University of Washington Patent applications |
Patent application number | Title | Published |
20160138086 | METHODS AND KITS FOR LABELING CELLULAR MOLECULES - Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. | 05-19-2016 |
20160137703 | MSP Nanopores and Related Methods - Provided herein are | 05-19-2016 |
20160136189 | METHODS FOR TREATING AND PREVENTING PROSTATE CANCER BONE METASTASES - Methods for treating a subject having a prostate cancer bone metastasis are disclosed. Methods for prophylactically treating a subject at risk of developing a prostate cancer bone metastasis are also disclosed. The methods for treating a subject having, or at risk of developing, a prostate cancer bone metastasis may include administering a prostatic acid phosphatase inhibiting agent to the subject. The methods for treating a subject having, or at risk of developing, a prostate cancer bone metastasis may also include administering a phosphonic acid to the subject. Further, the phosphonic acid may include a benzylaminophosphonic acid, such as [phenyl[(phenylmethyl)amino]methyl]-phosphonic acid). | 05-19-2016 |
20160130555 | METHODS FOR MATURING CARDIOMYOCYTES AND USES THEREOF - Described herein are methods and compositions useful for inducing maturation of a cardiomyocyte to a mature (e.g., adult) phenotype, such that the function and morphology of the mature cardiomyocyte matches or more closely mimics that of the adult heart. The methods and compositions use Let-7 miRNAs and modified forms thereof. Such methods and compositions permit the study and treatment of adult-onset cardiac diseases, disorders or injuries with mature cardiomyocytes that mimic the heart function of an adult. Methods of using cardiomyocytes matured in this manner for drug identification and drug cardiotoxicity testing are also provided. | 05-12-2016 |
20160106800 | METHODS FOR THE PREVENTION OR TREATMENT OF HEART FAILURE - The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. | 04-21-2016 |
20160095918 | RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME - A method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 04-07-2016 |
20160066553 | CONTROLLED RELEASE OF CARBON DIOXIDE FROM SELF-IMMOLATIVE POLYMERS - The present disclosure is directed to a carbon dioxide-releasing device, including a chamber having a sealable aperture for receiving a first material; a carbon dioxide-releasing polymer disposed within the chamber; and a port for releasing a carbon dioxide generated by the carbon dioxide-releasing polymer from the chamber. The carbon-dioxide releasing polymer can be a self-immolative polymer. | 03-10-2016 |
20160050343 | USING DYNAMIC MODE DECOMPOSITION FOR REAL-TIME BACKGROUND/FOREGROUND SEPARATION IN VIDEO - The technique of dynamic mode decomposition (DMD) is disclosed herein for the purpose of robustly separating video frames into background (low-rank) and foreground (sparse) components in real-time. Foreground/background separation is achieved at the computational cost of just one singular value decomposition (SVD) and one linear equation solve, thus producing results orders of magnitude faster than robust principal component analysis (RPCA). Additional techniques, including techniques for analyzing the video for multi-resolution time-scale components, and techniques for reusing computations to allow processing of streaming video in real time, are also described herein. | 02-18-2016 |
20160043526 | TUNING MULTI-INPUT COMPLEX DYNAMIC SYSTEMS USING SPARSE REPRESENTATIONS OF PERFORMANCE AND EXTREMUM-SEEKING CONTROL - Systems and methods for tuning multi-input complex dynamic systems in order to automatically obtain optimal performance are provided. Training is performed by measuring performance of the complex system using an objective function for a sparse sampling of input values over a variety of dynamic regimes. A sparse representation of the performance for each dynamic regime is stored in a library. At run-time, performance is measured and matched to a sparse representation in the library, and the complex system is configured with the optimal input values associated with the matching sparse representation from the library. Performance may then be optimized using an extremum-seeking controller. In some embodiments, the disclosed techniques are applied to a self-tuning mode-locked laser. In some embodiments, the disclosed techniques are applied to other complex systems such as phased array antennas and neurostimulation systems. | 02-11-2016 |
20160025677 | PARTICLE CONCENTRATION SYSTEM - Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface. | 01-28-2016 |
20150353985 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY - Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I. | 12-10-2015 |
20150336174 | METHODS FOR PRODUCTION OF SILVER NANOSTRUCTURES - Methods for producing silver nanostructures with improved dimensional control, yield, purity, monodispersity, and scale of synthesis. | 11-26-2015 |
20150335734 | ANTIGENIC PEPTIDE OF HSV-2 AND METHODS FOR USING SAME - The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection, including epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 11-26-2015 |
20150322189 | MIXED CHARGE COPOLYMERS AND HYDROGELS - Nonfouling copolymers and hydrogels comprising positively charged repeating units or latent positively charged repeating units and negatively charged units or latent positively charged units. | 11-12-2015 |
20150322134 | INDUCIBLE MUTAGENESIS OF TARGET GENES - The present invention relates generally to mutagenesis of target genes that takes advantage of the natural mutagenic capabilities of B cells, and enhances those capabilities by bringing the process of diversification under control. The invention provides a method for rapidly and inducibly generating point mutations and other types of diversification in expressed genes, such as antibody genes. This method can be coupled with selection to identify B cell clones that produce, for example, antibodies of high affinity or specificity. The diversification process can be modulated, accelerated, halted, switched between methods of mutagenesis and the like. The modulation of diversification in accordance with the invention is both inducible and reversible. The invention provides a means of rapid and feasible development of a repertoire of variant immunoglobulins and other polypeptides. | 11-12-2015 |
20150320890 | NANOPARTICLES FOR BRAIN TUMOR IMAGING - Nanoparticle having a chitosan-polyethylene oxide oligomer copolymer coating, and methods for making and using the nanoparticle are provided. The nanoparticle can have a core that includes a material that imparts magnetic resonance imaging activity to the particle and, optionally, one or more of an associated targeting agent, fluorescent agent, or therapeutic agent. | 11-12-2015 |
20150282811 | NANOFIBROUS CONDUITS FOR NERVE REGENERATION - A hollow fibrous conduit for promoting regeneration of a severed nerve, comprising a first end for coapting the conduit to a first end of a severed nerve and second end for coapting the conduit to a second end of the severed nerve, the hollow fibrous conduit comprising chitosan-poly(caprolactone) fibers. Methods for making the conduit and methods for using the conduit for nerve regeneration. | 10-08-2015 |
20150281630 | SCANNING LASER PROJECTION DISPLAY DEVICES AND METHODS FOR PROJECTING ONE OR MORE IMAGES ONTO A SURFACE WITH LIGHT-SCANNING OPTICAL FIBER - Image projection devices, high-speed fiber scanned displays and related methods for projecting an image onto a surface and interfacing with the projected image are provided. A method for projecting one or more images and obtaining feedback with an optical input-output assembly is provided. The input-output assembly comprising a light-scanning optical fiber and a sensor. The method includes generating a sequence of light in response to one or more image representations and a scan pattern of the optical fiber, articulating the optical fiber in the scan pattern, projecting the sequence of light from the articulated optical fiber, and generating a feedback signal with the sensor in response to reflections of the sequence of light. | 10-01-2015 |
20150267311 | BIPOLAR ELECTROCHEMICAL PRINTING - A bipolar electrochemistry printer and method are disclosed wherein electrolytic deposition onto a conductive substrate is accomplished by inducing ionic current in an electrolytic cell disposed above the substrate to undergo charge transfer at the conductive substrate, such that a portion of the substrate becomes a bipolar electrode. The ohmic current in the substrate undergoes a second charge transfer back to ionic current and returning to the cathode of the electrolytic cell. In an alternative embodiment the printing is similarly accomplished by electrolytic etching. | 09-24-2015 |
20150238619 | POLYMERIC CARRIER - Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g., oligonucleotides) and/or other therapeutic agents into a living cell. | 08-27-2015 |
20150158900 | METHOD FOR 2-SULFATION OF GLYCOSIDES - Method for selective 2-sulfation of glycosides. | 06-11-2015 |
20150141860 | LONG-TERM MONITORING FOR DISCRIMINATION OF DIFFERENT HEART RHYTHMS - A method, system, and device for detection of an arrhythmia, and discrimination between different types of arrhythmia, for example to determine whether to administer an electric shock to the heart, the device comprising a wearable monitor with electrodes that detect the electrical activity of a beating heart, attached to an embedded monitoring system having an amplifier, a microprocessor, a data storage device, and a power supply, all disposed on a substrate having large distal end portions that attach to the electrodes and a narrow intermediate portion that attaches to the monitoring system. | 05-21-2015 |
20150133344 | SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG SEQUENCING READS - The invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences for genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes. | 05-14-2015 |
20150099463 | METHOD AND APPARATUS FOR USING IN-HOME POWER LINES TO SUPPORT LOW POWER WIRELESS SENSORS AND TO EXTEND THE RANGE OF LOW-POWER WIRELESS DEVICES - Disclosed is a system that uses existing power line infrastructure in a building as a distributed reception antenna capable of receiving signals from very low-power wireless sensors, thus allowing these sensors to be detected at ranges that are otherwise impractical with over-the-air reception. Also disclosed is a wireless sensor platform that is able to be sensed throughout a building with very low current draw. The disclosed technique may also be utilized to extend the range of mid-frequency consumer electronic devices by leveraging the power line as a reception antenna. | 04-09-2015 |
20150037870 | ENZYME CATALYSTS FOR DIELS-ALDER REACTIONS - The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other aspects, the invention provides methods of making the enzyme catalysts, including by de novo computational design. The present invention thereby provides enzyme catalysts capable of catalyzing a desired Diels-Alder reaction, including with a specified or desired stereo-selectivity. | 02-05-2015 |
