| WASHINGTON UNIVERSITY IN ST. LOUIS Patent applications |
| Patent application number | Title | Published |
|---|
| 20120034550 | Palladium-Platinum Nanostructures And Methods For Their Preparation - Palladium-seeded, dendritic platinum nanostructures that are useful as electrocatalysts and methods for preparing such nanostructures. The palladium-platinum nanostructures may be incorporated into fuel cell electrodes including fuel cells that include a proton exchange membrane (PEM). | 02-09-2012 |
| 20120022392 | Correlating Frequency Signatures To Cognitive Processes - Determining an intended action based on one more brain signal frequencies includes establishing communication with one or more electrodes for sensing brain signals of a subject, and acquiring the brain signals via the electrodes while the subject performs at least one cognitive task, wherein the acquired brain signals having a plurality of frequencies associated therewith. A physiologic change at one or more of the plurality of frequencies may then be identified from the acquired brain signals, and the one or more of the plurality of frequencies are associated with the cognitive task. | 01-26-2012 |
| 20120022391 | Multimodal Brain Computer Interface - Determining an intended action based on one more cortico-physiologies within brain signals includes establishing communication with one or more electrodes for sensing the brain signals of a subject, and concurrently receiving brain signals representative of a plurality of cortico-physiologies. The brain signals are transmitted to a processor for use in determining the intended action and controlling a device. | 01-26-2012 |
| 20110295143 | BRAIN FUNCTION MAPPING - A method for identifying a functional area of a brain. The functional area is associated with a neurological function. The method includes applying a plurality of electrodes to a surface of the brain. A slow cortical potential is determined based on one or more electrical signals produced by the plurality of electrodes. A covariance pattern is computed based on the slow cortical potential, and the configuration of co-varying electrodes is used to identify one or more areas of the brain associated with the neurological function. These co-varying patterns may be used in conjunction with other electrical and/or physiological stimulation paradigms. | 12-01-2011 |
| 20110282432 | Vascular Graft With Lateral Opening - A vascular graft includes a flexible conduit including a sidewall defining a cavity extending between a first end and a second end. The first end includes an opening that is oriented substantially perpendicular to a centerline axis of the conduit. The second end includes a end wall and a tapered portion extending from the sidewall to the end wall such that the cavity includes a first diameter defined at the first end and a second diameter defined at the second end that is smaller than the first diameter. A lateral opening extends through the sidewall and is oriented substantially parallel to the centerline axis. The lateral opening positioned near the second end and is sized to provide flow communication between the cavity and a blood vessel. | 11-17-2011 |
| 20110282183 | Diagnosis Of Central Nervous System White Matter Pathology Using Diffusion MRI - Determining diffusivity of multiple diffusion components within a tissue using diffusion magnetic resonance data representing a volume of the tissue. A plurality of candidate fibers having a direction is defined within the volume. A possibility coefficient is calculated by a processor for each candidate fiber of the plurality of candidate fibers based on the magnetic resonance data and the direction of the candidate fiber. The possibility coefficient represents a likelihood that the candidate fiber exists in the volume. Candidate fibers associated with a possibility coefficient greater than a threshold value are selected by the processor to create one or more probable fibers. For each probable fiber of the one or more probable fibers, an axial diffusivity indicating a diffusion of water in the direction of the probable fiber and a radial diffusivity indicating a diffusion of water perpendicular to the direction of the probable fiber are calculated by the processor. The diffusivity of isotropic diffusion component and the volume ratios of each fiber component and isotropic components are calculated. | 11-17-2011 |
