| Wisconsin Alumni Research Foundation Patent applications |
| Patent application number | Title | Published |
|---|
| 20120135889 | METHODS AND COMPOSITIONS FOR IMPROVED FERTILIZATION AND EMBRYONIC SURVIVAL - Single nucleotide polymorphic site at position 11646 of the bovine FGF2 gene is associated with improved fertilization rate and/or improved embryo survival rate, as well as improved milk production. Also disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods. | 05-31-2012 |
| 20120134926 | CHARGE-DYNAMIC POLYMERS AND DELIVERY OF ANIONIC COMPOUNDS - The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided. | 05-31-2012 |
| 20120129194 | Visible Detection of Microorganisms - Methods of detecting very low levels of targets, such as cells, are provided. In some embodiments, for example, the methods can detect bacteria present in a sample at concentrations less than 25 cells/mL. The method involves detecting nanoparticle aggregation in the absence of the target. | 05-24-2012 |
| 20120116007 | PATTERNABLE POLYMER BLOCK BRUSH LAYERS - Provided are novel polymer brushes that may be used in underlying buffer or imaging layers for block copolymer lithography. The novel polymer brushes include X-A-b-B and X-A-b-C block copolymer brushes, with X an anchoring group, the A block a lithographically sensitive polymer, and the C block a random copolymer. According to various embodiments; polymer block brushes for neutral and preferential layers are provided; the neutral layers non-preferential to the overlying block copolymer and the preferential layers preferential to a block of the overlying block copolymer. Also provided are novel methods of patterning polymer block brush layers as well as polymer block brush buffer and imaging layers that are directly patternable by e-beam, deep UV, extreme UV, X-ray or other lithographic methods. | 05-10-2012 |
| 20120106377 | METHOD AND APPARATUS FOR PROVIDING A MEASUREMENT OF PERFORMANCE FOR A NETWORK - Performance for a network is measured by sending multi-objective probes on a path, receiving at least one of the multi-objective probes for the path, and determining performance measurements for at least two parameters of the path determined from the at least one of the multi-objective probes. Separate algorithms are simultaneously executed to measure the at least two parameters of the path determined from the at least one of the multi-objective probes. | 05-03-2012 |
| 20120094946 | GLYCOSYLATED CHLORAMBUCIL ANALOGS AND USES THEREOF - A library of glycosylated chlorambucil analogs which are useful as anti-tumor and/or anti-metastatic agents is disclosed. The glycosylated chlorambucil analogs have the general formula | 04-19-2012 |
| 20120088276 | METHOD FOR USING REF PROTEIN AS A TARGETED RECA-DEPENDENT NUCLEASE - Kits and a method for cleaving double-stranded DNA using Ref and RecA protein and variants thereof at a site having a DNA sequence homologous to the sequence on a single-stranded DNA targeting fragment are disclosed. | 04-12-2012 |
| 20120083614 | (20R,25S)-2-Methylene-19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 in Crystalline Form - A method of purifying (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D | 04-05-2012 |
| 20120077738 | COMPOSITIONS AND METHODS FOR PREDICTING HCV SUSCEPTIBILITY TO ANTIVIRAL AGENTS - Methods for determining the susceptibility of a hepatitis C virus (HCV) in a patient to anti-viral agents, particularly cyclophilin inhibitors such as cyclosporine A, are disclosed. The methods include determining the amino acid sequence within a region of the HCV NS5A protein and comparing the viral amino acid sequence to that of a reference strain, wherein the existence of at least one variant/mutation in the viral genome is indicative that the virus is more or less susceptible to anti-viral agents. Also disclosed are isolated polynucleotide molecules, replicons, and kits that can be used to assay the susceptibility of hepatitis HCV in a patient to anti-viral agents. | 03-29-2012 |
| 20120071562 | 2alpha-Methyl-19-Nor-(20S)-1alpha-Hydroxy-Bishomopregnacalciferol and Its Uses - This invention discloses 2α-methyl-19-nor-(20S)-vitamin D analogs, and specifically 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity. | 03-22-2012 |
| 20120065150 | Neuroprotective effects of 2DG in Traumatic Brain Injury - This invention provides methods for reducing the extent and progression of traumatic brain injury and its deleterious sequellae specifically cognitive decline, post-traumatic epilepsy, post-traumatic stress disorder, and other adverse consequences depending on the progression of the initial injury, comprising administering to a TBI victim in need thereof a therapeutically-effective amount of an antiglycolytic compound, particularly 2-deoxyglucose (2-DG) or glycolysis-inhibiting analogs thereof. The invention also provides pharmaceutical compositions of 2-DG or glycolysis-inhibiting analogs thereof for use in the methods of the invention. | 03-15-2012 |
| 20120064591 | RECOMBINANT YEAST WITH IMPROVED ETHANOL TOLERANCE AND RELATED METHODS OF USE - The present invention provides isolated Elo1 and Mig3 nucleic acid sequences capable of conferring increased ethanol tolerance on recombinant yeast and methods of using same in biofuel production, particularly ethanol production. Methods of bioengineering yeast using the Elo1 and, or, Mig3 nucleic acid sequences are also provided. | 03-15-2012 |
| 20120064088 | METHODS OF TREATING ANEURYSM - The present invention is directed to a method for treating aneurysms in vascular tissue. The method includes administering a bisphosphonate compound to a subject in an amount which is effective against the formation or progression of aneurysm, or which is effective to induce regression of an established aneurysm. In alternative methods, an anti-RANKL neutralizing antibody is administered to the subject to achieve analogous anti-aneurysm effect. The methods of particular advantage in the treatment of subjects having an abdominal aortic aneurysm, a relatively common, and life-threatening, condition. | 03-15-2012 |
| 20120040860 | Methods for Determining Protein Binding Specificity Using Peptide Libraries - A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD | 02-16-2012 |
| 20120039350 | HIGH POWER, HIGH EFFICIENCY QUANTUM CASCADE LASERS WITH REDUCED ELECTRON LEAKAGE - Semiconductor structures and laser devices including the semiconductor structures are provided. The semiconductor structures have a quantum cascade laser (QCL) structure including an electron injector, an active region, and an electron extractor. The active region of the semiconductor structures includes a configuration of quantum wells and barriers that virtually suppresses electron leakage, thereby providing laser devices including such structures with superior electro-optical characteristics. | 02-16-2012 |
| 20120022230 | IONIZABLE ISOTOPIC LABELING REAGENTS FOR RELATIVE QUANTIFICATION BY MASS SPECTROMETRY - Relative quantification of metabolites by Electrospray Ionization Mass Spectrometry (ESI-MS) requiring a mechanism for simultaneous analysis of multiple analytes in two or more samples. Labeling reagents that are reactive to particular compound classes and differ only in their isotopic compositions facilitate relative quantification. Heavy and light isotopic forms of methylacetimidate were synthesized and used as labeling reagents for quantification of amine-containing molecules. Heavy and light isotopic forms of formaldehyde and cholamine were also synthesized and used independently as labeling reagents for quantification of amine-containing and carboxylic acid-containing molecules, such as found in biological samples. The labeled end-products are positively charged under normal acidic conditions involving conventional Liquid Chromatography Mass Spectrometry (LC/MS) applications. Labeled primary and secondary amine and carboxylic acid end-products generated higher signals concerning mass-spectra than pre-cursor molecules and improved sensitivity. Improved accuracy concerning relative quantification was demonstrated by mixing heavy and light labeled | 01-26-2012 |
| 20120010282 | Tautomycetin and Tautomycetin Analog Biosynthesis - The present invention relates to the biosynthetic gene cluster for tautomycetin (TTN) produces tautomycetin. Also provided are engineered micro-organisms for the production of TTN and analogs thereof, as well as methods of screening for compounds for activity. | 01-12-2012 |
| 20120003649 | METHODS FOR ASSESSING RISK OF ALZHEIMER'S DISEASE IN A PATIENT - Disclosed are methods for diagnosis or prognosis of Alzheimer's disease in a patient. The methods may include assessing whether a patient has Alzheimer's disease or assessing a patient's risk for developing Alzheimer's disease. The methods typically include determining, either directly or indirectly, whether the patient has mutations, such as single nucleotide polymorphisms, in a plurality of genes that encode gene products that function in steroid biosynthesis. | 01-05-2012 |
| 20110318385 | ENGINEERED BOTULINUM NEUROTOXIN C1 WITH SELECTIVE SUBSTRATE SPECIFICITY - An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed. The modified botulinum neurotoxin C1 light chain is capable of selectively cleaving syntaxin protein, but has substantially reduced or no activity against SNAP-25 as compared to wild type botulinum neurotoxin C1 light chain, and is thus useful as a research tool and in medical treatment. | 12-29-2011 |
