| VRIJE UNIVERSITEIT BRUSSEL Patent applications |
| Patent application number | Title | Published |
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| 20120133535 | Interleaved Pipelined Binary Search A/D Converter - The present invention is related to a pipelined analog-to-digital converter, ADC, for converting an analog input signal into a digital signal comprising—a plurality of comparing means having tuneable thresholds for comparing an input signal with; at least two of said given thresholds being different and—a plurality of amplifying circuits,—wherein said plurality of comparing means is configured to form a hierarchical tree structure, said hierarchical tree structure having a plurality of hierarchical levels, wherein at least one of said hierarchical levels is associated with at least one amplifying circuit of said plurality of amplifying circuits, said at least one amplifying circuit generating the input of at least one comparing means at the next hierarchical level and—wherein said plurality of hierarchical levels comprises means for setting said tuneable thresholds in accordance to the output of previous hierarchical level so that non-linear distortion of the preceding hierarchical level is removed. | 05-31-2012 |
| 20120115163 | MARKED PEPTIDES AND USE THEREOF FOR ASSAYING CIRCULATING IRAP - A method for the assay of the circulating extracellular portion of the IRAP protein (“insulin responsive aminopeptidase”) includes at least one stage of quantitative assay of the purified, secreted, extracellular portion of IRAP, via at least one labelled peptide, the labelled peptide interacting specifically with the extracellular portion of IRAP. | 05-10-2012 |
| 20120094864 | EXTRACELLULAR ALLOSTERIC INHIBITOR BINDING DOMAIN FROM A TYROSINE KINASE RECEPTOR - The present invention relates to an extracellular binding domain for an allosteric inhibitor, whereby said binding domain is derived from a single membrane span tyrosine kinase receptor. More specifically, the invention relates to an extracellular domain derived from a Fibroblast Growth Factor Receptor (FGFR). It further relates to the use of this domain for the identification of similar domains in the extracellular part of other tyrosine kinase receptors, and to a screening method for identification of a small compound allosteric inhibitor. | 04-19-2012 |
| 20120077412 | HIVE-MOUNTED DISSEMINATOR DEVICE - The present invention relates to the dissemination of biological control agents or other substances through the use of bees, in particular bumblebees. It relates to a disseminator device, installable in or in connection to the hive, and which contains biological control agents or other substances which are picked up, carried and disseminated by the bees when leaving the hive. | 03-29-2012 |
| 20120023624 | MEANS AND METHODS FOR MEDIATING PROTEIN INTERFERENCE - The present invention belongs to the field of functional proteomics and more particularly to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as interferor, that has a specificity for a target protein and which induces aggregation upon contact with said target protein. The present invention also discloses such interferor molecules and their use in agrobiotech applications. | 01-26-2012 |
| 20120011921 | METHOD FOR IMPROVING THE EFFICIENCY OF HIGH-PRESSURE LIQUID CHROMATOGRAPHY - The present invention relates to a method for improving the efficiency of high-pressure liquid chromatography columns in HPLC. More specifically, the method of the present invention provides a high-pressure liquid chromatography column being divided into a multitude of shorter separation segments, the shorter separation segments being serially connected with cooling segments. By applying an active controlled cooling action on the fluid flow passing through the cooling segments the separation efficiency of the high-pressure liquid chromatography column can be increased significantly. | 01-19-2012 |
| 20110262348 | Selective targeting of intratumoral cells - The present invention relates to the field of tumor growth and biology. The invention relates to activities and characteristics of tumor-associated macrophages, and uses of such for the diagnosis and treatment of cancer and tumor growth. | 10-27-2011 |
| 20110257372 | IMMUNOGLOBULINS DEVOID OF LIGHT CHAINS - There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains. | 10-20-2011 |
