Entries |
Document | Title | Date |
20080216562 | Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof - Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof. | 09-11-2008 |
20080229809 | Sample Injection Device, Sample Injection Method, and Liquid Chromatograph - The present invention relates to a sample injection device, a sample injection method, and a liquid chromatograph that control the flow of a mobile phase using a switching valve. The sample injection device includes a port connected to a separation column, a pump for supplying a mobile phase, first and second sample injection needles, a syringe, and a valve configured to selectively connect the first sample injection needle to the pump or the syringe and to connect the second sample injection needle to the pump. When the first sample injection needle is attached to the port, the first sample injection needle is connected to the pump through operation of the valve. When the second sample injection needle is attached to the port, the first sample injection needle is connected to the syringe and the second sample injection needle is connected to the pump. | 09-25-2008 |
20080229810 | Sample Injector, in Particular for High-Power Liquid Chromatography - The invention relates to a device for feeding samples to a separating device and for collecting sample fractions generated by means of the separating device, especially for high-performance liquid chromatography, with a first switch valve unit ( | 09-25-2008 |
20080236256 | Device and Method For Sample Preparation - A system and method for sample preparation and/or sample enrichment are provided. The system comprises the following components: a first switch element with a switch element input and at least two mutually exclusive switch element outputs and a second corresponding switch element with at least two mutually exclusive switch element inputs and a switch element output, the first and second switch elements being connected to control means for opening and closing the switch element inputs and switch element outputs; a first distributor element with at least three ports and a second distributor element with at least three ports; as well as a first separation column and a second separation column, the components being in such fluidic communication with each other that by means of different positions of the switch elements it is possible to configure at least two different fluidic paths in the system, wherein said different positions are achievable through the control means. The system allows, for example, the simple performance of the backflush process. | 10-02-2008 |
20080257019 | Method of Analyzing Phosphorous Acid, Fosetyl-Al, or Both Simultaneously - Method for analyzing one or more pesticidal compounds present in amounts of less than or equal to 5 mg/kg of a sample, comprising the following steps:
| 10-23-2008 |
20080314129 | LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY - A liquid chromatography/mass spectrometry system includes a chromatographic column through which an effluent passes, wherein the effluent comprises a plurality of analytes that correspond to a plurality of chromatographic peaks and an eluent; a post-column splitter having at least two output ports through which the effluent of the column is split to at least a first portion and a second portion; a mass spectrometer configured to receive the first portion from a first of the output ports for analysis; and a tube connected to a second of the output ports configured to prevent substantial evaporation of the eluent in the second portion until undergoing mass spectrometry. The second portion has a plurality of separated analytes corresponding to at least two chromatographic peaks. A method of using the system is also disclosed. | 12-25-2008 |
20090000358 | Method of Analysis Using Chromatographic Pre-Separation - The present invention relates to a method for analysing a fluid, comprising applying the fluid to a pre-separation module and subjecting the fluid to a chromatographic pre-separation, taking a sample from said zone; and subjecting said sample to an analytical separation. The invention further relates to an apparatus for analysing a fluid, suitable for carrying out a method according to the invention. | 01-01-2009 |
20090044607 | METHOD AND DEVICE FOR DRAWING A VOLUME OF LIQUID BY SUCTION, IN PARTICULAR FOR COLLECTING A SAMPLE FOR ANALYSIS BY MEANS OF A LIQUID CHROMATOGRAPHY DEVICE - The invention relates to a method for drawing a liquid volume, in particular for drawing a sample for analysis by means of a liquid chromatography device, wherein the liquid comprising the liquid volume to be withdrawn is provided in a container | 02-19-2009 |
20090078031 | LIQUID CHROMATOGRAPH AND SAMPLE INTRODUCING APPARATUS - Disclosed herein is a sample introducing apparatus which is designed such that the analytical flow path runs from the needle to the separation column without the flow path switching means placed at the downstream side of the needle. This design reduces dead volume, which in turn reduces the diffusion of the sample injected into the analytical flow path. Moreover, the absence of the flow path switching means at the downstream side of the needle to inject a sample into the analytical flow path eliminates connection of the pipe with the flow path switching means. This prevents the sample from remaining in the connecting part, thereby reducing sample carry-over and improving the accuracy of analysis. | 03-26-2009 |
20090090173 | LIQUID CHROMATOGRAPHY APPARATUS AND LIQUID CHROMATOGRAPHY ANALYSIS METHOD - An object of the present invention is to improve the accuracy in analysis repeatability of a liquid chromatography apparatus that feeds different eluent by use of a plurality of pumps and achieves the mixture of eluent. | 04-09-2009 |
20090126466 | Methods for Separating Compounds - Methods and systems for analyzing samples using multi-dimensional chromatography are disclosed. | 05-21-2009 |
20090126467 | WASHING DEVICE FOR LIQUID CHROMATOGRAPHY INJECTORS - The invention concerns a device for washing the injector in a liquid chromatography equipment, comprising a sealed passage for the injection needle and, upstream, a mobile valve for alternatively connecting said passage with the outside for introduction of the needle, or with at least one source of washing fluid. | 05-21-2009 |
20090139310 | Vented filter for automatic HPLC loop loading - A vented filter is placed at the HPLC (High Performance Liquid Chromatography) loop entry port of an HPLC injector valve. The vented filter prevents the push gas used to deliver the crude radiolabeled product from over-pushing the liquid to waste. Push gas is vented off when the entire crude liquid product has passed through the vented filter and been loaded onto the HPLC loop. | 06-04-2009 |
20090145204 | METHOD AND DEVICE FOR INGREDIENT ANALYSIS - A method for ingredient analysis includes the steps of: providing a database, which stores a plurality of standard ingredient data; analyzing a sample to obtain a plurality of inspection data via a high performance liquid chromatography (HPLC) method; and respectively comparing the inspection data with the corresponding standard ingredient data to analyze all ingredients contained in the sample simultaneously. The method may be applied to a device for ingredient analysis. Thus, by cooperating the database with the HPLC method, all ingredients contained in the sample can be analyzed via at least one analysis procedure so that the procedures for ingredient analysis are simpler and quicker and the accuracy of the analysis result can be enhanced. | 06-11-2009 |
20090145205 | AUTOSAMPLER FOR HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY - The invention relates to an autosampler for high-performance liquid chromatography (HPLC) with a high-pressure injection valve ( | 06-11-2009 |
20090211345 | Method for the detection of lateral flow assay and strip and laser-induced epifluorescence and compact scanner therefor - Disclosed is a lateral flow quantitative assay method capable of quantitatively determining the concentration and analyzing the spatial distribution of a disease marker by employing the principle of the laser-induced fluorescence detection technique, which is based on detecting emitted fluorescence when laser light is focused to the disease marker deposited onto a lateral flow quantitative assay chip. The present invention discloses a strip, a laser-induced epifluorescence detection device and a small scanner for the assay method. The present assay method is advantageous in terms of allowing quantitative point-of-care diagnostics in hospitals, being capable of specifically detecting a disease marker by optimizing a lateral flow assay biochip for diagnosis of a specific disease, allowing more accurate quantitative analysis of analytes, and being capable of simultaneously analyzing several cancer markers, reducing the hook effect and expanding the detection range and accurately measuring concentration of analytes. | 08-27-2009 |
20090211346 | Methods for Detecting Alzheimer's Disease - Markers are provided that are predictive of Alzheimer's disease. Levels of these markers, when different from a standard, are indicative of a patient being at risk of having or developing Alzheimer's disease. | 08-27-2009 |