| 20110306142 | IMMOBILIZATION OF DROPLETS OF LIQUID CRYSTALS ON SURFACES - Devices and methods for immobilizing micrometer sized liquid domains onto a chemically functionalized substrate surface are disclosed. A multifunctional polymer is adsorbed at the surface interface of the liquid microdomains, and the liquid microdomains are immobilized by covalent bonding or non-covalent forces such as electrostatic attraction between the adsorbed multifunctional polymer and the functionalized substrate surface. | 12-15-2011 |
| 20110306074 | GLYCOSYLTRANSFERASE REVERSIBILITY FOR SUGAR NUCLEOTIDE SYNTHESIS - The present invention generally relates to materials and methods for exploiting glycosyltransferase reversibility for nucleotide diphosphate (NDP) sugar synthesis. The present invention provides engineered glycosyltransferase enzymes characterized by improved reaction reversibility and expanded sugar donor specificity as compared to corresponding non-mutated glycosyltransferase enzymes. Such reagents provide advantageous routes to NDP sugars for subsequent use in a variety of biomedical applications, including enzymatic and chemoenzymatic glycorandomization. | 12-15-2011 |
| 20110305760 | TISSUE REGENERATION SYSTEM - A system for growing tissue based upon layers of an inorganic extracellular matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential growth factor delivery upon its dissolution. | 12-15-2011 |
| 20110300604 | RECOMBINANT INFLUENZA VECTORS WITH TANDEM TRANSCRIPTION UNITS - The invention provides a composition useful to prepare influenza viruses, e.g., in the absence of helper virus, using vectors which include tandem transcription cassettes containing PolI and/or PolII promoters. | 12-08-2011 |
| 20110281942 | Tautomycetin and Tautomycetin Analog Biosynthesis - The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function. | 11-17-2011 |
| 20110269231 | PROTEOGLYCAN-BINDING PEPTIDES THAT MODULATE STEM CELL BEHAVIOR - Biomaterials presenting synthetic peptides and methods of preparing biomaterials are disclosed. More particularly, the disclosure is directed to biomaterials including a substrate including a synthetic peptide thereon, wherein the synthetic peptide is selected from synthetic proteoglycan-binding peptides, synthetic glycosaminoglycan-binding peptides, and combinations thereof. The present disclosure is further directed to methods of preparing the biomaterials for use in sequestering endogenous proteoglycans and endogenous glycosaminoglycans, increasing stem cell proliferation, reducing spontaneous stem cell differentiation, and enhancing induced osteogenic differentiation of mesenchymal stem cells. | 11-03-2011 |
| 20110262460 | BLOOD-BRAIN BARRIER TARGETING ANTIBODIES - This invention provides antibodies that bind brain endothelial cell receptors resulting in endocytosis/transcytosis of the receptor and bound ligands. In some embodiments, the ligand comprises the antibody in combination with a pharmaceutically active compound and the antibody directs delivery of the compound across the blood brain barrier (BBB). The invention also provides methods of identifying endothelial cell specific antibodies by panning the library against cultured cell monolayers. The invention further allows for identifying endothelial cell receptors that bind the antibody thereby providing target receptors against which to isolate further cognate ligands and their associated transport systems and by which to identify transcytosis transporters targeted by the antibodies. | 10-27-2011 |
| 20110220887 | LARGE-AREA, FREE-STANDING METAL OXIDE FILMS AND TRANSISTORS MADE THEREFROM - The present invention provides continuous, free-standing metal oxide films and methods for making said films. The methods are able to produce large-area, flexible, thin films having one or more continuous, single-crystalline metal oxide domains. The methods include the steps of forming a surfactant monolayer at the surface of an aqueous solution, wherein the headgroups of the surfactant molecules provide a metal oxide film growth template. When metal ions in the aqueous solution are exposed to the metal oxide film growth template in the presence of hydroxide ions under suitable conditions, a continuous, free-standing metal oxide film can be grown from the film growth template downward into the aqueous solution. | 09-15-2011 |
| 20110195931 | METHODS AND COMPOSITIONS FOR REDUCING NEURONAL CELL DEATH - Methods and compositions involving a class of boron-protected phenylphosphine agents having increased cell permeability and having improved chemical stability for treating or for preventing neuronal cell death-related diseases or conditions in a human or a non-human animal. | 08-11-2011 |
| 20110195868 | METHODS AND COMPOSITIONS FOR GENETICALLY DETECTING IMPROVED MILK PRODUCTION TRAITS IN CATTLE - An isolated nucleic acid molecule comprising a polymorphic site selected from the group consisting of positions 164, 269, 284, 407 and 989 of SEQ ID NO: 1, an array or a kit comprising the same. Also provided are a method for detecting single nucleotide polymorphism (SNP) in bovine proteinase inhibitor (PI) gene, a method for haplotyping a bovine cell, a method for progeny testing of cattle based on said haplotyping, a method for selectively breeding of cattle based on haplotyping a parent animal. The present invention further provides a method for testing a dairy cattle for its milk production trait, comprising haplotyping its cells, wherein a cattle having haplotypes 1, 3, 4 or 5 indicates that the cattle has desirable milk production trait. Haplotype 1 indicates that the cattle has the most desirable milk production trait. | 08-11-2011 |
| 20110195498 | LIQUID CRYSTALLINE SUBSTRATES FOR CULTURING CELLS - The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells. | 08-11-2011 |
| 20110190886 | BRAIDED TERTIARY NANOFIBROUS STRUCTURE FOR LIGAMENT, TENDON, AND MUSCLE TISSUE IMPLANT - A fabricated braided nanofibrous structure having nanofiber bundles that independently have nanofibers oriented in a uniaxial direction and methods of preparing braided nanofibrous structures. More specifically, the braided nanofibrous structures have at least three nanofiber bundles, wherein the nanofiber bundles are braided together and each nanofiber bundle independently includes at least two nanofibers oriented in a uniaxial direction. The braided nanofibrous structures may be inserted into a region of damaged ligament, tendon, or muscle in a subject. | 08-04-2011 |
| 20110183357 | DEVICE AND METHODS FOR LIQUID CRYSTAL-BASED BIOAGENT DETECTION - The present invention provides liquid crystal-based devices and methods for bioagent detection. In certain aspects, the present invention is directed to devices and methods utilizing liquid crystals and membranes containing polymerized targets that can report the presence of bioagents including, but not limited to, enzymes, antibodies, and toxins. | 07-28-2011 |
| 20110180423 | METHODS FOR REMOVING CONTAMINANTS FROM AQUEOUS SOLUTIONS USING PHOTOELECTROCATALYTIC OXIDIZATION - A photoelectrocatalytic oxidizing device having a photoanode being constructed from a conducting metal such as Ti as the support electrode. Alternatively, the photoanode is a composite electrode comprising a conducting metal such as Ti as the support electrode coated with a thin film of sintered nanoporous TiO | 07-28-2011 |
| 20110171734 | CONJUGATIVE PLASMIDS AND METHODS OF USE THEREOF - The present invention provides novel | 07-14-2011 |
| 20110171665 | P-SELECTIN ASSOCIATED WITH EOSINOPHILS AS A MARKER FOR ASTHMA AND CORRELATING WITH B-1 INTEGRIN ACTIVATION - Methods are provided for the detection of P-selectin associated with eosinophils and for the use of P-selectin as a biological marker for asthma. In one embodiment, the present invention relates to methods for detecting P-selectin in a sample containing eosinophils and quantifying the total number of eosinophils. In another embodiment, the present invention relates a method for determining the proportion of eosinophils that are P-selectin positive and positive for at least partially activated β-1 integrin. In yet another embodiment, the present invention relates to kits for the detection of P-selectin and for the detection of eosinophils that are both P-selectin positive and positive for at least partially activated β-1 integrin. In still yet another embodiment, the invention relates to a method for monitoring a biological condition. | 07-14-2011 |
| 20110171226 | Novel Subtype of Closteridium Botulinum Neurotoxin Type A and Uses Thereof - A novel subtype of type A botulinum neurotoxin (BoNT/A) is disclosed in the application. Methods to purify the neurotoxin as well as uses thereof are also disclosed. | 07-14-2011 |
| 20110165190 | Compositions and Methods for Immunizing Against Immunodeficiency Viruses - Disclosed are compositions, kits, and methods related to HIV vaccines and immunogenic compositions. Typically, the compositions include a mixture of individual and separate DNA polynucleotides that encode different HIV polypeptides or fragments thereof. The mixture of polynucleotides is designed to elicit a broad immunogenic response which may be subsequently boosted by administering a second composition such as a recombinant virus vector composition. The compositions, kits, and methods may be utilized for treating or preventing HIV infection or disease. | 07-07-2011 |
| 20110143424 | RECOMBINANT INFLUENZA VIRUSES FOR VACCINES AND GENE THERAPY - The invention provides compositions and methods useful to prepare segmented, negative strand RNA viruses, e.g., orthomyxoviruses such as influenza A viruses, entirely from cloned cDNAs and in the absence of helper virus. | 06-16-2011 |
