Vanderbilt University Patent applications |
Patent application number | Title | Published |
20160102090 | SUBSTITUTED 3-BENZYLQUINOXALIN-4(3H)-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYCHOLINE RECEPTOR M1 - In one aspect, the invention relates to 3-benzylquinazolin-4(3H)-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 04-14-2016 |
20160068525 | Fused Heterocyclic Compounds as Selective BMP Inhibitors - The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. | 03-10-2016 |
20160054207 | Low Resource Sample Processor Containing Heat-Activated Surface Tension Valves - Systems and methods are described for isolation, separation and detection of a molecular species using a low resource device for processing of samples. Methods include isolation, separation and detection of whole cells as well as biomolecules including viruses, proteins, nucleic acids, carbohydrates and lipids. | 02-25-2016 |
20160030528 | ANTIMICROBIAL MURAMIDASE - glycosyl hydrolase 25 (GH25) muramidase is shown here to exhibit antibacterial activity against several distinct bacterial families. Formulations and methods of use for this GH25 are provided. | 02-04-2016 |
20150379723 | AUTOMATIC SEGMENTATION OF INTRA-COCHLEAR ANATOMY IN POST-IMPLANTATION CT OF UNILATERAL COCHLEAR IMPLANT RECIPIENTS - A method for automatic segmentation of intra-cochlear anatomy of a patient. The patient has an implanted ear and a normal contralateral ear. At least one computed tomography (CT) image is obtained to generate a first image corresponding to the normal contralateral ear and a second image corresponding to the implanted ear. Intra-cochlear surfaces of at least one first structure of interest (SOI) of the normal contralateral ear in the first image are segmented using at least one active shape model (ASM). Next, the segmented intra-cochlear surfaces in the first image is projected to the second image using a transformation function, thereby obtaining projected segmented intra-cochlear surfaces for the implanted ear in the second image. | 12-31-2015 |
20150342501 | REAL-TIME POSE AND MAGNETIC FORCE DETECTION FOR WIRELESS MAGNETIC CAPSULE - Systems and methods are described for determining an orientation and position of a capsule inserted into the body of a patient. A magnetic field is applied to an area of the patient where the capsule is located. Sensor data, including inertial data from an inertial sensor and magnetic field data indicative of the applied magnetic field as detected by at least one magnetic field sensor, is wirelessly received from the capsule. An orientation angle of the capsule is determined based at least in part on the inertial data. The magnetic field data is compared to known characteristics of the applied magnetic field and a location of the capsule is determined based on the comparison. | 12-03-2015 |
20150336925 | SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS - The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein. | 11-26-2015 |
20150324305 | CHANGE MANAGEMENT SYSTEM, CHANGE MANAGEMENT METHOD, AND CHANGE MANAGEMENT PROGRAM - A change management system includes a system definition expansion unit | 11-12-2015 |
20150324211 | CHANGE PLANNING SYSTEM, CHANGE PLANNING METHOD, AND CHANGE PLANNING PROGRAM - A change planning system includes a state machine set conversion unit | 11-12-2015 |
20150323916 | FAST CHANGE PLANNING SYSTEM, FAST CHANGE PLANNING METHOD, AND FAST CHANGE PLANNING PROGRAM - A fast change planning system includes: a state machine set division unit | 11-12-2015 |
20150322163 | ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF - Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The disclosure further includes pharmaceutical compositions comprising the disclosed anti-factor XI monoclonal antibodies, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier. Methods of the disclosure include administering the compositions described above to a subject in need thereof for the purpose of inhibiting thrombosis, reducing a required dose of an antithrombotic agent in the treatment of thrombosis, treating metastatic cancer, or treating an acute inflammatory reaction. | 11-12-2015 |
20150308578 | NORMALLY CLOSED MICROVALVE AND APPLICATIONS OF THE SAME - A normally closed valve includes a plurality of fluid channels in fluid communication with each other, defined in a flexible base such that when a fluid channel is compressed, a fluid flow through the fluid channel is occluded, otherwise, the fluid flow through the fluid channel is unoccluded; and means for selectively compressing or uncompressing a desired fluid channel. | 10-29-2015 |
20150283182 | INJECTABLE ALLOGRAFT PUR COMPOSITE CARRYING rhBMP2 - Embodiments of the present inventions comprise composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. Certain embodiments further comprise a growth factor that can be provided in powder form. Growth factors may be bone morphogenic proteins, such as rhBMP-2. A porous composite comprises a plurality of bone particles, polyurethanes with which the bone particles are combined, and at least one growth factor. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications. | 10-08-2015 |
20150231302 | POLY(THIOKETAL-URETHANE) SCAFFOLDS AND METHODS OF USE - The presently-disclosed subject matter includes biodegradable scaffolds. Exemplary biodegradable scaffolds comprise a plurality of polythioketal polymers, and a plurality of polyisocyanates, where at least one polyisocyanate is linked to at least one polymer to form the scaffold. Thus, certain embodiments of scaffolds comprise a cross-linked network of the polythioketal polymers and the polyisocyanates. The presently-disclosed subject matter also includes methods for treating tissue, such as skin or bone tissue, in a subject in need thereof. Treatment methods comprise contacting the tissue with an effective amount of the biodegradable scaffold. Furthermore, the presently-disclosed subject matter includes methods for making the present biodegradable scaffolds. | 08-20-2015 |
20150223832 | SYSTEM, METHOD, AND APPARATUS FOR CONFIGURATION, DESIGN, AND OPERATION OF AN ACTIVE CANNULA ROBOT - The present invention relates to a system and apparatus for implementing a method for identifying tube parameters of a curved tube of an active cannula for operating on a target in a patient. The method includes the step (a) of acquiring a model of the patient anatomy including the target. The method also includes the step (b) of selecting a set of parameters characterizing a curved tube. The method also includes the step (c) of computing a workspace for an active cannula having the selected curved tube parameters. The method also includes the step (d) of comparing the workspace to the anatomical model to determine the degree to which an active cannula having the selected curved tube parameters covers the target. The method also includes the step (e) of repeating steps (b) through (d) through a defined number of curved tube parameter sets. The method also includes the step (f) of identifying the curved tube parameters that provide an active cannula with an optimal degree of target coverage. | 08-13-2015 |
20150209159 | PARALLELOGRAM LOAD CELL - A device includes a first member ( | 07-30-2015 |
20150183862 | ANTI-TGF-BETA INDUCTION OF BONE CELL FUNCTION AND BONE GROWTH - The invention regards the modulation of TGF-β activity by administering to a subject an antibody that binds to TGF-β, thereby increasing bone growth, bone formation, bone mass and bone strength. The antibody acts to increase osteoblast number and function while at the same time decreasing osteoclast number and function. Such drugs are useful in the treatment of diseases or disorders such as osteoporosis, Paget's disease, metastatic bone cancer, myeloma bone disease, bone fractures, etc. | 07-02-2015 |
20150142130 | MOVEMENT ASSISTANCE DEVICE - Methods for the control of an exoskeleton comprising at least one powered joint associated with lower limbs of a user and control systems therefrom are provided. A method includes estimating a configuration of a body of the user associated with the exoskeleton with respect to a gravity vector and computing a first control torque for the at least one powered joint that at least partially compensates gravitational dynamics of the user based on the configuration. The method further includes calculating a gravitational energy gradient for the at least one powered joint, attenuating the first control torque based at least on the gravitational energy gradient to yield a second control torque, and applying a final control torque at the at least one powered joint, the final control torque based, at least in part, on the second control torque. | 05-21-2015 |
20150093395 | ANTI-FXI ANTIBODIES AND METHODS OF USE - Disclosed herein are monoclonal antibodies specific for factor XI (fXI) that prevent activation of fXI by factor XIIa (fXIIa). The monoclonal antibodies are universal fXI antibodies, capable of binding all mammalian species tested. The anti-fXI monoclonal antibodies prolong clotting time in mammalian plasmas. Moreover, administration of the fXI monoclonal antibodies disclosed herein results in inhibition of thrombosis without altering hemostasis in animal models of thrombosis. Thus, provided herein are monoclonal antibodies specific for fXI that block activation of fXI by fXIIa, compositions and immunoconjugates comprising such antibodies and their methods of use. | 04-02-2015 |
20150087790 | POLYCARBONATE CONTAINING COMPOUNDS AND METHODS RELATED THERETO - Disclosed herein are crosslinked polycarbonates, composition thereof and methods thereof. The cross-linked polycarbonates can be prepared from allyl or epoxy polycarbonates. Described herein is the formation of functionalized poly(carbonate) particles with an established intermolecular cross-linking process. Six types of ‘nanosponges’ were prepared with the differentiation in crosslinking density and crosslinking chemistry. The intermolecular chain cross-linking process was investigated via the epoxide amine reaction and the thiol-ene click reaction. | 03-26-2015 |
20150086540 | Methods of using an antibody to inhibit WNT-mediated cardiac remodeling - The present invention is directed to monoclonal antibodies and fragments thereof directed to LRP5/6 that find use in the prevention and treatment of cardiac remodeling and cancer. Also disclosed are methods for using such monoclonal antibodies in the prevention and treatment of such diseases. | 03-26-2015 |
20150080907 | SYSTEM AND METHOD FOR ENDOSCOPIC DEPLOYMENT OF ROBOTIC CONCENTRIC TUBE MANIPULATORS FOR PERFORMING SURGERY - An apparatus ( | 03-19-2015 |
20150025041 | ANTIVIRAL THERAPIES WITH PHOSPHOLIPASE D INHIBITORS - Disclosed are methods of treating viral infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to antiviral therapies. For example, compounds having Phospholipase D activity (e.g., isoform selective Phospholipase D inhibitors) can be useful in antiviral therapies (e.g., influenza treatments). | 01-22-2015 |
20140371261 | INDOMETHACIN ANALOGS FOR THE TREATMENT OF CASTRATE-RESISTANT PROSTATE CANCER - Provided are compositions for inhibiting a biological activity of an aldoketo reductase family 1, member C3 (AKR1 C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1 C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects. | 12-18-2014 |
20140369929 | LIGANDS TO RADIATION-INDUCED MOLECULES - A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands. | 12-18-2014 |
20140364409 | SUBSTITUTED PYRAZOLO[3',4':4,5]THIENO[2,3-C]PYRIDAZIN-3-AMINE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 - In one aspect, the invention relates to substituted pyrazolo[3′,4′:4,5]thieno[2,3-c]pyridazine-3-amine analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 12-11-2014 |
20140358162 | ROBOTIC PLATFORM FOR MINI-INVASIVE SURGERY - Robotic platform for mini-invasive surgery comprising robotic arms ( | 12-04-2014 |
20140357526 | HYDROGEL-MEDIATED TISSUE ANALYSIS - A method for analyzing the polypeptide content of animal tissue is described. The method includes the steps of (a) providing an animal tissue specimen; (b) depositing one or more portions of a hydrogel mixture including a protease on spatially discrete portions of the animal tissue specimen; (c) allowing sufficient time to pass for animal tissue under the hydrogel mixture to be form a digested mixture of animal tissue and hydrogel mixture; (d) removing the digested mixture from the animal tissue and extracting the polypeptides from the digested mixture to provide an extract; and (e) analyzing the polypeptide content of the extract by mass spectrometry. | 12-04-2014 |
20140350375 | INTEGRATED THIN-FILM OPTRODE - An optrode may provide a cylindrical substrate two or more electrodes deposited said cylindrical substrate. The cylindrical substrate and electrodes may be coated by an insulating layer with openings or vias over certain portions of the electrodes that may provide a contact for the neural probe or may be utilized to connect lead lines. Manufacturing of an optrode may utilize a jig that secures a cylindrical substrate coated by a conductive material and a resist. A first mask may be positioned in an opening provided by the jig, and the cylindrical substrate may be exposed ions or neutral particles to define one or more electrode patterns. After regions of the resist and conductive material are removed to form the electrodes, a second mask may be utilized to define vias regions in which portions of the electrodes are exposed and uncoated by an insulating layer. | 11-27-2014 |
