanic potential. In alternative embodiments, the first galvanic potential may be more cathodic than the second galvanic potential. In one embodiment, the first metal is Nitinol, and the second metal is copper. In some embodiments, the first and second galvanic potentials may be configured to achieve, at least approximately, a desired copper ion elution rate for the intrauterine device. | 04-16-2015 |
20150107598 | INTRAUTERINE DEVICE WITH RETRIEVAL THREAD - An intrauterine contraceptive system may include a contraceptive intrauterine device, a retrieval thread permanently attached to the intrauterine device and an insertion device for inserting the intrauterine device into a uterus. The system may also include a release thread releasably coupled with the intrauterine device. The intrauterine device may be deployable out of a distal end of the insertion device and may be configured to change from a delivery configuration when housed in the insertion device to a deployed configuration when deployed in a uterus. The retrieval thread and the optional release thread may be at least partially housed within the insertion device during insertion of the intrauterine device into the uterus. The release thread may extend from the intrauterine device through the insertion device to an attachment point at or near a proximal end of the insertion device. | 04-23-2015 |
20150305922 | INTRAUTERINE DEVICE WITH RETRIEVAL THREAD - An intrauterine contraceptive system may include a contraceptive intrauterine device, a retrieval thread permanently attached to the intrauterine device and an insertion device for inserting the intrauterine device into a uterus. The system may also include a release thread releasably coupled with the intrauterine device. The intrauterine device may be deployable out of a distal end of the insertion device and may be configured to change from a delivery configuration when housed in the insertion device to a deployed configuration when deployed in a uterus. The retrieval thread and the optional release thread may be at least partially housed within the insertion device during insertion of the intrauterine device into the uterus. The release thread may extend from the intrauterine device through the insertion device to an attachment point at or near a proximal end of the insertion device. | 10-29-2015 |
20150313753 | INTRAUTERINE CONTRACEPTIVE DEVICE - A method for promoting contraception by placing a contraceptive device within a uterus without blocking fallopian tubes may involve advancing a distal end of a delivery device through a cervix, advancing the contraceptive device comprising an elongate shape memory member out of the distal end of the delivery device and into the uterus, and limiting inferior migration of the contraceptive device within the uterus. Inferior migration may be limited by allowing the contraceptive device to assume a shape, when subjected to pressure that tends to cause a downward migration of the device within the uterus, in which an expandable middle portion of the device is expanded to contact the inner wall of the uterus and thus limit the downward migration of the device. | 11-05-2015 |
20150335464 | INTRAUTERINE DEPOSIT - An intrauterine system for the retention of a biologically active compound within the uterus of a female mammal is formed by a frame defining an interior space for receipt of a deposit of the compound. The frame has an open structure allowing access to a substantial part of an outer surface of the deposit and the deposit has a rate controlling structure that controls a rate of release of the compound within the uterus. Retention elements are provided on the frame for retaining the frame within the uterus. | 11-26-2015 |
20150335465 | INTRAUTERINE CONTRACEPTIVE DEVICE - A method for promoting contraception by placing a contraceptive device within a uterus without blocking fallopian tubes may involve advancing a distal end of a delivery device through a cervix, advancing the contraceptive device comprising an elongate shape memory member out of the distal end of the delivery device and into the uterus, and limiting inferior migration of the contraceptive device within the uterus. Inferior migration may be limited by allowing the contraceptive device to assume a shape, when subjected to pressure that tends to cause a downward migration of the device within the uterus, in which an expandable middle portion of the device is expanded to contact the inner wall of the uterus and thus limit the downward migration of the device. | 11-26-2015 |
20150359663 | COPPER-RELEASING HYBRID IUD WITH ADAPTABLE RETENTION ARM CONNECTED TO FRAMELESS BODY - A new and improved hybrid “framed-frameless” copper-releasing contraceptive device (IUD) which is a combination of a plastic retention arm of reduced dimensions to adapt to uterine cavities of smaller size, particularly regarding their transverse width at the fundal level of the uterus, and whose retention arm has a centrally located extension of varying length to be connected with hollow copper tubes which functions as the frameless stem of the IUD, and which consists of loosely connected hollow tubes, threaded on a length of suture, or a thin plastic or metallic stem, or a thin polymeric drug eluting stem, allowing release of copper ions, from the outside and from the inside of the tubes, in the uterine cavity thereby enhancing the contraceptive effect, and of which the bottom tube, is crimped onto the lower end of the stem, including a separate metallic ion-releasing fiber, holding all copper tubes together. | 12-17-2015 |