20140370567 | DUAL-FUNCTIONAL NONFOULING SURFACES COMPRISING TARGET BINDING PARTNER COVALENTLY COUPLED TO POLYMER ATTACHED TO SUBSTRATE - Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery. | 12-18-2014 |
20140347669 | Dynamic Characterization of Particles With Flow Cytometry - Flow cytometry concepts are modified to enable dynamic characterizations of particles to be obtained using optical scattering data. Particles in flow will be introduced into a sample volume. Light scattered by a particle in the sample volume is collected and analyzed. What differentiates the concepts disclosed herein from conventional flow cytometry is the use of an acoustic source that is disposed to direct acoustic energy into the sample volume. As the particle passes through the sample volume, it responds to the acoustic energy, causing changes in the light scattered by the particle. Those changes, which are not measured during conventional flow cytometry, can be analyzed to determine additional physical properties of the particle. | 11-27-2014 |
20140328525 | IMAGE BASED CLINICAL TRIAL ASSESSMENT - A method for assessing a treatment in a trial includes obtaining images generated from image data acquired at different times during a trial time period for a same region of interest of a subject. The treatment is administered to the subject for the trial. The method further includes co-registering the images and mapping the co-registered images to a reference image representing the region of interest. The method further includes generating a trial image of the region of interest showing at least one of structural or functional physiological changes that occurred during the trial time period based on the mapped co-registered images, and displaying the trial image. | 11-06-2014 |
20140322269 | ENGINEERED OUTER DOMAIN (EOD) OF HIV GP120 AND MUTANTS THEREOF - The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings. | 10-30-2014 |
20140309402 | MSP NANOPORES AND RELATED METHODS - Provided herein are | 10-16-2014 |
20140308662 | MSP NANOPORES AND RELATED METHODS - Provided herein are | 10-16-2014 |
20140256913 | MSP NANOPORES AND RELATED METHODS - Provided herein are | 09-11-2014 |
20140251808 | METHOD AND SYSTEM FOR CONCENTRATING PARTICLES FROM A SOLUTION - Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface. | 09-11-2014 |
20140241993 | FLUORESCENT CHLOROTOXIN CONJUGATE AND METHOD FOR INTRA-OPERATIVE VISUALIZATION OF CANCER - A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate. | 08-28-2014 |
20140235803 | PARTICLES COATED WITH ZWITTERIONIC POLYMERS - Nanoparticles zwitterionic polymers grafted thereto or grafted therefrom, and methods for making and using the nanoparticles. Zwitterionic nanogels, and methods for making and using the nanogels. | 08-21-2014 |
20140220673 | METHODS AND APPARATUS FOR THE ISOLATION AND ENRICHMENT OF CIRCULATING TUMOR CELLS - Embodiments in accordance with the present invention relate to methods and apparatuses for concentrating and isolating Circulating Tumor Cells (CTCs) from body fluids. One embodiment of the present invention includes a micro-fabricated or nano-fabricated device having channels configured for separating and excluding. Embodiments in accordance with the present invention utilize features that reduce the hydrodynamic pressure experienced by the cells during the separation, isolation and concentration processes, and therefore reduce the likelihood of cell lysis or other damage to the cells. | 08-07-2014 |
20140220014 | LEVELS OF BCMA PROTEIN EXPRESSION ON B CELLS AND USE IN DIAGNOSTIC METHODS - The present invention provides a method of measuring the levels of BCMA in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with BLyS antagonists, either singly or in combination with other immune suppressive drugs | 08-07-2014 |
20140219950 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents. | 08-07-2014 |
20140178381 | RETROGRADE TRANSPORT PEPTIDE AND USE OF SAME FOR DELIVERY TO CENTRAL NERVOUS SYSTEM - Transport peptides, alone or attached to a cargo moiety, are capable of targeted axonal import into the spinal cord and other structures of the central nervous system. The transport peptides can be used to deliver therapeutic agents and other molecules of interest from the periphery to the central nervous system, providing a means to detect, treat or prevent neurodegenerative diseases, stroke, chronic pain and other conditions via minimally invasive techniques of administration. | 06-26-2014 |
20140178379 | Therapeutic Nuclease Compositions and Methods - Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal. | 06-26-2014 |
20140148900 | DEVICE AND METHOD FOR INTRAOCULAR DRUG DELIVERY - Intraocular devices having a drug delivery construct attached thereto, and methods for using the devices for intraocular drug delivery and the treatment and/or prevention of conditions. | 05-29-2014 |
20140148505 | METHODS AND COMPOSITIONS FOR PREDICTING DRUG RESPONSES - The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene. | 05-29-2014 |
20140128345 | VAGINAL MATRICES: NANOFIBERS FOR CONTRACEPTION AND PREVENTION OF HIV INFECTION - Described are drug delivery systems incorporating electrospun fibers that comprise and deliver physicochemically diverse drug compounds. Such fibers provide significant advantages in drug agent release, such as adaptability for solid dosage delivery to mucosal tissues. This is in addition to allowing for controlled drug release. Systems and methods for large-scale electrospinning productivity are described, including novel microarchitectures allowing for variable pharmacokinetics in drug release. | 05-08-2014 |
20140100166 | METHODS FOR THE PREVENTION OR TREATMENT OF HEART FAILURE - The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. | 04-10-2014 |
20140087460 | INDUCTION OF HUMAN EMBRYONIC STEM CELL DERIVED CARDIAC PACEMAKER OR CHAMBER-TYPE CARDIOMYOCYTES BY MANIPULATION OF NEUREGULIN SIGNALING - The present invention is directed to methods of producing cardiomyocytes having a nodal/pacemaker phenotype and cardiomyocytes having an atrial/ventricular phenotype. Isolated populations of nodal/pacemaker and atrial/ventricular cardiomyocytes are also disclosed. Methods of treating a subject having cardiac arrhythmia and a subject in need of cardiac tissue repair using the isolated populations of nodal/pacemaker cardiomyocytes and atrial/ventricular cardiomyocytes, receptively, are also disclosed. | 03-27-2014 |
20140080775 | MOLECULAR MODULATORS OF THE WNT/BETA-CATENIN PATHWAY - The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject at least one compound selected from the group consisting of those set forth in Table 1, Table 2, Table 3, and a pharmaceutically acceptable salt thereof. A method of similarly modulating the Wnt/β-catenin pathway in a subject is also discussed. | 03-20-2014 |
20140051729 | COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE MUSCLE CONDITIONS - Methods and compositions for treating degenerative muscle conditions are disclosed. The compositions disclosed herein include S1P promoting compositions that include an S1P promoting agent. Embodiments of the methods disclosed herein include administering therapeutically effective amounts to subjects suffering from a degenerative muscle condition, such as, for example, subjects suffering from sarcopenia and subjects suffering from muscular dystrophy, including subjects suffering from Duchenne Muscular Dystrophy and Becker Muscular Dystrophy. | 02-20-2014 |
20140044711 | Therapeutic Nuclease Compositions and Methods - Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal. | 02-13-2014 |
20140042326 | METHOD FOR DETERMINING THE THREE-DIMENSIONAL POSITION OF A SCINTILLATION EVENT - A method is provided for determining the three-dimensional position of an interaction location within a scintillating crystal at which an high-energy photon produces a plurality of scintillation photons. The method includes the use of a sensor-on-entrance-surface photodetector device to determine a distribution pattern of the scintillation photons in the crystal. | 02-13-2014 |
20140039279 | ACOUSTIC PALPATION USING NON-INVASIVE ULTRASOUND TECHNIQUES FOR IDENTIFICATION OF TARGET SITES AND ASSESSMENT OF CHRONIC PAIN DISORDERS - Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions. | 02-06-2014 |
20140035581 | INTERLEAVED BLACK AND BRIGHT BLOOD DYNAMIC CONTRAST ENHANCED (DCE) MRI - Interleaved black/bright imaging (IBBI) is performed using a magnetic resonance (MR) scanner ( | 02-06-2014 |
20140026644 | Sensing Events Affecting Liquid Flow in a Liquid Distribution System - By monitoring pressure transients in a liquid within a liquid distribution system using only a single sensor, events such as the opening and closing of valves at specific fixtures are readily detected. The sensor, which can readily be coupled to a faucet bib, transmits an output signal to a computing device. Each such event can be identified by the device based by comparing characteristic features of the pressure transient waveform with previously observed characteristic features for events in the system. These characteristic features, which can include the varying pressure, derivative, and real Cepstrum of the pressure transient waveform, can be used to select a specific fixture where a valve open or close event has occurred. Flow to each fixture and leaks in the system can also be determined from the pressure transient signal. A second sensor disposed at a point disparate from the first sensor provides further event information. | 01-30-2014 |
20130321982 | ELECTRODES AND ELECTRIC DOUBLE LAYER CAPACITANCE DEVICES COMPRISING AN ACTIVATED CARBON CRYOGEL - The present application is directed to electric double layer capacitance (EDLC) devices. In one aspect, the present application is directed to an electrode comprising an activated carbon cryogel having a tunable pore structure wherein: the surface area is at least 1500 m2/g as determined by nitrogen sorption at 77K and BET analysis; and the pore structure comprises a pore volume ranging from about 0.01 cc/g to about 0.25 cc/g for pores having a pore diameter of 0.6 to 1.0 nm. In another aspect, the present application is directed to an Electric Double Layer Capacitor (EDLC) device comprising an activated cryogel. | 12-05-2013 |
20130309262 | HSV-1 EPITOPES AND METHODS FOR USING SAME - The invention provides HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 11-21-2013 |
20130302364 | HIGHLY IMMUNOGENIC HIV P24 SEQUENCES - The invention relates to peptides comprising part or all of a conserved element within a Center-of-Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides. | 11-14-2013 |
20130254666 | Navigating Images Using Image Based Geometric Alignment And Object Based Controls - Over the past few years there has been a dramatic proliferation of digital cameras, and it has become increasingly easy to share large numbers of photographs with many other people. These trends have contributed to the availability of large databases of photographs. Effectively organizing, browsing, and visualizing such .scas. of images, as well as finding a particular image, can be difficult tasks. In this paper, we demonstrate that knowledge of where images were taken and where they were pointed makes it possible to visualize large sets of photographs in powerful, intuitive new ways. We present and evaluate a set of novel tools that use location and orientation information, derived semi-automatically using structure from motion, to enhance the experience of exploring such large collections of images. | 09-26-2013 |