20140349213 | COMPOSITE MEMBRANES, METHODS OF MAKING SAME, AND APPLICATIONS OF SAME - In one aspect of the present invention, a method of fabricating a composite membrane includes: forming a first polymer solution from a first polymer and a second polymer solution from a second polymer, respectively, where the first polymer includes a charged polymer and the second polymer includes an uncharged polymer; electrospinning, separately and simultaneously, the first and second polymer solutions to form a dual fiber mat with first polymer fibers and second polymer fibers; and processing the dual fiber mat by softening and flowing one of the first or second polymer fibers to fill in the void space between the other of the first and second polymer fibers so as to form the composite membrane. In some embodiments, the composite membrane may be a proton exchange membrane (PEM) or an anion exchange membrane (AEM). | 11-27-2014 |
20140336113 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HYPERLIPIDEMIA, FATTY LIVER, ATHEROSCLEROSIS AND OTHER DISORDERS ASSOCIATED WITH METABOLIC SYNDROME - The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function. | 11-13-2014 |
20140330432 | SYSTEMS AND METHODS FOR SAFE COMPLIANT INSERTION AND HYBRID FORCE/MOTION TELEMANIPULATION OF CONTINUUM ROBOTS - Methods and systems are described for controlling movement of a continuum robot that includes a plurality of independently controlled segments along the length of the continuum robot. The continuum robot is inserted into a cavity of unknown dimensions or shape. A plurality of forces acting upon the continuum robot by the surrounding cavity are estimated. A positioning command indicating a desired movement of the distal end of the continuum robot is received from a manipulator control. The desired movement is augmented based, at least in part, on the estimated plurality of forces acting on the continuum robot such that movement is restricted to within safe boundaries of the surrounding cavity. The positioning of the continuum robot is then adjusted based on the augmented desired movement. | 11-06-2014 |
20140329092 | MATERIALS COMPRISING DEAGGREGATED DIAMOND NANOPARTICLES - Heat-transfer fluids and lubricating fluids comprising deaggregated diamond nanoparticles are described herein. Also described are composites comprising deaggregated diamond nanoparticles, and methods of making such composites. Method of using deaggregated diamond nanoparticles, for example, to improve the properties of materials such as thermal conductivity and lubricity are also disclosed. | 11-06-2014 |
20140322219 | ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF - The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier. Methods of the invention comprise administering the compositions described above to a subject in need thereof for the purpose of inhibiting thrombosis, reducing a required dose of an antithrombotic agent in the treatment of thrombosis, treating metastatic cancer, or treating an acute inflammatory reaction. | 10-30-2014 |
20140316434 | SYSTEMS AND METHODS FOR ROBOT-ASSISTED TRANSURETHRAL EXPLORATION AND INTERVENTION - Systems and methods are described for using a robotic system to perform procedures within a cavity using a virtual fixture. The robotic system includes a rigid central stem including an access channel positioned longitudinally along the rigid central stem and a dexterous arm at least partially positioned within the access channel of the central stem. The dexterous arm includes a plurality of individually adjustable segments. A control system receives a positioning command from a manipulator control indicative of a desired movement of a distal end of the dexterous arm. A virtual fixture is defined that is representative of the access channel of the rigid central stem. The position of the dexterous arm is adjusted such that the distal end of the dexterous arm performs the desired movement while the portion of the dexterous arm that is positioned within the first access channel is not moved beyond the defined virtual fixture. | 10-23-2014 |
20140309159 | COMPOSITIONS AND METHODS FOR TARGETING NUCLEAR IMPORT SHUTTLES AND TREATING INFLAMMATORY DISORDERS - The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (NTM) and/or at least one importin alpha-selective NTM, and/or at least one importin alpha-specific NTM, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation. | 10-16-2014 |
20140308202 | NF-KB GENE SIGNATURE PREDICTS PROSTATE AND BREAST CANCER PROGRESSION - The present invention is drawn to methods of assessing hormonally-regulated cancers such as prostate and breast, by examining the expression of particular genes disregulated in this disease state. | 10-16-2014 |
20140306575 | ENHANCED THERMIONIC ENERGY CONVERTER AND APPLICATIONS OF SAME - In one aspect of the invention, a thermionic energy converter comprises an anode, a cathode spaced from the anode to define a gap therebetween, and molecular hydrogen incorporated into the gap. | 10-16-2014 |
20140300353 | QUANTIFYING BREAST TISSUE CHANGES WITH SPECTRALLY SELECTIVE MRI AND MRS - Systems and methods for magnetic resonance analysis and imaging are provided. IN particular, pulse sequences for DWI, APT, and MRS analysis and imaging are provided which rely on an RF excitation pulse for the signal of interest, followed by one or more refocusing pulses and acquisition steps, based on the type of imaging. | 10-09-2014 |
20140288084 | SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 - In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 09-25-2014 |
20140277105 | MATERIAL MANIPULATION METHOD AND APPARATUS - A method and apparatus for use in manipulating material during a medical procedure includes positioning the material in engagement with a major side surface on a distal end portion of a shaft. A gripper is operated to grip the material between a wire and a major side surface of the shaft by moving the wire along a longitudinal central axis of the shaft. Material is moved to a desired position relative to a patient's body while the material is gripped between the wire and the major side surface of the distal end portion of the shaft. The wire is then retracted along the longitudinal central axis of the shaft to release the material for movement relative to the end distal end portion of the shaft. | 09-18-2014 |
20140276586 | STEERABLE SURGICAL NEEDLE - A steerable surgical needle ( | 09-18-2014 |
20140272937 | Low Resource Processor Using Surface Tension Valves for Extracting, Concentrating, and Detecting Whole Cells - Systems and methods are described for isolation, separation and detection of a molecular species using a low resource device for processing of samples. Methods include isolation, separation and detection of whole cells. | 09-18-2014 |
20140271665 | Combinations of Kinase Inhibitors for the Treatment of Cancer - The present invention provides methods of treating cancer by administering a compound of formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with an inhibitor that targets HER2 and/or HER3. | 09-18-2014 |
20140256774 | METHODS FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS - A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound. | 09-11-2014 |
20140256720 | CANCER TREATMENT USING BMP INHIBITOR - Methods for regulating cancer cell growth and survival, inhibiting cancer cell growth, promoting cancer cell death, and/or treating a cancer make use of antagonists of a type I BMP receptor. In some embodiments the cancer is a lung cancer and the cancer cell is a lung cancer cell. | 09-11-2014 |
20140242135 | COMPOSITIONS FOR INHIBITION OF INSECT SENSING - In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitos. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 08-28-2014 |
20140221908 | SURFACTANT PORTED DEVICE FOR TREATMENT OF BLEPHARITIS AND APPLICATIONS OF SAME - Certain aspects of the present disclosure are directed to a system for treating a gland of a patient. The system includes a handheld device including a probe, a tip of the probe being formed with a suction opening and a delivery opening; a backend apparatus including a fluid reservoir configured to contain a fluid, an agent reservoir configured to contain agent particles, and a suction force generator; a delivery channel in fluid communication with the delivery opening and the fluid reservoir and the agent reservoir, the delivery channel allowing a mixture of the fluid and the agent particles to travel through the delivery channel and exit at the delivery opening; and a suction channel in fluid communication with the suction opening and the suction force generator, the suction channel allowing a suction force being generated at the suction opening by the suction force generator. | 08-07-2014 |
20140221826 | OPTICAL COHERENCE TOMOGRAPHY PROBE - A miniature intraoperative probe ( | 08-07-2014 |
20140220690 | MAMMALIAN GENES INVOLVED IN INFECTION - The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens. | 08-07-2014 |
20140220547 | Methods and Compositions for Vein Harvest and Autografting - The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided. | 08-07-2014 |
20140219965 | CONTROLLING APPETITE, PROMOTING WEIGHT LOSS, REDUCING BODY FAT, AND/OR IMPROVING GLUCOSE TOLERANCE - A method for treating obesity, insulin sensitivity, and related conditions involves administering to the subject a bacterium for overexpressing a N-acyl-phosphatidylethanolamine (NAPE) and/or a N-acylethanolamine (NAE). A composition includes a bacterium for overexpressing a N-acyl-phosphatidylethanolamine (NAPE) and/or a N-acylethanolamine (NAE); and an ingestible vehicle in which the bacterium is provided. | 08-07-2014 |
20140207062 | APPARATUS AND METHODS FOR MEASURING PERIPHERAL VENOUS PRESSURE AND APPLICATIONS OF SAME - In one aspect, an apparatus for measuring peripheral venous pressure includes a tubing having two ends with one end connectable to a fluid source and the other end connectable to a vein, a fluid controlling device configured to have an on position and an off position, and at least one pressure sensor configured to measure fluid pressures therein. When the fluid controlling device is in the on position, fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures both a fluid pressure from the fluid source and a distal venous pressure from the vein. When the fluid controlling device is in the off position, no fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures the distal venous pressure from the vein only. | 07-24-2014 |
20140206953 | SYSTEM AND METHOD FOR DETECTING TISSUE SURFACE PROPERTIES - A system and method for detecting a tissue property. The system comprises a first unit positioned outside a patient body and a second unit positioned inside the patient's body. The first unit includes a first housing, and a magnetic field source supported by the first housing. The second unit includes a second housing, a pressure sensor supported by the second housing, a localization module supported by the second housing, a controller, and a power source. The pressure sensor is configured to detect an indentation force applied to the tissue, and the second unit is configured to wirelessly transmit the indentation force data and localization data to a computer to generate a volumetric stiffness map for the tissue. | 07-24-2014 |
20140206707 | 6-ALKYL-N-(PYRIDIN-2-YL)-4-ARYLOXYPICOLINAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-24-2014 |
20140206676 | SUBSTITUTED 4-(1H-PYRAZOL-4-YL)BENZYL ANALOGUES AS POSITIVE ALLOSTERIC MODULATORS OF MACHR M1 RECEPTORS - In one aspect, the invention relates to substituted 4-(1H-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 07-24-2014 |
20140195007 | POWERED LEG PROSTHESIS AND CONTROL METHODOLOGIES FOR OBTAINING NEAR NORMAL GAIT - A powered leg prosthesis includes powered knee joint comprising a knee joint and a knee motor unit for delivering power to the knee joint. The prosthesis also includes a prosthetic lower leg having a socket interface coupled to the knee joint and a powered ankle joint coupled to the lower leg opposite the knee joint comprising an ankle joint and an ankle motor unit to deliver power to the ankle joint. The prosthesis further includes a prosthetic foot coupled to the ankle joint, at least one sensor for measuring a real-time input, and at least one controller for controlling movement of the prosthesis based on the real-time input. | 07-10-2014 |
20140194471 | SUBSTITUTED 1-BENZYLINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYLCHOLINE M1 RECEPTORS - In one aspect, the invention relates to substituted 1-benzylindolin-2-one analog compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 07-10-2014 |
20140186250 | CARBONYL FUNCTIONALIZED POROUS INORGANIC OXIDE ADSORBENTS AND METHODS OF MAKING AND USING THE SAME - An adsorbent material comprising a porous inorganic oxide material grafted with a molecule comprising a carbonyl functional group is provided. The porous inorganic oxide material can be a porous silica material or Zr(OH) | 07-03-2014 |
20140163537 | APPARATUS AND METHOD FOR REAL-TIME IMAGING AND MONITORING OF AN ELECTROSURGICAL PROCEDURE - An optical coherence tomography probe and laser combination device configured for real-time z-directional guidance of the incisional depth of a surgical procedure. It can be used alone or placed within the working channel of an endoscope. The device includes an OCT single mode fiber, and a laser fiber or laser hollow waveguide or electrical surgical wire positioned adjacent to the OCT single mode fiber. The single mode fiber is configured to move laterally when activated by an actuator to scan light data reflected from a sample that is positioned in front of a distal end of the device. The light data can be processed to generate a B-scan image. The device can collect data in real-time during lasing, or immediately prior to and following the cutting. The surgical tool, when coupled to a processor, can deactivate when the B-scan image identifies that the incision is within a predefined tolerance. | 06-12-2014 |
