| WATERS TECHNOLOGIES CORPORATION Patent applications |
| Patent application number | Title | Published |
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| 20120132794 | Apparatus And Components Thereof For Liquid Chromatography - The invention provides chromatographic apparatus and components manufactured from a corrosion resistant alloy typically comprising iron, nickel, chromium and molybdenum. The apparatus and components exhibit superior biocompatibility and corrosion resistance, especially to mobile phases containing chlorides. They are especially useful in HPLC and HPLC, and are particularly useful in conjunction with chromatographic separation media comprising particles smaller than 2 μm diameter. | 05-31-2012 |
| 20120125843 | METHODS AND MATERIALS FOR PERFORMING HYDROPHOBIC INTERACTION CHROMATOGRAPHY - A method for performing hydrophobic interaction chromatography includes providing at least one wall defining a chamber having an inlet and an exit, and a stationary phase disposed within the chamber. The stationary phase comprises particles or monolith having a hydrophobic surface and a hydrophilic ligand. The method also includes loading a sample onto the stationary phase in the chamber and flowing the sample over the stationary phase. The sample is separated into one or more compositions by hydrophobic interaction between the stationary phase and the one or more compositions. | 05-24-2012 |
| 20120119128 | Rotary Shear Injector Valve With Coated Stator Surface - A valve includes a rotor and a stator. The rotor and the stator each have seal surfaces for contacting and sliding against one another during operation of the valve. Either or both of the rotor and the stator have a seal-surface coating formed by depositing an at least partially amorphous interlayer on a substrate and depositing a surface layer, including diamond-like carbon, the interlayer. The surface layer requires no mechanical polishing. | 05-17-2012 |
| 20120103075 | Automated Dilution For Liquid Chromatography - Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced. | 05-03-2012 |
| 20120097026 | Piston Pump With Leak Diagnostic Port - Described are embodiments of a pump having a diagnostic port that enables users and support personnel to diagnose the source of a pump leak. The diagnostic port is monitored visually or with a pressure or liquid detection sensor. In some embodiments, fluid detected at the diagnostic port corresponds to a leak around a circumference defined at an outer sealing surface of a high pressure seal. In other embodiments, fluid detected at the diagnostic port corresponds to a leak around a plunger at the inside diameter of the high pressure seal. Multiple diagnostic ports can be provided to allow separate determinations of leaks about the different portions of the high pressure seal. The embodiments may eliminate the need to disassemble the pump to determine the source of leaks. Thus the effort required to diagnose and repair the pump can be substantially reduced, and fewer misdiagnosed components are ordered or replaced. | 04-26-2012 |
| 20120092664 | OPAQUE ADDITIVE TO BLOCK STRAY LIGHT IN TEFLON.RTM. AF LIGHT-GUIDING FLOWCELLS - The present invention is directed to the use of a light absorbing wall material to eliminate stray light paths in light-guiding structures, such as those used for HPLC absorbance detection. More specifically, the present invention relates to the use of carbon-doped Teflon® AF, or “black Teflon® AF,” for all or part of the walls of a light-guiding flowcell adapted for use in HPLC absorbance detection. | 04-19-2012 |
| 20120055860 | HYBRID INORGANIC/ORGANIC MATERIALS HAVING NOVEL SURFACE MODIFICATION; PROCESS FOR THE PREPARATION OF INORGANIC/ORGANIC HYBRID MATERIALS; AND USE OF SAID PARTICLES FOR CHROMATOGRAPHIC SEPARATIONS - The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The preparation of the inorganic/organic hybrid materials of the invention wherein a surrounding material is condensed on a porous hybrid core material will allow for families of different hybrid packing materials to be prepared from a single core hybrid material. Differences in hydrophobicity, ion-exchange capacity, surface charge or silanol activity of the surrounding material may be used for unique chromatographic separations of small molecules, carbohydrates, antibodies, whole proteins, peptides, and/or DNA. | 03-08-2012 |
| 20120040968 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND - Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein. | 02-16-2012 |
| 20120037724 | Electrospray Interface To A Microfluidic Substrate - An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal. | 02-16-2012 |