| 20110275890 | MINIATURIZED PHOTOACOUSTIC IMAGING APPARATUS INCLUDING A ROTATABLE REFLECTOR - A reflection-mode photoacoustic endoscope includes a light source configured to emit a light pulse, a signal detection or transmission unit configured to detect or emit an ultrasonic pulse, and a rotatable reflector. The rotatable reflector is configured to reflect at least one of the light pulse and the ultrasonic pulse into a target area of an object, and reflect a response signal to the signal detection unit. The response signal is one of a photoacoustic wave generated by the object responsive to the light pulse and an ultrasonic pulse echo generated by the object responsive to the ultrasonic pulse. | 11-10-2011 |
| 20110251515 | IMPLANTABLE PRESSURE INDICATOR WITH EXTERNAL INTERROGATION - Observing intracranial physiology includes inserting a bladder at least partially filled with a fluid into a subdural region of interest within a subject, wherein the bladder is coupled in flow communication with a means of indicating a pressure exerted on the bladder within the region of interest. Embodiments also include non-invasively interrogating the means of indicating to determine the pressure exerted on the bladder. | 10-13-2011 |
| 20110251473 | Bipolar Sieve Electrode And Method Of Assembly - Apparatus for providing an interface between a nerve and an external information system. The apparatus includes a substrate having a first surface, an opposite second surface, and an electrode body, wherein the electrode body includes a plurality of holes extending therethrough. The apparatus also includes a plurality of electrical leads embedded within the substrate and a plurality of ring electrodes, wherein each of the ring electrodes circumscribes a corresponding hole, and wherein at least a portion of the ring electrodes is positioned on each of the first surface and the second surface. | 10-13-2011 |
| 20110208058 | Applying Renyi Entropy To Detect Changes In Scattering Architecture - A method for imaging a region of interest (ROI) within a body. The method includes applying ultrasound energy to the ROI, receiving ultrasound data for the ROI in response to the applied ultrasound energy, executing a moving window analysis on the received ultrasound data to generate a plurality of windows of information, applying a Renyi entropy signal receiver to each of the generated windows to generate Renyi entropy data, and presenting an image of the ROI based on the Renyi entropy data. | 08-25-2011 |
| 20110201914 | Reflection-Mode Photoacoustic Tomography Using A Flexibly-Supported Cantilever Beam - Noninvasively imaging biological tissue using a handheld device. A light pulse is focused into a predetermined area inside an object using a flexibly mounted cantilever beam, acoustic waves emitted by the object in response to the at least one light pulse are detected by a transducer, and an image of the predetermined area inside the object is generated based on a signal generated by the transducer representative of the acoustic waves. | 08-18-2011 |
| 20110190649 | Systems And Methods For On-Site And Real-Time Electrocardiographic Imaging (ECGI) - A computer-implemented method for electrocardiographic imaging (ECGI) is provided. The method includes computing a transfer matrix, measuring a plurality of electrical potentials, and computing an estimation of electrical potentials on a surface of interest based at least in part on the measured potentials and the computed transfer matrix. The transfer matrix computing step is performed prior to the measuring step. | 08-04-2011 |
| 20110139970 | Nanoscale Object Detection Using A Whispering Gallery Mode Resonator - Detection of individual objects using a light source and a whispering gallery mode (WGM) resonator. Light from the whispering gallery mode (WGM) resonator is analyzed. The presence of an object is determined based on mode splitting associated with the light received by the photodetector. For example, the presence of the object may be determined based on the distance between two whispering gallery modes and/or the linewidths of the two modes in a transmission spectrum. Alternatively, the presence of the object may be determined based on a beat frequency that is determined based on a heterodyne beat signal produced by combining split laser modes in the received light from a WGM microcavity laser. | 06-16-2011 |
| 20110015165 | MODIFIED, HYDROXY-SUBSTITUTED AROMATIC STRUCTURES HAVING CYTOPROTECTIVE ACTIVITY - The present invention is directed to a process for conferring cytoprotection on a population of cells which comprises administering to that population of cells a compound comprising a hydroxy-substituted aromatic ring structure and a non-fused polycyclic, hydrophobic substituent attached thereto. In particular, the present invention is directed to such a process wherein the administered compound is phenolic, such as a steriod (e.g., estrogen), and has a non-fused polycyclic, hydrophobic substituent attached to the hydroxy-substituted A-ring thereof. | 01-20-2011 |
