| WATERS INVESTMENTS LIMITED Patent applications |
| Patent application number | Title | Published |
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| 20110184648 | METHODS AND APPARATUS FOR PERFORMING RETENTION-TIME MATCHING - A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module. | 07-28-2011 |
| 20100280811 | BASELINE MODELING IN CHROMATOGRAPHY - An apparatus and a method of chemical analysis entail acquiring a chromatogram, median filtering the chromatogram to produce a model baseline, smoothing the model baseline to reduce noise, and subtracting the smoothed model baseline from the acquired chromatogram to produce a modified chromatogram having a substantially flat baseline. | 11-04-2010 |
| 20100267939 | DEVICE AND METHODS FOR PREPARATION OF PEPTIDES AND PROTEINS SAMPLES FROM SOLUTION - Featured are devices, methods and kits for preparation of samples of peptides and proteins from a solution; more particularly to such devices and methods in which carbon nanotubes are utilized for sample preparation and/or purification of peptide and/or protein samples from a solution. A sample to be treated/processed can comprise proteins, peptides or any other molecule having an amine moiety that can be protonated under low pH, such as, but not limited to, pH 5. Such a sample also can contain contaminants such as salts, detergents, etc. that will be eliminated during the sample preparation/purification process of the present invention. The methods, devices and kits of the present invention advantageously provide for the concentration of the sample, removal of contaminants and ease of manipulation of small liquids without the concomitant loss of sample. | 10-21-2010 |
| 20100230954 | HIGH-PRESSURE TUBING - A method for making conduits includes inserting an inner tube into an outer tube and melting a portion of the inner tube to form a bond with the outer tube. The inner tube includes a polymeric material and the outer tube includes a material having a greater yield strength than the polymeric material. A conduit includes one or more inner tubes at least one of which is melt-bonded to one or more outer tubes. An analytical instrument includes a separation column, a solvent reservoir and pump, a sample injector, a detector to observe an eluent of the separation column, and tubing to transport fluid between components of the instrument. | 09-16-2010 |
| 20100154439 | COOLING SYSTEM USING POSITIVE DISPLACEMENT CRYOGENIC LIQUID PUMP - A cooling system employs a single-acting positive displacement bellows pump to transfer a cryogenic liquid such as liquid nitrogen from a storage dewar to a heat exchanger coupled to a measurement chamber of an instrument, wherein cooling takes place by vaporizing the liquid. Preferably, the capacity of the pump is greater than the maximum cooling requirement of the instrument, wherein both vapor resulting from vaporizing of the cryogenic liquid circulated through the heat exchanger and liquid that does not vaporize when circulated through the heat exchanger are returned to the storage dewar, wherein the vapor is subsequently vented from the dewar. Preferably, with the aid of a weir in a return line, the level of liquid in the heat exchanger is maintained full and constant, and the cooling demands are automatically met without the need for other control of the flow rate or level of the liquid. Also, unlike conventional systems, liquid transfer from the dewar does not require dewar pressurization, so that the dewar may be refilled whenever necessary without interrupting the experiment in progress. | 06-24-2010 |
| 20100076103 | POROUS CARBON-HETEROATOM-SILICON HYBRID INORGANIC/ORGANIC MATERIALS FOR CHROMATOGRAPHIC SEPARATIONS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides porous carbon-heteroatom-silicon inorganic/organic homogenous copolymeric hybrid materials, methods for their preparation, and uses thereof, e.g., as chromatographic separations materials. | 03-25-2010 |
| 20100043539 | DEVICE AND METHODS FOR REDUCING PRESSURE AND FLOW PERTURBATIONS IN A CHROMATOGRAPHIC SYSTEM - Embodiments of the present invention are directed to methods and apparatus for placing a sample in a chromatographic system. The device and method feature placing samples held in a sample loop to pressurization prior to placing such sample loop in communication with high pressure conduits. | 02-25-2010 |
| 20100026999 | METHODS OF MAKING AND USING AND APPARATUS AND DEVICES FOR PLACING LIGHT AND SAMPLE IN PHOTO-EMITTING OR ABSORBING DEVICES - The present invention relates to apparatus and devices ( | 02-04-2010 |
