| UNIVERSITY OF VIRGINIA PATENT FOUNDATION Patent applications |
| Patent application number | Title | Published |
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| 20130130965 | METHOD TO DETECT AND TREAT INFECTIOUS OR INFLAMMATORY DIARRHEA BASED ON REG1 - The present invention relates to methods for the diagnosis, treatment and prevention of infectious and/or inflammatory diarrhea. | 05-23-2013 |
| 20130123341 | Methods, compositions and kits for diagnosing and treating Alzheimer's disease using mitochondrial CO3 gene mutations - Methods and kits are provided for diagnosing, prognosing and treating Alzheimer's disease (AD) by identifying heteroplasmic mitochondrial mutations in cytochrome c oxidase subunit 3 (CO3). The methods are efficient, economical, and rapid, for diagnosis, prognosis and subsequent early treatment of AD in subjects. | 05-16-2013 |
| 20130116649 | Method and System For The Safety, Analysis and Supervision of Insulin Pump Action and Other Modes of Insulin Delivery in Diabetes - An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring. | 05-09-2013 |
| 20130116292 | NEURORESTORATION WITH R(+) PRAMIPEXOLE - Formulations and methods of use thereof for restoring neuronal, muscular (cardiac and striated) and/or retinal tissue function in children and adults afflicted with chronic neurodegenerative diseases, such as neurodegenerative movement disorders and ataxias, seizure disorders, motor neuron diseases, and inflammatory demyelinating disorders, are described herein. Examples of disorders include Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). The method involves administering a pharmaceutical composition containing an effective amount of a tetrahydrobenzathiazole, preferably a formulation consisting substantially of the R(+) enantiomer of pramipexole. R(+) pramipexole is generally administered in doses ranging from 0.1-300 mg/kg/daily, preferably 0.5-50 mg/kg/daily, and most preferably 1-10 mg/kg/daily for oral administration. Daily total doses administered orally are typically between 10 mg and 500 mg. Alternatively, R(+) pramipexole can be administered parenterally to humans with acute brain injury in single doses between 10 mg and 100 mg, and/or by continuous intravenous infusions between 10 mg/day and 500 mg/day. | 05-09-2013 |
| 20130102835 | ANISOTROPIC REINFORCEMENT AND RELATED METHOD THEREOF - Anisotropic reinforcements and synthetic materials are provided in which the fibers, mesh, weave, or otherwise interlaced or networked components thereof are oriented in one direction so as to create greater stiffness and/or tension in the one direction of the patch relative to other directions of the reinforcement. Methods of producing such anisotropic reinforcements are provided. The anisotropic reinforcements are advantageously suitable for the surgical repair of incisions, openings, defects, etc. of the cardiovascular system and allow healing to occur while preserving mechanical function, particularly ventricular function. | 04-25-2013 |
| 20130096428 | ACCESS SYSTEM FOR FEMORAL VASCULATURE CATHETERIZATION AND RELATED METHOD - An access system and method for obtaining access to the interior vascular structures or other regions or collections of fluid or fluid-filled cavities inside the body. The system and method provides for injection of contrast agents (to confirm ideal position or condition), the passage of guide wires, and the eventual catheterization of the heart and other parts of the body via the pathway established through the puncture of a femoral artery. The system and method provides the ability to inject a contrast material and pass a guide wire through the same introducer device simultaneously (without necessarily moving it or removing any parts), with the device designed to prevent the backflow of the contrast material through the guide wire port during the contrast injection process The ideal location of access in the vein or artery can be seen by injecting contrast from a needle inside the structure and then using fluoroscopy. | 04-18-2013 |
| 20130094729 | SINGULAR VALUE FILTER FOR IMAGING OR DETECTION - Apparatus or techniques can include obtaining information indicative of energy, such as ultrasonic energy, reflected from a tissue region, forming respective input matrices representative of the obtained information, the input matrices respectively comprising an ensemble-of-interest and at least one ensemble corresponding to a spatial location nearby a spatial location corresponding to the ensemble-of-interest, performing respective singular value decompositions on the respective input matrices to obtain respective sets of singular values corresponding to respective sets of singular vectors, obtaining respective output matrices including weighting a respective projection of a respective ensemble-of-interest onto at least one of the singular vectors included in a respective set of singular vectors, and, using the respective output matrices, at least one of determining a characteristic, or constructing an image, of at least a portion of the tissue region. | 04-18-2013 |
| 20130090556 | Coaxial Catheter Systems for Transference of Medium - A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting an inner tube into the outer tube and aligning them such that port holes on both of the tubes will overlap and permit a flux of the therapeutic agent to flow into the brain in such a way as to minimize the effects of trapped air, virtually eliminate backflow of the agent, and avoid the potential for additional damage to the brain since only one surgical placement of the outer tube is needed. Similarly, the method, technique system may be utilized to remove fluids or other medium from the brain, tissues, and organs to minimize the effects of escaped air or negative pressure. | 04-11-2013 |
| 20130085386 | BLOOD FLOW BYPASS CATHETERS AND METHODS FOR THE DELIVERY OF MEDIUM TO THE VASCULATURE AND BODY DUCTS - A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, continuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion. | 04-04-2013 |
| 20130084565 | VERSATILE, VISIBLE METHOD FOR DETECTING POLYMERIC ANALYTES - The invention provides methods to detect or determine the presence or amount of a polymeric analyte in a sample, which employ magnetic substrates and subjects the sample and the magnetic substrate to forms of energy so as to induce aggregate formation. | 04-04-2013 |
| 20130072428 | Methods and Compounds Regulating the Erythroid Response to Iron Deficiency - The present invention discloses the signaling pathway involved erythroid repression by iron deficiency. Further disclosed is anon-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakaryocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation. | 03-21-2013 |
| 20130064663 | MORPHING SEGMENTED WIND TURBINE AND RELATED METHOD - A downwind morphing rotor that exhibits bending loads that will be reduced by aligning the rotor blades with the composite forces. This reduces the net loads on the blades which therefore allow for a reduced blade mass for a given maximum stress. Also provided is a pre-aligned configuration rotor whereby the rotor geometry and orientation does not change with wind speed, and instead is fixed at a constant downwind deflection consistent with alignment at or near the rated wind speed conditions. Also provided is a twist morphing rotor where the airfoil-shapes around the spars twist relative to the wind due to aerodynamic forces so as to unload the rotors when there is a gust. This can help reduce unsteady stresses on the blade and therefore may allow for reduced blade mass and cost. The twist morphing rotor may be combined with either downwind morphing rotor or pre-alignment rotor. | 03-14-2013 |
| 20130017153 | UNIT DOSAGE OF APADENOSON - The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging. | 01-17-2013 |
| 20130014916 | MULTIFUNCTIONAL THERMAL MANAGEMENT SYSTEM AND RELATED METHOD - A system and related method that provides, but is not limited thereto, a thin structure with unique combination of thermal management and stress supporting properties. An advantage associated with the system and method includes, but is not limited thereto, the concept providing a multifunctional design that it is able to spread, store, and dissipate intense thermal fluxes while also being able to carry very high structural loads. An aspect associated with an approach may include, but is not limited thereto, a large area system for isothermalizing a localized heating source that has many applications. For example it can be used to mitigate the thermal buckling of ship deck plates, landing pad structures, or any other structures subjected to localized heating and compressive forces. It can also be used as a thermal regulation system in numerous applications, including but not limited to under-floor heating for residential or commercial buildings or for the de-icing of roads, runways, tunnels, sidewalks, and bridge surfaces. | 01-17-2013 |
| 20130012559 | MOLECULAR GENETIC APPROACH TO TREATMENT AND DIAGNOSIS OF ALCOHOL AND DRUG DEPENDENCE - Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes. | 01-10-2013 |
| 20130009667 | SUB-THRESHOLD FPGA AND RELATED CIRCUITS AND METHODS THEREOF | 01-10-2013 |
| 20120330184 | Access Needle Pressure Sensor Device and Method of Use - A tool and method of positioning and delivering medical devices and therapeutics within the pericardial space, as well as other body part or space. A needle is inserted into the chest through a sub-xiphoid puncture, and the pressure within the needle is monitored manometrically or otherwise sensed as the needle is advanced towards the pericardial space. By reading the pressure within the needle while it is advanced, the clinician is able to know that he or she is avoiding insertion of it into organs or spaces not intended to be the target location. In addition the retractable sharp edge allows the operator to access the space and cut tissue but do so safely by retracting the sharp edge. | 12-27-2012 |
| 20120321687 | COMPOSITIONS AND METHODS FOR USING AND IDENTIFYING ANTIMICROBIAL AGENTS - The present invention provides proteins with antimicrobial activity, and methods for treating subjects by administering the proteins. In particular, the invention provides methods for treating and/or preventing microbial diseases and infections. The present invention further provides the target for these antimicrobial agents, as well as assays for identifying regulators of the target. | 12-20-2012 |
| 20120310052 | SYSTEMS AND METHODS FOR DETERMINING LOCATION OF AN ACCESS NEEDLE IN A SUBJECT - Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information. | 12-06-2012 |
| 20120302592 | TOPIRAMATE PLUS NALTREXONE FOR THE TREATMENT OF ADDICTIVE DISORDERS - The present invention provides for the use of combinations of drugs to treat addictive disorders. | 11-29-2012 |
| 20120296213 | ULTRASOUND FOR LOCATING ANATOMY OR PROBE GUIDANCE - A hand-held apparatus can be used to assist in guiding a probe or locating a particular anatomical target in a subject. The apparatus can include an ultrasonic transducer located on or within a housing and configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. In an example, the apparatus can include a motion tracking circuit configured to provide information indicative of a motion of the hand-held apparatus to the processor circuit, and a display configured to present information about a location of the target with respect to a portion of the hand-held apparatus, the information about the location determined by the processor circuit using the obtained information indicative of the ultrasonic energy reflected by the target and the information indicative of the motion of the hand-held apparatus. | 11-22-2012 |
| 20120285114 | Manufacture of Lattice Truss Structures from Monolithic Materials - Methods and systems to manufacture lattice-based sandwich structures from monolithic material eliminate the bonding process which is conventionally used to join lattice-based truss cores to facesheets to form sandwich structures. The bonded interface is a key mode of failure for sandwich structures which are subjected to shear or bending loads because the nodes transfer forces from the facesheets to the core members while the topology for a given core relative density dictates the load carrying capacity (assuming adequate node-bond strength exists). In one aspect, a core and related structures provide very low density, good crush resistance and high in-plane shear resistance. Another aspect of the truss structures may include sandwich panel cores and lattice truss topology that may be designed to efficiently support panel bending loads while maintaining an open topology that facilitates multifunctional applications. | 11-15-2012 |
| 20120283582 | SYSTEMS AND METHODS FOR DETERMINING LOCATION OF AN ACCESS NEEDLE IN A SUBJECT - Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information. | 11-08-2012 |
| 20120264804 | T TYPE CALCIUM CHANNEL BLOCKERS AND THE TREATMENT OF DISEASES - The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to the mammal a therapeutically effective amount of a T type calcium channel inhibitor, a prodrug thereof, or a pharmaceutically acceptable salt of said inhibitor or prodrug, wherein the T type calcium channel inhibitor blocks a splice variant of an α1H isoform of T type calcium channels. | 10-18-2012 |