20140158922 | SOLENOID VALVE ASSEMBLY - A solenoid valve including a spool received within a housing. The spool is configured to move to multiple positions within the housing. The housing includes supply ports, exhaust ports, and outlet ports. When the spool is in a specific location, two outlet ports are in fluid communication with each other. | 06-12-2014 |
20140148357 | Characterizing Gastro-Intestinal Disease - A method for characterizing a gastro-intestinal disease in a subject involves comparing ratios of expression levels of genes in a biological sample from a subject to references, wherein the gastro-intestinal disease is characterized based on a difference in the ratios of the expression values of genes in the biological sample from the subject as compared to the references. | 05-29-2014 |
20140142475 | MOVEMENT ASSISTANCE DEVICE - A apparatus includes an a exoskeleton system with a plurality of sensors for generating signals indicating a current motion and a current arrangement of at least the exoskeleton system, a hip segment, and at least one lower limb. The lower limb includes thigh and shank segments for coupling to a lateral surface of a user's leg. The thigh segment includes a first powered joint coupling the thigh segment to the hip segment, a second powered joint coupling the thigh segment to the shank segment, and a controller coupled to the sensors, the first powered joint, and the second powered joint. The controller is configured for determining a current state of the exoskeleton system and a current intent of the user based on the signals and generating control signals for the first and second powered joints based on the current state and the current intent. | 05-22-2014 |
20140140594 | METHODS AND SYSTEMS FOR THREE-DIMENSIONAL REAL-TIME INTRAOPERATIVE SURGICAL MARGIN EVALUATION OF TUMOR TISSUES - In one aspect, the present invention relates to a system evaluating a surgical margin of tumor tissues of a living subject. In one embodiment, the system includes a light source configured to emit a source light; at least one optical probe; a scanner; a spectrometer; and a controller coupled with the scanner and the spectrometer for operably controlling the scanner and the spectrometer. In operation, a working end of the optical probe is positioned proximate to a surface of a specimen of the tumor tissues. A source channel of the optical probe deliver the source light emitted by the light source from the working end to the surface of the specimen, and a plurality of collection channels collect from the working end diffused/reflected light generated from interaction of the source light with the specimen. The spectrometer receives the collected diffused/reflected light to evaluate a margin status of the specimen. | 05-22-2014 |
20140135276 | LIPOPEPTIDE INHIBITORS OF RAS ONCOPROTEINS - The invention provides a peptide or peptidomimetic that is derived from or based upon the amino acid sequence of the C-terminal α-helix or hypervariable region (HVR) or a Ras protein, a nucleic acid encoding the peptide or peptidomimetic, and methods employing the same. | 05-15-2014 |
20140134154 | Immunological Compositions as Cancer Biomarkers and/or Therapeutics - The present invention concerns antibodies that react immunologically with anti-tumor antigen antibodies and compositions and methods related thereto. In particular, the antibodies that react immunologically with the anti-tumor antigen antibodies are employed in therapeutic, diagnostic, and prognostic embodiments related to cancer, including breast cancer, for example. | 05-15-2014 |
20140132265 | MULTIPLE RESONANCE NMR SPECTROSCOPY USING A SINGLE TRANSMITTER - An NMR imaging system comprising a transceiver module configured to couple with a magnetic resonance transmitter coil, where the transceiver module includes a first transmitter channel and a pulse programmer configured to control the transceiver module, the transceiver module generating a precession and nutation for observing rotation at multiple intervals about the carrier (“PANORAMIC”) waveform, the PANORAMIC waveform configured to produce nuclear polarization. The PANORAMIC waveform may a single-banded PANORAMIC waveform or a multiple-banded PANORAMIC waveform. A method of NMR spectroscopy or imaging, the method comprising: determining for a nuclear spin rotation at least one frequency interval and at least one corresponding phase; creating a PANORAMIC waveform for the at least one frequency interval and the at least one corresponding phase; and applying the PANORAMIC waveform from an amplifier output to a probe input. The PANORAMIC waveform may be a single-banded PANORAMIC waveform or a multiple-banded PANORAMIC waveform. | 05-15-2014 |
20140114438 | POWERED LEG PROSTHESIS AND CONTROL METHODOLOGIES FOR OBTAINING NEAR NORMAL GAIT - A powered leg prosthesis includes powered knee joint comprising a knee joint and a knee motor unit for delivering power to the knee joint. The prosthesis also includes a prosthetic lower leg having a socket interface coupled to the knee joint and a powered ankle joint coupled to the lower leg opposite the knee joint comprising an ankle joint and an ankle motor unit to deliver power to the ankle joint. The prosthesis further includes a prosthetic foot coupled to the ankle joint, at least one sensor for measuring a real-time input, and at least one controller for controlling movement of the prosthesis based on the real-time input. | 04-24-2014 |
20140107292 | COPOLYMERS AND METHODS OF USE THEREOF - Copolymers, such as block copolymers, having at least one block that is a random copolymer of ε-caprolactone and a-carboxy-s-caprolactone are disclosed. Also described are methods of using such copolymers, such as, for example, in medical devices. | 04-17-2014 |
20140086905 | IMMUNOLOGICAL COMPOSITIONS AS CANCER THERAPEUTICS - The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves. | 03-27-2014 |
20140081169 | SYSTEM AND METHOD OF TETHERLESS INSUFFLATION IN COLON CAPSULE ENDOSCOPY - A system and method of wireless controlled CO | 03-20-2014 |
20140081120 | SYSTEM AND METHOD FOR DETECTING TISSUE SURFACE PROPERTIES - A system and method of detecting and assessing a tissue surface property without a separate access port to internal anatomical structures. The system includes a first unit positioned outside the patient's body and a second unit positioned inside the patient's body. The first unit includes a magnetic field source and a force sensor and is positioned outside the patient's body in a position that enables magnetic coupling with the second unit, which is inside the patient's body. The second unit includes a magnetic field source, a processor, a sensor, a telemetry unit, a power source, and an optional actuator or other components. The resulting attractive force between the internal and external magnetic field sources can be perceived by the force sensor of the first unit. By varying the distance between the two units, the attractive force triggers a variable stress on the tissue surrounding the second unit in the direction of the magnetic field source in the first unit. | 03-20-2014 |
20140074176 | METHOD AND APPARATUS FOR SELECTIVELY CONTROLLING NEURAL ACTIVITIES AND APPLICATIONS OF SAME - In one aspect of the present invention, a method of transient and selective suppression of neural activities of a target of interest, such as one or more nerves, includes selectively applying at least one light to the target of interest at selected locations with predetermined radiant exposures to create a localized and selective inhibitory response therein. The localized and selective inhibitory response comprises a local temperature change. | 03-13-2014 |
20140073973 | INTRAVENOUS ACCESS DEVICE HAVING INTEGRATED HEMODYNAMIC RESUSCITATION SYSTEM AND RELATED METHODS - One aspect of the present disclosure is a system for hemodynamic resuscitation. The system includes an intravenous access device having a pressure sensor element configured to detect a peripheral venous pressure value in response to an occlusion of a peripheral vein. The system also includes a controller device that is configured to receive a signal from the pressure sensor comprising the peripheral venous pressure value, to process the signal to determine a hemodynamic parameter based on the peripheral venous pressure value, and to generate a resuscitation score based on the hemodynamic parameter. | 03-13-2014 |
20140065640 | Interferometric Detection Using Nanoparticles - This invention provides methods and systems for detecting interaction between members of a binding pair. The method involves associating one member of the binding pair with a nanoparticle and detecting the interaction between the two molecules by back-scattering interferometry. | 03-06-2014 |
20140065299 | ELECTRODE USEABLE IN ELECTROCHEMICAL CELL AND METHOD OF MAKING SAME - A method of making an electrode useable in an electrochemical cell, includes the steps of (a) providing an electrically conductive substrate; (b) forming nanostructured current collectors on the conductive substrate; and (c) attaching nanoparticles of a ternary orthosilicate composite to the nanostructured current collectors. The ternary orthosilicate composite includes Li | 03-06-2014 |
20140057870 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 02-27-2014 |
20140051972 | DRUG DELIVERY DEVICE AND APPLICATIONS OF SAME - A drug delivery device includes a catheter having first and second ends; a flexible membrane having a rim securely connected to an inner surface of the catheter to define a first volume between the first end and the flexible membrane, and a second volume between the flexible membrane and the second end, such that the second volume is substantially the same as a desired drug volume; and a pressurizable member coupled to the catheter for operably delivering a drug. In use, a desired volume of the drug is preloaded into the second volume of the catheter that in turn is slid into a guidance device, when the guidance device is placed in a target of interest, the pressurizable member applies a pressure into the first volume to exert a force upon the flexible membrane to operably squeeze the second volume, thereby unloading the drug into the target. | 02-20-2014 |
20140046083 | Enhancement of Light Emission Quantum Yield in Treated Broad Spectrum Nanocrystals - Inorganic photoluminescent nanoparticles comprising a solid assembly comprising a first plurality of atoms from group II crystallized with a second plurality of atoms from group VI; at least one dimension of the assembly less than about 3.0 nm; and one or more organocarboxylate agents coupled to a surface that bounds the assembly, wherein the nanocrystal exhibits nanocrystal photoluminescence quantum yield of at least about 10%. Coupling to such surface comprises coating at least a portion of the nanocrystal being coated with the organocarboxylate agent, wherein the organocarboxylate agent is a carboxylic acid or the conjugate base of a carboxylic acid. The carboxylic acid can be is selected from formic acid, acetic acid, hexanoic acid, octanoic acid, oleic acid, and benzoic acid. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 02-13-2014 |
20140044673 | Classifying Skin Lesions Using Mass Spectrometry Proteomic Approach - The present invention provides for a mass spectrometry proteomic approach to distinguishing Spitz nevi from Spitzoid malignant melanoma. Histology directed mass spectral profiling allows for targeted analysis of sites of melanocytic lesion within formalin-fixed, paraffin embedded excisional biopsies. The classification system identified 5 peptide peaks, of which two have been identified as originating from vimentin and actin. A sensitivity and specificity for Spitz nevi of 97% and 90%, respectively, were achieved. | 02-13-2014 |
20140042407 | BIOHYBRID PHOTOELECTROCHEMICAL ENERGY CONVERSION DEVICE - One aspect of the present disclosure relates to a biohybrid, photoelectrochemical energy conversion device including a first electrode, a second electrode, and a multilayer photoconductive organic film interposed between the first and second electrodes. The second electrode is formed from a semiconductor material. Each layer of the photoconductive organic film includes at least one light harvesting complex. | 02-13-2014 |
20140038076 | NANOFIBER MEMBRANE-ELECTRODE-ASSEMBLY AND METHOD OF FABRICATING SAME - In one aspect of the present invention, a fuel cell membrane-electrode-assembly (MEA) has an anode electrode, a cathode electrode, and a membrane disposed between the anode electrode and the cathode electrode. At least one of the anode electrode, the cathode electrode and the membrane is formed of electrospun nanofibers. | 02-06-2014 |
20140037161 | ENHANCED METHOD FOR CORRECTING DATA FOR DEFORMATIONS DURING IMAGE GUIDED PROCEDURES - Systems and methods are provided for collecting and processing physical space data for use while performing an image-guided surgical (IGS) procedure. A method includes performing a rigid alignment of a computer model of a non-rigid structure of interest in a patient and surface data in a patient space associated with at least a portion of said non-rigid structure, and computing a deformation of the computer model that provides a non-rigid alignment of said computer model and an organ geometric representation of data, said deformation computed using a set of boundary conditions and field variables defined for said computer model based on said rigid alignment and a parameterization function. | 02-06-2014 |
20140034481 | PARA-HYDROGEN POLARIZER - A reactor assembly comprising a reservoir, a reaction chamber, and a valve assembly comprising at least one valve. The reservoir, reaction chamber, and valve assembly are non-magnetic. The valve assembly is adapted to selectively provide fluid communication between the reservoir and the reaction chamber. | 02-06-2014 |