20130251073 | Simplified High Frequency Tuner and Tuning Method - A disclosed method tunes a signal from a channelized spectrum having a predetermined channel spacing. A signal of interest having a predetermined maximum bandwidth is mixed with a local oscillator signal, which has a frequency that is an integer multiple of the channel spacing or one-half of a channel spacing displaced from an integer multiple of the channel spacing. The local oscillator signal is selected to frequency translate the signal of interest to within a near-baseband passband whose lower edge is spaced from DC by at least about the maximum bandwidth of the signal of interest. Problems associated with 1/f noise, DC offsets, and self-mixing products are avoided or substantially diminished. Other methods and systems are also disclosed. | 09-26-2013 |
20130246497 | ADAPTIVE PRECISION ARITHMETIC UNIT FOR ERROR TOLERANT APPLICATIONS - Two process-tolerant arithmetic circuit architectures are implemented to develop functional blocks for error-tolerant applications such as FIR filters and FFT blocks. The resulting blocks may achieve computational performance of up to 42 times higher than conventional architectures. Embodiments adaptively change the precision of the computation to achieve a high precision computation given the underlying speed of the circuit. The resulting improvement can be allocated to increasing yield or dynamically trading off between reduced power consumption, faster computation, or higher-fidelity computation. | 09-19-2013 |
20130240364 | COMPOSITE PHOTOANODES - The provided method includes photoelectrodeposition of an electrocatalyst onto a semiconductor to form a photoanode. The method yields composite photoanodes showing enhancement of photocurrent (water splitting rate) when incorporated into a photoelectrochemical cell for water electrolysis. | 09-19-2013 |
20130224236 | HSV-1 EPITOPES AND METHODS FOR USING SAME - The invention provides HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 08-29-2013 |
20130209430 | METHODS FOR REGULATION OF STEM CELLS - Methods are provided for increasing stem cells, hematopoietic progenitor/stem cells, mesenchymal progenitor/stem cells, mesodermal progenitor/stem cells, muscle progenitor/stem cells, or neural progenitor/stem cells in vivo in a mammalian subject. Methods are also provided for treating an immune related disease, a mesenchymal/mesoderm degenerative disease, or a neurodegenerative disease in a mammalian subject in need thereof. | 08-15-2013 |
20130207780 | SCALABLE RFID SYSTEMS: A PRIVACY-PRESERVING PROTOCOL WITH CONSTANT-TIME IDENTIFICATION - A protocol with constant-time complexity solves the problem of private identification of tags in low-cost, large-scale radio frequency identification (RFID) systems—assuming that an adversary has complete control over the communication channel. Each RFID tag has an internal counter, c, and is preloaded with a unique pseudonym, ψ, and a secret key, k. A RFID reader attempting to identify and authenticate a tag within its range generates and transmits a random nonce to the RFID tag, which returns a first hash of its current pseudonym and counter, and a second hash that is a function of the secret key. The reader uses the returned data to identify the RFID tag and its secret key by reference to a database and returns other hash values that authenticate the reader to the RFID tag. The most expensive operation that RFID tags are required to perform is a hash function. | 08-15-2013 |
20130196950 | RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF - Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided. | 08-01-2013 |
20130189294 | RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME - Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 07-25-2013 |
20130178125 | MARINE COATINGS - Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings. | 07-11-2013 |
20130158578 | NEUROSURGICAL DEVICES AND ASSOCIATED SYSTEMS AND METHODS - Neurosurgical devices including or used with cannulas or catheters and associated systems and methods are disclosed herein. The neurosurgical devices can include, for example, a cannula having a main portion and an angle-forming member proximate a distal end of the main portion. The angle-forming member can be configured to transition from a substantially straight configuration while the cannula is advanced through tissue along a substantially straight first portion of a path to an angled configuration when the angle-forming member reaches an end of the substantially straight first portion of the path. The neurosurgical devices also can include, for example, a neurosurgical catheter including a surface disrupter, an elongated macerator, or a lateral opening. Neurosurgical catheterization portals also are disclosed. The neurosurgical catheterization portals can, for example, have an adjustable portal that is movable relative to a body to accommodate different entry angles of a catheterization path. | 06-20-2013 |
20130158346 | Catheterscope 3D Guidance and Interface System - Visual-assisted guidance of an ultra-thin flexible endoscope to a predetermined region of interest within a lung during a bronchoscopy procedure. The region may be an opacity-identified by non-invasive imaging methods, such as high-resolution computed tomography (HRCT) or as a malignant lung mass that was diagnosed in a previous examination. An embedded position sensor on the flexible endoscope indicates the position of the distal tip of the probe in a Cartesian coordinate system during the procedure. A visual display is continually updated, showing the present position and orientation of the marker in a 3-D graphical airway model generated from image reconstruction. The visual display also includes windows depicting a virtual fly-through perspective and real-time video images acquired at the head of the endoscope, which can be stored as data, with an audio or textual account. | 06-20-2013 |
20130146457 | ANALYTE SEQUENCING WITH NANOPORES - Provided herein are methods and systems pertaining to sequencing units of analytes using nanopores. In general, arresting constructs are used to modify an analyte such that the modified analyte pauses in the opening of a nanopore. During such a pause, an ion current level is obtained that corresponds to a unit of the analyte. After altering the modified analyte such that the modified analyte advances through the opening, another arresting construct again pauses the analyte, allowing for a second ion current level to be obtained that represents a second unit of the analyte. This process may be repeated until each unit of the analyte is sequenced. Systems for performing such methods are also disclosed. | 06-13-2013 |
20130146456 | ARTIFICIAL MYCOLIC ACID MEMBRANES - Provided herein are artificial membranes of mycolic acids. The membranes may be unsupported or tethered. These membranes are long lived and highly resistant to electroporation, demonstrating their general strength. The mycolic acid membranes are suitable for controlled studies of the mycobacterial outer membrane and can be used in other experiments, such as nanopore analyte translocation experiments. | 06-13-2013 |
20130144146 | LONG-TERM MONITORING FOR DISCRIMINATION OF DIFFERENT HEART RHYTHMS - A method, system, and device for detection of an arrhythmia, and discrimination between different types of arrhythmia, for example to determine whether to administer an electric shock to the heart, the device comprising a wearable monitor with electrodes that detect the electrical activity of a beating heart, attached to an embedded monitoring system having an amplifier, a microprocessor, a data storage device, and a power supply, all disposed on a substrate having large distal end portions that attach to the electrodes and a narrow intermediate portion that attaches to the monitoring system. | 06-06-2013 |
20130142868 | Circumferential Aerosol Device for Delivering Drugs to Olfactory Epithelium and Brain - Methods of delivering a pharmaceutical compounds directly to the olfactory epithelium of a mammal by providing a pharmaceutical aerosol suspension comprising an aerosol and the pharmaceutical compound; aerosolizing the suspension to generate a stream of droplets, the stream having a rotational component, and, delivering the droplets directly to the olfactory epithelium, wherein at least 15% of the droplets are delivered directly to the olfactory deposition. The pharmaceutical compound may be encapsulated within a liposome nanoparticle. | 06-06-2013 |
20130137605 | SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG SEQUENCING READS - The invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences for genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes. | 05-30-2013 |
20130137588 | SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG SEQUENCING READS - The invention provides compositions and methods for preparing DNA sequencing libraries. In particular, the method relates to preparing DNA sequencing libraries from kilobase scale nucleic acids. The invention also provides methods for assembling short read sequencing data into longer contiguous sequences. The method is useful for various applications in genomics, including genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes. | 05-30-2013 |
20130121992 | MOLECULES AND METHODS FOR TREATMENT OF DIABETES - Described are antibodies that specifically recognize and bind the epitope of glutamate decarboxylase (GAD65) that is bound by antibody b96.11, and anti-idiotypic antibodies that are capable of competing with GAD65 for binding with b96.11 and competitively inhibit such binding. These antibodies can be provided in the form of a pharmaceutical composition and can be used in methods for delaying the onset of Type 1 diabetes and for inhibiting insulitis and other diabetic symptoms. Also provided are methods for detecting a susceptibility to Type 1 diabetes in a subject and for detecting the presence of anti-idiotypic antibodies to GAD65. The method comprises contacting a specimen with an antibody of the invention. The method further comprises detecting binding of the molecule to the specimen. The absence (or relative absence) of binding is indicative of susceptibility to Type 1 diabetes and of the absence of anti-idiotypic antibodies. | 05-16-2013 |
20130096431 | METHOD FOR USING HIGH INTENSITY FOCUSED ULTRASOUND AND ASSOCIATED SYSTEMS AND DEVICES - A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface. | 04-18-2013 |
20130095778 | Simplified High Frequency Tuner and Tuning Method - A disclosed method tunes a signal from a channelized spectrum having a predetermined channel spacing. A signal of interest having a predetermined maximum bandwidth is mixed with a local oscillator signal, which has a frequency that is an integer multiple of the channel spacing or one-half of a channel spacing displaced from an integer multiple of the channel spacing. The local oscillator signal is selected to frequency translate the signal of interest to within a near-baseband passband whose lower edge is spaced from DC by at least about the maximum bandwidth of the signal of interest. Problems associated with 1/f noise, DC offsets, and self-mixing products are avoided or substantially diminished. Other methods and systems are also disclosed. | 04-18-2013 |
