| UNIVERSITY OF UTAH RESEARCH FOUNDATION Patent applications |
| Patent application number | Title | Published |
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| 20120135399 | CANCER BIOMARKER AND METHODS OF USING THEREOF - Described herein are biomarkers which can be used for identifying a subject at risk for or evaluating the progression of cancer. In certain aspects, these biomarkers can be used to identify cancer stem cells. These biomarkers can include, but are not limited to, Oc1 or molecular variants thereof, Oc1 target proteins, or a combination thereof. In addition, described herein are methods for reducing the expression of these biomarkers associated with cancer. | 05-31-2012 |
| 20120132891 | PRECISION QUANTUM DOT CLUSTERS - Precision quantum dot clusters and methods for producing and tuning quantum dot clusters are described herein. Also described herein are materials and devices, including photovoltaic devices, that may include one or more quantum dot clusters. | 05-31-2012 |
| 20120128554 | METHODS FOR AGGLOMERATING ORES - A method for making an agglomerate of an ore is disclosed. The method comprises contacting the ore with an acid solution and a stucco binder. The stucco binder may include calcium sulfate hemihydrate. The ore agglomerate may include ore, acid solution, and stucco-derived gypsum. | 05-24-2012 |
| 20120122803 | ALPHA-CONOTOXIN MII ANALOGS - The invention relates to novel conopeptides and/or novel uses of conopeptides. The conopeptides of the invention are analogs of α-Conotoxin MII that are selective for α6-containing nAChRs as described herein. | 05-17-2012 |
| 20120121719 | METHODS OF MAKING AND USING THREE-DIMENSIONAL EXTRACELLULAR MATRICES - Three-dimensional extracellular matrices lacking synthetic scaffolds are provided. Methods of making the three-dimensional extracellular matrices and methods of using the three-dimensional extracellular matrices are also provided. | 05-17-2012 |
| 20120095077 | METHODS AND COMPOSITIONS RELATED TO MODIFIED GUANINE BASES FOR CONTROLLING OFF-TARGET EFFECTS IN RNA INTERFERENCE - Disclosed are compositions and methods related to modified nucleobases. Also disclosed are compositions and methods related to modified interfering RNAs. Also disclosed are compositions and methods related to modified guanine bases for controlling off-target effects in RNA interference. | 04-19-2012 |
| 20120090533 | LOW-TEMPERATURE SYNTHESIS OF COLLOIDAL NANOCRYSTALS - Low-temperature organometallic nucleation and crystallization-based synthesis methods for the fabrication of semiconductor and metal colloidal nanocrystals with narrow size distributions and tunable, size- and shape-dependent electronic and optical properties. Methods include (1) forming a reaction mixture in a reaction vessel under an inert atmosphere that includes at least one solvent, a cationic precursor, an anionic precursor, and at least a first surface stabilizing ligand while stirring at a temperature in a range from about 50° C. to about 130° C. and (2) growing nanocrystals in the reaction mixture for a period of time while maintaining the temperature, the stirring, and the inert-gas atmosphere. | 04-19-2012 |
| 20120089113 | INTRAOCULAR DRUG DELIVERY DEVICE AND ASSOCIATED METHODS - Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an ocular active agent delivery device ( | 04-12-2012 |
| 20120084068 | Incorporation of Uncertainty in Simulation Analysis - A computing device simulates a test system by defining parameter values to be used to populate certain modeling formulas defining the test system. The defined parameter values correspond to one of the many points defining a domain in which the test system is to be simulated. The simulation iteratively solves the modeling formulas for each unit of the test system model space for each point in the domain in which the test system is simulated. Results for the subjects of interest are calculated at each iteration using the populated modeling formulas. A variance of the subjects of interest is also calculated at each iteration using a correlation coefficient obtained for the subjects of interest. The iterations of defining the parameter values and calculating the value and variance of the subjects of interest in the test system model space continues until all points in the domain have been simulated. | 04-05-2012 |
| 20120083687 | Retrospectively Correlated Turbo Spin Echo Imaging - Systems and methods which generate a sequence of images using turbo spin echo magnetic resonance imaging which are retrospectively correlated with periodic motion occurring within a subject being imaged are described. In one embodiment, k-space measurements (or the measurements from which images are formed) are captured during, and correlated with, different phases in a cardiac cycle of the subject. With this sequence, the images that are produced are able to show, and/or compensate for, motion correlated with the cardiac cycle of the subject. | 04-05-2012 |
| 20120083465 | METHOD FOR BLOCKING LIGATION OF THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS (RAGE) - A method and medicament is provided for treating and inhibiting interaction of the receptor for advanced glycation end-products (RAGE) and its ligands using a natural or synthetic sulfated polysaccharide, preferably a 2-O desulfated heparin. The medicament preferably is administered intravenously, by aerosolization, intra-nasally, intra-articularly, intra-thecally, subcutaneously, topically or orally. The medicament is useful for treating a variety of conditions, including diabetes, inflammation, renal failure, aging, systemic amyloidosis, Alzheimer's disease, inflammatory arthritis, atherosclerosis, and colitis. | 04-05-2012 |
| 20120082355 | Intrinsic Detection of Motion in Segmented Sequences - A self-navigating technique designed to detect motion in segmented sequences is disclosed. Certain embodiments compare a plurality of segments containing adjacent sets of k-space lines and produce an aliased error function which corresponds to a correlation of the segments. A global shift of the aliased error function may indicate the presence of in-plane rigid-body translation while other types of motion are evident in the dispersion or breadth of the error function. Some embodiments may then replace motion corrupted data with reacquired data. Further, some embodiments may correct or remove corrupted data retrospectively. | 04-05-2012 |
| 20120070443 | PDE1 AS A TARGET THERAPEUTIC IN HEART DISEASE - Disclosed are compositions and methods related to inhibition of PDE1. | 03-22-2012 |
| 20120068126 | POST-SYSTHESIS MODIFICATION OF COLLOIDAL NANOCRYSTALS - Methods for precise and predictable modification of previously synthesized nanocrystals. The methods rely on the solubility behavior of crystalline materials to provide for controlled reversal of the nanocrystal growth process (i.e., dissolution). A method for post-synthesis modification of colloidal nanocrystals includes (1) providing a first nanocrystal having a first size and a first shape, (2) forming a reaction mixture that includes the nanocrystal, at least one ligand capable of binding to at least one component of the nanocrystal, at least one solvent, and an inert gas atmosphere, and (3) modifying the size and/or shape of the nanocrystal in the reaction mixture for a period of time at a temperature in a range from about 100 0C to about 240 0C so as to produce at least a second nanocrystal having a second size and/or a second shape. | 03-22-2012 |
| 20120058161 | ALKYLATED SEMI SYNTHETIC GLYCOSAMINOGLYCOSAN ETHERS, AND METHODS FOR MAKING AND USING THEREOF - Described herein are alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated and alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including use for ocular or ophthalmic treatment. | 03-08-2012 |
| 20120046261 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND PREVENTING SPONTANEOUS PRETERM BIRTH - Disclosed herein are compositions and methods of identifying a subject at risk for preterm birth and selecting effective therapies for preventing preterm birth in the subject. The disclosed methods generally involve determining the identity of one or more nucleotides in the progesterone receptor (PR) gene of the subject. | 02-23-2012 |
| 20120039765 | DISINFECTING CAPS AND SYSTEMS AND ASSOCIATED METHODS - Caps can be used to cover and disinfect a male protrusion portion of a medical connector. Some caps can create a seal with the male protrusion to prevent antiseptic from entering a lumen the protrusion. A biasing element can aid in creating or maintaining the seal. | 02-16-2012 |
| 20120039764 | DISINFECTING CAPS AND SYSTEMS AND ASSOCIATED METHODS - Caps can be used to cover and disinfect a male protrusion portion of a medical connector. Some caps can create a seal with the male protrusion to prevent antiseptic from entering a lumen the protrusion. A biasing element can aid in creating or maintaining the seal. | 02-16-2012 |
| 20120021968 | METHODS FOR TREATING OR PREVENTING UROLOGICAL INFLAMMATION - Described herein are methods for treating or preventing urological inflammation in a subject comprising administering to the subject an effective amount of a compound comprising
| 01-26-2012 |
