University of Georgia Research Foundation, Inc. Patent applications |
Patent application number | Title | Published |
20160135349 | Vitex agnus-castus plant named 'V0502-33' | 05-12-2016 |
20160135347 | Vitex agnus-castus plant named 'V07-SC-OP-4' | 05-12-2016 |
20160135345 | Thuja plant named 'RUTTHU#1' | 05-12-2016 |
20160100512 | Pecan tree named 'Tom' - A pecan tree distinguished by the following unique combination of characteristics: high prolificacy, consistent production, early nut maturity, kernel size suited to confection trade, excellent color, absence of kernel speckling, excellent resistance to the scab fungus ( | 04-07-2016 |
20160060638 | PRECURSOR-DIRECTED BIOSYNTHESIS OF 5-HYDROXYTRYPTOPHAN - The invention provides compounds, compositions, non-naturally occurring organisms, and methods useful for production of 5-hydroxytryptophan (5-HTP) in a microbial cell. A microbial system which includes at least one microbial cell, such as a bacterial cell or a yeast cell, is genetically engineered to express all or a portion of non-naturally occurring biosynthetic pathway that catalyzes the conversion of a simple carbon source, such as glucose, to 5-HTP. The invention can result in improved titers of 5-HTP and permits low-cost, large scale production. Methods of making and using the genetically engineered cells are also included in the invention. | 03-03-2016 |
20160022825 | NANOPARTICLES FOR MITOCHONDRIAL TRAFFICKING OF AGENTS - Nanoparticles include a core, a hydrophilic layer around the core, and one or more mitochondrial targeting moieties, and may optionally include one or more contrast agents or one or more therapeutic agents. For effective mitochondrial targeting the nanoparticles have a diameter of about 200 nm or less or have a zeta potential of about 0 mV or more. | 01-28-2016 |
20150313055 | Ornamental perennial peanut 'PP-1' - The new cultivar of | 10-29-2015 |
20150225758 | GENETICALLY MODIFIED CELLS AND METHODS FOR MAKING ACTIVATED SUGAR-NUCLEOTIDES - This disclosure generally relates to genetically engineered cells and methods of making and using such genetically engineered cells. Generally, the genetically engineered cells exhibit an increase in synthesis of an activated sugar-nucleotide compared to a wild type control. In some embodiments, the activated sugar-nucleotide produced by the genetically engineered cell is an activated sugar-nucleotide that is not natively synthesized by wild type, un-engineered cell. In some embodiments, the activated sugar-nucleotide is an activated uridine diphosphate sugar nucleotide. In other embodiments, the activated sugar-nucleotide is an activated cysteine monophosphate sugar nucleotide. In still other embodiments, the activated sugar-nucleotide is an activated guanosine diphosphate sugar nucleotide. In some embodiments, the activated sugar-nucleotide includes an isotopic label. | 08-13-2015 |
20150225751 | MICROBIAL PRODUCTION OF MUCONIC ACID AND SALICYLIC ACID - The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements. | 08-13-2015 |
20150184205 | BIOSYNTHESIS OF CAFFEIC ACID AND CAFFEIC ACID DERIVATIVES BY RECOMBINANT MICROORGANISMS - Microorganisms are genetically engineered to synthesize caffeic acid from simple carbon sources via a tyrosine intermediate by means of a dual pathway that utilizes both endogenous and engineered enzymatic activities. | 07-02-2015 |
20150140331 | NANOPARTICLES AND METHOD OF MAKING NANOPARTICLES - Embodiments of the present disclosure include metal boride nanoparticles, methods of making metal boride nanoparticles, methods of using metal boride nanoparticle, metal oxide nanoparticles, methods of making metal oxide nanoparticles, methods of using metal oxide nanoparticle, and the like. | 05-21-2015 |
20150087806 | GLYCOPEPTIDE AND USES THEREOF - A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof. | 03-26-2015 |
20150079036 | Spiro[2.4]heptanes for Treatment of Flaviviridae Infections - Compounds, methods, and compositions for the treatment of infections in or exposure to humans and other host animals of Flaviviridae viruses, including HCV, that includes the administration of an effective amount of a spiro[2.4]heptane as described herein or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier, are provided. The spiro[2.4]heptane compounds either possess antiviral activity, or are metabolized to a compound that exhibits such activity. | 03-19-2015 |
20150038419 | SIMUKUNIN - The present invention includes a novel protein, also referred to herein as simukunin, that inhibits the function of several physiologically important enzymes. Simukunin is a potent inhibitor of the blood coagulation cascade, inhibiting Factor Xa and functioning as an efficient anticoagulant. Simukunin also inhibits the serine proteases elastase and cathepsin and demonstrates anti-inflammatory properties. Also included are methods of making and using simukunin. | 02-05-2015 |