20130089546 | THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS - Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal. | 04-11-2013 |
20130084596 | METHODS OF IDENTIFYING LEAD COMPOUNDS THAT MODULATE TOXICITY OF NEUROTOXIC POLYPEPTIDES - Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided. | 04-04-2013 |
20130079403 | RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS - Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided. | 03-28-2013 |
20130072569 | RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF - Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided. | 03-21-2013 |
20130072568 | RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF - Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided. | 03-21-2013 |
20130072561 | METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION - A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxyiates of C | 03-21-2013 |
20130072560 | RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS - Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided. | 03-21-2013 |
20130072559 | RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS - Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided. | 03-21-2013 |
20130072558 | METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION - A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C | 03-21-2013 |
20130072557 | METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION - A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C | 03-21-2013 |
20130072556 | RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS - Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided. | 03-21-2013 |
20130072443 | STABILIZED MUTANT OPSIN PROTEINS - Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids. | 03-21-2013 |
20130058384 | Frequency Multiplying Transceiver - Described herein is a wireless transceiver and related method that enables ultra low power transmission and reception of wireless communications. In an example embodiment of the wireless transceiver, the wireless transceiver receives a first-reference signal having a first-reference frequency. The wireless transceiver then uses the first-reference signal to injection lock a local oscillator, which provides a set of oscillation signals each having an oscillation frequency that is equal to the first-reference frequency, and each having equally spaced phases. Then the wireless transceiver combines the set of oscillation signals into an output signal having an output frequency that is one of (i) a multiple of the first-reference frequency (in accordance with a transmitter implementation) or (ii) a difference of (a) a second-reference frequency of a second-reference signal and (b) a multiple of the first- reference frequency (in accordance with a receiver implementation). | 03-07-2013 |
20130053329 | METHODS OF INHIBITING APOPTOSIS OR INFLAMMATION IN A MAMMAL BY ADMINISTERING AN ISOLATED BCL PROTEIN - In one aspect the present invention provides methods for inhibiting cell death or inflammation in a mammal, wherein the methods each include the step of administering to a mammal a Bcl protein in an amount sufficient to inhibit cell death or inflammation in the mammal. The invention also provides methods for identifying a Bcl protein that inhibits cell death or inflammation when administered to a mammal. | 02-28-2013 |
20130043422 | METHODS FOR FORMING LEAD ZIRCONATE TITANATE NANOPARTICLES - Methods for forming lead zirconate titanate (PZT) nanoparticles are provided. The PZT nanoparticles are formed from a precursor solution, comprising a source of lead, a source of titanium, a source of zirconium, and a mineraliser, that undergoes a hydrothermal process. The size and morphology of the PZT nanoparticles are controlled, in part, by the heating schedule used during the hydrothermal process. | 02-21-2013 |
20130039998 | COMPOSITIONS OF MODULATORS OF THE WNT/BETA-CATENIN PATHWAY AND BENZAMIDE AND/OR HYDROXAMIC ACID DERIVATIVES TO TREAT BIPOLAR DISORDER - The present invention is directed to a composition comprising a modulator of the Wnt/β-catenin pathway, such as a GSK-3 inhibitor, or a pharmaceutically acceptable salt thereof either with a benzamide derivative or a pharmaceutically acceptable salt thereof or with a hydroxamic acid or a pharmaceutically acceptable salt thereof. The present invention is also directed to a method of treating bipolar disorder in a subject by administering either a benzamide derivative or a hydroxamic acid to the subject under conditions effective to treat a bipolar disorder. A modulator of the Wnt/β-catenin pathway, such as a GSK-3 inhibitor, or a pharmaceutically acceptable salt thereof may also be administered to a subject. | 02-14-2013 |
20130032289 | METHOD FOR JOINING THERMOPLASTIC POLYMER MATERIAL - A method for joining two components includes positioning a thermoplastic polymer portion of a first component adjacent a thermoplastic polymer portion of a second component such that the first and second portions form an interface. At least one of the portions includes a microstructure having a plurality of closed cells, each cell containing a void and each cell having a maximum dimension extending across the void. The method also includes exerting pressure on the thermoplastic polymer portions to form a bond at the interface that holds the portions together. The plurality of closed cells, and especially those adjacent the surface of the thermoplastic polymer portion that form the interface, help isolate thermally and/or chemically the surface from the remainder of the portion. | 02-07-2013 |
20130011425 | RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME - Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 01-10-2013 |
20130011363 | CATIONIC BETAINE PRECURSORS TO ZWITTERIONIC BETAINES HAVING CONTROLLED BIOLOGICAL PROPERTIES - Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, therapeutic agent delivery systems that include the cationic polymers, methods for administering a therapeutic agent using the delivery systems, and methods for making and using the cationic polymers, monomers, surfaces, and therapeutic agent delivery systems. | 01-10-2013 |
20120322891 | RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF - Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided. | 12-20-2012 |
20120316426 | IMAGE GUIDED HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF NERVES - A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures. | 12-13-2012 |
20120315270 | RSV IMMUNOGENS, ANTIBODIES AND COMPOSITIONS THEREOF - The present invention provides immunogens that protect against RSV infection. The present invention also provides antibody proteins that protect against RSV infection. Such immunogens and antibody proteins are produced based on three-dimensional models also included in the invention. One model is of a complex between motavizumab and its antibody-binding domain on RSV fusion (F) protein. A second model is of a complex between 10 IF antibody and its antibody-binding domain on RSV F protein. The immunogens disclosed herein have been modified to elicit a humoral response against RSV F protein without eliciting a significant cell-mediated response against RSV. Such immunogens can comprise a scaffold into which RSV contact residues are embedded. The present invention also includes methods that utilize the disclosed three-dimensional models to produce immunogens and antibody proteins of the present invention. Also disclosed are methods of using the disclosed immunogens, for example to protect individuals from RSV infection. Also disclosed are methods of using the disclosed antibody proteins, for example to protect individuals from RSV infection. | 12-13-2012 |
20120302938 | DRAINAGE SYSTEMS FOR EXCESS BODY FLUIDS AND ASSOCIATED METHODS - Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter having an exterior surface, a proximal portion, and a distal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor. | 11-29-2012 |
20120302927 | METHODS FOR CHARACTERIZING NONLINEAR FIELDS OF A HIGH-INTENSITY FOCUSED ULTRASOUND SOURCE AND ASSOCIATED SYSTEMS AND DEVICES - The present technology is directed to methods for characterizing nonlinear ultrasound fields and associated systems and devices. In several embodiments, for example, a method of calculating output of a high intensity focused ultrasound (HIFU) device comprises treating a target site with a multi-element HIFU array. In some embodiments, the array comprises a generally spherical segment. The method can further include simulating a field of the array by setting a boundary condition for the array. The boundary condition can be set by simplifying at least one geometrical aspect of the generally spherical segment. | 11-29-2012 |
20120302586 | ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE - Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: | 11-29-2012 |
20120301492 | COMPOSITIONS AND METHODS FOR WT1 SPECIFIC IMMUNOTHERAPY - Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases. | 11-29-2012 |
20120295340 | SEPARATION AND CONCENTRATION OF BIOLOGICAL CELLS AND BIOLOGICAL PARTICLES USING A ONE-DIMENSIONAL CHANNEL - This document discloses, among other things, a method and system for a substrate having a bypass region for fluid flow. The substrate includes a plurality of fluid flow channels with each channel configured to concurrently allow fluid flow while precluding passage of a target particle or object. | 11-22-2012 |
20120288961 | CAPILLARITY-BASED DEVICES FOR PERFORMING CHEMICAL PROCESSES AND ASSOCIATED SYSTEMS AND METHODS - The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a base configured to receive one or more fluids, a porous wick carried by the base portion, and a flow-metering element along the porous wick to modify a rate or volume of fluid flow along the porous wick. The porous wick can comprise a first pathway, a second pathway, and an intersection at which the first pathway and the second pathway converge. Input ends of the first and second pathways can be wettably distinct. Upon wetting of the input ends, fluid is configured to travel by capillary action along each pathway. The device may also include volume-metering features configured to automatically and independently control or modify a volume of fluid flow along one or more pathways of the porous wick. | 11-15-2012 |
20120287129 | FUNCTION-BASED REPRESENTATION OF N-DIMENSIONAL STRUCTURES - A method for modeling an object, particularly suited to complex objects such as anatomical objects, and manipulating the modeled object in a CAD environment includes obtaining volumetric scan data of a region and segmenting the scan data to identify a first object to produce a first set of signed distance values on a grid. Wavelet analysis of the first set of signed distance values provides a function-based representation of the object. A signed distance value model of a second object is obtained, and one or both sets of signed distance values are manipulated to perform a CAD operation. | 11-15-2012 |