| 20110318738 | IDENTIFICATION AND REGULATION OF A NOVEL DNA DEMETHYLASE SYSTEM - Disclosed herein are methods and systems directed at detecting, evaluating, ameliorating, preventing and treating an oncogenic event. The disclosed methods and systems can comprise one or more Demethylase System Components or other compositions that can be used alone or in combination to detect, evaluate, treat, ameliorate, or prevent an oncogenic event. | 12-29-2011 |
| 20110306581 | STABLE PERFLUOROCARBON EMULSION FOR USE AS AN ARTIFICIAL OXYGEN CARRIER - Perfluorocarbon emulsions having a high stability and good oxygen release are disclosed and described. These perfluorocarbon emulsions are typically for use as artificial oxygen carriers. The perfluorocarbon emulsions include a disperse phase of a perfluorocarbon and an emulsion stabilizer, and continuous phase. The emulsion stabilizer can primarily include a poly(ethylene oxide) block copolymer. These stabilized perfluorocarbon emulsions can be used in liquid and/or hydrogel phases of perfusion bioreactors or various other culture systems to enhance cell viability in thick tissue constructs, or as blood substitutes, although other applications may also be considered. | 12-15-2011 |
| 20110301438 | DYE APPLICATION FOR CONFOCAL IMAGING OF CELLULAR MICROSTRUCTURE - A system and method for confocal imaging of tissue in vivo and in situ, e.g., for minimally invasive diagnosis of patients. A catheter is provided that has a dye carrier coupled to the distal end of a fiber optics bundle, which allows for the introduction of at least one fluorescent dye therein the dye carrier into a portion of the tissue of interest of a subject or patient when the dye carrier is selectively brought into contact with the portion of the tissue of interest. The resulting confocal images permit the acquisition of diagnostic information on the progression of diseases at cellular/tissue level in patients. Furthermore, a system for ECG-triggered image acquisition is provided. | 12-08-2011 |
| 20110294520 | System and Method for Preventing Cell Phone Use While Driving - A system for monitoring and controlling the use of a mobile computing device is disclosed. The system includes a data server ( | 12-01-2011 |
| 20110288566 | TISSUE STABILIZATION SYSTEM - Methods and systems are provided for tissue stabilization. Some aspects include a carrier member having a length, width, and thickness, wherein the length and width are each at least two times greater than the thickness; attachment members extending from the carrier member and that engage connective tissue; and stabilizing members, each of which can couple a respective attachment member to the carrier member and is substantially positionally fixed relative to the carrier member. | 11-24-2011 |
| 20110288565 | TISSUE FIXATION - Methods and apparatuses are provided for tissue fixation. In some aspects, an apparatus includes: a carrier member having a first part, a second part, and a junction therebetween; first attachment members protruding at a first angle from the first part toward the junction, where the first attachment members are configured to engage a first portion of connective tissue for attaching the first part to the first portion; and second attachment members protruding from the second part, where the second attachment members are configured to engage a second portion of connective tissue for attaching the second part to the second portion. When the first part is attached to the first portion and the second part is attached to the second portion, the first portion and the second portion are limited in being pulled apart from one another during physiological use of the connective tissue. | 11-24-2011 |
| 20110287923 | HIGH-TOUGHNESS ZETA-PHASE CARBIDES - A ceramic material having a high toughness can include carbon and a transition metal. The transition metal can have an elemental body centered cubic structure at room temperature. A substantial amount of the ceramic can be of a rhombohedral ζ phase of the transition metal and carbon. These materials can have a high thermal shock resistance, high fracture toughness, and good high temperature performance. A particulate mixture of a carbon source and a transition metal source can be assembled ( | 11-24-2011 |
| 20110280914 | HYDROGELS CROSSLINKED WITH GOLD NANOPARTICLES AND METHODS OF MAKING AND USING THEREOF - Described herein are composites useful in tissue and organ engineering. In one aspect, the composite comprises the reaction product between a macromolecule comprising at least one thiol group and a gold nanoparticle. The thiolated macro-molecule crosslinks with the gold nanoparticle to produce a composite that is useful in anchoring cells. The composites can be used to form multi-layer 3-D structures, where the cells in each layer can aggregate and fuse with one another to form tissues and organs. | 11-17-2011 |
| 20110278000 | GEOTHERMAL WELL DIVERSION AGENT FORMED FROM IN SITU DECOMPOSITION OF CARBONYLS AT HIGH TEMPERATURE - A method of selectively blocking fractures in a subterranean formation by injecting a diversion agent into the well is disclosed. According to one embodiment, the method comprises injecting a diversion agent into a subterranean formation to form an alkaline-earth carbonate precipitate from decomposition of a carbonyl compound, wherein the diversion agent includes the carbonyl compound and an alkaline-earth halide salt. | 11-17-2011 |
| 20110274356 | IMAGE PATTERN RECOGNITION - Image pattern recognition is described. In accordance with one embodiment, a method for image recognition includes dividing an image into blocks in preparation for separating a region of interest of the image from the remainder of the image. The blocks can be analyzed to determine whether a two dimensional projection of data from one or more blocks has a circular shape. The region of interest can be identified by identifying the blocks with circular shaped projections. | 11-10-2011 |
| 20110272503 | SYSTEMS AND PROCESSES FOR PRODUCING HIGH PURITY TRONA - A process of producing high purity trona concentrate includes crushing a mined raw trona ( | 11-10-2011 |
| 20110269713 | BRYOSTATIN ANALOGUES AND METHODS OF MAKING AND USING THEREOF - Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity. | 11-03-2011 |
| 20110263483 | COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY - Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical compositions are included in the compositions described herein. The compositions described herein are useful in, for example, methods of inhibiting vascular permeability and pathologic angiogenesis, including methods of inhibiting vascular permeability and pathologic angiogenesis induced by specific angiogenic, permeability and inflammatory factors, such as, for example VEGF, bFGF and thrombin. Methods for treating specific diseases and conditions are also provided herein. | 10-27-2011 |
| 20110263025 | BIODEGRADABLE POLYDISULFIDE AMINES FOR GENE DELIVERY - Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(N,N′-cystaminebisacrylamide-spermine), poly(N,N′-cystaminebisaciylamide-N,N′-bis(3-aminopropyl)1,3-propanediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(3-amino-propyl)ethylenediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(2-aminoethyl)-1,3-propanediamine), and poly(N,N′-cystaminebisacrylamide-triethylenetetramine). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and protected oligoamine monomers, followed by deprotection. Complexes are formed by mixing the poly(disulfide amine)s with a nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes. | 10-27-2011 |
| 20110262395 | SENSORY RECEPTORS FOR CHRONIC FATIGUE AND PAIN AND USES THEREOF - The present invention relates generally to the fields of pathological muscle pain/fatigue conditions. More specifically, the invention concerns methods and compositions useful for diagnosing and treating pathological muscle pain/fatigue conditions. | 10-27-2011 |
| 20110251135 | INHIBITORS OF PERITONEAL SEEDING OF CANCER CELLS - Disclosed compositions and methods for inhibiting NF-κB mediated cellular proliferation and metastasis. | 10-13-2011 |
| 20110247404 | IDENTIFYING AND QUANTIFYING BIOMARKERS ASSOCIATED WITH PREECLAMPSIA - Described herein are methods for testing pregnant subjects for preeclampsia by detecting and quantifying at least one biomarker associated with preeclampsia in a biological sample from the subject. | 10-13-2011 |
| 20110244434 | System and Method of Analyzing Freeform Mathematical Responses - A system and method are provided of analyzing a response expression in a freeform format as entered by a student in response to testing and practice questions presented by a computer system. The method can include parsing the response expression into tokens stored in a response expression tree. The system can determine whether the response expression tree is legal based on a defined grammar structure. Another operation is comparing a numerical evaluation of the response expression to a numerical evaluation of a reference expression. The similarity between the response expression and the reference expression can then be determined by comparing the response expression tree and a reference expression tree. Feedback can be supplied to the student regarding the overall correctness of the response expression as compared to the reference expression, based on correctness of each response expression element and the types of errors among response elements. | 10-06-2011 |