20090217742 | DROPLET COMPARTMENTALIZATION FOR CHEMICAL SEPARATION AND ON-LINE SAMPLING - Methods and devices are provided for overcoming detrimental diffusive effects in a sample liquid stream by forming segmented liquid bodies (e.g., droplets) from a sample liquid stream in an immiscible liquid stream. The liquid bodies are formed at the intersection of a channel providing the sample liquid stream and a channel providing the immiscible liquid stream. The formed liquid bodies compartmentalize the portion of the sample liquid stream from which the liquid bodies are formed, thus minimizing the detrimental effects of diffusion that occur in a continuous liquid stream. | 09-03-2009 |
20090277255 | Real-Time, On-Line Analysis for the Quantification of Trihalomethane Species Within Drinking Water Supplies - Separating trihalomethanes from drinking water samples (via a process such as capillary membrane sampling, and the like) followed by gas chromatograph analysis to determine quantity measurements and species identification of such trihalomethane (THM4) contaminants therein is provided. With the necessity to chlorinate drinking water to remove harmful bacteria and other potential toxins, trihalomethane byproducts are generated that may harm humans after consumption as well due to suspect carcinogenicity of such compounds. A reliable manner of measuring such drinking water supplies for such THM4 contaminants at locations far from the source and closer to dispensers is highly desirable. The ability to separate the THM4 from the drinking water sample, followed by a gas chromatography or like manner of quantifying and identifying the THM4 compounds possibly present within the drinking water sample has been found to be nearly as reliable as federally mandated source measuring methods for the same purpose, but with the versatility to measure for such trihalomethane contaminants anywhere along the drinking water supply line. | 11-12-2009 |
20090320572 | THE QUANTITATIVE DETERMINATION OF RISEDRONATE IN URINE BY SPE-LC-MS-MS - The present invention is directed to a SPE-LC-MS-MS method for quantitatively determining risedronate in a urine sample. | 12-31-2009 |
20100000301 | LIQUID CHROMATOGRAPH - Disclosed herein is a liquid chromatograph in which a fractionation flow path, a non-fractionation flow path, a concentration flow path, and a secondary analysis flow path can be provided by operating flow path switching valves and flow path selecting valves. The concentration flow path and either one of the fractionation flow path and the non-fractionation flow path can be provided at the same time, and the secondary analysis flow path and either one of the fractionation flow path and the non-fractiontation flow path can also be provided at the same time. | 01-07-2010 |
20100000302 | Process for preparing forms of atorvastatin calcium substantially free of impurities - The preparation of atorvastatin calcium epoxide dihydroxy (AED) is described. AED can be used as a standard or marker in determining the amount of AED in a sample. AED can therefore be used as a tool in preparing atorvastatin calcium substantially free of AED. | 01-07-2010 |
20100043539 | DEVICE AND METHODS FOR REDUCING PRESSURE AND FLOW PERTURBATIONS IN A CHROMATOGRAPHIC SYSTEM - Embodiments of the present invention are directed to methods and apparatus for placing a sample in a chromatographic system. The device and method feature placing samples held in a sample loop to pressurization prior to placing such sample loop in communication with high pressure conduits. | 02-25-2010 |
20100050749 | Sample preparation apparatus - A capture and purification apparatus is configured as a stand-alone apparatus or as part of a larger system. The capture and purification apparatus can be configured as a microfluidic cartridge that includes microfluidic circuitry and individually controlled valves. The microfluidic cartridge can be configured to function independently, or can be configured to be coupled to a separate instrument that provides the actuation to perform the capture and purification process. The capture and purification apparatus is configured as a volume-driven system that applies single-direction valves, a single fluid driving device, and fluid lines to control and discretely direct fluid flow within a full-loaded fluidic system. Such control enables various fluid sample processing techniques to be performed including, but not limited to, lysis, thermal cycling, and/or target analyte capture and purification, for example using a combination of ion-exchange chromatography and size-exclusion chromatography (SEC). | 03-04-2010 |
20100071444 | High Throughput Screening, Purification and Recovery System for Large and Small Molecules - The present invention relates to a method and apparatus for chromatographically analyzing/purifying samples in a detector, comprising an autosampler to contain a sample for chromatographic analysis and a chromatographic system comprising a loading pump, and an eluting pump and at least one chromatography column. A detector is included for detecting compounds in the sample from the chromatography system. The loading pump establishes a flow of a loading solvent through the autosampler to dissolve the sample and to load the sample on the chromatography column. The eluting pump establishes a flow of eluent of increasing strength through the column and to the detector. In addition, the present invention provides improved methods of screening and preparative chromatography. | 03-25-2010 |
20100089134 | HPLC PUMPING APPARATUS WITH SILICON CARBIDE PISTON AND/OR WORKING CHAMBER - A pumping apparatus for a high performance liquid chromatography system ( | 04-15-2010 |
20100126255 | DEVICE AND METHOD FOR SEPARATION OF PROTEINS AND OTHER BIOMOLECULES - The present invention relates to a device and method for separation of proteins and other biomolecules. A preferred use is for sample preparation of crude as well as pre-fractionated samples. In a preferred embodiment, the device of the present invention is a pipette tip having dual channels, one for inlet of sample and one for outlet. The outlet, but not the inlet, channel is provided with sample separation media for separation of a desired biomolecule from a sample. The flow through the sample separation media is unidirectional. | 05-27-2010 |
20100229634 | METHOD FOR ANALYSIS OF SACCHARIDES - Disclosed is an improved post-column fluorimetric determination-boric acid complex anion exchange method which allows analysis of mannose-6-phosphate. The disclosed method is a method for separation analysis of reducing sugars using column chromatography, comprising loading a sample onto an anion exchange column, washing the column by allowing to flow a sufficient volume of a first mobile phase consisting of an aqueous solution of a predetermined concentration of boric acid containing a predetermined concentration of a water-soluble inorganic salt through the column, supplying a second mobile phase with an elevated concentration of the salt to elute the reducing sugars, adding to the eluate a basic amino acid, heating, and continuously measuring and recording the intensity of fluorescent light emitted under irradiation with excitation light. | 09-16-2010 |
20100229635 | METHODS AND APPARATUS FOR CENTRIFUGAL LIQUID CHROMATOGRAPHY - Apparatus and methods related to centrifugal liquid chromatography are described. An angular velocity can be simultaneously imparted to a large number of chromatographic enclosures. Via centrifugal forces, a mobile phase fluid including a sample can be driven through a stationary phase within the chromatographic enclosure to perform a chromatographic separation process on components of the sample. The use of centrifugation as a driving force can allow significantly smaller stationary phase particles to be employed as compared to high performance liquid chromatography (HPLC). Further, for an equivalent chromatographic separation process, the use of centrifugation can provide much greater separation efficiencies than HPLC. | 09-16-2010 |
20100269573 | LOSSLESS DROPLET TRANSFER OF DROPLET-BASED MICROFLUIDIC ANALYSIS - A transfer structure for droplet-based microfluidic analysis is characterized by a first conduit containing a first stream having at least one immiscible droplet of aqueous material and a second conduit containing a second stream comprising an aqueous fluid. The interface between the first conduit and the second conduit can define a plurality of apertures, wherein the apertures are sized to prevent exchange of the first and second streams between conduits while allowing lossless transfer of droplets from the first conduit to the second conduit through contact between the first and second streams. | 10-28-2010 |
20100288025 | SAMPLE INJECTOR FOR LIQUID CHROMATOGRAPHY, PARTICULARLY FOR HIGH PERFORMANCE LIQUID CHROMATOGRAPHY - The invention pertains to a sample injector for liquid chromatography, particularly for high performance liquid chromatography, with a controllable injection valve ( | 11-18-2010 |