| 20100268042 | CONFOCAL PHOTOACOUSTIC MICROSCOPY WITH OPTICAL LATERAL RESOLUTION - A confocal photoacoustic microscopy system includes a laser configured to emit a light pulse, a focusing assembly configured to receive the light pulse and to focus the light pulse into an area inside an object, an ultrasonic transducer configured to receive acoustic waves emitted by the object in response to the light pulse, and an electronic system configured to process the acoustic waves and to generate an image of the area inside the object. The focusing assembly is further configured to focus the light pulse on the object in such a way that a focal point of the focusing assembly coincides with a focal point of the at least one ultrasonic transducer. | 10-21-2010 |
| 20100223679 | TARGETED AND REGIONAL CELLULAR ABLATION IN ZEBRAFISH - A system including: (i) a methodology for targeted cellular ablation in zebrafish; (ii) a methodology for regional cellular ablation in zebrafish. These methodologies are used to identify genetic components that regulate cellular regeneration and to identify drug compounds that influence cellular regeneration for the purpose of developing therapies for degenerative conditions. Transgenic zebrafish disclosed herein contain transgenic constructs composed of: (i) cell and/or tissue-type specific regulatory elements (e.g. promoter and/or enhancer regions) which delimit expression of operably linked gene product(s) to discrete cellular populations; (ii) a gene product that promotes cellular ablation composed of a pro-drug conversion system capable of converting nontoxic pro-drugs into cytotoxic drugs, which is expressed alone or in connection with; (iii) a reporter gene product that allows selective detection of cells expressing the reporter—both prior to (initial cells) and following cellular ablation (regenerated cells). Here we describe genetic delivery of a pro-drug converting system in order to enable targeted cellular ablation in zebrafish, Transgenic zebrafish of this invention provide a high-throughput system for genetic dissection of the process of cellular regeneration and, compound screening for the discovery of drugs capable of promoting cellular regeneration. | 09-02-2010 |
| 20100183626 | HUMAN PHOSPHOLIPASE A2 EPSILON - A novel function phospholipase A | 07-22-2010 |
| 20100145990 | SELECTION AND PERFORMANCE OF HOSTED AND DISTRIBUTED IMAGING ANALYSIS SERVICES - A patient's image data and associated metadata describing the image data and characteristics of the patient are received and stored in a memory area. Information that describes one or more imaging analysis services and associated service criteria is accessed and compared to the metadata. Based on matches between the image metadata and service criteria, services are selected and executed, producing an output. Iterative rounds of service matching based on the metadata and the output of previous services and service execution proceed. The output of the services is associated with the image data and metadata, stored in the memory area, and made available to the user. A data repository, including the original images, metadata, and service output is accessible via the services for use in comparative analyses. Such services can utilize the repository to dynamically update indices and algorithms used in the comparative analyses. | 06-10-2010 |
| 20100079768 | OPTICAL COHERENCE COMPUTED TOMOGRAPHY - A system, method, and device for imaging a sample. In embodiments, a light from a low-coherence source or a wavelength-swept source is used to illuminate the sample. Pathlength-resolved intensity profiles of the light reemitted from the sample are recorded and measurements are taken. A reconstruction algorithm is used to invert the pathlength-resolved measurements to form an image. | 04-01-2010 |
| 20100048595 | USE OF ARCHAEA TO MODULATE THE NUTRIENT HARVESTING FUNCTIONS OF THE GASTROINTESTINAL MICROBIOTA - The invention generally relates to the use of archaea to modulate nutrient harvesting in a subject. In particular, the invention provides methods that use archaea to modulate the nutrient harvesting functions of the microbiota in the subject's gastrointestinal tract. | 02-25-2010 |
| 20100016917 | CARDIAC PACING USING THE INFERIOR NODAL EXTENSION - A device and method for providing stimulation to an inferior nodal extension of a heart. The method includes providing a lead comprising an electrode, positioning the electrode proximate an inferior nodal extension of a heart, and effecting at least one of activation, deactivation, or modulation of the electrode to provide stimulation to the inferior nodal extension. | 01-21-2010 |
