UNIVERSITY OF TSUKUBA Patent applications |
Patent application number | Title | Published |
20150368658 | AGROBACTERIUM HAVING HIGHLY EFFICIENT GENE TRANSFER ABILITY TO PLANT IMPARTED THERETO - The present invention relates to an | 12-24-2015 |
20150313994 | SURFACE-MODIFIED IRON OXIDE PARTICLES FOR CANCER ABLATION - An object of the present invention is to provide surface-modified ferromagnetic iron oxide particles suitable for electromagnetic-induction cancer ablation, which have excellent heat generation properties and also have excellent dispersion stability in a medium for injection. The surface-modified iron oxide particles for cancer ablation of the present invention as a means for achieving the object are characterized in that a block copolymer of polyethylene glycol and polystyrene having a phosphorous acid group in the side chain is bound to the surface of ferromagnetic iron oxide particles having a plate-like shape with a length of 20 to 200 nm and a length-to-thickness ratio of 1.5 to 30 and having magnetic properties such that the coercivity is 30 to 300 Oe, the saturation magnetization is 20 to 80 emu/g, and the squareness ratio of the magnetic hysteresis loop is 0.20 to 0.50. | 11-05-2015 |
20150299332 | MEDICAMENT COMPRISING ACTIVITY MODULATOR FOR CD300a-EXPRESSING CELL ASSOCIATED WITH ALLERGIC DISEASE, CD300a GENE-DEFICIENT MOUSE, AND USE OF ACTIVITY MODULATOR FOR CD300a-EXPRESSING CELL - The present invention provides medicaments for allergic diseases (atopic dermatitis, asthma, and the like), and a tool useful for pathology analysis of allergic diseases. A medicament containing as an effective component an activity modulator for suppressing inhibitory signal transduction of a CD300a-expressing myeloid cell, which activity modulator contains a substance that inhibits binding of CD300a to phosphatidyl serine, can be used for treatment or prophylaxis of an allergic disease. A CD300a gene-deficient mouse can be used as a model mouse in which the allergic disease is hardly induced after administration of a substance that induces the allergic disease, which may be used for carrying out pathology analysis of an allergic disease, or for screening of a possible candidate substance for an effective component of a therapeutic agent or prophylactic agent for the disease. | 10-22-2015 |
20150238622 | BORON CLUSTER-MODIFIED PEG LIPID DERIVATIVE, AND MOLECULAR ASSEMBLY USING SAME - The present invention provides a novel boron carrier compound that can be used for boron neutron capture therapy for cancer, and that can realize improvement in the efficiency of a Drug Delivery System (DDS) and an increase in the boron concentration in a tumor. The present invention provides a boron cluster-modified PEG lipid derivative represented by Formula (I): | 08-27-2015 |
20150150747 | WEARABLE ACTION-ASSIST DEVICE AND CONTROL PROGRAM - A wearable action-assist device includes a biosignal detection unit detecting a biosignal from a wearer, an action-assist wearing tool having a drive source supplying a torque acting on the wearer around each joint of the wearer as an axis of rotation, a control unit controlling the drive source to generate the torque according to the detected biosignal, a drive torque estimation unit estimating a drive torque generated by the drive source, a joint-angle detecting unit detecting an angular displacement of the joint, and a parameter identification unit identifying kinetics parameters concerned by substituting the estimated drive torque and the detected angular displacement into an equation of motion of an entire system including kinetics parameters intrinsic to the wearer. The control unit is configured to control the drive source according to a predetermined control method based on the equation of motion into which the identified parameters are substituted. | 06-04-2015 |
20150047059 | ACTIVITY MODULATOR, MEDICINAL AGENT COMPRISING SAME, USE OF CD300A GENE-DEFICIENT MOUSE, AND ANTI-CD300A ANTIBODY - The present invention aims to provide: an immunostimulant useful for maintaining, enhancing or suppressing an immune function associated with CD300a activation signaling, or an immunomodulator as an immunosuppressant useful for suppressing the immune function; use of a CD300a gene-deficient mouse for pathology analysis and the like; an anti-CD300a antibody; and the like. | 02-12-2015 |
20150045449 | METHOD FOR ISOLATING POLYPHENOLS FROM OLIVE MILL WATER - The present invention relate to a highly efficient and novel method, using clean technologies, for obtaining a natural bioactive concentrate that is rich on polyphenols from olive mill water (OMW). The clean technologies integrate centrifugation, a drowning-out crystallization-based separation process, and vacuum evaporation. The method provides a highly-concentrated polyphenol isolate (up to 99% (mass fraction)) from other components presents in OMW, with up to half of the polyphenol content being hydroxytyrosol. The isolated polyphenols exhibit anti-oxidant, anti-microbial, anti-inflammatory, and anti-carcinogenic activities; they can be prepared as solid particles, as an aqueous solution, in an emulsion, or as lipidic-based nanoparticles. The isolated polyphenols can be used in the food industry, cosmetic industry, or pharmaceutical industry. | 02-12-2015 |