| 20120032628 | Intake Profile For Optimized Utilization Of Motor Characteristics - Systems and methods for operating a stepper motor of a pump at a desired low velocity include memory for storing information corresponding to an intake velocity profile. The intake velocity profile represents an optimized acceleration curve for operating the stepper motor over a range of motor velocities during an intake cycle. A processor of a system controller dynamically accesses the memory during the intake cycle to acquire the information representing the intake velocity profile and issues a series of pulses to the stepper motor based on this information. In response to the pulses, the stepper motor accelerates in accordance with the optimized acceleration curve represented by the intake velocity profile. The optimized acceleration curve is based on the available torque of the stepper motor across a range of motor velocities and enables the motor to operate with greater torque utilization and less margin than traditional linear acceleration profiles. | 02-09-2012 |
| 20120024399 | Electrospray Interface To A Microfluidic Substrate - A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate. | 02-02-2012 |
| 20110315633 | Rotating Valve - Described is a rotary valve including a stator element and a rotor element. The stator element defines a first inlet passage, a second inlet passage, and a first outlet passage, respectively, having a first inlet port, second inlet port and first outlet port in a stator face. The rotor element has a rotor face in contact with the stator face and has a first channel and a second channel formed therein. The rotor element is rotatably movable about a rotational axis to at least a first position and a second position. In the first position, the first inlet port is fluidly coupled to the first outlet passage by the first channel and the second inlet port is fluidly coupled to the first outlet passage by the second channel. In the second position, the first inlet port is fluidly coupled to the first outlet passage by the first and second channels. | 12-29-2011 |
| 20110290994 | Methods And Apparatus For Performing Gas And Liquid Mass Spectrometry - Embodiments of the present invention feature devices and methods for performing gas chromatography and liquid chromatography with mass spectrometry. The device and method feature a removable housing which housing contains the gas samples when the mass spectrometry receives gas samples. The device fits an atmospheric pressure ionization housing and upon removal, the atmospheric pressure ionization housing receives liquid samples. | 12-01-2011 |
| 20110278214 | Liquid-Chromatography Conduit Assemblies Having High-Pressure Seals - A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits. | 11-17-2011 |
| 20110272855 | Techniques For Patterning Valve Components - Described are techniques for fabricating one or more parts of a valve used in a liquid chromatography system. At least one of a rotor and a stator are provided. The rotor is included in the valve and has a first surface facing a stator. The stator is included in the valve and has a second surface facing the rotor. A pattern is formed in at least one of the first surface and the second surface. Forming the pattern includes compressing the at least one surface by applying pressure thereto causing displacement of material to form at least one groove. | 11-10-2011 |
| 20110271755 | Apparatus And Methods For The Measurement Of Mass Related Parameters - Embodiments of the present invention are directed to resonating detection devices in which the sample flows through a conduit having a section in which the conduit is grouped or concentrated with the point of maximum movement. | 11-10-2011 |
| 20110269241 | Methods And Kits For The Determining The Presence Or Absence Of Cyanobacteria Toxins - Embodiments of the present invention are directed to kits and methods for the detection of toxins produced by cyanobacteria. The methods and kits feature sample preparation steps with weak cationic and anionic exchange resins and small particle analytical columns operating at 4,000 to 15,000 psi. | 11-03-2011 |
| 20110266434 | Stacked-Electrode Peptide-Fragmentation Device - A chemical processing apparatus includes a fragmentation device that includes a linear set of stacked electrodes and a voltage control module that forms DC potential wells of opposite polarity for mutual confinement of opposite polarity ions. A method of protein analysis includes confining positive peptide ions and negatively charged reagent anions in, respectively, first and second DC potential wells in a fragmentation device, mixing the ions, in the fragmentation device, and analyzing ion fragments formed in the mixture. | 11-03-2011 |
| 20110266433 | Apparatus And Methods For Gas Chromatography - Mass Spectrometry - The invention provides improved apparatus for, and methods of, ionizing analyte molecules in a flow of gas, typically at or around atmospheric pressure. The invention may be used to facilitate mass spectrometric analysis of analytes comprised in the effluent form a gas chromatograph. Ionization may be effected by atmospheric pressure chemical ionization or by atmospheric pressure photo ionization. | 11-03-2011 |