| 20120252031 | COMPOSITIONS AND METHODS FOR REGULATING SAS1R - The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor. Six SAS1R variants, including the full length SAS1R, were identified. mSLLP1 and SAS1R co-localized to oocytes and to acrosomes of acrosome-reacted sperm. Interactions between mSLLP1 and SAS1R were demonstrated by far-western analysis, in a yeast two-hybrid system under stringent selection conditions, and by immunoprecipitation of SAS1R by anti-mSLLP1 as well as the converse. Purified recombinant SAS1R was found to have protease activity, to inhibit fertilization in-vitro, and to induce an immune response in females. Together, the results suggest SAS1R is a proteolytically active, oocyte and early embryo specific oolemmal metalloprotease receptor for the sperm intra-acrosomal ligand SLLP1 and is a target for regulating fertilization and as a contraceptive. | 10-04-2012 |
| 20120245556 | System, Method and Computer Program Product For Adjustment of Insulin Delivery in Diabetes Using Nominal Open-Loop Profiles - A method, system and computer program product for correcting a nominal treatment strategy of a subject with diabetes. The method, system and computer program product may be configured for providing input whereby the input may include: open-loop therapy settings for the subject, data about glycemic state of the subject; and (optionally) data about meals and/or exercise of the subject. The method, system and computer program product may be configured for providing output, whereby the out-put may include an adjustment (correction) to the open-loop therapy settings for the subject for insulin delivery to the subject. | 09-27-2012 |
| 20120244564 | ULTRASOUND-BASED METHOD AND RELATED SYSTEM TO EVALUATE HEMOSTATIC FUNCTION OF WHOLE BLOOD - Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined range of displacement values, wherein the force is increased or decreased depending upon whether the measured displacement is below or above the predetermined range, respectively, and computing a mechanical property value resultant from the displacement of the material | 09-27-2012 |
| 20120235538 | Capillary Force Actuator Device and Related Method of Applications - An actuator capable of generates force by leveraging the changes in capillary pressure and surface tension that result from the application of an electrical potential. The device, which will be referred to as a Capillary Force Actuator (CFA), and related methods, employs a conducting liquid bridge between two (or more) surfaces, at least one of which contains dielectric-covered electrodes, and operates according to the principles of electrowetting on dielectric. | 09-20-2012 |
| 20120229617 | HAND-HELD PORTABLE FUNDUS CAMERA FOR SCREENING PHOTOGRAPHY - System and Method pertaining to the modification and integration of an existing consumer digital camera, for example, with an optical imaging module to enable point and shoot fundus photography of the eye. The auto-focus macro capability of existing consumer cameras is adapted to photograph the retina over an extended diopter range, eliminating the need for manual diopter focus adjustment. The thru-the-lens (TTL) auto-exposure flash capability of existing consumer cameras is adapted to photograph the retina with automatic flash exposure eliminating the need for manual flash adjustment. The consumer camera imaging sensor and flash are modified to allow the camera sensor to perform both non-mydriatic focusing of the retina using infrared illumination and standard color flash photography of the retina without the need for additional imaging sensors or mechanical filters. These modifications and integration of existing consumer cameras for fundus photography of the eye significantly improve ease of manufacture and usability over existing fundus cameras. | 09-13-2012 |
| 20120222747 | PASSIVE COMPONENTS FOR MICRO-FLUIDIC FLOW PROFILE SHAPING AND RELATED METHOD THEREOF - The present invention relates to microfluidic systems and methods for controlling the flow of fluid using passive components engineered into the microchannels. These passive flow components include fluidic diodes, fluidic capacitors, and fluidic inductors. Various fluidic circuits are provided to control fluid flow including fluid rectifiers, fluid band pass filters, and fluid timers. | 09-06-2012 |
| 20120219499 | COMPOSITIONS AND METHODS FOR DETECTING PLECTIN-1 AS A BIOMARKER FOR CANCER - The present invention provides compositions and methods useful for diagnostic and imaging techniques for detecting and localizing the biomarker Plectin-1. The present invention provides multimeric peptide ligand complexes for targeting Plectin-1, such as the multimeric peptide ligand complex having the formula (βAKTLLPTPGGS(PEG5000))4 KKKKDOTAβA-NH | 08-30-2012 |
| 20120214858 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS - Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors. | 08-23-2012 |
| 20120213837 | COMPOSITIONS AND METHODS FOR BIOACTIVE COATINGS TO IMPROVE ALLOGRAFT INCORPORATION - The invention provides compositions and methods useful for treating wounds and enhancing wound healing. The present invention discloses a continuous polymer coating system to provide sustained localized delivery of bioactive agents. The data demonstrate the efficacy of a bioactive coating comprising the polymer PLAGA and the agent FTY720, a selective agonist for sphingosine 1-phosphate receptors, and biologically active derivatives and analogs thereof, for use in wound healing. In vitro drug release studies validated 64% loading efficiency with complete release of compound following 14 days. Mechanical evaluation of healing bone showed significant enhancement of mechanical stability in FTY720 treatment groups. Superior osseous integration across the host-graft interface, significant enhancement in smooth muscle cell investment, and reduction in leukocyte recruitment were evident in FTY720 treated groups. The present invention is useful for enhancing angiogenesis for wound healing. | 08-23-2012 |
| 20120202800 | DUAL SMALL MOLECULE INHIBITORS OF CANCER AND ANGIOGENESIS - The present invention provides analogs and derivatives of thalidomide which inhibit cancer and angiogenesis. The present invention further provides compounds which disrupt microtubule polymerization. The present further provides methods of treating cancers comprising mutant p53. | 08-09-2012 |
| 20120199421 | Gas-Expanded Lubricants for Increased Energy Efficiency and Related Method and System - Method and System of lubricating at least one moving part with a medium. The medium includes a dissolved mixture of lubricant and compressed gas. The amount of lubricant and compressed gas may be controlled in forming the dissolved mixture in response to input conditions. A user and/or external factors may be used to determine the input conditions. In response to the input conditions the amount of lubricant and compressed gas is delivered to the moving part that is housed in a pressurized chamber. The properties of the dissolved mixture can be adjusted, whereby the properties may include, but are not limited to, the following: viscosity, temperature, and thermal conductivity. This adjustment to the gas may be accomplished, for example, by releasing gas from the pressurized chamber in an amount to adjust the properties. In a further approach, lubricant may be scavenged from the pressurized chamber by returning surplus lubricant to its original source or other designated location. | 08-09-2012 |
| 20120191361 | Tracking the Probability for Imminent Hypoglycemia in Diabetes From Self-Monitoring Blood Glucose (SMBG) Data - A method, system and related computer program product for tracking the probability of hypoglycemia from routine self-monitoring of blood glucose (SMBG) data in patients with diabetes. A specific bivariate probability distribution of low BG events based jointly on the Low BG Index (LBGI) and the Average Daily Risk Range (ADRR) is used to predict hypoglycemia probability of occurrence from inputted SMBG data. The SMBG data is retrieved from a series of SMBG data of a patient available from the patient's glucose meter and allows tracking of the probability for future hypoglycemia over a predetermined duration, e.g., a | 07-26-2012 |
| 20120184042 | Electron Transfer Dissociation for Biopolymer Sequence Analysis - The present invention relates to a new method for fragmenting ions in a mass spectrometer through the use of electron transfer dissociation, and for performing sequence analysis of peptides and proteins by mass spectrometry. In the case of peptides, the invention promotes fragmentation along the peptide backbone and makes it possible to deduce the amino acid sequence of the sample, including modified amino acid residues, through the use of an RF field device. | 07-19-2012 |
| 20120183510 | HIGH-THROUGHPUT CULTURE AND TRANSFER DEVICE AND METHOD - A method and device for creating hanging drop cell aggregates. The method and device includes a plurality of pegs that allow for high throughput culture of aggregates. Also disclosed are means of transferring formed aggregates to various destinations, such as well plates, scaffolding, tissues, or wounds. Use of the device permits aggregates to be prepared or created in larger quantities than current methods, and allows for them to be transferred more efficiently. | 07-19-2012 |
| 20120178635 | COMPOSITIONS AND METHODS FOR IDENTIFYING AND DETECTING SITES OF TRANSLOCATION AND DNA FUSION JUNCTIONS - The present invention provides a powerful technique based on ultra high-throughput sequencing that finds structural aberrations of chromosomes and defines breakpoints. It is disclosed herein that, Anchored ChromPET, a technique to capture and interrogate targeted sequences in the genome, is a cost-effective means to identify chromosomal aberrations and define breakpoints. Using this method, we defined the BCR-ABL1 translocation DNA breakpoint to a base-pair resolution in Philadelphia chromosome positive cell lines and patient cells. This DNA-based method is highly sensitive and can detect signal using samples from which it is hard to obtain RNA or cells where the RNA expression has been silenced. These data demonstrate that ChromPET is a cost-effective and powerful technology that can identify and follow the appearance of chromosomal aberrations in various organisms, including, but not limited to, humans. | 07-12-2012 |
| 20120177669 | PHOSPHOPEPTIDES AS MELANOMA VACCINES - We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived from source proteins which may have roles in cancer development, growth and metastasis. Most were expressed exclusively by either melanomas or transformed B cells, suggesting the potential to define cell type-specific phosphatome “fingerprints”. We generated HLA-DRβ1*0101-restricted CD4 | 07-12-2012 |
| 20120173200 | Method, System and Computer Program Product for Real-Time Detection of Sensitivity Decline in Analyte Sensors - Method, system and computer program product for providing real time detection of analyte sensor sensitivity decline is continuous glucose monitoring systems are provided. | 07-05-2012 |
| 20120165993 | Self-Programming Thermostat System, Method and Computer Program Product - Self-programmable thermostat control system and method that automatically senses, creates and suggests highly energy efficient optimized setback schedules in a controllable and predictable manner for a user in accordance with consistently updated historical occupancy patterns of a heated and/or cooled space. Through the use of this system and method, users will be able to reduce inefficiency from the setback schedules produced by other thermostats and select one of the many energy efficient setback schedules produced by the system through an easy to use display screen built into the self-programmable thermostat. With this unique system and method, the user is able to customize their energy efficiency and comfort level in their cooled and/or heated space by selecting the set-back schedule that fits best with their pocketbook and comfort level all at the turn of a knob. | 06-28-2012 |
| 20120163691 | TIME-DOMAIN ESTIMATOR FOR IMAGE RECONSTRUCTION - One or more systems, methods, or computer program products can include receiving an echo data set including information representative of an echo sensed by a transducer, provided at least in part by one or more actual targets included in a region of interest. The region of interest can be modeled, including selecting or generating an array manifold matrix including information corresponding to any one or more candidate targets. The weights of the candidate targets can be determined using the array manifold matrix and the echo data set, including minimizing an argument of a function modeling the weights of the candidate targets. In an example, the echo data set can be dithered, such as by adding a specified dithering signal. | 06-28-2012 |
| 20120160166 | Reliant Thermal Barrier Coating System and Related Apparatus and Methods of Making the Same - A method and apparatus for forming a thermal barrier coating system in communication with at least a portion of at least one substrate. The method includes: depositing a first bond coat on at least a portion of at least one substrate; depositing a first thermal barrier coat disposed on the bond coat; whereby the deposition occurs in one or more chambers to form the thermal barrier coating system; and wherein the deposition of the first bond coat (or subsequent bond coats) and the deposition of the first thermal barrier coat (or subsequent thermal barrier coats) is performed without out-of chamber handling of the thermal barrier coating system. | 06-28-2012 |