| 20110237838 | PROCESSES FOR CATALYTIC CONVERSION OF LIGNIN TO LIQUID BIO-FUELS AND NOVEL BIO-FUELS - Processes for conversion of lignin to products such as phenolic compounds and biofuels prepared from such phenolic compounds are disclosed and described. A process for conversion of a lignin material to bio-fuels can include subjecting the lignin material to a base catalyzed depolymerization reaction to produce a partially depolymerized lignin. The partially depolymerized lignin can then be subjected to a stabilization/partial hydrodeoxygenation reaction to form a partially hydrodeoxygenated product. Following partial hydrodeoxygenation, the partially hydrodeoxygenated product can be reacted in a hydroprocessing step to form a bio-fuel. Each of these reaction steps can be performed in single or multiple steps, depending on the design of the process. The production of an intermediate partially hydrodeoxygenation product and subsequent reaction thereof can significantly reduce or eliminate reactor plugging and catalyst coking. A variety of useful bio-fuels such as fuels, fuel additives, and the like, including gasoline and jet or rocket fuels are describe which can be readily produced from renewable lignin materials in an improved conversion process. | 09-29-2011 |
| 20110207232 | WATER SOLUBLE PH RESPONSIVE FLUORESCENT NANOPARTICLES - A nano-pH sensor can include a nanoparticle having an outer surface functionalized by a carboxy functional group. The nanoparticle is reversibly aggregated as a function of pH and is generally non-toxic. A fluorometer can be oriented to expose the nanoparticles to a light source at a given wavelength. Further, the fluorometer can be configured to detect changes in fluorescence of the gold nanoparticle with changes in pH. | 08-25-2011 |
| 20110206756 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF - Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) a dithiocarbamate metal chelate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. Methods for using the compositions in anticancer treatment and prevention are also described herein. | 08-25-2011 |
| 20110189769 | METHODS AND COMPOSITIONS FOR MANIPULATING THE GUIDED NAVIGATION OF ENDOTHELIAL TUBES DURING ANGIOGENESIS - Methods and compositions for manipulating the directed navigation of physiological tracking tubular structures are provided. A novel cell-bound receptor, roundabout-4 (Robo-4), is described. The Robo-4 receptor shows sequence and structural similarity to members of the roundabout family of receptors. Also, the Robo-4 receptor binds Slit ligand, a known receptor of the roundabout receptors. Polynucleotides and polypeptides of the Robo-4 receptor are described. | 08-04-2011 |
| 20110182978 | ACTIVATED NITRIC OXIDE DONORS AND METHODS OF MAKING AND USING THEREOF - Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O | 07-28-2011 |
| 20110178720 | METHOD AND SYSTEM FOR MEASURING ENERGY EXPENDITURE AND FOOT INCLINE IN INDIVIDUALS - A method and system for measuring energy expenditure of individuals by measuring force from a plurality of foot-borne force sensitive resistors and calculating incline from a foot-borne tri-axial accelerometer. | 07-21-2011 |
| 20110177005 | STABLE NANOEMULSIONS FOR ULTRASOUND-MEDIATED DRUG DELIVERY AND IMAGING - Described herein are nanoemulsions comprising (1) at least one fluoro ether and (2) a block copolymer comprising a hydrophilic block and hydrophobic block, wherein the nanoemulsion comprises a therapeutic agent in the nanoemulsion. The nanoemulsions are stable and are excellent drug delivery devices for ultrasound-mediated, image guided drug delivery. Also described herein are methods for using the nanoemulsions to treat tumors and cancers as well as using them as imaging agents. | 07-21-2011 |
| 20110137147 | MINIMUM TIME FEEDBACK CONTROL OF EFFICACY AND SAFETY OF THERMAL THERAPIES - A thermal treatment control system including an imaging device for specifying the geometry and/or location of the treatment target, a thermal energy element for applying a thermal treatment for the heating or cooling of a target tissue for therapeutic purposes, a thermal energy detecting element for detecting a measured tissue response to the thermal treatment and a feedback controller for a real-time modification of the intensity and spatial distribution of the thermal dose in order to achieve therapeutic efficacy over a minimum or reduced treatment time while satisfying treatment constraints imposed to limit damage to normal tissues. | 06-09-2011 |
| 20110118751 | Integrated Surgical Cutting System - Integrated surgical systems and methods for using same are provided that can receive scanned images and produce a three dimensional model from the images. Based at least in pan on the three dimensional model, a processor generates code defining an optimized tool path, which is sent to a surgical machining system that can machine the desired portion of the patient. In one exemplary aspect, the integrated system operates in a clearly defined and pre-programmed manner with no necessity for in-situ sensory or guidance feedback. | 05-19-2011 |
| 20110112053 | PHARMACOLOGICAL TARGETING OF VASCULAR MALFORMATIONS - Disclosed herein are compositions and methods for decreasing vascular permeability in a blood vessel and treating or preventing conditions associated with defects or injuries of vascular endothelium. For example, the disclosed compositions and methods can be used to treat a vascular dysplasia such as cerebral cavernous malformation (CCM). These methods relate generally to the use of compositions that inhibit RhoA GTPase levels or activity, such as inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. | 05-12-2011 |
| 20110093161 | INTEGRATED SYSTEMS AND METHOD FOR PREVENTING MOBILE COMPUTING DEVICE USE WHILE DRIVING - A system and method for controlling use of a mobile computing device in a vehicle are disclosed. The method comprises monitoring a vehicle-key system comprising a vehicle and a vehicle key having a particular code to determine when the vehicle has been activated using the vehicle key. An operational state of the vehicle is identified based on information received from an OBD port in the vehicle. The operational state of the vehicle is communicated to the mobile computing device. Use of selected device features on the mobile computing device are controlled based on the particular code of the vehicle key when the operational state of the vehicle indicates that the vehicle is outside of selected parameters. | 04-21-2011 |
| 20110085979 | CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS - Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. | 04-14-2011 |
| 20110084693 | SYSTEMS AND METHODS FOR IMAGE RECONSTRUCTION OF SENSITIVITY ENCODED MRI DATA - Methods and systems in a parallel magnetic resonance imaging (MRI) system utilize sensitivity-encoded MRI data acquired from multiple receiver coils together with spatially dependent receiver coil sensitivities to generate MRI images. The acquired MRI data forms a reduced MRI data set that is undersampled in at least a phase-encoding direction in a frequency domain. The acquired MRI data and auto-calibration signal data are used to determine reconstruction coefficients for each receiver coil using a weighted or a robust least squares method. The reconstruction coefficients vary spatially with respect to at least the spatial coordinate that is orthogonal to the undersampled, phase-encoding direction(s) (e.g., a frequency encoding direction). Values for unacquired MRI data are determined by linearly combining the reconstruction coefficients with the acquired MRI data within neighborhoods in the frequency domain that depend on imaging geometry, coil sensitivity characteristics, and the undersampling factor of the acquired MRI data. An MRI image is determined from the reconstructed unacquired data and the acquired MRI data. | 04-14-2011 |
| 20110082104 | ALKYLATED SEMI SYNTHETIC GLYCOSAMINOGLYCOSAN ETHERS, AND METHODS FOR MAKING AND USING THEREOF - Described herein is the synthesis of alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including wound healing, drug delivery, and the treatment of a number of inflammatory diseases and skin disorders. | 04-07-2011 |
| 20110078036 | Systems and methods for the assessment, protection, marketing and commercialization of technology-based ideas - The operations, methods and functions of a technology-based idea assessment, protection and connection system are described. The system involves new methods and computer based algorithms and networks to value technology based ideas, complete a quality assessment of the technology-based idea, package the technology-based idea and determine a cost-based strategy for protection of technology-based idea. The software-as-a-service system determines an output of an idea generator's strength in his technology or research network and suggests a path to commercialization. A protected technology-based idea is matched with a product development outlet such as a company, entrepreneur or executive manager to produce a faster commercialization outlet. The services and tools for the creation of technology-based start-ups are described. The system streamlines the costly and complicated process of technology commercialization by automatically aligning human and financial resources. | 03-31-2011 |
| 20110064668 | J-SUPERFAMILY CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors. | 03-17-2011 |