20150026849 | Pecan tree named 'HUFFMAN' - A pecan tree distinguished by the following unique combination of characteristics: Consistent and acceptable fruit production, small fruit cluster, moderately early nut maturity, large nut producing mammoth kernels with good color and no observed speckling, and no observed scab fungus. | 01-22-2015 |
20150026848 | Pecan tree named 'TREADWELL' - A pecan tree distinguished by the following unique combination of characteristics: high precociousness and prolificacy, consistent production (if fruit thinned), early nut maturity, large nut size that produces mammoth halves, unusual high percentage kernel, exceptional kernel color, no kernel speckling has been observed, high resistance to N scorch, black pecan aphid, pecan leaf scorch mite, and good resistance to scab fungus. | 01-22-2015 |
20140363868 | TRANSGENIC PLANTS AND METHODS OF USING SAME - Provided herein are plants having altered expression of a coding region encoding a hydroxyproline-rich glycoprotein. In some embodiments the expression is decreased, and the resulting plant has decreased recalcitrance, increased growth, or a combination thereof. In some embodiments the expression is increased, and the resulting plant has decreased growth, biomass that is more cross-linked, biomass that is more dense, or a combination thereof. Also provided are methods for making and using such plants. | 12-11-2014 |
20140363467 | AVIAN INDUCED PLURIPOTENT STEM CELLS AND THEIR USE - The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lin28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring. | 12-11-2014 |
20140341950 | RECOMBINANT AVIAN PARAMYXOVIRUS VACCINE AND METHOD FOR MAKING AND USING THEREOF - The present invention encompasses engineered APMV compositions or vaccines. The vaccine or composition may be a recombinant APMV composition or vaccine. The present invention encompasses methods for modifying the genome of APMV to produce recombinant APMV; modified APMV prepared by such methods; DNA and protein sequences; and methods for infecting cells and host animals with such recombinant APMV. | 11-20-2014 |
20140331363 | PLANTS WITH ALTERED GLUCURONOXYLAN METHYL TRANSFERASE ACTIVITY AND METHODS OF USE - Provided herein are plants having altered glucuronoxylan methyl transferase (GXMT) activity, including reduced GXMT activity. In one embodiment the plant is a transgenic plant. Also provided herein are methods for using such plants, including methods for processing a part of a plant to result in a pulp, methods for hydrolyzing a pulp, and methods for producing a metabolic product. Further provided herein is plant material from a plant having altered GXMT activity, and pulp from a plant having altered GXMT activity. | 11-06-2014 |
20140315212 | ALPHA TOXIN DETECTION OF GPI ANCHORED PROTEINS - The present invention relates to a method for the purification, concentration and identification of glycosylphosphatidylinositol anchored proteins (GPI-APs) from a biological sample (cells, tissues and/or blood/serum) in a patient or subject, including a human patient or subject. A new method to separate GPI-anchored glycoproteins, a class of glycoproteins found in all animal cells and fluids including serum, from other glycoproteins and proteins for the purpose of identifying potential biomarkers for various diseases, including cancer, especially breast cancer, vaginal cancer, endometrial cancer, uterine cancer, cervical cancer, pancreatic cancer and prostate cancer. The method uses the alpha-toxin from | 10-23-2014 |
20140308700 | HYDROGENASE POLYPEPTIDE AND METHODS OF USE - Provided herein are polypeptides having hydrogenase activity. The polypeptide may be multimeric, and may have hydrogenase activity of at least 0.05 micromoles H | 10-16-2014 |
20140302609 | POLYDNAVIRUS DELIVERY CONSTRUCTS - Provided herein are methods of producing a genetically modified cell by introducing a polydnavirus delivery construct to a target cell. The polydnavirus delivery construct can comprise an exogenous nucleic acid to form a genetically modified cell comprising the exogenous nucleic acid. Also provided are polydnavirus delivery constructs comprising an exogenous nucleic acid, as well as polydnavirus virions and genetically modified cells comprising the same. Further provided are in vitro methods of identifying a transformed cell. The methods comprise introducing a vector comprising a nucleotide sequence encoding a glc polypeptide to an adherent cell and cultivating the cell under conditions that allow for the expression of the glc polypeptide. Expression of the glc polypeptide results in a transformed cell that is identified by a loss of adherency. | 10-09-2014 |