20150009507 | SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY AND METHOD FOR STABILIZING PHASE THEREOF - In an embodiment, a computer | 01-08-2015 |
20140364755 | DIAGNOSTIC APPARATUS - A diagnostic apparatus includes a stethoscope, an electrocardiac detector, a control unit, and an external unit. A sound detector is a chest piece to make contact with a patient's skin, and includes a first detector to detect a relatively high frequency and a second detector to detect a relatively low frequency. The electrocardiac detector includes electrodes to detect potentials associated with heart beats, and is provided on each of the first and second detectors. The control unit converts electrocardiac signals detected by the electrocardiac detector into radio signals that are transmitted to the external unit. The external unit is a portable terminal apparatus, and includes a display unit formed by a liquid crystal panel on a front surface thereof, an operation part including operation buttons and ten-key, and patient selection buttons to select reading of data of patients. | 12-11-2014 |
20140318335 | STEEL-STRUCTURE DEMOLITION METHOD - A steel-structure demolition method for demolishing a steel structure by causing the steel structure to collapse, the steel-structure demolition method includes: demolishing the steel structure in such a fashion that the steel structure is cut along a cutting line extending in a direction perpendicular to a depth direction thereof when having collapsed. | 10-30-2014 |
20140271335 | SUPER ELASTIC ZIRCONIUM ALLOY FOR BIOLOGICAL USE, MEDICAL INSTRUMENT AND GLASSES - Provided is a super elastic alloy for biological use having a high biocompatibility, good processability and super elasticity, said super elastic alloy being a super elastic zirconium alloy for biological use comprising 27-54 mol % inclusive of titanium, 5-9 mol % inclusive of niobium which is a β phase-stabilizing element capable of stabilizing the β phase of zirconium, and 1-4 mol % inclusive in total of tin and/or aluminum which are ω phase-suppressing elements capable of suppressing the ω phase of zirconium, with the balance consisting of zirconium and inevitable impurities. | 09-18-2014 |
20140163434 | MOTION-ASSIST SYSTEM OF WEARABLE MOTION-ASSIST DEVICE, WEARABLE MOTION-ASSIST DEVICE, AND MOTION-ASSIST METHOD OF WEARABLE MOTION-ASSIST DEVICE - A motion state of a wearable motion-assist device of a doctor is sent to the wearable motion-assist device of a patient via a network. Then, this motion state is applied to the wearable motion-assist device of the patient, so that rehabilitation is conducted for the patient. Furthermore, the motion state of the wearable motion-assist device of the patient is sent from the wearable motion-assist device to the wearable motion-assist device. Then, the motion state of the wearable motion-assist device is applied to the wearable motion-assist device. Accordingly, the doctor can objectively sense the state of the patient. | 06-12-2014 |
20140148399 | Compositions and methods for treating or ameliorating obesity or for reducing diabetic hypercholesterolemia - Obesity is one of the major health concerns in the Twenty-First Century and is one of the leading causes of preventable death. It is a strong risk factor for Type 2 Diabetes. Disclosed herein are compositions and methods using | 05-29-2014 |
20140147848 | COMPOSITIONS AND METHODS FOR LINEAR ALKYLBENZENE SULFONATE (LAS) RISK ASSESSMENT - The present disclosure provides a method for assessing the environmental effects of alkylbenzenesulfonate (LAS). For example, the method includes contacting a population of cells with a sample, measuring an expression level of one or more LAS biomarkers in the cell population, comparing the level of expression of the one or more LAS biomarker to one or more reference values corresponding to the one or more LAS biomarkers, and determining an LAS risk associated with the sample. | 05-29-2014 |
20140115022 | PROGRAM FOR CORRECTING DATA MEASURED BY PS-OCT AND PS-OCT SYSTEM EQUIPPED WITH THE PROGRAM - Data measured by PS-OCT is corrected in a non-linear manner to enhance the quantitative analysis capability of PS-OCT and permit accurate quantitative diagnosis, including diagnosis of disease stage of lesions, as a useful means for computer diagnosis. Even when retardation per PS-OCT | 04-24-2014 |