20120283409 | COMPUTATIONALLY DESIGNED INHIBITORS OF AMYLOIDOSIS - Embodiments of the present invention include methods and systems for designing inhibitors of amyloidosis in humans, domesticated animals, and wild animals as well as inhibitors of amyloidosis designed by the methods and systems. Methods and systems for designing inhibitors of amyloidosis are largely computational, in nature, and are directed to designing various types of polymers, small-molecule organic compounds, organometallic compounds, or non-chemical physical processes that can target the extended-α-strand and α-sheet regions of amyloidogenic protein and polypeptide intermediates in order to prevent aggregation of those intermediates into protofibrils and fibrils that, in turn, recruit additional native-conformation proteins and polypeptides into amyloidogenic intermediates and that additionally aggregate to form higher-order structures, such as plaques observed in the brains of patients suffering from the various spongiform encephalopathies. | 11-08-2012 |
20120271622 | USE OF LEXICAL TRANSLATIONS FOR FACILITATING SEARCHES - A translation graph is created using a plurality of reference sources that include translations between a plurality of different languages. Each entry in a source is used to create a wordsense entry, and each new word in a source is used to create a wordnode entry. A pair of wordnode and wordsense entries corresponds to a translation. In addition, a probability is determined for each wordsense entry and is decreased for each translation entry that includes more than a predefined number of translations into the same language. Bilingual translation entries are removed if subsumed by a multilingual translation entry. Triangulation is employed to identify pairs of common wordsense translations between a first, second, and third language. Translations not found in reference sources can also be inferred from the data comprising the translation graph. The translation graph can then be used for searches of a data collection in different languages. | 10-25-2012 |
20120270271 | Toxin-Immunity System - The present invention provides host cells whose survivability can be conditionally controlled, and vectors that can be used for preparing such host cells and for selectable cloning. | 10-25-2012 |
20120269855 | TOLL-LIKE RECEPTOR 5 LIGANDS AND METHODS OF USE - The invention provides methods to elicit an immune response with an immunomodulatory flagellin polypeptide having toll-like receptor 5 (TLR5) binding, and further comprising an ADCC targeting molecule. | 10-25-2012 |
20120259250 | METHODS OF SOFT TISSUE EMULSIFICATION USING A MECHANISM OF ULTRASONIC ATOMIZATION INSIDE GAS OR VAPOR CAVITIES AND ASSOCIATED SYSTEMS AND DEVICES - The present technology is directed to methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities, and associated systems and devices. In several embodiments, for example, a method of non-invasively treating tissue includes pulsing ultrasound energy from the ultrasound source toward the target site in tissue. The ultrasound source is configured to emit high intensity focused ultrasound (HIFU) waves. The target site comprises a pressure-release interface of a gas or vapor cavity located within the tissue. The method continues by generating shock waves in the tissue to induce a lesion in the tissue at the target site. The method additionally includes characterizing the lesion based on a degree of at least one of a mechanical or thermal ablation of the tissue. | 10-11-2012 |
20120253360 | MOTION AND VIDEO CAPTURE FOR TRACKING AND EVALUATING ROBOTIC SURGERY AND ASSOCIATED SYSTEMS AND METHODS - The present technology is directed to motion and video capture for tracking and evaluating robotic surgery. In one embodiment, the system includes at least one tracking device coupled to a remote surgical tool. The tracking device is configured to use one or more sensors to sense one or more physical variables such as movement and electrical contact. In some embodiments, the data from multiple individual sensors is synchronized, received, and stored by a digital information system. The digital information system is configured to analyze the data to objectively assess surgical skill. | 10-04-2012 |
20120252995 | DIELS-ALDER CROSSLINKABLE DENDRITIC NONLINEAR OPTIC CHROMOPHORES AND POLYMER COMPOSITES - Diels-Alder crosslinkable dendritic nonlinear optical chromophore compounds, films and crosslinked polymer composites formed from the chromophore compounds, methods for making and using the chromophore compounds, films, and crosslinked polymer composites, and electro-optic devices that include films and crosslinked polymer composites formed from the chromophore compounds. | 10-04-2012 |
20120245444 | WIRELESS POWERED CONTACT LENS WITH GLUCOSE SENSOR - A contact lens having an integrated glucose sensor is provided. The contact lens includes an electrochemical sensor configured to measure the level of glucose in the tear fluid of the eye of the user wearing the contact lens. The electrochemical sensor is powered by radiation off-lens, through an RF antenna or a photovoltaic device mounted on the periphery of the contact lens. The power provided to the contact lens also enables transmission of data from the electrochemical sensor, for example by backscatter communications or optically by an LED mounted to the lens. | 09-27-2012 |
20120237523 | NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE - Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes. | 09-20-2012 |
20120220006 | HYDROGEN PRODUCTION FROM MICROBIAL STRAINS - The present invention is directed to a method of screening microbe strains capable of generating hydrogen. This method involves inoculating one or more microbes in a sample containing cell culture medium to form an inoculated culture medium. The inoculated culture medium is then incubated under hydrogen producing conditions. Once incubating causes the inoculated culture medium to produce hydrogen, microbes in the culture medium are identified as candidate microbe strains capable of generating hydrogen. Methods of producing hydrogen using one or more of the microbial strains identified as well as the hydrogen producing strains themselves are also disclosed. | 08-30-2012 |
20120208313 | METHODS OF FORMING AGGREGATE PARTICLES OF NANOMATERIALS - Methods for forming aggregates of nanomaterials are provided. The aggregates are formed from a liquid dispersion of the nanomaterials in a liquid. The dispersion is aerosolized and the liquid removed from the aerosolized dispersion to provide the aggregates. The aggregates are useful as a photoelectric layer and/or a light-dispersive layer in dye-sensitized solar cells. | 08-16-2012 |
20120202314 | SOLAR CELLS BASED ON POLYMER NANOWIRES - Solar cells having active layers that include poly(3-alkylthiophene) nanowires. | 08-09-2012 |
20120195004 | Porous Thermoplastic Foams as Heat Transfer Materials - Interconnected, open-celled porous or microporous polymeric foams are used for the preparation of heat transfer devices. The use of such porous polymeric foams can generate a turbulent flow within a heat exchanging liquid, thus enabling increased heat transfer to and from the fluid. The present disclosure provides devices having a heat transfer element containing a heat exchange region wherein a heat exchange fluid can be circulated through a porous polymeric foam; and method for making and using such devices. | 08-02-2012 |
20120179075 | EXOSKELETON - This document discloses, among other things, a wearable structure having links and joints corresponding to those of a human upper body. Transducers are located on the wearable structure and are coupled to a processor. The transducers exchange energy and information between the user and the wearable structure and enable control of the movement of the structure. | 07-12-2012 |
20120172721 | MULTILAYER ULTRASOUND TRANSDUCER DEVICES FOR HIGH POWER TRANSMISSION AND WIDE-BAND RECEPTION AND ASSOCIATED SYSTEMS AND METHODS - Multilayer ultrasound transducer devices for high power transmission and wide-band reception and associated methods and systems are disclosed herein. An ultrasound transducer device in accordance with an embodiment of the present technology, for example, can include a first array of first transducers and a second array of second transducers that are oriented substantially parallel to one another. The first transducers can include a first piezoelectric material that is configured to transmit acoustic waves, and the second transducers can include a second piezoelectric material that is configured to receive echoes from the acoustic waves. The ultrasound transducer device can further include an electrical connection layer between the first and second arrays that is electrically coupled to the first and second transducers. | 07-05-2012 |
20120172419 | REAGENTS AND METHODS FOR MODULATING CONE PHOTORECEPTOR ACTIVITY - The present invention provides reagents and methods for modulating cone photoreceptor activity, and devices for assessment of cone photoreceptor activity. | 07-05-2012 |
20120171698 | METHOD AND DEVICE FOR RAPID PARALLEL MICROFLUIDIC MOLECULAR AFFINITY ASSAYS - Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume flowing through a single channel. | 07-05-2012 |
20120169770 | Navigating Images Using Image Based Geometric Alignment And Object Based Controls - Over the past few years there has been a dramatic proliferation of digital cameras, and it has become increasingly easy to share large numbers of photographs with many other people. These trends have contributed to the availability of large databases of photographs. Effectively organizing, browsing, and visualizing such .seas. of images, as well as finding a particular image, can be difficult tasks. In this paper, we demonstrate that knowledge of where images were taken and where they were pointed makes it possible to visualize large sets of photographs in powerful, intuitive new ways. We present and evaluate a set of novel tools that use location and orientation information, derived semi-automatically using structure from motion, to enhance the experience of exploring such large collections of images. | 07-05-2012 |
20120169734 | Navigating Images Using Image Based Geometric Alignment And Object Based Controls - Over the past few years there has been a dramatic proliferation of digital cameras, and it has become increasingly easy to share large numbers of photographs with many other people. These trends have contributed to the availability of large databases of photographs. Effectively organizing, browsing, and visualizing such .seas. of images, as well as finding a particular image, can be difficult tasks. In this paper, we demonstrate that knowledge of where images were taken and where they were pointed makes it possible to visualize large sets of photographs in powerful, intuitive new ways. We present and evaluate a set of novel tools that use location and orientation information, derived semi-automatically using structure from motion, to enhance the experience of exploring such large collections of images. | 07-05-2012 |
20120152336 | AGGREGATE PARTICLES OF TITANIUM DIOXIDE FOR SOLAR CELLS - Aggregate particles comprising titanium dioxide (TiO | 06-21-2012 |
20120145890 | Methods And Systems For Mass Spectrometry - The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI. | 06-14-2012 |
