| University of Maryland, College Park Patent applications |
| Patent application number | Title | Published |
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| 20120122208 | Tubular Bioreactor System for Use in Bone and Cartilage Tissue Engineering - A bioreactor system includes a growth chamber having an inlet, an outlet, and defining a cavity, a media reservoir is in fluid communication with the inlet, and a pump configured to perfuse a media from the reservoir into the inlet and through the growth chamber. A plurality of discrete scaffold members is packed within the growth cavity. Spaces between adjacent scaffold members define pores. The media is movable around the scaffold members and through the pores via the pump. | 05-17-2012 |
| 20120119623 | LEAD-FREE PIEZOCERAMIC MATERIALS - The present invention relates to lead-free piezoelectric ceramic materials comprising crystalline (and preferably perovskite crystalline) structures of the formula Bi | 05-17-2012 |
| 20120119117 | Remote Nanoscale Photochemistry Using Guided Emission in Nanowires - A method of fabricating a nanodevice includes providing a nanowire having a first portion and a second portion. The nanowire has a polymer coating. A nanostructure is provided that is proximate to the second portion of the nanowire. Solely the first portion of the nanowire is irradiated with near-infrared radiation, thereby exciting the first portion to generate ultraviolet radiation. The generated ultraviolet radiation is guided from the first portion along the nanowire toward the second portion, so that a region of the polymer coating on the second portion is polymerized and bonds the nanostructure to the nanowire. | 05-17-2012 |
| 20120112121 | EMULSIONS OF HEAT TRANSFER FLUIDS INCLUDING NANODROPLETS TO ENHANCE THERMAL CONDUCTIVITIES OF THE FLUIDS - A heat transfer fluid emulsion includes a heat transfer fluid, and liquid droplets dispersed within the heat transfer fluid, where the liquid droplets are substantially immiscible with respect to the heat transfer fluid and have dimensions that are no greater than about 100 nanometers. In addition, the thermal conductivity of the heat transfer fluid emulsion is greater than the thermal conductivity of the heat transfer fluid. | 05-10-2012 |
| 20120103822 | ELECTROADDRESSING AND IN-FILM BIOPROCESSING USING STIMULI-RESPONSIVE HYDROGEL-FORMING POLYMERS - Methods for the generation of hydrogels formed by electrodeposition of an electroaddressable polymer are described. The hydrogels may contain one or more cell populations electroaddressed or electroaddressable to a location within the hydrogel and where the cells of the cell populations are entrapped by the hydrogel and are capable of expansion within the hydrogel and may be releasable from the hydrogel. Further provided are electroaddressable polysaccharide blends for the in-film expansion of a cell population, allowing probing of the cells and formation of immunocomplexes. Further provided are methods of using hydrogels containing electroaddressed or electroaddressable cell populations in in-film bioprocessing methods such as cell-based biosensing, protein-based biosensing, and in studies of cell signaling. | 05-03-2012 |
| 20120076730 | PEPTIDES FOR TRANSPORT OF THERAPEUTICS AND THEIR CARRIERS IN MOUSE MODELS AND HUMANS - A system for targeted delivery of agents (e.g., molecular probes, diagnostic agents, therapeutic agents, imaging agents, research or analytical compounds, enzymes, peptides, proteins, lipids, lipoproteins, sugars, hormones, vitamins, nucleic acids, viruses, bacteria, and/or cells) including use of a composition containing the agent and a targeting moiety, specific for a determinant at the target location. An exemplary composition of the system includes a targeting moiety of one of peptides γ3, 2γ3, 3γ3, A1, B7, B8, B9, B1O, and D6, specific for targeting ICAM-I. The system enables effective, versatile, and safe targeting and transport of agents. The system is useful in research applications, as well as in the context of translational science and clinical interventions. | 03-29-2012 |
| 20120009242 | BLOOD COAGULATION INDUCING POLYMER HYDROGEL - The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated. | 01-12-2012 |
| 20120004518 | TECHNIQUES FOR COMPENSATING MOVEMENT OF A TREATMENT TARGET IN A PATIENT - One embodiment includes a method of predicting a position of a target site inside a body using surrogates is provided. The method includes transforming surrogate measurements and target positions into different representations by applying an operator, establishing a special relationship between the transformed surrogate measurements and the transformed target positions, and continuously predicting the target position from the transformed surrogate measurements and the established special relationship. | 01-05-2012 |
