University of Washington Center for Commercialization Patent applications |
Patent application number | Title | Published |
20150376645 | SUPERCOILED MINIVECTORS AS A TOOL FOR DNA REPAIR, ALTERATION AND REPLACEMENT - In some embodiments the present disclosure provides a composition for targeted alteration of a DNA sequence and methods of altering the targeted DNA sequence using the composition. In some embodiments such a composition comprises a MiniVector comprising a nucleic acid sequence template for homology-directed repair, alteration, or replacement of the targeted DNA sequence within a cell in vivo or in vitro, where the MiniVector lacks both a bacterial origin of replication and an antibiotic selection gene, and wherein the Mini Vector has a size up to about 2,500 base pairs. | 12-31-2015 |
20150203827 | MODIFIED TAFAZZIN PROTEINS AND METHODS OF MAKING AND USING THE SAME - Fusion proteins comprising a tafazzin peptide and a cellular permeability peptide are disclosed. The tafazzin peptide may be coupled to the permeability peptide through a polypeptide linker. Methods of making and using the fusion proteins are also disclosed. For example, the disclosed fusion proteins may be used to treat a patient having a disorder associated with a tafazzin deficiency or a remodeled cardiolipin deficiency (e.g., Barth syndrome). Additionally, the disclosed fusion proteins may be used in prophylaxis against developing a disorder associated with a tafazzin deficiency or a remodeled cardiolipin deficiency in a patient at risk of developing such a disorder. | 07-23-2015 |
20150030561 | Use of CXCR4 Antagonists - Presently disclosed are methods and compositions for treating or preventing WHIM syndrome and certain other disorders or conditions with a certain CXCR4 antagonist. | 01-29-2015 |
20140094682 | IMAGE GUIDED HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF NERVES - A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures. | 04-03-2014 |
20140056868 | Supercoiled MiniVectors as a Tool for DNA Repair, Alteration and Replacement - In some embodiments the present disclosure provides a composition for targeted alteration of a DNA sequence and methods of altering the targeted DNA sequence using the composition. In some embodiments such a composition comprises a MiniVector comprising a nucleic acid sequence template for homology-directed repair, alteration, or replacement of the targeted DNA sequence within a cell in vivo or in vitro, where the MiniVector lacks both a bacterial origin of replication and an antibiotic selection gene, and wherein the MiniVector has a size up to about 2,500 base pairs. In further embodiments of the present disclosure the nucleic acid sequence template for the homology-directed repair, alteration, or replacement of the targeted DNA sequence comprises at least one portion of the template complementary to a nucleic acid sequence near the targeted DNA sequence to be altered; and at least one portion of the template which is not complementary to the targeted DNA sequence to be altered, wherein the non-complementary portion of the nucleic acid template contains the alteration desired in the targeted DNA sequence. In some embodiments, the composition further comprises at least one site-specific nuclease. Further embodiments of the present disclosure pertain to a method of treating a genetic disorder, or other condition, in a subject in need thereof. | 02-27-2014 |
20130269782 | COMPOSITE ORGANIC-INORGANIC ENERGY HARVESTING DEVICES AND METHODS - A hybrid organic-inorganic thin film is provided. The hybrid organic-inorganic thin film comprising: an organic-phase comprising a porous organic nanostructure comprised of an interpenetrating network having at least one dimension between 0.1 and 100 nm; and an inorganic phase at least partially distributed within the porosity of the organic phase. In a first aspect, the organic phase has a first band gap and the inorganic phase has a second band gap different from the first band gap. A method of producing an organic-inorganic energy harvesting device and a device therefrom comprising the hybrid organic-inorganic thin film is provided. | 10-17-2013 |
20130109012 | DEVICE TO EXPOSE CELLS TO FLUID SHEAR FORCES AND ASSOCIATED SYSTEMS AND METHODS | 05-02-2013 |
20120226187 | Vestibular Implant - A vestibular implant comprising a stimulation unit to generate electric stimuli and deliver to electrode arrays is disclosed. The stimulation unit generates electric stimuli in response to a user input or continuously generates electrical stimuli. The electrode arrays comprise electrodes and are adapted for placement within a semicircular canal of an ear. The electric stimuli is delivered from the stimulation unit to the electrode so that the electrodes apply electric stimuli. A predetermined electric stimulus is applied to restore spontaneous vestibular activity during a Meniere's attack. A continuous, unmodulated electric stimulus is applied to suppress the symptoms of unilateral loss of vestibular function. Additionally, the electrodes record electrically evoked compound action potentials (eCAP). An appropriate location for the placement of the electrode array is determined based on the recorded eCAP. | 09-06-2012 |
20110132439 | FULLERENE COMPOUNDS FOR SOLAR CELLS AND PHOTODETECTORS - Amorphous fullerene derivatives and their use in organic electronic devices that include the fullerene derivative as the electron acceptor component in the device's active layer. | 06-09-2011 |
20110105712 | ZWITTERIONIC POLYMERS HAVING BIOMIMETIC ADHESIVE LINKAGES - Zwitterionic polymers having adhesive groups, methods for making the polymers, surfaces having the polymers grafted thereto and grafted therefrom, and methods for making and using the polymer-modified surfaces. | 05-05-2011 |
20110091149 | POLING STRUCTURES AND METHODS FOR PRODUCING ELECTRO-OPTIC ACTIVITY IN ORGANIC NONLINEAR OPTICAL MATERIALS FOR ELECTRO-OPTIC DEVICES - Poling structures and methods utilizing an electrostatic field generated from a polar dielectric material, including pyroelectric and ferroelectric materials, to produce electro-optic activity in organic nonlinear optical materials. | 04-21-2011 |
20110058652 | SHORT WORKING DISTANCE SPECTROMETER AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS - A spectrometer includes a rigid body having a first planar face with an orientation and a second planar face with a different orientation than the first planar face. The first and second planar faces are configured to position Bragg diffraction elements, and the orientation of the first planar face and the different orientation of the second planar face are arranged to convey a predetermined spectral range of the electromagnetic radiation to non-overlapping regions of the sensor location via the diffraction elements. | 03-10-2011 |