| Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Patent applications |
| Patent application number | Title | Published |
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| 20120129947 | AMINO-ALCOHOL ANALOGUES AND USES THEREOF - This invention relates to amino-alcohol analogues and uses thereof in the treatment of diseases and disorders such as cancer, neurodegenerative and metabolic diseases and genetic storage diseases. | 05-24-2012 |
| 20120114574 | Compositions for nail and skin treatment - Novel topical compositions for the treatment of nail and skin afflictions comprising at least one active agent, at least one volatile solvent, at least one film-forming ingredient and at least one phospholipid, processes for their preparation and methods of treatment of nail and skin afflictions. Following application of the compositions and evaporation of volatile solvents, the composition produces a film, which has web-like structures containing the active agent(s). | 05-10-2012 |
| 20120100206 | TARGETED LIPOSOMES COMPRISING N-CONTAINING BISPHOSPHONATES AND USES THEREOF - The present is based on the finding that folate targeted liposomal alendronate (FT-AL-L) was significantly more potent against two tested cancer cell lines than the free alendronate (AL) or the non-targeted liposomal alendronate (AL-L), as observed by the increased cytotoxicity of the folate targeted liposomal alendronate. Thus, the present disclosure provides targeted liposomes comprising a membrane and an intraliposomal core, the membrane comprising at least one liposome forming lipid and a targeting moiety, such as folate, exposed at the membrane's outer surface; and the intraliposomal core comprising encapsulated therein least one N-containing bisphosphonate. Also provided by the present disclosure are methods of use of the targeted liposomes such as for the treatment of a disease or disorder. | 04-26-2012 |
| 20120092446 | METHOD AND SYSTEM FOR PRODUCING A VIDEO SYNOPSIS - A computer-implemented method and system transforms a first sequence of video frames of a first dynamic scene to a second sequence of at least two video frames depicting a second dynamic scene. A subset of video frames in the first sequence is obtained that show movement of at least one object having a plurality of pixels located at respective x, y coordinates and portions from the subset are selected that show non-spatially overlapping appearances of the at least one object in the first dynamic scene. The portions are copied from at least three different input frames to at least two successive frames of the second sequence without changing the respective x, y coordinates of the pixels in the object and such that at least one of the frames of the second sequence contains at least two portions that appear at different frames in the first sequence. | 04-19-2012 |
| 20120078163 | METHOD OF GENERATING CONNECTIVE TISSUE - A method of generating bone or connective tissue in a subject in need thereof, the method comprising: (a) implanting a scaffold in a damaged region of the subject, the scaffold comprising a tissue growth promoting agent; and (b) enhancing uptake of the tissue growth promoting agent into cells located on the scaffold, wherein the enhancing is effected by induced poration of the cells thereby generating bone or connective tissue in the subject. Kits for generating bone or connective tissue are also provided. | 03-29-2012 |
| 20120070469 | BETA-CASEIN ASSEMBLIES FOR MUCOSAL DELIVERY OF THERAPEUTIC BIOACTIVE AGENTS - Nanoparticulate assemblies of isolated β-casein are useful for encapsulation of bioactive therapeutic substances, particularly therapeutic agents with poor bioavailability. The nanoparticulate assemblies can be freeze-dried and re-suspended prior to administration. | 03-22-2012 |
| 20120056341 | SILICA NANOCAPSULES FROM NANO-EMULSIONS OBTAINED BY PHASE INVERSION - Silica nanocapsules are prepared from a nanoemulsions obtained by a phase inversion method. | 03-08-2012 |
| 20120035140 | CARBAMOYLPHOSPHONATES AS INHIBITORS AND USES THEREOF - The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP. | 02-09-2012 |
| 20120022005 | Synthetic Dragline Spider Silk-Like Proteins - The present application relates to isolated amino acid sequence comprising multiple repeats of a semi-synthetic spider silk protein domain, or any functional homolog, variant, derivative, fragment or mutant thereof. The amino acid sequence of the invention further comprises an N-terminal region and a C-terminal region. The invention further provides a nucleic acid encoding the amino acid sequence of the invention, an expression vector comprising said nucleic acid, a host cell transformed with said expression vector, a recombinant spider silk protein thus produced and a fiber composed of the recombinant spider silk protein. The invention further encompasses a composition comprising as an active ingredient said amino acid sequence or any said recombinant protein or fiber comprising the same. Lastly, the invention relates to an article comprising at least one fiber composed of said recombinant spider silk protein. | 01-26-2012 |