| 20100024906 | PUMP - Embodiments of the present invention are directed to devices and methods for propelling fluids that feature at least one first pump assembly having a primary pump, an accumulator pump, drive means, valve means and control means. The valve means moves between the first position and the second position as the accumulator pump and primary pump alternate between a loading movement and a pump movement. The control means is in signal communication with the accumulator pump, the primary pump and the valve means. The control means issues signal command to the accumulator pump to assume the loading movement and the pump movement and the primary pump to assume the loading movement and pump movement in coordination with the movement of the valve means such that fluids are propelled from the first outlet. | 02-04-2010 |
| 20100018928 | DEVICE FOR PERFORMING SEPARATIONS AND METHODS OF MAKING AND USING SAME - Embodiments of the present invention feature a device ( | 01-28-2010 |
| 20100012192 | ACTIVE VALVE AND METHODS OF OPERATION THEREOF - A valve including a linear positioning component operatively connected to a valve body and an actuating element. | 01-21-2010 |
| 20090321356 | CERAMIC-BASED CHROMATOGRAPHY APPARATUS AND METHODS FOR MAKING SAME - A high-performance liquid-chromatography apparatus includes a substrate that defines a separation column in fluidic communication with an inlet port of the processing unit. The processing unit is formed of sintered inorganic particles. The apparatus also includes a pump that delivers a solvent to the inlet port at a pressure sufficient for high-performance liquid-chromatography. | 12-31-2009 |
| 20090317791 | Methods and apparatus for performing retention-time matching | 12-24-2009 |
| 20090306901 | SYSTEM AND METHOD FOR ABSOLUTE QUANTITATION OF PROTEINS USING LC/MS - Absolute quantitation of protein in a sample is provided by comparing a sum or average of the N highest ionization intensities observed for peptides of a particular protein along with a calibration standard. The calibration standard can be in the form of a table generated by prior protein peptide analysis performed using one or more pre-determined proteins. The comparison is used to determine a corresponding absolute quantity of protein based on the observed sum or average of ionization intensities. A simple conversion factor can be applied to the calibration standard value to determine the absolute quantity of protein in the sample. | 12-10-2009 |
| 20090294645 | ION DETECTION AND PARAMETER ESTIMATION FOR N-DIMENSIONAL DATA - Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data. | 12-03-2009 |
| 20090294363 | METHODS AND APPARATUS FOR GENERATING SOLVENT GRADIENTS IN LIQUID CHROMATOGRAPHY - Embodiments of the present invention feature methods and apparatus for performing chromatographic separations. The invention feature methods and control means in the form of computer programs and software that control the formation of a concentration gradient at two or more total flow rates, with an elution period occurring in a slow flow rate and at least other portions of the gradient occurring during a fast total flow rate. | 12-03-2009 |
| 20090294344 | Fluid mixer assembly - Disclosed is an assembly for mixing fluids (i.e., gases or liquids), and more particularly an assembly that accurately mixes two or more high-pressure fluid sources and is adapted for use in applications, such as for example, chromatography. The mixer assembly includes, inter alia, a housing, an inlet fitting, and a mixer cartridge assembly. The housing has a fluid receiving section and a fluid discharge section with a fluid outlet formed therein. A central bore extends between the fluid receiving section and fluid discharge section. An inlet fitting is engaged with the housing and has first and second fluid inlet ports formed therein that extend from the fitting exterior to the fluid receiving section of the housing. A mixer cartridge assembly is disposed within the central bore of the housing and is positioned between the inlet fitting and the downstream end portion of the housing. The mixer cartridge assembly includes a body portion, a plurality of spheres disposed within a central mixing chamber formed in the body portion, and mechanism for retaining the spheres in the mixing chamber. | 12-03-2009 |
| 20090269859 | Mobile Bead Configuration Immunoaffinity Column and Methods of Use - It has been discovered that a column configuration which allows for suspension of the beads, such as a mobile bead, during washing results in significantly lower levels of background and hence more sensitive levels of quantitation. The present invention provides columns, kits, and methods for more sensitive detection of a toxin or other analyte. | 10-29-2009 |