20140020134 | FRUIT-SPECIFIC PROMOTER - The present invention relates to a fruit-specific promoter, which is suitable for the expression in a broader range of developmental stages of a fruit. Provided is a fruit-specific promoter DNA, which consists of a nucleotide sequence having 85% or more identity with the nucleotide sequence as shown in SEQ ID NO: 1 or 2 and has promoter activity in mature-green fruits. | 01-16-2014 |
20130342965 | CARBON NANOSTRUCTURE, CAPACITOR, METHOD FOR PROCESSING CARBON NANOSTRUCTURE, AND METHOD FOR PRODUCING CARBON NANOSTRUCTURE - A carbon nanostructure's geometry and electrical characteristics can be controlled. A method for processing a carbon nanostructure according to the present invention includes the steps of: preparing a carbon nanostructure (e.g., a carbon nanotube) (a CNT preparation step); and exposing the carbon nanotube to an energy beam (e.g., an electron beam) while vibrating the carbon nanotube (an exposure step). This facilitates modifying the carbon nanotube in length and electrical characteristics. | 12-26-2013 |
20130321565 | COMMUNICATION WALL PANEL, NURSING CARE SYSTEM HAVING COMMUNICATION WALL PANEL, AND CONFERENCE SYSTEM HAVING COMMUNICATION WALL PANEL - A communication wall panel includes an interior panel member to be attached to a room as an interior wall material thereof; an information obtaining part provided in the interior panel member and configured to obtain information associated with a person in the room; a notification part provided in the interior panel member and configured to notify the person in the room of information; a communication part provided in the interior panel member and configured to perform communication with a server installed in a location other than the room; and a control part provided in the interior panel member and configured to control the information obtaining part and the notification part. The communication part is configured to transmit information obtained from the information obtaining part to the server and to output information transmitted from the server to the notification part. | 12-05-2013 |
20130288327 | Novel Microorganism Having High Squalene-Producing Ability, and Method For Producing Squalene by Means of Same - Provided is a strain belonging to the genus | 10-31-2013 |
20130253657 | METHOD FOR PRODUCING IMPLANT MATERIAL - The production method of an implant material of the present invention includes
| 09-26-2013 |
20130252304 | NOVEL STRAIN CLASSIFIED UNDER Botryococcus braunii - Provision of a novel strain belonging to | 09-26-2013 |
20130171712 | CULTURE METHOD AND CULTURE DEVICE - Provided are a culture method and a culture device for efficiently producing cells and/or cell tissue suitable for medication applications. A culture method of culturing cells adhered onto an electrode layer, the method including: a first step of adhering the cells onto the electrode layer and culturing the cells thereon, the electrode layer being coated with an oligopeptide including: a terminal amino acid; a cell adhesive sequence; and an alternating sequence to be bound to the one end side of the cell-adhesive sequence, the alternating sequence including a plurality of acidic amino acids and a plurality of basic amino acids, being alternately bound to each other one by one; and a second step of applying, to the electrode layer having the cells adhered thereonto, an electrical potential inducing reductive desorption of the oligopeptide, to thereby detach the cells from the electrode layer. | 07-04-2013 |
20120329978 | POLYMER DYE - A polymer dye has repeating units of formula (I): | 12-27-2012 |
20120256104 | PHASE CHANGE DEVICE HAVING PHASE CHANGE RECORDING FILM, AND PHASE CHANGE SWITCHING METHOD FOR PHASE CHANGE RECORDING FILM - Allow the rate of phase change to be controlled at the time period of phonons (approx. 270 fs) for the purpose of achieving a substantially higher recording-erasing speed compared to what can be achieved with conventional technologies relating to optical recording media using phase change. A femtosecond pulse laser is shaped into pulse trains each having a first pulse and a second pulse using a Michelson interferometer, and the time interval of first and second pulses is matched with the time period of lattice vibration of a material constituting the phase change recording film to be irradiated, thereby inducing phase change. | 10-11-2012 |
20120219452 | COPPER ALLOY AND COPPER ALLOY MANUFACTURING METHOD - A copper alloy having an electrical resistivity lower than those of current copper alloys and a tensile strength higher than those of current copper alloys and a method of manufacturing such a copper alloy are provided. | 08-30-2012 |