| 20120156792 | REAGENTS FOR ELECTRON TRANSFER DISSOCIATION IN MASS SPECTROMETRY ANALYSIS - The invention provides improvements in reagents for use in electron transfer dissociation ionization techniques for use in mass spectrometry, particularly for sequencing peptides and proteins using mass spectrometric techniques involving electro-spray ionization and MS/MS characterization of fragment ions. The novel reagents used in the inventive methods allow for more effective determination of protein sequences, especially of long peptides or post-translationally modified protein fragments. Use of the polycyclic aromatic hydrocarbons azulene, homoazulene, and acenaphthylene, and homodimers and heterodimers thereof, are described. | 06-21-2012 |
| 20120149587 | METHOD FOR DETECTING NUCLEATED CELLS - The invention provides methods to detect or quantify cells such as nucleated cells in a sample such as a physiological sample, which employ magnetic substrates and subjects the sample and the magnetic substrate to forms of energy so as to induce aggregate formation. | 06-14-2012 |
| 20120142590 | Methods and Compounds Regulating the Erythroid Response to Iron Deficiency - The present invention discloses the signaling pathway involved in erythroid repression by iron deficiency. Further disclosed is a non-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakaryocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation. | 06-07-2012 |
| 20120137974 | Method and Apparatus For Application of Metallic Alloy Coatings - A directed vapor deposition (DVD) method and system for applying at least one bond coating on at least one substrate for thermal barrier coating systems. To overcome the limitations incurred by conventional methods, the DVD system uses an electron beam directed vapor deposition (DVD) technique to evaporate and deposit compositionally and morphologically controlled bond coats at high rate. The present DVD system uses the combination of an electron beam and a combined inert gas/reactive gas carrier jet of controlled composition to create engineering films. In this system, the vaporized material can be entrained in the carrier gas jet and deposited onto the substrate at a high rate and with high materials utilization efficiency. The velocity and flux of the gas atoms entering the chamber, the nozzle parameters, and the operating chamber pressure can all be significantly varied, facilitating wide processing condition variation and allowing for improved control over the properties of the deposited layer. | 06-07-2012 |
| 20120130698 | System, Method and Computer Simulation Environment For In Silico Trials in Pre-Diabetes and Type 2 Diabetes - An electronic system is provided that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, wherein the system includes a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, including an electronic module that models endogenous glucose production (EGP(t)), or meal glucose rate of appearance (Ra(t>>, or glucose utilization (U(t)), or renal excretion of glucose (B(t)), a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, including an electronic module that models insulin secretion (S(t)), an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters, and a processing module that calculates an effect of variation of at least one metabolic parameter value on the glucose insulin metabolic system of a virtual subject by inputting the plurality of metabolic parameter values. | 05-24-2012 |
| 20120123461 | ACCESS TROCAR AND RELATED METHOD THEREOF - System and method that is directed to medical treatments of organs having anatomical spaces, such as (but not limited to) the heart and the pericardial space. Specifically, an apparatus and method is provided for safely accessing anatomical spaces with surfaces to deliver medical devices or media into such spaces, or to remove fluids from such spaces. The methods and apparatus may include a first elongated member with a sharp tip used to penetrate the surface surrounding the anatomical space with a second elongated member with a helical tine used to engage the surface and lift the surface away from the underlying anatomical space. Once the first elongated member has incised the surface, it is removed, and the incision may be used as a point of entry for delivering media or medical devices into the anatomical space, or for carrying out further medical procedures. | 05-17-2012 |
| 20120115149 | SEROTONIN TRANSPORTER GENE AND TREATMENT OF ALCOHOLISM - The gene (SLC6A4) responsible for encoding the serotonin transporter (SERT) has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on diagnosing variations in the polymorphisms of the SERT gene and expression and activity of the SERT gene, as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders, for monitoring treatment and/or abuse (addictive behavior), and for determining which treatment should be used. | 05-10-2012 |
| 20120108463 | COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DETERGENT STABILITY SCREEN - The invention provides methods to assess protein stability and to obtain sizing information. In one aspect, the screen comprises a 94 detergent panel and a series of MWCO filtered microplates. A protein of interest is bound to an affinity matrix and aliquoted into a 96-well microplate. Wells containing the immobilized protein are washed in the new detergent and then eluted in the new detergent into a collection plate. Protein not stable in the new detergent is precipitated on the resin and not present in the elutions. Half of the elution is passed through a high (i.e., 300 kDa) MWCO microplate and the other half through a low (i.e., 100 kDa) MWCO microplate. Elutions from the microplates are spotted on a nitrocellulose membrane, visualized by Western analysis (or by some other method), and quantified. The high MWCO provides stability readout and the ratio of low/high kDa provides sizing information. | 05-03-2012 |
| 20120094305 | Methods For Treating And Diagnosing Fibrotic And Fibroproliferative Diseases - The present invention provides compositions and methods for diagnosing and treating fibrotic lung disease. In one embodiment the diagnostic method comprises determining the amount of circulating CXCL-12 in a patient relative to a control. | 04-19-2012 |
| 20120078067 | System Coordinator and Modular Architecture for Open-Loop and Closed-Loop Control of Diabetes - A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention. | 03-29-2012 |
| 20120065104 | COMPOSITIONS AND METHODS FOR A MEMBRANE PROTEIN CRYSTALLIZATION SCREENING KIT - The present invention comprises compositions and methods useful as a system for efficiently determining conditions that result in the formation of crystals of membrane proteins from solutions containing a membrane protein in a purified and soluble state. The system is comprised of two primary components, a solubility screen and a crystallization screen. Each component is a set of solutions. The present invention further provides a kit comprising solutions of the invention and an instructional material for the use thereof. | 03-15-2012 |
| 20120059353 | CGM-Based Prevention of Hypoglycemia Via Hypoglycemia Risk Assessment and Smooth Reduction of Insulin Delivery - An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually. | 03-08-2012 |
| 20120059003 | INHIBITORS OF INV(16) LEUKEMIA - This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in ˜12% of acute myeloid leukemia (AML). The inv(16) fusion results in expression of the CBFβ-SMMHC fusion protein in the blood cells of afflicted patients. The present invention provides compounds which inhibit the function of both CBFβ and the CBFβ-SMMHC fusion. These compounds block the growth of an inv(16) leukemia cell line as well as increase its apoptosis, while showing minimal effects against non inv(16) cell lines. As a mechanism to develop inhibitors with selectivity for the CBFβ-SMMHC fusion protein, the present invention further provides dimeric derivatives of these compounds which show both increased potency as well selectivity for CBFβ-SMMHC. These compounds show potent inhibition of an inv(16) leukemia cell line with minimal effects on non inv(16) cell lines. Analysis of the pharmacokinetics of the developed compounds has made it possible to improve the lifetime of the compound in the plasma of mice to a level commensurate with long-term treatment. | 03-08-2012 |
| 20120056116 | ELECTROSTATIC ACTUATION FOR MANAGEMENT OF FLOW IN MICRO-TOTAL ANALYSIS SYSTEMS (u-TAS) AND RELATED METHOD THEREOF - In an example, an apparatus, such as a microfluidic assembly, can include or can include using a channel including a valve seat, a valve film configured to adjust position with respect to the valve seat, and a first electrode configured to actuate the valve film electrostatically to adjust the position of the valve film to control a flow of a fluid in the channel laterally across the valve seat, the flow in a direction substantially parallel to the film. | 03-08-2012 |
| 20120029266 | ANISOTROPIC REINFORCEMENT AND RELATED METHOD THEREOF - Anisotropic reinforcements and synthetic materials are provided in which the fibers, mesh, weave, or otherwise interlaced or networked components thereof are oriented in one direction so as to create greater stiffness in the one direction of the patch relative to other directions of the reinforcement. Methods of producing such anisotropic reinforcements are provided. The anisotropic reinforcements are advantageously suitable for the surgical repair of incisions, openings, defects, etc. of the cardiovascular system and allow healing to occur while preserving mechanical function, particularly ventricular function. | 02-02-2012 |
| 20120021439 | SERIAL MULTIPLE ANTIGEN COLOCALIZATION IN PARAFFIN-EMBEDDED TISSUE - The present invention provides a novel method called Sequential IMmunoPeroxidase Labeling and Erasing (SIMPLE) that enables the simultaneous visualization of at least five markers within a single tissue section. Utilizing the alcohol-soluble peroxidase substrate 3-amino-9-ethylcarbazole (AEC), combined with a rapid non-destructive method for antibody-antigen dissociation, the present application discloses the ability to erase the results of a single immunohistochemical stain while preserving tissue antigenicity for repeated rounds of labeling. The present invention also provides methods for visualizing multiple antigens simultaneously. | 01-26-2012 |
| 20120010187 | BROAD SPECTRUM BENZOTHIOPHENE-NITROTHIAZOLIDE AND OTHER ANTIMICROBIALS - The invention provides FIG. | 01-12-2012 |
| 20120006335 | Hip Continuous Passive Motion Device and Related Methods - A system for providing continuous passive motion of a subject's leg through hip extension and flexion. The system may have an actuator, a leg support member, a retention surface, and a base. The leg support member may be a support frame with a proximal member and a distal member. The subject places his/her leg on the leg support and the actuator provides a moment of force to the subject's leg to move the leg through the desired range of motion. The system may be controlled allowing the device to operate at different speeds and for different ranges of motion. | 01-12-2012 |
| 20120004512 | Method, System, and Computer Program Product For The Evaluation of Glycemic Control in Diabetes From Self-Monitoring Data - A method, system, and computer program product related to the diagnosis of diabetes, and is directed to predicting the long-term risk of hyperglycemia, and the long-term and short-term risks of severe hypoglycemia in diabetics, based on blood glucose readings collected by a self-monitoring blood glucose device. The method, system, and computer program product pertain directly to the enhancement of existing home blood glucose monitoring devices, by introducing an intelligent data interpretation component capable of predicting both HbA | 01-05-2012 |
| 20110318498 | Coaxial Hollow Cathode Plasma Assisted Directed Vapor Deposition and Related Method Thereof - A plasma generation process that is more optimized for vapor deposition processes in general, and particularly for directed vapor deposition processing. The features of such an approach enables a robust and reliable coaxial plasma capability in which the plasma jet is coaxial with the vapor plume, rather than the orthogonal configuration creating the previous disadvantages. In this way, the previous deformation of the vapor gas jet by the work gas stream of the hollow cathode pipe can be avoided and the carrier gas consumption needed for shaping the vapor plume can be significantly decreased. | 12-29-2011 |
| 20110301210 | USE OF PRAMIPEXOLE TO TREAT AMYOTROPHIC LATERAL SCLEROSIS - The present invention is directed to compositions comprising pramipexole and the use of such compositions to treat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). As shown in FIG. | 12-08-2011 |