| 20110064326 | SYSTEMS AND METHODS FOR DEBLURRING DATA CORRUPTED BY SHIFT VARIANT BLURRING - The present invention provides methods, systems and machine readable medium including machine readable code for deblurring data corrupted by shift variant blurring. A first version of data having shift variant blurring characterized by a first shift variant point spread function is provided. A target shift invariant point spread function is selected. A second shift variant point spread function is derived wherein a combination of the first and second shift variant point spread functions generates the target shift invariant point spread function. The second shift variant point spread function is applied to the first version of the data thereby generating a second version of the data having shift invariant blurring characterized by the target shift invariant point spread function. A linear shift invariant filter is applied to the second version of the data thereby generating a deblurred version of the data. | 03-17-2011 |
| 20110046927 | FAST ITERATIVE METHOD FOR PROCESSING HAMILTON-JACOBI EQUATIONS - A system and method are provided for a parallel processing of the Hamilton-Jacobi equation. A numerical method is provided to solve the Hamilton-Jacobi equation that can be used with various parallel architectures and an improved Godunov Hamiltonian computation, | 02-24-2011 |
| 20110034389 | ACTIVE AGENTS, COMPOSITIONS, AND METHODS FOR INHIBITING AND REVERSING PLATELET FUNCTION - Active agents, compositions, and methods for inhibiting and reversing platelet function are provided herein. In particular embodiments, the active agents provided herein inhibit or reverse platelet function. In particular embodiments, the compositions described herein are pharmaceutical formulations. Methods of inhibiting and reversing platelet function are also provided herein. In particular embodiments, methods as described herein include administration of a Sema3E polypeptide. Further, methods of treating pathologic conditions associated with platelet function (i.e., platelet activation) and methods of screening active agent candidates are also provided. | 02-10-2011 |
| 20110015257 | Hypoxia Inducible VEGF Plasmid for Ischemic Disease - Plasmids useful for treating ischemic disease, such as ischemic heart disease, are described. The plasmids express vascular endothelial growth factor (VEGF) under the control of a promoter (RTP801) that is up-regulated under hypoxic conditions. Pharmaceutical compositions for treating ischemic disease include mixtures of the hypoxia-regulated VEGF plasmids and pharmaceutically acceptable carriers. Methods for treating ischemic disease include administering such pharmaceutical compositions to a person in need of such treatment. | 01-20-2011 |
| 20110014601 | Targeted Chromosomal Mutagenesis Using Zinc Finger Nucleases - The present invention provides for a method or methods of targeted genetic recombination or mutagenesis in a host cell or organism, and compositions useful for carrying out the method. The targeting method of the present invention exploits endogenous cellular mechanisms for homologous recombination and repair of double stranded breaks in genetic material. The present invention provides numerous improvements over previous mutagenesis methods, such advantages include that the method is generally applicable to a wide variety of organisms, the method is targeted so that the disadvantages associated with random insertion of DNA into host genetic material are eliminated, and certain embodiments require relatively little manipulation of the host genetic material for success. Additionally, it provides a method that produces organisms with specific gene modifications in a short period of time. | 01-20-2011 |
| 20100331931 | ECTOPARASITE ERADICATION METHOD AND DEVICE - A method of eliminating an ectoparasite infestation is disclosed that may include steps of defining a target area on an animal having an ectoparasite infestation, heating a volume of air to a temperature to form heated air, applying the heated air to the target area with an airflow such that the heated air impinges directly on substantially all ectoparasites located within the target area, and maintaining the heated air at the target area for a period of time sufficient to affect an ectoparasite mortality rate of at least 50%. | 12-30-2010 |
| 20100330143 | MODIFIED MACROMOLECULES AND METHODS OF MAKING AND USING THEREOF - Described herein are composites produced by reacting a first thiolated macromolecule with at least one compound having at least one thiol-reactive electrophilic functional group. The methods described herein permit the cross-linking of a variety of different thiolated macromolecules with one another. The composites described herein have a variety of biomedical and pharmaceutical applications, which are also described herein. | 12-30-2010 |
| 20100320094 | Nanopore Platforms for Ion Channel Recordings and Single Molecule Detection and Analysis - A nanopore device includes a membrane having a nanopore extending there through forming a channel from a first side of the membrane to a second side of the membrane. The surface of the channel and first side of the membrane are modified with a hydrophobic coating. A first lipid monolayer is deposited on the first side of the membrane, and a second lipid monolayer is deposited on the second side of the membrane, wherein the hydrophobic coating causes spontaneous generation of a lipid bilayer across the nanopore orifice. Sensing entities, such as a protein ion channel, can be inserted and removed from the bilayer by adjusting transmembrane pressure, and adapter molecules can be electrostatically trapped in the ion channel by applying high transmembrane voltages, while resistance or current flow through the sensing entity can be measured electrically. | 12-23-2010 |
| 20100317616 | ALKYLATED SEMI-SYNTHETIC GLYCOSAMINOGLYCAN ETHERS, AND METHODS OF MAKING AND USING THEREOF - Described herein is the synthesis of alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including wound healing, drug delivery, and the treatment of a number of inflammatory diseases and skin disorders. | 12-16-2010 |
| 20100316691 | BIODEGRADABLE INTRAVAGINAL MEDICAL DEVICE FOR DELIVERY OF THERAPEUTICS - The present disclosure relates to biodegradable intravaginal rings for the delivery of therapeutic or prophylactic agent, inter alia, antiviral agents. The present disclosure further relates to biodegradable polyurethanes which will allow therapeutic/prophylactic agents to be released in a controlled manner that will not degrade when in use, but will degrade upon disposal. | 12-16-2010 |
| 20100305918 | Ground-Coupled Heat Exchange for Heating and Air Conditioning Applications - The invention provides systems and methods for cooling and/or heating a structure. Generally, a system for heating or cooling a structure can include at least one thermosiphon in thermal communication with a thermal storage material such as a volume of earth. The thermosiphon can be partially filled with a heat transfer fluid and a heat exchanger operatively connected to the thermosiphon which is in thermal communication with the structure. Thermal energy can be transferred between the thermal storage material and the structure in either a passive or assisted mode, depending on whether the system is charging or in use. | 12-02-2010 |
| 20100305626 | ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF - Described herein is the synthesis of adhesive complex coacervates. The adhesive complex coacervates are composed of a mixture of one or more polycations, one or more poly anions, and one of more multivalent cations. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions. | 12-02-2010 |
| 20100297621 | USE OF PRE-MRNA SPLICING IN PLATELET CELLS FOR THE DIAGNOSIS OF DISEASE - The invention relates to materials and procedures for identifying or using tissue factor (TF) pre-mRNA splicing, CIk 1 activity or TF-dependent coagulation in platelet cells for the diagnosis, prognosis, or prediction of a disease or disorder associated with disordered coagulation. Since activated platelets splice pre-mRNAs to generate inflammatory and thrombotic mediators that contribute to diseases such as sepsis and septic shock, (TF) pre-mRNA splicing in platelets is an indicator of inflammatory and thrombotic disease states. TF pre-mRNA splicing in platelets is correlated with sepsis, increased age (≧65), APACHE II score, and bacteremia. Thus, TF mRNA expression patterns in platelets may be used for the diagnosis, prognosis, or prediction of a disease or disorder associated with disordered coagulation, for example, patients that are at a higher risk for severe sepsis, organ failure, and death. | 11-25-2010 |
| 20100285094 | POLYMERIC COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF - Described herein are polymeric compositions that comprise at least one polymer residue and at least one crosslinking moiety, wherein the polymer residue is crosslinked by the crosslinking moiety and wherein the crosslinking moiety is formed from a reaction between a boronic acid moiety and a hydroxamic acid moiety. Also, described are methods of making and using such polymeric compositions. | 11-11-2010 |