| 20110263033 | Apparatus And Methods For Performing Photoreactions And Analytical Methods And Devices To Detect Photo-Reacting Compounds - Embodiments of the present invention are directed to devices and methods for performing photoreactions of photo-reacting compounds in solution. The invention features a vessel and a light source. The vessel has at least one wall defining a chamber. The chamber, for performing photoreactions, has a chamber volume, a first window, an inlet and an outlet. The inlet and outlet are in fluid communication with a source of photo-reacting compounds in solution. The first window is transparent to light transmission and is placed in optical communication with a light source to receive photons. The chamber is for receiving a solution over time to define a dwell time. The solution potentially has one or more photo-reactive compounds having a concentration. The device further comprises a light source, in optical communication with the first window, for emitting photons which photons are received by the first window and transmitted into the chamber. | 10-27-2011 |
| 20110263029 | Methods And Kits For The Determining The Presence Or Absence Of Ergot Alkaloids - The present invention is directed to methods and kits for the determining the presence or absence of ergot alkaloids in sample which use chromatographic instrumentation and columns operating at a pressure of 4,000 to 15,000 psi and columns with 1-3 micron particle size to produce results by mass spectroscopy in approximately four minutes. | 10-27-2011 |
| 20110261642 | Valve Switch Modulation For Reducing Errors Due Oscillations Of The Inlet Fluid Of A Pump System - Described is a method of reducing liquid composition errors in a low-pressure mixing pump system. Packets representing the switching intervals of each component of the desired fluid mixture are provided to an intake of the mixing pump system. For each packet, a switching time associated with at least one of the components in the packet is modulated. Modulated switching times are based on time offsets that are specifically selected according to the undesirable frequency characteristic of an intake response of the mixing pump system. The average of the volumes contributed by the packets thus modulated is equal to a component volume that achieves a desired proportion of the component in the output flow of the mixing pump system. Modulated switching times enable the reduction or elimination of composition error in the output flow of the mixing pump system. | 10-27-2011 |
| 20110260049 | Method And Apparatus For Identifying Proteins In Mixtures - Protein identification in a complex sample begins by selecting a database having proteins likely to be in the sample. In-silico digestion is performed and a target peptide is selected from produced peptides. The masses of the Y- and B-ion fragments of the target peptide are determined. These masses are used to search previously obtained low- and high-energy AMRTs obtained from LC/MS analysis of the complex sample for masses on the list. Any mass observed in the data within a detection threshold are considered a hit. If enough hits accumulate in a given retention time, the target peptide is identified as being in the sample. The list of peptides identified in the complex sample can be used to identify the proteins present in the sample, track the chromatographic retention times of peptides between samples, and quantitate the peptides and proteins present in complex samples. | 10-27-2011 |
| 20110259827 | Device, Apparatus And Method For Performing Separations - Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly. | 10-27-2011 |
| 20110259089 | Devices Having An Inert Surface And Methods Of Making Same - The present invention features devices and methods of making such devices for performing liquid chromatography having at least one wetted surface having a composition of a polysilazane. | 10-27-2011 |
| 20110247403 | Apparatus And Methods For Multidimensional Analysis - The invention provides improved methods and apparatus for multidimensional analysis, especially for multidimensional liquid chromatography. Methods and apparatus for the quantitative determination of one or more components comprised in a sample mixture are described. Methods and apparatus of the invention typically allow accurate quantitative determination of more components of the mixture than prior multidimensional methods. The invention is particularly useful for, but is not limited to the analysis of complex mixtures of peptides and proteins. | 10-13-2011 |
| 20110226941 | Techniques For Performing Retention-Time Matching Of Precursor And Product Ions And For Constructing Precursor And Product Ion Spectra - Techniques are described for matching a precursor ion with one or more related product ions, including providing a plurality of input data sets obtained from a plurality of injections, each of the plurality of input data sets including a same precursor ion and one or more product ions, normalizing the plurality of input data sets in accordance with a single retention time for the precursor ion, for each of the plurality of input data sets, determining which product ions are within a predetermined retention time window with respect to the single retention time for the precursor ion, and if a product ion is within the predetermined retention time window in at least one of the plurality of input data sets, determining that the product ion is related to the precursor ion having the single retention time | 09-22-2011 |