20140024902 | SYSTEM AND METHODS FOR OPTICAL STIMULATION OF NEURAL TISSUES - The present invention, in one aspect, relates to a system for stimulating neural tissue of a living subject. The system comprises an energy source capable of generating optical energy, a connector having a first end and a second end capable of transmitting optical energy, and a probe operably coupled to the second end of the connector and having an end portion for delivering optical energy to a target neural tissue. In one embodiment, the energy source comprises a tunable laser. | 01-23-2014 |
20140005278 | LINEAR POLYESTER AND SEMI-LINEAR GLYCIDOL POLYMER SYSTEMS: FORMULATION AND SYNTHESIS OF NOVEL MONOMERS AND MACROMOLECULAR STRUCTURES | 01-02-2014 |
20130338154 | MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION - Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 12-19-2013 |
20130324914 | SWALLOWABLE CAPSULE FOR INSUFFLATION OF GASTROINTESTINAL TRACT - A system for insufflating a body cavity comprising a swallowable capsule comprising a chamber ( | 12-05-2013 |
20130323244 | COMPOSITIONS COMPRISING ALKALINE PHOSPHATASE AND/OR NATRIURETIC PEPTIDE AND METHODS OF USE THEREOF - The present invention provides methods, compositions, and kits for the treatment of neurocutaneous syndromes, such as neurofibromatosis type I; disorders associated with overactivation of FGFR3, such as achondroplasia; bone or cartilage disorders; or vascular smooth muscle disorders; or for the elongation of bone. In some embodiments, the present invention provides polypeptides having an alkaline phosphatase peptide fused to an Fc domain of an immunoglobulin or a natriuretic peptide fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to subjects, e.g., subcutaneously, to treat a neurocutaneous syndrome, a disorder associated with overactivation of FGFR3, a bone or cartilage disorder, or a vascular smooth muscle disorder, or to elongate bone. The invention also features nucleic acid molecules encoding such polypeptides and the use of the nucleic acid molecules for treating neurocutaneous syndromes, disorders associated with overactivation of FGFR3, bone or cartilage disorders, or vascular smooth muscle disorders, or for elongating bone. | 12-05-2013 |
20130310949 | STAIR ASCENT AND DESCENT CONTROL FOR POWERED LOWER LIMB DEVICES - Systems and methods of operating a lower limb device having at least a powered joint are provided. A method includes configuring the device to a first state in a finite state model for a current activity mode including a stair ascent mode or a stair descent mode. The method also includes, based on real-time sensor information, transitioning the device between different states in the finite state model when pre-defined criteria for transitioning among the different states are met. In the method, the finite state model for stair ascent includes lifting and swing phases, where the lifting phase includes a powered knee extension and a powered ankle push-off. The finite state model for stair descent includes yielding and swing states, where the swing states include providing a powered plantarflexion of the powered ankle joint and the yielding states include providing a resistive and passive plantarflexion of the powered ankle joint. | 11-21-2013 |
20130309661 | FREE SOLUTION MEASUREMENT OF MOLECULAR INTERACTIONS BY BACKSCATTERING INTERFEROMETRY - Disclosed are methods, systems, and apparatuses for the free solution measurement of molecular interactions by backscattering interferometry. In one aspect, the invention relates to method and systems for detecting molecular interaction between analytes in free-solution wherein the analytes are label-free and detection is performed by back-scattering interferometry. Also disclosed are label-free, free-solution, and/or real-time measurements of characteristic properties and/or chemical events using the disclosed techniques. The disclosed methods can have very low detection limits and/or very low sample volume requirements. Also disclosed are various biosensor applications of the disclosed techniques. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 11-21-2013 |
20130300537 | METHOD AND SYSTEM FOR CONTACT DETECTION AND CONTACT LOCALIZATION ALONG CONTINUUM ROBOTS - A robotic system and methods for manipulation of multi-segment continuum robots. The methods relate to contact detection and estimation of contact location along a multi-segment continuum robot. | 11-14-2013 |
20130295590 | FOXA1 AS A MARKER FOR INVASIVE BLADDER CANCER - The present invention provides for a proteomic approach to predicting, diagnosing and staging invasive bladder cancer, and for predicting patient survival and therapeutic efficacy. More specifically, the target being analyzed for reduced expression is FOXA1, and optionally including analysis of increased FOXA2 expression. | 11-07-2013 |
20130289246 | INFLUENZA VIRUS ANTIBODIES AND IMMUNOGENS AND USES THEREFOR - The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of influenza virus infections. In particular, these antibodies may neutralize or limit the replication of influenza virus. Also disclosed are improved methods for producing such monoclonal antibodies, including novel immunogens for use in vaccination and production of protective immune responses. | 10-31-2013 |
20130287613 | PERISTALTIC MICROPUMP AND RELATED SYSTEMS AND METHODS - A peristaltic micropump comprising one or more conduits configured to transfer one or more pumped fluids, wherein each conduit comprises: an inlet ( | 10-31-2013 |
20130280796 | POROUS MEMBRANE WAVEGUIDE SENSORS AND SENSING SYSTEMS THEREFROM FOR DETECTING BIOLOGICAL OR CHEMICAL TARGETS - A sensor for sensing at least one biological target or chemical target is provided. The sensor includes a membrane includes a membrane material that supports generation and propagation of at least one waveguide mode, where the membrane material includes a plurality of voids having an average size <2 microns. The sensor also includes at least one receptor having structure for binding to the target within the plurality of voids, and an optical coupler for coupling light to the membrane sufficient to generate the waveguide mode in the membrane from photons incident on the optical coupler. | 10-24-2013 |
20130280715 | Methods, Systems and Compositions for Nucleic Acid Analysis Using Back-Scattering Interferometry - Disclosed are methods, systems, and apparatuses for the measurement of hybridization of nucleic acid polymers or binding other biological molecular species such as proteins, enzymes, receptors, and antibodies to binding partners, by backscattering interferometry (BSI). | 10-24-2013 |
20130268090 | SYSTEM AND METHOD FOR PROVIDING BIOMECHANICALLY SUITABLE RUNNING GAIT IN POWERED LOWER LIMB DEVICES - Systems and methods for a running controller for a lower limb device including at least a powered knee joint are provided. The method includes collecting real-time sensor information for the lower limb device and configuring the lower limb device to a first state in a finite state model for an activity mode including the running mode. The method further includes, based on the sensor information, transitioning the lower limb device from a current state to a subsequent state in the finite state model for the detected mode when a pre-defined criteria for transitioning to the subsequent state is met, and repeating the transitioning until the activity mode changes. In the system and method, the finite state model includes at least one stance state and at least one swing state, where the at least one stance state includes at least one absorption state and at least one propulsion state. | 10-10-2013 |
20130261107 | BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to novel bicyclic oxazole and thiazole compounds which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions; and methods for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 10-03-2013 |
20130253705 | CONTROL SYSTEM FOR A GRASPING DEVICE - A method for operating a grasping device and grasping devices therefrom are provided. The grasping device is configured to use a plurality of parallel, bi-directional state flow maps each defining a sequence of poses for a plurality of joints in the grasping device. The method include receiving at least one control signal, determining a current pose of the grasping device within the one of the plurality of state flow maps currently selected for the grasping device, and selectively actuating the plurality of joints to traverse the sequence of poses, where a direction for traversing the sequence of poses is based on the at least one control signal. | 09-26-2013 |
20130251628 | LIGANDS TO RADIATION-INDUCED MOLECULES - A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands. | 09-26-2013 |
20130245725 | APPARATUS AND METHODS FOR OPTICAL STIMULATION OF NEURAL TISSUES - An apparatus for stimulating a neural tissue of a living subject. The neural tissue is characterized with a thermal diffusion time, T | 09-19-2013 |
20130236513 | Synthetic Polyurethane Composite - Embodiments of the present inventions comprise composites of polyurethane(s), osteoconductive matrix, and, optionally, a growth factor. Embodiments further comprise methods of making such composite and uses thereof. The osteoconductive matrix can be a tricalcium phosphate, bioglass, or the like, and can include particles that are surface modified. Growth factors can be provided in powder form, including bone morphogenic proteins such as rhBMP-2. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. | 09-12-2013 |
20130231683 | APPARATUS FOR SUPPORTING AN ADJUSTABLE SURGICAL PLATFORM - In one aspect, an apparatus for supporting an adjustable surgical platform is disclosed. In one embodiment, the apparatus includes a supporting platform portion with a body portion that defines bore along a central axis. Arm portions with engaging means extend radially from the supporting platform portion. The apparatus also includes a shaft portion extending from the supporting platform portion in a first direction, with a shaft body portion that defines a bore along a longitudinal axis B. The bore of the shaft body portion is in communication with the bore of the supporting platform portion. The apparatus further includes a base portion connected to the shaft portion, and that defines a bore in communication with the bore of the shaft portion and the bore of the supporting platform portion. Mounting means are configured to secure the base portion to a region of interest of a living subject. | 09-05-2013 |
20130228462 | DENSELY-PACKED FILMS OF LANTHANIDE OXIDE NANOPARTICLES VIA ELECTROPHORETIC DEPOSITION - A method of forming a film of lanthanide oxide nanoparticles. In one embodiment, the method includes the steps of: (a) providing a first substrate with a conducting surface and a second substrate that is positioned apart from the first substrate, (b) applying a voltage between the first substrate and the second substrate, (c) immersing the first and the second substrates in a solution that comprises a plurality of lanthanide oxide nanoparticles suspended in a non-polar solvent or apolar solvent for a first duration of time effective to form a film of lanthanide oxide nanoparticles on the conducting surface of the first substrate, and (d) after the immersing step, removing the first substrate from the solution and exposing the first substrate to air while maintaining the applied voltage for a second duration of time to dry the film of lanthanide oxide nanoparticles formed on the conducting surface of the first substrate. | 09-05-2013 |
20130217952 | OPHTHALMIC ORBITAL SURGERY APPARATUS AND METHOD AND IMAGE-GUIDED NAVIGATION SYSTEM - A flexible endoscope for ophthalmic orbital surgery includes a flexible probe housing having a proximal end, a distal end and a lumen extending between the proximal end and the distal end. The endoscope also includes an image fiber disposed in the lumen that communicates image information from the distal end of the flexible probe, a purge fluid/gas port disposed at the proximal end of the flexible probe that accepts purge fluid/gas and a purge fluid/gas conduit disposed in the lumen and in fluid communication with the purge fluid/gas port. The fluid/gas conduit delivers purge fluid/gas to the distal end of the endoscope. The endoscope also includes an access conduit disposed in the lumen that receives one of an ablation instrument, a coagulating instrument and a medication delivery instrument. | 08-22-2013 |
20130217917 | CHOLINE ANALOGS AND CHEMICAL SYNTHESIS THEREOF - A method of making a betaine aldehyde, comprising ozonizing an allyl trimethylammonium to form the betaine aldehyde. | 08-22-2013 |
20130210021 | Isolated Staphylococcus Pseudolugdunensis - Disclosed is an isolated strain of a previously unknown | 08-15-2013 |
20130209913 | NANOFIBER ELECTRODE AND METHOD OF FORMING SAME - In one aspect, a method of forming an electrode for an electrochemical device is disclosed. In one embodiment, the method includes the steps of mixing at least a first amount of a catalyst and a second amount of an ionomer or uncharged polymer to form a solution and delivering the solution into a metallic needle having a needle tip. The method further includes the steps of applying a voltage between the needle tip and a collector substrate positioned at a distance from the needle tip, and extruding the solution from the needle tip at a flow rate such as to generate electrospun fibers and deposit the generated fibers on the collector substrate to form a mat with a porous network of fibers. Each fiber in the porous network of the mat has distributed particles of the catalyst. The method also includes the step of pressing the mat onto a membrane. | 08-15-2013 |