| 20110292054 | System and Method for Low Bandwidth Image Transmission - An image transmission method (and related system) for obtaining data of a local subject and processing the data of the local subject to fit a local model of at least a region of the local subject and extract parameters of the local model to capture features of the region of the local subject. The method (and related system) may also include obtaining data of at least one remote subject and processing the data of the remote subject to fit at least one of at least one region of the remote subject and extract parameters the remote model to capture features of the region of the remote subject. The method (and related system) may also include transmitting the extracted parameters of the local region to a remote processor and reconstructing the local image based on the extracted parameters of the local region and the extracted parameters of the remote region. | 12-01-2011 |
| 20110283873 | Hybrid Periodic Cellular Material Structures, Systems, and Methods For Blast and Ballistic Protection - Structures based upon periodic cellular materials that provide a potential for defeating combinations of both air blast loading and ballistic attack either sequentially or simultaneously, or combination of both. The cellular structures may also be configured to meet the stiffness and strength support requirements of particular vehicle or other applications, systems or structures. The armor is therefore potentially able to support normal service loads and defeat blast and ballistic threats when necessary. The structure provides for using efficient load support capabilities of the material (without a high armor protection level) in low threat conditions, as well as the ability to modify the system to increase its level protection to a desired or required level. This would reduce the weight of the protection system in normal (low threat) conditions which reduces vehicle wear and tear, as well as cost savings in fabrication of applicable structures or systems. | 11-24-2011 |
| 20110264378 | Method, System, and Computer Program Product For Tracking of Blood Glucose Variability in Diabetes - An embodiment may be in the field of glycemic analysis and control. More specifically, an embodiment or approach may provide a novel method, system, and computer program for the visual and quantitative tracking of blood glucose variability in diabetes from self-monitoring blood glucose (SMBG) data and/or continuous glucose monitoring (CGM) data. More particularly, an embodiment or aspects thereof may use glucose measurements obtained from self-monitoring data and/or CGM data of an individual or a group of individuals to track and analyze blood glucose variability. | 10-27-2011 |
| 20110264374 | Method, Computer Program Product and System for Individual Assessment of Alcohol Sensitivity - Methods/computer methods and systems/computer systems for the evaluation of two idiosyncratic indices of alcohol intoxication: the Alcohol Sensitivity Index (ASI), and the brain-specific Cognitive Alcohol Sensitivity Index (CASI). The two indices are based on the new Metabolic and Cognitive Minimal Models of Alcohol Dynamics, and are derived from specific clinical protocols, accompanied by specific data analysis procedures. The two indices may be derived from specific clinical and cognitive assessment protocols, accompanied by specific data analysis procedures based on the new metabolic and cognitive minimal models of alcohol dynamics. | 10-27-2011 |
| 20110264010 | Systems, Devices, and Methods for Interpreting Movement - According to some exemplary embodiments, a method or system can involve associating a plurality of biokinetographic comparison results with a first specific dysfunction from a group of specific dysfunctions, each of the biokinetographic comparison results obtained from a comparison of a biokinetographic value to a standard for a corresponding biokinetographic variable. | 10-27-2011 |
| 20110250385 | Multifunctional Periodic Cellular Solids and the Method of Making the Same - Methods of making truss-based periodic cellular solids that have improved structural properties and multifunctional design. Many materials (metals, ceramics, glasses, polymers, composites and even semiconductors) can be shaped into cellular, truss-like architectures with open, closed or mixed types of porosity and then very uniformly arranged in controlled, three-dimensional space-filling arrays. The truss-like elements do not necessarily have a constant cross-section, nor are they necessarily straight or solid throughout (they could be hollow). Their cross sections can be circular, square, triangular, I-beam or other shapes of interest depending on multifunctional needs. When bonded together by solid state, liquid phase, pressing or other methods at points of contact, a cellular structure of highly repeatable cell geometry and few imperfections results. The bonds hold the truss elements together in a desired configuration, allow load to be efficiently transferred amongst them and make the resulting structure significantly more rigid when bent, compressed or sheared. These constructed cellular solids offer a broad range of multifunctional structural uses with a tremendous freedom for choosing the truss type, orientation and distribution. Multiple materials can be intermixed. | 10-13-2011 |
| 20110236974 | COMPOSITIONS AND METHODS FOR MAKING AND USING LAMININ NANOFIBERS - The present invention provides methodologies and parameters for fabrication of the hybrid biomaterial by blending pure laminin or complex extracts of tissues containing laminin with biopolymers such as polycaprolactone (PCL), polylactic/polyglycolic acid copolymer (PLGA) or Polydioxanone (PDO) in fluoroalcohols (HFP, TFA), fabrication of substrates and scaffolds and devices from the hybrid biomaterial in forms such as films, nanofibers by electrospinning or microspheres, and the biological or biomedical use of the material or devices derived from it. | 09-29-2011 |
| 20110230730 | Method, System and Computer Program Product for Limb Movement Analysis for Diagnosis of Convulsions - A method or system is provided for diagnosing convulsions of a subject. The method or system may include two general components. First, a device or apparatus that measures and accumulates an electronic data stream representing the physical movements of the human limb(s) and presents that data to a suitable computational device or system for further processing. Second, a set of software or firmware algorithms that operates within the computational device on the data stream for the purpose of describing and characterizing the statistical properties of the movement signal during clinical seizure episodes. The system comprised of both components serves to distinguish and diagnose the movement features of ES events from those of PNES. | 09-22-2011 |
| 20110223103 | Multimodal Imaging of Atherosclerotic Plaque Targeted to LOX-1 - The present invention provides multiple modalities for detecting LOX-1. More particularly, an imaging composition is provided that allows for the in vivo imaging of atherosclerotic plaque. | 09-15-2011 |
| 20110218222 | NEURORESTORATION WITH R(+) PRAMIPEXOLE - Formulations and methods of use thereof for restoring neuronal, muscular (cardiac and striated) and/or retinal tissue function in children and adults afflicted with chronic neurodegenerative diseases, such as neurodegenerative movement disorders and ataxias, seizure disorders, motor neuron diseases, and inflammatory demyelinating disorders, are described herein. Examples of disorders include Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). The method involves administering a pharmaceutical composition containing an effective amount of a tetrahydrobenzathiazole, preferably a formulation consisting substantially of the R(+) enantiomer of pramipexole. R(+) pramipexole is generally administered in doses ranging from 0.1-300 mg/kg/daily, preferably 0.5-50 mg/kg/daily, and most preferably 1-10 mg/kg/daily for oral administration. Daily total doses administered orally are typically between 10 mg and 500 mg. Alternatively, R(+) pramipexole can be administered parenterally to humans with acute brain injury in single doses between 10 mg and 100 mg, and/or by continuous intravenous infusions between 10 mg/day and 500 mg/day. | 09-08-2011 |
| 20110196497 | Method and System For Fusing a Spinal Region - A method and system for fusing a region in the spine involve the use of at least one guide tube to pass instruments and substances into the spinal region in a minimally invasive manner. In the preferred practice of the method, a guide tube is anchored to a vertebra and the guide tube is moved to thereby position the vertebra. A steerable drilling tool is passed through the guide tube and steered into position to abrade at least a portion of an intervertebral disc and thereby create a cavity in the disc. A flowable substance is passed into the cavity and permitted to solidify to establish fusion in the cavity. Optionally, an uninflated balloon is inserted into the cavity and the balloon is filled with the flowable substance to contain the flowable substance. | 08-11-2011 |
| 20110195936 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 08-11-2011 |
| 20110189169 | COMBINATION OF HGF INHIBITOR AND PTEN AGONIST TO TREAT CANCER - The present invention is directed toward a method of treating cancer by administering to a patient an inhibitor of Hepatocyte Growth Factor and an agonist of PTEN. | 08-04-2011 |
| 20110177000 | Use of S-Nitrosothiol Signaling to Treat Disordered Control of Breathing - The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnormalities. Specifically the invention is directed to treating disordered control of breathing by administering an S-nitrosylating agent selected from the group consisting of ethylnitrite, glutathione, nitric oxide, S-nitrosocysteine, S-nitrosoglutathione, S-nitroso-L-cysteinyl glycine, N-acetyl cysteine and S-nitroso-N-acetyl cysteine. As shown in FIG. | 07-21-2011 |
| 20110152301 | Compounds that Inhibit HIV Particle Formation - The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and compounds for inhibiting HIV particle formation and or treating patients infected with HIV. | 06-23-2011 |
| 20110137703 | METHOD AND SYSTEM FOR DYNAMIC PROBABILISTIC RISK ASSESSMENT - The DEFT methodology, system and computer readable medium extends the applicability of the PRA (Probabilistic Risk Assessment) methodology to computer-based systems, by allowing DFT (Dynamic Fault Tree) nodes as pivot nodes in the Event Tree (ET) model. DEFT includes a mathematical model and solution algorithm, supports all common PRA analysis functions and cutsets. Additional capabilities enabled by the DFT include modularization, phased mission analysis, sequence dependencies, and imperfect coverage. | 06-09-2011 |
| 20110136755 | 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY - The invention provides compounds having the following general formula (I): | 06-09-2011 |
| 20110112443 | Systems, Devices, and Methods for Interpreting Movement - According to some exemplary embodiments, a method or system can involve associating a plurality of biokinetographic comparison results with a first specific dysfunction from a group of specific dysfunctions, each of the biokinetographic comparison results obtained from a comparison of a biokinetographic value to a standard for a corresponding biokinetographic variable. | 05-12-2011 |
| 20110112159 | SEROTONIN TRANSPORTER GENE AND TREAMENT OF ALCOHOLISM - The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs 1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders. | 05-12-2011 |
| 20110107904 | Synergistically-Layered Armor Systems and Methods for Producing Layers Thereof - The armor system according to the present invention also exploits synergistic multi-layering to provide different properties as a function of depth within a sandwich panel. Various embodiments of the invention include a combination of composite sandwich topology concepts with hard, strong materials to provide structures that (i) efficiently support static and fatigue loads, (ii) mitigate the blast pressure transmitted to a system that they protect, (iii) provides very effective resistance to projectile penetration, and (iv) minimizes shock (stress wave) propagation within the multi-layered armor sandwich structure. By using small pieces of highly constrained ceramic, the concept has significant multi-hit potential. | 05-12-2011 |
| 20110076377 | ETHOID COMPOUNDS FOR USE AS FOOD ADDITIVES - Provided herein are food products, ingredients, beverages, and the like, comprising a peptide analog that contains one or more ethoid bonds, along with methods for preparing such peptide analogs, related compositions, and the ethoid peptide analogs themselves. The ethoid compounds described are useful as food ingredients, such as sweeteners, flavor enhancers and taste-modifying agents. | 03-31-2011 |
| 20110070660 | DETECTION OF POLYMERIC ANALYTES - The present invention relates to methods for detecting polymeric analytes, especially biopolymers, and sensors for detecting the polymeric analytes. The present invention uses magnetic beads in a rotating magnetic field to provide a visual detection of the presence of a polymeric analyte, such as nucleic acids, lipids, polysaccharides, proteins, etc. When a polymeric analyte binds to the magnetic beads, application of a rotating magnetic field to the beads results in unique pinwheel formations. Without the presence of the polymeric analyte, the movement of the magnetic beads induced by the rotating magnetic field differs significantly from the pinwheel formations. The pinwheel, therefore, is used to detect the presence of polymeric analytes. | 03-24-2011 |