20100307227 | Multi Column Chromatography System - The present invention relates to a method and apparatus for chromatographically analyzing each of a plurality of samples in detector, comprising an autosampler to contain a plurality of samples for chromatographic analysis and a pluraltity of chromatographic systems, each system comprising one or more pumps and one or more chromatographic columns. A detector is included for detecting compounds in the samples from each of the chromatography systems along with a valve positioned between the detector and the plurality of chromatography systems, the valve permitting each sample to reach the detector in sequence. A computer control device is included which adjusts the introduction of samples from the autosampler into the plurality of chromatography systems as well as the position of the valve to sequentially separate and deliver compounds within the samples to the detector. | 12-09-2010 |
20110016955 | Sample Dilution for Chromatography of Multiple Process Streams - A method of liquid chromatography includes providing an injection valve, drawing a sample and a diluent while mixing, pushing the mixed sample and diluent onto a sample loop of the injection valve, and injecting the mixed sample and diluent. An analytical apparatus includes a proportioning unit, an injection valve having a sample loop, and a sample pump. The injection valve has a draw state and a load state, and has a port in fluidic communication with an outlet port of the proportioning unit. The sample pump is in fluidic communication with the outlet port of the proportioning unit, if the injection valve is in the draw state, to draw both a sample and a diluent through the proportioning unit and the injection valve, and in fluidic communication with the sample loop, if the injection valve is in the load state, to push the drawn sample and diluent onto the sample loop. | 01-27-2011 |
20110079076 | MOLECULAR MARKERS FOR AUTISM - The invention relates to the determination of phosphorylation levels of some specific salivary peptides (statherin, histatin 1, acidic proline-rich proteins, both in whole form (PRP-1 type) and in truncated form (PRP-3 type) as a non-invasive diagnostic marker with a >40% sensitivity for defining autism spectrum disorders (ASDs) patients, methods for performing said determination, a kit for the non-invasive diagnosis of at least 40% of autism cases, containing means for such a determination, and the use of such a determination for therapeutical research on autism. | 04-07-2011 |
20110100099 | PREPARATION AND USE OF (R),(R)-2,2'-BIS-METHYLNALTREXONE - This invention relates to synthesis of (R),(R)-2,2′-bis-MNTX, as shown in Formula (I), and related methods and products. | 05-05-2011 |
20110120213 | SAMPLE INJECTOR, SAMPLE INJECTING METHOD, AND LIQUID CHROMATOGRAPH - A sample injection part connected to a column to inject a sample into the column; a sample injection needle attachable to the sample injection part; a sample suction part connectable to the sample injection needle and configured to cause a predetermined amount of the sample to be drawn by suction into the sample injection needle upon connecting to the sample connection needle; a mobile phase supply part configured to supply the column with a mobile phase; a first switching valve for selectively connecting the sample injection needle to one of the sample suction part and the mobile phase supply part; and a second switching valve, including the sample injection part, for supplying the sample and the mobile phase to the column via the sample injection needle in the case of having the sample injection needle attached to the sample injection part and for supplying the mobile phase to the column via the first switching valve in the case of having the sample injection needle removed from the sample injection part are included. | 05-26-2011 |
20110167898 | LIQUID CHROMATOGRAPH - A liquid chromatograph provided here is adapted to enable the lengths of tubing for connecting the respective constituent elements thereof to be minimized by making the positions of the respective constituent elements including a detector and a column movable and adjustable in order to reduce the dead volume in a liquid chromatograph system in plumbing and increase the analytical precision through prevention of diffusion of samples and rapid sending of a mixed liquid solvent. Furthermore, in order to prevent cross-contamination due to residues of samples and cleaning liquid in a flow channel of the liquid chromatograph system, an injection port in which a needle can be inserted is so provided as to communicate directly with a flow channel of an injection valve. | 07-14-2011 |
20110174063 | MULTICHANNEL ION CHROMATOGRAPHY SYSTEM AND METHOD - An ion chromatography housing for easy insertion and removal of a plurality of component cartridges is disclosed. Various components of the IC system are provided in the separate component cartridges. The IC housing includes a capillary separation column and may be connected to conventional-scale components of an IC system. A plurality of IC housings may be provided in a compartment with one or more separation columns. The columns may be capillary columns or conventional-scale columns. A method of using the ion chromatography system is also disclosed. The IC system may be utilized to perform two-dimensional ion chromatographic separation. | 07-21-2011 |
20110179855 | METHODS FOR DETECTING VITAMIN C BY MASS SPECTROMETRY - Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample. | 07-28-2011 |
20110185796 | CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF - The present invention provides compounds which are useful, e.g., as reference markers for analyzing the purity of cisatracurium and salts thereof, a test method for determining the said purity and processes for preparing reference markers. | 08-04-2011 |
20110192217 | Flow Distribution Mixer - A mixer for mixing a fluid having a property varying along a flow direction of the fluid includes an inlet configured for receiving an inlet flow, an outlet configured for providing an outlet flow, and a plurality of flow channels coupled between the inlet and the outlet. The mixer also includes a flow distributor for distributing the inlet flow into the plurality of flow channels so that each flow channel receives a partial flow from the inlet flow, and a flow combiner for combining the partial flows from the plurality of flow channels to the outlet flow. Each flow channel has a first flow section having a hydraulic resistance substantially representing a hydraulic resistance of the flow channel. One or more of the flow channels each have a second flow section coupled in series with the first flow section of the respective flow channel. | 08-11-2011 |
20110197661 | APPARATUS FOR SAMPLE HANDLING - A sampler ( | 08-18-2011 |
20110219859 | Analyzing System For Liquid Chromatograph and Control Program For the Same System - The present invention provides an analyzing system with which a serial analysis inclusive of a pretreatment can be easily performed in a liquid chromatograph, and even unskilled users can perform a desired analysis. The analyzing system according to the present invention includes: an edit screen display section | 09-15-2011 |
20110239745 | Rapid Identification of Explosives Using Thin-Layer Chromatography and Colorimetric Techniques - A thin-layer chromatography method for identifying material present in a sample on a location including the steps of provide a thin-layer chromatography plate, wetting a swab is with a solvent providing a wetted swab, contacted the location of interest is with the wetted swab to obtain the sample providing a wetted swab with sample, placing the wetted swab with sample in the solvent to dissolve the sample and provide a solvent with sample, dipping a micropipette into the solvent with sample to obtain an amount of the solvent with sample, spotting the amount of the solvent with sample on the thin-layer chromatography plate, allowed the amount of the solvent with sample on the thin-layer chromatography plate to dry providing a thin-layer chromatography plate with sample, placing the a thin-layer chromatography plate with sample into a developing chamber with solvent mixture, allowing the thin-layer chromatography plate with sample to develop producing a developed thin-layer chromatography plate with sample, removing the developed thin-layer chromatography plate with sample from the developing chamber, and illuminating the developed thin-layer chromatography plate with sample with ultra violet light to produce an image for identifying the material present in the sample. | 10-06-2011 |
20110247403 | Apparatus And Methods For Multidimensional Analysis - The invention provides improved methods and apparatus for multidimensional analysis, especially for multidimensional liquid chromatography. Methods and apparatus for the quantitative determination of one or more components comprised in a sample mixture are described. Methods and apparatus of the invention typically allow accurate quantitative determination of more components of the mixture than prior multidimensional methods. The invention is particularly useful for, but is not limited to the analysis of complex mixtures of peptides and proteins. | 10-13-2011 |