20140283252 | Hydrangea Macrophylla Plant Named 'Bountiful Bouquets' - A new and distinct cultivar of | 09-18-2014 |
20140283251 | Hydrangea macrophylla plant named 'show stopper' - A new and distinct cultivar of | 09-18-2014 |
20140275213 | Methods and Compositions for Plant Pest Control - The present invention comprises methods and compositions for controlling nematode parasitism in host plant. The present invention comprises novel polynucleotides and polypeptides encoded by such polynucleotides comprising one or more nucleic acid sequences disclosed herein having a nucleotide sequence comprising any one of SEQ ID NOs: 1-142, a fragment or variant thereof, or a complement thereof, or a polypeptide sequence comprising any one of SEQ ID NOs: 143-159, a fragment or variant thereof. | 09-18-2014 |
20140259207 | Methods to Identify Soybean Aphid Resistant Quantitative Trait Loci in Soybean and Compositions Thereof - The present invention is in the field of plant breeding and aphid resistance. More specifically, the invention includes a method for breeding soybean plants containing quantitative trait loci that are associated with resistance to aphids, | 09-11-2014 |
20140255900 | DUAL TASK MENTAL DEFICIENCY ASSESSMENT SYSTEMS AND METHODS - Systems and methods for simultaneously conducting a non-reflex motor test and a cognitive test are described herein. This dual-test methodology compares a baseline performance for an individual to a diagnostic performance for the individual to determine whether an individual has suffered a concussion or other mental deficiency. The baseline performance data is collected before a suspected injury, and the diagnostic performance data is collected after the suspected injury. The methodology may also be used to determine how an individual is recovering from a concussion or mental deficiency by comparing later performances to earlier performances. | 09-11-2014 |
20140248687 | METHODS FOR EXPRESSING POLYPEPTIDES IN HYPERTHERMOPHILES - Provided herein are genetically engineered archaea. A genetically engineered archaea includes a heterologous polynucleotide that has a promoter operably linked to a coding region, where the coding region encodes a polypeptide having optimal activity below the optimum growth temperature (T | 09-04-2014 |
20140248635 | ALPHA-TUBULIN ACETYLTRANSFERASE - Polypeptides with tubulin acetyltransferase activity are described, as are nucleic acids encoding said polypeptides, and methods of use. The invention further provides enhancers and inhibitors of tubulin acetyltransferase activity, as well as cells having altered tubulin transferase activity. | 09-04-2014 |
20140221487 | Use Of Xanthophyll Carotenoids To Improve Visual Performance And Neural Efficiency - In one embodiment, the invention provides a method of enhancing a subject's macular pigment optical density, the method comprising administering to the subject a pharmaceutically effective amount of one or more Xanthophyll carotenoids. Preferably, the Xanthophyll carotenoids are selected from the group consisting of lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ), and enantiomers, metabolites, esters, pharmaceutically acceptable salts and derivatives thereof. In certain embodiments, the Xanthophyll carotenoids such as lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) are each in substantially pure enantiomeric form. | 08-07-2014 |
20140212473 | GLYCOPEPTIDE AND USES THEREOF - A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof. | 07-31-2014 |
20140170724 | REPLICATING EXPRESSION VECTOR AND METHODS - This disclosure provides a shuttle vector for transferring genetic material between | 06-19-2014 |
20140154710 | GLYCOPROTEIN CANCER BIOMARKER - The invention relates to glycoproteins having a cancer-specific glycoform. Cancer-specific glycoforms are useful in diagnostics and therapeutics. | 06-05-2014 |
20140147473 | Functional Nanostructured "Jelly Rolls" with Nanosheet Components - The present disclosure relates to multilayered materials that are designed to roll spontaneously into micron-sized, cylindrical “jelly roll” or scroll structures. Specifically in this disclosure, at least one of the layers is comprised of a nanosheet material. | 05-29-2014 |