20120143077 | MEASUREMENT AND USE OF IN-SOCKET RESIDUAL LIMB VOLUME CHANGE DATA FOR PROSTHETIC FITTING - Changes in the volume of residual limbs on which prosthetic sockets are worn can be measured based on bioimpedance measurements along one or more segments of the limb. A current at an appropriate frequency (e.g., in the range from 1 kHz to 1 MHz) is injected at two current electrodes that contact the skin of the residual limb. The voltage at the voltage electrodes disposed between the current electrodes is measured and using an appropriate model, the change in the segmented volume of the limb can be determined during periods of different activity and at different times during the day. This information can be used for assessing the fit of the socket and can also provide a feedback signal for automatically controlling volume management devices, to ensure a more comfortable fit when the volume of the limb is changing. | 06-07-2012 |
20120142077 | SYNTHETIC ENZYMES DERIVED FROM COMPUTATIONAL DESIGN - Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used to identify potential protein backbone structures (i.e., scaffolds) capable of supporting the required functional sites. These techniques were used to design 32 different protein sequences that exhibited aldol reaction catalytic function, 31 of which are defined in the Sequence Listing. Details of these 31 different synthetic aldolases are provided, including descriptions of how such synthetic aldolases can be differentiated from naturally occurring aldolases. | 06-07-2012 |
20120141558 | ALGINATE-BASED NANOFIBERS AND RELATED SCAFFOLDS - Alginate nanofibers, scaffolds that include alginate nanofibers, implantable devices that include alginate nanofibers, and methods for making the alginate nanofibers by electrospinning. | 06-07-2012 |
20120138804 | LINE OF RESPONSE ESTIMATION FOR HIGH-RESOLUTION PET DETECTOR - A method for estimating a line or response in a positron emission tomography scanner having depth of interaction estimation capability. The method utilizes information from both detector modules detecting a coincident event. A joint probability density function combining factors accounting for intermediate Compton scattering interactions and/or a final interaction that may be either a Compton scattering interaction or photoelectric absorption is calculated. In a preferred embodiment, a Bayesian estimation scheme is used to integrate the PDF for all permutations of the measured signal pairs, and the permutation with the largest joint probability is selected to construct the estimated line of response. | 06-07-2012 |
20120138469 | MICROFLUIDIC DEVICES FOR TRANSVERSE ELECTROPHORESIS AND ISOELECTRIC FOCUSING - Devices and methods are provided for separation of particles of a first selected electrophoretic mobility or isoelectric point from a fluid comprising particles of at least one other selected electrophoretic mobility or isoelectric point. The devices comprise a microchannel; electrodes to either side of the microchannel for applying a selected voltage to produce an electrical field across the microchannel orthogonal to the length of the microchannel; and outlets in said microchannel placed to receive outlet portions of the fluid containing enhanced concentrations of each type of particle. The devices may be used for particle detection, quantification, separation, mixing, dilution and concentration; to release, separate and detect interior particles of cells or organisms, and to separate particles such as proteins and microorganisms from biological fluids such as blood; or to separate and detect airborne contaminants such as bacterial warfare agents from air. | 06-07-2012 |
20120128227 | DEVICE FOR GENERATING ALTERNATIVE OF NORMAL BRAIN DATABASE | 05-24-2012 |
20120118052 | METHOD AND SYSTEM FOR BACKGROUND SUPPRESSION IN MAGNETO-MOTIVE PHOTOACOUSTIC IMAGING OF MAGNETIC CONTRAST AGENTS - Method and system for background suppression in magneto-motive photoacoustic imaging of labeled target objects. | 05-17-2012 |
20120112170 | CROSS-CONJUGATED POLYMERS FOR ORGANIC ELECTRONIC DEVICES AND RELATED METHODS - Cross-conjugated donor-acceptor polymers, methods for their preparation, devices that include polymers, and methods for the preparation and use of the devices. | 05-10-2012 |
20120100594 | ENZYME CATALYSTS FOR DIELS-ALDER REACTIONS - The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other aspects, the invention provides methods of making the enzyme catalysts, including by de novo computational design. The present invention thereby provides enzyme catalysts capable of catalyzing a desired Diels-Alder reaction, including with a specified or desired stereo-selectivity. | 04-26-2012 |
20120094285 | Ratiometric Pre-rRNA Analysis - Disclosed are compositions and methods for detecting the presence of viable cells in a sample. Included are compositions and methods for increasing the sensitivity of a nucleic acid amplification test for determining the presence of at least one target microorganism in a sample. Also disclosed are compositions and methods for detecting ribosomal RNA precursors (pre-rRNA) as dynamic indicators of viable microorganisms in a sample. | 04-19-2012 |
20120093790 | HLA HOMOZYGOUS CELLS AND METHODS OF USE THEREOF - The present invention provides methods of generating a mammalian cell that is homozygous at a locus of interest, as well as cells made by the method. The present invention further provides methods of using the cells. | 04-19-2012 |
20120087857 | GADOLINIUM EXPRESSED LIPID NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING - Lipid nanoparticles expressing metal ions and methods for using the compositions for magnetic resonance imaging. | 04-12-2012 |
20120079628 | COMPOSITIONS AND METHODS FOR MODULATION OF PLANT CELL DIVISION - The present invention provides compositions and methods for modulating cell division in plants. In particular, the present invention provides polynucleotides that encode REVOLUTA. In addition, REVOLUTA vectors and transformed plants are provided wherein plant cell division is modulated by expression of a REVOLUTA transgene as compared to a control population of untransformed plants. The present invention also provides methods for the isolation and identification of REVOLUTA genes from higher plants. | 03-29-2012 |
20120070890 | TARGETED GENE MODIFICATION BY PARVOVIRAL VECTORS - This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing. | 03-22-2012 |
20120067390 | METHOD AND SYSTEM FOR GENERATING ELECTRICAL ENERGY FROM WATER - Method and system for generating electrical energy from a volume of water. | 03-22-2012 |
20120059697 | ADVERTISING DURING ACCELERATED MEDIA PLAYBACK - A system and a method are disclosed for displaying an image during an operation of an accelerated media playback (e.g., fast-forward or reverse) such that the image appears concurrently with a cue signaling a resume point. First, a video frame within an advertisement is identified from a plurality of advertisements. The video frame contains the cue and indicates a resume point for media content. Additionally, an image is embedded on the video frame such that the video frame, the cue and the image are displayed for less than a second during accelerated media playback, such as a fast-forward operation. The presence of the action cue or resume cue presented concurrently with the advertisement assists viewers in preferentially recalling the product related to the image. | 03-08-2012 |
20120059021 | COMPOSITIONS AND METHODS FOR TREATING CANCER AND METHODS FOR PREDICTING A RESPONSE TO SUCH TREATMENTS - The present disclosure relates to the regulation and function of the Wnt/β-catenin signaling pathway and the ERK signaling pathway. The disclosure provides methods of treatment for melanoma by administering both an inhibitor of ERK signaling and an activator of Wnt/β-catenin signaling. These methods may be used alone or in combination with other strategies targeting melanoma cell survival. The disclosure also provides diagnostic methods for predicting a patient's clinical response to inhibitors of ERK signaling. | 03-08-2012 |
20120055792 | MSP NANOPORES AND RELATED METHODS - Provided herein are | 03-08-2012 |
20120046242 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY - The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject a compound selected from the group consisting of those set forth in Table 1, Table 2, and a pharmaceutically acceptable salt thereof. A method of similarly modulating the Wnt/β-catenin pathway in a subject is also discussed. | 02-23-2012 |
20120041073 | STABILIZED MUTANT OPSIN PROTEINS - Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids. | 02-16-2012 |
20120040916 | MOLECULAR INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY - The present invention is directed toward a method of treating a subject for a condition mediated by the Wnt/β-catenin pathway by selecting a subject with a condition mediated by the Wnt/β-catenin pathway and administering to the selected subject a compound selected from the group consisting of those set forth in Table 1, Table 2, and a pharmaceutically acceptable salt thereof. A method of similarly inhibiting the Wnt/β-catenin pathway in a subject is also disclosed. | 02-16-2012 |
20120038881 | FREE-STANDING TWO-SIDED DEVICE FABRICATION - Solar cells attached to a contact lens are provided, as well as methods for making the solar cells and contact lenses. The solar cells have electrodes on only one side of the device, which facilitates attachment of the solar cell to a contact lens. In one embodiment, the solar cells are made using a “two sided” process. By using the two-sided process, solar cells of only a few microns in thickness can be fabricated. Such relatively thin solar cells can be incorporated into a contact lens without discomfort to the wearer. By providing an infinitely renewable power source on a contact lens, the solar cells enable the use of electronic components on the contact lens while eliminating the recharging or replacing issues that arise with batteries. | 02-16-2012 |
20120028793 | DUAL-OXIDE SINTER RESISTANT CATALYST - A catalyst material for use at elevated temperatures is provided. The material can include a plurality of fibers and a plurality of particles supported on the fibers. In addition, a porous layer can cover the plurality of particles and allow for process fluid to come into contact with the particles, and yet retard sintering of the particles at elevated temperatures is present. The plurality of fibers can be a plurality of nanofibers which may or may not be oxide nanofibers. The particles can be metallic nanoparticles and the porous layer can be a porous oxide layer. | 02-02-2012 |
20120027790 | IMMUNOLOGICAL HERPES SIMPLEX VIRUS ANTIGENS AND METHODS FOR USE THEREOF - The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 02-02-2012 |
20120027789 | ANTIGENIC PEPTIDE OF HSV-2 AND METHODS FOR USING SAME - The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV, The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 02-02-2012 |
20120021514 | HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY - Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent. | 01-26-2012 |