20120209134 | CLASSIFICATION ESTIMATING SYSTEM AND CLASSIFICATION ESTIMATING PROGRAM - A classification estimating system can include an input element group; an intermediate element group into which are input values of first intermediate variables for which a first multiple desensitization, including an accumulation of values of each input element of a first input element group and each value of a first output sensitivity and each value of a first multiplex output sensitivity, has been carried out and calculated; an output element group into which is input a value of an output variable calculated based on a value of each intermediate element of a first intermediate element group and a value of each connection weight; a classification information estimating module for estimating classification information based on pre-stored correspondence relationship information and a value of the output variable; and a classification information display. | 08-16-2012 |
20120120408 | TWO-BEAM OPTICAL COHERENCE TOMOGRAPHY APPARATUS - The scanning speed of a sample in Doppler OCT, etc., is increased to enable quick measurement of blood flow rate, blood flow volume, etc. Wideband light from a light source | 05-17-2012 |
20120065089 | Method For Detecting And Distinguishing Intrahepatic Cholangiocarcinoma - Disclosed are a method for early, sensitively and reliably detecting and distinguishing intrahepatic cholangiocarcinoma in a malignant tumor occurring primarily in the liver in a simple way, and a kit therefor. In the method, a glycan biomarker consisting of a lectin WFA (Wisteria floribunda Agglutinin)-binding glycoprotein derived from intrahepatic cholangiocarcinoma is used as a cancer marker to detect intrahepatic cholangiocarcinoma by detecting the cancer marker in a test specimen. The method for detecting intrahepatic cholangiocarcinoma can clearly differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma and enables early detection and determination with a performance clinically acceptable in terms of applicability, sensitivity and precision. | 03-15-2012 |
20110318762 | Graft-Versus-Host Disease Predicting Marker and Use Thereof - A test method that provides data useful in predicting the probability of onset of acute graft-versus-host disease (GVHD) is described along with a kit for performing the method, and a pharmaceutical preparation and a molecular targeted therapy for treating or preventing GVHD. The test method includes measuring the blood DNAM-1 concentration of a patient of hematopoietic stem cell transplantation from bone marrow or the like over a period after the transplantation to provide data concerning the transition of the concentration to an abnormally high level deviating from the normal range, whereby the probability of the development of acute graft-versus-host disease is predicted, the risk of the development is estimated, or therapeutic effects after the development are evaluated. Concerning the molecular targeted therapy and pharmaceutical preparation used therefor wherein blood DNAM-1 of a GVHD patient or a graft recipient that is a possible patient is used as a target molecule, GVHD is treated or prevented by administering an anti-DNAM-1 antibody that is a neutralizing antibody. | 12-29-2011 |
20110262944 | CONSTRUCTION AND CRYSTALLIZATION OF EXPRESSION SYSTEM FOR RNA POLYMERASE PB1-PB2 PROTEIN DERIVED FROM INFLUENZA VIRUS - The present invention aims to express influenza virus RNA polymerase on a large scale, to crystallize the influenza virus RNA polymerase, and to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs. | 10-27-2011 |
20110249797 | RADIATION TREATMENT SYSTEM - A radiation treatment system that can apply radiation to a respiratory moving organ (such as, a lung, a liver or the like) with high precision is provided. A radiation treatment system according to the present invention as solving means is characterized in that when medical treatment target position information obtained by executing pattern matching processing on the inside of each frame of a fluoroscopic X-ray image for detecting a medical treatment target position achieved under medical treatment on the basis of a template image of an area containing a medical treatment target position of a patient, which is achieved in advance, is within a predetermined error range with respect to the medical treatment target position information based on the template image, and also a timing is an application timing of medical treatment radiation which is set on the basis of motion information of a body surface, a signal for applying medical treatment radiation is generated; and in the other cases, a signal for stopping the application is generated, whereby the application of the medical treatment radiation is controlled on the basis of these signals. | 10-13-2011 |