| 20110129611 | DECORATING HYDROXYAPATITE BIOMATERIALS WITH MODULAR BIOLOGICALLY ACTIVE MOLECULES - A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation. | 06-02-2011 |
| 20110118539 | ASSOCIATION OF THE PROGESTERONE RECEPTOR WITH FERTILITY - A single nucleotide polymorphic site at position 59752 of the bovine PGR gene is associated with improved fertilization rate or early embryo survival. Disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods. | 05-19-2011 |
| 20110117138 | CHARGE-DYNAMIC POLYMERS AND DELIVERY OF ANIONIC COMPOUNDS - The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided. | 05-19-2011 |
| 20110117135 | Method of Forming Dendritic Cells from Embryonic Stem Cells - This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers. | 05-19-2011 |
| 20110112388 | INTEGRATED MINIATURIZED FIBER OPTIC PROBE - A fiber optic probe having one or more photodetectors bound thereto is provided. By directly integrating thin, flexible photodetectors with an optical fiber, the probes provide a compact structure that increases throughput and decreases cost, making it practical for a clinical use. In some embodiments, the fiber optic probes are small enough for insertion into the shaft of a needle, such as a biopsy needle. | 05-12-2011 |
| 20110112056 | Use of Carbon-2-Modified-Vitamin D Analogs to Induce the Formation of New Bone - It has been discovered that the 2-carbon-modified derivatives of 1α,25-dihydroxyvitamin D | 05-12-2011 |
| 20110104515 | Method of friction stir welding dissimilar metals and workpiece assemblies formed thereby - In a process for friction stir welding together pieces of dissimilar material, a first piece of a second metal is overlaid onto a first piece of a first metal that is dissimilar from the second metal such that at least a portion of the first piece of second metal overlaps a portion of the first piece of first metal. A second piece of the first metal is placed in side-to-side relationship with the first piece of second metal and overlies another portion of the first piece of first metal. The relative arrangement between the second piece of first metal and the first piece of second metal define a joint line overlying the first piece of first metal. The first piece of first metal, the first piece of second metal, and the second piece of first metal are friction stir welded together along the joint line. | 05-05-2011 |
| 20110091878 | DAIRY CATTLE BREEDING FOR IMPROVED MILK PRODUCTION TRAITS IN CATTLE - Nucleic acid molecules comprising a SNP site at position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), which SNP indicates a desirable productive life in a dairy cattle. Also disclosed are an array or a kit comprising the same, a method for detecting the SNPs, a method for progeny testing of cattle, and a method for selectively breeding of cattle. | 04-21-2011 |
| 20110087437 | PROCESS, SOFTWARE ARRANGEMENT AND COMPUTER-ACCESSIBLE MEDIUM FOR OBTAINING INFORMATION ASSOCIATED WITH A HAPLOTYPE - The present invention relates to a method, system and software arrangement for determining the co-associations of allele types across consecutive loci and hence for reconstructing two haplotypes of a diploid individual from genotype data generated by mapping experiments with single molecules, families or populations. The haplotype reconstruction system, method and software arrangement of the present invention can utilize a procedure that is nearly linear in the number of polymorphic markers examined, and is therefore quicker, more accurate, and more efficient than other population-based approaches. The system, method, and software arrangement of the present invention may be useful to assist with the diagnosis and treatment of any disease, which has a genetic component. | 04-14-2011 |
| 20110086824 | (20S,22E)-2-Methylene-19-Nor-22-Ene-1Alpha,25-Dihydroxyvitamin D3 - This invention discloses (20S,22E)-2-methylene-19-nor-22-ene-1α,25-dihydroxyvitamin D | 04-14-2011 |
| 20110086045 | METHOD FOR ENHANCING GROWTH OR INCREASING FEED EFFICIENCY THROUGH REDUCING BINDING BETWEEN ENDOTOXIN AND ITS RECEPTOR IN THE GASTROINTESTINAL TRACT - A method for reducing gastrointestinal inflammation, enhancing growth, or improving feed efficiency in a human or non-human animal is disclosed. The method involves administering to the animal an agent that can reduce the formation of the signal transduction complex of endotoxin, TLR4 and CD14 on the cellular surface of a cell in the gastrointestinal tract of the animal. In a preferred embodiment, an antibody against the extracellular domain of TLR4 or CD14 is used to reduce the formation of the complex. A composition that contains the antibody and an ingestible carrier is also disclosed. Further disclosed is a method for producing a peptide for enhancing growth, improving feed efficiency, or both in a human or non-human animal. | 04-14-2011 |
| 20110082282 | PROCESS OF PREPARING CONJUGATES OF ALLIUM ORGANOSULFUR COMPOUNDS WITH AMINO ACIDS, PEPTIDES, AND PROTEINS - Processes using | 04-07-2011 |
| 20110082123 | 6-Methylvitamin D3 Analogs and Their Uses - This invention discloses 6-methylvitamin D | 04-07-2011 |
| 20110082122 | 19-Nor-Vitamin D Analogs With 1,2- or 3,2-Cyclopentene Ring - 19-nor-vitamin D analogs having an additional cyclopentene ring connecting carbon 1 and carbon 2, or connecting carbon 3 and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds exhibit selective in vitro activities, making them therapeutic agents for the treatment or prophylaxis of some types of cancers, particularly leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. | 04-07-2011 |
| 20110082121 | 1-Desoxy-2-Methylene-19-Nor-Vitamin D Analogs and Their Uses - This invention discloses 1-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-1-desoxy-2-methylene-19-nor-vitamin D | 04-07-2011 |
| 20110081719 | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same - Methods for producing substantially pure cultures of human neural retinal progenitor cells, forebrain progenitor cells, and retinal pigment epithelial cells are disclosed. In addition, the successful differentiation of human embryonic stem cells and human induced pluripotent stem cells through the major developmental stages of human retinogenesis is disclosed. | 04-07-2011 |
| 20110081675 | Metabolic Biomarkers Of Drug-Induced Cardiotoxicity - The invention provides methods and biomarkers for assessing cardiac metabolic response to pharmaceuticals, environmental agents, chemical compounds and biologic therapies. The invention provides methods for identifying cellular metabolites secreted by primary cardiomyocytes, cardiomyocyte precursor cells, clonal cardiomyocytes derived from adult human heart, immortalized cardiomyocytes, human embryonic stem cell (hESC)-derived cardiomyocytes, human induced pluripotent stem cell (iPS)-derived cardiomyocytes, or any cell displaying cardiomyocyte-specific markers in response to exposure to pharmaceuticals, environmental agents, chemical compounds and biologic therapies that are cardiotoxic. Cardiomyocyte-secreted cellular metabolites provide metabolic signatures of cardiotoxicity, and can be used to screen pharmaceutical agents, lead and candidate drug compounds, biologics, and other therapeutics for cardiotoxic effects. | 04-07-2011 |
| 20110076682 | Over-production of secondary metabolites by over-expression of the VEA gene - The invention provides a general and facile method to obtain secondary metabolites from fungal sources. The invention is based on the discovery that the fungal gene veA and protein encoded thereby regulates the activity of multiple secondary metabolite gene clusters in fungi. Over expression of the gene veA provides increased production of secondary metabolites in engineered cells. In particular, such a method of increasing secondary metabolite production allows the production of improved yields of valuable secondary metabolite products. | 03-31-2011 |
| 20110071222 | POTENTIATORS OF INSULIN SECRETION - The present invention relates to a recognition that an analog of αKG can increase glucose-induced insulin secretion in vitro and in vivo in animals, particularly in mammals, and more particularly in humans and in rodents. By employing the methods of the invention, insulin secretion can be increased. | 03-24-2011 |
| 20110065981 | Methods and Compositions for Improved Fertilization and Embryonic Survival - Single nucleotide polymorphic sites at positions 19069 and 25402 of the bovine STAT3 gene are associated with improved fertilization rate and/or improved embryo survival rate. The interactions between these two polymorphisms, and between them and the bovine STAT1 gene and fertilization and early embryonic survival rates were also disclosed. The interactions between STAT3 SNPs, and between STAT1 and STAT3 SNP19069 were highly significant for embryonic survival rate. Also disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods. | 03-17-2011 |
| 20110059927 | Calcium Formate For Use As A Dietary Supplement - A calcium formate composition for oral administration to an individual for the purpose of supplementary dietary calcium is disclosed. | 03-10-2011 |
| 20110053280 | Detection of Post-Translationally Modified Peptides with Liquid Crystals - A method for differentiating between a post-translationally modified peptide and a peptide contained in a sample, comprising: (a) contacting the sample with a peptide attachment surface to create a peptidized surface, wherein the sample includes at least one functional group; (b) contacting the peptidized surface with a recognition reagent that selectively binds or forms a complex with the post-translationally modified peptide in the sample to provide an incubated surface; and (c) contacting a liquid crystal with the incubated surface and detecting presence of post-translationally modified peptide in the sample with the liquid crystal. | 03-03-2011 |