20120009292 | METHOD AND APPARATUS FOR CONTROLLED ELECTROSPINNING - An electrospinning apparatus and methodology is described that produces medical devices, such as scaffolds that induce the formation of a natural fibrous structure (primarily collagen and elastin) in a tissue-engineered medical device. The apparatus uses collection surfaces designed to manipulate or change the electrostatic field so that the electrospun fibers are arranged in desirable patterns that are similar to or mimic the fibrillar structure of an animal tissue. The manipulation results in fibers that are preferentially oriented in a predefined pattern. In addition, the interfiber space between the fibers and the fiber diameter are consistently within a predefined range. Using these techniques in conjunction with controlling polymer properties enables the production of a scaffold that has the structural and mechanical characteristics similar to the native tissue. | 01-12-2012 |
20110320927 | Methods and Apparatus Utilizing XooML: Cross (X) Tool Markup Language - Methods and apparatus are presented related to one or more cross-tool markup language (XooML) fragments. A document including a XooML fragment is assembled. A XooML fragment includes tool-independent attribute(s) and tool-dependent attribute(s). The document is presented. A selection of a portion of the presented document is received. The selected portion of the document corresponds with an associated XooML fragment. In response to the selection, an item is presented that corresponds to the selected portion of the document. The item can be presented using a software tool such as the herein-described Planz or by another XooML-capable software tool. A tool-independent attribute of the associated XooML fragment specifies the item. The software tool is configured to present the item based on one or more tool-dependent attributes of the XooML fragment. | 12-29-2011 |
20110305660 | OMEGA-FUNCTIONALIZED POLYMERS, JUNCTION-FUNCTIONALIZED BLOCK COPOLYMERS, POLYMER BIOCONJUGATES, AND RADICAL CHAIN EXTENSION POLYMERIZATION - Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective co-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization. | 12-15-2011 |
20110302694 | CLINICAL FORCE SENSING GLOVE - A clinical sensing glove system to quantify force, shear, hardness, etc., measured in manual therapies is disclosed. A sensor is disposed in a clinical glove. The sensor undergoes micro-bending, macro-bending, evanescent coupling, a change in resonance, a change in polarization, a change in phase modulation, in response to pressure/force applied. The amount of micro-bending, macro-bending, evanescent coupling, change in resonance, change in polarization, and/or change in phase modulation is proportional to the intensity of the pressure/force. A clinician can quantitatively determine the amount of pressure, force, shear, hardness, rotation, etc., applied. | 12-15-2011 |
20110299089 | COMPACT LIQUID CRYSTAL BASED FOURIER TRANSFORM SPECTROMETER SYSTEM - Systems and methods for a compact Fourier transform spectrometer. A cell having two transparent walls and containing a liquid crystal medium is placed in a light beam. Applying a voltage across the cell causes the liquid crystal molecules to orient at a certain angle, wherein the angle is a function of the voltage applied. The refractive index if the cell is dependent upon the orientation of the liquid crystal molecules, and from the refractive index of the cell an optical path difference between ordinary and extraordinary waves can be calculated. Accordingly, any suitable optical path difference can be achieved by varying the voltage across the cell for a Fourier transform analysis. | 12-08-2011 |
20110293750 | ACTIVATED WNT-BETA-CATENIN SIGNALING IN MELANOMA - The present invention is directed to a method of determining the prospects for survival of a melanoma patient. This method involves providing a biological sample from a patient diagnosed with melanoma, determining the level of an indicator of Wnt/β-catenin activation in the sample, comparing the level of the indicator of Wnt/β-catenin activation in the sample against a standard level of the indicator of Wnt/β-catenin activation correlated to survival of melanoma, and determining a patient's prospects for survival of melanoma based on the comparison. The present invention also relates to a method of improving survival of melanoma patients, decreasing metastases in melanoma patients, decreasing proliferation of cancer cells in melanoma patients, decreasing melanoma recurrence in melanoma patients, and/or decreasing tumor size in melanoma patients. This involves selecting melanoma patients and subsequently determining and monitoring therapy based on their level of Wnt/β-catenin activation. The selected melanoma patients are treated with a dose of an activator or synergizer of Wnt/β-catenin based on the patient's level of Wnt/β-catenin, under conditions effective, respectively, to improve survival of the selected melanoma patients, to decrease metas-tases in the selected melanoma patients, to decrease proliferation of cancer cells in the selected melanoma patients, to decrease melanoma recurrence in the selected melanoma patients, and/or to decrease tumor size in the selected melanoma patients. | 12-01-2011 |
20110288448 | PROSTHETIC LIMB MONITORING SYSTEM - Parameters related to use of a prosthesis by a patient with a limb amputation are monitored using a tool that includes one or more piezoelectric force sensors. The resulting data are processed for use both in short and long term management of amputee patients. The sensor is a small modular unit that fits within or between traditional prosthetic components, e.g., below a prosthesis socket. The data produced by the tool are collected, processed, and stored. Optionally, the data are periodically communicated to a remote site via a network, e.g., over the Internet. The device and associated software used to process the data can be used to characterize activities conducted by a prosthesis user, to determine pistoning or threatening interface stress distributions between the limb and socket, mal-alignment of the socket, use of improper components, and other possibly undesired conditions that the amputee patient using the prosthesis may be experiencing. | 11-24-2011 |
20110288281 | METHOD FOR 2-SULFATION OF GLYCOSIDES - Method for selective 2-sulfation of glycosides. | 11-24-2011 |
20110288238 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophoresis can also be used with the disrupting agents. | 11-24-2011 |
20110288170 | RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS - Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided. | 11-24-2011 |
20110287078 | NOVEL POROUS BIOMATERIALS - The invention provides porous biomaterials and methods for forming porous biomaterials. The porous biomaterials of the invention comprise a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores. The invention also provides implantable devices comprising a layer of a biomaterial, and methods for promoting angiogenesis in and around an implantable biomaterial. | 11-24-2011 |
20110286957 | MULTIBLOCK COPOLYMERS - Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof. | 11-24-2011 |
20110282005 | SUPER-LOW FOULING SULFOBETAINE MATERIALS AND RELATED METHODS - Super-low fouling sulfobetaine and carboxybetaine materials, super-low fouling surfaces and methods of making the surfaces coated with sulfobetaine and carboxybetaine materials, and devices having the super-low fouling surfaces. | 11-17-2011 |
20110281934 | MICELLES OF HYDROPHILICALLY SHIELDED MEMBRANE-DESTABILIZING COPOLYMERS - Provided herein are micelles comprising a plurality of copolymers. In certain instances, micelles provided herein are pH sensitive particles. | 11-17-2011 |
20110281354 | BISPECIFIC INTRACELLULAR DELIVERY VEHICLES - A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target. | 11-17-2011 |
20110269943 | RADIOLABELED ANNEXINS - Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided. | 11-03-2011 |
20110267604 | CYTOMETER WITH AUTOMATIC CONTINUOUS ALIGNMENT CORRECTION - A system and method for performing flow cytometry is disclosed wherein the alignment of the light source with respect to the sensing region of the fluid stream is continuously controlled using a feedback control loop. An imaging apparatus is provided that images the system along the optical axis, between the field stop and the sensing region. In an embodiment, the cytometer includes a field stop having an H-shaped aperture and light diverters over the ends of the aperture that divert a portion of the light to peripheral detectors. | 11-03-2011 |
20110266492 | STIMULI-RESPONSIVE MAGNETIC NANOPARTICLES AND RELATED METHODS - Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles. | 11-03-2011 |
20110257894 | METHOD FOR DECONVOLVING SINGLE-MOLECULE INTENSITY DISTRIBUTIONS FOR QUANTITATIVE BIOLOGICAL MEASUREMENTS - A method for quantifying fluorescent puncta comprising acquiring at least one first intensity distribution comprising fluorescence intensity values from a plurality of first fluorescent puncta; acquiring at least one second intensity distribution comprising fluorescence intensity values from a plurality of second fluorescent puncta, wherein each second fluorescent puncta has a determined number of fluorescent emitters; determining the relationship between the first and second intensity distributions; and fitting the second intensity distribution to the first intensity distribution to provide a count and distribution of the number of fluorescent emitters within the first fluorescent puncta. | 10-20-2011 |
20110251917 | PERFORMING PREDICTIVE PRICING BASED ON HISTORICAL DATA - Techniques are described for using predictive pricing information for items to assist in evaluating buying and/or selling decisions in various ways, such as on behalf of end-user item acquirers and/or intermediate item providers. The predictive pricing for an item may be based on an analysis of historical pricing information for that item and/or related items, and can be used to make predictions about future pricing information for the item. Such predictions may then be provided to users in various ways to enable comparison of current prices to predicted future prices. In some situations, predictive pricing information is used to assist customers when purchasing airline tickets and/or to assist travel agents when selling airline tickets. This abstract is provided to comply with rules requiring an abstract, and it is submitted with the intention that it will not be used to interpret or limit the scope or meaning of the claims. | 10-13-2011 |
20110251528 | METHODS AND SYSTEMS FOR NON-INVASIVE TREATMENT OF TISSUE USING HIGH INTENSITY FOCUSED ULTRASOUND THERAPY - Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue. | 10-13-2011 |
20110251272 | METHODS AND COMPOSITIONS FOR PREDICTING DRUG RESPONSES - The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene. | 10-13-2011 |
20110251144 | MOLECULAR MODULATORS OF THE WNT/BETA-CATENIN PATHWAY - The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject at least one compound selected from the group consisting of those set forth in Table 1, Table 2, Table 3, and a pharmaceutically acceptable salt thereof. A method of similarly modulating the Wnt/β-catenin pathway in a subject is also discussed. | 10-13-2011 |