| 20120009148 | METHODS OF PREDICTING RESPONSIVENESS TO INTERFERON TREATMENT AND TREATING HEPATITIS C INFECTION - Provided are methods of predicting responsiveness of a subject to interferon treatment, comprising comparing a level of expression in a cell of the subject of at least one gene selected from the group consisting KIR3DL3, KIR3DL2, KIR3DL1, KIR2DL1, KIR2DL2, KIR2DL3, KLRG1, KIR3DS1, CD160, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G and IFI27 to a reference expression data of the at least one gene obtained from at least one interferon responder subject and/or at least one interferon non-responder subject. Also provided are methods and pharmaceutical compositions for treating a subject in need of interferon treatment. | 01-12-2012 |
| 20110293879 | ASSEMBLIES COMPRISING BLOCK CO-POLYMER FILMS AND NANORODS - Provided is an assembly including a block co-polymer film and a plurality of nano-rods; where the plurality of nano-rods are oriented at the surface of the block co-polymer film, substantially perpendicular to at least one interface between block co-polymer domains. Further provided are methods of assembly formation and devices including such assemblies. | 12-01-2011 |
| 20110287974 | METHODS AND KITS FOR ASCERTAINING BIOSAFETY OF AN AGENT - A method of ascertaining the bio-safety of an agent is disclosed. The method comprises:
| 11-24-2011 |
| 20110287071 | METHODS OF GENERATING TISSUE USING DEVITALIZED, ACELLULAR SCAFFOLD MATRICES DERIVED FROM MICRO-ORGANS - A composition of matter is provided comprising a devitalized, acellular tissue-derived scaffold seeded with differentiated cells, particularly pancreatic islet cells, wherein the cells can maintain cell-specific function or structure in culture on the scaffold. Methods of generating same and uses thereof are also provided. | 11-24-2011 |
| 20110283945 | SEX-PEPTIDES RESISTANT TO PROTEOLYTIC DEGRADATION AND THEIR USE IN BIOLOGICAL CONTROL OF INSECTS - An isolated nucleic acid molecule comprising, or consisting of, a polynucleotide sequence encoding an oligopeptide capable of inducing post-mating depression of receptivity to mating in female insects, wherein said oligopeptide is resistant to proteolytic degradation, is provided for expression in sterile transgenic male insects useful in the control of insect populations. | 11-24-2011 |
| 20110281921 | NOVEL ANTI-BIOFILM AGENTS - Novel agents exhibiting anti-biofilm formation activity while being non-cytotoxic are provided, as well as methods of using the same, either per se or conjugated to a polymer, for preventing and/or reducing the formation of microbial biofilms and/or for disrupting microbial biofilms. The novel agents described herein include thiazolidine-2,4-diones (TZDs), pyrrolidine-2,5-diones (PYDs), imidazolidine-2,4-diones or oxazolidine-2,4-diones, substituted by an alkyl having 7-20 carbon atoms in its backbone chain. | 11-17-2011 |
| 20110269842 | COMPOSITIONS COMPRISING CB RECEPTOR AGONISTS, USES THEREOF AND METHODS FOR THEIR PREPARATION - Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided. | 11-03-2011 |
| 20110188043 | METHOD AND APPARATUS FOR MONITORING PROCESSES IN LIVING CELLS - The invention provides a method and apparatus for monitoring processes in living cells by measuring optical reflectivity by Surface Plasmon Resonance at the surface and/or inside living cells attached to a thin metal film ( | 08-04-2011 |
| 20110183128 | CORE-SHELL METALLIC NANOPARTICLES, METHODS OF PRODUCTION THEREOF, AND INK COMPOSITIONS CONTAINING SAME - Provided is a composition including a plurality of multi-metallic nanoparticles each consisting essentially of a core including at least one first metal (Me1) and a continuous shell including atoms of at least one second metal (Me2). Optionally, the continuous shell of Me2 atoms protects the Me1 atoms from oxidation at all temperatures less than 150° C. | 07-28-2011 |
| 20110177606 | DETECTION OF TRINITROTOLUENE - An ultrasensitive method for detecting analytes in a sample is provided. The method involves the use of a matrix of nanoparticles which are associated with recognition groups capable of undergoing interaction with the analyte. | 07-21-2011 |
| 20110155587 | SYSTEM AND METHOD FOR DETECTING A SUBSTANCE IN LIQUID - A system for analyzing a liquid is provided. The system comprises:
| 06-30-2011 |
