| UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. Patent applications |
| Patent application number | Title | Published |
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| 20120132798 | PRECONCENTRATOR FOR ANALYSIS INSTRUMENTS - An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path. | 05-31-2012 |
| 20120122723 | METHODS OF DETECTING AUTOANTIBODIES FOR DIAGNOSING AND CHARACTERIZING DISORDERS - Methods for detecting and/or quantitating levels of autoantibodies in subjects are provided. Methods for diagnosing and/or characterizing a disorder associated with autoantibody production are further provided. In some embodiments, the disorder diagnosed and/or characterized can be a cancer or an infertility disorder. | 05-17-2012 |
| 20120101747 | DETECTION AND IMAGING OF TURBULENCE IN A FLUID - A system and method detect turbulence in a fluid by processing image data to isolate and detect fluctuations in a frequency range indicative of turbulence. By making use of a Fourier or other frequency transformation to convert a set of time-dependent intensity data into frequency-dependent intensity data, a range of frequencies can be selected wherein fluctuations in intensity are characteristic of turbulence, even under difficult conditions where turbulence is cannot be naively detected. A detector is capable of relying on ambient light conditions to provide sufficient transmission and fluctuation to detect the characteristics of turbulence. Detection of turbulence aids in aircraft navigation and meteorology, analysis of industrial and commercial exhaust, and detection of unexpected fluid events such as containment leaks. | 04-26-2012 |
| 20120083440 | METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH - Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (R | 04-05-2012 |
| 20120059395 | ENDOSCOPIC CLOSURE DEVICE - An endoscopic closure device comprises: a coupling member; a helical needle mounted to the coupling member and carrying a suture; and a plurality of grasping needles, each of said plurality of grasping needles moveable between a storage position and a deployed position. The plurality of grasping needles is configured to be (a) advanced in the storage position into a luminal defect, (b) moved into the deployed position, and (c) then refracted from the luminal defect, thus pulling and drawing tissue surrounding the luminal defect together. Then, upon rotation of the coupling member and the helical needle, the helical needle is driven into and pierces the tissue, carrying the suture through the tissue. | 03-08-2012 |
| 20120028272 | DEVICE AND METHODS FOR ISOLATING CELLS - The invention provides a device and methods for separating and isolating cells. | 02-02-2012 |
| 20120028124 | ANODE MATERIALS FOR LITHIUM-ION BATTERIES - An anode material for lithium-ion batteries is provided that comprises an elongated core structure capable of forming an alloy with lithium; and a plurality of nanostructures placed on a surface of the core structure, with each nanostructure being capable of forming an alloy with lithium and spaced at a predetermined distance from adjacent nanostructures. | 02-02-2012 |
| 20120009606 | PEPTIDE BIOMARKERS PREDICTIVE OF RENAL FUNCTION DECLINE AND KIDNEY DISEASE - The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease. | 01-12-2012 |
| 20110318761 | METHODS AND KITS FOR PREDICTING A RESPONSE TO AN ERYTHROPOIETIC AGENT - Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17. | 12-29-2011 |
| 20110311442 | DIRECT CELLULAR ENERGY DELIVERY SYSTEM - A lipid vesicle comprising a phospholipid which is a stable vesicle former and at least one unstable vesicle forming member, wherein the unstable vesicle forming member is selected from the group consisting of a polar lipid which is not a stable vesicle former, a PEG, a raft former and a fusion protein is provided. The vesicle can further comprise a biomolecule, such as for example ATP. Methods of using the vesicle for delivery of biomolecules are also provided. | 12-22-2011 |
| 20110301860 | USING DIFFERENTIAL SCANNING CALORIMETRY (DSC) FOR DETECTION OF INFLAMMATORY DISEASE - Disclosed herein in various embodiments are systems and methods for categorizing biological fluids obtained from subjects into one or more disease or treatment categories. Embodiments of the systems and methods may transform easily obtainable body fluids such as blood, plasma, spinal fluid, and other fluids into signature differential scanning calorimetry (DSC) thermograms that may be used to distinguish a positive or negative correlation with a specific inflammatory disease, such as an autoimmune disease. Also disclosed are methods of detecting, diagnosing, and/or monitoring an inflammatory disease in a subject. | 12-08-2011 |