20150359890 | AN INTRAUTERINE DEVICE, AND A METHOD OF REDUCING THE RATE OF DIFFUSION OF ACTIVE INGREDIENTS IN SAID INTRAUTERINE DEVICE - An intrauterine device having at least one first pharmaceutically active ingredient and at least one first layer made of at least a first polymeric material, wherein between about 10 and about 60 v/v % of at least one particulate material is dispersed and/or incorporated in the first polymeric material. The presence of the particulate material will reduce the porosity of the polymer or otherwise obstruct the diffusion of the pharmaceutically active ingredient being released, thereby slowing its rate of release. In this way, it is possible to regulate the release rate and/or initial burst of the device, simply by adjusting the amount of particles/particulate material in the first layer, instead of having to adapt the size of the device to the desired release pattern, which requires expensive changes in production equipment and manufacturing processes. | 12-17-2015 |
20160015557 | Variable Stiffness Flexure - An intrauterine device includes a central support member, first and second internal flexures and first and second external flexures. The first and second internal flexures each include a first section having a first stiffness, a second section having a second stiffness, and third section having a third stiffness, wherein the second stiffness is more flexible than the first and third stiffness and wherein the first section of each internal flexure is coupled to the central support member. The first and second external flexures are coupled to the central support member and coupled to the third sections of the first and second internal flexures, the first and second external flexures in combination with the first and second internal flexures being configured to extend from a collapsed position parallel to the central support member to a deployed position flexing away from the central support member. | 01-21-2016 |
20160058608 | INTRAUTERINE DEVICE - An intrauterine device for applying force to a wall of a uterus to promote contraception without blocking the fallopian tubes may include an elongate member formed of a resilient material and having a default expanded configuration and a spring portion disposed approximately at a midpoint between two ends of the elongate member. The IUD may also include two tissue contact members, one tissue contact member disposed at one of the two ends of the elongate member and the other tissue contact member disposed at the other end. The tissue contact members may generate a laterally directed force against the wall of the uterus when the intrauterine device assumes its default expanded configuration. | 03-03-2016 |
20160058609 | INTRAUTERINE DEVICE WITH RETRIEVAL THREAD - An intrauterine contraceptive system may include a contraceptive intrauterine device, a retrieval thread permanently attached to the intrauterine device and an insertion device for inserting the intrauterine device into a uterus. The system may also include a release thread releasably coupled with the intrauterine device. The intrauterine device may be deployable out of a distal end of the insertion device and may be configured to change from a delivery configuration when housed in the insertion device to a deployed configuration when deployed in a uterus. The retrieval thread and the optional release thread may be at least partially housed within the insertion device during insertion of the intrauterine device into the uterus. The release thread may extend from the intrauterine device through the insertion device to an attachment point at or near a proximal end of the insertion device. | 03-03-2016 |
20160136402 | DRUG DELIVERY SYSTEM FOR ONE OR MORE ACTIVE INGREDIENTS - A drug delivery system that includes an elongated inert support and at least two reservoirs containing a pharmaceutically active ingredient. The inert support has a number of wall segments that define at least two compartments arranged for accommodating the at least two reservoirs. The inert support is made of a material which prevents migration or diffusion of the active ingredient from one reservoir into the other or into the support. Since the drug delivery system is divided into compartments, one for each reservoir containing an active ingredient, the release rates of each active ingredient can be independently controlled or adjusted. This is due to the fact that there is no interaction between the active ingredients, and accordingly the active ingredients will not influence each other physically or chemically. | 05-19-2016 |