| 20110202188 | DEVICES, SYSTEMS AND METHODS FOR FLOW-COMPENSATING PUMP-INJECTOR SYNCHRONIZATION - Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream, to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery. | 08-18-2011 |
| 20110198842 | Device And Method For Connecting Fluid Conduits - A connector for connecting a first conduit to a second conduit including a body having a passageway therethrough, a first cavity and a second cavity, a first sealing member, a second sealing member, a first compression, a second compression fitting, a first set of one or more keys and one or more mated key ways for preventing rotation of the first conduit when the first sealing member is compressed, and a second set of one or more keys and one or more mated key ways for preventing rotation of the second conduit when the second sealing member is compressed, wherein each of the first cavity and the second cavity in the body is configured to receive one of the sealing members or a detachable holder configured to receive one of the sealing members. | 08-18-2011 |
| 20110197655 | MULTI-LAYERED CERAMIC MICRO-GAS CHROMATOGRAPH AND METHOD FOR MAKING THE SAME - A micro-gas chromatograph column is formed by texturing a channel into a plurality of green-sheet layers, which are then sintered together to form a substantially monolithic structure. A thick-film paste may be added to the channel textured in the green-sheet layers to provide a porous plug sintered in the micro-gas chromatograph column in the substantially monolithic. A thermal conductivity detector is formed in the substantially monolithic structure by depositing a conductive thick-film paste on the surface of one of the green-sheet layers to define a resistor in an exit channel of the micro-gas chromatograph column. | 08-18-2011 |
| 20110195513 | Methods And Kits For The Determination Of The Presence And Quantity of Vitamin D Analogs In Samples - Embodiments of the present invention are directed to methods and kits for determining the presence or absence, and the amount if present, of vitamin D analogs in samples. One embodiment of the present method for detecting the presence or absence of vitamin D analogs in a sample comprises the steps of adding an effective amount of a multiple charge cationic agent to the sample to form a cationic treated sample. The effective amount of a multiple charge cationic agent enhances the signal from vitamin D analogs upon analysis by mass spectroscopy. | 08-11-2011 |
| 20110141465 | Light-Guiding Flow Cells And Analytical Devices Using The Same - A flow cell for a photometric device includes a module having a body with a distal face defining an annular channel. The body also defines an axial central passage and an axial flow channel. A second module has a body with a proximal face defining an annular channel. The second body also defines an axial flow channel in fluid communication with the first axial flow channel. A light guiding member is within the central passage for exposing a fluid in the flow channels of the modules. An assembly seals an interface between the distal and proximal faces such that the fluid does not leak from the flow channels. The assembly has a metal gasket between the distal and proximal faces, the metal gasket defining a flow path between the flow channels, a first sealing member in the first annular channel and a second sealing member in the second annular channel. | 06-16-2011 |
| 20110134428 | Evaporative Light Scattering Detector - Described is a detector for receiving the eluent from a liquid- or supercritical-fluid chromatograph in which a signal indicative of the presence of an analyte in the eluent is generated by the scattering of light by desolvated particles of the analyte. The detector includes a nebulizer for generating an aerosol from the eluent in a chamber that has a wall in thermal communication with a heat sink. Changes in the temperature of the wall during an analysis of the eluent are reduced by the transfer of heat to the first heat sink. | 06-09-2011 |
| 20110121093 | Apparatus And Methods For Making Analyte Particles - A device for making particulate analyte molecules comprising a nebulizer producing a plume of liquid droplets, a vessel having a chamber to receive the plume in which the chamber has a nebulization section, a desolvation section. The nebulization section is cooled to form a condensed waste from a portion of said plume. The desolvation section is heated to form solvent gas molecules and particulate analyte molecules. | 05-26-2011 |
| 20110107822 | Interfacing With A Digital Microfluidic Device - Described are techniques for use in connection with analyzing a droplet. One or more droplets of a sample are formed on a surface of a digital microfluidic device. The droplets are manipulated to perform processing using said one or more droplets generating one or more resulting droplets. The one or more resulting droplets may be transferred from the microfluidic device to another device for analysis. The one or more droplets may also be provided to the digital microfluidic device from yet another device or analysis instrument. | 05-12-2011 |