| 20110295027 | Catalytic Isomerisation of Fatty Acid Esters - Catalytic isomerisation of fatty acid esters to form branched fatty acid esters comprises the steps of contacting a feedstock having at least one fatty acid ester with a catalyst and isolating from other reaction products branched fatty acid esters that are produced. The catalyst is a crystalline porous silicoaluminophosphate catalyst having silicon, aluminum, and phosphorous atoms in lattice framework positions. The branched fatty acid esters formed thereby demonstrate properties suitable for use in various applications. | 12-01-2011 |
| 20110283957 | DECUBITUS ULCER PREVENTION GARMENT FOR DOGS - Decubitus ulcer prevention garments for a dog are provided that include a fluid-filled bladder. The garments can include an inner layer that contacts and interacts with the body of the dog; an intermediate layer that interfaces with the inner layer and includes the fluid-filled bladder; and an outer layer joined to the inner layer and interfacing with the intermediate layer. The garments have a shape that is adapted to fit over and envelop the pelvic region of the dog such that the garments alleviate or reduce pressure on the soft tissues overlying the boney prominences of the pelvic region of a dog when the dog is lying in a recumbent position on a surface. | 11-24-2011 |
| 20110257211 | Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics - Small molecule choline kinase inhibitors having the following formula: | 10-20-2011 |
| 20110224091 | METHOD AND DEVICE FOR DETECTING CELLULAR TARGETS IN BODILY SOURCES USING CARBON NANOTUBE THIN FILM - A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (CNT's). When antibodies are absorbed by the CNT's, cellular targets having markers matching the antibodies may be detected in a bodily source placed upon the biofunctional pad by measuring the conductivity of the thin film using conductive contacts electrically coupled to the thin film, as the binding of the receptors in the cellular targets to the antibodies changes the free energy in the thin film. In many respects, the device functions as a Field Effect Transistor (FET) with the bodily source, e.g., blood, acting as a polyelectrolyte liquid gate electrode to create a varying electrostatic charge or capacitance in the thin film based upon the binding of cellular targets in the source to the antibodies present on the biofunctional pad. | 09-15-2011 |
| 20110217719 | METHODS AND KITS FOR DIAGNOSING OBSTRUCTIVE SLEEP APNEA - The presently-disclosed subject matter provides methods and kits for diagnosing obstructive sleep apnea (OSA) in a subject, such as a human child, wherein a biological sample is provided from the subject and the amount of a Urocortin III peptide is determined from the sample. Further provided are methods for diagnosing OSA in a subject wherein the amount of a Urocortin III peptide and one or more peptides selected from a Uromodulin peptide, an Orosomucoid 1 peptide, and a Kallikrein 1 peptide are determined in a biological sample from a subject. | 09-08-2011 |
| 20110214482 | LARGE VOLUME ANALYTE PRECONCENTRATOR - A large volume preconcentrator device for concentrating analytes. A housing accepts an analyte vapor flow, and a plurality of collection surfaces are disposed within the housing. A selectively actuatable heater is disposed on each of the plurality of collection surfaces. At least one selectively actuable damper is disposed within the housing for selectively restricting a collection flow. | 09-08-2011 |
| 20110213019 | Compositions and Methods for Treating Cancer, Inhibiting Proliferation, and Inducing Cell Death - Quadruplex-forming guanine-rich nucleic acid sequences are useful in compositions and methods for inhibiting cellular growth and proliferation and inducing cell death. Compositions for treating a patient are provided, including (i) a safe and effective amount of a sequence having at least 80% nucleic acid identity with a guanine-rich promoter gene oligonucleotide (GPGO), and (ii) a carrier, wherein the oligonucleotide forms at least one quadruplex. | 09-01-2011 |