| 20110065690 | COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA - The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions. | 03-17-2011 |
| 20110065628 | Medication Combinations for the Treatment of Alcoholism and Drug Addiction - The present invention provides for the use of combinations of drugs to treat addictive disorders. More specifically, the present invention provides compositions and methods for treating disorders using combinations of drugs such as topiramate, ondansetron, and naltrexone. | 03-17-2011 |
| 20110065189 | Lacritin-Syndecan Interactions - The present invention relates to methods and compositions useful for the regulation of lacritin, syndecan, and lacritin-syndecan interactions and the signaling pathway downstream of lacritin-syndecan interactions. The invention also relates to regulating lacritin-syndecan interaction to regulate ocular cell survival in response to an insult or injury, in protecting against ocular inflammation, and in promoting ocular wound repair. | 03-17-2011 |
| 20110059182 | SPRAYING DEVICE AND RELATED METHOD FOR CELL AGGREGATES AND CELL AGGREGATE SUSPENSION THEREOF - A sprayer device and related method that delivers multicellular aggregates in suspension. A purpose of the sprayer embodiment may be to deliver cells into chronic wound beds, and additional purposes of the sprayer include additional application in other cell delivery environments, such as during open-heart surgery or other surgeries where it may be desirable to treat internal organs with aggregates of stem cells. | 03-10-2011 |
| 20110047618 | Method, System, and Computer Program Product for Malware Detection, Analysis, and Response - A method, system, and computer program product for detecting malware from outside the host operating system using a disk, virtual machine, or combination of the two. The method, system, and computer program product detects malware at the disk level while computer files in the host operating system are in actual program execution by identifying characteristic malware properties and behaviors associated with the disk requests made. The malware properties and behaviors are identified by using rules that can reliably detect file-infecting viruses. The method, system, and computer program product also uses the disk processor to provide accelerated scanning of virus signatures, which substantially decreases overhead incurred on the host operating system by existing malware detection techniques. In the event that malware is detected, the method, system, and computer program product can respond by limiting the negative effects caused by the malware and help the system recover to its normal state. | 02-24-2011 |
| 20110042512 | Method and Apparatus for Jet Blast Deflection - Methods and apparatuses for passive jet blast deflection or the like. Use of the passive jet blast deflector permits the efficient dispersal of a fast moving local heat source into the environment through passive means while providing a high strength structure. The jet blast deflector system may include a first plate, a second plate, and a cellular core disposed between them adapted to allow cooling ambient air to flow through the cellular core, wherein the first plate, second plate, and core are all seamlessly coupled heat pipes that form a single vapor core to facilitate the spreading and even storing of thermal energy. An ejector plate may be attached to the top of the second plate to create a low pressure zone as the heat source passes over it, thereby pulling the ambient air through the cellular core, facilitating the removal the thermal energy from the system. | 02-24-2011 |
| 20110035601 | System, method and computer program product for protecting software via continuous anti-tampering and obfuscation transforms - Method, system and computer program product for applying existing anti-tampering and obfuscation technique to virtual machine technology and offers several distinct advantages. The anti-tampering and obfuscation transforms can be applied continuously to prevent adversaries from gaining information about the program through emulation or dynamic analysis. In addition, the encryption can be used to prevent hackers from gaining information using static attacks. The use of a virtual machine also allows for low overhead execution of the obfuscated binaries as well as finer adjustment of the amount of overhead that can be tolerated. In addition, more protection can be applied to specific portions of the application that can tolerate slowdown. The incorporation of a virtual machine also makes it easy to extend the technology to integrate new developments and resistance mechanisms, leading to less development time, increased savings, and quicker deployment. | 02-10-2011 |
| 20100327382 | High Bandwidth, Monolithic Traveling Wave Photodiode Array - The monolithic application of a high speed TWPDA with impedance matching. Use of the high speed monolithic TWPDA will allow for more efficient transfer of optical signals within analog circuits and over distances. | 12-30-2010 |
| 20100324436 | System, Method and Computer Program Product for Detection of Changes in Health Status and Risk of Imminent Illness - A method for analysis of cardiac rhythms and the clinical status of a patient, based on calculations of entropy and moments of time series intervals. An optimal determination is made of segments of data that demonstrate statistical homogeneity, specifically with regard to moments and entropy. The invention also involves calculating moments and entropy on each interval segments with the goal of diagnosis of cardiac rhythm. More specifically, an absolute entropy measurement is calculated, providing dynamic information of fundamental importance in diagnosis and analysis. | 12-23-2010 |
| 20100297158 | ANTICANCER VACCINE AND DIAGNOSTIC METHODS AND REAGENTS - The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the patient. The invention further provides a method of identifying tumor antigens. | 11-25-2010 |
| 20100280358 | SINGLE BREATH-HOLD SYSTEM AND METHOD FOR DETECTION AND ASSESSMENT OF MULTI-ORGAN PHYSIOLOGIC, MORPHOLOGIC AND STRUCTURAL CHANGES - In a single breath-hold the physiologic, morphologic and structural changes in multiple organs are detected and assessed. The main steps process include: polarizing the Xe-129 gas; inhalation or introduction of a certain pre-calculated amount of the gas and start of the breath-hold; acquisition of multiple spatially oriented spectrums, localized in the same plane (2D), in multiple different planes (3D) or in 3D plus at multiple time intervals (4D); stop the breath-hold; post-processing of the acquired data; evaluation of the multiple spectrums by comparison of the values in a region of interest with those in surrounding tissues or known as normal. | 11-04-2010 |
| 20100268086 | Intuitive Ultrasonic Imaging System and Related Method Thereof - A hand held ultrasonic instrument ( | 10-21-2010 |
| 20100262117 | PREDICTIVE CONTROL BASED SYSTEM AND METHOD FOR CONTROL OF INSULIN DELIVERY IN DIABETES USING GLUCOSE SENSING - A system and method for providing optimal insulin injections to a subject, using a controller, a continuous glucose monitor, and an insulin delivery unit is disclosed. The controller possesses a discrete-time, linear model predictive control law, means for sending information to the insulin delivery unit, and means for receiving information from the CGM. The control law implemented is derived from a discrete-time model of glucose insulin dynamics and an aggressiveness parameter. The result is that using only glucose measurements obtained from sensor readings and, prior values of external insulin infusion and meal and exercise announcement the optimal insulin injection necessary to safely regulate blood glucose can be calculated. | 10-14-2010 |
| 20100249561 | LQG Artificial Pancreas Control System and Related Method - The invention relates to a methods and systems for determining an insulin dosing recommendation. The invention employs Linear Quadratic methodology to determine the insulin dosing recommendation based on a patient's present physiological state, which is estimated by an adaptive filter methodology employing a dynamic model, which utilizes real-time measurements of blood glucose concentration. | 09-30-2010 |
| 20100247525 | COMPOSITIONS AND METHODS FOR TREATING ANTHRAX LETHALITY - The present invention provides compositions and methods for preventing and inhibiting anthrax lethality. The present invention relates to protect a subject from anthrax lethality by presensitizing a subject prior to anthrax infection. The present invention further provides compositions and methods for enhancing the innate system to inhibit anthrax-associated lethality. The invention further provides compositions and methods for preventing and inhibiting lethality due to infection regulated via a TNF-α pathway. | 09-30-2010 |
| 20100242265 | THIN FILM BATTERY SYNTHESIS BY DIRECTED VAPOR DEPOSITION - The present invention relates to methods for forming one or more thin film layers on a substrate, to form a multilayer product such as a lithium battery cell. The method involves passing a gas stream comprising at least one doping agent and at least one entrained source material through a plasma; impinging the gas stream on a substrate; and reactively depositing the at least one doping agent, and the at least one entrained source material on the substrate. The present invention provides a method of fabricating a power cell having a plurality of layers, and a method of fabricating a battery by electrically connecting a current collecting layer of a first power cell to a current collecting layer of a second power cell. | 09-30-2010 |
| 20100241185 | STEERABLE EPICARDIAL PACING CATHETER SYSTEM PLACED VIA THE SUBXIPHOID PROCESS - The epicardial pacing system and related method includes an epicardial catheter configured to be disposed in the middle mediastinum of the thorax of a subject for use in electrical pacing of the heart at one or more locations on the epicardial surface. The epicardial pacing catheter may include at least one electrode whereby the electrode is insulated on at least one side to allow pacing of the heart without damage to adjacent anatomical structures. | 09-23-2010 |
| 20100240617 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 09-23-2010 |
| 20100236759 | Heat-Managing Composite Structures - Light-weight, heat-managing structures feature open-cell lattice, honeycomb, and/or corrugated (prismatic) arrangements in their substructures, combined with heat pipe/heat plate arrangements for managing heat to which the structures are subjected. The structures are well suited to aerospace applications and may be employed in the leading edge of wings or other airfoil-shaped components; gas turbine engine components; rocket nozzles; and other high-heat, high-stress environments. | 09-23-2010 |
| 20100222406 | T Type Calcium Channel Blockers and the Treatment of Diseases - The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to the mammal a therapeutically effective amount of a T type calcium channel inhibitor, a prodrug thereof, or a pharmaceutically acceptable salt of said inhibitor or prodrug, wherein the T type calcium channel inhibitor has a structure represented by Formula (I): Formula (I), wherein R | 09-02-2010 |
| 20100221137 | Hydrogen Storage Material with Intermediate Bond Strength and Process for Making the Same - Provided herein are materials that can achieve up to 14% hydrogen absorption by weight in ambient conditions, which is a marked improvement over the hydrogen absorption values found in the prior art. Further provided are experimental conditions necessary to produce these materials. In order to produce the hydrogen storage material, a transition metal (or Lithium) is vaporized in a pi bond gas in conditions that permit only a few bonding collisions to occur between the vaporized transition metal atoms and pi bond gas molecules before the resulting bonded material is collected. | 09-02-2010 |
| 20100219506 | Systems and Methods of Laser Texturing and Crystallization of Material Surfaces - The surface of a material is textured and crystallized in a single step by exposing the surface to pulses from an ultrafast laser. The laser treatment causes pillars to form on the treated surface. These pillars provide for greater light absorption. The crystallization of the material provides for higher electric conductivity and changes in optical properties of the material. The method may be performed in a gaseous environment, so that laser assisted chemical etching will aid in the texturing of the surface. This method may be used on various material surfaces, such as semiconductors, metals, ceramics, polymers, and glasses. | 09-02-2010 |