| 20100284927 | USE OF MRI CONTRAST AGENTS FOR EVALUATING THE TREATMENT OF TUMORS - Described herein are methods for using macromolecular MRI contrast agents to evaluate the effectiveness of anti-cancer treatments. The methods take advantage of MRI for evaluating more specifically and accurately one or more tumor properties of the tumor in response to a particular treatment. Ultimately, the 5 methods described herein help evaluate the effectiveness of the anti-cancer treatment over time. | 11-11-2010 |
| 20100271592 | APPARATUS FOR MEASURING CRITICAL FLICKER FUSION FREQUENCY AND METHODS OF USING SAME - Apparatuses and methods are provided for measuring the critical flicker fusion frequency of a subject. The apparatus in one aspect comprises two or more light sources, each flickering at a different predetermined frequency. The subject selects one light source from an array of light sources defining a first range of frequencies, the selection representing the light source of lowest frequency that appears as fused to the subject. The frequencies of the light sources are adjusted to second predetermined frequencies defining a second range. The subject selects the light source of lowest frequency that appears as fused to the subject. The frequency value of the second selection can be assigned as the subject's critical flicker fusion frequency. | 10-28-2010 |
| 20100267576 | Compositions And Methods For Identifying And Treating Subjects At Risk Of Developing Type 2 Diabetes - Disclosed herein are compositions and methods for the identification of a subject at risk for developing type 2 diabetes. Also disclosed is a therapeutic target for the prevention and treatment of type 2 diabetes. | 10-21-2010 |
| 20100267046 | ISOFORM-SELECTIVE INHIBITOR AND ACTIVATORS OF PDE3 CYCLIC NUCLEOTIDE PHOSPHODIESTERASES - The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isoforms and/or site-specific mutants of PDE3A isoforms, along with expression vectors encoding such isoforms or mutants. In specific embodiments, methods for identifying isoform-selective inhibitors or activators of PDE3 are provided, along with methods of use of such inhibitors or activators in the treatment of dilated cardiomyopathy, pulmonary hypertension and/or other medical conditions related to PDE3 effects on cAMP levels in different intracellular compartments. | 10-21-2010 |
| 20100267005 | Crosslinking Within Coordination Complexes - Crosslinked proteins, proteins and polymers, and polymers and methods of making the same are disclosed. In one illustrative embodiment, a method is provided comprising the steps of attaching a chelator to one or more polymers; creating a coordination complex between the first protein, the second protein, and a metal ion; and crosslinking the first and second proteins by exposing the coordination complex to an oxidant. | 10-21-2010 |
| 20100264425 | TRANSISTORS FOR REPLACING METAL-OXIDE-SEMICONDUCTOR FIELD-EFFECT TRANSISTORS IN NANOELECTRONICS - Junction field effect transistors (JFETs) are shown to be a viable replacement for metal oxide semiconductor field effect transistors (MOSFETs) for gate lengths of less than about 40 nm, providing an alternative to the gate leakage problems presented by scaled down MOSFETs. Integrated circuit designs can have complementary JFET (CJFET) logic cells substituted for existing MOSFET-based logic cells to produce revised integrated circuit designs. Integrated circuits can include JFETS where the channel comprises a wide bandgap semiconductor material and the gate comprises a narrow bandgap semiconductor material. Mixtures of JFET and MOSFET transistors can be included on an integrated circuit design. | 10-21-2010 |
| 20100248389 | ELECTROCHEMICAL DEPOSITION OF POLYMERS ON METAL SUBSTRATES - Described herein are methods for electrodepositing a variety of different polymers on metal substrates. The polymers are strongly adhered to the substrates. The substrates produced herein can be used in a number of different applications such as, for example, medical devices and biosensors. For example, the biosensors can be composed of one or more electrodes, where the electrodes have the same or different polymers electrochemically deposited on them. Finally, the methods described herein permit the evaluation of the electrodeposition process as well as monitor the ability of biomolecules to bind to the electrodeposited polymers. | 09-30-2010 |
| 20100233695 | MOLECULAR DIAGNOSIS AND TYPING OF LUNG CANCER VARIANTS - Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. The expression of the gene or biomarker is indicative of the lung tumor subtype. The compositions include subsets of genes that are monitored for gene expression. The gene expression is capable of distinguishing between normal lung parenchyma and the major morphological types of lung cancer. The gene expression and somatic mutation data are useful in developing a complete classification of lung cancer that is prognostic and predictive for therapeutic response. The methods are suited for analysis of paraffin-embedded tissues. Methods of the invention include means for monitoring gene or biomarker expression including PCR and antibody-based detection. The biomarkers of the invention are genes and/or proteins that are selectively expressed at a high or low level in certain tumor subtypes. Biomarker expression can be assessed at the protein or nucleic acid level. | 09-16-2010 |
| 20100222686 | MINIATURE WIRELESS BIOMEDICAL TELEMETRY DEVICE - Provided herein are embodiments of a miniature wireless biomedical telemetry device along with systems and methods for its use. A miniature amplifier and transmitter allow recording of physiological signals from small animals, such as rats, mice and birds, as well as humans. The device is positioned externally and is easily replaceable, as is its battery, so surgical complications and other problem problems are minimized. | 09-02-2010 |
| 20100222401 | COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY - Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis by modulating a signaling pathway delineated herein are described. Moreover, methods for producing and screening compounds and compositions capable of modulating the signaling pathway described herein, inhibiting vascular permeability, and inhibiting pathologic angiogenesis are also provided. | 09-02-2010 |
| 20100217342 | METHODS AND SYSTEMS FOR TREATING CARDIAC ARRHYTHMIAS - The disclosure includes methods and systems for treating cardiac arrhythmias. Some methods for treating an abnormal heart rhythm include determining a change in a sinus node cycle length of a heart of a patient between a time prior to the abnormal heart rhythm and a time during the abnormal heart rhythm; when the change is within a first range, delivering a first therapy to the patient for treating the abnormal heart rhythm; and when the change is within a second range, delivering a second therapy to the patient for treating the abnormal heart rhythm, wherein the first therapy is different from the second therapy. In some embodiments, the first therapy may include shock therapy and the second therapy may include anti-tachycardia pacing. | 08-26-2010 |
| 20100210471 | AUTISM ASSOCIATED GENETIC MARKERS - The present disclosure relates to the identification of a subject that is affected with, or predisposed to, autism or to one or more autism spectrum disorders (ASD). The present disclosure includes methods related to the association of certain genetic markers with autism and/or ASD. More particularly, the present disclosure is related to methods and diagnostic tests for diagnosing or predicting ASD in an individual. | 08-19-2010 |
| 20100199909 | SYSTEMS AND METHODS FOR RECYCLING SEMICONDUCTOR MATERIAL REMOVED FROM A RAW SEMICONDUCTOR BOULE - Methods of recycling excess semiconductor material removed from an unshaped semiconductor boule are disclosed. Excess semiconductor material is cut from an semiconductor unshaped boule thereby generating a shaped semiconductor boule. The excess semiconductor material is removed in the form of large pieces that can easily be cleaned and retrieved for reuse. | 08-12-2010 |
| 20100198554 | MEASUREMENT OF THICKNESS OF DIELECTRIC FILMS ON SURFACES - A system and method by which thickness of a dielectric film on substrates can be noninvasively determined is invented. The system and method are especially applicable to areas and applications where traditional techniques have proven unsuccessful or limited. According to embodiments of the present invention the present system and method can be used to measure film thickness in confined and inaccessible locations, and on substrates of complex geometry. The method can be used with an arbitrary and time varying orientation of the substrate-film interface. The measurements of the film thickness on the inside of open or enclosed channels of an arbitrary geometry, and on flexible substrates are possible. With multiple embedded sensors, the film thickness in different lateral locations can be simultaneously measured. The dielectric permittivity of the FUT as a function of the distance from the substrate of the film can also be measured. | 08-05-2010 |
| 20100197567 | CONUS POLYPEPTIDES - The invention relates to peptides (termed propeller peptides herein) and related peptides (termed peptides of the G12.2 family herein), about 60 to about 90 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which blocks the desensitization of AMPA-type ionotropic glutamate receptors (AMPARs). | 08-05-2010 |