20110247404 | IDENTIFYING AND QUANTIFYING BIOMARKERS ASSOCIATED WITH PREECLAMPSIA - Described herein are methods for testing pregnant subjects for preeclampsia by detecting and quantifying at least one biomarker associated with preeclampsia in a biological sample from the subject. | 10-13-2011 |
20110247405 | Sample Injection Port and Auto-Sampler Having the Same - A sample injection port | 10-13-2011 |
20110265557 | Method of Quality Control Testing a Factor XIII Containing Sample - The invention relates to a method of quality control testing a Factor XIII (FXIII) containing sample which comprises the step of detecting the presence of and/or measuring the concentration of pre-activated FXIII (FXIIIao) in said sample and to a quality control kit for determining the quality of a Factor XIII (FXIII) containing sample. Preferably, an anion-exchange chromatographic column is used, as well as the fluorescent substrate Abz-NE (Cad-Dnp) EQVS PLTLLK-OH. | 11-03-2011 |
20110290009 | NARROW BORE POROUS LAYER OPEN TUBE CAPILLARY COLUMN AND USES THEREOF - A polymer-based PLOT capillary column prepared by in situ copolymerization of a functional monomer, which usually contains the retentive chemistries, and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Also disclosed is a system comprising the polymer-based PLOT column coupled to a mass flow or concentration sensitive detector, for carrying out a chemical analysis method on samples separated by liquid chromatography using the column, and a process for using the system. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 μm. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power and high column-to-column reproducibility. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems are capable of detecting the component parts of complex proteomic samples down to the low attomole to sub-attomole level. | 12-01-2011 |
20120006104 | High Temperature Chromatography Apparatus and Method Thereof - Disclosed herein are a high temperature chromatography apparatus and a method thereof. The high temperature chromatography apparatus includes: an eluent pump; a sample dissolving unit that uniformly dissolves an insoluble sample; an injecting unit that mixes and injects the sample and the eluent; a column unit that separates materials; a detector that detects materials; a temperature measuring unit that measures the temperature of the sample dissolving unit, the injecting unit, and the column unit; a heating device that increases or decreases the temperature of the sample dissolving unit, the injecting unit, and the column unit; a temperature controller that maintains the measured temperature and the setting temperature to be the same as each other; and a controller. | 01-12-2012 |
20120024048 | LIQUID CHROMATOGRAPH - In injecting a sample sucked into a sample loop in an autosampler from an injection needle into an analytical flow path via an injection port by a mobile phase, a sending flow rate of the mobile phase is reduced from a certain flow rate determined in an analysis condition to reduce pressure applied on a joint section between the needle and the injection port to thereby reduce the sample remaining in the injection port. | 02-02-2012 |
20120103074 | Automated Analyzer with Low-Pressure In-Line Filtration - An automated analyzer for biological samples that contain particulate matter is adapted to be able to process a large number of samples without changing the analytical cartridge, and in many cases without changing the internal switching valves, by including a filter in the low-pressure section of the analyzer, and preferably configuring the analyzer to be able to perform backflushing on the filter between sample injections. | 05-03-2012 |
20120103075 | Automated Dilution For Liquid Chromatography - Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced. | 05-03-2012 |
20120111098 | 2- ACETAMIDE - The invention relates to 2-{2-amino-3-[hydroxy(phenyl)methyl]phenyl}acetamide, a process for its preparation, and its use as a reference marker and reference standard for analyzing the purity of nepafenac. | 05-10-2012 |
20120204626 | SAMPLE INJECTOR FOR LIQUID CHROMATOGRAPH - A sample injection apparatus includes a sample container and a tube that communicates with the inlet of a liquid chromatographic column. The sample container receives at least a preparatory-sized sample. A syringe pump pulls sample from the sample container and applies it to the inlet of the liquid chromatographic column. | 08-16-2012 |
20120222469 | Apparatus and Procedure For In Vitro Measurement of a Substance, Nicotine, Released From a Smokeless Tobacco Product - An apparatus ( | 09-06-2012 |
20120227469 | CHROMATOGRAPHY OF POLYOLEFIN POLYMERS - The invention provides a method for one-dimensional chromatography of a polyolefin polymer, comprising introducing a solution of the polyolefin polymer into a liquid flowing through a liquid chromatography stationary phase, the liquid chromatography stationary phase comprising graphitic carbon, and wherein the polyolefin polymer emerging from the liquid chromatography stationary phase has a retention factor greater than zero, and wherein the solution introduced into the liquid chromatography stationary phase is subjected to a temperature gradient, and/or the solution is subjected to a solvent gradient. The invention also provides a method for multi-dimensional chromatography of a polyolefin polymer, comprising introducing a solution of the polyolefin polymer into a liquid flowing through a first liquid chromatography stationary phase or a field flow fractionation device, and subsequently flowing the solution through a second liquid chromatography stationary phase, the second liquid chromatography stationary phase comprising graphitic carbon, and wherein the polyolefin polymer emerging from the liquid chromatography stationary phase has a retention factor greater than zero. The invention also provides an apparatus for polyolefin polymer chromatography, comprising a liquid chromatography stationary phase, the liquid chromatography stationary phase comprising graphitic carbon and at least one inert filler. | 09-13-2012 |
20120279284 | LIQUID CHROMATOGRAPH AND SAMPLE INTRODUCING APPARATUS - Disclosed herein is a sample introducing apparatus which is designed such that the analytical flow path runs from the needle to the separation column without the flow path switching means placed at the downstream side of the needle. This design reduces dead volume, which in turn reduces the diffusion of the sample injected into the analytical flow path. Moreover, the absence of the flow path switching means at the downstream side of the needle to inject a sample into the analytical flow path eliminates connection of the pipe with the flow path switching means. This prevents the sample from remaining in the connecting part, thereby reducing sample carry-over and improving the accuracy of analysis. | 11-08-2012 |
20120291531 | LIQUID CHROMATOGRAPH AND LIQUID FEEDER FOR LIQUID CHROMATOGRAPH - Provided is a liquid chromatograph of a gradient type capable of promoting the mixture of a plurality of solvents without increasing flow passage volume. To this end, the liquid chromatograph includes: a Pump configured to suck a plurality of solvents and feed the solvents to a sample injection device, a separation column that separates a sample to be analyzed into components; and a detector that detects a component of the sample fed from the separation column. The Pump is configured to suck the plurality of solvents through an intake port and feed the solvents to a sample injection device through a discharge port and mix the plurality of solvents at between the intake port and the discharge port. The Pump further includes a cylinder and a plunger that reciprocates inside the cylinder, and the cylinder has an inner wall provided with a recess to generate a whirl in the plurality of solvents. | 11-22-2012 |
20120304745 | COORDINATION OF SOLVENT DELIVERY WITH PRE-INJECTION OPERATIONS IN A LIQUID CHROMATOGRAPH - A liquid chromatography system includes an autosampler that prepares a sample for introduction to a solvent stream and a solvent delivery system that delivers a solvent stream to the autosampler. Delivery of the solvent stream occurs in parallel with the autosampler's pre-injection operations. The autosampler starts pre-injection operations to make the sample ready for injection into the mixture stream, and the solvent delivery system starts delivery of a solvent stream to the autosampler. The start of the solvent stream delivery is coordinated with the start of the pre-injection operations such that the solvent stream arrives at the autosampler approximately coincident with when the autosampler completes the pre-injection operations, making the sample ready for injection. | 12-06-2012 |
20120312081 | High-Performance Liquid Chromatograph Apparatus and Method for Feeding Liquid to High-Performance Liquid Chromatograph Apparatus - A high-performance liquid chromatograph apparatus of the present invention can obtain a similar separation effect as that obtained in a constant velocity gradient elution method and shorten a measuring time. When a data processor ( | 12-13-2012 |