| 20090224148 | APPARATUS AND METHOD FOR PERFORMING MASS SPECTROSCOPY - Embodiments of the present invention are directed to apparatus and methods for performing mass spectrometry. Data pair information is subjected to an ion audit process in which data pair information that relates to scored compounds is subtracted from the data pair information. The depleted information more readily reveals data pair information for compounds present with smaller signals. | 09-10-2009 |
| 20090215103 | GENERATION AND USE OF A CATALOG OF POLYPEPTIDE-RELATED INFORMATION FOR CHEMICAL ANALYSES | 08-27-2009 |
| 20090211978 | Passive column pre-heater with sample band spreading reduction feature - Disclosed is a chromatographic system and method which includes a passive pre-heater assembly. In the inventive system and method a fluid mixture is supplied from an injector to the pre-heater assembly and then to a chromatographic column having an active heating source. The pre-heater assembly includes a convoluted tube with first and second ends and a fluid passage extending centrally therebetween, first and second end fittings attached respectively to the first and second ends of the convoluted tube, and a thermally conductive film attached to an outer surface of the convoluted tube. The first end fitting is adapted for fluidly connecting the first end of the convoluted tube to the injector and the second end fitting is adapted for fluidly connecting the second end of the convoluted tube to the chromatographic column. The thermally conductive film conveys heat from an active heating source of a chromatographic column to the convoluted tube when the pre-heater assembly is positioned adjacent to the active heating source. The central fluid passage in the convoluted tube has a series of bends which function to create a secondary fluid flow field that is substantially orthogonal to a primary flow field established when fluid is traversing the fluid passage in the tube. | 08-27-2009 |
| 20090209722 | POROUS INORGANIC/ORGANIC HOMOGENOUS COPOLYMERIC HYBRID MATERIALS FOR CHROMATOGRAPHIC SEPARATION AND PROCESS FOR THE PREPARATION THEREOF - The present invention relates to porous inorganic/organic homogenous copolymeric hybrid material materials, including particulates and monoliths, methods for their manufacture, and uses thereof, e.g., as chromatographic separations materials. | 08-20-2009 |
| 20090205409 | SOLVENT DELIVERY SYSTEM FOR LIQUID CHROMATOGRAPHY THAT MAINTAINS FLUID INTEGRITY AND PRE-FORMS GRADIENTS - A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp. | 08-20-2009 |
| 20090175766 | VISUALIZATION OF CHEMICAL-ANALYSIS DATA - A method includes compressing chemical-analysis data points with no loss of information, generating, from the stored data points, nested data arrays, storing the nested data arrays in a video memory, rendering an image from the nested data arrays, and displaying the rendered image. A chemical-analysis instrument includes a chromatography module, a mass-spectrometry module that receives an eluent from the chromatography module, a computer unit that receives data points from the chromatography and mass-spectrometry modules, and a monitor for displaying rendered images. | 07-09-2009 |
| 20090159751 | DEVICES AND METHODS FOR PREVENTING ICE BUILD-UP AND ARTICLES OF MANUFACTURE THAT ARE RESISTANT TO ICE BUILD-UP - Embodiments of the present invention feature heat exchange surfaces having a layer or coating having a lower surface tension than water, to repel water and prevent the formation of condensate on said surface. | 06-25-2009 |
| 20090139323 | NOVEL ION EXCHANGE POROUS RESINS FOR SOLID PHASE EXTRACTION AND CHROMATOGRAPHY - Embodiments of the present invention are directed to porous resins for solid phase extractions. The resins feature at least one hydrophobic component, at least one hydrophilic component and at least one ion exchange functional group. The resins exhibit superior wetting and ion exchange performance. | 06-04-2009 |
| 20090127177 | POROUS INORGANIC/ORGANIC HYBRID PARTICLES FOR CHROMATOGRAPHIC SEPARATIONS AND PROCESS FOR THEIR PREPARATION - Novel material for chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material. In particular, the disclosure describes porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry, which desirably may be surface modified, and that offer more efficient chromatographic separations than that known in the art. | 05-21-2009 |