| 20100015091 | MODIFIED STAT1 TRANSGENE THAT CONFERS INTERFERON HYPERRESPONSIVENESS, METHODS AND USES THEREFOR - Methods of enhancing cellular responses to interferons are disclosed. These methods comprise administering to a subject a vector comprising a Stat1-CC transgene, such as an AAV5 vector comprising a reporter operably linked to a nucleic acid sequence encoding a Stat1-CC polypeptide. The methods can be used in the treatment of diseases that involve interferon responses, such as multiple sclerosis, amyotrophic lateral sclerosis, and lupus; viral infections such as infection by hepatitis C virus, influenza A virus, cowpox virus, Sendai virus or Encephalomyocarditis virus; respiratory disorders; and cancers. | 01-21-2010 |
| 20100001184 | MINIATURIZED ULTRAFINE PARTICLE SIZER AND MONITOR - An apparatus for measuring particle size distribution includes a charging device and a precipitator. The charging device includes a corona that generates charged ions in response to a first applied voltage, and a charger body that generates a low energy electrical field in response to a second applied voltage in order to channel the charged ions out of the charging device. The corona tip and the charger body are arranged relative to each other to direct a flow of particles through the low energy electrical field in a direction parallel to a direction in which the charged ions are channeled out of the charging device. The precipitator receives the plurality of particles from the charging device, and includes a disk having a top surface and an opposite bottom surface, wherein a predetermined voltage is applied to the top surface and the bottom surface to precipitate the plurality of particles. | 01-07-2010 |
| 20090292210 | TASK-LESS OPTICAL MAPPING OF BRAIN FUNCTION USING RESTING STATE FUNCTIONAL CONNECTIVITY - A method for utilizing an optical system for mapping brain function includes determining a time series of light intensity measurements for spatially distributed source and detector pairs, receiving light measurements over a period of time, and producing at least one map of a respective strength of each of a plurality of temporal correlations, wherein the temporal correlations are based on the time series of the spatially distributed source and detector pairs and the light measurements. | 11-26-2009 |
| 20090281522 | METHODS OF INHIBITING SEIZURE IN A SUBJECT - The present invention relates to methods of inhibiting seizure in a subject. In particular, the invention provides methods of increasing brain leptin levels in a subject. | 11-12-2009 |
| 20090264355 | METHODS TO TREAT ALZHEIMER'S DISEASE OR OTHER DISORDERS MEDIATED BY AMYLOID-BETA ACCUMULATION IN A SUBJECT - The invention provides methods of delaying the onset, slowing the progression, preventing, or treating Alzheimers disease in a subject. In particular, the invention provides methods of modulating transport of Aβ across the blood brain barrier of the subject. | 10-22-2009 |
| 20090263829 | ALZHEIMER'S DISEASE BIOMARKERS AND METHODS OF USE - The invention encompasses biomarkers for AD, a method for detecting AD, a method of monitoring AD, and a kit for quantifying biomarkers for AD. | 10-22-2009 |
| 20090253620 | METHODS AND COMPOSITIONS FOR TREATING GASTROINTESTINAL RADIOSENSITITIVITY IN A SUBJECT - A method and a related composition for treating gastrointestinal radiation sensitivity in a subject are disclosed. The method comprises administering to the subject an agent that increases either the amount of or the activity of a fasting-induced adipose factor (Fiaf) protein in a subject. The composition comprises a first agent that increases either the amount of or the activity of a fasting-induced adipose factor (Fiaf) protein in a subject and a second agent that ameliorates at least one symptom of gastrointestinal radiosensitivity in a subject. | 10-08-2009 |
| 20090214616 | BIOMATERIALS HAVING NANOSCALE LAYERS AND COATINGS - The invention generally relates to substrates and surfaces having substrates. Generally speaking, the substrates may be thinly layered substrates, and the surfaces may comprise thinly layered substrates. Additionally, the substrates may comprise a multifunctional water soluble polymer and a lipoprotein and the surfaces may comprise a multifunctional water soluble polymer and a lipoprotein. | 08-27-2009 |