| 20110126317 | PLANT VIRAL EXPRESSION VECTORS AND USE OF SAME FOR GENERATING GENOTYPIC VARIATIONS IN PLANT GENOMES - A method of generating genotypic variation in a genome of a plant is disclosed. The method comprising introducing into the plant at least one viral expression vector encoding at least one chimeric nuclease which comprises a DNA binding domain, a nuclease and a localization signal to a DNA-containing organelle, wherein the DNA binding domain mediates specific targeting of the nuclease to the genome of the plant, thereby generating genotypic variation in the genome of the plant. | 05-26-2011 |
| 20110111010 | Method and Composition for Burned Skin - The present invention is directed to the use of an agent selected from ethyl alcohol, isopropyl alcohol or a mixture thereof and a topically acceptable polymeric carrier in the preparation of a composition for the treatment of burns. | 05-12-2011 |
| 20110094582 | PHOTOCHEMICAL ELECTRODE, CONSTRUCTION AND USES THEREOF - Provided is an electrode including a conductive surface connected to a matrix; the matrix including a plurality of semiconductor nanoparticles and noble metal nanoparticles, substantially each of which is connected to another nanoparticle of the plurality of nanoparticles by at least one matrix connecting group and at least a portion of the plurality of nanoparticles of the matrix is each connected to the conductive surface by at least one surface connecting group. Further provided are photovoltaic cells and devices including electrode of the invention. | 04-28-2011 |
| 20110081286 | SCRUBBER FOR REMOVING HEAVY METALS FROM GASES - A wet scrubber, a liquor for a wet scrubber, and a power-plant comprising a wet scrubber are described. | 04-07-2011 |
| 20110064716 | MATERIALS AND METHODS FOR TREATING OR PREVENTING ORGANOPHOSPHATE EXPOSURE ASSOCIATED DAMAGE - A method of treating or preventing organophosphate exposure associated damage in a subject in need thereof is provided. The method comprising providing the subject with a therapeutically effective amount of AChE-R to thereby treat the organophosphate exposure associated damage in the subject. | 03-17-2011 |
| 20110046222 | FATTY ACID AMIDES AND USES THEREOF - Provided are fatty acid amides of amino acids, uses thereof and pharmaceutical compositions including them. | 02-24-2011 |
| 20100317588 | COMPOSITIONS COMPRISING FIBROUS POLYPEPTIDES AND POLYSACCHARIDES - Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed. | 12-16-2010 |
| 20100298420 | Compositions and Methods for Intracellular Delivery - The invention relates to intracellular delivery of alcoholic lipid compositions for medical, cosmetic, research, diagnostic, veterinary, agriculture or pharmaceutical use containing phospholipid(s), ethanol (or other C2-C4 such volatile alcohols), water, at least one active molecule, optional addition of glycols and/or other additions for delivery to cells of an entrapped, attached, adsorbed, and/or complexed molecule(s). | 11-25-2010 |
| 20100280124 | ACYL-UREA DERIVATIVES AND USES THEREOF - Novel acyl-urea containing compounds, processes of preparing same, compositions containing same and uses thereof in the treatment of neurological diseases and disorders such as epilepsy, neuropathic pain, bipolar disorder, status epilepticus, chemically-induced convulsions and/or seizure disorders, febrile convulsions conditions, metabolic disturbances and a sustenance withdrawal conditions, are provided. Also provided are uses of these and other acyl-urea containing compounds in the treatment of neurological diseases and disorders. | 11-04-2010 |
| 20100210718 | SYNERGISTIC ANTI-OXIDANT TREATMENT FOR LIPOTOXICITY AND OTHER METABOLICALLY RELATED PHENOMENA - A method for ameliorating, reducing, and/or preventing lipotoxicity-induced metabolic dysfunction in at least one cell is disclosed, said method comprising a step of contacting said at least one cell with a therapeutically effective amount of a synergistic anti-lipotoxicity cocktail, said cocktail comprising N-acetylcysteine, ascorbic acid, and resveratrol. Also disclosed is a method for treating at least one lipotoxicity-related metabolic disorder chosen from the group comprising (a) metabolic syndrome; (b) non-alcoholic steatohepatitis; (c) obesity; and (d) coronary heart disease, said method comprising the step of administering to a patient a therapeutically effective amount of an anti-lipotoxicity cocktail, said cocktail comprising N-acetylcysteine, ascorbic acid, and resveratrol. Finally, a composition for treating the effects of lipotoxicity, containing a synergistic combination of N-acetylcysteine, ascorbic acid, and resveratrol is disclosed. | 08-19-2010 |
| 20100195781 | NEUTRON BEAM RADIATION APPARATUS - A liquid lithium jet nozzle comprising: an inlet through which liquid lithium flows into the nozzle; an inlet flow channel that receives liquid lithium that flows into the nozzle via the inlet and shapes the flowing liquid lithium to flow in a thin film; and a flow region that receives flowing liquid lithium shaped by the flow channel and in which the liquid lithium flows with at least one large surface of the film exposed. | 08-05-2010 |