| 20110039909 | METHODS AND MATERIALS FOR REDUCING GLI2 EXPRESSION - Methods and materials for reducing expression of GLI2 are disclosed including nucleic acid molecules such as short hairpin RNAs that direct cleavage of GLI2 encoding transcripts and the use of such molecules for reducing prostate cancer cell growth. | 02-17-2011 |
| 20110027812 | ASSAY FOR ANTIBODIES TO MYCOBACTERIUM PARATUBERCULOSIS - A method of detecting an immune response to a paratuberculosis-specific antigen, comprising incubating a sample from a subject with the paratuberculosis-specific antigen and detecting the presence of an antibody in the sample as an indication of an immune response to the paratuberculosis-specific antigen. The antigen may be obtained from a novel | 02-03-2011 |
| 20110022085 | BIOLOGICALLY ACTIVE SUTURES FOR REGENERATIVE MEDICINE - The present disclosure generally relates to biodegradable and bioresorbable materials having a mineral layer on the surface of the material. More particularly, the disclosure relates to biodegradable and bioresorbable orthopedic devices having a degradable mineral layer on the surface thereof that can be used as a delivery vehicle for biological substances. Also provided are various methods of using the mineralized devices in tissue regeneration, including bone tissue engineering, and methods for producing the mineralized devices. | 01-27-2011 |
| 20110014420 | PHOTOPATTERNABLE IMAGING LAYERS FOR CONTROLLING BLOCK COPOLYMER MICRODOMAIN ORIENTATION - The present invention provides structures including a substrate, a crosslinked polymer film disposed over the substrate, and a patterned diblock copolymer film disposed over the crosslinked polymer film. The crosslinked polymer comprises a random copolymer polymerized from a first monomer, a second monomer, and a photo-crosslinkable and/or thermally crosslinkable third monomer, including epoxy-functional or acrylyol-functional monomers. Also disclosed are methods for forming the structures. | 01-20-2011 |
| 20110007261 | ANALYTE DETECTION USING LIQUID CRYSTALS - Devices and methods for using changes in the defects in micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide (LPS), are disclosed. The dispersed liquid crystal microdomains are exposed to the test sample, and any changes in the number of defects in the liquid crystal microdomains are detected by detecting changes in the anchoring configuration of the microdomains. Such changes in anchoring configuration indicate the presence of analyte in the test sample. | 01-13-2011 |
| 20110003382 | USE OF CORTICOSTERONE FOR INCREASING EGG ANTIBODY - Methods for increasing antigen-specific egg yolk antibody titer and eggs having increased antigen-specific egg yolk antibody titer are disclosed. More specifically, the method for increasing antibody titer may include the steps of: administering to an egg-laying animal a corticosteroid; and then, exposing the animal to an immunogenic dose of the antigen. | 01-06-2011 |
| 20100317597 | GLYCOMACROPEPTIDE MEDICAL FOODS FOR NUTRITIONAL MANAGEMENT OF PHENYLKETONURIA AND OTHER METABOLIC DISORDERS - Medical foods containing glycomacroprotein and additional supplemented amounts of arginine, leucine, and optionally other amino acids, such as tyrosine, are disclosed. The medical foods can be used to provide the complete protein requirements for patients having metabolic disorders such as phenylketonuria. | 12-16-2010 |
| 20100308429 | FLEXIBLE LATERAL PIN DIODES AND THREE-DIMENSIONAL ARRAYS AND IMAGING DEVICES MADE THEREFROM - Flexible lateral p-i-n (“PIN”) diodes, arrays of flexible PIN diodes and imaging devices incorporating arrays of PIN diodes are provided. The flexible lateral PIN diodes are fabricated from thin, flexible layers of single-crystalline semiconductor. A plurality of the PIN diodes can be patterned into a single semiconductor layer to provide a flexible photodetector array that can be formed into a three-dimensional imaging device. | 12-09-2010 |
| 20100304405 | COMBINATORIAL DISCOVERY OF ENZYMES WITH UTILITY IN BIOMASS TRANSFORMATION - Methods for the cell-free identification of polypeptide and polypeptide combinations with utility in biomass transformation, as well as specific novel polypeptides and cell-free systems containing polypeptide combinations discovered by such methods are disclosed. | 12-02-2010 |
| 20100281580 | USE OF A GENE ENCODING A HISTIDINE PROTEIN KINASE TO CREATE DROUGHT RESISTANT PLANTS - Plant expression vectors that include promoter sequences operably linked to heterologous ATHK1 polynucleotides, or complements thereof, encoding polypeptides at least 95% identical to SEQ ID NO:26, where the polynucleotides encode polypeptides that confers drought resistance in the plants. Also provided are transgenic plants with increased drought resistance, methods for creating such plants, overexpressors, and underexpressors of ATHK1. Methods for enhancing drought resistance in plants are also provided. | 11-04-2010 |
| 20100275720 | TWO-AXIS NON-SINGULAR ROBOTIC WRIST - In a robotic system having a two-axis robotic wrist connected to a reference member, the wrist has a movable member movable relative to the reference member in pitch and yaw. A first serial chain linkage connects the movable member to the reference member and a second serial chain linkage connects the movable member to the reference member in parallel relationship with the first serial chain linkage. The linkages are configured to constrain the movable to spherical movement, and such that the robotic wrist is non-singular, non-overconstrained, and non-overactuated. Actuation of a pair of revolute joints connected to the reference member deflects the movable member in pitch and yaw. The roll angle resulting from deflection in pitch and yaw is that of an intersecting-shaft constant-velocity coupling connecting the reference member to the movable member. | 11-04-2010 |
| 20100273681 | COMBINATORIAL CHEMISTRY REACTION CELL WITH OPTICAL TWEEZERS - Methods for synthesizing chain molecules on particles in a multi-stream laminar flow, microfluidic reaction cells in which the methods can be carried out, and microfluidic systems incorporating the microfluidic reaction cells are provided. The methods, cells and systems are well suited for the rapid, large-scale production of chain biomolecules, such as oligonucleotides, in parallel. | 10-28-2010 |
| 20100267655 | Glycosylated Warfarin Analogs and Uses Thereof - The present invention discloses a set of glycosylated warfarin analogs which are useful as anti-tumor or anti-metastatic agents and as reagents for studying sugar uptake in cells. | 10-21-2010 |
| 20100247572 | VIRUSES ENCODING MUTANT MEMBRANE PROTEIN - A method to prepare viruses with a mutant membrane protein gene, and viruses obtained by the method, are provided. | 09-30-2010 |
| 20100233729 | DETECTING INTERACTIONS AT BIOMIMETIC INTERFACES WITH LIQUID CRYSTALS - A method of forming a liquid crystal device, includes: contacting an aqueous solution comprising a surfactant and a receptor molecule with a top surface of a liquid crystal. The liquid crystal is in a holding compartment of a substrate, and the receptor molecule is adsorbed on the top surface of the liquid crystal forming an interface between the liquid crystal and the aqueous solution. The receptor molecule is different than the surfactant. A method of detecting a compound in a flowing stream includes passing an aqueous solution over a top surface of a liquid crystal in a holding compartment of a substrate. The method also includes determining whether a change in the orientation of the liquid crystal occurs as the aqueous solution is passed over the top surface of the liquid crystal. A change in the orientation of the liquid crystal indicates the presence of the compound in the flowing stream. | 09-16-2010 |
| 20100221513 | SELF SINTERING TRANSPARENT NANOPOROUS THIN-FILMS FOR USE IN SELF-CLEANING, ANTI-FOGGING, ANTI-CORROSION, ANTI-EROSION ELECTRONIC AND OPTICAL APPLICATIONS - The invention is directed to an article made by the steps comprising providing either a plastic or glass substrate member, pre-heating the substrate member, providing a first liquid sol comprising water, methanol, and nanoparticulate SiO | 09-02-2010 |
| 20100210734 | METHOD OF USING CALCITRIOL FOR TREATING INTRAOCULAR DISEASES ASSOCIATED WITH ANGIOGENESIS - The present invention provides a method of treating pathologies resulting from neovascular growth in the eye such as those manifested as retinopathy of prematurity, diabetic retinopathy and macular degeneration. The invention comprises the administration of an effective amount of calcitriol that is administered at doses less than toxicity and results in a significant reduction in the formation of neo-vascular growth. The invention can be used to treat existing diseases or prophylactically to treat those at risk. | 08-19-2010 |