| 20090122315 | EVAPORATIVE LIGHT SCATTERING DEVICE AND METHODS OF USE THEREOF - Apparatus for the detection of analytes in a fluid, for example the eluant from a liquid chromatography is described. Solvent is evaporated from the eluant to produce a stream of particles when analyte is present in the fluid. The resultant stream of particles is passed through one or more beams of radiation, typically visible light, and radiation scattered by the particles is detected at least at a first angle to a beam of radiation and at a second, different, angle to a radiation beam to produce a signal indicative of the presence of the analyte. | 05-14-2009 |
| 20090062966 | DEVICES, SYSTEMS AND METHODS FOR FLOW-COMPENSATING PUMP-INJECTOR SYNCHRONIZATION - Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream ( | 03-05-2009 |
| 20090056423 | SYSTEM AND METHOD FOR INTERFACIAL RHEOMETRY - An apparatus and method for performing rheological measurements of interfaces located at the top of fluid sub-phases. In one configuration, a rotating rheometer is provided with a chamber wall whose inner surface defines an outer chamber radius and an inner cylinder disposed within the cylindrical chamber and having an inner chamber radius. The rotating rheometer is configured to hold a liquid sub-phase and interface layer that can be probed using a circular ribbon that is concentric with and suspended between the inner cylinder and chamber wall. The ratio of the ribbon radius, inner chamber radius, and outer chamber radius is designed to yield an average shear rate in the inner region that is the same as an average shear rate in the outer region. In one configuration, an interface-pinning feature is provided on at least one of the inner cylinder and the chamber wall. | 03-05-2009 |
| 20090050212 | METHOD AND APPARATUS FOR SAMPLE INJECTION IN LIQUID CHROMATOGRAPHY - The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure. | 02-26-2009 |
| 20090039024 | APPARATUS AND METHODS FOR PERFORMING STEPS OF A MULTI-STEP PROCESS IN PARALLEL - Embodiments of the present invention feature a device ( | 02-12-2009 |
| 20090035786 | MULTI-ANALYTE AFFINITY COLUMN - A multi-analyte column is disclosed. The column may contain at least one unit of resin having ochratoxin specific affinity and, for each unit of resin having ochratoxin specific affinity, the column further contains about 0.95 to 1.05 units of resin containing antibody having specificity for zearalenone, about 1.9 to 2.1 units of resin containing antibody having specificity for aflatoxin, about 2.35 to 2.65 units of resin containing antibody having specificity for fumonisin, about 2.8 to 3.2 units of resin containing antibody having specificity for T-2 (and/or HT-2) and about 4.7 to 5.3 units of resin containing antibody having specificity for deoxynivalenol. One unit of resin is the quantity of resin containing antibody that will bind 50 ng of aflatoxin, 500 ng of deoxynivalenol, 3300 ng of fumonisin, 50 ng of ochratoxin, 830 ng T-2 (and/or HT-2) or 1140 ng of zearalenone, respectively. | 02-05-2009 |
| 20090027671 | EVAPORATIVE LIGHT SCATTERING DETECTOR - Embodiments of the present invention are directed to evaporation light scattering detectors having an evaporative chamber having a wall that is in good thermal contact with a heat sink. The heat has a high thermal mass such that a change in temperature of the wall during an analysis is minimized. | 01-29-2009 |
| 20090009758 | OPAQUE ADDITIVE TO BLOCK STRAY LIGHT IN TEFLON AF LIGHT-GUIDING FLOWCELLS - The present invention is directed to the use of a light absorbing wall material to eliminate stray light paths in light-guiding structures, such as those used for HPLC absorbance detection. More specifically, the present invention relates to the use of carbon-doped Teflon® AF, or “black Teflon® AF,” for all or part of the walls of a light-guiding flowcell adapted for use in HPLC absorbance detection. | 01-08-2009 |
| 20090008569 | High speed combination multi-mode ionization source for mass spectrometers - The present invention combines ionization modes produced by, for example, electrospray (ESI), atmospheric pressure chemical ionization (APCI), and thermospray for analysis of molecules. Specifically, this invention relates to the creation of a new source apparatus combining APCI and ESI which will interface with existing mass spectrometers, as well as the creation of new mass spectrometers where the present invention would be the ionization source. Furthermore, the present invention relates to an ionization source for a mass spectrometer which features an ion chamber defining an ion path, an electrospray probe for ionizing a sample using electrospray ionization, a corona discharge needle for ionizing a sample using atmospheric pressure chemical ionization, a power supply for applying an electrical potential to one of said electrospray probe and said corona discharge needle, and a solid state switch for directing the electrical potential from the power supply to one of the electrospray probe and said corona discharge needle. | 01-08-2009 |
