| University of Manitoba Patent applications |
| Patent application number | Title | Published |
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| 20120115774 | ANTIMICROBIAL CATIONIC LIPO-BETA-PEPTIDES - In some aspects, the present invention provides ultrashort lipopeptides which feature β-amino acids or β-peptides and demonstrate antimicrobial activity. Accordingly, some aspects of the present invention provide lipopeptide compositions and methods of making and using the compositions as antimicrobial agents. | 05-10-2012 |
| 20110315932 | SELF-DOPED POLYANILINE NANOPARTICLE DISPERSIONS BASED ON BORONIC ACID-PHOSPHATE COMPLEXATION - Poly(anilineboronic acid)/phosphate nanoparticle dispersions are produced in high yields using the reactivity of the boronic acid moiety with phosphate in the presence of fluoride. The poly(anilineboronic acid)/phosphate dispersions have been characterized using spectroscopic, microscopic and electrochemical techniques. According to | 12-29-2011 |
| 20110230434 | USE OF S-ADENOSYLMETHIONINE, VITAMIN E, AND VITAMIN C FOR THE TREATMENT OF OXIDATIVE LIVER INJURY OR INSULIN RESISTANCE - The present invention provides antioxidant compositions comprising S-adenosylmethionine (SAMe), vitamin E and vitamin C and uses thereof for the treatment of liver injury and insulin resistance. | 09-22-2011 |
| 20110227586 | MICROWAVE TOMOGRAPHY SYSTEMS AND METHODS - Methods and/or systems are disclosed herein for use in imaging an object with microwave tomography using a plurality of different boundary conditions. | 09-22-2011 |
| 20110219858 | COMPOSITION FOR USE AS A PEPTIDE RETENTION STANDARD AND A METHOD OF PREDICTING PEPTIDE HYDROPHOBICITY IN LIQUID CHROMATOGRAPHY - A composition comprising synthetic peptides for use as a peptide retention standard in liquid chromatography applications is disclosed Said synthetic peptides have a broad range of hydrophobicity while maintaining low variation in their molecular weights The synthetic peptides disclosed consist of the ammo acid sequences LGGGGGGDGSR, LGGGGGGDFR, LLGGGGDFG, LLLGGDFR, LLLLDFR, LLLLLDFR A method of predicting the hydrophobicity of an unknown peptide in liquid chromatography using a composition of peptide retention standards and a method of developing a Universal Hydrophobicity Index (UHI) for the measurement of peptide hydrophobicity in liquid chromatography are also described | 09-15-2011 |
| 20110178037 | HYDROPHOBICALLY ENHANCED AMINOGLYCOSIDES - Hydrophobically enhanced aminoglycosides have been prepared and shown to be effective antibacterial agents. These agents may be used in the treatment or prevention of various bacterial infections. Methods of preparing these agents also permit facile synthetic access. Formula (I). | 07-21-2011 |
| 20110104972 | PROTECTIVE BARRIER HAVING SELF-DECONTAMINATING PROPERTIES - A protective material includes a porous substrate having cross-linked self-decontaminating polymer grafted thereon, the cross-linked self-decontaminating polymer having been converted after grafting to activate self-decontaminating function. The cross-linked self-decontaminating polymer provides the protective material with reversible swelling ability to block the porous substrate when the protective barrier is contacted by liquids. | 05-05-2011 |
| 20110046907 | SYSTEM AND METHODS OF IMPROVED TOMOGRAPHY IMAGING - The present invention is a system and methods of improved tomography imaging such as microwave tomography (MWT). An improved inversion technique surrounds the imaging region with an electrically conducting surface to create field distortions producing an improved tomographic image. The improved inversion technique of the present invention creates a new physical situation for proposed imaging systems. | 02-24-2011 |
| 20110045139 | FERMENTED SAUSAGE AND METHODS OF MAKING SAME - The present invention provides methods for producing a fermented sausage, such as a semi-dry or dry fermented sausage. The methods include adding to a sausage batter a processed mustard, where the processed mustard may include characteristics chosen from a total phenolic content of at least 21 mg FAE/gram processed mustard, an antioxidant capacity of at least 900 micromol/100 grams processed mustard, no detectable myrosinase activity, and a combination thereof. The present invention also provides fermented sausage, such as a dry fermented sausage, that includes vegetable protein. The vegetable protein may be at a level of at least 0.01% (wt/wt). | 02-24-2011 |