| 20100187203 | MULTI-WIRE ELECTRON DISCHARGE MACHINE - A multi-wire electron discharge machine includes a first wire electrode for creating an electrical discharge between the first electrode wire and a semiconductor ingot, a second wire electrode for creating an electrical discharge between the second electrode wire and the semiconductor ingot, and a wire guide for maintaining the first wire electrode in a spaced apart and generally parallel orientation with respect to the second wire electrode across a semiconductor ingot slicing area. | 07-29-2010 |
| 20100178696 | IN VIVO GENOME-WIDE MUTAGENESIS - Disclosed herein are compositions and methods for deleting or duplicating DNA in a mammalian genome. Also disclosed are compositions and methods for generating a random genome-wide chromosome rearrangement. Also disclosed are compositions and methods for streamlined construction of gene targeting vectors. | 07-15-2010 |
| 20100178305 | ULTRASONIC NANOTHERAPY OF SOLID TUMORS WITH BLOCK COPOLYMERS STABILIZED PERFLUOROCARBON NANODROPLETS - Described herein are methods of treating a tumor by contacting the tumor with a therapeutic agent encapsulated in a first nanoemulsion and exposing the tumor to a first ultrasonic radiation of less than 300 kHz to the tumor. In some aspects, the tumor can be contacted with a second nanoemulsion. In some aspects, the second emulsion can be injected directly into the tumor via intratumoral injection before exposing the tumor to the first ultrasonic radiation. In some aspects, the tumor is exposed to a second ultrasonic radiation from about 1 to 5 MHz after the first ultrasonic radiation. The methods described herein can be used to treat numerous tumors including, but not limited to, multidrug resistant tumors and inoperable tumors. These tumors may include, but are not limited to, breast cancers, ovarian cancers, pancreatic cancers, or any combination thereof. | 07-15-2010 |
| 20100167421 | METHODS FOR IDENTIFICATION AND PREDICTION OF MULTIPLE SCLEROSIS DISEASE AND THERAPY RESPONSE - Methods and compositions for diagnosing multiple sclerosis (“MS”) in an individual or the predisposition or risk of MS, and for the prediction of the response to treatment of MS in an individual. More particularly, methods and compounds for the use of clinical, neuroradiological, genetic, biological and/or immunological markers as prognostic indicators, diagnostic markers, or predictors of response to MS therapy. | 07-01-2010 |
| 20100167288 | Methods and Compositions Related to Continuous Flow Thermal Gradient PCR - Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR. | 07-01-2010 |
| 20100166743 | METHOD OF DETECTING OCULAR DISEASES AND PATHOLOGIC CONDITIONS AND TREATMENT OF SAME - Methods of detecting and treating diseases and pathological conditions of the eye are disclosed. In particular a genetic variant of the HtrA1 gene is correlated to age related macular degeneration (AMD). In addition, biologically active agents capable of inhibiting HtrA1 activity are provided, and methods of treating diseases and pathological conditions of the eye are additionally disclosed. | 07-01-2010 |
| 20100130722 | POLYMERIC CARRIER FOR DELIVERY OF SMALL INTERFERING RNA - A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed. | 05-27-2010 |
| 20100129358 | METHOD OF DETECTING OCULAR DISEASES AND PATHOLOGIC CONDITIONS AND TREATMENT OF SAME - Ocular diseases affecting the macula or the vasculature of the eye affect a wide variety of individuals. In particular, Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a significant genetic predisposition. Methods of analyzing one or more mutations in the HtrA1 gene in order to identify individuals with a presusceptability to development of an ocular disease and a pathologic condition of the eye and diagnose those currently suffering from an ocular disease or a pathologic condition of the eye are provided. The methods of the present invention may further include analysis of the CFH gene in order to identify individuals with a presusceptability to development of an ocular disease and a pathologic condition of the eye and diagnose those currently suffering from an ocular disease or a pathologic condition of the eye. Compositions and methods for treating ocular disease and pathologic conditions of the eye are also provided. | 05-27-2010 |
| 20100120923 | ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF - Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions. | 05-13-2010 |
| 20100107519 | PERFORATED PLATE SEISMIC DAMPER - Disclosed are apparatus and systems for absorbing seismic energy through non-linear yielding as a structure experiences lateral displacement. A seismic damper according to embodiments of the present invention includes at least one flat plate which can be perforated to include a plurality of apertures and/or cut-outs. One or more interior apertures are formed in the plate, and cut-outs may be formed along outer edges. External nodes are defined between the apertures and the cut-outs and stresses focus on the nodes to reduce non-linear displacement of a brace system to which the seismic damper is attached. One or more tension straps can be attached to the flat plate. Tension straps can be rotated relative to each other. Multiple tension straps may also be on the same surface. Multiple tension straps on the same surface may be nested and parallel. | 05-06-2010 |
| 20100099845 | PROTECTED ENANTIOPURE TRIFLUOROTHREONINES AND METHODS OF MAKING AND USING SAME - Disclosed are processes for preparing a protected trifluorothreonine, or salt thereof or carboxylate derivative thereof, the process comprising: dihydroxylation of an alkene to yield a dihydroxyl compound; conversion of the dihydroxyl compound to a monohydroxyl compound; protection of the monohydroxyl compound to yield an azide compound; transformation of the azide compound to yield an amino compound; protection of the amino compound to yield a protected amine compound; and oxidation of the protected amine compound to yield the protected trifluorothreonine. Also disclosed are compounds having the structure: | 04-22-2010 |
| 20100093620 | TYROSINE-RICH CONOPEPTIDES - The invention relates to relatively short peptides (termed Conopeptide-Y family peptides or CPY family peptides or CPY peptides herein), about 30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which are rich in the amino acid tyrosine. | 04-15-2010 |
| 20100074897 | Methods and Compositions related to HIF-1 alpha - Disclosed are compositions and methods related to HIF-1α. | 03-25-2010 |
| 20100069301 | COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY - Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical compositions are included in the compositions described herein. The compositions described herein are useful in, for example, methods of inhibiting vascular permeability and pathologic angiogenesis, including methods of inhibiting vascular permeability and pathologic angiogenesis induced by specific angiogenic, permeability and inflammatory factors, such as, for example VEGF, bFGF and thrombin. Methods for treating specific diseases and conditions are also provided herein. | 03-18-2010 |
| 20100056844 | BRACHYTHERAPY SEED WITH FAST DISSOLVING MATRIX FOR OPTIMAL DELIVERY OF RADIONUCLIDES TO CANCER TISSUE - A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the microspheres from the polymer matrix. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding or minimizing undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method. | 03-04-2010 |
| 20100049057 | IMAGING OF MACULAR PIGMENT DISTRIBUTIONS - Macular pigments are measured by spectrally selective lipofuscin detection. Light from a light source that emits light at a selected range of wavelengths that overlap the absorption band of macular carotenoids is directed onto macular tissue of an eye for which macular pigment levels are to be measured. Emitted light is then collected from the macular tissue. The collected light is filtered so that the collected light includes lipofuscin emission from the macular tissue at an excitation wavelength that lies outside the macular pigment absorption range and outside the excitation range of interfering fluorophores. The collected light is quantified at each of a plurality of locations in the macular tissue and the macular pigment levels in the macular tissue are determined from the differing lipofuscin emission intensities in the macula and peripheral retina. | 02-25-2010 |
| 20100048714 | Methods and Compositions Related to Inhibition of Ceramide Synthesis - Disclosed are compositions and methods related to the ceramide synthesis pathway and various diseases and disorders associated therewith, such as insulin resistance and inflammation. | 02-25-2010 |
| 20100040622 | NETRIN-RELATED COMPOSITIONS AND USES - The present invention provides methods and compositions for modulating proliferation, differentiation, migration, and adhesion of cardiovascular cell types. | 02-18-2010 |
| 20100035746 | Methods for Making Carbide-Metal Nanocomposite Powders - This chemical vapor synthesis process was designed so that a metal carbide precursor and a secondary metal precursor are separately or together fed into each evaporator in a reactor by specially designed precursor feeders, either simultaneously or sequentially. The reduction and carburization of the vaporized precursors by gaseous mixtures produces carbide-metal nanocomposite powders. The product can be a very uniform mixture of the constituent powders or a uniform agglomerate, which is important to ensure a high quality of bulk cemented metal carbide product after consolidation and sintering. These nanocomposite powders can be readily characterized using XRD, carbon analyzer and TEM. | 02-11-2010 |