20130208235 | ILLUMINATED LOW-VISION READER - A low-vision reader for individuals with low vision, includes a frame for supporting lenses, at least one oculus dexter lens supported by the frame on an oculus dexter side, and at least one oculus sinister lens supported by the frame on an oculus sinister side, and a pair of lights. Each of the lenses has an induced prism in a range between about 0 PD and about 22 PD and a lens power that is greater than about +4.00 diopters and less than +20.00 diopters such that each of the said lenses focused at a distance that is greater than about 5 cm and less than about 25 cm. Each light has a predetermined light strength is mounted adjacent the outer portions of the lenses and oriented to project light to provide a predetermined overlapping lighted area in a predetermined field. | 08-15-2013 |
20130197408 | MOVEMENT ASSISTANCE DEVICE - A apparatus includes an a exoskeleton system with a plurality of sensors for generating signals indicating a current motion and a current arrangement of at least the exoskeleton system, a hip segment, and at least one lower limb. The lower limb includes thigh and shank segments for coupling to a lateral surface of a user's leg. The thigh segment includes a first powered joint coupling the thigh segment to the hip segment, a second powered joint coupling the thigh segment to the shank segment, and a controller coupled to the sensors, the first powered joint, and the second powered joint. The controller is configured for determining a current state of the exoskeleton system and a current intent of the user based on the signals and generating control signals for the first and second powered joints based on the current state and the current intent. | 08-01-2013 |
20130183678 | LOW RESOURCE PROCESSOR USING SURFACE TENSION VALVES FOR EXTRACTING, CONCENTRATING AND DETECTING MOLECULAR SPECIES - Systems and methods are described for isolation, separation and detection of a molecular species using a low resource device for processing of samples. Methods include isolation, separation and detection of a molecular species for protein-protein, DNA-DNA and other chemical interactions. | 07-18-2013 |
20130182249 | NANOSCALE POROUS GOLD FILM SERS TEMPLATE - Provided are patterned nanoporous gold (“P-NPG”) films that may act as at least one of an effective and stable surface-enhanced Raman scattering (“SERS”) substrate. Methods of fabricating the P-NPG films using a low-cost stamping technique are also provided. The P-NPG films may provide uniform SERS signal intensity and SERS signal intensity enhancement by a factor of at least about 1×10 | 07-18-2013 |
20130180235 | Elastic Hydraulic Accumulator/Reservoir System - The invention is a combination accumulator and reservoir which stores energy when the accumulator deforms from its original shape in response to the flow of a pressurized fluid from the reservoir. The stored energy is returned when the fluid flow is reversed and the accumulator discharges the fluid and returns to its original shape. At least one part of the novelty of the invention is that the accumulator and the fluid reservoir reside in the same housing such that the volume of each varies inversely. Accordingly, the invention is more compact and weighs less than conventional accumulators. Another feature of the invention is that fluid is located around the bladder accumulator to lubricate contact between the bladder and sides of the reservoir. | 07-18-2013 |
20130178458 | SUBSTITUTED (1-(METHYLSULFONYL)AZETIDIN-3-YL)(HETEROCYCLOALKYL)METHANONE ANALOGS AS ANTAGONISTS OF MUSCARINIC ACETYLCHOLINE M1 RECEPTORS - In one aspect, the invention relates to substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs, derivatives thereof, and related compounds, which are useful as antagonists of the muscarinic acetylcholine receptor M | 07-11-2013 |
20130177502 | Targeted, NIR Imaging Agents for Therapy Efficacy Monitoring, Deep Tissue Disease Demarcation and Deep Tissue Imaging - Compounds and methods related to NIR molecular imaging, in-vitro and in-vivo functional imaging, therapy/efficacy monitoring, and cancer and metastatic activity imaging. Compounds and methods demonstrated pertain to the field of peripheral benzodiazepine receptor imaging, metabolic imaging, cellular respiration imaging, cellular proliferation imaging as targeted agents that incorporate signaling agents. | 07-11-2013 |
20130171144 | ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF - The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier. Methods of the invention comprise administering the compositions described above to a subject in need thereof for the purpose of inhibiting thrombosis, reducing a required dose of an antithrombotic agent in the treatment of thrombosis, treating metastatic cancer, or treating an acute inflammatory reaction. | 07-04-2013 |
20130165960 | System and Methods of Using Image-Guidance for Providing an Access to a Cochlear of a Living Subject - A system and methods for providing an access to a cochlea of a living subject. In one embodiment of the present invention, a method comprises the steps of operating a surgical instrument towards a region of interest of the living subject for opening an access to the cochlea of the living subject from the lateral edge of the skull of the living subject to the cochlea of the living subject, and intra-operatively monitoring at least a part of the surgical instrument so that the surgical instrument is operated substantially along a predetermined path. | 06-27-2013 |
20130158078 | Heterocyclic Sulfone MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction - Heterocyclic sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 06-20-2013 |
20130153073 | DISTRIBUTED PISTON ELASTOMERIC ACCUMULATOR - The present invention is a distributed piston elastomeric accumulator which stores energy when its elastomeric member stretches from its original length in response to the flow of a pressurized fluid. The stored energy is returned when the fluid flow is reversed and the accumulator discharges the fluid as its elastomeric member returns to its original length and moves the piston to its initial position. At least one part of the novelty of the invention is that the accumulator is not subject to radial strain gradients and the accumulator allows for precise pressure and linear position measurements. Accordingly, the invention allows for optimization of the energy strain storage capacity of a given elastomer. | 06-20-2013 |
20130143165 | PHOTOLITHOGRAPHED MICRO-MIRROR WELL FOR 3D TOMOGRAM IMAGING OF INDIVIDUAL CELLS - A micro-mirror well. In one embodiment the micro-mirror well includes a plurality of planar mirrors arranged around an axis of symmetry and inclined to form a pyramid well, where each of the plurality of planar mirrors is capable of reflecting light emitting from an object of interest placed inside the pyramid well. | 06-06-2013 |
20130142733 | MULTIFUNCTIONAL DEGRADABLE NANOPARTICLES WITH CONTROL OVER SIZE AND FUNCTIONALITIES - In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 06-06-2013 |
20130131868 | CONTINUUM ROBOTS AND CONTROL THEREOF - Method for controlling continuum robots and systems therefrom are provided. In the system and method, a new system of equations is provided for controlling a shape of the elastic member and a tension on a tendon applying a force to an elastic member of the robot. The system of equations can be used to estimate a resulting shape of the elastic member from the tension applied to the tendon. The system of equations can also be used to estimate a necessary tension for the tendon to achieve a target shape. | 05-23-2013 |
20130129745 | ANTI-FXI ANTIBODIES AND METHODS OF USE - Disclosed herein are monoclonal antibodies specific for factor XI (fXI) that prevent activation of fXI by factor XIIa (fXIIa). The monoclonal antibodies are universal fXI antibodies, capable of binding all mammalian species tested. The anti-fXI monoclonal antibodies prolong clotting time in mammalian plasmas. Moreover, administration of the fXI monoclonal antibodies disclosed herein results in inhibition of thrombosis without altering hemostasis in animal models of thrombosis. Thus, provided herein are monoclonal antibodies specific for fXI that block activation of fXI by fXIIa, compositions and immunoconjugates comprising such antibodies and their methods of use. | 05-23-2013 |
20130123236 | SUBSTITUTED BENZYLSPIROINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 - In one aspect, the invention relates to substituted benzylspiroindolin-2-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M | 05-16-2013 |
20130096110 | Pyrazolopyridine, Pyrazolopyrazine, Pyrazolopyrimidine, Pyrazolothiophene and Pyrazolothiazole Compounds as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction - Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 04-18-2013 |
20130089528 | COMPOSITIONS AND METHODS FOR PRESERVING INSULIN-PRODUCING CELLS AND INSULIN PRODUCTION AND TREATING DIABETES - Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.1 can result in lowering of blood glucose levels and may reducing insulin resistance, the compositions, methods and cells described herein can also be used for treating Type 2 diabetes (T2D). | 04-11-2013 |
20130079366 | Benzisoxazoles and Azabenzisoxazoles as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction - Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 03-28-2013 |
20130065929 | Use of Pyridoxamine to Treat and/or Prevent Disease Processes - Methods for treating and/or preventing at least one symptom of a disorder associated with oxidative stress, carbonyl stress, or combinations thereof in a subject. In some embodiments, the methods include administering to the subject an effective amount of pyridoxamine, an analog or derivative thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods for treating or preventing a nephropathy, acute renal injury, acute renal failure, or combinations thereof in a subject, and formulations adapted for intravenous administration comprising pyridoxamine, an analog or derivative thereof, or a pharmaceutically acceptable salt of any of the foregoing. | 03-14-2013 |
20130065895 | Pyrazolopyridine, Pyrazolopyrazine, Pyrazolopyrimidine, Pyrazolothiophene and Pyrazolothiazole Compounds as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction - Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 03-14-2013 |
20130063434 | APPARATUS AND METHODS OF COMPENSATING FOR ORGAN DEFORMATION, REGISTRATION OF INTERNAL STRUCTURES TO IMAGES, AND APPLICATIONS OF SAME - A method and system of compensation for intra-operative organ shift of a living subject usable in image guide surgery. In one embodiment, the method includes the steps of generating a first geometric surface of the organ of the living subject from intra-operatively acquired images of the organ of the living subject, constructing an atlas of organ deformations of the living subject from pre-operatively acquired organ images from the pre-operatively acquired organ images, generating a second geometric surface of the organ from the atlas of organ deformations, aligning the second geometric surface of the organ to the first geometric surface of the organ of the living subject to determine at least one difference between a point of the first geometric surface and a corresponding point of the second geometric surface of the organ of the living subject, which is related to organ shift, and compensating for the intra-operative organ shift. | 03-14-2013 |
20130052138 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 - The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity. | 02-28-2013 |
20130040944 | MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION - Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 02-14-2013 |
20130013030 | METHOD AND APPARATUS OF PULSED INFRARED LIGHT FOR THE INHIBITION OF CENTRAL NERVOUS SYSTEM NEURONS - Certain aspects of the present disclosure are directed to a method of applying infrared neural stimulation (INS) to the central nervous system (CNS) of a target. The methods includes applying a pulsed infrared laser at a stimulation site in the CNS; and evoking responses from a region of interest of the CNS that is at or adjacent to the stimulation site by the pulsed infrared laser. In the method, the pulsed infrared laser penetrates a predetermined penetration depth of the stimulation site. Certain aspects of the present disclosure are directed to an apparatus for applying INS to the CNS of a target. The apparatus includes a generator generating a pulsed infrared laser, which penetrates a predetermined penetration depth of a stimulation site to evoke a response from the CNS, and an optical medium adapted for delivering the pulsed infrared laser at the stimulation site of the CNS. | 01-10-2013 |
20120330635 | SYSTEM AND METHOD FOR CORRECTING DATA FOR DEFORMATIONS DURING IMAGE-GUIDED PROCEDURES - Systems and methods for collecting and processing physical space data for use while performing an image-guided surgical (IGS) procedure are provided. The system and method includes obtaining a computer model of a non-rigid structure of interest in a patient and performing a rigid alignment of the computer model and surface data in a patient space associated with at least a portion of the non-rigid structure. The system and method also include computing a deformation of the computer model that provides a non-rigid alignment of the computer model and surface data, the deformation computed using a set of boundary conditions defined for each node of the computer model based on the rigid alignment and a kernel function. Additionally, the system and method can include displaying data for facilitating the IGS procedure based on the deformation. | 12-27-2012 |