| 20110100114 | Thermal Loop Flow Sensor - A flow sensor includes a fluidic component, such as a tube, a heat source, an upstream temperature sensor, and a downstream temperature sensors. The fluidic component defines a flow path having inlet and outlet ends disposed closer to each other than to a mid-point of the flow path. The heat source and the upstream and downstream temperature sensors are disposed in thermal communication with a fluid in the flow path. | 05-05-2011 |
| 20110049056 | COMPOSITE MATERIALS CONTAINING NANOPARTICLES AND THEIR USE IN CHROMATOGRAPHY - Novel porous materials comprising nanoparticles, use in chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material are described by the instant invention. In particular, the disclosure describes porous inorganic/organic hybrid particles embedded with nanoparticles selected from oxides or nitrides of the following: silicon carbide, aluminum, diamond, cerium, carbon black, carbon nanotubes, zirconium, barium, cerium, cobalt, copper, europium, gadolinium, iron, nickel, samarium, silicon, silver, titanium, zinc, boron, and mixtures thereof. | 03-03-2011 |
| 20110044587 | Methods Of making And Using And Apparatus And Devices For Placing Light And Sample In Photo-Emitting Or Absorbing DeviceM - The present invention relates to a device having an optical fiber coupled to a high pressure containment vessel and a method for making the same. The high pressure containment vessel can be an optical fiber based flow cell for a chromatography system. | 02-24-2011 |
| 20110020939 | Chromatography-Based Monitoring and Control of Multiple Process Streams - An analytical apparatus includes a sample-injection valve, a sample pump, at least two sources of standards, and a selection valve. The sample-injection valve has an output port in fluid communication with a LC column, and an input port in fluid communication with a mobile-phase supply line. The at least two sources of standards are associated with at least two pharmaceutical compounds. The selection valve fluidically and selectably connects the sample pump to the at least two sources of standards, to the sample-injection valve, and to at least two pharmaceutical-manufacturing process lines associated with the at least two pharmaceutical compounds. A method for controlling a pharmaceutical manufacturing process includes switching the selection valve to alternately and repeatedly sample the at least two sources of standards and material flowing through the at least two pharmaceutical-manufacturing process lines. | 01-27-2011 |
| 20110016955 | Sample Dilution for Chromatography of Multiple Process Streams - A method of liquid chromatography includes providing an injection valve, drawing a sample and a diluent while mixing, pushing the mixed sample and diluent onto a sample loop of the injection valve, and injecting the mixed sample and diluent. An analytical apparatus includes a proportioning unit, an injection valve having a sample loop, and a sample pump. The injection valve has a draw state and a load state, and has a port in fluidic communication with an outlet port of the proportioning unit. The sample pump is in fluidic communication with the outlet port of the proportioning unit, if the injection valve is in the draw state, to draw both a sample and a diluent through the proportioning unit and the injection valve, and in fluidic communication with the sample loop, if the injection valve is in the load state, to push the drawn sample and diluent onto the sample loop. | 01-27-2011 |
| 20100324159 | NOVEL ION EXCHANGE POROUS RESINS FOR SOLID PHASE EXTRACTION AND CHROMATOGRAPHY - Embodiments of the present invention are directed to porous resins for solid phase extractions. The resins feature at least one hydrophobic component, at least one hydrophilic component and at least one ion exchange functional group. The resins exhibit superior wetting and ion exchange performance. | 12-23-2010 |
| 20100322281 | Large Array Defferential Scanning Calorimeter, DSC Measuring Unit - Embodiments of the present invention feature a method and apparatus for an energetics-based approach to screen and to characterize binding interactions between potential therapeutic (or diagnostic) agents and unknown target molecules. The methods and apparatus detect the occurrence of these reactions, the strength of the binding interaction and possibly the rate at which these processes take place. | 12-23-2010 |
| 20100320374 | DEVICES AND METHODS FOR PERFORMING MASS ANALYSIS - Embodiments of the present invention feature devices and methods for performing mass analysis. One embodiment of the device comprises an inlet housing for mounting on the first wall between the area of low pressure and the area of high pressure. The inlet housing has passages and restrictions which can be adjusted with respect to a sample plume or changed by substituting alternative inlet housings. | 12-23-2010 |