| 20110318771 | DEUTERIUM ISOBARIC TAG REAGENTS FOR QUANTITATIVE ANALYSIS - Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more | 12-29-2011 |
| 20110217785 | CHITOSAN-COATED WIRES FOR BIOSENSING - A method of forming a bioelectronic device including a protein on an electrically conductive substrate, by electro-depositing aminopolysaccharide chitosan on the substrate while applying a cathodic voltage to the substrate, to form an aminopolysaccharide chitosan film thereon, applying an anodic voltage to the substrate in the presence of NaCl to activate the aminopolysaccharide chitosan film so that it is reactive with protein. The method also optionally includes reacting the aminopolysaccharide film, after activation thereof, with the protein, so that the protein assembles on and is coupled to the substrate, thereby forming a bioelectronic device. The protein can include single or multiple protein species, and including biosensing proteins. Additional methods include biosensing of electrochemically active compounds either present in a sample or generated during a biological recognition event and devices useful in such methods. The resulting devices are useful as sensors in hand-held devices, textiles, garments and the like. | 09-08-2011 |
| 20110195860 | FIBROUS ASSEMBLIES FOR ANTIBODY PRESENTATION, AND MULTIPLEXED ANTIGENIC ANALYSIS USING SAME - Biofunctionalized fibers including a fiber platform and a histidine-tagged protein and, optionally, an antibody. Chitosan is a fiber useful as the fiber platform. The fiber platform may be treated with nickel or may be directly linked to the histidine-tagged protein e.g., histidine-tagged streptococcal IgG-binding protein, protein G, protein G3T, GFP or RFP. The resulting biofunctionalized fibers can be assembled into protein fiber assemblies by a variety of biofabrication methods. The fiber assemblies, e.g., in the form of woven fabrics, are useful for (i) antigen capture; (ii) immunoanalysis, and/or (iii) multiplexed analysis. In one fabrication, each fiber of a fiber assembly presents a specific antibody, and mixing and matching of fibers, for example by weaving of fabrics from various antibody-presenting fibers, allows for multiple antigens to be captured simultaneously for multiplexed analysis. | 08-11-2011 |
| 20110191102 | SYSTEMS AND METHODS FOR SPEECH EXTRACTION - In some embodiments, a processor-readable medium stores code representing instructions to cause a processor to receive an input signal having a first component and a second component. An estimate of the first component of the input signal is calculated based on an estimate of a pitch of the first component of the input signal. An estimate of the input signal is calculated based on the estimate of the first component of the input signal and an estimate of the second component of the input signal. The estimate of the first component of the input signal is modified based on a scaling function to produce a reconstructed first component of the input signal. The scaling function is a function of at least one of the input signal, the estimate of the first component of the input signal, the estimate of the second component of the input signal, or a residual signal. | 08-04-2011 |
| 20110183140 | Method for Polymer Coating and Functionalization of Metal Nanorods - The present invention relates to polymers and their use in coating metal nanorods (especially gold nanorods), and to the coated nanorods compositions. In particular, the invention relates to a process for forming cetyltrimethylammonium bromide (CTAB)-coated gold nanorods and to such coated nanorods that additionally comprise an external cross-linked polymer coating. | 07-28-2011 |
| 20110085472 | Novel topology selection and broadcast method for rule-based link state routing - An apparatus and method are provided for optimizing the link-state information that is to be broadcast in a routing domain of a communication network for QoS rule-based link-state routing. The routers include any device capable of implementing the routing primitives. The apparatus and method involve pruning the link-state information using local neighborhood information that has been discovered. The local link-state is pruned so that the QoS optimal paths are preserved for link-state routing. Pruning of the potential optimal paths is carried out to minimize the information broadcast to the intra domain routers in an autonomous system/routing domain. The apparatus and method also involve broadcasting the selected link-state information. | 04-14-2011 |
| 20110081677 | Active Microfluidic Membranes - The present invention relates to a biofabricated Active Microfluidic Membrane (AMM) in a microfluidic network of a microfluidic device and a method for the in situ biofabrication of such a microfluidic network. More specifically, the invention relates to devices exhibiting (and methods of) positioning (i.e., erecting, modifying or removing a membrane matrix in situ in a microchannel of a microfluidic network of a microfluidic device. In one embodiment, the membrane comprises a single type of matrix constituent, such as chitosan, alginate, etc. Alternatively, the membrane may be composed of two or more matrix constituents, which may be integrated into one another or layered adjacent to one another. | 04-07-2011 |