| 20100211064 | Electrode Catheter for Ablation Purposes and Related Method Thereof - An electrode catheter for use with an endocardial ablation catheter, wherein the electrode catheter receives the transmitted energy for ablating a portion of the heart. The electrode catheter comprises a proximal portion, a distal portion, and a longitudinal structure there between; and an electrode in communication with said electrode catheter, wherein said electrode receives the transmitted energy from the endocardial ablation catheter, or alternatively an epicardial ablation catheter. | 08-19-2010 |
| 20100210927 | MEANS AND METHODS FOR CYTOMETRIC THERAPIES - A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient. | 08-19-2010 |
| 20100203144 | Immobilized Metallic Nanoparticles as Unique Materials for Therapeutic and Biosensor Applications - The present invention relates to compositions and methods by which surface modification techniques can be used to modify wide range polymeric or metal substrates using metal nanoparticles. | 08-12-2010 |
| 20100198520 | Method, System and Computer Program Product for Evaluation of Insulin Sensitivity, Insulin/Carbohydrate Ratio, and Insulin Correction Factors in Diabetes from Self-Monitoring Data - A method, system and computer program product for evaluating or determining a user's insulin sensitivity (SI). An initial step or module may include acquiring SMBG readings from a predetermined period. Another step or module may include computing an estimate of insulin sensitivity (SI) from the SMBG readings. Another step or module may include using the estimate of SI to compute individualized carbohydrate ratio. Additionally, another step or module may include using the estimate of SI to compute individualized correction factor. The computation of the two components of an insulin dose calculator, carbohydrate ratio and correction factor, uses this estimate, which allows the tailoring of carbohydrate ratio and correction factor to the present state of the person. | 08-05-2010 |
| 20100198137 | Coaxial Catheter Systems for Transference of Medium - A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting an inner tube into the outer tube and aligning them such that port holes on both of the tubes will overlap and permit a flux of the therapeutic agent to flow into the brain in such a way as to minimize the effects of trapped air, virtually eliminate backflow of the agent, and avoid the potential for additional damage to the brain since only one surgical placement of the outer tube is needed. Similarly, the method, technique system may be utilized to remove fluids or other medium from the brain, tissues, and organs to minimize the effects of escaped air or negative pressure. | 08-05-2010 |
| 20100198090 | Method, System and Computer Program Product for Controlling Complex Rhythmic Systems - A method, apparatus, and computer program product for controlling the behavior of complex rhythmic systems, such as the nervous system, is disclosed. Robust, engineering based measurements of the rhythmic system are taken and used to generate feedback that guides the system towards a desired state. This methodically designed feedback allows the system to maintain the normal behavior of individual elements, thereby achieving high effectiveness, while at the same time minimizing side effects. It therefore becomes possible to move the system towards the desired state in a non-destructive manner. This approach also allows for increased flexibility and applicability because the feedback is generated in a manner that is tailored to the unique variables of the particular system. | 08-05-2010 |
| 20100194225 | Self Sensing Integrated System and Method for Determining the Position of a Shaft in a Magnetic Bearing - A magnetic bearing system and related method that utilizes self-sensing in order to determine and adjust the position of a shaft within the bearing. Magnetic bearings levitate a rotating object with a magnetic field and are unstable in open-loop operation. Position feedback control is required to maintain a rotor in a centered position. The system and related method uses a unique design to sense the position of the rotating object with greater accuracy. It comprises coils which are used both to detect and adjust the position of the rotating object and a control system which supplies signals in a time-multiplexed manner in order to determine the position with accuracy while still allowing the same coils that are used to detect position to also supply a field to control the position of the rotor. | 08-05-2010 |
| 20100191099 | MOTION-ATTENUATED CONTRAST-ENHANCED CARDIAC MAGNETIC RESONANCE IMAGING AND RELATED METHOD THEREOF - A system and method for providing a dark-blood technique for contrast-enhanced cardiac magnetic resonance, improving visualization of subendocardial infarcts or perfusion abnormalities that may otherwise be difficult to distinguish from the bright blood pool. In one technique the dark-blood preparation is performed using a driven-equilibrium fourier transform (DEFT) preparation with motion sensitizing gradients which attenuate the signal in the ventricular cavities related to incoherent phase losses resulting from non-steady flow within the heart. This dark-blood preparation preserves the underlying contrast characteristics of the pulse sequence causing a myocardial infarction to be bright while rendering the blood pool dark. When applied to perfusion imaging, this dark-blood preparation will help eliminate artifacts resulting from the juxtaposition of a bright ventricular cavity and relatively dark myocardium. | 07-29-2010 |
| 20100184643 | Methods and Compounds Regulating the Erythroid Response to Iron Deficiency - The present invention discloses the signaling pathway involved in erythroid repression by iron deficiency. Further disclosed is a non-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakary-ocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation. | 07-22-2010 |
| 20100183617 | COMPOSITIONS AND METHODS FOR REGULATING SAS1R - The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor. Six SAS1R variants, including the full length SAS1R, were identified. mSLLP1 and SAS1R co-localized to oocytes and to acrosomes of acrosome-reacted sperm. Interactions between mSLLP1 and SAS1R were demonstrated by far-western analysis, in a yeast two-hybrid system under stringent selection conditions, and by immunoprecipitation of SAS1R by anti-mSLLP1 as well as the converse. Purified recombinant SAS1R was found to have protease activity, to inhibit fertilization in-vitro, and to induce an immune response in females. Together, the results suggest SAS1R is a proteolytically active, oocyte and early embryo specific oolemmal metalloprotease receptor for the sperm intra-acrosomal ligand SLLP1 and is a target for regulating fertilization and as a contraceptive. | 07-22-2010 |
| 20100183519 | Topical Poloxamer Formulations for Enhancing Microvascular Flow: Compositions and Uses Thereof - This invention relates to therapeutic compositions comprising a surface active copolymer, such as poloxamer-188, in an amount effective to enhance microvascular blood flow and/or inflammation in injured skin or other tissue, and methods of using the therapeutic compositions of the invention to inhibit decreased blood flow associated with an injury, disease, or disorder. | 07-22-2010 |
| 20100179768 | Method, System and Computer Simulation Environment for Testing of Monitoring and Control Strategies in Diabetes - A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes. | 07-15-2010 |
| 20100168578 | System and Method for Combined ECG-Echo for Cardiac Diagnosis - A system and related method for obtaining volumetric cardiac data of a subject. The data is generated by forming a plurality of focused ultrasound images corresponding to a series of ranges, generating myocardial boundary data for each of the plurality of ultrasound images, calculating the area of the region defined by said myocardial boundary data for each of the plurality of ultrasound images, multiplying the area for each of the plurality of ultrasound images by a slice depth corresponding to said ultrasound image to obtain the slice volume of each slice, and summing the slice volumes to obtain a total volume. In an alternative embodiment the system and related method combine an automated volumetric ultrasound system for finding chamber volumes and myocardial thicknesses, with a diagnostic electrocardiogram system to enable simultaneous diagnosis of mechanical and electrical cardiac problems. | 07-01-2010 |
| 20100168443 | Ethoid-Containing Compounds, Methods for Preparing Ethoid-Containing Compounds, and Methods of Use - Ethoid-containing compounds comprising one or more ethoid moieties (e.g., a methyleneoxy, Ψ[CH | 07-01-2010 |
| 20100160896 | Blood Flow Bypass Catheters and Methods for the Delivery of Medium to the Vasculature and Body Ducts - A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, continuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion. Different embodiments of the catheterization device are disclosed and indications for the use of these devices in the treatment of vascular diseases are discussed. | 06-24-2010 |
| 20100152623 | Systems, Devices and Methods for Interpreting Movement - According to some exemplary embodiments, a method or system can involve associating a plurality of biokinetographic comparison results with a first specific dysfunction from a group of specific dysfunctions, each of the biokinetographic comparison results obtained from a comparison of a biokinetographic value to a standard for a corresponding biokinetographic variable. | 06-17-2010 |
| 20100152127 | 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF - The invention provides compounds having the following general formula (I): | 06-17-2010 |
| 20100143744 | Systems and Methods of Laser Texturing of Material Surfaces and their Applications - The surface of a material is textured and by exposing the surface to pulses from an ultrafast laser. The laser treatment causes pillars to form on the treated surface. These pillars provide for greater light absorption. Texturing and crystallization can be carried out as a single step process. The crystallization of the material provides for higher electric conductivity and changes in optical and electronic properties of the material. The method may be performed in vacuum or a gaseous environment. The gaseous environment may aid in texturing and/or modifying physical and chemical properties of the surfaces. This method may be used on various material surfaces, such as semiconductors, metals and their alloys, ceramics, polymers, glasses, composites, as well as crystalline, nanocrystalline, polycrystalline, microcrystalline, and amorphous phases. | 06-10-2010 |
| 20100142781 | Systems and Method for Adaptive Beamforming for Image Reconstruction and/or Target/Source Localization - Methods, systems and computer readable media for reconstruction of target locations and amplitudes from signals received from one or more real targets in a space are provided, wherein the signals are at least one of signals received from the near-field and broadband signals. The space is modeled as a region of interest, and an array manifold matrix is calculated from signals received from hypothetical targets in the region of interest. One or more signal vectors received from the one or more real targets are reshaped into a data vector. A hypothetical target configuration is identified that, when applied to a signal model comprising the array manifold matrix, matches the data vector, a reconstruction vector is calculated. The reconstruction vector is reshaped into a reconstructed representation of the real targets in the space, and at least one of outputting the reconstructed representation for viewing by a user, and storing the reconstructed representation for later use are performed. | 06-10-2010 |
| 20100120115 | Compositions and Methods for Making and Using Laminin Nanofibers - The present invention encompasses methodologies and parameters for the formation of nanofibrous (to microfibrous) laminin via electrospinning. The present application discloses conditions and appropriate parameters to synthesize laminin fibers from a diameter of about 10 nM to a diameter of over 1,000 nM via electrospinning. | 05-13-2010 |
| 20100120058 | IgE Antibodies to Chimeric or Humanized IgG Therapeutic Monoclonal Antibodies as a Screening Test for Anaphylaxis - The present invention provides an assay for detecting serum IgE antibody levels to cetuximab and to other proteins. The present invention further provides a method for predicting whether a subject will respond adversely to cetuximab treatment. The present further provides a method for detecting sensitivity to compounds comprising galactose-alpha-1,3-galactose. | 05-13-2010 |
| 20100114093 | Epicardial Ablation Catheter and Method of Use - An aspect of various embodiments of the present invention system and method provide, but not limited thereto, a novel means for epicardial ablation using a double-curve steerable sheath and a double-curve deflectable open irrigated-tip/suction catheter that can be guided around the apex of the heart and adjusted so as to position the distal tip optimally. The catheter can also both deliver fluid to and withdraw fluid from the pericardial space. Access to the epicardial surface of the heart is via a subxiphoid entry. The method and means presented include, but are not limited to, steering, energy delivery, bipolar mapping, placement and use of electrodes, irrigation, suction of irrigation fluid, and other details of the subject invention. | 05-06-2010 |