| 20090000405 | Fluid analysis apparatus - A fluid analysis apparatus for containing and analyzing a fluid sample includes a cell body assembly having a plurality of distinct portions in fluid communication with one another and with the distinct portions being hydraulically sealed to one another through the use of one or more resilient gaskets interposed between adjacent ones of the plurality of distinct portions of the cell body assembly. The one or more resilient gaskets enable both hydraulic sealing of adjacent distinct portions, as well as fluid coupling and routing through the fluid analysis apparatus. | 01-01-2009 |
| 20080314812 | Apparatus and Methods for Cooling Samples - Embodiments of the present invention are directed to apparatus and methods for performing separations of compounds held in a solution. Embodiments of the present invention allow detectors to operate at constant reproducible temperatures that are lower than the temperature of fluids exiting separation devices. An apparatus of the present invention has pump means, fluid conveying means, sample injection means, separation means and heat dissipation means. The heat dissipation means is in fluid communication with the separation means for receiving the fluid and removing thermal energy. | 12-25-2008 |
| 20080309076 | Device and Method for a Fluid-Tight Connection - A device for connecting a fluid conduit to an orifice of a vessel includes a flexible fitting, a deformable fitting, and one or more compression fittings. The flexible fitting can fix a position of the fluid conduit with respect to the orifice of the vessel, and the deformable fitting can provide a fluid seal between the fluid conduit and the orifice of the vessel. A method for connecting a fluid conduit to an orifice of a vessel includes urging a deformable fitting against both a surface of the fluid conduit and the orifice, urging a flexible fitting toward a surface of the fluid conduit, and attaching the flexible fitting to the orifice. | 12-18-2008 |
| 20080305555 | Methods, Compositions and Devices For Performing Ionization Desorption on Silicon Derivatives - A device for the presentation of samples for MALDI or DIOS ion source, comprising a semiconductor wafer body having at least one first surface and at least one second surface, the first surface being chemically modified to repel said aqueous sample toward said second surface. | 12-11-2008 |
| 20080304542 | INFRARED HEATED DIFFERENTIAL SCANNING CALORIMETER - A heat flux differential scanning calorimeter (DSC) is disclosed. The DSC can be configured with a highly conductive sample assembly enclosure. The enclosure can include a high emissivity coating. In one embodiment, the enclosure extends along a longitudinal direction that is about the same as that of an infrared lamp assembly used to heat the enclosure, thereby increasing the efficiency of heating the sample enclosure. In one embodiment, a gas-filled thermal resistor is used to couple the measurement assembly to a heat sink, such that samples can be rapidly heated and rapidly cooled. | 12-11-2008 |
| 20080304540 | SYSTEM AND METHOD FOR THERMAL ANALYSIS USING VARIABLE THERMAL RESISTANCE - A thermal measurement apparatus and method for performing heat flux differential scanning calorimetry (DSC) is disclosed. A variable thermal resistor is used to couple a measurement assembly to a heat sink in the thermal measurement apparatus, such that samples can be rapidly heated and rapidly cooled. The apparatus can be configured with a highly conductive sample assembly enclosure. The enclosure can include a high emissivity coating. In one embodiment, the enclosure extends along a longitudinal direction that is about the same as that of an infrared lamp assembly used to heat the enclosure, thereby increasing the efficiency of heating the sample enclosure. In one configuration, the variable thermal resistor comprises a gap whose gas composition can be varied during a sample measurement to independently optimize sample heating and cooling rates. | 12-11-2008 |