| 20100032171 | Supercritical Pentane as an Extractant for Oil Shale - The present invention is directed to methods of extracting a hydrocarbon-based product from subsurface (oil) shale formations, wherein such methods rely on the use of an extraction fluid comprising pentane for facilitating the production of a mobile hydrocarbon-based product when the pentane contacts hydrocarbons in subsurface shale. The contacting process, and the subsequent process of recovering the mobile hydrocarbon-based product, is further enhanced by the methods of fracturing and/or rubblizing portions of the shale formation, so as to enhance their fluid permeability. | 02-11-2010 |
| 20100025263 | NANOPORE PARTICLE ANALYZER, METHOD OF PREPARATION AND USE THEREOF - Provided are the preparation, characterization, and application of a nanopore membrane device. The nanopore device comprises a thin membrane prepared from glass, fused silica, ceramics or quartz, containing one or more nanopores ranging from about 2 nm to about 500 nm. The nanopore is prepared by a template method using sharpened metal wires and the size of the pore opening can be controlled during fabrication by an electrical feedback circuit. The nanopore device is particularly useful for counting and analyzing nanoparticles of radius less than 400 nm. | 02-04-2010 |
| 20100010067 | ARGININE-CONJUGATED BIOREDUCIBLE POLY(DISULFIDE AMINE) POLYMERS FOR GENE DELIVERY SYSTEM - An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with siRNA. ABP is biodegraded under reducing conditions, such as in the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity. ABP is an effective delivery vehicle for gene silencing with siRNA and may be used for treating cancer. | 01-14-2010 |
| 20100009926 | PH-SENSITIVE POLYMERIC MICELLES FOR DRUG DELIVERY - Mixed micelles containing poly(L-histidine-co-phenylalanine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed. | 01-14-2010 |
| 20100004316 | MULTIFUNCTIONAL CARRIERS FOR THE DELIVERY OF NUCLEIC ACIDS AND METHODS OF USE THEREOF - Described herein are multifunctional compounds useful as devices for the delivery of nucleic acids to cells. Also described herein are methods for using the multifunctional compounds. | 01-07-2010 |
| 20100001730 | ENHANCED FILL-FACTOR NMR COILS AND ASSOCIATED METHODS - An NMR probe which includes a probe matrix ( | 01-07-2010 |
| 20090311171 | Hydrogen Storage in a Combined MxAlH6/M'y(NH2)z System and Methods of Making and Using the Same - As a promising clean fuel for vehicles, hydrogen can be used for propulsion, either directly or in fuel cells. Hydrogen storage compositions having high storage capacity, good dehydrogenation kinetics, and hydrogen release and uptake reactions which are reversible are disclosed and described. Generally a hydrogen storage composition of a metal aluminum hexahydride and a metal amide can be used. A combined system (Li | 12-17-2009 |
| 20090299640 | Methods and Compositions Involving Intrinsic Genes - Disclosed are compositions and methods related intrinsic gene sets and methods and compositions related to detecting and classifying cancer. | 12-03-2009 |
| 20090295119 | Wheelchair advantage mobility system - A wheelchair propulsion and braking system ( | 12-03-2009 |
| 20090283425 | Microelectrode Array System With Integrated Reference Microelectrodes To Reduce Detected Electrical Noise And Improve Selectivity Of Activation - A microelectrode array system used to sense physiological signals and stimulate physiological tissue to form signals is disclosed. The array includes a dielectric substrate and a two dimensional array of signal microelectrodes substantially perpendicular to and integrated on the dielectric substrate. At least one reference microelectrode is located adjacent to and integrated with the signal microelectrodes on the dielectric substrate. The reference microelectrodes are positioned on the dielectric substrate relative to the signal microelectrodes to enable a reduced level of electrical noise to be detected between the reference microelectrodes and the recording microelectrodes. | 11-19-2009 |
| 20090274753 | PH-SENSITIVE POLYMERIC MICELLES FOR DRUG DELIVERY - Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed. | 11-05-2009 |
| 20090264354 | Penumbra Nucleic Acid Molecules, Proteins and Uses Thereof - The present invention relates to murine and human Penumbra (for proerythroblast nu[new] Membrane) nucleic acid molecules, proteins and the uses thereof. The invention further relates to the use of Penumbra molecules for the detection of 7q31q32-related deletions, including such deletions associated with myeloid malignancies, particularly detection by hybridization using Penumbra-based probes. | 10-22-2009 |
| 20090259020 | HIGHLY FLUORINATED BETA-AMINO ACIDS AND METHODS OF MAKING AND USING SAME - Disclosed are compounds having the structure: | 10-15-2009 |
| 20090233365 | ARGININE-CONJUGATED BIOREDUCIBLE POLY(DISULFIDE AMINE) POLYMERS FOR GENE DELIVERY SYSTEMS - An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with plasmid DNA. ABP is biodegraded under reducing conditions, such as the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity. | 09-17-2009 |
| 20090215172 | Methods and Compositions Related to Cyclic Peptide Synthesis - Disclosed are compositions and methods for cyclization of polymers such as peptides. | 08-27-2009 |
| 20090203616 | METHODS FOR TREATING PAIN AND SCREENING ANALGESIC COMPOUNDS - The present invention relates to the use of compounds that block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) for treating pain, such as neuropathic pain and inflammatory pain, and inflammatory disorders, such as arthritis. The present invention also relates to screening compounds to identify analgesic agents that block the α9α10 subtype of the nAChR. | 08-13-2009 |
| 20090142842 | CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY(AMIDO ETHYLENIMINE)S TO ENHANCE NUCLEOTIDE DELIVERY - Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly(triethyenetetramine/cystamine bisacrylamide) copolymer (poly(TETA/CBA)). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly(TETA/CBA)-PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid. | 06-04-2009 |
| 20090130752 | BIODEGRADABLE POLY(DISULFIDE AMINE)S FOR GENE DELIVERY - Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(CBA-DAE), poly(CBA-DAB), and poly(CBA-DAH). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and N-Boc-protected diamine monomers, followed by N-Boc deprotection. Complexes are formed by mixing the poly(disulfide amine)s with nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes. | 05-21-2009 |
| 20090117570 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 05-07-2009 |
| 20090117569 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 05-07-2009 |
| 20090117568 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 05-07-2009 |
| 20090117567 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 05-07-2009 |
| 20090117553 | NUCLEIC ACID MELTING ANALYSIS WITH SATURATION DYES - Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided. | 05-07-2009 |
| 20090117078 | CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF - Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) die oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one thiol compound with at least one thiol-reactive compound. | 05-07-2009 |
| 20090105193 | CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF - Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) the oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one thiol compound with at least one thiol-reactive compound. | 04-23-2009 |
| 20090104608 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 04-23-2009 |
| 20090104607 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 04-23-2009 |
| 20090104143 | Hyaluronic acid containing bioconjugates: targeted delivery of anti-cancer drugs to cancer cells - A cell-targeted polymeric drug delivery system was designed based on the specific interaction between hyaluronic acid (HA) and its cell surface receptors overexpressed on cancer cell surface. The invention relates to compounds composed of a carrier molecule, wherein the carrier molecule contains at least one residue of an anti-cancer agent and at least one residue of a hyaluronic acid. The invention also relates to methods of making and using the compounds thereof. | 04-23-2009 |
| 20090075280 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 03-19-2009 |
| 20090042869 | SIGNAL-DEPENDENT SPLICING OF TISSUE FACTOR PRE-mRNA IN PLATELET CELLS - The invention relates to therapeutic target recognition, development, and validation of a compound capable of directly or indirectly modulating TF pre-mRNA splicing in a platelet cell and the use of a platelet TF pre-mRNA splicing modulator for the treatment of a subject suffering from, or thought to be suffering from, disordered coagulation. | 02-12-2009 |