| 20100112031 | Compositions And Methods For Regulating Extracellular Matrix Production In Adipose Derived Cells - The present application provides compositions and methods for regulating ECM production in ASCs and for isolating and using the various ECM molecules. The present application further provides methods for inducing various growth factors, cytokines and stem cell markers. | 05-06-2010 |
| 20100111897 | Methods and Compositions Useful for Diabetic Wound Healing - The invention provides compositions and methods useful for treating wounds and enhancing wound healing, particularly for diabetic wound healing. | 05-06-2010 |
| 20100109463 | Hybrid Five Axis Magnetic Bearing System Using Axial Passive PM Bearing Magnet Paths and Radial Active Magnetic Bearings with Permanent Magnet Bias and Related Method - An extremely energy efficient, compact, integrated hybrid five axis passive and active magnetic bearing system is developed for suspending a rotor within a non-rotating stator without conventional rolling element or fluid film bearings wherein 1) an axial permanent magnetic set of poles generates a magnetic flux path creating an axial repulsive force which keeps the rotor axially centered in the stator without using a thrust disk or radial thrust faces, 2) two radial electromagnetic bearings generate radial magnetic flux paths which create radial forces which keep the rotor radially centered in the housing, and 3) an integrated axial/radial permanent flux path which provides a bias flux for the radial bearings. | 05-06-2010 |
| 20100104819 | INTERWOVEN SANDWICH PANEL STRUCTURES AND RELATED METHOD THEREOF - An interwoven sandwich panel structure made for high intensity impulse mitigation comprises a top and bottom face panel integrally interwoven to a core by creating a preform from the interweaving of cross-wise and length-wise threads and then infusing it with a thermoset polymer resin such that it requires no stitching, bonding, or fastening to attach core to the face panels removing the primary weak points of a sandwich panel structure. | 04-29-2010 |
| 20100098739 | COMPOSITIONS AND METHODS FOR MODULAR SOFT TISSUE REPAIR - Adipose tissue-derived stromal cells induced to form multicellular aggregates can be formed reliably and consistently, they can be maintained for prolonged periods in adherent or suspension culture, and they are able to survive, grow, and/or differentiate in serum-free media conditions. The present invention provides compositions and methods for the use of such aggregates in tissue repair. This culture platform provides a controlled and defined system in which to study and standardize adult stem cell biology, and begets an instinctive “modular” approach to the predictable replacement and regeneration of adipose tissue. | 04-22-2010 |
| 20100094143 | Access Needle Pressure Sensor Device and Method of Use - A tool and method of positioning and delivering medical devices and therapeutics within the pericardial space, as well as other body part or space. A needle is inserted into the chest through a sub-xiphoid puncture, and the pressure within the needle is monitored manometrically or otherwise sensed as the needle is advanced towards the pericardial space. By reading the pressure within the needle while it is advanced, the clinician is able to know that he or she is avoiding insertion of it into organs or spaces not intended to be the target location. In addition the retractable sharp edge allows the operator to access the space and cut tissue but do so safely by retracting the sharp edge. | 04-15-2010 |
| 20100087924 | Expandable Intervertebral Prosthesis Device for Posterior Implantation and Related Method Thereof - A method and device for the insertion of a vertebral cage that may be done through a posterior approach that is minimally traumatic and does not require retraction of the spinal cord, dural sac or spinal nerves. The insertion of the cage may therefore be parallel to the spinal cord and the cage will be rotated ninety degrees (or as desired or required) in the vertebral body defect or as applicable to achieve its proper positioning before expansion. | 04-08-2010 |
| 20100076346 | Method and System for Energy Returning Ankle Foot Orthosis (ERAFO) - An orthotic device/system and method including at least one energy storage component and at least one trigger component which prevents release of the stored energy until the desired point in the movement cycle of an extremity. Use of the device/system and method permits, among other things, the orthosis to capture energy from the force present between a patient and a supporting surface and return it at a specified point in the movement cycle of the subject's extremity. | 03-25-2010 |
| 20100076006 | Topiramate Plus Naltrexone for the Treatment of Addictive Disorders - The present invention provides for the use of combinations of drugs to treat addictive disorders. | 03-25-2010 |
| 20100074887 | Methods for Treating and Diagnosing Fibrotic and Fibroproliferative Diseases - The present invention provides compositions and methods for diagnosing and treating fibrotic lung disease. | 03-25-2010 |
| 20100063510 | Expandable Intervertebral Prosthesis Device for Posterior Implantation and Related Method Thereof - A method and device for the insertion of a vertebral cage that may be done through a posterior approach that is minimally traumatic and does not require retraction of the spinal cord, dural sac or spinal nerves. The insertion of the cage may therefore be parallel to the spinal cord and the cage will be rotated ninety degrees (or as desired or required) in the vertebral body defect or as applicable to achieve its proper positioning before expansion. | 03-11-2010 |
| 20100057043 | Method, System, and Computer Program Product for the Detection of Physical Activity by Changes in Heart Rate, Assessment of Fast Changing Metabolic States, and Applications of Closed and Open Control Loop in Diabetes - A method, system, and computer program product related to the detection of physical activity using changes in heart rate. The method, system, and computer program product evaluates short term glucose demand and long term insulin action due to physical activity. The method, system, and computer program product is further related to the improvement of open and closed loop control of diabetes by accounting for the metabolic changes due to physical activity. The method, system, and computer program product is directed to detecting in real time the short and long term effects of physical activity on insulin action via heart rate analysis, and recommending changes in insulin dosing to compensate for the effects of physical activity. With these recommendations, the open and closed loop control of diabetes can be improved and steps can be taken to prevent hypoglycemia that may result from increased insulin sensitivity due to physical activity. | 03-04-2010 |
| 20100056940 | Method, System and Computer Program Product for Non-Invasive Classification of Cardiac Rhythm - The invention relates to a method for analysis of cardiac rhythms, based on calculations of entropy and moments of interbeat intervals. The invention provides an optimal determination of segments of data that demonstrate statistical homogeneity, specifically with regard to moments and entropy. The invention also involves calculating moments and entropy on each segment with the goal of diagnosis of cardiac rhythm. More specifically, an absolute entropy measurement is calculated and provided as a continuous variable, providing dynamical information of fundamental importance in diagnosis and analysis. Through the present invention, standard histograms, thresholds, and categories can be avoided. | 03-04-2010 |
| 20100055723 | Galectin-3-Binding Protein as a Biomarker of Cardiovascular Disease - The present invention provides compositions and methods for using biomarkers to diagnose and monitor cardiovascular associated diseases and disorders. More specifically, the present invention provides Galectin-3-binding protein as a biomarker for disease. | 03-04-2010 |
| 20100042158 | Closure Device for Skull Plates and Related Method Thereof - A method and means of cranial bone flap fixation that provides, among other things, the re-opening, resetting and/or repositioning of the bone flap during neurosurgical procedures. The instrumentation central to this method and means is MR and CT-visible to aid in imaging-based localization of it. The method and means can also be used in other types of medical procedures where certain kinds of hard or firm tissue fixation is desirable according to the method of the invention. | 02-18-2010 |
| 20100041689 | Combined Effects of Topiramate and Ondansetron on Alcohol Consumption - The present invention provides for the use of combinations of drugs to treat addictive disorders. More specifically, the present invention relates the use of drugs in conjunction with behavioral intervention to treat alcohol-related diseases and disorders as well as treatment of obesity and regulating weight. | 02-18-2010 |
| 20100016245 | RHAMNOSE SUBSTITUENTS OF SL0101 AND THERAPEUTIC USES THEREOF - The present invention provides compositions and methods useful for preparing and using analogs, derivatives, and modifications of kaempferols that have anti-neoplastic activity. More specifically, the compounds are analogs, derivatives, and modifications of SLO1O1. The invention further provides compounds that are inhibitors of rsk activity. The invention further provides compounds that selectively inhibit excessive rsk activity in cancers. The present invention further provides methods for treating cancer using compounds of the invention. | 01-21-2010 |
| 20100003193 | UNIT DOSAGE OF APADENOSON - The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging. | 01-07-2010 |
| 20100000770 | Conducting Nanotubes or Nanostructures Based Composites, Method of Making Them and Applications - An electromagnetic interference (EMI) shielding material includes a matrix of a dielectric or partially conducting polymer, such as foamed polystyrene, with carbon nanotubes or other nanostructures dispersed therein in sufficient concentration to make the material electrically conducting. The composite is formed by dispersing the nanotube material in a solvent in which the dielectric or partially conducting polymer is soluble and mixing the resulting suspension with the dielectric or partially conducting polymer. A foaming agent can be added to produce a lightweight foamed material. An organometallic compound can be added to enhance the conductivity further by decomposition into a metal phase. | 01-07-2010 |
| 20090312252 | Antimicrobial Activity in Variants of Lacritin - The present invention provides recombinant proteins with antimicrobial activity and methods for treating animals including humans by administering the novel recombinant proteins. In particular, the invention provides methods for treating and/or preventing microbial diseases and infections using lacritin and homologs, fragments, modifications, and derivatives thereof. | 12-17-2009 |
| 20090304643 | Methods of Preparing and Characterizing Mesenchymal Stem Cell Aggregates and Uses Thereof - The invention provides compositions and methods for preparing and characterizing multipotential mesenchymal stem cell aggregates. The invention further provides methods for using stem cell aggregates of the invention. | 12-10-2009 |
| 20090286910 | Viscoelastic and Dilatant Composition, Device and Method of Use and Manufacture - A device and related method having an elastic means and a damping means for controlling motion between objects or bodies. The elastic means and the damping means may be combined together to form a composite material, for which there is a method of use and manufacture. The device and related method may also utilize a dilatant-based material to oppose the rapid relative motion of two members. The objects or bodies, for example, may be a piece of furniture and the floor. In its application to furniture, this device and related method acts to keep all the legs on a piece of furniture in contact with the floor so that there is no rocking, and it acts to make those legs rigid on short timescales so that there is no bouncing or apparent unsoundness of the support. | 11-19-2009 |
| 20090286100 | Manufacture of Lattice Truss Structures from Monolithic Materials - Methods and systems to manufacture bonded corrugation truss-based structures. This allows the ability to change the dimensions of the individual structural features of the corrugations, i.e. thickness of the core, face sheet thickness, relative density of the core, and the alloys. The nodal design which provides ideal stress/strain distribution for in-plane and out-off plane loading. The node has a curved/smooth triple point intersection which in turn can provide best load transfer interface with high integrity/toughness. The bonded corrugation truss based structure can be continuous to any length only limited by the volume of the extrusion billet and the press capacity. An aspect of the bonded corrugation structures may include friction stir welding of the face sheets or any fusion welding of panels with edge members for strengthening allows fabrication of panels of any width and length. Bonding panels enables the fabrication of structures of any width. | 11-19-2009 |