| 20100210575 | STRUCTURING EFFECT OF CHOLESTEROL IN PEG-PHOSPHOLIPID MICELLES, DRUG DELIVERY OF AMPHOTERICIN B, AND COMBINATION ANTIFUNGALS - The disclosure herein relates to embodiments of compositions and methods in connection with polymeric micelles including PEG-phospholipids. Embodiments also relate to the controlled release of pharmaceutical agents in the context of drug delivery. Further disclosed are embodiments of PEG-DSPE/Cholesterol micelle formulations prepared with an antifungal agent, Amphotericin B, with capabilities including slow release of the agent in a deaggregated state. In embodiments, micellar preparations with Amphotericin B are compatible with solubility in aqueous salt solutions, thus allowing for concurrent co-administration of other pharmaceutical agents and/or sodium supplementation. In embodiments, polymeric micelle compositions are employed in combination antifungal therapeutic approaches such as Amphotericin B and other antifungal agents. Also disclosed herein are compositions and methods relating to combinations including AmB:PEG-DSPE, rapamycin:PEG-DSPE, and/or 5-fluorocytosine. | 08-19-2010 |
| 20100209509 | BIFUNCTIONAL-MODIFIED HYDROGELS - Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels. | 08-19-2010 |
| 20100209425 | Blood-Brain Barrier Targeting Anti-bodies - This invention provides antibodies that bind brain endothelial cell receptors resulting in endocytosis/transcytosis of the receptor and bound ligands. In some embodiments, the ligand comprises the antibody in combination with a pharmaceutically active compound and the antibody directs delivery of the compound across the blood brain barrier (BBB). The invention also provides methods of identifying endothelial cell specific antibodies by panning the library against cultured cell monolayers. The invention further allows for identifying endothelial cell receptors that bind the antibody thereby providing target receptors against which to isolate further cognate ligands and their associated transport systems and by which to identify transcytosis transporters targeted by the antibodies. | 08-19-2010 |
| 20100203164 | Therapeutic Treatment of Cancer and Dysplasia of the Cervix or Vagina Using Estrogen Antagonists - A method for treatment of cervical or vaginal cancer and their associated dysplasia, including the steps of identifying a human cervical or vaginal cancer and/or dysplasia patient, administering an effective amount of an estrogen antagonist therapy to the patient, wherein the amount is effective to reduce cancer and dysplasia symptoms, and observing a reduction of cancer and dysplasia symptoms in the patient. | 08-12-2010 |
| 20100199386 | CONTROL OF COLD-INDUCED SWEETENING AND REDUCTION OF ACRYLAMIDE LEVELS IN POTATO OR SWEET POTATO - The present invention is directed to methods and compositions to eliminate cold storage-induced sweetening of potato or sweet potato. The invention is accomplished in part by silencing the vacuolar acid invertase gene using RNAi technology. The resulting potatoes withstand cold storage without significant hexogenesis, producing potatoes or sweet potatoes that have reduced Maillard reactions when fried in hot oil. The fried products accumulate significantly lower levels of acrylamide compared to controls. | 08-05-2010 |
| 20100179344 | 2-Alkylidene-18,19-Dinor-Vitamin D Compounds - 2-alkylidene-18,19-dinor-vitamin D compounds are disclosed as well as pharmaceutical uses for these compounds and methods of synthesizing these compounds. These compounds are characterized by low bone calcium mobilization activity and high intestinal calcium transport activity. This results in novel therapeutic agents for the treatment and prophylaxis of diseases where bone formation is desired, particularly osteoporosis, as well as autoimmune diseases such as multiple sclerosis, diabetes mellitus and lupus. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. These compounds also increase both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements. | 07-15-2010 |
| 20100160267 | Treatment of Inflammatory Bowel Disease With 2-Methylene-19-Nor-Vitamin D Compounds - A method of preventing and/or treating inflammatory bowel disease, particularly ulcerative colitis and Crohn's disease, is disclosed. The method involves administering a 2-methylene-19-nor-vitamin D compound in an amount effective to treat the disease. The administration of a 2-methylene-19-nor-vitamin D compound also prevents the development of or delays the onset of inflammatory bowel disease in susceptible individuals. The preferred compounds are 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol and 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D | 06-24-2010 |
| 20100159457 | SYSTEM AND METHOD FOR PRESENTING DNA BINDING SPECIFICITIES USING SPECIFICITY LANDSCAPES - A system and method for analyzing DNA binding specificities is provided. The potential binding motifs are compared to a plurality of DNA sequences. The DNA sequences are plotted within a specificity landscape, which provides details otherwise unavailable, relating to binding affinities and binding specificities of the motif-sequence combination. | 06-24-2010 |
| 20100144548 | VECTOR SYSTEMS - The present invention relates generally to the field of molecular biology and genomics. More specifically, the present invention concerns the cloning of nucleic acid molecules and the production of nucleic acid libraries, as well as the expression of recombinant proteins and bactofection. | 06-10-2010 |
| 20100137158 | GFABS: GFP-based biosensors possessing the binding properties of antibodies - A family of GFP scaffolds capable of accommodating two proximal, randomized binding loops is disclosed. GFP-based binders binding with nanomolar affinity are developed from a library of these GFP scaffolds. | 06-03-2010 |
| 20100119866 | LOW-TEMPERATURE SYNTHESIS OF INTEGRATED COATINGS FOR CORROSION RESISTANCE - Methods for the low-temperature synthesis of an integrated, corrosion-resistant coating structure for metal substrates by means of multi-component pack cementation are provided. The synthesis of the integrated coating structures at low temperatures can avoid or minimize degradation of the mechanical properties of the substrates. The integrated coating structures can increase the lifetime of high temperature steels under severe steam environments and, therefore, provide a technological enabler for the high-temperature operation of steam power generation plants. | 05-13-2010 |
| 20100081199 | Generation of mature myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+progenitors - A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed. | 04-01-2010 |
| 20100080825 | FILOVIRUS VECTORS AND NONINFECTIOUS FILOVIRUS-BASED PARTICLES - Cloned filovirus genomic cDNA and methods of using the cDNA are provided. Further provided are noninfectious lipid encapsulated filovirus-based particles. | 04-01-2010 |
| 20100077238 | ENERGY EFFICIENCT POWER SUPPLY SYSTEM - An energy efficient power supply system is disclosed. The energy efficient power supply system comprises a plurality of power supply units and the power supply system may be coupled to the control logic. The control logic may be coupled to the power monitor unit. The power monitor unit may determine a power consumption value, which may represent power requirement of a power consuming system such as a computer system. The control logic may determine the power supply units of the plurality of power supply units that are to be activated to provide power to match the power requirement. The control logic may identify the power supply units that may be activated to operate at a maximum efficiency value while providing power specified by the power consumption value. | 03-25-2010 |
| 20100071063 | SYSTEM FOR AUTOMATIC DETECTION OF SPYWARE - An automatic system for spyware detection and signature generation compares packets of output from a computer in response to standard user inputs, to packets of a standard output set derived from a known clean machine. Differences between these two packet sets are analyzed with respect to whether they relate to unknown web servers and whether they incorporate user-derived information. This analysis is used to provide an automatic detection of and signature generation for spyware infecting the machine. | 03-18-2010 |
| 20100062525 | OPTICALLY RESPONSIVE AND MECHANICALLY TUNABLE COLLOID-IN-LIQUID CRYSTAL GELS - Colloidal liquid crystal gels (CLCGs), sensors incorporating the CLCGs, culture substrates made from the CLCGs, and patterned films and molded articles made from the CLCGs are provided. The CLCGs are composite liquid crystal materials comprising networks of particles having liquid crystal domains dispersed therein. | 03-11-2010 |
| 20100062014 | H3 EQUINE INFLUENZA A VIRUS - The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof. | 03-11-2010 |
| 20100047838 | YEAST GENES THAT AFFECT VIRAL REPLICATION - An antiviral agent comprising an altered MAB1, MAB2, MAB3, or OLE1 gene, gene homologs or related genes is disclosed. In another embodiment, the present invention is a method of creating a virus resistant organism comprising creating a transgenic organism comprising an antiviral agent selected from the group of altered MAB1 genes, MAB2 genes, MAB3 genes or OLE1 genes, homologs of these genes, related genes and combinations of these genes and homologs. | 02-25-2010 |
| 20100042375 | System and Method for Designing Proteins - Various embodiments of the present invention include systems and methods for redesigning proteins. Various embodiments of the present invention present bioinformatic methods to redesign proteins to be more stable through optimization of local structural entropy. The redesigned proteins display significant increases in their thermal stabilities while retaining catalytic activity, and demonstrate a broadly applicable method. | 02-18-2010 |