20120314542 | SYSTEM AND METHOD FOR ESTIMATING PROJECTILE TRAJECTORY AND SOURCE LOCATION - Systems and methods for estimating projectile trajectory and projectile source location are provided. A method for estimating location information associated with a supersonic projectile propelled from a source includes recording sound at a first location using a single microphone during travel of the supersonic projectile to produce an acoustic recording. The method further includes estimating a miss distance between the first location and a trajectory of the projectile based on the shockwave length. Locating a projectile source includes concurrently recording sound at multiple locations and generating data sets associated with the locations, each of the plurality of data sets including a miss distance, a range, a time of arrival of a muzzle blast from the source, and a time of arrival of a shockwave produced by the projectile. Additionally, the method includes calculating an approximate location of the source at each of the locations based on the data sets. | 12-13-2012 |
20120301781 | ELECTRODE USEABLE IN ELECTROCHEMICAL CELL AND METHOD OF MAKING SAME - In one aspect of the present invention, an electrode useable in an electrochemical cell includes an electrically conductive substrate, nanostructured current collectors in electrical contact with the conductive substrate, and nanoparticles of a ternary orthosilicate composite coated on the nanostructured current collectors. The ternary orthosilicate composite comprises Li | 11-29-2012 |
20120299221 | MAGNETIC REVERSIBLY ATTACHED TEMPLATE (MRAT) AND USES THEREFOR - The magnetic reversibly attached template (MRAT) are solid devices made of biocompatible material containing a magnetic material. These devices can be made in any shape using microfabrication, milling, and molding and can be positioned and secured using magnetic forces. The applications of the M RAT encompass the patterning of biological and non-biological materials including cells, nucleic acids, peptides, proteins, aqueous solutions, polymers, rubbers, and other reagents on solid surfaces. | 11-29-2012 |
20120276523 | LIQUID DROP DIAGNOSTIC ASSAYS - The present invention provides simple and inexpensive assays for the detection of virtually any analyte in any sample that is in liquid form or that can be solubilized. The assays utilize the fluid dynamics of drop evaporation whereby soluble materials, including analytes and particles binding thereto, are drawn to the edge of the drop and ultimately form a concentrated residual ring. The presence or absence of certain reagents can then be detected through a number of different approaches. | 11-01-2012 |
20120276112 | ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF - The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier. Methods of the invention comprise administering the compositions described above to a subject in need thereof for the purpose of inhibiting thrombosis, reducing a required dose of an antithrombotic agent in the treatment of thrombosis, treating metastatic cancer, or treating an acute inflammatory reaction. | 11-01-2012 |
20120245185 | ARYL AND HETEROARYL SULFONES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION - In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 09-27-2012 |
20120245153 | MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION - Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof. | 09-27-2012 |
20120225131 | Methods For Treating Type Diabetes With Brown Adipose Transplants - The present invention provides for methods of treating diabetes by providing to a subject brown adipose tissue. The tissue may be transplanted from a culture of the subject's own tissue (autograft) or from a donor. These methods can achieve normoglycemia and suppress hypergluconemia, and alleviate conditions associated with such, even in the absence of or at extremely low levels of adjunct insulin therapy, and without any appreciable increase in insulinogenesis. | 09-06-2012 |
20120221119 | SYSTEMS AND CONTROL METHODOLOGIES FOR IMPROVING STABILITY IN POWERED LOWER LIMB DEVICES - Systems and methods are provided for controlling a lower limb device having at least one powered joint. The method includes detecting a stumble event based on one or more sensor signals associated with an overall motion lower limb device, classifying the stumble event based on sensor signals following the sensor signals associated with the stumble event, and selecting a stumble recovery strategy for the lower limb device based on the classification of the stumble event. | 08-30-2012 |
20120211112 | MULTIPLE ACCUMULATOR SYSTEMS AND METHODS OF USE THEREOF - The invention is an accumulator system in which multiple elastomeric accumulators are attached in series or parallel in order to generate total differential pressure in excess of that generated in a non-series system. Also disclosed is a “stacked” accumulator system. The system stores energy when the accumulators deform from their original shape in response to the flow of a pressurized fluid. The stored energy is available for use when the fluid is released from the accumulators and the accumulators return to their original shape. | 08-23-2012 |
20120192979 | ELASTIC HYDRAULIC ACCUMULATOR/RESERVOIR SYSTEM - The invention is a combination accumulator and reservoir which stores energy when the accumulator deforms from its original shape in response to the flow of a pressurized fluid from the reservoir. The stored energy is returned when the fluid flow is reversed and the accumulator discharges the fluid and returns to its original shape. At least one part of the novelty of the invention is that the accumulator and the fluid reservoir reside in the same housing such that the volume of each varies inversely. Accordingly, the invention is more compact and weighs less than conventional accumulators. Another feature of the invention is that fluid is located around the bladder accumulator to lubricate contact between the bladder and sides of the reservoir. | 08-02-2012 |
20120188538 | COMMON DETECTOR FOR COMBINED RAMAN SPECTROSCOPY-OPTICAL COHERENCE TOMOGRAPHY - In one aspect of the present invention, an apparatus includes a first light source for generating a broadband light, and a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting the received broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, and a sample arm optically coupled to the beamsplitter and the second light source for combining the sample light and the monochromatic light, delivering the combined sample and monochromatic light to the target of interest, collecting a backscattering light and a Raman scattering light that are generated from interaction of the sample light and the monochromatic light with the target of interest, respectively, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path, and a single detector optically coupled to the beamsplitter for collecting the interference signal. | 07-26-2012 |
20120183622 | ENCAPSULATED CELLS AND COMPOSITES THEREOF - Embodiments of the present invention comprise biodegradable composites including a polyurethane component and cells encapsulated in gel beads, as well as methods of making such composite and uses thereof. In certain embodiments the gel beads are alginate beads. The composites may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength, supports the in-growth of cells, and/or delivers cells to particular tissues. Inventive composites have the advantage of being able to fill irregularly shaped implantation sites, deliver cells in a localized and noninvasive manner, and optimize cell proliferation and differentiation of delivered cells. | 07-19-2012 |
20120176627 | Temperature Stable Interferometer - This invention provides an interferometric detection device configured to maintain a temperature of a sensing area to within 20 m° C. of a first target temperature and to maintain a temperature of the medium within 500 m° C. of a second target temperature The device can do so under conditions in which ambient temperature changes from 0.1° C. to 5° C. over 5 minutes. | 07-12-2012 |
20120176580 | ELECTRONICS ASSEMBLY IN LOW-VISION READER - A low-version reader (LVR) includes a frame adapted to be worn by a person as well as first and second light sources supported by the frame and positioned to project light beams focusing on a working surface. The LVR also includes a first battery embedded in the frame and a first power-supply circuit that regulates power provided by the first battery to energize the first light source. The first battery is rechargeable and in electrical communication through a first discharge path with the first light source. The first discharge path allows the first battery to energize the first light source. A first charger receptacle in electrical communication through a first charge path with the first battery. The first charge path allows charging the first battery when a power charger is coupled with the first charger receptacle. | 07-12-2012 |
20120172845 | SIDE-DEPLOYED MEDICAL GUIDEWIRE TORQUER - A side-deployable medical guidewire or guide wire torquer, torque device or wire manipulator. The torquer comprises an elongate body comprising first and second halves having an outer surface and inner surfaces, wherein the first and second halves are coupled to one another such that the inner surfaces to mate with one another, and wherein the mated surfaces are substantially parallel to the longitudinally axis of the body; a plurality of wire retainers disposed on the inner surfaces of one or more of the first and second halves configured to engage a guidewire positioned between the halves; and a releasable lock mechanism configured to mechanical secure the first and second halves in the mated configuration | 07-05-2012 |
20120172750 | ACCESS CATHETER SYSTEM HAVING A PRECISELY POSTIONABLE NEEDLE TIP - An access catheter system, comprising a needle assembly comprising a needle having an elongate lumen configured to be substantially filled with a fluid. The system further comprises a fluid monitor configured to monitor a physical characteristic of fluid within the lumen, and configured to sense a change in the physical characteristic. An indicator provides a indication of the sensed change in the physical characteristic. | 07-05-2012 |
20120156763 | Apparatus and Methods for Using Biological Material to Discriminate an Agent - An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of a physical quantity related to at least one of the cellular physiological activities of the cell, and identifying the agent from the measured response. The method further includes the step of quantifying the agent from the measured response. | 06-21-2012 |
20120152845 | POROUS SILICA-METAL ORGANIC COMPOSITE ADSORBENTS AND METHODS OF MAKING AND USING THE SAME - An adsorbent material comprising a metal organic phase and a porous silica phase is provided. The adsorbent material can be a synthesized from at least one porous silica material, one or more metal ions, and at least one organic linker comprising one or more multidentate functional groups capable of forming coordinate bonds with the metal ions. The porous silica can be an ordered mesoporous silica material. Methods of making the adsorbent material and methods of removing molecules from a fluid using the adsorbent material are also provided. | 06-21-2012 |
20120150322 | JOINTED MECHANICAL DEVICES - A jointed mechanical device is provided. The device includes at least one element ( | 06-14-2012 |
20120150321 | CONTROL SYSTEM FOR JOINTED MECHANICAL DEVICES - Systems and methods for controlling jointed mechanical devices are is provided, where the device is controlled based on a topographic state ( | 06-14-2012 |
20120120226 | TRANSMISSION ELECTRON MICROSCOPY FOR IMAGING LIVE CELLS - In one aspect, the present invention relates to a microfluidic chamber. In one embodiment, the microfluidic chamber has a first sub-chamber and at least one second sub-chamber. The first sub-chamber has a first window and a second window. Both the first window and the second window are transparent to electrons of certain energies. The second window is positioned substantially parallel and opposite to the first window defining a first volume therebetween. The first window and the second window are separated by a distance that is sufficiently small such that an electron beam that enters from the first window can propagate through the first sub-chamber and exit from the second window. The at least one second sub-chamber is in fluid communication with the first sub-chamber and has a second volume that is greater than the first volume of the first sub-chamber. | 05-17-2012 |
20120089017 | LIGANDS TO RADIATION-INDUCED MOLECULES - A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands. | 04-12-2012 |
20120088791 | AMIDOBIPIPERIDINECARBOXYLATE M1 ALLOSTERIC AGONISTS, ANALOGS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME - In one aspect, the invention relates to compounds having a general structure: Formula (I) which are useful as allosteric agonists of the M | 04-12-2012 |
20120085449 | High Energy Density Elastic Accumulator and Method of Use Thereof - The invention is an accumulator which stores energy by deforming from its original shape in response to the flow of a pressurized fluid. The stored energy is returned when the fluid flow is reversed and the accumulator returns to its original shape. At least one part of the novelty of the accumulator is that it captures elastic strain energy of a stretched bladder, as opposed to relying on gases and metals for energy storage as is usually seen in conventional accumulators. | 04-12-2012 |
20120058109 | REELIN RESCUES COGNITIVE FUNCTION - Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, can be used to increase Reelin levels and/or signaling. | 03-08-2012 |