| 20110209604 | COMPOSITE ARMOR PANEL - A composite armor panels is comprised of a first layer, composed of a matrix of an elastomeric material and a crushed aggregate material, and a second backing layer. One or more geogrids can be included in the first layer of the armor panel to prevent the aggregate material from moving within the first layer. A method of making a composite armor panel includes exposing a mixture of elastomeric material and crushed aggregate material to elevated temperatures and pressures for predetermined time periods, such that a matrix of elastomeric material and crushed aggregate material is formed. | 09-01-2011 |
| 20110178020 | METHODS AND COMPOSITIONS FOR INHIBITION OF NEUTROPHIL EXOCYTOSIS - Isolated fusion polypeptides are provided that are comprised of a cell-penetrating polypeptide and a SNARE polypeptide aptamer. Further provided are methods for inhibiting neutrophil granule exocytosis that comprise contacting a neutrophil with a fusion polypeptide including a cell-penetrating polypeptide and a SNARE polypeptide aptamer such that the fusion polypeptide enters the neutrophil and inhibits neutrophil granule exocytosis. Also provided are methods for treating a neutrophil-mediated inflammatory disorder by inhibiting SNARE-associated exocytosis in neutrophils. | 07-21-2011 |
| 20110159016 | HEMOGLOBIN-BASED METHODS FOR PROPHYLAXIS, DIAGNOSIS AND/OR TREATMENT OF RETINAL DISORDERS - The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue. | 06-30-2011 |
| 20110143341 | Microsatellite Markers of Schizophrenia - The invention includes methods of determining if a subject is at risk for developing schizophrenia (SZ). | 06-16-2011 |
| 20110130457 | Wax-Based Emulsion for the Treatment of Dry Eye Conditions - Disclosed herein is a wax-based emulsion for the treatment of dry eye conditions by reducing the evaporation rate of saline and increasing the viscosity of the tear film. The composition of the present invention comprises an emulsion of wax dispersed in saline. One embodiment of the wax-based emulsion of the present invention comprises a wax in an amount ranging from about 0.001% to about 80% by weight and the remainder saline. In another embodiment, the wax-based emulsion further comprises a hydrocarbon in an amount ranging from about 0.01% to about 80% by weight. In still another embodiment, the wax-based emulsion of the present invention further comprises a cholesterol ester ranging in an amount from about 0.01% to about 80% by weight. In an alternative embodiment, the wax-based emulsion of the present invention further comprises an opthalmic drug in an amount ranging from about 0.01% to about 80% by weight. In yet another embodiment, the wax based emulsion comprises a wax in an amount ranging from about 40% to about 60% by weight, a cholesterol ester in an amount ranging from about 10% to about 20% by weight and the remainder saline. The wax based emulsion may further comprise a hydrocarbon in an amount of up to about 20% by weight. In yet another embodiment, the emulsion further comprises an amount ranging between about 1% to about 20% by weight of standard opthalmic drugs such as antibiotics for delivery to the eye. In some embodiments, the wax of the emulsion is a synthetic wax. | 06-02-2011 |
| 20110117548 | Detecting Fetal Chromosomal Abnormalities Using Tandem Single Nucleotide Polymorphisms - The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome. | 05-19-2011 |
| 20110117215 | Microsatellite Markers of Schizophrenia - The invention includes method of determining if a subject is at risk for developing schizophrenia (SZ), schizotypal personality disorder (SPD), or schizoaffective disorder (SD). | 05-19-2011 |
| 20110104074 | METHODS FOR TARGETED CANCER TREATMENT AND DETECTION - A method for treating a cancer is provided that comprises identifying a subject in need of treatment for a cancer and administering to the subject a composition that is comprised of a plurality of a ligand for a luteinizing hormone-releasing hormone receptor and a plurality of a chemotherapeutic agent, where each ligand and each chemotherapeutic agent are conjugated to a nanoparticle. Further provided are methods for detecting a cancer in a subject that comprise administering to a subject an imaging agent comprised of a plurality of a ligand for a luteinizing hormone-releasing hormone receptor conjugated to a nanoparticle. | 05-05-2011 |