20110250146 | MAGNETIC NANOPARTICLE AND METHOD FOR IMAGING T CELLS - The present invention provides nanoparticles having a core comprising a magnetic material and having a surface, where the surface may be operatively linked to an antigenic peptide-major histocompatibility complex (MHC) monomer. The antigenic peptide-MHC monomer may then be recognized by a T cell receptor. These nanoparticles may further comprise a signal-generating label, such as a fluorophore. Methods employing nanoparticles of the present invention may involve magnetic resonance imaging and/or fluorescence detection, such that cell imaging and localization are performed. | 10-13-2011 |
20110244452 | SEQUENCE DATA BY REDUCTION OF NOISE DUE TO CARRY-OVER PRIMER - The present invention provides methods of reducing the background signal of a nucleic acid sequencing reaction. In particular, the invention provides methods of specifically degrading unwanted chain termination reaction products generated by the extension of primers carried over from the amplification step of the sequencing reaction. These methods are amenable for use with both one step and two-step amplification/chain termination reaction sequencing protocols. | 10-06-2011 |
20110230433 | COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER - Described herein are novel methods and compositions for treatment of cancer by increasing the mutation rate of cancer cells beyond an error threshold, over which the cancer cells are no longer viable. In particular, mutagenic compounds such as nucleoside analogs for treatment of cancer are also described herein. | 09-22-2011 |
20110215248 | IMPROVED DATA-PROCESSING ELECTRONICS FOR USE IN A POSITRON-EMISSION TOMOGRAPHY SYSTEM - Improved processing electronic hardware are disclosed that facilitate the efficient processing of PET system data, while enhancing accuracy and compatibility of PET systems with other analytical methods (e.g., magnetic resonance imaging). Improvements include the use of an application-specific integrated circuit (ASIC) for summing, by row, column, and diagonal, the output signals from an array of photodetectors in the PET system | 09-08-2011 |
20110212477 | LIPOPROTEIN-ASSOCIATED MARKERS FOR CARDIOVASCULAR DISEASE - The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop, or is suffering from, cardiovascular disease. The methods comprise detecting an amount of at least one biomarker in a biological sample, or HDL subfraction thereof, from the subject, and comparing the detected amount of the biomarker to a predetermined value, where a difference between the detected amount and the predetermined value is indicative of the presence or risk of cardiovascular disease in the subject. In some embodiments, the biomarker comprises at least one of ApoC-IV, Paraoxonase 1, C3, C4, ApoA-IV, ApoE, ApoL1, C4B1, Histone H2A, ApoC-II, ApoM, Vitronectin, Haptoglobin-related protein, and Clusterin, or combinations thereof. | 09-01-2011 |
20110207820 | NOVEL CHRYSOCHROMULINA SPECIES, METHODS AND MEDIA THEREFOR, AND PRODUCTS DERIVED THEREFROM - An algal cell that is capable of surviving in fresh water and has a high fatty acid content, an algal culture including the algal cell, methods of growing the algal culture, algal growth media, and methods for selectively adapting the algal culture are provided. | 08-25-2011 |
20110202140 | LOAD BEARING IMPLANTS WITH ENGINEERED GRADIENT STIFFNESS AND ASSOCIATED SYSTEMS AND METHODS - Implants are made of materials having asymmetric modulus gradients. For example, an implant, such as a hip implant, is made of a material having a stiffness gradient between a proximal portion near a hip joint and a distal portion extending downward into the marrow of the femur. Among other benefits, the asymmetric modulus gradient mitigates problems associated with stress shielding and does not excessively wear or deteriorate the proximal portion of the implant. | 08-18-2011 |
20110201929 | METHOD FOR USING HIGH INTENSITY FOCUSED ULTRASOUND - A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface. | 08-18-2011 |
20110199716 | ELECTRIC DOUBLE LAYER CAPACITANCE DEVICE - The present application is directed to electric double layer capacitance (EDLC) devices. In one aspect, the present application is directed to an electrode comprising an activated carbon cryogel having a tunable pore structure wherein: the surface area is at least 1500 m2/g as determined by nitrogen sorption at 77K and BET analysis; and the pore structure comprises a pore volume ranging from about 0.01 cc/g to about 0.25 cc/g for pores having a pore diameter of 0.6 to 1.0 nm. In another aspect, the present application is directed to an Electric Double Layer Capacitor (EDLC) device comprising an activated cryogel. | 08-18-2011 |
20110195104 | INTEGRATED ANTIMICROBIAL AND LOW FOULING MATERIALS - Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, and methods for making and using the cationic polymers and surfaces. The cationic polymers include counterions and/or hydrolyzable groups that release active agents. | 08-11-2011 |
20110176961 | AUTOMATED WORKSTATION FOR DISINFECTING OBJECTS AND METHODS OF USE THEREOF - An automated workstation or apparatus for disinfecting an object in a controlled environment is provided. A method for disinfecting an object in a controlled environment is provided. | 07-21-2011 |
20110170744 | VIDEO-BASED VEHICLE DETECTION AND TRACKING USING SPATIO-TEMPORAL MAPS - Systems and methods for detecting and tracking objects, such as motor vehicles, within video data. The systems and method analyze video data, for example, to count objects, determine object speeds, and track the path of objects without relying on the detection and identification of background data within the captured video data. The detection system uses one or more scan lines to generate a spatio-temporal map. A spatio-temporal map is a time progression of a slice of video data representing a history of pixel data corresponding to a scan line. The detection system detects objects in the video data based on intersections of lines within the spatio-temporal map. Once the detection system has detected an object, the detection system may record the detection for counting purposes, display an indication of the object in association with the video data, determine the speed of the object, etc. | 07-14-2011 |
20110164843 | ENHANCED SILICON ALL-OPTICAL MODULATOR - A single-photon absorption all-optical signal-processing device, systems employing the same, and methods of making and using the same. Illustrative examples are provided based on silicon semiconductor technology that employs rectangular waveguides fabricated on SOI wafers. In some embodiments, it is observed that the waveguides have surface state density, σ, of not less than 1.5×10 | 07-07-2011 |
20110162708 | DYE-SENSITIZED SOLAR CELL EMPLOYING ZINC OXIDE AGGREGATES GROWN IN THE PRESENCE OF LITHIUM - Provided are a novel ZnO dye-sensitized solar cell and method of fabricating the same. In one embodiment, deliberately added lithium ions are used to mediate the growth of ZnO aggregates. The use of lithium provides ZnO aggregates that have advantageous microstructure, morphology, crystallinity, and operational characteristics. Employing lithium during aggregate synthesis results in a polydisperse collection of ZnO aggregates favorable for porosity and light scattering. The resulting nanocrystallites forming the aggregates have improved crystallinity and more favorable facets for dye molecule absorption. The lithium synthesis improves the surface stability of ZnO in acidic dyes. The procedures developed and disclosed herein also help ensure the formation of an aggregate film that has a high homogeneity of thickness, a high packing density, a high specific surface area, and good electrical contact between the film and the fluorine-doped tin oxide electrode and among the aggregate particles. | 07-07-2011 |
20110151574 | DETECTION OF TRACE CHEMICALS AND METHOD THEREFOR - The invention provides devices, systems, and methods for detecting an analyte vapor. Particularly, electronegative analyte vapors, such as those vapors evolving from explosive compounds, are typical analytes detected the devices. The devices operate using a resistivity change mechanism wherein a nanostructured chemiresistive material undergoes a resistivity change in the presence of an analyte vapor. A resistivity change indicates the presence of an analyte. | 06-23-2011 |
20110151557 | COMPOSITIONS AND METHODS FOR TRANSFECTION OF RNA AND CONTROLLED STABILIZATION OF TRANSFECTED RNA - The present invention provides reagents and methods for RNA transfection and protein expression | 06-23-2011 |
20110151479 | MICROFLUIDIC SYSTEMS INCORPORATING FLOW-THROUGH MEMBRANES - Disclosed is a flow-through membrane assay that takes advantage of a high surface area and rapid transport while allowing individual control over flow rates and times for each step of a multi-step assay. A microfluidic card features channels in communication with a porous membrane, channels on either side of membrane to allow transverse flow across the membrane, capturing a labeled target from the sample by flowing the sample across the membrane, or capturing a target from the sample followed by flowing a reagent containing a label that binds to the target. Fluid can be pushed or pulled through the assay membrane by external control. Air near the membrane is managed by diverting air between fluids to a channel upstream of the assay membrane, venting air between fluids through a hydrophobic membrane upstream of the assay membrane, and/or by venting trapped air through a hydrophobic membrane downstream of the assay membrane. | 06-23-2011 |
20110150841 | Secretion System and Methods for its Use - The present invention provides reagents and methods for inhibiting bacterial infection and abnormal cell growth, as well as for selection cloning of nucleic acid inserts. | 06-23-2011 |
20110143435 | POLYMERIC CARRIER - Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell. | 06-16-2011 |
20110143434 | DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS - Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic. | 06-16-2011 |
20110142951 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS - Composition comprising a polymeric micelle and an associated polynucleotide. | 06-16-2011 |
20110135756 | COMPOSITIONS AND METHODS FOR PROTECTING SENSORY HAIR CELLS - The invention provides compounds, compositions and methods that can be used for the attenuation of damage to sensory hair cells and symptoms thereof. More particularly, the invention identifies drugs that can be used to protect sensory hair cells from ototoxic medications, noise-induced damage and age-related loss. | 06-09-2011 |
20110135687 | RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME - Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigen or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 06-09-2011 |
20110129921 | TARGETED POLYMER BIOCONJUGATES - Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer. | 06-02-2011 |
20110128548 | Portable and Cartridge-Based Surface Plasmon Resonance Sensing Systems - This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte. | 06-02-2011 |