20120041685 | SYSTEM AND METHOD FOR ESTIMATING RADIATION DOSE AND DISTRIBUTION USING MEDIUM-DEPENDENT-CORRECTION BASED ALGORITHMS (MDC) - Systems and methods for accurately calculating radiation doses in biological tissues exposed to a radiation source are provided. In the systems and methods first, a radiation dose is computed to geometry of water equivalent medium of the biological tissues, expressed in computed tomography (CT) volumetric images. A Medium-Dependent-Correction factor that is a function of an effective bone depth matrix and the incident x-ray beam is obtained and tabulated. Using patient material and density data derived from CT images, the effective bone thickness can be calculated from a specific x-ray source. Finally, a Medium-Dependent-Correction factor that is a function of an effective bone depth matrix is used to accurately determine the radiation dose distributions to biological tissues. | 02-16-2012 |
20120029340 | SYSTEM AND METHOD FOR DETERMINING MECHANICAL PROPERTIES OF BONE STRUCTURES - Systems and methods for characterizing bone structures are provided for characterizing bone structures. In the system and method, one or more | 02-02-2012 |
20120022683 | LATERAL POSITION DETECTION AND CONTROL FOR FRICTION STIR SYSTEMS - An apparatus and computer program are disclosed for processing at least one workpiece using a rotary tool with rotating member for contacting and processing the workpiece. The methods include oscillating the rotary tool laterally with respect to a selected propagation path for the rotating member with respect to the workpiece to define an oscillation path for the rotating member. The methods further include obtaining force signals or parameters related to the force experienced by the rotary tool at least while the rotating member is disposed at the extremes of the oscillation. The force signals or parameters associated with the extremes can then be analyzed to determine a lateral position of the selected path with respect to a target path and a lateral offset value can be determined based on the lateral position. The lateral distance between the selected path and the target path can be decreased based on the lateral offset value. | 01-26-2012 |
20120021189 | Pre-coated surfaces for analysis - Sample preparation can be a tedious and time consuming task. For example, MALDI imaging of tissue samples can require the tedious process of hand or robotically spotting solutions containing chemical species referred to as “matrix” onto a tissue sample prior its mass spectral analysis. Provided is a process for preparing a sample comprising immersing a solid support that has a surface comprising a first part that is more hydrophilic than a second part into a target compound solution, wherein the target compound is deposited primarily onto the more hydrophilic part; and/or applying and evaporating the target compound solution onto the substrate to produce the pre-coated substrate. A tissue or other sample may then be placed on the substrate for analysis. | 01-26-2012 |
20120016256 | APPARATUS AND METHOD FOR DETECTING AND MEASURING CONDITION OF ESOPHAGEAL MUCOSA AND INDICATIONS OF GASTROESOPHAGEAL REFLUX DISEASE - A mucosal impedance measuring system that is capable of direct and accurate impedance measurements of esophageal mucosa includes example multi-channel intraluminal impedance catheters with inflatable and deflatable components for positioning the impedance sensor electrodes in direct contact with the esophageal mucosa on the inside surface of the esophagus. Impedance measurements from multiple locations in the esophagus are processed for indications of mucosal damage that are indicative of damage due to gastrointestinal reflux disease (GERD), non-erosive reflux disease (NERD), and Barrett's esophagus. | 01-19-2012 |
20120015428 | METERING ROTARY NANOPUMP, METHOD OF FABRICATING SAME, AND APPLICATIONS OF SAME - In one aspect of the present invention, a pump includes a cam having a cam shaft, wherein the cam shaft has an axis, an exterior surface and M fins spaced-apart formed on the exterior surface along the axis; and at least one fluidic flow channel having an inlet and an outlet, disposed on a substrate, wherein the at least one fluidic flow channel helically surrounds the cam shaft such that when the cam shaft driven by the cam rotates, the M fins of the cam shaft compresses the at least one fluidic flow channels to produce a wave of compression that actuates a peristaltic flow of fluid therein so as to direct a desired amount of the fluid toward one of the inlet and the outlet. | 01-19-2012 |
20120015376 | Free Solution Measurement Of Molecular Interactions By Backscattering Interferometry - Disclosed are methods, systems, and apparatuses for the free solution measurement of molecular interactions by backscattering interferometry (BSI). Molecular interaction can be detected between analytes in free-solution wherein at least one of the analytes is label-free and detection is performed by back-scattering interferometry. Further, molecular interaction can be detected between analytes in free-solution, wherein at least one of the analytes is label-free, wherein one of the analytes is present in a concentration of less than about 5.0×10 | 01-19-2012 |
20120010601 | ORTHOPEDIC CEMENT AND USE OF SAME IN RADIATION THERAPY - A method of treating diseased tissue in a patient, the diseased tissue being proximate a hardened previously implanted bone cement including relatively high atomic number elements in a patient. The method includes generating a photon beam and directing the generated photon beam into the patient in a direction such that at least a portion of the photon beam impinges on the hardened bone cement and generates Compton interaction knock-out electrons from the high atomic number elements included in the hardened bone cement as a result of interaction of the at least a portion of the photon beam with the bone cement, wherein the direction of the photon beam is such that the at least a portion of the photon beam impinges on the hardened bone cement so that at least some of the Compton interaction knock-out electrons impinge upon the diseased tissue. | 01-12-2012 |
20120010483 | INTRA-OPERATIVE USE OF FLUORESCENCE SPECTROSCOPY AND APPLICATIONS OF SAME - In one aspect, the present invention relates to a process for intra-operatively providing anatomical guidance in endocrine surgery. In one embodiment, the process includes the steps of illuminating tissues in the neck area of a living subject with a beam of light having a predetermined wavelength, obtaining Raman data from light scattered from the illuminated tissues, finding Raman signatures corresponding to thyroid or parathyroid tissues from the obtained Raman data, and identifying the thyroid or parathyroid tissues from the corresponding Raman signatures. | 01-12-2012 |
20120004736 | SYSTEMS AND METHOD FOR VOLITIONAL CONTROL OF JOINTED MECHANICAL DEVICES BASED ON SURFACE ELECTROMYOGRAPHY - Systems and methods for controlling a weight bearing member having at least one powered joint are provided. A system includes a velocity reference module for receiving myoelectric control signals from a user during a non-weight bearing mode for the powered joint and generating a velocity reference for the powered joint based on the myoelectric control signals. The system further includes a volitional impedance module for generating a torque control signal for actuating the powered joint based at least on the velocity reference. | 01-05-2012 |
20120003729 | CAPILLARY PERFUSED BIOREACTORS WITH MULTIPLE CHAMBERS - A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel. | 01-05-2012 |
20110319913 | APPARATUS AND METHODS FOR PERCUTANEOUS COCHLEAR IMPLANTATION - A method and apparatus of percutaneous cochlear implantation (PCI). In one embodiment, the method includes the steps of (a) implanting a plurality of anchor members in a skull of a patient surrounding an ear of the patient, (b) attaching a docking frame to the plurality of anchor members, wherein the docking frame has a docking platform and a plurality of fiducial members, (c) acquiring a computed-tomography (CT) image of an area of the patient's head including the ear and the plurality of fiducial members, (d) determining a centroid of each of the plurality of fiducial members and a trajectory for a PCI according to the CT image, (e) configuring a parallel robot by a computer processor according to the CT image such that a top platform of the parallel robot is aligned with the trajectory with respect to the centroids of the plurality of fiducial members, (f) attaching the configured parallel robot to the docking frame, and (g) performing the PCI using one or more surgical tools received by the top platform of the parallel robot. | 12-29-2011 |
20110295353 | PATENT BODY LUMEN STENT - A stent implantable in a patent body lumen. The stent comprises a contiguous wire body having a plurality of sequential reversal coils that, when deployed in the patent lumen, are each configured to conform to the shape of the patent lumen and collectively have sufficient radial strength to prevent substantial narrowing of the patent lumen. | 12-01-2011 |
20110295271 | APPARATUS FOR SUPPORTING AN ADJUSTABLE SURGICAL PLATFORM - In one aspect, an apparatus for supporting an adjustable surgical platform is disclosed. In one embodiment, the apparatus includes a supporting platform portion with a body portion that defines bore along a central axis. Arm portions with engaging means extend radially from the supporting platform portion. The apparatus also includes a shaft portion extending from the supporting platform portion in a first direction, with a shaft body portion that defines a bore along a longitudinal axis B. The bore of the shaft body portion is in communication with the bore of the supporting platform portion. The apparatus further includes a base portion connected to the shaft portion, and that defines a bore in communication with the bore of the shaft portion and the bore of the supporting platform portion. Mounting means are configured to secure the base portion to a region of interest of a living subject. | 12-01-2011 |
20110295125 | Apparatus and method for radio frequency ablation of a liver tumor in liver tissues - A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a coherent light, collecting fluorescent light returned from the illuminated cell or tissue of the living subject, identifying a NAD(P)H peak of a spectrum of the collected fluorescent light with a wavelength, λ | 12-01-2011 |
20110294202 | BIOREACTORS WITH MULTIPLE CHAMBERS - A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further has a barrier dividing the chamber into a first subchamber and a second subchamber, wherein the barrier has a porosity to allow the first subchamber and the second subchamber in fluid communication and allow at least one predetermined type of cells to permeate between the first subchamber and the second subchamber. | 12-01-2011 |
20110270148 | PERCUTANEOUS COLLATERAL BYPASS - A bypass provided by a bypass conduit disposed in a vessel which is collateral to an occluded vessel. The bypass conduit comprises a helical wire body having a plurality of connectors connecting adjacent turns of the helical body. | 11-03-2011 |
20110246403 | Method and System for Automated Supervised Data Analysis - The invention relates to a method for automatically analyzing data and constructing data classification models based on the data. In an embodiment of the method, the method includes selecting a best combination of methods from a plurality of classification, predictor selection, and data preparatory methods; and determining a best model that corresponds to one or more best parameters of the classification, predictor selection, and data preparatory methods for the data to be analyzed. The method also includes estimating the performance of the best model using new data that was not used in selecting the best combination of methods or in determining the best model; and returning a small set of predictors sufficient for the classification task. | 10-06-2011 |
20110243992 | METHODS OF ENHANCING THE IMMUNOGENICITY OF MYCOBACTERIA AND COMPOSITIONS FOR THE TREATMENT OF CANCER, TUBERCULOSIS, AND FIBROSING LUNG DISEASES - Whole-cell vaccines and methods for enhancing the immunogenicity of cellular microorganisms for use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria or for use as vectors to express exogenous antigens and induce responses against other infectious agents or cancer cells. The present invention involves an additional method of enhancing antigen presentation by intracellular bacteria in a manner that improves vaccine efficacy. After identifying an enzyme that has an anti-apoptotic effect upon host cells infected by an intracellular microbe, the activity of the enzyme produced by the intracellular microbe is reduced by expressing a mutant copy of the enzyme, thereby modifying the microbe so that it increases immunogenicity. | 10-06-2011 |
20110237602 | METHOD FOR TREATING SCHIZOPHRENIA AND RELATED DISEASES - The invention relates to a method for treating schizophrenia and/or related diseases comprising administering lurasidone and a mGluR2 ligand to a mammal in need thereof. | 09-29-2011 |