| 20110104070 | SITE SPECIFIC FLUORESCENCE AND CONTRAST MARKER FOR SAME - A contrast marker for indicating a presence of a target cell in an environment comprises a fluorophore, an NMP, and a short spacer and a long spacer linking the fluorophore to the NMP. The short spacer holds the fluorophore at a quenching distance from the NMP and the long spacer holds the fluorophore at a fluorescence enhancing distance from the NMP. The short spacer is configured to be cleaved by a molecule characterizing the target cells. | 05-05-2011 |
| 20110100817 | MICROFLUIDIC DEVICES AND METHODS OF USING SAME - The presently-disclosed subject matter provides microfluidic devices comprised of two or more carbon nanotube membranes disposed at predetermined intervals within a microchannel. Further provided are methods of using the same for the electrokinetic separation of one or more molecules of interest from a sample. | 05-05-2011 |
| 20110081669 | SYSTEMS AND METHODS FOR DIAGNOSIS AND PROGNOSIS OF CANCER - Methods for diagnosing a cancer in a subject are provided that include determining an amount of autoantibodies immunoreactive to procathepsin D (pCD) in a sample obtained from the subject. Further provided are systems for diagnosing a cancer in a subject that include an autoantibody immunoreactive pCD antigen and a means for detecting binding of an autoantibody to the antigen. | 04-07-2011 |
| 20110065115 | METHODS FOR IDENTIFYING AN INCREASED LIKELIHOOD OF RECURRENCE OF BREAST CANCER - Methods of identifying a mammal having an increased likelihood of recurrence of breast cancer includes identifying in a breast tissue sample of the mammal expression of at least two genes selected from the group consisting of Hs.125867 (EVL), Hs.591847 (NAT1), Hs.208124 (ESR1), Hs.26225 (GABRP), Hs.408614 (ST8SIA1), Hs.480819 (TBC1D9), Hs.504115 (TRIM29), Hs.523468 (SCUBE2), Hs.532082 (IL6ST), Hs.592121 (RABEP1), Hs.79136 (SLC39A6), Hs.82128 (TPBG), Hs.95243 (TCEAL1), Hs.95612 (DSC2), Hs.654961 (FUT8), Hs.1594 (CENPA), Hs.184339 (MELK), Hs.26010 (PFKP), Hs.592049 (PLK1), Hs.370834 (ATAD2), Hs.437638 (XBP1), Hs.444118 (MCM6), Hs.469649 (BUB1), Hs.470477 (PTP4A2), Hs.473583 (YBX1), Hs.480938 (LRBA), Hs.524134 (GATA3), Hs.531668 (CX3CL1), Hs.532824 (MAPRE2), Hs.591314 (GMPS), Hs.83758 (CKS2) and Hs.99962 (SLC43A3) and subsets of the genes. | 03-17-2011 |
| 20110048133 | VIBRATION ELEMENT COUPLED WITH NON-LINEAR FORCE TO IMPROVE NON-RESONANT FREQUENCY RESPONSE - Embodiments of the invention couple a non-linear force to a vibration element such as a piezoelectric cantilever to introduce chaotic, i.e., non-resonant vibration in the vibration element and thereby improve the non-resonant response of the vibration element. By doing so, the vibration element is responsive to a wider frequency range of vibrations and thus may be more efficient in scavenging energy in environments where the vibration frequency is not constant, e.g., in environment subject to multi-mode or random vibration sources. | 03-03-2011 |
| 20110009412 | MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME - Methods of inhibiting one or more biological activities of Macrophage migration inhibitory factor (MIF) polypeptides are provided using an MIF inhibitory compound. The methods include therapeutic methods for treating cancers and inflammatory diseases. | 01-13-2011 |
| 20100322895 | T CELL DEPLETING COMPOSITIONS USEFUL FOR TREATING CANCER - The presently-disclosed subject matter provides methods and compositions for treating or reducing the risk of recurrence of a cancer in a subject. The methods comprise administering an effective amount of a T cell depleting composition to the subject to thereby treat the cancer. | 12-23-2010 |
| 20100317567 | DIAGNOSING AND PROTECTING HORSES AGAINST PAPILLOMAVIRUS - Compositions for conferring protection against Equus caballus papillomavirus (EcPV) and Bovine papillomavirus (BPV) infection in a subject are provided and include a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods for protecting a subject against EcPV and BPV infection are further provided and include administering to the subject a composition comprised of a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods of diagnosing EcPV and/or BPV infection in a subject are also provided and include providing a virus-like particle assembled from a papillomavirus L1 protein selected from an EcPV L1 protein and a BPV L1 protein; contacting the virus-like particle with serum from the subject; and identifying the subject as having an infection if an antibody capable of binding the virus-like particle is detected in the serum. | 12-16-2010 |