| 20110054237 | Methods and Systems for Magnetic Focusing of Therapeutic, Diagnostic or Prophylactic Agents to Deep Targets - Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the treatment of diseased areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas deep within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents. | 03-03-2011 |
| 20110008869 | ENGINEERED PROTEASES FOR AFFINITY PURIFICATION AND PROCESSING OF FUSION PROTEINS - The present invention is directed to the identification of a protease prodomain that is capable of binding a corresponding protease with high affinity. The protease prodomain of the present invention is fused to a second protein to form a protease prodomain fusion protein. The presence of a protease prodomain protein in a fusion protein allows for easy and selective purification of the second protein by incubation with the corresponding protease. | 01-13-2011 |
| 20100280286 | Process For The Preparation of Beta and Alpha Cryptoxanthin - The present invention relates to a process for converting lutein and/or lutein esters to (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin, suitable for human consumption as dietary supplements, by employing safe and environmentally friendly reagents. (3R)-β-Cryptoxanthin and (3R,6′R)-α-cryptoxanthin are two rare food carotenoids that are not commercially available and the former exhibits vitamin A activity. In the first synthetic step, commercially available lutein and/or lutein esters are transformed into a mixture of dehydration products of lutein (anhydroluteins) in the presence of a catalytic amount of an acid. The resulting anhydroluteins are then converted to (3R)-β-cryptoxanthin (major product) and (3R,6′R)-α-cryptoxanthin (minor product) by heterogeneous catalytic hydrogenation employing transition elements of group VIII (Pt, Pd, Rh supported on alumina or carbon) in a variety of organic solvents under atmospheric pressure of hydrogen and at temperatures ranging from −15° C. to 40° C. Among these catalysts, Pt supported on alumina at 40° C. in ethyl acetate provides the best yield of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin. Several homogeneous catalysts can also promote the regioselective hydrogenation of anhydroluteins to a mixture of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin in low to moderate yields. The catalysts may be transition metal complexes such as palladium acetylacetonate, Rh(Ph | 11-04-2010 |
| 20100272256 | Method and Implementation for Information Exchange Using Markov Models - The replacement of secret keys is a central problem in key management. Typical solutions exchange handshaking messages, involve complex computations, or require the cooperation of trusted third parties. Disclosed herein is a key replacement method that exploits the randomness of Markov models to efficiently provide fresh keys to users. Unlike other methods, the proposed method removes the need for extra communications, intensive computation, or third parties. It is demonstrated that the proposed method has perfect forward secrecy as well as resistance to known-key attacks. | 10-28-2010 |
| 20100266897 | High-Powered Electrochemical Energy Storage Devices and Methods for Their Fabrication - The present invention relates to electrochemical storage devices, such as supercapacitors, batteries, etc., and more particularly to such devices that comprise an electrochemically active coaxial nanowire. The invention particularly concerns such devices in which the coaxial nanowire comprises an inner core of a transition metal oxide and an axially surrounding outer shell composed of an electroconductive organic polymer, such as poly(3,4-ethylenedioxythiophene) (PEDOT). The invention particularly relates to a facile method for achieving the self-assembly of such coaxial nanowires. | 10-21-2010 |
| 20100255383 | Polymer Solid Electrolyte for Flexible Batteries - A flexible polymer solid electrolyte material useful in battery technology is described. The flexible solid electrolyte comprises a first block that has the ability to solvate alkali metal salts. The flexible solid electrolyte comprises a second block that has the ability to incorporate lithium ions within microphase separated spherical domains, wherein the lithium ions are from a secondary lithium source. The flexible solid electrolyte further comprises a second lithium salt. | 10-07-2010 |