20110230895 | ADJUSTABLE SURGICAL PLATFORM AND SURGICAL INSTRUMENT USING SAME - In one aspect, the present invention relates to a surgical instrument for providing an access to a target of interest of a living subject. In one embodiment, the surgical instrument has a bearing member, a shaft member and a probe. The bearing member has a first end portion, an opposite, second end portion, a body portion defined therebetween having a longitudinal axis, and a shoulder portion extending from the second end portion. The body portion defines a bore therein along the longitudinal axis. The shoulder portion defines a passage substantially coaxial with and in communication with the bore. The shaft member has an first end portion and an opposite, second end portion, and is slidably received in the bore of the bearing member. The shaft member defines a space extending from the first end portion to the second end portion. The probe has a working end portion and is received in the space of the shaft member such that the working end portion is extendable through the passage of the shoulder portion of the bearing member to reach a target of interest of a living subject so as to provide an access thereto. | 09-22-2011 |
20110229525 | MODULATION OF CYTOKINE SIGNALING - Cell penetrating suppressor of cytokine signaling (CP-SOCS) molecules engineered to be resistant to intracellular degradation are discussed. Methods of treating diseases associated with cytokine signaling include one or more CP-SOCS degradation resistant molecules. | 09-22-2011 |
20110224803 | POWERED LEG PROSTHESIS AND CONTROL METHODOLOGIES FOR OBTAINING NEAR NORMAL GAIT - A powered leg prosthesis includes powered knee joint comprising a knee joint and a knee motor unit for delivering power to the knee joint. The prosthesis also includes a prosthetic lower leg having a socket interface coupled to the knee joint and a powered ankle joint coupled to the lower leg opposite the knee joint comprising an ankle, joint and an ankle motor unit to deliver power to the ankle joint. The prosthesis further includes a prosthetic foot coupled to the ankle joint, at least one sensor for measuring a real-time input, and at least one controller for controlling movement of the prosthesis based on the real-time input. | 09-15-2011 |
20110221749 | Photolithographed Micro-Mirror Well For 3D Tomogram Imaging of Individual Cells - A micro-mirror well. In one embodiment the micro-mirror well includes a plurality of planar mirrors arranged around an axis of symmetry and inclined to form a pyramid well, where each of the plurality of planar mirrors is capable of reflecting light emitting from an object of interest placed inside the pyramid well. | 09-15-2011 |
20110217316 | GBS Toxin Receptor Compositions and Methods of Use - Methods are provided for preventing or attenuating pathoangiogenic conditions by administering at least one GBS toxin receptor polypeptide or at least one immunogenic fragment thereof. Also provided are a composition that includes a GBS toxin receptor polypeptide and a method for making such a composition. In another embodiment of the invention, immunized animals also receive GBS toxin, immunocompatible antibodies to the GBS toxin receptor, and/or expanded autologous T cells to the GBS toxin receptor. Also included in this invention are methods of identifying additional GBS toxin receptors. | 09-08-2011 |
20110213293 | LIGANDS TO RADIATION-INDUCED MOLECULES - A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands. | 09-01-2011 |
20110202324 | SYSTEM AND METHODS FOR ACCELERATING SIMULATION OF RADIATION TREATMENT - A method for estimating a radiation dose and distribution for a target volume is provided. The method includes receiving a simulated dose array ( | 08-18-2011 |
20110201032 | Immunosensors: scFv-linker design for surface immobilization - An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule specific for the analyte of interest, having one or more amino acids with charged or hydrogen-bond forming sidechains in a linker polypeptide portion, is bound to the layer on the solid substrate. When the analyte of interest is present in the sample the scFv binds the analyte to the solid substrate. The apparatus can be used with an immunoglobulin layer to detect Fc receptors, so as to detect microorganisms such as | 08-18-2011 |
20110194066 | ILLUMINATED LOW-VISION SPECTACLES - Lighted reading glasses for individuals with low vision. In one embodiment, the reading glasses include a frame for supporting lenses having an oculus dexter side and an oculus sinister side, at least one oculus dexter lens supported by the frame on the oculus dexter side, and at least one oculus sinister lens supported by the frame on the oculus sinister side, each of the at least one oculus dexter lens and the at least one sinister lens having an induced prism in a range between about 4 PD and about 22 PD and a lens power that is greater than about +4.00 diopters and less than about +20.00 diopters such that each of said lenses focuses at a distance that is greater than about 5 cm and less than about 25 cm, and at least one light source having a predetermined light strength oriented to project light to provide a predetermined lighted area in a predetermined field. | 08-11-2011 |
20110189193 | CELL LINES AND HOST NUCLEIC ACID SEQUENCES RELATED TO INFECTIOUS DISEASE - Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or resistance to infection. Thus, interfering with such an interaction in a host subject can confer a therapeutic or prophylactic effect against a virus. The sequences identified can be used to identify agents that reduce or inhibit viral infection. | 08-04-2011 |
20110184306 | DEVICE FOR TREATING PARKINSON'S DISEASE AND METHODS OF USE THEREOF - The invention includes a recordation and stimulation system for determining and delivering an electrical stimulation treatment based upon the current status of neuronal activity of a subject. The system include components for detecting neuronal activity in a subject's brain and, based upon the information received, determine an appropriate electrical stimulation treatment for the subject. The system allows immediate adjustments to the stimulation treatment as the needs of the subject change over time. The invention also includes a method for determining whether a subject has early Parkinson's Disease or advanced Parkinson's Disease. The method includes the steps of acquiring information regarding neuronal discharges in certain areas of the brain, creating a ratio based upon the neuronal activity, and determining whether a previous medical diagnosis of Parkinson's Disease is accurate. | 07-28-2011 |
20110178394 | SYSTEM AND METHOD FOR POINT-BASED RIGID REGISTRATION WITH ANISOTROPIC WEIGHTING - Systems and methods for performing computer-assisted procedures are provided. In the systems and methods, a current rigid transformation is applied to a first set of points with respect to a second set of poi s to obtain a current transformed set of points. Thereafter, a linearized transformation is determined that minimizes a weighted fiducial registration error between the current transformed set and the second set. An updated rigid transformation is then obtained based on the current rigid transformation, the translation vector of the linearized transformation, and a rotation matrix that is closest to the linearized matrix of the linearized transformation, followed by applying the updated rigid transformation to the first set to obtain an updated transformed set of points. Finally, if motion associated with such updating fails to meet some criterion, the determining, obtaining, and applying are iteratively repeated using the updated rigid transformation and the updated transformed set. | 07-21-2011 |
20110172725 | NERVE STIMULATOR AND METHOD USING SIMULTANEOUS ELECTRICAL AND OPTICAL SIGNALS - An apparatus and method for stimulating animal tissue (for example to trigger a nerve action potential (NAP) signal in a human patient) by application of both electrical and optical signals for treatment and diagnosis purposes. The application of an electrical signal before or simultaneously to the application of a NAP-triggering optical signal allows the use of a lower amount of optical power or energy than would otherwise be needed if an optical signal alone was used for the same purpose and effectiveness. The application of the electrical signal may precondition the nerve tissue such that a lower-power optical signal can be used to trigger the desired NAP, which otherwise would take a higher-power optical signal were the electric signal not applied. Some embodiments include an implanted nerve interface having a plurality of closely spaced electrodes placed transversely and/or longitudinally to the nerve and a plurality of optical emitters. | 07-14-2011 |
20110172552 | ACOUSTIC SLEEP APNEA MONITOR - The present invention discloses an apparatus and method for monitoring an individual for an irregular respiratory event. The present invention discloses a sleep apnea monitor for monitoring an individual for an apneic event. The monitor includes a microphone for detecting tracheal sounds related to respiration so that irregular lengths of time between such sounds may activate an alert of the medical condition. The method of monitoring an individual for an irregular respiratory event includes attaching the monitor in a nonintrusive manner to a location around the throat area. | 07-14-2011 |
20110160800 | SYSTEM AND METHODS OF DEEP BRAIN STIMULATION FOR POST-OPERATION PATIENTS - A method for programming a deep brain stimulator implanted in a target region of a brain of a living subject for optimal stimulation, wherein the deep brain stimulator comprises at least one electrode having a plurality of electrode contacts spaced apart from each other, and any portion of the brain of the living subject is identifiable by a set of corresponding spatial coordinates. In one embodiment, the method comprises the steps of creating an efficacy atlas in which any spatial coordinates for a position in a target region of the brain of the living subject are related to a position with corresponding atlas coordinates in the efficacy atlas, and each position in the atlas coordinates of the efficacy atlas is associated with an efficacy of stimulation at a corresponding position in the spatial coordinates of the brain of the living subject; acquiring a position of each electrode contact of the at least one electrode in the spatial coordinates of the brain of the living subject; mapping the acquired position of each electrode contact of the at least one electrode in the spatial coordinates of the brain of the living subject onto a corresponding position in the efficacy atlas so as to determine the efficacy of stimulation at the acquired position in the spatial coordinates of the brain of the living subject; and selecting one or more electrode contacts having the highest efficacy for stimulation. | 06-30-2011 |
20110118597 | SYSTEM AND METHOD FOR SURGICAL INSTRUMENT DISABLEMENT VIA IMAGE-GUIDED POSITION FEEDBACK - A system for selectively disabling a surgical instrument operating in a surgical site of a region of interest of a living subject. In one embodiment, the system includes means for noninvasively placing a number of fiducial markers in an anatomic space of the region of interest of the living subject, means for pre-operatively measuring a location of each fiducial marker in the anatomic space, an imaging acquisition device for pre-operatively acquiring an image volume from the region of interest of the living subject, a probe for intra-operatively monitoring a location of the surgical instrument in the anatomic space, and a controller configured to perform the steps of identifying a centroid of each fiducial marker in the image volume, registering the identified centroid of each fiducial marker in the image volume to the measured location of the corresponding fiducial marker in the anatomic space to determine a registration transformation, mapping the monitored location of the surgical instrument in the anatomic space onto a corresponding location in the image volume by an inverse of the registration transformation, and generating a signal to disable the surgical instrument when the mapped location of the surgical instrument is substantially close to a boundary of the surgical site of the region of interest in the image volume. | 05-19-2011 |
20110117008 | USE OF AVICINS TO DELIVER THERAPEUTIC AND DIAGNOSTIC AGENTS - The present invention provides compositions of avicins and avicin mixtures that enhance topical, percutaneous, transmucosal, transepithelial, transendothelial or transdermal transport of agents including diagnostic molecules, therapeutic drugs and cosmetic materials. | 05-19-2011 |
20110098569 | Method and Apparatus for Standardizing Ultrasonography Training Using Image to Physical Space Registration of Tomographic Volumes from Tracked Ultrasound - A clinical and training apparatus that collects and processes physical space data while performing an image-guided procedure on an anatomical area of interest includes a calibration probe, a tracked ultrasonic probe, a wireless tracking device that tracks the ultrasonic probe in space and an image data processor. The physical space data provides three-dimensional coordinates for each of the physical points. The image data processor includes a memory holding instructions. The instructions include determining registrations used to indicate position in image space and physical space; using the registrations to map into image space, image data describing the physical space of the tracked ultrasonic probe and the anatomical area of interest; and constructing a three-dimensional (3D) volume based on ultrasonic image data. The apparatus includes a storage medium that stores a plurality of 3D volumes acquired by the image data processor for later retrieval. | 04-28-2011 |
20110097423 | Gene Prognosis Predictor Signature for Colorectal Carcinoma - The present invention is drawn to methods of assessing colorectal cancer prognosis by examining the expression of particular genes disregulated in this disease state. Subjects exhibiting disregulation in one or more of these genes will have a higher risk of cancer recurrence and death. | 04-28-2011 |