| 20100307226 | APPARATUS, KITS AND METHODS FOR DETERMINING THE PRESENCE OR ABSENCE OF MINERALOCORTICOIDS IN SAMPLES - Embodiments of the present invention feature apparatus, kits and methods for detecting the presence or absence of a mineralocorticoid in biological samples. The methods, apparatus and kits feature a high performance liquid chromatography system with a column for receiving one or more biological samples potentially having mineralocorticoid, said chromatography system receiving one or more biological samples at a first time and separating the compounds in retained peaks comprising at least mineral corticoid retained peak for a mineralocorticoid in the event said mineralocorticoid is present at a mineralocorticoid retention time. And, a mass spectrometer in fluid communication with the high performance liquid chromatography system receives one or more of said retained peaks including the mineralocorticoid retained peak at the mineralocorticoid retention time, and produces a signal to allow said mineralocorticoid to be identified by retention peak and mass charge values. | 12-09-2010 |
| 20100300972 | POROUS MATERIALS FOR SOLID PHASE EXTRACTION AND CHROMATOGRAPHY AND PROCESSES FOR PREPARATION AND USE THEREOF - Embodiments of the present invention are directed to porous materials for use in solid phase extractions and chromatography. The materials feature at least one hydrophobic component, at least one hydrophilic component and at least one ion-exchange functional group. The materials exhibit superior wetting and ion-exchange performance. | 12-02-2010 |
| 20100285596 | METHODS FOR ISOLATING FUNCTIONALIZED MACROMOLECULES - The invention provides methods of isolating, purifying, analyzing and/or detecting, functionalized macromolecules, e.g., peptides, phosphopeptides, polypeptides, proteins, oligonucleotides, or phospholipids in a sample, e.g., a biological mixture, using solid phase extraction with an alumina sorbent packed in a micro-elution plate. | 11-11-2010 |
| 20100285593 | INTERNAL STANDARDS AND METHODS FOR USE IN QUANTITATIVELY MEASURING ANALYTES IN A SAMPLE - The invention provides methods for quantitatively analyzing a plurality of analytes in a sample. Also described are general and specific internal standards useful in such analysis. In particular embodiments, these standards are described as useful in liquid chromatography/mass spectroscopy systems, which are also described herein. Moreover, in certain embodiments, the quantification methods of the present invention are useful in increasing the precision and/or accuracy of multiple analyte quantification for analytes contained in a single sample mixture using known analyte derivatives simultaneously analyzed, and compared to the unknown analytes. | 11-11-2010 |
| 20100278695 | Chromatographic And Electrophoretic Separation Media And Apparatus - The invention provides improved separation media for use in chromatography and electrophoresis, or for the selective absorption of certain components of a sample mixture, especially in a preliminary stage of an analysis. Improved media according to the invention comprises first particles capable or retaining one or more of the components of a sample mixture and second particles selected to have a higher thermal conductivity than the first particles, so that the thermal conductivity of the media is higher than that of media comprising the first particles alone. The media may be incorporated in packed or capillary columns for chromatography (especially nanoflow HPLC) or for capillary electrophoresis, or may be coated on a substrate. Particular embodiments of the media may comprise mixtures of first particles comprising siliceous polymers, second particles of gold, diamond or graphite. Chromatographic columns and apparatus incorporating them are also disclosed. | 11-04-2010 |
| 20100278210 | SIMULTANEOUS DIFFERENTIAL THERMAL ANALYSIS SYSTEM - A balance for a simultaneous differential thermal analysis instrument that combines gravimetric measurements with measurements that require propagation of electrical signals from the sample holder to an apparatus for recording the electrical signals. In one embodiment of the present invention, conductive cross-flexure pivots are used in a parallel guided balance to mechanically and electrically couple the components of the balance mechanism to the apparatus that records the electrical signals. | 11-04-2010 |
| 20100278209 | SIMULTANEOUS DIFFERENTIAL THERMAL ANALYSIS SYSTEM - A balance for a simultaneous differential thermal analysis instrument that combines gravimetric measurements with measurements that require propagation of electrical signals from the sample holder to an apparatus for recording the electrical signals. In one embodiment of the invention, conductive flat planar strip flexure pivots are used in a single-meter movement balance to mechanically and electrically couple the components of the balance mechanism to the apparatus that records the electrical signals. | 11-04-2010 |