| 20110244011 | SPECIFIC DELIVERY OF AGROCHEMICALS - The present invention relates to specific delivery of agrochemicals to plants. More specifically, it relates to a composition, essentially consisting of a targeting agent comprising at least one binding domain that specifically binds to a binding site on an intact living plant and an agrochemical or a combination of agrochemicals. The present invention relates further to a binding domain that specifically binds the binding site on an intact living plant. More specifically, it relates to binding domains comprising an amino acid sequence that comprises four framework regions and three complementary determining regions, or any suitable fragment thereof, whereby the binding domains are capable to bind or retain a carrier onto a plant. In one preferred embodiment, the invention relates to binding domains which specifically bind trichomes, stomata, cuticle, lenticels, thorns, spines, root hairs, or wax layer. The invention relates further to a method for delivery of agrochemicals to a plant, for improving the deposition of agrochemicals on a plant, and for retaining the agrochemicals on a plant, using targeting agents comprising the binding domains, and to a method for protecting a plant against biotic or abiotic stress or controlling plant growth using the same. Also, the invention relates to a method for manufacturing a specifically targeting agrochemical carrier. | 10-06-2011 |
| 20110232373 | CHROMATOGRAPHIC SEPARATION DEVICE WITH VARIABLE LENGTH AND A METHOD FOR ITS USE - The present invention enables the automatic change of the number of segments involved in a coupled chromatographic column system, without the need to physically detach and attach the individual segments. The present invention further relates to a method for performing method development in chromatography and for selecting the optimal separation conditions to perform a chromatographic separation using the system of the present invention. | 09-29-2011 |
| 20110091446 | SINGLE DOMAIN ANTIBODIES CAPABLE OF MODULATING BACE ACTIVITY - The present invention relates to single domain antibodies with a specificity for BACE1. More specifically, the invention provides single variable domain antibodies derived from camelids which bind to BACE1 and are capable of inhibiting the activity of BACE1. Said antibodies can be used for research and medical applications. Specific applications include the use of BACE1 specific antibodies for the treatment of Alzheimer's disease. | 04-21-2011 |
| 20110063614 | PHOTOSPECTROMETER - Impinging electromagnetic radiation generates pairs of majority and minority carriers in a substrate. A spectrometer device for detection of electromagnetic radiation impinging on a substrate comprises means for generating, in the substrate, a majority carrier current; at least one detection region for collecting generated minority carriers, the minority carriers being directed under influence of the majority carrier current; and means for determining spectral information based on minority carriers collected at the at least one detection region. | 03-17-2011 |
| 20110052635 | LIVE ATTENUATED SALMONELLA VACCINE - The present invention is related to double and triple attenuated mutant strains of a bacterium infecting veterinary species such as | 03-03-2011 |
| 20100330049 | METHOD FOR GENERATING ISLET BETA CELLS FROM DEDIFFERENTIATED EXOCRINE PANCREATIC CELLS - The present invention relates to an in vitro method for generating insulin-producing beta cells from a population of mammalian cells comprising dedifferentiated exocrine pancreatic cells. The method comprises the step of culturing said dedifferentiated exocrine pancreatic cells in a culture medium in the presence of at least one agent that is able to inhibit the Notch 1 signaling pathway in said dedifferentiated exocrine pancreatic cells, and at least one ligand of the gp130 receptor and/or at least one ligand of the EGF receptor. The invention further provides a population of mammalian pancreatic cells comprising insulin-producing beta cells obtainable by the present method and uses thereof in a pharmaceutical composition for treating type 1 or type 2 diabetes. | 12-30-2010 |
| 20100301946 | Switchable Multiband LNA Design - A low noise amplifying (LNA) circuit comprising an amplifying section ( | 12-02-2010 |
