| University of Notre Dame du Lac Patent applications |
| Patent application number | Title | Published |
|---|
| 20120032227 | LOW VOLTAGE TUNNEL FIELD-EFFECT TRANSISTOR (TFET) AND METHOD OF MAKING SAME - A low voltage tunnel field effect transistor includes a p-n tunnel junction, a gate-dielectric, a gate, a source-contact, and a drain-contact. The p-n tunnel junction includes a depletion region interfacing together a source-layer and a drain-layer. The depletion region includes a source-tunneling-region of the source-layer and a drain-tunneling-region of the drain-layer. When no external electric field is imposed, the depletion region of the p-n tunnel junction has an internal electric field that substantially points towards the source-tunneling-region and the drain-tunneling-region. The gate-dielectric is interfaced directly onto the drain-tunneling-region such that the drain-tunneling-region is between the source-tunneling-region and the gate-dielectric. The gate is interfaced onto the gate-dielectric such that the gate is configured to impose an external electric field which is oriented substantially in parallel to the internal electric field of the depletion region. | 02-09-2012 |
| 20110237832 | SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES - Embodiments herein relate to histone deacetylaces (HDACs) and HDAC inhibitors, such as trichostatin A (TSA) and TSA analogues. Embodiments provide simple methods of synthesizing TSA and TSA analogues. These methods provide routes of synthesis of TSA and TSA analogues that enable the production of the HDAC inhibitors at lower cost and in greater quantities than previously were available. | 09-29-2011 |
| 20110118459 | HIGH PERFORMANCE LUMINESCENT COMPOUNDS - Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes. | 05-19-2011 |
| 20110086817 | ANTI-BACTERIAL AGENTS FROM BENZO[D]HETEROCYCLIC SCAFFOLDS FOR PREVENTION AND TREATMENT OF MULTIDRUG RESISTANT BACTERIA - Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria. | 04-14-2011 |
| 20110076305 | EXTRACELLULAR MATRIX MATERIALS AS VACCINE ADJUVANTS FOR DISEASES ASSOCIATED WITH INFECTIOUS PATHOGENS OR TOXINS - Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvant may also be described as a heterologous acellular collagenous tissue preparation. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal. | 03-31-2011 |
| 20110071109 | HISTONE DEACETYLASE INHIBITORS AS THERAPEUTIC AGENTS FOR LYSOSOMAL STORAGE DISORDERS - Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described. | 03-24-2011 |
| 20110021574 | ANTI-CANCER COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME - Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to anti-cancer compounds, synthesis thereof, and methods of using same. Disclosed herein are various heterocyclic compounds and methods of using the novel anti-cancer compounds to inhibit the growth of a cancer cell, for instance a leukemia, non-small cell lung, central nervous system (CNS), skin, ovarian, renal, prostate, breast, or colon cancer cell. Other embodiments include methods of treating cancer in a subject, such as using the disclosed heterocyclic anti-cancer agents. | 01-27-2011 |
| 20100331542 | PROBES FOR ANIONIC CELL SURFACE DETECTION - Embodiments of the present invention are generally directed to compositions comprising a class of molecular probes for detecting the presence of anionic cell surfaces. Embodiments include compositions that are enriched for these compositions and preparations, particularly preparations suitable for use as laboratory/clinical reagents and diagnostic indicators, either alone or as part of a kit. An embodiment of the invention provides for a highly selective agent useful in the discernment and identification of dead or dying cells, such as apoptotic cells, in a relatively calcium-free environment. An embodiment of the invention provides a selective agent for the identification of bacteria in a mixed population of bacterial cells and nonbacterial cells. | 12-30-2010 |
| 20100261673 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME - Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of | 10-14-2010 |
| 20100233214 | Extracellular matrix cancer vaccine adjuvant - Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), trocar, or other solid or semi-solid preparation. The invention provides for enhanced tumor inhibition of 2-fold or greater, compared to vaccine preparations without the extracellular matrix material, or from 4- to 5-fold, compared to preparations without the adjuvant promoting extracellular materials. | 09-16-2010 |
| 20100202669 | IRIS RECOGNITION USING CONSISTENCY INFORMATION - Embodiments of the present invention include but are not limited to methods and systems for iris recognition. An iris recognition method may comprise comparing a plurality of images of an iris to determine at least one of one or more consistent features and one or more inconsistent features of the iris; and constructing an enrollment template for the iris based at least in part on the at least one of the one or more consistent features and the one or more inconsistent features. | 08-12-2010 |
| 20100136050 | Extracellular Matrix Materials as Vaccine Adjuvants for Diseases Associated with Infectious Pathogens or Toxins - Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvants are demonstrated to enhance the immunogenicity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal. | 06-03-2010 |
| 20090252382 | SEGMENTATION OF IRIS IMAGES USING ACTIVE CONTOUR PROCESSING - Aspects of the present invention are generally directed to processing of an obtained iris image. An iris is image is segmented for use in a biometric recognition scheme. | 10-08-2009 |
| 20090114273 | NANOMATERIAL SCAFFOLDS FOR ELECTRON TRANSPORT - Embodiments of the present invention provide nanomaterial scaffolds for transporting electrons. There is provided a single wall carbon nanotube (SWCNT) architecture employed as a conducting scaffold in semiconductor based photoelectrochemical cells. SWCNT architecture provides a nanotube network to disperse nanoparticles and/or quantum dots, whether ordered or randomized. As a result, an increase in incident photon conversion to charge carrier conversion efficiency (IPCE) represents a beneficial role of SWCNT architecture as a conducting scaffold to facilitate charge collection and charge transport in nanostructured semiconductor films. Embodiments may be used for solar cells based on semiconductor quantum dots and nanostructures, solar hydrogen production, microcapacitors and storage batteries, solar-fuel cell hybrids, etc. | 05-07-2009 |