| 20100298151 | EXOSOME-ASSOCIATED MICRORNA AS A DIAGNOSTIC MARKER - The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more microRNAs present in cancer-derived exosomes isolated from a biological sample from the subject. | 11-25-2010 |
| 20100267815 | PFKFB4 Inhibitors And Methods Of Using The Same - Methods of reducing expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) and methods of treating a cancer in a cell are provided, the methods including contacting a cell with an effective amount of a PFKFB4 inhibitor. Short hairpin RNA (shRNA) and small interfering RNA (siRNA) inhibitors of PFKFB4 and their methods of use are also provided. | 10-21-2010 |
| 20100267107 | METHODS FOR ISOLATING VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS - The presently disclosed subject matter provides methods of isolating populations of stem cells that from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject. | 10-21-2010 |
| 20100267075 | MICROFLUIDIC LYSIS - The invention provides methods for isolating and identifying nucleated cells from biological samples using a microfluidic device. | 10-21-2010 |
| 20100233382 | METHOD FOR ELECTROSTATIC DEPOSITION OF GRAPHENE ON A SUBSTRATE - A method for electrostatic deposition of graphene on a substrate comprises the steps of securing a graphite sample to a first electrode; electrically connecting the first electrode to a positive terminal of a power source; electrically connecting a second electrode to a ground terminal of the power source; placing the substrate over the second electrode; and using the power source to apply a voltage, such that graphene is removed from the graphite sample and deposited on the substrate. | 09-16-2010 |
| 20100225337 | CHEMICAL SENSORS FOR DETECTING VOLATILE ORGANIC COMPOUNDS AND METHODS OF USE - The presently-disclosed subject matter provides sensors and methods for detecting volatile organic compounds (VOCs) by determining the conductivity of a chemiresistant film upon exposure to VOCs, including for example chemiresistant films comprised of surfactant-coated metal alloy nanoparticles. | 09-09-2010 |
| 20100224507 | CHEMICAL SENSORS FOR DETECTING HYDROGEN AND METHODS OF USE - The presently-disclosed subject matter provides sensors and methods for detecting hydrogen by determining the conductivity of a chemiresistant film upon exposure to hydrogen, including for example chemiresistant films comprised of alkylamine-, alkylthiolate-, and/or surfactant-coated metal alloy nanoparticles. | 09-09-2010 |
| 20100221280 | PLANT-PRODUCED COMPOSITIONS FOR TREATING PAPILLOMAVIRUS INFECTION AND RELATED METHODS - Compositions for treating papillomavirus (PV) infection in a subject include a PV L2 polypeptide produced from a eukaryotic expression system. | 09-02-2010 |
| 20100201542 | SYSTEM AND METHOD FOR REMOTE SAMPLING OF CONDITIONS USING WIRED SENSORS CONNECTED TO WIRELESS NODES - A system for collecting data includes a remote sensor assembly and a central data collection device. The remote sensor assembly has a data bus, a remote wireless node, and a plurality of remote sensor modules in wired communication with the remote wireless node via the data bus. Each of the remote sensor modules converts a sensed condition into data in response to a request from the remote wireless node. The central data collection device has a master wireless node for periodically wirelessly communicating with the remote wireless node. The remote wireless node collects data from each of the plurality of remote sensor modules and periodically transmits the data to the master wireless node. The remote sensor modules are interchangeable and new remote sensor modules may be added. The remote wireless node may detect the sequence of the attached remote sensor modules to enable three-dimensional mapping of the sensed conditions. | 08-12-2010 |
| 20100166751 | CANCER THERAPY USING WHOLE GLUCAN PARTICLES AND ANTIBODIES - The present invention relates to methods of using whole glucan particles and complement activating antibodies for antitumor therapy. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activating cytokines. | 07-01-2010 |