20130008239 | Soot Bench Test - The dispersibility of soot in a lubricant formulation containing a dispersant is evaluated by (a) preparing a dispersion of carbon black in the lubricant formulation; (b) depositing a sample of the dispersed carbon black from step (a) onto a planar chromatography medium; (c) subjecting the sample of (b) to chromatographic conditions and (d) evaluating the extent of migration of the carbon black by comparing the density of darkening due to carbon black at pre-defined locations along the chromatography medium. The liquid mobile chromatography phase comprises a mixture of a liquid non-aromatic hydrocarbon portion having viscosity and boiling point less than that of an oil of lubricating viscosity; and an oil component comprising an oil of lubricating viscosity and the dispersant or dispersants that are also contained within the lubricant formulation. | 01-10-2013 |
20130014566 | Method for Automatic Optimization Of Liquid Chromatography Autosampler - An method for optimizing operation of an autosampler coupled to a liquid chromatography (LC) system comprises: reading, from electronic memory storage, a pre-injection time corresponding to the time required for the autosampler to perform operations preparatory to injecting a sample; calculating an autosampler delay time from the pre-injection time and from a sample analysis time; performing the autosampler operations preparatory to injecting the sample after delaying said autosampler operations for the autosampler delay time; measuring a time value for the preceding performing of autosampler operations; replacing the pre-injection time value stored on the electronic memory storage with the measured time value for the preceding performing of autosampler operations if the measured value is greater than the pre-injection time value stored on the electronic memory storage; and injecting the sample from the autosampler into the LC system after receipt of a signal from the LC system by the autosampler. | 01-17-2013 |
20130014567 | CHROMATOGRAPHY APPARATUS HAVING DIFFUSION-BONDED AND SURFACE-MODIFIED COMPONENTS - A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick. | 01-17-2013 |
20130042673 | Methods and Apparatus for Analyzing Samples and Collecting Sample Fractions - Methods and apparatus for analyzing a sample using at least one detector are disclosed. | 02-21-2013 |
20130061662 | APPARATUS AND METHOD FOR POLYMER CHARACTERIZATION - Apparatus for GPC/TREF and TREF/GPC characterization of a polymer sample. The apparatus provides for the automated and integrated use of multiple TREF columns and a GPC system employing a multiple flow through detectors. In addition, a method for TREF/GPC characterization of a polymer sample by GPC analysis of TREF fractions at increasing TREF elution temperatures from multiple TREF columns operated in a coordinated and synchronized temperature cycle for increased sample throughput. Also, a method for GPC/TREF characterization of a polymer sample by GPC fractionation followed by TREF fractionation of the GPC fractionations. | 03-14-2013 |
20130067997 | SINGLE INJECTION VALVE FOR HPLC COMBINING SAMPLE INTRODUCTION, WASH CYCLES AND DIAGNOSIS - A switchable valve for a sample injector includes a first valve member and a second valve member that can moved with respect to the other. The first valve member includes a plurality of ports, the second valve member includes a plurality of fluid paths. The plurality of ports include eight circumferential ports distributed along a circumference and one central port arranged at a central position of the first valve member. The plurality of fluid paths include three arcuate fluid paths so as to be couplable with at least two of the circumferential ports and one straight fluid path extending between the central position and a circumferential position so as to be couplable with the central port and one of the circumferential ports. | 03-21-2013 |
20130091933 | LIQUID MIXING DEVICE AND LIQUID CHROMATOGRAPH - A liquid mixing device that decreases a concentration non-uniformity in the flow direction of a mobile phase and a liquid chromatograph that uses the liquid mixing device are provided. The liquid mixing device is configured to include a flow channel unit that is made from an introduction channel, a branch portion that is positioned in a downstream of the introduction channel, multiple branched flow channels that branch from the branch portion, a junction portion in which the multiple branched flow channels join together, and a discharge channel of the downstream of the junction portion. The multiple branched flow channels are different in terms of any one of, or several of width, depth, and length that are associated with an external shape, and a structure filling the inside of the flow channel and thus the times for the liquid to pass through the branched flow channels are different from each other. | 04-18-2013 |
20130091934 | BLOOD COLLECTION MODULE FOR MEASURING ALCOHOL CONCENTRATION - A blood collection module includes a blood collection container that is coupled with a blood alcohol concentration detection device including an alcohol detection sensor having a detection probe that inhales an alcohol gas, and on one surface of which an inserting portion that is inserted by a detection probe of a blood alcohol concentration detection device is formed and on an outer surface of which blood inlet holes through which blood flows in are formed; and an absorption member that is provided in the blood collection container, to thus absorb examinee's blood that is introduced through the blood inlet holes, in which an alcohol gas generated from the blood absorbed by the absorption member is introduced into the alcohol detection sensor through the detection probe. | 04-18-2013 |
20130174651 | PROCESS FOR PREPARATION OF SUBSTANTIALLY PURE FOSAMPRENAVIR CALCIUM AND ITS INTERMEDIATES - The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R) tetrahydro -3 -furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof. | 07-11-2013 |
20130186187 | NANOFLOW DETECTOR CELL - A nanoflow detector cell comprises a nanoflow detection cell template defming a sample channel transverse template and a reference channel transverse template, generally parallel to the sample channel, and spaced apart from the sample channel. Clear capillary tubing extends through the sample channel, defming a sample chamber, a portion of the capillary tubing extends out of each end of the sample channel, and is shaped to the template. | 07-25-2013 |
20130220000 | DEVICE AND METHOD FOR SEPARATION OF PROTEINS AND OTHER BIOMOLECULES - The present invention relates to a device and method for separation of proteins and other biomolecules. A preferred use is for sample preparation of crude as well as pre-fractionated samples. In a preferred embodiment, the device of the present invention is a pipette tip having dual channels, one for inlet of sample and one for outlet. The outlet, but not the inlet, channel is provided with sample separation media for separation of a desired biomolecule from a sample. The flow through the sample separation media is unidirectional. | 08-29-2013 |
20130276519 | Methods of Separating Compounds - Methods for chromatography for metal compounds are disclosed herein. These methods relate to introducing an analyte solution into a chromatographic system comprising a liquid phase flowing through a solid stationary phase, wherein the solid stationary phase comprises graphitic carbon; and eluting compounds from the stationary phase with a retention factor greater than zero, wherein a chromatogram of the eluted compounds shows that the compounds are substantially resolved. Methods for determining the purity of mixtures of metal compounds are also disclosed. | 10-24-2013 |
20130298647 | FITTING ELEMENT WITH BIO-COMPATIBLE SEALING - A fitting element is configured for coupling tubing to a fluidic device having a receiving cavity configured for receiving the fitting element, where the tubing has an inner contact surface of a biocompatible material, the inner contact surface being configured to contact a fluid to be conducted by the tubing, and the receiving cavity having a receiving contact surface of a bio-compatible material. The fitting element includes a first sealing element of a bio-compatible material configured for sealing to the bio-compatible material of the inner contact surface of the tubing, and a second sealing element configured for sealing against a pressure ambient to a pressure of the fluid in the tubing. Upon coupling of the tubing to the fluidic device, at least a portion of the receiving contact surface, the first sealing element, and the second sealing element enclose an interspace, each surface of the interspace being a bio-compatible material. | 11-14-2013 |
20130312500 | CO2-REMOVAL DEVICE AND METHOD - An electrolytic CO | 11-28-2013 |