| 20090011403 | MICROPOROUS MATERIALS, METHODS OF MAKING, USING, AND ARTICLES THEREOF - Described herein are methods for separating one or more analytes present in a fluid sample. The methods involve passing the fluid through or into a microporous material, wherein the analytes are localized near the surface of the microporous material. Additional processing steps such as hybridization and amplification can be performed once the analyte is localized. In one method, once the analyte is localized, the analyte can be detected, counted, and correlated in order to determine the concentration of the analyte in the sample. In another method, the localized analyte is destabilized to make the localized analyte more accessible for chemical manipulation. Modified microporous materials and composite materials are also disclosed that can be used in any of the methods and articles described herein. The composite is composed of a microporous material and a pigment, wherein the pigment is incorporated in the microporous material. The pigments alter the optical properties of the microporous material, which enhances the detection of analyte once it is localized. Methods for making pigmented composites are also disclosed. In a further aspect, various kits and articles such as filtration devices containing any of the microporous materials described herein are provided. | 01-08-2009 |
| 20090005820 | Antimicrobial Containment Cap For a Bone Anchored Prosthesis Mounting - An antimicrobial containment cap is provided for use in a bone anchored prosthesis mounting system of the type having an externally protruding fixator pin carried by all implanted bone anchored mounting post, wherein the fixator pin accommodates removable attachment to an exoskeletal prosthesis such as a prosthetic limb or the like for an amputee. The containment cap, when mounted onto the fixator pin, is interposed between the prosthesis and soft tissue covering the end or stump of an amputated residual limb or the like. The containment cap carries and supports a selected antimicrobial or antibacterial agent in substantial contact with the soft stump tissue in a position closely overlying and substantially circumscribing the tissue interface with the externally protruding fixator pin to safeguard against infection. The containment cap is adapted for quick and easy periodic removal for cleaning and/or replenishment of the antimicrobial agent. | 01-01-2009 |
| 20080300201 | Cell Cycle Arrest and Apoptosis - The HIV-1 accessory gene vpr encodes a conserved 96-amino acid protein that is necessary and sufficient for the HIV-1-induced block of cellular proliferation and induction of apoptosis. Expression of vpr in CD4 | 12-04-2008 |
| 20080299527 | Method and System for Supporting and Enhancing Time Management Skills - A method and system for supporting and enhancing time management skills. Through the use of an electronic time management device, such as a cell phone or other portable digital computer based device programmed to support this method, the user enters information about a task which is then verified and “banked points” are given for correct entry. The banked points can then be used toward a socially desirable reward, such as sending text messages or playing music or watching videos. This is particularly effective in teaching time management skills to young students who may have attention deficit hyperactivity disorder (ADHD). | 12-04-2008 |
| 20080288087 | Releasible Attachment System For a Prosthetic Limb - A releasable attachment system is provided for use with a bone anchored post and related external prosthesis such as a prosthetic limb or the like, wherein the attachment system includes a safety release mechanism designed to release or break away when encountering an excess mechanical load. The bone anchored mounting post is implanted for direct affixation to patient bone, and carries or is connected to a fixator structure protruding through soft skin tissue and the like at the end or stump of an amputated limb for mechanical connection to the external prosthesis. The safety release mechanism accommodates substantially normal patient movement throughout a corresponding range of substantially normal mechanical loads, but releases in the presence of an excess load to prevent undesirable fracture failures. | 11-20-2008 |
| 20080276327 | Methods and Compositions Related to Delivery of Chemical Compounds to Invertebrate Embryos - Disclosed are methods and compositions related to the delivery of chemical compounds to invertebrate embryos. | 11-06-2008 |
| 20080274976 | USES OF NOVEL POTASSIUM CHANNEL BLOCKERS - The present invention is directed to kappaM (κM) conopeptide RIIIK and its use for blocking the flow of potassium ions through voltage-gated potassium channels. The κM conopeptides include unglycosylated and O-glycosylated peptides. | 11-06-2008 |
| 20080271389 | PERFORATED PLATE SEISMIC DAMPER - The present invention relates to apparatus and systems for absorbing seismic energy to prevent non-linear displacement in a structure. A seismic damper according to embodiments of the present invention includes at least one flat plate which can be perforated to include a plurality of apertures and/or cut-outs. Interior apertures are formed in the flat plate, and one or more cut-outs along outer edges. Nodes are defined between the apertures and the cut-outs and stresses from transferred energy focus on the nodes to reduce non-linear displacement of a brace system to which the seismic damper is attached. One or more tension straps can be attached to the flat plate. The interior apertures may include a single aperture, or multiple apertures. The apertures may include slots. Two plates may be connected and rotated relative to each other placing the apertures out of alignment. Tension straps can be rotated relative to each other. | 11-06-2008 |
| 20080262186 | Catalysts for the Production of Polyisocyanates - Disclosed is a method for making oligomeric and polymeric isocyanates, particularly uretdiones and isocyanurates, by reacting diisocyanates in the presence of a catalyst, wherein the catalyst comprises either free N-heterocyclic carbenes, imidazolylidene carboxylates, triazolylidene carboxylates, or salts thereof. | 10-23-2008 |
| 20080227738 | Compositions and methods for cell dedifferentiation and tissue regeneration - The present invention provides methods and compositions to dedifferentiate a cell. The ability of the methods and compositions of the present invention to promote the dedifferentiation of differentiated cells, including terminally differentiated cells, can be used to promote regeneration of tissues and organs in vivo. The ability of the methods and compositions of the present invention to promote the dedifferentiation of differentiated cells, including terminally differentiated cells, can further be used to produce populations of stem or progenitor cells which can be used to promote regeneration of tissues and/or organs damaged by injury or disease. Accordingly, the present invention provides novel methods for the treatment of a wide range of injuries and diseases that affect many diverse cell types. | 09-18-2008 |
| 20080220430 | Methods for assessing risk for cardiac dysrythmia in a human subject - The present invention relates to methods for assessing the risk of a patient for developing a potentially fatal cardiac dysrhythmia and for diagnosing Andersen's Syndrome. A tissue sample from a patient is obtained and the DNA or proteins of the sample isolated. From the DNA and protein isolates the sequence of the KCNJ2 gene or the Kir2.1 polypeptide can be obtained. The KCNJ2 gene or the Kir2.1 can be screened for alteration as compared to the wile-type sequence. An alteration in a copy of the KCNJ2 gene or a Kir2.1 polypeptide indicates that the patient has a high risk for developing a cardiac dysrhythmia and can be diagnosed with Andersen's Syndrome. The invention also related to isolated nucleic acid molecules with one or more alterations as compared to the wild-type sequence. | 09-11-2008 |
| 20080218184 | NANOPORE PLATFORMS FOR ION CHANNEL RECORDINGS AND SINGLE MOLECULE DETECTION AND ANALYSIS - Chemical modification of a glass and fused silica nanopore surfaces results in surface properties that are ideal for localized bilayer formation over a nanopore and subsequent ion channel recording. With no surface modification, one may form a bilayer supported on the glass capillary extending across the nanopore orifice. Changing the surface properties from that of bare glass to a moderately hydrophobic surface produces a lipid monolayer above the glass and spontaneously yields a bilayer across the nanopore orifice, effectively corralling a single protein ion channel in the lipid bilayer region spanning nanopore orifice. The bilayer structure over the modified nanopore is such that current can only flow through the protein ion channel. The protein ion channel is able to diffuse in the bilayer above the pore opening, but cannot leave this area to enter the lipid monolayer. The bilayer formed across the nanopore orifice exhibits high electrical breakdown voltage, is stable to mechanical vibrations, and is long lived. Resistance through the protein channel can be measured electrically and is exploited for stochastic single-molecule detection. Protein ion channels can be inserted and removed from the bilayer by adjusting transmembrane pressure, and adapter molecules can be electrostatically trapped in the ion channel by applying high transmembrane voltages. | 09-11-2008 |