20110187812 | COMMUNICATION WALL PANEL, NURSING CARE SYSTEM HAVING COMMUNICATION WALL PANEL, AND CONFERENCE SYSTEM HAVING COMMUNICATION WALL PANEL - A communication wall panel includes an interior panel member to be attached to a room as an interior wall material thereof; an information obtaining part provided in the interior panel member and configured to obtain information associated with a person in the room; a notification part provided in the interior panel member and configured to notify the person in the room of information; a communication part provided in the interior panel member and configured to perform communication with a server installed in a location other than the room; and a control part provided in the interior panel member and configured to control the information obtaining part and the notification part. The communication part is configured to transmit information obtained from the information obtaining part to the server and to output information transmitted from the server to the notification part. | 08-04-2011 |
20110166491 | BIOLOGICAL SIGNAL MEASURING WEARING DEVICE AND WEARABLE MOTION ASSISTING APPARATUS - A biological signal measuring wearing device configured to measure a biological signal from the body surface of a wearer includes a wearing device body configured to cover the body surface of the wearer, multiple biological signal detecting parts provided on a predetermined part of the inner surface of the wearing device body and configured to detect a signal from the body surface of the wearer, a biological signal obtaining part configured to obtain the biological signal from the signal detected by the biological signal detecting parts, and a signal communicating part configured to communicate the biological signal obtained by the biological signal obtaining part to an external apparatus. | 07-07-2011 |
20110162102 | Novel root-knot-nematode-resistance gene and application thereof - This invention relates to an excellent root-knot nematode-resistance gene and a method for using the same. More particularly, this invention relates to a novel root-knot nematode-resistance gene that is unaffected by high temperature and is applicable to and quantitatively resistant to a wide variety of root-knot nematode species and strains and a root-knot nematode-resistant transgenic plant into which such gene has been introduced. | 06-30-2011 |
20110150953 | METHOD FOR PRODUCING VESICLE, VESICLE OBTAINED BY THE PRODUCTION METHOD, AND W/O/W EMULSION FOR PRODUCING VESICLE - A vesicle is produced by: a step of producing a W/O emulsion from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an organic solvent phase containing a lipid having emulsification capacity, which can constitute the vesicle; a step of producing a W/O/W emulsion from the W/O emulsion and an external water phase solution of a water-soluble emulsifier, which does not destroy a vesicle lipid membrane; and a step of removing the organic solvent phase from the W/O/W emulsion, so as to form a vesicle. This method simultaneously achieves a high entrapment yield of an active ingredient and the control of a particle diameter. | 06-23-2011 |
20110125327 | BUILDING MANAGEMENT APPARATUS - A building management apparatus that can provide a comfortable environment based on diligent control is provided. A building management apparatus | 05-26-2011 |
20110118585 | EYEBALL TISSUE CHARACTERISTIC FREQUENCY MEASUREMENT DEVICE AND NON-CONTACT TONOMETER UTILIZING THE SAME - A non-contact tonometer of the present invention quantitatively measures characteristic vibration of the cornea of an eyeball and measures a true ocular pressure utilizing this vibration, and comprises: an air flow spray unit ( | 05-19-2011 |
20110118564 | BLOOD VESSEL CHARACTERISTICS MEASURING APPARATUS AND BLOOD VESSEL CHARACTERISTICS MEASURING METHOD - The blood vessel characteristics measuring apparatus | 05-19-2011 |
20110042237 | ELECTROCHEMICAL SENSOR DEVICE AND ELECTROCHEMICAL MEASURING METHOD USING THE SAME - Provided is an electrochemical sensor device capable of micromachining a channel while maintaining its measurement sensitivity and of reliably quantitating an analyte in a trace amount of a sample. An electrochemical sensor device includes: a channel portion formed in a substrate; and working electrodes for subjecting an analyte in a solution flowing in the channel portion to electrochemical measurement, the electrochemical sensor device includes a plurality of measuring portions individually provided with the working electrodes, and each of the working electrodes has a plurality of conductive protrusion portions formed to protrude from a bottom surface of each of the measuring portions. | 02-24-2011 |
20100304375 | Influenza Virus Genome Replication and Transcription System in Yeast Cells - A system in which vRNP purified from influenza virus particles is introduced into yeast ( | 12-02-2010 |
20100296965 | ALLOY SOLDER AND ALLOY SOLDER MANUFACTURING METHOD - The present invention solves the problem of the bonding strength of a Pb-free alloy solder being inferior to that of the conventional Pb-containing alloy solder and provides a Pb-free alloy solder satisfactory in bonding reliability. | 11-25-2010 |