20130319087 | BUBBLE REDUCTION DEVICE, CHROMATOGRAPHY DEVICE, BUBBLE REDUCTION METHOD, AND BUBBLE REDUCTION PROGRAM - A bubble reduction device, chromatography device, bubble reduction method and bubble reduction program capable of reducing bubbles in an eluent. Included are a liquid accommodation portion, a liquid supply apparatus, an air layer formation apparatus, a first channel and an evacuation portion. The liquid accommodation portion accommodates a liquid that is to elute an analysis component from a specimen adsorbed to an adsorption portion. The liquid supply apparatus, by operation of a rod pushing up and polling down, sucks and discharges the liquid through an aperture portion of a tube portion, the aperture portion being oriented upward. The air layer formation apparatus forms an air layer in the tube portion. The first channel connects the liquid supply apparatus with the liquid accommodation portion. The evacuation portion is connected to the first channel via a first switching valve and evacuates the air layer through the first channel. | 12-05-2013 |
20130319088 | LIQUID CHROMATOGRAPHY APPARATUS, LIQUID CHROMATOGRAPHY ANALYSIS METHOD, AND LIQUID CHROMATOGRAPHY ANALYSIS PROGRAM - A liquid chromatography apparatus having: a column that adsorbs analysis components within a specimen; a plunger pump that feeds eluent A, that elutes the analysis components adsorbed at the column, in an amount greater than or equal to an amount needed for analysis of one specimen from a cylinder portion by a one-time pushing operation of a rod; a photometric unit that analyzes analysis components eluted by eluent A; an eluent loop that holds eluent B; a liquid feeding flow path that communicates the plunger pump and the column; and a first switching valve that switches the liquid feeding flow path to either of a first flow path, that causes eluent A to flow from the plunger pump to the column, and a second flow path, that causes eluent A to flow from the plunger pump through the first eluent holding loop to the column, is provided. | 12-05-2013 |
20130327129 | SPECTROSCOPIC SAMPLE INSPECTION FOR AUTOMATED CHROMATOGRAPHY - A method and a system for generating an extraction sample from a dried sample spot. The method includes acquiring a spectroscopic image of an analyte in the spot. The spectroscopic image includes information on a spatial distribution of the analyte. A region of the spot to be extracted is determined from the spectroscopic image and an extraction sample is generated from the determined region. In other embodiments, the method and system are based on acquiring a spectroscopic measurement of an analyte in the dried sample spot, determining a quantity of the analyte in the spot based on the spectroscopic measurement and determining a volume of an extraction solvent for creating an extraction sample from the spot. The determined volume is based on the determined quantity of the analyte and a detection characteristic of an analytical measurement system. In other embodiments, the method is applied to solid samples. | 12-12-2013 |
20140020455 | Analyzing Apparatus Control System And Program For The Same - The present invention aims at providing an analyzing apparatus control system which is capable of appropriately setting the conditions of measurement in an analyzing apparatus which is connected to a chromatograph, in which one more measurement events are performed based on a reference chromatogram. This system includes a measurement time range setting section for setting, for each of all peaks or previously selected peak or peaks included in a previously provided reference chromatogram which corresponds to the sample to be examined, the width of a peak as the measurement time range of the peak when the peak does not overlap another peak, or, when the peak overlaps another peak, the overall width of the peak and the overlapping peak as the measurement time range of the peak. | 01-23-2014 |
20140033805 | METHODS OF EXTRACTING FAT SOLUBLE VITAMINS - The present invention provides novel, simple and reliable methods for extraction of fat soluble vitamins (FSVs) from a sample matrix obtained from food products (e.g., vitamin-enriched foods and fortified food matrices) or biological samples. In certain aspects, the invention provides solid phase extraction (SPE) methods. In certain embodiments, the invention relates to two-step elution methods, which provide excellent recovery of all fat-soluble vitamins from complicated food matrices (such as, vitamin-enriched foods and fortified food products) or biological samples in a simultaneous manner. In certain embodiments, the invention uses OASIS® materials as sorbent beds for separating and/or extracting FSVs from the sample matrix. | 02-06-2014 |
20140047906 | LC-MS CONFIGURATION FOR PURIFICATION AND DETECTION OF ANALYTES HAVING A BROAD RANGE OF HYDROPHOBICITES - Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system. The methods, systems, and kits described herein provide for substantially increased speed/throughput and ease of use for a wide range analytes with essentially no compromise in specificity for individual analytes relative to previously described methods. | 02-20-2014 |
20140047907 | Cartridge with Multiple Electrospray Emitters - An apparatus includes a portable housing and a plurality of separately operable microfluidic emitters disposed within the housing. Each microfluidic emitter h an inlet for receiving a liquid and an outlet for emitting a spray. Each microfluidic emitter is movable within the portable housing between a first position in which the outlet of that microfluidic emitter is fully retracted within the portable housing and a second position in which the outlet of that microfluidic emitter projects out of the portable housing. The portable housing with the multiple emitters is adapted to be detachably coupled to another housing portion. This housing portion includes a microfluidic substrate with a channel for transporting an eluent and an outlet aperture for emitting the eluent. The inlet of one of the emitters is detachably coupled to the outlet aperture of the microfluidic substrate. | 02-20-2014 |
20140069176 | MULTI-COMPONENT ELUENT GENERATING SYSTEM AND METHOD - A system and method to generate a concentration gradient eluent flow are described. The concentration gradient eluent flow can include at least two different generants. A liquid can be pumped to an eluent generating device. A first controlling signal can be applied to a first eluent generator to generate a first generant. A second controlling signal can be applied to a second eluent generator to generate a second generant. Either the first and/or the second controlling signal can be varied as a function of time to generate the concentration gradient eluent flow. | 03-13-2014 |
20140096597 | Apparatuses and Methods for Wireless Monitoring and Control of Environmental Sampling and Chromatographic Apparatuses - A liquid chromatographic system includes columns, column mounting fixtures to which the columns are mounted, a detector, a collector, a controller and a plurality of RFIDs. A first RFID communicates with the controller and cooperating RFIDs mounted to other components provide information such as the history of components, parameters and the like. They also receive information from sensors relating to the operation of the liquid chromatograph, store the information and transmit it. Moreover, the RFIDs may substitute for hard wiring in many applications and may enable a central computer to control several liquid chromatographic and environmental sample collectors. | 04-10-2014 |
20140123736 | FP PREPARING METHOD, FP PREPARING PROGRAM, FP PREPARING DEVICE, AND FP - An evaluating apparatus includes a FP preparing part that prepares a target FP configured by peaks, retention time points and UV spectra thereof detected from a 3D chromatogram of a multicomponent drug that is an evaluation target at a specific wavelength. | 05-08-2014 |
20140130581 | METHOD FOR DETERMINING THE EFFECTIVENESS OF ASPHALTENE DISPERSANT ADDITIVES FOR INHIBITING OR PREVENTING ASPHALTENE PRECIPITATION IN A HYDROCARBON-CONTAINING MATERIAL SUBJECTED TO ELEVATED TEMPERATURE AND PRESSURE CONDITIONS - Disclosed herein is a method for determining the effectiveness of one or more asphaltene dispersant additives for inhibiting or preventing asphaltene precipitation in a hydrocarbon-containing material subjected to elevated temperature and pressure conditions. | 05-15-2014 |
20140137639 | METHODS AND COMPOSITIONS FOR IMPROVED ION-EXCHANGE CHROMATOGRAPHY - The invention generally relates to ion-exchange chromatography. More particularly, the invention relates to compositions and methods that can substantially improve analytical sensitivity and/or selectivity of ion-exchange chromatography as well its efficiency and quality as a purification or preparation tool. | 05-22-2014 |
20140157877 | Downhole Determination Of Asphaltene Content - A system and method for determining the asphaltene content of a downhole oil sample are provided. In one example, the method includes obtaining a hydrocarbon sample from a hydrocarbon formation of a reservoir at a given depth using a downhole tool. A liquid phase of the hydrocarbon sample is isolated within the downhole tool and the liquid phase is subjected to downhole analysis within the downhole tool to create a chromatography sample. The downhole analysis is based at least partially on size exclusion chromatography. A first property of the chromatography sample is measured to obtain a measured value, and a second property of the chromatography sample is estimated based on the measured value and known calibration curves. | 06-12-2014 |