| 20100041604 | NOVEL ANTIVIRAL PEPTIDES AGAINST INFLUENZA VIRUS - The present disclosure generally relates to peptides having antiviral properties. More particularly, the invention relates to peptides exhibiting activity against influenza viruses, to pharmaceutical compositions comprising the peptides, and to methods of using the peptides to prevent and/or treat influenza viral infections. | 02-18-2010 |
| 20100040642 | NOVEL PEPTIDE ADJUVANT FOR INFLUENZA VACCINATION - The present disclosure generally relates to peptides having adjuvant properties, vaccines comprising the adjuvant peptides, and their use in prophylaxis or therapy for influenza. More particularly, the invention relates to adjuvant peptides that induce aggregation of influenza virus. The peptides can be included in influenza vaccines to increase the immune response to the vaccine. | 02-18-2010 |
| 20100035266 | Methods for Assessing Risk of Alzheimer's Disease in a Patient - Disclosed are methods for diagnosis or prognosis of Alzheimer's disease in a patient. The methods may include assessing whether a patient has Alzheimer's disease or assessing a patient's risk for developing Alzheimer's disease. The methods typically include determining, either directly or indirectly, whether the patient has mutations, such as single nucleotide polymorphisms, in a plurality of genes that encode gene products that function in steroid biosynthesis. | 02-11-2010 |
| 20100021344 | BETA-PEPTIDE LYOTROPIC LIQUID CRYSTALS AND METHODS OF MANUFACTURE AND USE THEREOF - The present invention provides materials and methods that make liquid crystal phases accessible with relatively short β-peptides in aqueous solvents. | 01-28-2010 |
| 20100015639 | Methods and Kits to Detect and Monitor Ovarian Cancer and Preeclampsia - The present invention provides methods and kits related to a prognostic, and, in certain embodiments, diagnostic indicator for ovarian cancer which comprises measuring the level of MUC16 bound to immune cells. The level of MUC16 bound to immune cells can by itself be an indicator of disease regression or recurrence, or this indicator can be used in conjunction with assays for serum CA125 and other diagnostic markers. The invention further provides methods and kits related to the detection of ovarian cancer by measuring levels of Siglec-9 expression on immune cells. As well, related methodologies are provided for the detection of preeclampsia in pregnant human subjects. | 01-21-2010 |
| 20100015429 | METAL SUBSTRATES INCLUDING METAL OXIDE NANOPOROUS THIN FILMS AND METHODS OF MAKING THE SAME - The present disclosure is directed to a metal-containing apparatus including a substrate member constructed of a metal that is highly resistant to pitting corrosion and wear in aggressive media. An exemplary metal-containing apparatus is a plate heat exchanger. The metal includes an oxidation layer on the surface thereof and a thin metal oxide nanoporous film on top of the oxidation layer. The nanoporous film is highly compliant and is comprised of oxygen and aluminum, titanium, silicon, zirconium and combinations thereof. | 01-21-2010 |
| 20090326212 | METHOD AND APPARATUS FOR PARALLEL SYNTHESIS OF CHAIN MOLECULES SUCH AS DNA - Synthesis of chain molecules such as DNA is carried out in a conduit having an interior channel with an inlet end and an outlet end. At least one wall of the conduit is substantially transparent to selected wavelengths of light. Solid carrier particles are contained within the interior channel of the conduit. A plurality of controllable light sources are mounted at spaced locations along the length of the transparent wall of the conduit to allow selective illumination of separated sections of the particles within the conduit. When a light source is turned on, a photodeprotecting group is removed from the carrier particles in the section that is illuminated by the light source. A reagent containing a selected base is flowed through the conduit so that the base will attach to the carrier particles in those sections which have been exposed to light and deprotected. | 12-31-2009 |
| 20090326055 | Chroman-Derived Compounds For The Treatment Of Cancer - The present invention provides methods for inhibiting the growth of androgen-independent prostate cancer tumor cells in a human comprising administering to the human. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived compounds useful in the alleviation of cancer. | 12-31-2009 |
| 20090324640 | NEURAMINIDASE-DEFICIENT LIVE INFLUENZA VACCINES - Attenuated, neuraminidase deficient influenza virus, and compositions and methods to prepare that virus, are provided. | 12-31-2009 |
| 20090317829 | High-throughput assay for sugar-mediated drug transport - The invention provides a rapid, quantitative assay to directly assess the impact of a diverse range of sugars upon the sugar-mediated uptake of corresponding sugar-conjugates into various cell types. | 12-24-2009 |
| 20090311669 | SIGNAL FOR PACKAGING OF INFLUENZA VIRUS VECTORS - The invention provides a packaging (incorporation) signal for influenza virus vectors, and methods of using the signal to transmit and maintain influenza viral and foreign nucleic acid in virus and cells. | 12-17-2009 |
| 20090306344 | METHOD OF REDUCING THE VISCOSITY OF MUCUS - Disclosed is a pO157 plasmid-specified polypeptide found in | 12-10-2009 |
| 20090299098 | Catalytic Metathesis of Secondary Amides - The invention provides methods and reagents for the metathesis of secondary amides via a transacylation mechanism employing catalytic quantities of an imide initiator and a Brønsted base. Equilibrium-controlled exchange between various amide reactant pairs is demonstrated for substrates bearing a variety of N-alkyl and N-aryl substituents. | 12-03-2009 |
| 20090293597 | SYSTEM AND METHOD FOR MONITORING COMBUSTION CHAMBER PRESSURE AND CONTROL SYSTEM USING THE SAME - In a monitoring system and method for monitoring pressure in a combustion chamber of an internal combustion engine, a sensor is operable to sense movement of a valve while the valve is in its closed position. The sensor generates data indicative of the sensed movement of the valve. A control system is in communication with the sensor to receive the data indicative of the sensed movement of the valve in the closed position thereof. The control system is operable to determine the pressure in the combustion chamber based at least in part on the sensed movement of the valve. In other aspects, operation of the engine is adjusted based at least in part on the determined pressure in the combustion chamber. | 12-03-2009 |
| 20090291312 | OXIDATION RESISTANT COATINGS FOR ULTRA HIGH TEMPERATURE TRANSITION METALS AND TRANSITION METAL ALLOYS - The invention provides oxidation resistant coatings for transition metal substrates and transition metal alloy substrates and method for producing the same. The coatings may be multilayered, multiphase coatings or gradient multiphase coatings. In some embodiments the transition metal alloys may be boron-containing molybdenum silicate-based binary and ternary alloys. The coatings are integrated into the substrates to provide durable coatings that stand up under extreme temperature conditions. | 11-26-2009 |
| 20090275485 | Reversible Natural Product Glycosyltransferase-Catalyzed Reactions, Compounds and Related Methods - The present invention relates to methods of use of glycosyltransferases and related novel compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomolecules and numerous one-pot reactions for generation of new biomolecules having varied backbones such as enediynes, vancomycins, bleomycins, anthracyclines, macrolides, pluramycins, aureolic acids, indolocarbazoles, aminglycosides, glycopeptides, polyenes, coumarins, benzoisochromanequinones, calicheamicins, erythromycin, avermectins, ivermectins, angucyclines, cardiac glycosides, steroids or flavinoids. In preferred embodiments, the invention specifically relates to biosynthesis of anticancer (the enediyne calicheamicin, CLM), anthelmintic agents (the macrolides avermectin, ivermectin and erythromycin) and antibiotic (the glycopeptide vancomycin, VCM) natural product-based drugs developed by reversible, bidirectional glycosyltransferase-catalyzed reactions. | 11-05-2009 |
| 20090260750 | MOLECULAR TRANSFER PRINTING USING BLOCK COPOLYMERS - Methods of creating and transferring chemical patterns and physical patterns of deposited materials or molecules using block copolymers are provided. The methods involve providing block copolymer materials blended with one or more transfer molecules or inks. The differences in chemistry of the blocks of the copolymer that result in micro-phase separation (e.g., self-assembly into nanoscale domains) also allow inks to be sequestered into specific blocks. By designing the ink molecules to react, adsorb, or otherwise interact with a second substrate, inks are transferred to the second substrate in a pattern dictated by the pattern of block copolymer domains present at the surface of the block copolymer film. | 10-22-2009 |
| 20090253624 | Pharmacologically active antiviral peptides and methods of use - This invention relates to peptides having antiviral properties. The antiviral peptides comprise membrane transiting peptides, and active fragments and derivatives of such peptides. The antiviral peptides exhibit activity against a broad spectrum of viruses, including enveloped and nonenveloped viruses, and are used in pharmaceutical compositions to prevent and/or treat viral infections. | 10-08-2009 |