20100280628 | WEARABLE ACTION-ASSIST DEVICE, AND METHOD AND PROGRAM FOR CONTROLLING WEARABLE ACTION-ASSIST DEVICE - A wearable action-assist device which assists or executes an action of a wearer by substituting for the wearer is provided with an action-assist tool | 11-04-2010 |
20100271051 | CENTROID POSITION DETECTOR DEVICE AND WEARING TYPE ACTION ASSISTANCE DEVICE INCLUDING CENTROID POSITION DETECTOR DEVICE - Load measuring parts | 10-28-2010 |
20100217163 | ROTATION ADJUSTMENT APPARATUS AND METHOD OF CONTROLLING ROTARY APPARATUS - [Problem to be Solved] It is an object of the present invention to reduce energy consumed when a rotary apparatus is used and to suppress abrasion and breakage on the rotary apparatus and a driving apparatus which drives the rotary apparatus. | 08-26-2010 |
20100200073 | FLUID TRANSPORT DEVICE AND FLUID TRANSPORT CONTROL METHOD - A fluid transport device transports fluid containing electrolytes within a flow channel. At least a portion of the inner walls of the flow channels are hydrophilic from the inlet to the outlet thereof except at least one valve portion. The device also includes: the valve portions, which are hydrophobic and function to block transport of at least one fluid; electrodes, which are provided at the at least one valve portion and function to reduce the surface tension of the fluid; and air vents, which are provided at the at least one valve portion and function to introduce air in order to block the fluid. | 08-12-2010 |
20100184267 | METHOD OF FORMING SILICON OXIDE FILM AND METHOD OF PRODUCTION OF SEMICONDUCTOR MEMORY DEVICE USING THIS METHOD - To form a good quality silicon oxide film provided with both a superior Qbd characteristic and Rd characteristic, a wafer W is loaded into a plasma treatment apparatus where the surface of a silicon layer | 07-22-2010 |
20100166840 | LIPOSOME HAVING LIPID MEMBRANE CONTAINING BACTERIAL CELL COMPONENT - The object is to provide a liposome by which a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW) can be pharmaceutically prepared in a form applicable to a living body (i.e., a form in which the bacterial cell component can be dispersed in an aqueous solvent and has a controlled size) without using any surfactant. Disclosed is a liposome having a lipid membrane containing a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW). | 07-01-2010 |
20100146666 | METHOD FOR PRODUCING PLANT WITH MODIFIED FLOWER MORPHOLOGY - A plant with modified flower morphology is produced by suppressing a function of a transcription factor involved in determining the polarity of plants. More particularly, a plant with modified flower morphology is produced by the steps of obtaining a transformed cell by introducing a chimeric DNA in which a DNA encoding a transcription factor involved in determining the polarity and a functional peptide converting a transcription factor into a transcription repressor are fused; and regenerating a transformed plant from the transformed cell. | 06-10-2010 |
20100121232 | MOTION-ASSIST SYSTEM OF WEARABLE MOTION-ASSIST DEVICE, WEARABLE MOTION-ASSIST DEVICE, AND MOTION-ASSIST METHOD OF WEARABLE MOTION-ASSIST DEVICE - In the present invention, the motion state of the wearable motion-assist device | 05-13-2010 |
20100029791 | METHOD FOR PRODUCING VESICLE, VESICLE OBTAINED BY THE PRODUCTION METHOD, AND METHOD FOR PRODUCING FROZEN PARTICLE USED IN PRODUCTION OF VESICLE - A W/O emulsion is produced from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an oil phase containing an emulsifier; subsequently, the W/O emulsion is cooled to a temperature at which the aqueous solution of the W/O emulsion becomes a frozen particle and the oil phase maintains a liquid state, and the oil phase is removed; thereafter, an oil phase containing a vesicle constituent lipid is added to the frozen particle, and the obtained mixture is then stirred, so as to substitute the emulsifier on the surface of the frozen particle with the vesicle constituent lipid; and thereafter, an external water phase is added to the frozen particle coated with a lipid membrane, so as to hydrate the lipid membrane by the external water phase. This process achieves a high entrapment yield of a desired substance while controlling desired physical properties such as particle diameter. | 02-04-2010 |
20090319054 | WEARABLE ACTION-ASSIST DEVICE, AND METHOD AND PROGRAM FOR CONTROLLING WEARABLE ACTION-ASSIST DEVICE - A wearable action-assist device which assists or executes an action of a wearer by substituting for the wearer is provided with an action-assist tool | 12-24-2009 |