| 20100151480 | EXOSOME-ASSOCIATED MICRORNA AS A DIAGNOSTIC MARKER - The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more RNAs present in cancer-derived exosomes isolated from a biological sample from the subject. | 06-17-2010 |
| 20100124552 | PEPTIDE BIOMARKERS OF CARDIOVASCULAR DISEASE - The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a biological sample from the subject. The presently-disclosed subject matter further provides methods for determining treatment efficacy and/or progression of a cardiovascular disease in a subject by measuring amounts of one or more of the biomarkers in a biological sample from the subject. The presently-disclosed subject matter also provides antibodies and kits for measuring the biomarkers. | 05-20-2010 |
| 20100112592 | METHODS FOR IDENTIFYING AN INCREASED LIKELIHOOD OF RECURRENCE OF BREAST CANCER - Methods of identifying a mammal having an increased likelihood of recurrence of breast cancer includes identifying in a breast tissue sample of the mammal expression of at least two genes selected from the group consisting of Hs.125867 (EVL), Hs.591847 (NAT1), Hs.208124 (ESR1), Hs.26225 (GABRP), Hs.408614 (ST8SIA1), Hs.480819 (TBC1D9), Hs.504115 (TRIM29), Hs.523468 (SCUBE2), Hs.532082 (IL6ST), Hs.592121 (RABEP1), Hs.79136 (SLC39A6), Hs.82128 (TPBG), Hs.95243 (TCEAL1), Hs.95612 (DSC2), Hs.654961 (FUT8), Hs.1594 (CENPA), Hs.184339 (MELK), Hs.26010 (PFKP), Hs.592049 (PLK1), Hs.370834 (ATAD2), Hs.437638 (XBP1), Hs.444118 (MCM6), Hs.469649 (BUB1), Hs.470477 (PTP4A2), Hs.473583 (YBX1), Hs.480938 (LRBA), Hs.524134 (GATA3), Hs.531668 (CX3CL1), Hs.532824 (MAPRE2), Hs.591314 (GMPS), Hs.83758 (CKS2) and Hs.99962 (SLC43A3) and subsets of the genes. | 05-06-2010 |
| 20100108529 | SENSORS AND SWITCHES FOR DETECTING HYDROGEN - Sensors and switches for detecting hydrogen include an electrically-insulating support; a first and second electrode; and a palladium structure alone or in combination with an organic insulating film. The palladium structures of the sensors are deposited on and contact a first electrode and a portion of the palladium structure extends to and contacts the second electrode to create a conductive path. The palladium structures of the switches are deposited on and contact a first electrode and a portion of the palladium structures extend to and contact an organic insulating film deposited on the second electrode. Upon exposure of the switch to hydrogen, portions of the palladium structure extend through the film and contact the second electrode to create a conductive path. Methods of detecting hydrogen and methods of fabricating a sensor for detecting an analyte of interest are also provided. | 05-06-2010 |
| 20100093100 | PROFILING METHOD USEFUL FOR CONDITION DIAGNOSIS AND MONITORING, COMPOSITION SCREENING, AND THERAPEUTIC MONITORING - The presently-disclosed subject matter includes methods and systems for identifying biomarkers of interest, diagnosing and/or monitoring conditions of interest, assessing the efficacy of a treatment program, and composition screening. Exemplary methods include providing a sample of interest, fractionating the sample, generating thermograms, and comparing thermograms. | 04-15-2010 |
| 20100092524 | MODIFICATION OF EXOSOMAL COMPONENTS FOR USE AS A VACCINE - The presently disclosed subject matter provides modified cell-derived exosomes substantially lacking one or more immunosuppressive polypeptides. The presently-disclosed subject matter further provides methods of producing the modified exosomes and methods of using the modified exosomes for treating cancers. | 04-15-2010 |
| 20100075293 | BIOREACTORS, SYSTEMS, AND METHODS FOR VASCULARIZING TISSUE CONSTRUCTS - A modular bioreactor is provided that includes an upper biochamber; a lower biochamber; and an intermediate biochamber that is positioned between the upper biochamber and the lower biochamber. Each biochamber of the bioreactor is in fluid communication with each other biochamber of the bioreactor and includes an interior wall, which defines a centrally-disposed cavity for each biochamber, and an inflow port and an outflow port that are in fluid communication with each centrally disposed cavity. Systems and methods for vascularizing a tissue construct are also provided. | 03-25-2010 |