| 20090209869 | PRESSURE RECOVERY INDEX TO ASSESS CARDIAC FUNCTION - Determining an index for assessing cardiac function. In an embodiment, a method includes receiving ventricular pressure data during an invasive cardiac procedure, wherein the received pressure data includes a diastatic ventricular pressure value, a minimum ventricular pressure value, and a predefined fiducial marker pressure value. An index value is calculated by comparing a first pressure difference to a second pressure difference. The first pressure difference represents the difference between the received diastatic ventricular pressure value and the received minimum ventricular pressure value. The second pressure difference represents the difference between the received fiducial marker pressure value and the received minimum ventricular pressure value. The index value is provided to a health care provider to assess early diastolic cardiac function. | 08-20-2009 |
| 20090208953 | NEUROFIBROMIN PATHWAY MODULATORS - The present invention encompasses methods for treating neurofibromatosis and methods for screening for modulators of the neurofibromin pathway. | 08-20-2009 |
| 20090191645 | COMPOUNDS AND METHODS FOR MODULATING INTEGRIN ACTIVITY - The present invention provides methods and compositions for modulating integrin activity. In particular, the present invention encompasses methods and compositions for altering the interaction between the α and β chain extracellular clasp regions. | 07-30-2009 |
| 20090184435 | CONTROLLING THE SYNTHESIS AND GEOMETRY OF LIPID TUBULE NETWORKS - Nano-sized lipid vesicles with tailored properties are used as building blocks to generate lipid tubules between two glass surfaces. The tubules formed not only have defined orientation, width, and length, but they can also grow to be as long as 13 mm under ambient conditions, without externally supplied flow, temperature control, or catalyzing agents. The tubule membrane and its internal aqueous content can be manipulated by controlling the combination of different vesicle's lipid composition and aqueous entrapment. This self-assembly process opens up new pathways for generating complicated and flexible architectures for use in biocompatible molecular and supramolecular engineering. Aspects of the invention generate, for example, tubules encapsulated with siRNA, tubules with multiple branches, and polymerized fluorescent tubules in a single-throughput self-assembly process. | 07-23-2009 |
| 20090176878 | GENETIC POLYMORPHISMS AND SUBSTANCE DEPENDENCE - The invention encompasses a method for identifying subjects at risk for substance dependence by detecting the presence of polymorphism in the CHRNA5-CHRNA3-CHRNB4 gene cluster and the CHRNA4 gene. The invention also encompasses determining the response of a subject to a therapeutic substance, treating substance dependence in a subject, and evaluating the response of a subject to a substance cessation treatment. | 07-09-2009 |
| 20090174937 | OBJECTIVE-COUPLED SELECTIVE PLANE ILLUMINATION MICROSCOPY - A microscope assembly ( | 07-09-2009 |
| 20090171210 | SONOELECTRIC TOMOGRAPHY USING A FREQUENCY-SWEPT ULTRASONIC WAVE - Sonoelectric tomography to achieve high-resolution bioelectric imaging. Bioelectrical signals originating from various locations in an object are ultrasonically encoded to carry different frequencies that vary with time via a frequency-swept signal or chirp. The frequency-sweeping parameters are chosen so that no frequencies are duplicated in the medium at any given time. The frequency distribution is decoded, for example, by means of the Fourier transformation to recover a bioelectric image with high spatial resolution. The spatial resolution of the image is defined by the ultrasonic frequency parameters, whereas the image contrast is derived from the bioelectric signals. In an embodiment, an ultrasonic transducer transmits a frequency-swept (e.g., chirped) ultrasonic wave into the region of interest in the tissue. The ultrasonic wave may be focused to achieve high transverse resolution within the focal zone. | 07-02-2009 |
| 20090156510 | USE OF NOTCH SIGNALING REGULATORS FOR MODULATING OSTEOGENESIS - The present invention provides methods of treating osteoporosis and other bone disorders by inhibiting Notch signaling. | 06-18-2009 |
| 20090143294 | METHODS OF TREATING VASODILATORY SHOCK - The invention encompasses methods of decreasing the lumenal diameter of a blood vessel by contacting the vessel with a myosin light chain phosphatase inhibitor. | 06-04-2009 |
| 20090142823 | ATTENUATED RNA VIRUS AND APPLICATIONS THEREOF - The invention encompasses an attenuated RNA virus and methods of using an attenuated RNA virus. The RNA virus comprises, in part, an ion channel protein comprising a peptide tag. | 06-04-2009 |