| 20110014174 | Lysozyme, A Novel Vasodilator of Sepsis that can be inhibited by a Peroxidase and Hydroxyl Radical Scavengers - A method of reducing a vasodilatory response comprising administering to an individual in need of such treatment an effective amount of a guanylate cyclase pathway inhibitor selected from the group consisting of methylene blue, ODQ, LY83583 and a protein kinase G inhibitor or an H | 01-20-2011 |
| 20100261639 | TRIAZOLE-BASED AMINOGLYCOSIDE-PEPTIDE CONJUGATES AND METHODS OF USE - Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycoside antibiotic may exhibit antimicrobial activities against Gram-positive and/or Gram-negative strains and display significantly enhanced activity against multi-drug resistant MRSA and MRSE when compared to their unconjugated aminoglycoside antibiotic counterparts. | 10-14-2010 |
| 20100253417 | Conducting Polymer for Electronic, Photonic and Electromechanical Systems - The present invention concerns doped organic semiconductors composites. In certain aspects, organic polymers are doped with large anions, such as DBS | 10-07-2010 |
| 20100195008 | PLANAR NEMATIC LIQUID CRYSTAL CELLS DOPED WITH NANOPARTICLES AND METHODS OF INDUCING A FREEDERICKSZ TRANSITION - Nematic liquid crystal cells with positive dielectric anisotropy that include colloidal suspensions having nanoclusters are provided as well as methods of inducing Freedericksz transitions therein and methods of controlling the alignment of a liquid crystal. | 08-05-2010 |
| 20100183557 | PTRA GENE AND USES THEREOF - An isolated nucleic acid molecule comprising a nucleotide sequence set forth in SEQ ID NO: 1, said nucleotide sequence encoding a protein inhibitory to | 07-22-2010 |
| 20100144660 | USE OF N,N-DIETHYL-2-[-4-(PHENYLMETHYL)-PHENOXY]ETHANAMINE MONOHYDROCHLORIDE (DPPE) IN CANCER THEREAPY - The present invention provides for the use of N,N-diethyl-2-[-4-(phenylmethyl)-phenoxy]ethanamine monohydrochloride (DPPE) in cancer therapy. DPPE is used in the treatment of patients having, or suspected of having, an aggressive cancer. The present invention further provides for the use of DPPE in the treatment of a patient suspected of having an existing cancer, wherein the use follows a surgery for treatment of a primary cancer that is estrogen-receptor negative. Also provided are pharmaceutical compositions comprising DPPE for use in the treatment of patients having, or suspected of having, an aggressive cancer and pharmaceutical kits comprising such compositions. | 06-10-2010 |
| 20100123073 | ELECTRON CAPTURE DISSOCIATION IN A MASS SPECTROMETER - A mass spectrometer, that may be a time of flight mass spectrometer, has a source of ions having desired characteristics. The mass spectrometer section includes a modulator and first and second apertures on opposite sides of the modulator, with the first aperture providing a connection to the source of ions. A cell is connected to the modulator of the time-of flight mass spectrometer section by the second aperture, whereby, in use, ions from the source of ions can pass through the first aperture, the modulator and the second aperture into the cell, for capture of electrons or collision with a gas, to generate daughter ions, and the daughter ions are passed back into the time-of-flight or other mass spectrometer section for analysis. | 05-20-2010 |
| 20090324565 | A Colicinogenic Strain of E. Coli - Described herein is the isolation of colicin-producing strains of | 12-31-2009 |
| 20090305267 | MICROBIAL MARKERS OF INFLAMMATORY BOWEL DISEASE - The present invention relates to bacterial serine protease autotransporter (SPATE) and Antigen 43 (Ag43) and their various uses relating to inflammatory bowel disease (IBD), specifically in the diagnosis of IBD and the screening of potential agent for treating IBD. The invention also relates to methods for cultivating and identifying enteric microbes. | 12-10-2009 |
| 20090299031 | Metastable Reaction Mixtures For The In Situ Polymerization Of Conducting Polymers - Conducting polythiophene films are produced by the oxidation of bithiophene or terthiophene monomers using phosphomolybdic acid, wherein the reagents are first combined to form a metastable solution, the solution is then cast as a film, and polymerisation ultimately initiated by evaporation of the solvent The equivalent formation of polypyrrole via the oxidation of pyrrole using phosphomolybdic acid has been previously demonstrated, but this approach cannot be applied directly to thiophene, which has too high an oxidation potential Bithiophene and terthiophene have lower oxidation potentials, close to that of pyrrole This work suggests the previously demonstrated method is suitable for general application, requiring only the proper matching of monomer and oxidant redox potentials, and the selection of a suitable solvent and starting concentration Smooth, spin-coated polythiophene films having thicknesses of 100 to 200 run and conductivities in the range 0.2 to 0.3 S-cm | 12-03-2009 |