| 20100055724 | METHODS OF DETECTING AUTOANTIBODIES FOR DIAGNOSING AND CHARACTERIZING DISORDERS - Methods for detecting and/or quantitating levels of autoantibodies in subjects are provided. Methods for diagnosing and/or characterizing a disorder associated with autoantibody production are further provided. In some embodiments, the disorder diagnosed and/or characterized can be a cancer or an infertility disorder. | 03-04-2010 |
| 20100028407 | LAYERED BIO-ADHESIVE COMPOSITIONS AND USES THEREOF - The invention generally provides compositions and methods for promoting and enhancing wound closure and healing. Specifically, the invention provides a biologic composition which comprises a support layer which serves as transport scaffold, for example made of gelatin, which is coated or impregnated with a bio-adhesive molecule such as rose bengal or glyceraldehyde. The composition can also comprise an artificial or biological matrix, optionally processed (i.e. cleaned and coated with extracellular matrix proteins) to enhance cell attachment and survival. The composition can further comprise a monolayer of epithelial, endothelial cells or mesenchymal cells. The invention provides methods for using the compositions for treating wounds due to disease, trauma or surgery. Specific methods for treating ocular wounds are provided. | 02-04-2010 |
| 20100023012 | DEVICE AND METHOD TO PREVENT HIP FRACTURES - A device for preventing a hip fracture includes: a shaft having a first end and a second end and an expanding means for engaging the femoral head at the first end. The shaft is positioned in a hole of a predetermined depth in a femur. The hole extends from the greater trochanter to the femoral head of the femur, such that the first end is positioned in the femoral head and the second end is positioned in the greater trochanter. The device is oriented substantially perpendicular to the long axis of the femoral shaft. | 01-28-2010 |
| 20090299326 | ENDOVASCULAR ANEURYSM TREATMENT DEVICE AND METHOD - An self-expanding frame is mounted on the distal end of a shaft. The frame is sized and configured so that it can be inserted into the cavity of an aneurysm. Suction is applied to the interior of the aneurysm through the shaft or through another catheter, and the wall of the aneurysm is collapsed onto the exterior surface of the frame. The frame is then collapsed upon further suction being applied to the interior of the aneurysm, which collapses the aneurysm wall with it. The frame folds down on itself, carrying with it the aneurysm wall. The frame is detachable from the shaft and can be left in the collapsed aneurysm. | 12-03-2009 |
| 20090274746 | METHODS AND COMPOSITIONS FOR CONTROLLED DELIVERY OF PHYTOCHEMICAL AGENTS - The presently-disclosed subject matter provides compositions and methods for treating a cancer by providing a composition comprising a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, or a phytochemical agent and a chemotherapeutic agent. Further, provided is a device for uterine cervical insertion for local delivery. | 11-05-2009 |
| 20090258379 | ISOLATION OF MEMBRANE VESICLES FROM BIOLOGICAL FLUIDS AND METHODS OF USING SAME - Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about 0.15 um; and collecting from the filtration module a retentate comprising the membrane vesicles, thereby isolating the membrane vesicles from the biological fluid sample. | 10-15-2009 |
| 20090202621 | CELL-SURFACE DECORATION WITH ACTIVE AGENTS - A lipid vesicle comprising a functionalized lipid comprising a tether moiety having binding affinity for a ligand portion of an active agent and the active agent are provided. Methods of decorating endothelial cells, tissues, and organs with active agents utilizing the disclosed lipid vesicles are also provided. | 08-13-2009 |
| 20090163439 | Methods of using beta glucan as a radioprotective agent - The invention relates to methods for treating and preventing radiation and/or chemotherapy related injury and/or afflictions, such as myelosuppression and decreased macrophage activity, by administering a prophylactically or therapeutically effective amount of particulate, bioavailable β(1,3; 1,6) glucan. The invention also relates to methods in which β(1,3; 1,6) glucan is provided in the form of whole glucan particles, microparticulate β-glucan particles or a combination thereof. | 06-25-2009 |
| 20090081713 | PEPTIDE BIOMARKERS PREDICTIVE OF RENAL FUNCTION DECLINE AND KIDNEY DISEASE - The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease. | 03-26-2009 |