| 20090246830 | RECOMBINANT INFLUENZA VIRUSES FOR VACCINES AND GENE THERAPY - A method for producing influenza virus particles for preparation of a vaccine. The method comprises growing reassortant influenza viruses to produce virus particles and recovering the produced virus particles. The reassortant influenza viruses are produced in cultured cells in the absence of helper virus by introducing into the cultured cells expression vectors sufficient to produce genomic vRNA or antigenomic vRNA (cRNA) segments in the cells of reassortant influenza viruses. The method produces a nucleoprotein and an RNA dependent RNA polymerase in the cells so that RNP complexes containing the genomic vRNA segments of the reassortant influenza viruses are formed. The method uses expression vectors containing HA, NA, non-HA and non-NA vRNA segments in which the HA and NA vRNA segments are HA and NA vRNA segments of a viral strain different from a strain that contains all of the non-HA and non-NA vRNA segments. | 10-01-2009 |
| 20090239888 | Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation - Compositions and uses of mGluR | 09-24-2009 |
| 20090230325 | Method For Measuring Activity of a Specific Fraction of Albumin - Methods of measuring the SFA and sPLA | 09-17-2009 |
| 20090206054 | MATERIALS AND METHODS FOR CREATING IMAGING LAYERS - The present invention provides patterned features of dimensions of less than 50 nm on a substrate. According to various embodiments, the features may be “Manhattan” style structures, have high aspect ratios, and/or have atomically smooth surfaces. The patterned features are made from polymer brushes grafted to a substrate. In some embodiments, the dimensions of the features may be determined by adjusting the grafting density and/or the molecular weight of the brushes. Once the brushes are patterned, the features can be shaped and reshaped with thermal or solvent treatments to achieve the desired profiles. The chemical nature of the polymer brush is thus independent of the patterning process, which allows for optimization of the polymer brush used for specific applications. Applications include masks for pattern transfer techniques such as reactive ion etching. | 08-20-2009 |
| 20090196488 | DENSITY MULTIPLICATION AND IMPROVED LITHOGRAPHY BY DIRECTED BLOCK COPOLYMER ASSEMBLY - Methods to pattern substrates with dense periodic nanostructures that combine top-down lithographic tools and self-assembling block copolymer materials are provided. According to various embodiments, the methods involve chemically patterning a substrate, depositing a block copolymer film on the chemically patterned imaging layer, and allowing the block copolymer to self-assemble in the presence of the chemically patterned substrate, thereby producing a pattern in the block copolymer film that is improved over the substrate pattern in terms feature size, shape, and uniformity, as well as regular spacing between arrays of features and between the features within each array compared to the substrate pattern. In certain embodiments, the density and total number of pattern features in the block copolymer film is also increased. High density and quality nanoimprint templates and other nanopatterned structures are also provided. | 08-06-2009 |
| 20090148509 | ENCAPSULATION AND DEAGGREGATION OF POLYENE ANTIBIOTICS USING POLY(ETHYLENE GLYCOL)-PHOSPHOLIPID MICELLES - Amphotericin B (or other hydrophobic compound) is encapsulated in a deaggregated form in micelles of monomethoxy poly(ethylene glycol)-phospholipid (as specifically exemplified, the phospholipid is 1,2 di-stearoyl-sn-glycero-3-phosphatidyl ethanolamine) formed by solvent evaporation. Advantageously, the hydration of the dried drug-polymer film is carried at between about 25° C. and about 80° C. The micelles can be reconstituted with the Amphotericin B (or other hydrophobic compound) in a deaggregated state and safely used in therapy for fungal infections of humans or animals, especially for systemic fungal infections, or other desired application. The polyene micellar formulations described herein are reduced in toxicity as compared with those polyene formulations in which there is significant occurrence of aggregated polyenes. | 06-11-2009 |
| 20090124819 | 2-SUBSTITUTED VITAMIN D DERIVATIVES - The object of the present invention is to synthesize novel vitamin D derivatives. | 05-14-2009 |
| 20090123670 | Detecting Interactions at Biomimetic Interfaces with Liquid Crystals - A method of forming a liquid crystal device, includes: contacting an aqueous solution comprising a surfactant and a receptor molecule with a top surface of a liquid crystal. The liquid crystal is in a holding compartment of a substrate, and the receptor molecule is adsorbed on the top surface of the liquid crystal forming an interface between the liquid crystal and the aqueous solution. The receptor molecule is different than the surfactant. A method of detecting a compound in a flowing stream includes passing an aqueous solution over a top surface of a liquid crystal in a holding compartment of a substrate. The method also includes determining whether a change in the orientation of the liquid crystal occurs as the aqueous solution is passed over the top surface of the liquid crystal. A change in the orientation of the liquid crystal indicates the presence of the compound in the flowing stream. | 05-14-2009 |
| 20090118761 | ANEURYSM OCCLUSION DEVICE CONTAINING BIOACTIVE AND BIOCOMPATIBLE COPOLYMER SHELL AND A LIQUID EMBOLIC AGENT - An endovascular device for occluding a vascular aneurysm is disclosed. The device includes a polymeric shell member that, in one embodiment, may be constructed from a bioactive and biocompatible polyurethane-diol-glycosaminoglycan copolymer, and a liquid embolic agent. The copolymer is sufficiently flexible and strong for endovascular delivery into a vascular aneurysm and for use as a polymeric shell for receiving the liquid embolic agent. Upon activation inside of the polymeric shell within the aneurysm, the liquid embolic agent solidifies enabling biological isolation of the aneurysm and improved patient outcomes. | 05-07-2009 |
| 20090099034 | Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers - This invention provides methods for amplifying, detecting, measuring, and identifying miRNAs from biological samples, particularly limited amounts of a biological sample. miRNAs that are differentially expressed in tumor samples and normal tissues are useful as cancer biomarkers for cancer diagnostics. | 04-16-2009 |
| 20090081736 | Methods For Using Mutant RNA Polymerases Wtih Reduced Discrimination Between Non-Canonical Nucleoside Triphosphates - A method for synthesizing a nucleic acid molecule comprising at least one non-canonical nucleoside triphosphate using a mutant polymerase having a reduced discrimination between canonical and non-canonical substrates is disclosed. The method comprises incubating a template nucleic acid in a reaction mixture comprising the mutant nucleic acid polymerase and the appropriate canonical and non-canonical nucleoside triphosphates which are desired substrates for the mutant nucleic acid polymerase. The present invention is also a method of determining the sequence of a nucleic acid molecule using the mutant polymerase to create a nucleic acid molecule comprising at least one non-canonical nucleoside triphosphate. | 03-26-2009 |
| 20090074812 | Influenza M2 protein mutant viruses as live influenza attenuated vaccines - A method to prepare recombinant influenza viruses comprising a mutant M2 protein which has a deletion of two or more residues in the cytoplasmic tail and is attenuated in vivo, is provided, as well the resulting virus and vaccines with the virus. | 03-19-2009 |
| 20090062834 | ANEURYSM OCCLUSION DEVICE CONTAINING BIOACTIVE AND BIOCOMPATIBLE COPOLYMER SHELL AND BIOCOMPATIBLE METALLIC FRAME MEMBER - An endovascular device for occluding a vascular aneurysm is disclosed. The device includes a polymeric shell member that, in one embodiment, may be constructed from a bioactive and biocompatible polyurethane-diol-glycosaminoglycan copolymer, and a biocompatible metallic frame member. The copolymer is sufficiently flexible and strong for endovascular delivery into a vascular aneurysm and for use as a polymeric shell for receiving the biocompatible metallic frame member. The biometallic frame member may include one or more components constructed from a NiTi alloy. | 03-05-2009 |
| 20090061463 | P-Selectin associated with Eosinophils as a marker for asthma and correlating with B-1 integrin activation - Methods are provided for the detection of P-selectin associated with eosinophils and for the use of P-selectin as a biological marker for asthma. In one embodiment, the present invention relates to methods for detecting P-selectin in a sample containing eosinophils and quantifying the total number of eosinophils. In another embodiment, the present invention relates a method for determining the proportion of eosinophils that are P-selectin positive and positive for at least partially activated β-1 integrin. In yet another embodiment, the present invention relates to kits for the detection of P-selectin and for the detection of eosinophils that are both P-selectin positive and positive for at least partially activated β-1 integrin. In still yet another embodiment, the invention relates to a method for monitoring a biological condition. | 03-05-2009 |
| 20090053209 | Blockade of Pin1 Prevents Cytokine Production by Activated Immune Cells - The invention provides pharmaceutical compositions and methods of treating immunological disorders. The invention also provides pharmaceutical compositions and methods of inducing eosinophil apoptosis, and methods for treating eosinophil-associated disorders comprising inducing eosinophil apoptosis in an individual in need thereof. | 02-26-2009 |