20140174160 | MICROFLUIDIC DEVICE WITH DRIED BLOOD SPOTS (DBS) CARD INTERFACE - An apparatus for use in a chromatography system includes a first microfluidic substrate having a first fluidic channel. One end of the first fluidic channel terminates at a first fluidic port on a first side of the first microfluidic substrate and an opposite end of the first fluidic channel terminates at a second fluidic port on a second side of the first microfluidic substrate. A second microfluidic substrate has a second fluidic channel. One end of the second fluidic channel terminates at a first fluidic port on a first side of the second microfluidic substrate. The first side of the second microfluidic substrate abuts the second side of the first microfluidic substrate such that the fluidic port of the second microfluidic substrate aligns with one of the fluidic ports of the first microfluidic substrate and the alignment produces a fluidic path comprised of the first and second fluidic channels. | 06-26-2014 |
20140190243 | FLUORESCENCE SPECTROPHOTOMETER - A fluorescence spectrophotometer according to the present invention includes: a light source | 07-10-2014 |
20140208836 | ANALYSIS OF DRIED BLOOD SPOT SAMPLES IN A MICROFLUIDIC SYSTEM WITH DILUTION OF EXTRACTED SAMPLES - An apparatus for use in a chromatography system includes a microfluidic substrate having a fluidic channel configured as an analytical chromatographic column and a fluidic port on one side of the microfluidic substrate. The fluidic port opens at a head end of the analytical chromatographic column. A dried blood spot (DBS) collection device holds one or more dried biological samples. The DBS collection device is directly coupled to the microfluidic substrate whereby one of the biological samples is placed into fluidic communication with the fluidic channel of the microfluidic substrate and an extraction of that biological sample flows toward the head end of the analytical chromatographic column. A diluent source fluidically coupled to the fluidic port supplies a solvent to the head end of the analytical column to dilute the extracted biological sample before the biological sample flows into the analytical chromatographic column. | 07-31-2014 |
20140230528 | TURBULENT FLOW MIXING DEVICE FOR USE IN A CHROMATOGRAPHY SYSTEM - A mixing device for use in a chromatography system, the device includes an exterior housing having a first end and a second end and a hydraulic flow connector at the first end of the exterior housing. A cartridge including a chamber is enclosed within the exterior housing. The chamber has at least one wall defining an interior volume having a shape, wherein the shape of the interior volume creates a turbulent flow condition to mix at least two fluids and provide flow through the cartridge during operation of the chromatography system. The chamber also retains the sample, thereby ensuring that the sample is focused in the chamber such that a more narrow bolus of sample enters the chromatography column. | 08-21-2014 |
20140245818 | ANALYSIS METHOD FOR DYE FOR ORGANIC SOLAR CELL AND PURIFICATION METHOD THEREFOR - This analysis method includes: subjecting a sample solution of a dye-containing sample in an organic solvent to normal-phase liquid chromatography to separate the sample solution and detect separated components. The normal-phase liquid chromatography involves (B1) using a separation column filled with a column packing material which is prepared by modifying a base material with a polar modifying group, and (B2) using as an eluent a polar organic solvent containing an acid. | 09-04-2014 |
20140311228 | LIQUID CHROMATOGRAPH APPARATUS AND LIQUID CHROMATOGRAPH ANALYSIS METHOD - An analysis method is achieved in which pressure variation resulting from sample injection or passage switching by an autosampler does not exert an influence on the control of a liquid transfer pump. The liquid chromatograph analysis method comprises the steps of: transferring two or more types of eluents while changing a mixing ratio between the eluents; adjusting an amount of the transferred liquid within a predetermined time in a passage for the eluent transferred; injecting a sample in the passage; supplying to a separation column the eluent into which the sample is injected; separating a target component in the sample; and detecting the target component thus separated. In this method, control is exercised so as to synchronize a liquid transfer cycle of the eluent with the sample injecting operation and to implement the sample injecting operation at a timing rather than the pressure obtaining time. | 10-23-2014 |
20140326055 | CHROMATOGRAPHY OF METAL COMPLEXES - A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided. | 11-06-2014 |
20140338431 | Methods for Injecting Samples in Liquid Chromatography, Particularly in High Performance Liquid Chromatography - A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop. | 11-20-2014 |
20140345370 | DEVICES, SYSTEMS AND METHODS FOR ANALYZING FLUID STREAMS - Certain embodiments described herein are directed to systems and methods that can be used to analyze species in a fluid stream. In some configurations, a sorbent tube effective to directly sample aromatics and/or polyaromatics in a fluid stream is described. | 11-27-2014 |
20140345371 | Sample Injector For Liquid Chromatography, Particularly For High Performance Liquid Chromatography - A sample injector for liquid chromatography includes an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop. | 11-27-2014 |
20140373605 | Liquid Sampling Valve - A liquid sampling system includes a liquid sampling valve for transferring a liquid sample from a primary stream to a secondary stream. The liquid sampling valve includes a rotor having a movable shuttle that is in selective fluid communication with the primary stream or the secondary stream. The rotor shuttle passes through a discharge station prior to completion of the valve cycle to discharge contaminants prior to re-exposure to the primary stream. | 12-25-2014 |
20140373606 | MICROMACHINED FLOW CELL WITH FREESTANDING FLUIDIC TUBE - A micromachined flow cell ( | 12-25-2014 |
20150027207 | Measuring Multi-Analyte Samples Using an In-Line Flow Cell - Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can be routed to a sample container for future processing. The sample can comprise diluted blood and the analytes can comprise a component of hemoglobin, such as A1c, and the total amount of hemoglobin, of which the predetermined amount is metered. | 01-29-2015 |
20150059451 | PREVENTION OF PHASE SEPARATION UPON PROPORTIONING AND MIXING FLUIDS - A fluid supply system ( | 03-05-2015 |
20150121996 | Automated Sample Injection Apparatus, Multiport Valve, and Methods of Making and Using The Same - Automated sample injection apparatus, multiport valves, and chromatography systems containing an automated sample injection apparatus and/or a multiport valve are disclosed. Methods of making and using automated sample injection apparatus and multiport valves within chromatography systems are also disclosed. | 05-07-2015 |
20150128685 | SAMPLING DEVICE - The invention relates to a sampler for providing a sample for high-performance liquid chromatography, in which a volume of liquid to be taken up into a cylinder can be aspirated by means of a first drive and can be compressed to a high pressure level by means of a second drive independent of the first drive or can be decompressed from this level in a controlled manner. | 05-14-2015 |
20150316455 | SAMPLE DILUTION TO SPECIFIABLE DILUTION RATIO - A dilution apparatus ( | 11-05-2015 |
20150316515 | MATERIALS FOR HYDROPHILIC INTERACTION CHROMATOGRAPHY AND PROCESSES FOR PREPARATION AND USE THEREOF FOR ANALYSIS OF GLYCOPROTEINS AND GLYCOPEPTIDES - The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra/inter-particle diffusion distances. | 11-05-2015 |
20150330887 | APPARATUS AND METHOD FOR MICROPARTICLE SEPARATION BASED ON MICROFLUIDIC CHROMATOGRAPHY USING SURFACE ACOUSTIC WAVE - The present invention related to an apparatus for separating micro-nano scale particles based on microfluidic chromatography using surface acoustic waves, comprising: a piezoelectric substrate; a pair of transducers, which are patterned on the piezoelectric substrate and generate surface acoustic waves when electric energy is applied to the piezoelectric substrate; a microfluidic chip, which is mounted on the piezoelectric substrate and include a microfluidic channel disposed between the pair of transducers, wherein a fluid including micro-nano scale particles flows in the microfluidic channel; and a detection unit, which detects micro-nano scale particles separated by the surface acoustic waves while the micro-nano scale particles pass through the microfluidic channel, wherein forces of the surface acoustic waves generated by the pair of transducers are formed in a direction opposite to a fluid flow to generate flow resistance to the micro-nano scale particles which flows in the microfluidic channel. | 11-19-2015 |