| 20090053816 | HEMOGLOBIN-BASED METHODS FOR PROPHYLAXIS, DIAGNOSIS AND/OR TREATMENT OF RETINAL DISORDERS - The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue. | 02-26-2009 |
| 20090035331 | Systems and Methods for Targeted and Controlled Delivery of Agents - An Agent Delivery System allows for targeted and controlled delivery of an agent or agents to target site, such as specific cells or a specific tissue of an individual. An exemplary Agent Delivery System includes a platform, having a silica crystal lattice base plate, coated with a collagen-containing layer. At least one agent of interest is disposed within the platform, for delivering to the target site. The agent is released when the Agent Delivery Platform is exposed to collagen-degrading compounds. Collagen-degrading compounds can be secreted by cells within a target site. | 02-05-2009 |
| 20090012371 | GENETIC MARKERS OF SCHIZOPHRENIA - The invention includes method of determining if a subject has a genetic predisposition to clinically diagnosed schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD). | 01-08-2009 |
| 20090011996 | DIAGNOSING AND PROTECTING HORSES AGAINST PAPILLOMAVIRUS - Compositions for conferring protection against Equus caballus papillomavirus (EcPV) and Bovine papillomavirus (BPV) infection in a subject are provided and include a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods for protecting a subject against EcPV and BPV infection are further provided and include administering to the subject a composition comprised of a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods of diagnosing EcPV and/or BPV infection in a subject are also provided and include providing a virus-like particle assembled from a papillomavirus L1 protein selected from an EcPV L1 protein and a BPV L1 protein; contacting the virus-like particle with serum from the subject; and identifying the subject as having an infection if an antibody capable of binding the virus-like particle is detected in the serum. | 01-08-2009 |
| 20080312099 | Microarray, System, and Method for Detecting, Identifying, and Quantitating Micro-Rnas - Micro-RNA (miRNA) microarrays useful for detecting, identifying and quantitating miRNAs in a sample include oligonucleotide probes that specifically bind miRNAs. Exemplary miRNA microarray can be specific for miRNAs of human, canine, mouse, rat, or another species. | 12-18-2008 |
| 20080233561 | Method for Measuring Cytopathic Effect Due to Viral Infection in Cells Using Electric Cell-Substrate Impedance Sensing - A method of measuring cytopathic effect in cells includes providing cells in culture, using electric cell-substrate impedance sensing (ECIS) to measure the resistance of current associated with the cells, and quantifying the cytopathic effect (CPE) associated with the cells based on the measured resistance. The cells may be identified as being infected with a virus if the CPE associated with the cells is above a predetermined level. Alternatively, the cells may be provided in a healthy monolayer and infected with a virus in order to measure the effect of the virus on CPE associated with the cells. Cells may also be treated with candidate antiviral agents and the effects of the agents on the virus-infected cells may be measured to screen for and identify actual antiviral agents. | 09-25-2008 |
| 20080221030 | Inhibition of Wet Type Age Related Macular Degeneration (Amd) by Adiponectin or Acrp 30 - The present invention provides new methods of treating wet type of age related macular degeneration by administering adiponectin (APN) or a functional fragment derived therefrom. One of the pathological complications of age related macular degeneration (AMD) is choroidal angiogenesis or choroidal neovascularization (CNV). The inventors discovered that the level of APN expression is significantly lower in the choroids of the laser-induced mouse model of choroidal angiogenesis or choroidal neovascularization (CNV) than that of the control mice and that administration of recombinant adiponectin (rAPN) or a peptide derived from the globular domain of the intact APN protein to the mouse model of CNV reduced the size of CNV significantly. These studies are the first to demonstrate the inhibitory effect of adiponectin on choroidal angiogenesis and thus provide the basis for treating a condition or disease involving angiogenesis, particularly age related macular degeneration, with administration of adiponectin. | 09-11-2008 |