| 20100283649 | Sigma-delta-based analog-to-digital converter - An analog to digital converting device is proposed for generating a digital output signal of an RF analog input signal. The device comprises a first analog to digital converter stage, a mixer, a second analog to digital converter stage and a digital filter. The first analog to digital converter stage generates a first and a second output signal. The first output signal is inputted in the filtering means. The second output signal is being down-converted to a signal with an intermediate frequency or DC. Thereafter, this down-converted signal is being fed to the second analog to digital converter stage. The digital output signal of this second stage is further processed together with the first digital output signal in the digital filter to a digital signal representative of the analog input signal. | 11-11-2010 |
| 20100278782 | DIFFERENTIATION OF RAT LIVER EPITHELIAL CELLS INTO HEPATOCYTE-LIKE CELLS - Methods for differentiation of cells of a rat liver epithelial (RLEC) cell line to hepatocyte-like cells are disclosed. In particular, methods involve sequential exposure of the RLEC to two or more differentiation agents. Cells obtained by the method are described as well as their uses in various pharmacological, toxicological, therapeutic, diagnostic and research applications. | 11-04-2010 |
| 20100215674 | ENHANCING THE T-CELLS STIMULATORY CAPACITY OF HUMAN ANTIGEN PRESENTING CELLS AND THEIR USE IN VACCINATION - With the current invention, we provide new methods of enhancing the T-cell stimulatory capacity of human dendritic cells (DCs) and their use in cancer vaccination. The method comprises the introduction of different molecular adjuvants to human DCs through transfection with at least two mRNA or DNA molecules encoding markers selected from the group of: CD40L, CD70, constitutively active TLR4 (caTLR4), IL-12p70, EL-selectin, CCR7 and/or 4-1 BBL; or in combination with inhibition of SOCS, A20, PD-L1 and/or STAT3 expression, for example through siRNA transfection. We could show a clear increase in the immunostimulatory capacity of DCs obtained in this way, enabling them to elicit an unexpectedly high T-cell immune response in vitro. Introduction of at least two of the above molecules, in combination with a tumor-specific antigen enables the DCs to elicit a significant host-mediated T-cell immune response in vivo against the tumor antigen and thus makes them very attractive in the manufacturing of anti-cancer vaccines. | 08-26-2010 |
| 20100196929 | STABILISATION OF THE PHENOTYPIC PROPERTIES OF ISOLATED PRIMARY CELLS - The invention provides a method for stabilisation of phenotypic properties of isolated primary cells comprising modulating at least two epigenetic modifications in said cells. | 08-05-2010 |
| 20100166611 | DEVICE FOR THE DISTRIBUTION OF SAMPLE AND CARRIER LIQUID ACROSS A MICRO-FABRICATED SEPARATION CHANNEL - The present invention relates to a chromatographic separation device comprising a first substrate body carrying a micro-fabricated separation channel recessed on one of its surfaces and covered by a second substrate body, both perforated with connection-holes for the supply and withdrawal of a sample and carrier liquid. The present device is characterized in that said micro-fabricated separation channel is preceded or succeeded by a flow distribution region that is filled with an array of micro-fabricated pillars, having a shape, size and positioning pattern selected such that said flow distribution region has a ratio of transversal to axial permeability of at least 2. | 07-01-2010 |
| 20090209433 | METHOD FOR SCREENING AND SELECTING LIGANDS - The present invention provides a method for screening of ligands wherein the target is a membrane protein, which is reconstituted into a membrane environment, using the surface plasmon resonance (SPR) technology. In particular, the target is a VDAC protein. | 08-20-2009 |
| 20090128906 | Folded Radial Brewster Polariser - A compact polarisation selection device ( | 05-21-2009 |
| 20080199472 | Use of a polypeptide domain to modulate the tumorigenic and metastatic potential of cancer cells - The present invention reates to the use of a polypeptide domain to modulate the tumorigenic and metastatic potential of cancer cells. More specifically, the present invention relates to a domain of a Secretory Leukocyte Protease Inhibitor (SLPI) to modulate tumor invasiveness and/or metastasis. It further relates to compounds, such as antibodies, that interact with the domain and repress the tumor invasiveness and/or the metastasis. | 08-21-2008 |