| 20080302423 | Temperature-Controlled Variable Fluidic Resistance Device - A thermally controlled variable restrictor device provides variable restriction of fluid flow by temperature-induced viscosity changes. The thermally controlled variable restrictor device allows fast variable fluid control by employing a thermo-electric heater-cooler in intimate contact with a fluid channel containing a fluid thereby effecting rapid viscosity changes in the flowing fluid. The permeability and flow rate of fluids through the variable restrictor device can be manipulated by changing the temperature of a restriction element. | 12-11-2008 |
| 20080296492 | METHODS AND APPARATUS FOR PERFORMING CHROMATOGRAPHY AND MASS SPECTROSCOPY WITH SUPERCRITICAL FLUID SAMPLES - Embodiments of the present invention are directed to devices and methods for receiving NSC Fluids having at least one analyte from a chromatograph and directing analyte ions into the vacuum regions of a mass spectrometer. The device has a housing having at least one wall defining a chamber, sample inlet, an ionization media inlet and an outlet. The sample inlet has a position in communication with a chromatograph receiving a NSC Fluid. The sample inlet receives the NSC Fluid and directs the NSC Fluid into the chamber to form a sample jet of NSC Fluid. The ionization media inlet is placed in fluid communication with a source of ionization media and directs the ionization media into the chamber and the sample jet to create analyte ions. The analyte ions are received in the mass spectrometer vacuum region orifice. | 12-04-2008 |
| 20080290309 | Pin Valve Assembly - A pin valve assembly and a method of controlling the flow of fluids comprising a pin block housing pin valves, a fluid plate with a fluid channel for fluidically communicating with the pin valves, and a fitting block housing fittings for fluidic communication with the fluid plate and for fluidic communication with fluidic components. The fluid flow through the channels of the fluid plate are controlled by the fluidic components and the pin valves. | 11-27-2008 |
| 20080283739 | Apparatus and Methods for Mass-Spectrometric Directed Purification of Biopolymers - A method for extracting at least one target compound from a sample includes injecting an overloaded amount of the sample into a chromatographic conduit ( | 11-20-2008 |
| 20080283134 | Variable Resistance Fluid Controller - A fluid controller apparatus controls fluid flow, such as a solvent gradient flow, in a chromatography system. An apparatus includes a fluid-gradient controller having a fluid reservoir for containing a pump fluid and a pumping device connected to the fluid reservoir for receiving the pump fluid. The pumping device is in fluid communication with parallel-configured first and second solvent lines. The first and second solvent lines each contain a restrictor element and a solvent reservoir. During operation, the pumping device causes the pump fluid to flow through the first and second solvent lines in relation to their respective restriction devices. The pump fluid displaces solvent within the solvent reservoirs. The displaced solvent is mixed to form a solvent gradient. | 11-20-2008 |
| 20080277574 | Apparatus and Method For Positioning a Discharge Tube With Respect to an Orifice - Embodiments of the present invention facilitate servicing or changing a discharge tube or modifying the position of a discharge tube with respect to a orifice of a detector and/or a nebulizing gas conduit. The apparatus features a discharge tube housing that slidably receives a discharge tube. A union coupling the discharge tube to a source of fluid is slidably mounted to a mounting assembly holding the tube housing. | 11-13-2008 |
| 20080269368 | Porous Inorganic/Organic Hybrid Materials With Ordered Domains for Chromatographic Separations and Processes for Their Preparation - Porous hybrid inorganic/organic materials comprising ordered domains are disclosed. Methods of making the materials and use of the materials for chromatographic are also disclosed. | 10-30-2008 |
| 20080264848 | Mobile phase dilution scheme for enhanced chromatography - A method and device for increasing the loading capacity of a chromatography column through dilution of a mobile phase at the head of the column. A strong mobile phase is provided for dissolving a sample. A sample is injected into the strong mobile phase, and subsequently diluted with a weak mobile phase. The resulting sample-containing weak mobile phase is passed through a chromatography column for retention and separation of the components of the sample. | 10-30-2008 |