20150330954 | SUPERCRITICAL FLUID PROCESSING DEVICE - A supercritical fluid chromatograph includes a supercritical flow path, a mobile phase supply section for supplying a mobile phase containing liquid carbon dioxide, a sample introduction section, a sample separation section, a detector, and a pressure control valve. A valve post-stage flow path is connected to a fluid outlet of the pressure control valve, and the inside of the valve post-stage flow path is maintained by pressure maintaining means at a pressure by which a mobile phase from the fluid outlet of the pressure control valve is not vaporized. | 11-19-2015 |
20150346166 | SAMPLE CONCENTRATION DEVICE - A controller for controlling the operations of an autosampler, a sample push unit, and a make-up unit includes a pump stop timing setting unit for setting a first timing T | 12-03-2015 |
20150355149 | METHOD AND DEVICE FOR CARRYING OUT THIN-LAYER CHROMATOGRAPHY - The invention relates to a method for carrying out thin-layer chromatography in which a liquid sample is applied to a separating layer ( | 12-10-2015 |
20160025689 | SAMPLE INJECTOR WITH METERING DEVICE BALANCING PRESSURE DIFFERENCES IN AN INTERMEDIATE VALVE STATE - A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state. | 01-28-2016 |
20160025692 | Analysis System - An analysis system is provided with: a storage unit that stores first information associating mass spectrometry result information with an analysis condition concerning ion mobility separation; and a control unit that determines, as a first analysis condition for an ion to be measured, the analysis condition associated with the mass spectrometry result information of the first information corresponding to the mass spectrometry result information of the ion to be measured. | 01-28-2016 |
20160054274 | INJECTOR SAMPLE DILUTION FOR A LIQUID CHROMATOGRAPHY SYSTEM - Described are a method and a system for diluting a sample at a location of injection in a liquid chromatography system. The method includes loading a sample into a first fluid channel, separating a flow of a mobile phase into a first flow in the first fluid channel and a second flow in a second fluid channel, and combining the sample that is displaced from the first fluid channel and the mobile phase exiting the second fluid channel at the location of injection into the system flow to thereby generate a diluted sample in the system flow. The dilution ratio of the diluted sample is responsive to the flow rates of the first and second flows. Advantageously, the flow rates can be changed by changing the flow restriction of one of the fluid channels. Thus providing the proper flow restriction enables a user to obtain a desired dilution ratio. | 02-25-2016 |
20160061787 | AUTOMATED ANALYSIS SYSTEMS - The disclosure relates to systems and methods for performing high performance liquid chromatography (HPLC) on a liquid sample. The methods include automatically, using a computer, controlling a liquid sample including a plurality of components to flow through a first flow path in a system for HPLC. Flowing through the first flow path includes flowing the liquid sample through a capture column. The capture column is capable of trapping at least some of the components of the liquid sample. The method includes automatically, using the computer, controlling a solvent to flow through a second flow path in the system for HPLC. Flowing through the second flow path includes flowing the solvent through the capture column to elute the trapped components from the capture column; flowing the solvent and eluted components through an analysis column capable of separating the eluted components; and flowing the separated components to a detector. | 03-03-2016 |
20160069844 | CONTROLLABLE INJECTOR SAMPLE DILUTION FOR A LIQUID CHROMATOGRAPHY SYSTEM - Described are a method and a system for injecting a sample into a flow of a liquid chromatography system. The method includes combining a flow of a sample and a flow of a mobile phase to create a diluted sample in the system flow. The volumetric flow rate of the sample is controlled to be at a value that yields a desired dilution ratio for the diluted sample. The particular value at which the volumetric flow rate is maintained can be determined from the desired value of the dilution ratio and the volumetric flow rate of the mobile phase. System embodiments include a syringe that can be used to provide a sample solution at a controllable volumetric flow rate for combination with a high pressure mobile phase. | 03-10-2016 |
20160077061 | SAMPLING SYSTEMS AND METHODS OF USING THE SAME - A sampling system comprising an external sampling assembly in fluidic communication with a process sample manager is provided herein. The sampling system can automatically acquire sample from one or more sources of sample to prepare sample for injection into a column or detector. The external sampling assembly has an external sampling valve connected to an external pump and is in fluidic communication with a process sample manager. The external sampling valve has a first configuration and a second configuration useful in three steps of drawing, loading and discharging sample. Two selection valves can be connected to a plurality of external sampling valves for sequential sampling of multiple sources of sample. Sample can also be diluted in the process sample manager and then combined in a solvent composition stream for injection into the column or the detector. | 03-17-2016 |
20160097753 | Dissolution of hydrophobic API, including avermectins with or without other API such as pyrantel, from a complicated matrix dosage form - This disclosure describes the results of the studies conducted to develop a dissolution method to monitor release profiles of hydrophobic active pharmaceutical ingredients such as ivermectin with or without pyrantel pamoate from a drug product made of complex matrix that includes, but is not limited to beef, tallow, corn cob and soy protein. | 04-07-2016 |
20160116446 | ANALYSIS METHOD FOR ORGANIC SUBSTANCES IN SOLUTION TO BE EXAMINED - An analysis method is provided, by which it is determined whether or not a solution to be-examined contains an organic substance in an amount on the order of 20 mass ppb or less. The analysis method for organic substances in a solution to be examined includes the following steps: a sampling step in which 500 ml or less of a sample solution is taken front a solution to be examined; an adsorption step in which the sample solution is passed through activated carbon 8 so that the organic substance is adsorbed on the activated carbon; an extraction step in which the organic substance is extracted into a hydrophobic solvent; a specimen preparation step in which, a specimen solution is prepared by using the hydrophobic solvent into which the organic substance has been extracted; and an analysis step in which an analysis is performed to determine whether or not the organic substance in an amount of 20 mass ppb or less is contained in the solution to be examined. The activated carbon 8 has a specific surface area of 800 m | 04-28-2016 |
20160137530 | ION EXCHANGE BASED VOLATILE COMPONENT REMOVAL DEVICE FOR ION CHROMATOGRAPHY - A method, device, and system for removing a volatile component from a liquid solution for a chromatographic separation are described. The method includes the flowing of a liquid solution through a first chamber of the device. A volatile component in the liquid solution is transported across a first ion exchange barrier from the first chamber to a second chamber. The first ion exchange barrier has a first charge. The second chamber includes an ion exchange packing having a second charge that is an opposite polarity to the first charge. The volatile component reacts with the ion exchange packing to create a charged component in the second chamber. The charged component having a third charge that is a same polarity to the first charge. The ion exchange packing is regenerated by electrolytically generating a hydronium or a hydroxide. | 05-19-2016 |
20160145316 | FREEZE-DRIED PREPARATION CONTAINING HIGH-PURITY PTH AND METHOD FOR PRODUCING SAME - [Problem] Provided is a freeze-dried preparation containing high-purity PTH peptide and a method for the production thereof. Also provided is a test method for PTH analogs to confirm the purity of a freeze-dried preparation containing PTH peptide, and the like. | 05-26-2016 |
20160153941 | LIQUID CHROMATOGRAPHY APPARATUS FOR FAST MEASURING | 06-02-2016 |
20160153942 | GRADIENT LIQUID FEED DEVICE FOR SAMPLE ANALYZER | 06-02-2016 |
20160169858 | LOW VOLUME IN-LINE FILTRATION METHOD FOR EVALUATION OF ASPHALTENES FOR HYDROCARBON-CONTAINING FEEDSTOCK | 06-16-2016 |
20160195500 | CHROMATOGRAPHIC DEVICE AND METHOD | 07-07-2016 |
20160377580 | SAMPLER FOR LIQUID CHROMATOGRAPHY - A sampler for liquid chromatography is described. The sampler includes an injection valve and a sample loop. The injection valve includes one waste port, two sample loop ports, and two high-pressure ports. The sample loop port includes a first loop part and a second loop part. The injection valve can be configured to have LOAD position and INJECT position. The injection valve can also be configured to have one or more additional positions such as a FULL PURGE position, a PUMP PURGE position, and a NEGATIVE PRESSURE position. | 12-29-2016 |
20170234839 | PREPARATIVE SEPARATION LIQUID CHROMATOGRAPH SYSTEM AND PREPARATIVE SEPARATION CONDITION SEARCHING METHOD | 08-17-2017 |
20170234841 | OPEN PORT SAMPLING INTERFACE | 08-17-2017 |