| 20090282773 | Manufacture of Lattice Truss Structures from Monolithic Materials - Methods and systems to manufacture lattice-based sandwich structures from monolithic material. Such methods and systems eliminate the bonding process which is conventionally used to join lattice based truss cores to facesheets to form sandwich structures. This bonded interface is a key mode of failure for sandwich structures which are subjected to shear or bending loads because the nodes transfer forces from the face sheets to the core members while the topology for a given core relative density dictates the load carrying capacity (assuming adequate node-bond strength exists). An aspect comprises a core and related structures that provide very low density, good crush resistance and high in-plane shear resistance. An aspect of the truss structures may include sandwich panel cores and lattice truss topology that may be designed to efficiently support panel bending loads while maintaining an open topology that facilitates multifunctional applications. | 11-19-2009 |
| 20090280110 | Cell Model for Alzheimer's Disease Pathology - The present invention encompasses compositions and methods for studying in cell culture the pathologic changes associated with Alzheimer's disease. The present invention further relates to methods for studying and detecting early events in the conversion of healthy neurons to Alzheimer's disease neurons. | 11-12-2009 |
| 20090274865 | CELLULAR LATTICE STRUCTURES WITH MULTIPLICITY OF CELL SIZES AND RELATED METHOD OF USE - A sandwich panel core that may be comprised of a lattice structure utilizing a network of hierarchical trusses, synergistically arranged, to provide support and other functionalities disclosed herein. Since this design results in a generally hollow core, the resulting structure maintains a low weight while providing high specific stiffness and strength. Sandwich panels are used in a variety of applications including sea, land, and air transportation, ballistics, blast impulse mitigation, impact mitigation, thermal transfer, ballistics, load bearing, multifunctional structures, armors, construction materials, and containers, to name a few. | 11-05-2009 |
| 20090270514 | Methods for Regulating Gelation of Polysaccharide Solutions and Uses Thereof - The present invention provides a method for preparing chito san solutions to allow regulating the conditions in which the chitosan solution will gel. The present invention also provides methods for using chitosan solutions as compositions and for using chitosan solutions in vitro and in vivo. | 10-29-2009 |
| 20090230302 | Electron Transfer Dissociation for Biopolymer Sequence Analysis - The present invention relates to a new method for fragmenting ions in a mass spectrometer through the use of electron transfer dissociation, and for performing sequence analysis of peptides and proteins by mass spectrometry. In the case of peptides, the invention promotes fragmentation along the peptide backbone and makes it possible to deduce the amino acid sequence of the sample, including modified amino acid residues, through the use of an RF field device. | 09-17-2009 |
| 20090220487 | Methods and Compositions for Inhibition of Vascular Permeability - The present invention relates to methods and compositions for regulating vascular permeability. The present invention relates to methods and compositions for blocking proteins and signal transduction pathways involved in increasing vascular permeability. | 09-03-2009 |
| 20090214552 | Novel Egg Receptors for Sperm Proteins - The present invention relates to novel egg membrane protein receptors and to methods of inhibiting the interaction of sperm proteins with egg proteins. The invention further relates to methods of preventing and inhibiting sperm-egg binding, sperm-egg fusion, and fertilization. The invention further relates to the egg membrane proteins MET and ZEP. | 08-27-2009 |
| 20090195120 | Capillary Force Actuator Device and Related Method of Applications - An actuator capable of generates force by leveraging the changes in capillary pressure and surface tension that result from the application of an electrical potential. The device, which will be referred to as a Capillary Force Actuator (CFA), and related methods, employs a conducting liquid bridge between two (or more) surfaces, at least one of which contains dielectric-covered electrodes, and operates according to the principles of electro wetting on dielectric. | 08-06-2009 |
| 20090192487 | System and Method for Intracranial Implantation of Therapeutic or Diagnostic Agents - A system and related method for delivering the anti-tumoral agent carmustine or other types of diagnostic or therapeutic agents into the brain of a patient with a brain tumor includes an insertion device, a skull mount, and a reformulated geometry of the carmustine compound (or other material) optimized for use in the insertion device and for maximized biodegradation time. The insertion device may be front loaded with the carmustine material (or other material) and inserted through the mount on a skull, to the location of the brain tumor, where the carmustine (or other material) is then released. It should be appreciated that the diagnostic and/or therapeutic system and related method thereof are not necessarily limited to the brain of a subject. It may also be used in the organ structures or tubular structures, as well as portions and locations thereof. | 07-30-2009 |
| 20090171589 | Method, System and Computer Program Product for Evaluation of Blood Glucose Variability In Diabetes From Self-Monitoring Data - A system, computer program product, method and algorithm for evaluation of blood glucose variability—one of the most important parameters of diabetes management. An embodiment of the method may use routine self-monitoring blood glucose (SMBG) data collected over a period of 2-6 weeks, for example, based on a theory of risk analysis of blood glucose data. One aspect may include a method, system and computer program product for computing the Average Daily Risk Range (ADRR)—a measure of overall glucose variability. Another aspect may include a method, system, and computer program product for estimating separately the glucose variability in the hypoglycemic range via a Low BG Index (LBGI) and the glucose variability in the high BG range via High BG Index (HBGI) followed by a combination of the two indices into a single variability display. | 07-02-2009 |
| 20090156954 | Method, Apparatus and Computer Program Product For Assessment of Attentional Impairments - A method, apparatus, and computer useable medium that provides, among other things, a standardized test protocol for screening and evaluation of attentional impairment using EEG data. Further, the method, apparatus, and computer program product enhances existing psychological, behavioral, and physiological EEG data acquisition systems by introducing a sequential stochastic model procedure, and an intelligent data interpretation component capable of assessing EEG inconsistencies associated attentional impairments. Potential users of this product will be any person or organization that diagnoses or treats persons with attentional or cognitive impairments. The method can be used for initial screening and diagnosis of disorders associated with impaired attention, such as ADHD, as well as for treatment and evaluation of the effects of treatments, such as medication or additional therapies. | 06-18-2009 |
| 20090093005 | PROTEIN-BASED BIOMARKERS FOR ABDOMINAL AORTIC ANEURYSM - The present invention encompasses compositions and methods useful for diagnosing subjects with abdominal aortic aneurysms. The invention relates to the use of protein biomarkers whose levels are different in subjects with abdominal aortic aneurysms relative to normal subjects. | 04-09-2009 |
| 20090048577 | Multi-Port Catheter System with Medium Control and Measurement Systems for Therapy and Diagnosis Delivery - A series of embodiments of multi-lumen, multisegmented (or variable diameter) catheters and associated multi-channel flow control and measurement systems and methods for simultaneous delivery of a medium to a plurality of locations is described. The need for precise, stable reliable, and repeatable flow control in therapy delivery catheters is crucial to the efficacious treatment of the clinical manifestations of peripheral vascular disease (PVD) and other such maladies. Such treatments may involve the placement of multi-lumen catheters into peripheral arterial trees, with the subsequent need to govern the flow dynamics within each individual lumen of the multi-lumen device in such a way that an optimum distribution of the agent is achieved intra-arterially. Combinations of pumps, flow monitors, pressure monitors, feedback loops and related hardware and software collectively capable of achieving this goal are described. In other embodiments, this device and method could be used for infusions into tissues and solid organs, and microcoil systems can be added to the various components of the catheter systems to improve the imaging quality during MR-guided procedures. | 02-19-2009 |
| 20090030056 | NOVEL SODIUM CHANNEL BLOCKERS - The present invention is directed to novel phenyloin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis. | 01-29-2009 |
| 20090022712 | Compositions and Methods for Inhibiting Leukocyte Function - The present invention provides compositions and methods for regulating leukocyte migration and function. The present invention also provides compositions and methods for preventing and inhibiting lung injury and damage associated with neutrophil infiltration of the lung. | 01-22-2009 |
| 20090005869 | Device which Attaches into a Joint and Carries a Payload of Controlled Release Drugs and Related Method thereof - A device that is secured inside a human or animal joint. The device may include, but not limited thereto, the following components: 1) eyelets for suture; 2) endcaps; 3) a longitudinal core; 4) optional additional longitudinal members; and 5) a space for carrying a payload of controlled release drug. Numerous preparations of controlled release drugs have been proposed. This device acts as a platform for said preparations and drugs. It is distinguished by, among other things, its geometry and structural elements which are optimized for: 1) surgical passage into a joint; 2) stable attachment inside of a joint; and 3) secure carriage of the payload device for controlled release of drug. | 01-01-2009 |
| 20090003040 | Method and System For Encoding to Eliminate Parasitics in Crossbar Array Memories - A method of encoding data stored in a crossbar memory array, such as a nanowire crossbar memory array, to enable significant increases in memory size, modifies data words to have equal numbers of ‘1’ bits and ‘0’ bits, and stores the modified words together with information enabling the original data to be retrieved upon being read out from memory. | 01-01-2009 |
| 20080319678 | Mass Tagging for Quantitative Analysis of Biomolecules using 13C Labeled Phenylisocyanate - The present invention provides novel compositions and methods for mass-tagging peptides and proteins which are useful for identifying and quantifying mixtures of peptides and proteins. | 12-25-2008 |
| 20080318901 | Novel Lysophosphatidic Acid Receptor Selective Antagonists - The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom. | 12-25-2008 |
| 20080254037 | METHOD OF TREATING ISCHEMIA REPERFUSION INJURY BY INHIBING NKT CELL ACTIVITY - The present invention relates to a method for treating recurrent tumor metastases following liver resection that includes administration of an effective amount of an agonist of A | 10-16-2008 |
| 20080248003 | Methods and Compositions for Growing Adipose Stem Cells - The present invention relates to adipose tissue-derived stem cells and to methods and compositions for enhancing growth and differentiation of such cells. The invention further relates to growing such cells in serum-free or low serum growth medium, and formulations thereof. | 10-09-2008 |
| 20080220177 | Reliant Thermal Barrier Coating System and Related Methods and Apparatus of Making the Same - A method and apparatus for forming a thermal barrier coating system ( | 09-11-2008 |
| 20080213235 | Adipose Tissue Stem Cells, Perivascular Cells and Pericytes - The present invention provides methods for growing and inducing perivascular cell differentiation of adipose tissue-derived stromal cells. The invention further provides methods for administering such adipose tissue-derived cells to a subject. The cells of the invention are useful for treating diseases, disorders, conditions, and injuries requiring new or enhanced angiogenesis, vascular remodeling, drug delivery, and tissue engineering. | 09-04-2008 |
| 20080199967 | System for Detection of S-Nitrosoproteins - The present invention describes a novel, simplified method for detecting and monitoring the presence of nitrosylated proteins, such as S-nitrosoproteins, in a biological sample using fluorescence detection. The present invention further describes a method which can both quantify and identify the nature of nitrosylated proteins, which method is useful for monitoring both normal and disease states, in the development and screening of potential therapeutic drug species. | 08-21-2008 |