| 20090053204 | Functional Genomic Pore Assay For Mixed Cell Populations - A method of assaying nucleotide receptor P2X | 02-26-2009 |
| 20090052623 | Virtual 4D treatment suite - A virtual 4D treatment suite includes a dose calculation module, a gating module, and a dose rate adjustment module. The 4D treatment suite may be used to virtually analyze the impact the motion of a target tissue has on therapy for a particular patient and a proposed treatment plan. For example, for a proposed treatment plan, the dose calculation module may calculate a dose that would be received by a target tissue and an associated dose temporal variation based on an identified movement of the target tissue relative to at least a portion of a treatment field. Based on the calculated expected therapy dose and dose temporal variation, the gating module may determine whether to implement a gating technique for the proposed treatment plan and/or the dose rate adjustment module may determine whether to adjust the dose rate of the proposed treatment plan. | 02-26-2009 |
| 20090036389 | Polymeric Micelle Formulations of Hydrophobic Compounds and Methods - Provided are cosolvent evaporation methods and compositions for improving the solubility of hydrophobic compounds, including therapeutic agents such as anticancer drugs, polyene antibiotics, antilipidemic agents, and hydrophobic compounds used in various industries, and/or for reducing the toxicity of certain hydrophobic therapeutic agents, especially polyene antibiotics, in particular, Amphotericin B (AmB), and therapeutics such as paclitaxel, tamoxifen, an acylated prodrug or an acylated cis-platin, by incorporating these agents within micelles comprising an amphiphilic block-forming copolymer. | 02-05-2009 |
| 20090017444 | Screening method for modulators of viral transcription or replication - The invention provides methods to identify modulators of viral transcription or replication. | 01-15-2009 |
| 20080300210 | Method of Controlling Insects and Virus Transmission - The present invention provides methods and compositions for controlling insects and virus transmission, including a genetic construct for inhibiting virus transmission by an arthropod, a transgenic plant, plant cell or plant tissue, a method of preventing transmission of an arthropod-dependent viral plant disease, a method of delivering an active toxic fragment of a | 12-04-2008 |
| 20080293906 | BIOACTIVE AND BIOCOMPATIBLE POLYURETHANE-BUTHANEDIOL-GLYCOSAMINOGLYCAN SALT COPOLYMERS - A bioactive and biocompatible polyurethane-butanediol-glycosaminoglycan copolymer for use in medical implant devices. The biocompatible urethane component being the reaction product of 4,4′-methylene-di-(p-phenyl isocyanate) and poly(tetramethylene oxide)n and further reacted with 1,4-butanediol, wherein n=10 to 40. The bioactive glycosaminoglycan being a salt of hyaluronic acid, such as a cetylpyridinium salt acid having 5 to 10,000 repeating units or a salt of heparin, such as a dimethyldioctadecylammonium salt of heparin has 5 to 65 repeating units or a suitable salt of dermatan sulfate. The weight content of the bioactive glycosaminoglycan is an amount sufficient to render the copolymer bioactive. The copolymers described herein have excellent hemocompatibility and biocompatibility. | 11-27-2008 |
| 20080293040 | INFLUENZA B VIRUSES WITH REDUCED SENSITIVITY TO NEURAMINIDASE INHIBITORS - An isolated influenza B virus which has reduced sensitivity to one or more neuraminidase (NA) inhibitors, wherein the reduced sensitivity to one or more NA inhibitors is associated with a residue in NA other than Ile at position 222, a residue in NA other than Ser at a position 250, or a residue in NA other than Gly at position 402, as well as methods to detect such a virus or determine agents that inhibit the infection or replication of such as virus, are provided. | 11-27-2008 |
| 20080268504 | Glycorandomization and Production of Novel Vancomycin Analogs - The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or one which is putatively associated with or involved in production of natural secondary metabolites. The glycosyltransferase may show significant flexibility with respect to its NDP-sugar donors and/or its aglycons. NDP-sugar donors may be commercially available, or may be produced by utilizing mutant or wild type nucleotidyltransferases significant flexibility with respect to their substrates. | 10-30-2008 |
| 20080266562 | Image Locking System for Dna Micro-Array Synthesis - An image locking system for DNA micro-array synthesis provides a feedback system to stabilize or lock the image with respect to an image capture device, such as a camera and/or microscope. The image locking system includes the use of detection or reference marks. When a shift in image position is detected, a correction signal is sent to one of two mirrors, moving the image to correct for the shift in image position. The system comprises a first light beam directed towards a micromirror device that forms an alignment pattern on a reaction cell and a second light beam directed towards the micromirror device that forms a micro-array image on an active surface of the reaction cell. A camera captures the alignment pattern and an alignment mark. A computer calculates a correction signal to realign the alignment pattern with the alignment mark when movement is detected. | 10-30-2008 |
| 20080254509 | NUCLEOTIDYL TRANSFERASES WITH ENHANCED NUCLEOTIDE TRIPHOSPHATE FLEXIBILITY - The present invention provides mutant Rm1A enzymes possessing an increased purine/pyrimidine bias in nucleotide triphosphate substrate specificity as compared to a corresponding non-mutated Rm1A enzyme. Such enzymes expand the types of substrates that can be used in enzymatic glycorandomization methods thereby increasing diversity of chemical libraries. | 10-16-2008 |
| 20080248585 | Protein/Peptide Sequencing By Chemical Degradation in the Gas Phase - A fast and sensitive method and device for protein sequencing are disclosed. The method uses a combination of Edman degradation chemistry and mass spectrometry to sequence proteins and polypeptides. A peptide degradation reaction is performed on a polypeptide or protein ion reactant in the gas phase. The reaction yields a first ion product corresponding to a first amino acid residue of the polypeptide or protein reactant and a polypeptide or protein fragment ion. The mass-to-charge ratio for the first ion product, or the polypeptide or protein fragment ion, or both, is then determined. The first amino acid residue of the polypeptide or protein reactant is then identified from the mass-to-charge ratio so determined. | 10-09-2008 |
| 20080237110 | MEMBRANE CASCADE-BASED SEPARATION - The present invention provides counter flow cascade separation systems useful to separate solute/solute pairs present in a solvent. The separation systems include a series of interconnected stages with each stage comprising a diafilter preferentially permeable for one solute. Solute/solute pairs are preferentially separated by the diafilter into permeate and retentate flows. Stages are combined to form separation systems capable of operation approaching an ideal cascade. | 10-02-2008 |
| 20080227762 | LUPEOL ANTI-TUMOR AGENT AND USES THEREOF - The present invention provides a method of treating melanoma comprising parenterally administering to a human a therapeutically effective amount of a parenteral composition of a Lupeol-derived anti-tumor compound. | 09-18-2008 |
| 20080208039 | System and method of performing therapeutic endovascular interventions - A system and method of tracking a medical device and generating an image of a target area. The medical device includes a Helmholtz coil pair to create an imaging field-of-view that extends beyond the tip of the medical device while allowing the tip of the medical device to be visualized. The Helmholtz coil pair provides the ability to generate images forward of the medical device tip to ensure that the tip of the medical device will not puncture the target tissue or vasculature. | 08-28-2008 |
| 20080208031 | Voltage standing wave suppression for MR-guided therapeutic interventions - A system and method of tracking a medical device and generating an image of a target area. The medical device includes a tracking device to create an imaging field-of-view that extends beyond the tip of the medical device while allowing the tip of the medical device to be visualized. The medical device further includes an imaging/visualization device to create an imaging field from the point of view of the medical device. A voltage standing wave suppression device is formed on the exterior surface of the medical device to prevent the formation of voltage standing waves and localized tissue heating. The voltage standing wave suppression device includes two cable traps spaced apart from one another with each cable trap being formed of a closely packed coiled region of a conductor extending the length of the medical device. | 08-28-2008 |
| 20080206890 | BIS(2,9-DI-TERT-BUTYL-1,10-PHENANTHROLINE)COPPER(I) COMPLEXES, METHODS OF SYNTHESIS, AND USES THEROF - The present invention provides homoleptic and heteroleptic copper(I) complexes having sterically demanding ligands, such as the bis(2,9-di-tert-butyl-1,10-phenanthroline)copper(I) complex and related complexes, methods of synthesis of these complexes and uses thereof. These copper(I) complexes are useful for various applications including photovoltaic cells, light-emitting electrochemical cells, and analyte sensor systems. | 08-28-2008 |