| 20100202897 | HIGH PRESSURE PUMP CONTROL - A feedback control loop for a high pressure pump modifies the accumulator velocity and pressure during solvent transfer. The accumulator velocity is adjusted to maintain the system pressure equal to the expected pressure to thereby eliminate the effect of the flow deficit created by a thermal effect. | 08-12-2010 |
| 20100189574 | HIGH PRESSURE PUMP CONTROL - A feedback control loop for a high pressure pump modifies the accumulator velocity and pressure during solvent transfer. The accumulator velocity is adjusted to maintain the system pressure equal to the expected pressure to thereby eliminate the effect of the flow deficit created by a thermal effect. | 07-29-2010 |
| 20100187414 | Apparatus And Method For Identifying Peaks In Liquid Chromatography/Mass Spectrometry Data And For Forming Spectra And Chromatograms - Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix. Parameters of the peaks are determined and stored for later processing including quantitation, or simplification of chromatograms or spectra by, for example, identifying peaks associating with ions having retention times falling within a specified retention time window or having mass-to-charge ratios falling within a specified mass-to-charge ratio window. | 07-29-2010 |
| 20100178663 | Apparatus And Methods For The Detection Of Plasma Metanephrines - Embodiments of the present invention feature the determination of normetanephrine, metanephrine and 3-methoxytyraminein raw human plasma with minimal sample pretreatment using a weak cationic extraction media to provide a selective sample clean-up and HILIC chemistries as indicators of pheochromoacytoma. | 07-15-2010 |
| 20100176043 | MOBILE PHASE DILUTION SCHEME FOR ENHANCED CHROMATOGRAPHY - A method and device for increasing the loading capacity of a chromatography column through dilution of a mobile phase at the head of the column. A strong mobile phase is provided for dissolving a sample. A sample is injected into the strong mobile phase, and subsequently diluted with a weak mobile phase. The resulting sample-containing weak mobile phase is passed through a chromatography column for retention and separation of the components of the sample. | 07-15-2010 |
| 20100168457 | MONOLITHIC ELECTROKINETIC PUMP FABRICATION - High-pressure electrokinetic (“EK”) pumps comprising a hybrid monolith provide a high surface charge density and a continuous stable skeleton morphology with micrometer- sized through-pores. The hybrid monolith of the subject invention has superior mechanical strength and better stability in comparison to prior art monoliths with equivalent mechanical stability. The surface charge of the hybrid monolith can be modified and/or made stable by the use of different chemical reagents. The chemical reagents and resulting modification to the monolith serves to expand the usefulness of the hybrid monolith to a variety of pumping applications including chip-based systems and other applications where the ability to pump an acidic solution is required. | 07-01-2010 |
| 20100158704 | COMPLIANT-SEAL CHECK VALVE - A check valve includes a valve seat and a compliant member that moves to seal the check valve by contacting the valve seat. A method for priming a chromatography solvent pump includes providing the check valve in fluid communication with an outlet of the pump, drawing fluid into the pump from a fluid source, and expelling the fluid from the pump through the valve, thus wetting the check valve. Another method for priming a chromatography solvent pump includes providing the check valve in fluid communication with an inlet of the pump, drawing fluid through the valve into the pump, and expelling the fluid from the pump. | 06-24-2010 |
| 20100148057 | Device And Method For Analyzing A Sample - Embodiments of the invention relate to a device for analysing a sample surface Comprising an outlet and a frame. The outlet is for forming a jet of gas, the jet forming a sampling region for receiving one or more sample surfaces, and the frame holding the outlet and being adapted to receive a detector means. The detector means has an inlet. In use, the jet produces desorbed sample from sample surfaces received in the sample area. At least a portion of the desorbed sample is ionized to produce one or more sample ions. The frame holds the outlet with respect to the sample ions and produce a signal indicative of the composition of the sample ions. | 06-17-2010 |
| 20100133431 | Device, Apparatus And Methods For Mass Spectrometry - The invention comprises apparatus for use with atmospheric pressure ionization sources in which an aerosol is formed from a solution of a sample. The aerosol is received in a hollow member and discharged outside the chamber of the ionization source in order to reduce contamination of the ionization source itself by involatile material in the solution and by previously analysed samples. The hollow member is easily removable from the ionization source to facilitate cleaning and replacement. Ionization sources, mass spectrometers, and ion mobility spectrometers comprising the apparatus are also described. | 06-03-2010 |