| 20090270311 | TREATMENT OF INSULIN RESISTANCE BY MODULATING SOMATOSTATIN USING SOMATOSTATIN RECEPTOR ANTAGONISTS - The present invention provides the use of somatostatin antagonists for treating and preventing HISS-dependent insulin resistance and hemorrhage induced insulin resistance. The present further provides pharmaceutical compositions comprising a somatostatin antagonist and a pharmaceutically acceptable liver targeting compound. | 10-29-2009 |
| 20090093010 | Method of Detecting Kidney Dysfunction - Methods and kits for monitoring kidney function, and detecting kidney dysfunction and transplant related disease and rejection are disclosed. The method involves analyzing a sample, such as a urine sample, containing protein from an animal for fragments of β2-microglobulin, wherein the presence of specific β2-microglobulin fragments is indicative of kidney dysfunction and transplant rejection. In another embodiement, urine samples from an animal are tested for protease activity, such as cathepsin D or napsin A, wherein increased protease activity compared to a control sample is indicative of kidney dysfunction. | 04-09-2009 |
| 20080275213 | Synthesis of Carbohydrate-Templated Amino Acids and Methods of Using Same - The present invention generally relates to tetrahydropyranyl-derivatized amino acids, their syntheses and their incorporation into peptides and peptidomimetics. The tetrahydropyran moiety constrains the side chain of an amino acid, thereby providing a molecule that may act as a sugar- or amino acid-mimetic as well as a scaffold for combinatorial synthesis. | 11-06-2008 |
| 20080262002 | Use of S-Adenosylmethionine, Vitamin E, and Vitamin C for the Treatment of Oxidative Liver Injury or Insulin Resistance - The present invention provides antioxidant compositions comprising S-adenosylmethionine (SAMe), vitamin E and vitamin C and uses thereof for the treatment of liver injury and insulin resistance. | 10-23-2008 |
| 20080255062 | AXON REGENERATION FROM ADULT SENSORY NEURONS - A method for rapidly screening small molecules to identify small molecules that stimulate axon regeneration and outgrowth from adult sensory neurons. The method generally comprises preparing a purified individualized dorsal root ganglia cell suspension (DRG), coating well surfaces of a suitably prepared multi-well microplate with the DRG, then dispensing dosages of selected small molecules into selected wells. The microplates are incubated under sterile conditions at about 37° C. for at least 24 hours. The DRG suspension in each well is then morphometrically assessed to assess the extent of axon regeneration and outgrowth that occurred, and the effects of the selected small molecules are determined by comparison to control treatments. The method is suitable for screening chemically derived small molecules and biologically derived small molecules. | 10-16-2008 |
| 20080235828 | PLANT PROTEINS HAVING AN ABSCISIC ACID BINDING SITE AND METHODS OF USE - Compositions and methods for modifying the sensitivity to abscisic acid, of seeds and vegetative tissues of plants. The compositions comprise novel nucleotide molecules configured for expressing an abscisic acid-binding protein, i.e., ABAP1, comprising an amino acid sequence set forth in SEQ ID NO: 10. The methods comprise the steps of constructing a nucleotide molecule by fusing a nucleotide coding sequence set forth in SEQ ID NO: 9 with a regulatory nucleotide sequence selected for over-expression or for under-expression of the coding sequence, stably introducing the nucleotide molecule into the genome of a recipient cell from a seed-producing plant, culturing the recipient cell into a whole recipient plant and then further culturing the recipient plant to produce mature recipient seeds, and harvesting the recipient seeds. The recipient seeds and whole plants produced therefrom have modified sensitivities to ABA thereby enabling regulation of germination, physiological function and plant productivity. | 09-25-2008 |