| 20100096043 | High Temperature Solder Materials - A solder material is formed utilizing a transient liquid phase sintering process, where a precursor material is first formed. The precursor material comprises a plurality of metal particles including a first metal having a first melting point temperature and a second metal having a second melting point temperature, the first melting point temperature being greater than the second melting point temperature. The precursor material is heated to a process temperature (T | 04-22-2010 |
| 20090209703 | Methods for Modulated Degenerative Transfer Living Polymerization and Isotactic-Atactic Stereoblock and Stereogradient Poly(Olefins) Thereby - Methods for modulated degenerative transfer living polymerization and isotactic-atactic stereoblock and stereogradient poly(olefins) thereby Abstract A method of producing a multiblock, stereoblock polyolefin having substantially uniform microstructure is disclosed. The method includes contacting a Ziegler-Natta pre-catalyst with a co-catalyst and an olefin to polymerize the olefin and form a first stereoblock, adding a methyl donator that changes the stereoregularity of the polymerization, and polymerizing the olefin to form a second stereoblock. The methods of the present invention allow for the production of poly(olefin)s having predictable degrees of incorporation of stereoerrors of a known type. The methods allows for the production of a variety of poly(olefin) microstructures, ranging from stereoblock to stereogradient poly(olefin)s and poly(olefin)s having fully isotactic to fully atactic microstructures. | 08-20-2009 |
| 20090093638 | Allylic Oxidations Catalyzed by Dirhodium Catalysts under Aqueous Conditions - The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The invention concerns the use of dirhodium (II,II) “paddlewheel complexes, and in particular, dirhodium carboximate and tert-butyl hydroperoxide as catalysts for the reaction. The use of aqueous conditions is particularly advantageous in the allylic oxidation of 7-keto steroids, which could not be effectively oxidized using anhydrous methods, and in extending allylic oxidation to enamides and enol ethers. | 04-09-2009 |
| 20080277631 | Electrically Conductive Metal Impregnated Elastomer Materials and Methods of Forming Electrically Conductive Metal Impregnated Elastomer Materials - An electrically conductive, compliant elastomer material that is impregnated with a metal is formed by combining a metal salt with an elastomer precursor material to form a metal salt/precursor mixture, curing the metal salt/precursor mixture to form an elastomer impregnated with metal salt, and treating the elastomer impregnated with metal salt with a chemical reducing composition so as to convert at least a portion of the metal salt impregnated within the elastomer to a metal. The elastomer can be subjected to a suitable solvent that swells the elastomer during the chemical reduction of the metal salt to metal, which enhances the mechanical and electrical properties of the resultant metal impregnated elastomer material. | 11-13-2008 |
| 20080241185 | IMPRINTED POLYMERIC MATERIALS FOR BINDING VARIOUS TARGETS SUCH AS VIRUSES - Imprinted polymeric materials that selectively bind to a template article. Various types of template articles may be targeted by the imprinted polymeric materials, including microorganisms (e.g., viruses or bacteria) or biologic macromolecules (e.g., proteins or DNA). The imprinted polymeric material may be formed by template-directed synthesis using monomer units that interact with the template article. The monomer units are used to form a polymer matrix around the template article. Subsequently, the template article is removed from the polymer matrix. Also disclosed are imprinted polymeric materials comprising a cross-linked polymer matrix, which comprises a polyampholyte polymer. The polymer matrix has a binding cavity capable of selectively binding to a template article. Also disclosed are various uses for such imprinted polymeric materials. | 10-02-2008 |
| 20080212737 | Techniques For Compensating Movement of a Treatment Target in a Patient - Techniques for improving treatment delivered to a target site in a patient include delivering a treatment from a treatment delivery device to a target site in a patient supported by a patient support structure. During the delivery of treatment, a state of the patient is measured to produce real-time measurement data. Measuring the state is non-invasive; and the measured state is a correlated surrogate for position of the target site. Compensating movement data is determined based on the real-time measurement data to cause the target site to maintain a particular spatial relationship with the treatment delivery device. Either the treatment delivery device, or the support structure, or both, are moved based on the compensating movement data. When the delivery device alone is moved, the correlation between measured state and target site is based on partial least squares applied to pre-treatment measurements of both. | 09-04-2008 |