20090293161 | CANTILEVER DEVICE AND CANTILEVER CONTROLLING METHOD - The amplitude control of a cantilever based on the van der Pol model is performed through a feedback using the measurement data on a deflection of the cantilever. A self-oscillating circuit integrates a deflection angle signal of a cantilever detected by a deflection angle measuring mechanism using an integrator, multiplies a resulting integral value by linear feedback gain K | 11-26-2009 |
20090275837 | ULTRASONIC MEASUREMENT APPARATUS - A processing unit calculates first displacement related information concerning a first direction of an object to be measured by using data in either one of an increase period and a decrease period of a force applied to the objected to be measured, among first received data received by a first ultrasonic probe. In addition, the processing unit calculates second displacement related information concerning a second direction of the object to be measured by using data in the same period as that used to calculate the first displacement related information, among second received data received by a second ultrasonic probe. | 11-05-2009 |
20090220811 | TITANIUM-TANTALUM BASE SHAPE MEMORY ALLOYS, ACTUATOR AND ENGINE - A Titanium-Tantalum base shape memory alloy is provided which possesses high machinability and is suitable for repeated high temperature operation. The Titanium-Tantalum base shape memory alloy consists of 15 mol %-40 mol % Tantalum, additive elements, and the balance Titanium and impurities. | 09-03-2009 |
20090218013 | HIGH TEMPERATURE SHAPE MEMORY ALLOY, ACTUATOR AND MOTOR - A high temperature shape memory alloy is provided which possesses high machinability and is suitable for high temperature applications. The high temperature shape memory alloy consists of Ni from 34.7 mol % to 48.5 mol %, at least either Zirconium or Hafnium as transformation temperature increasing additives, with the sum of which 6.8 mol % to 22.5 mol %, and at least either Niobium or Tantalum as machinability improving additives, with the sum of which 1 mol % to 30 mol %; and Boron less than 2 mol %; and Titanium as the balance; and unavoidable impurity. | 09-03-2009 |
20090186017 | Graft-Versus-Host Disease Predicting Marker and Use Thereof - A test method that provides data useful in predicting the probability of onset of acute graft-versus-host disease (GVHD) is described along with a kit for performing the method, and a pharmaceutical preparation and a molecular targeted therapy for treating or preventing GVHD. The test method includes measuring the blood DNAM-1 concentration of a patient of hematopoietic stem cell transplantation from bone marrow or the like over a period after the transplantation to provide data concerning the transition of the concentration to an abnormally high level deviating from the normal range, whereby the probability of the development of acute graft-versus-host disease is predicted, the risk of the development is estimated, or therapeutic effects after the development are evaluated. Concerning the molecular targeted therapy and pharmaceutical preparation used therefor wherein blood DNAM-1 of a GVHD patient or a graft recipient that is a possible patient is used as a target molecule, GVHD is treated or prevented by administering an anti-DNAM-1 antibody that is a neutralizing antibody. | 07-23-2009 |
20090047368 | Polymeric polyphenol extracted from fermented tea, therapeutic agent for mitochondrial disease, preventive/therapeutic agent for diabetes mellitus, and food or beverage - [Problem] To provide a new pharmacological action for high-molecular-weight polyphenols | 02-19-2009 |
20090022782 | Blood Retainable Device Exhibiting Selective Degradability in Tumor Tissue - A phospholipid derivative useful for the preparation of liposomes for efficient uptake of an antitumor agent or a gene intracellularly by a target tumor cell, which comprises a residue of an alcohol compound and a residue of a phospholipid, and comprising a peptide between the residue of an alcohol compound and the residue of a phospholipid, and wherein (a) the alcohol compound is an alcohol compound selected from poly(alkylene glycols) and the like, (b) the phospholipid is a phospholipid selected from phosphatidylethanolamines, phosphatidylcholines, phosphatidylserines and the like, and (c) the peptide is a peptide comprising a substrate peptide that can serve as a substrate of a matrix metalloproteinase, provided that one amino acid residue or an oligopeptide containing 2 to 8 amino acid residues may bind to one or both ends of the substrate peptide. | 01-22-2009 |
20080299579 | NOVEL CANCER MARKER AND USE THEREOF - This invention provides a method for cancer diagnosis comprising measuring an endogenous antisense RNA whose relative expression to a sense RNA changes cancer-specifically in RNA-containing samples collected from a mammal. Also provided are endogenous antisense RNAs useful as cancer markers, and cancer diagnostic reagents containing the same. | 12-04-2008 |