| 20080260558 | Device and Methods of Measuring Pressure - Embodiments of the present invention are directed to method and devices for measuring the pressure of a pump chamber in which no internal opening or connections are needed. One embodiment of the present invention is directed to an apparatus for pumping fluid. The apparatus comprises at least one housing having a transducer surface. The transducer surface has a thickness exhibiting measurable deformation upon the chamber holding a fluid under pressure such that the transducer surface has a first position at which the chamber is at one pressure and a second position at which the chamber is at a second pressure. A strain sensor is affixed to the transducer surface producing; at least one signal upon the transducer surface assuming the first position and at least one signal upon the transducer surface assuming the second position to function as an integrated pressure transducer. | 10-23-2008 |
| 20080258094 | Valve With Low Friction Coating - Embodiments of the present invention feature a method and device for controlling the flow of fluid. One embodiment of the device for controlling the flow of fluid comprises a rotor, stator and compression means. The rotor has a rotor fluid communication means and at least one rotor load bearing, surface. The rotor load bearing surface sealably engages a stationary load bearing surface. The rotor is capable of assuming a first position and a second position by rotation. The stator has a stationary load bearing surface having stator fluid communication means. The stationary load bearing surface sealably engages the rotor load bearing surface and permits rotation of the rotor with respect to the stator. At least one of the rotor bearing surface and said stator load bearing surface has a diamond-like carbon-silica coating. | 10-23-2008 |
| 20080257835 | Device, Method and Apparatus for Performing Separations - Embodiments of the present invention are directed to devices, methods and apparatus for performing separations in which particulates are separated or removed from a fluid stream flowing to a column. In one embodiment directed to a device, the invention includes a body ( | 10-23-2008 |
| 20080251141 | BACKFLOW PREVENTION FOR HIGH PRESSURE GRADIENT SYSTEMS - Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention adds sufficient minimum flow resistance, thereby enhancing the performance of the pulse dampening over a wider range of flow rates resulting in consistent gradient performance. | 10-16-2008 |
| 20080245136 | Closed Loop Flow Control of a Hplc Constant Flow Pump To Enable Low-Flow Operation - A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent compositions gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate anti precise flow delivery at capillary (<0.1 mL/min) and nano-scale (<μL/min) HPLC flow rates. | 10-09-2008 |
| 20080237130 | Compositions and Methods for Separating Enantiomers - A liquid chromatography system comprising a chiral mobile phase used to separate enantiomeric molecules present in a sample is disclosed herein. In one aspect, the mobile phase comprises a chiral solvent. In another aspect, the mobile phase includes a chiral solvent but also a buffering agent. The liquid chromatography system described herein includes both high pressure liquid chromatography (HPLC) as well as high pressure capillary liquid chromatography (CapLC). | 10-02-2008 |
| 20080236243 | Pressure Monitor Optimization of Fluid Path Utilization - A device comprising a pressure monitor and a control means that receives a signal representing measured pressure at the pressure monitor and controls the controllable elements of a fluid system is utilized to monitor a fluid system for error conditions, to optimize operations and to diagnose the fluid system. By following a testing protocol that selectively enables parts of the system, the control means narrows the list of possible failing components. Comparing the measured pressure against normal pressures allows the device to identify error conditions. Determining the volume of fluid being transported and controlling the duration of the flow optimizes operation of the fluid system. | 10-02-2008 |
| 20080206067 | High Pressure Pump Control - A feedback control loop for a high pressure pump modifies the accumulator velocity and pressure during solvent transfer. The accumulator velocity is adjusted to maintain the system pressure equal to the expected pressure to thereby eliminate the effect of the flow deficit created by a thermal effect. | 08-28-2008 |
| 20080197078 | Hplc Capillary Column Device - A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection. | 08-21-2008 |