| 20100183222 | System and method for edge-enhancement of digital images using wavelets - Systems, methods, and techniques are provided for performing any one or more of edge-preserving image sharpening, edge-preserving image smoothing, edge-preserving image dynamic range compression, and edge-aware data interpolation on digital images, wherein a pixel prediction module is adapted for coupling to a memory storing pixel data representative of a digital image and extracts from the image predicted pixel values using robust smoothing. The predicted pixels are stored in a memory and respective detail values equal to the difference between respective original and predicted values are computed. A pixel update module computes approximation values by averaging the respective detail values with original pixel values using robust smoothing, and stores the approximation values for subsequent rendering. The prediction and update modules run recursively and a manipulation module increases or decreases the detail values and the approximation values depending on their magnitude and depending on the kind of edge enhancement required. | 07-22-2010 |
| 20100170958 | HURRICANE MITIGATION BY COMBINED SEEDING WITH CONDENSATION AND FREEZING NUCLEI - The invention provides method for treating a tropical cyclone, a tropical storm or a tropical depression. The method includes reducing unloading of cloud parcel water in the tropical cyclone, tropical storm or tropical depression. In a preferred embodiment, unloading of cloud parcel water is accomplished by seeding with cloud condensation nuclei, such as sub-micron ammonium sulfate particles. The treatment is preferably applied to the lower parts of peripheral clouds in the tropical cyclone, tropical storm or tropical depression below the 0 C isotherm level. | 07-08-2010 |
| 20100152254 | ALPHA-HALO- AND ALPHA-ALKYL-CYCLOPROPYLCARBOXY COMPOUNDS AND USES THEREOF - Novel Alpha-halo- and Alpha-alkyl-cyclopropylcarboxy compounds, and uses of these and related compounds in the treatment of a variety of neurological diseases and disorders, and particularly epilepsy, are provided. | 06-17-2010 |
| 20100136012 | VARIANTS OF VEGFR AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF PREGNANCY ASSOCIATED MEDICAL CONDITIONS - An isolated polypeptide variant of VEGFR comprising an amino acid sequence at least 70% homologous to SEQ ID NO: 4 and an isolated polynucleotide encoding same are disclosed. A polynucleotide comprising a nucleic acid sequence capable of specifically hybridizing to the isolated polynucleotide and an isolated antibody comprising an antigen recognition domain which specifically binds the isolated polypeptide are also disclosed. Pharmaceutical compositions, methods of diagnosing and treating comprising same are also disclosed. | 06-03-2010 |
| 20100099756 | USES OF INCENSOLE, INCENSOLE ACETATE AND DERIVATIVES THEREOF - The described subject matter relates to the use of incensole, incensole acetate, and derivatives thereof, for the treatment, prevention or amelioration of diseases or conditions, including inflammatory-associated conditions; a disease or condition where neuroprotection is required; and a disease or condition selected from depression, anxiety, obsessive compulsive behaviors, deterioration in cognitive function, and deterioration in neurobehavioral function. Pharmaceutical compositions and method of treatment, prevention or amelioration of the above-mentioned diseases or conditions are also provided. | 04-22-2010 |
| 20100067847 | TUNABLE OPTOFLUIDIC DEVICE AND METHOD OF ITS FABRICATION - An integrated structure and method of its fabrication are presented. The integrated structure comprises at least one waveguide; at least one fluid chamber; and an electrode assembly. The fluid chamber is associated with said at least one waveguide and configured and operable to selectively allow one or more droplets of said fluid from the fluid chamber to access at least a portion of the waveguide thereby selectively creating one or more fluid-waveguide interfaces and affecting the effective refractive index of the waveguide and light coupling at said one or more interface. The electrode assembly is configured and operable to induce an electric field within said at least one fluid chamber to affect the fluid-waveguide interface, thereby affecting light propagation in said waveguide and accordingly affecting optical properties of the integrated structure. | 03-18-2010 |
| 20090306959 | PERSONAL TEXT ASSISTANT - A method and system of generating personalized annotated text of a core-text, the method and system directed for acquiring a personal data comprising data indicative of the reader's proficiency level for understanding text; and providing at least a gloss to accompany the requested text based on core-text and the reader's proficiency level. | 12-10-2009 |