| 20090142766 | METHODS FOR MEASURING THE METABOLISM OF CNS DERIVED BIOMOLECULES IN VIVO - The present invention provides methods for measuring the metabolism of a central nervous system derived biomolecule implicated in a neurological and neurodegenerative disease or disorder. In particular, the method comprises measuring the in vivo metabolism of the biomolecule in the central nervous system of a subject. Also provided is a method for determining whether a therapeutic agent affects the in vivo metabolism of a central nervous system derived biomolecule. | 06-04-2009 |
| 20090138215 | Photoacoustic Doppler Flow Sensing and Imaging - A method for measuring a fluid flow includes employing small light-absorbing particles as tracers that flow at the same speed as the fluid, measuring the photoacoustic Doppler shifts of the photoacoustic signals produced by these tracer particles, and determining, from the measurements, information about the flow including one or more of the flow speed, flow profile, and flow direction. | 05-28-2009 |
| 20090124792 | FLUORESCENT POLYMETHINE CYANINE DYES - The invention encompasses fluorescent cyanine dyes and methods of using such dyes. In particular, the invention encompasses near infrared polymethine cyanine dyes. | 05-14-2009 |
| 20090068701 | SYSTEMS AND METHODS FOR SCREENING PHARMACEUTICAL CHEMICALS - A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and tissue stiffness. A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and hysteresis. | 03-12-2009 |
| 20090035298 | METHODS TO TREAT ALZHEIMER'S DISEASE OR OTHER AMYLOID BETA ACCUMULATION ASSOCIATED DISORDERS - The present invention provides methods for treating amyloid-beta accumulation-associated disorders, such as Alzheimer's disease. The methods comprise modulating the concentration of amyloid-beta in the brain interstitial fluid. In particular, the methods comprise modulating the activity of corticotrophin-releasing factor (CRF), which in turn modulates the concentration of amyloid-beta. | 02-05-2009 |
| 20090029473 | LIPID PROFILE AS A BIOMARKER FOR EARLY DETECTION OF NEUROLOGICAL DISORDERS - The present invention relates to compositions and methods for the early detection or monitoring of neurodegenerative diseases and neurological disorders including Alzheimer's disease. The invention provides biomarkers based on lipid profiles of biological samples and methods for using the biomarkers for the detection of neurodegenerative diseases and neurological disorders. | 01-29-2009 |
| 20090028788 | COMPOUNDS HAVING RD TARGETING MOTIFS - The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated to an agent selected from an imaging agent and a targeting agent. The compounds may be used to detect, monitor and treat a variety of disorders mediated by integrins. | 01-29-2009 |
| 20090005843 | DEPTH COOLING IMPLANT SYSTEM - A depth cooling implant system having a probe device implanted inside a targeted area of the brain, such as the medial temporal lobe, for the treatment of epilepsy is disclosed. The probe device includes a heat pipe having a sensor for detecting the temperature of surrounding brain tissue as well as a plurality of recording electrodes for monitoring EEG activity of the brain. Further, the heat pipe defines a proximal portion in operative engagement with a cooling chip that provides a nearly instantaneous cooling effect to the heating pipe in order to immediately cool the targeted area of the brain when an epileptic seizure is detected. The probe device is operatively associated with a probe controller having a computer and battery arrangement that may be implanted in the patient in order to monitor brain activity and selectively activate the cooling chip for cooling the medial temporal lobe in response to an epileptic seizure. | 01-01-2009 |
| 20080300168 | INHIBITION OF MIGRATION AND INDUCTION OF CELL DEATH BY THE TYPE II COLLAGEN AMINO PROPEPTIDES - The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an αvβ3 and/or an αvβ5 integrin. | 12-04-2008 |
| 20080269464 | COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCTE ACTIVITY - The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided. | 10-30-2008 |
| 20080233589 | Complementation Systems Utilizing Complexes of Heteroproteins - The present invention provides heterologous complementation systems and methods of using the systems to detect molecular interactions. In particular, the heterologous complementation systems comprise polypeptide fragments derived from heterologous polypeptides. If a molecular interaction occurs, then the heterologous polypeptide fragments are able to associate and produce a detectable signal. | 09-25-2008 |
| 20080214682 | METHODS OF TREATING PNEUMONIC PLAGUE - The present invention relates to methods of treating pneumonic plague. More specifically, the present invention relates to methods of using plasmin or Pla inhibitors to treat pneumonic plague. | 09-04-2008 |