| 20100132799 | Vessel, Dispensing Devices, Kits And Methods For Containing Fluids - A device for limiting sample evaporation. The device has a vessel body having a body exterior surface and at least one body interior surface. The at least one body interior surface has one or more walls defining a first chamber, a second chamber and a conduit means. The first chamber has a first chamber opening for receiving at least one of the groups selected from a sample and a sample dispensing device. The first chamber opening defines the border of the body exterior surface and the body interior surface. The conduit means is in communication with the first chamber and the second chamber for receiving at least one of the group consisting of sample from said first chamber, a sample from a sample dispensing device and a sample dispensing device passing through or into the conduit means for placing the sample in the conduit means or into the second chamber. The second chamber is in communication with the conduit means for receiving and containing the sample from at least one of the group selected from the sample dispensing device and conduit means. The conduit means is arranged such that the sample in the second chamber is substantially isolated from the atmosphere to limit sample evaporation in the second chamber as the sample is contained therein. | 06-03-2010 |
| 20100116745 | Closed Loop Flow Control Of A HPLC Constant Flow Pump To Enable Low-Flow Operation - A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (<0.1 mL/min) and nano-scale (<1 μL/min) HPLC flow rates. | 05-13-2010 |
| 20100108164 | DEFINED LEAK PATH FOR HIGH PRESSURE SEAL - Embodiments of the present invention are directed to methods and devices for conveying or containing fluids under pressure in which seals are provided with a defined path to vent fluid in the event of a seal failure. | 05-06-2010 |
| 20100107742 | APPARATUS AND METHODS OF FLUID CHROMATOGRAPHY - The invention provides improved methods and apparatus for fluid chromatography, and is particularly appropriate to high-pressure liquid chromatography carried out using eluent flow rates less than 1 μl/minute, for example on nanoflow columns. In both single- and multi-dimensional chromatography systems, especially those comprising trapping media to facilitate injection of relatively large volumes of sample on to nanoflow columns, the on-line addition of a diluting solvent enables stronger eluents and sample solvents to be employed without causing premature release of analytes from the trapping media or the degradation of the second dimension chromatographic separation. The invention may be advantageously used for two-dimension reverse phase/reverse phase separations, especially for the separation of complex mixtures of peptides. | 05-06-2010 |
| 20100065495 | APPARATUS AND METHODS FOR PREPARATIVE LIQUID CHROMATOGRAPHY - A method of liquid chromatography includes providing one or more solvent reservoirs, providing a solvent pump, drawing one or more solvents into the pump in response to a pressure drop that promotes outgassing of the solvents, and dispersing outgassed bubbles into smaller bubbles to promote re-dissolution of the gas. A liquid-chromatography apparatus includes at least two solvent reservoirs, a pump, at least one bubble-dispersing unit that receives a pressurized flow of proportioned solvents from the pump, and a control unit. The control unit includes a processor and a memory that stores instructions; the control unit controls proportioning of solvents to obtain a preselected solvent composition, and pumping at flow rates to support preparative-scale or process-scale liquid chromatography. | 03-18-2010 |
| 20100065492 | Compositions And Methods For Separating Enantiomers - A liquid chromatography system comprising a chiral mobile phase used to separate enantiomeric molecules present in a sample is disclosed herein. In one aspect, the mobile phase comprises a chiral solvent. In another aspect, the mobile phase includes a chiral solvent but also a buffering agent. The liquid chromatography system described herein includes both high pressure liquid chromatography (HPLC) as well as high pressure capillary liquid chromatography (CapLC). | 03-18-2010 |
| 20100065141 | TUBING AND METHOD FOR MANUFACTURE - An apparatus for conveying fluid comprising a first tube and a second tube. The first tube has a first end and a second end, an inner wall and an outer wall. The inner wall defines a passage for fluid and an outer wall has at least one first receiving section for receiving an inner wail from the second tube. The second tube has a first end and a second end, an inner wall and an outer wall. The inner wall defines a chamber for receiving the first tube and has at least one second receiving section for receiving the outer wall of the first tube wherein at least one of the first tube and the second tube are drawn down such that the first receiving section and the second receiving section of the first tube and the second tube are in close proximity to each other and sealed. | 03-18-2010 |