20140140958 | Spiro[2.4]heptanes for Treatment of Flaviviridae Infections - Compounds, methods, and compositions for the treatment of infections in or exposure to humans and other host animals of Flaviviridae viruses, including HCV, that includes the administration of an effective amount of a spiro[2.4]heptane as described herein or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier, are provided. The spiro[2.4]heptane compounds either possess antiviral activity, or are metabolized to a compound that exhibits such activity. | 05-22-2014 |
20140140957 | Spiro[2.4]heptanes for Treatment of Flaviviridae Infections - Compounds, methods, and compositions for the treatment of infections in or exposure to humans and other host animals of Flaviviridae viruses, including HCV, that includes the administration of an effective amount of a spiro[2.4]heptane as described herein or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier, are provided. The spiro[2.4]heptane compounds either possess antiviral activity, or are metabolized to a compound that exhibits such activity. | 05-22-2014 |
20140134690 | MICROBES AND METHODS FOR PRODUCING 1-PROPANOL - Provided herein are microbes metabolically engineered to produce 1-propanol from a 1,2-propanediol intermediate. The microbes may include one or two pathways for production of 1-propanol from a 1,2-propanediol intermediate. Also provided herein are methods for using the microbes for the production of 1-propanol. | 05-15-2014 |
20140120592 | RECOMBINANT CALDICELLULOSIRUPTOR BESCII AND METHODS OF USE - This disclosure describes recombinant | 05-01-2014 |
20140106341 | STABILIZED BIOACTIVE PEPTIDES AND METHODS OF IDENTIFICATION, SYNTHESIS, AND USE - An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues. | 04-17-2014 |
20140099665 | Paenibacillus Spp. and Methods for Fermentation of Lignocellulosic Materials - Provided herein are methods for producing a fermentation product, such as ethanol, by co-culture of a member of the genus | 04-10-2014 |
20140097838 | SPLIT BIRDCAGE COIL, DEVICES, AND METHODS - This disclosure describes, in one aspect, a device that includes a dual-tuned birdcage coil. The dual-tuned birdcage coil generally includes an inner multinuclear coil and a plurality of outer | 04-10-2014 |
20140093941 | PROKARYOTIC RNAi-LIKE SYSTEM AND METHODS OF USE - Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5′ region and a 3′ region. The 5′ region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3′ region is substantially complementary to a portion of the target polynucleotide. The methods may be practiced in a prokaryotic microbe or in vitro. Also provided are polypeptides that have endonuclease activity in the presence of a psiRNA and a target polynucleotide, and methods for using the polypeptides. | 04-03-2014 |
20140072790 | METAL SILICATE NANOSHEETS, METHODS OF MAKING METAL SILICATE NANOSHEETS, AND METHODS OF USE - Embodiments of the present disclosure relate to the preparation of colloidal dispersions or suspensions of inorganic materials with nano-sized and nano-structured morphologies, preferably the nanosheet form, compositions produced by this method, and the like. | 03-13-2014 |
20140068815 | Sorghum Maturity Gene and Uses Thereof in Modulating Photoperiod Sensitivity - Compositions relating to the sorghum maturity gene 1 (Ma1) and expression control sequences and methods of use thereof are provided. The compositions can be used to modulate flowering and photoperiod sensitivity in a plant. For example, methods are provided for developing genetically modified plant varieties in which flowering is accelerated, delayed or prevented. Methods are provided for treating a plant in order to delay flowering in the plant. Methods of placing a polynucleotide of interest, such a gene, under photoperiod sensitive control or photoperiod insensitive control are also provided. Screening methods are for identifying chemical agents that can modify photoperiod sensitivity are also disclosed. | 03-06-2014 |
20140054163 | METHODS FOR REACTING CYSTEINE RESIDUES IN PEPTIDES AND PROTEINS - Methods for labeling or modifying cysteine residues in proteins and/or enzymes are disclosed. The methods include the reaction of an o-naphthoquinone methide with a thiol group of a cysteine residue of a protein or enzyme, which can be reversible in preferred embodiments. The o-naphthoquinone methide can conveniently be generated by irradiation of a precursor compound, preferably in an aqueous solution, suspension, or dispersion. | 02-27-2014 |
20140051603 | COMPOUNDS AND METHODS FOR CHEMICAL AND CHEMO-ENZYMATIC SYNTHESIS OF COMPLEX GLYCANS - The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans. | 02-20-2014 |
20140011987 | Synthetic Lipid A Derivative - The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative. | 01-09-2014 |
20140010840 | RECOMBINANT MUMPS VIRUS VACCINE - The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuV | 01-09-2014 |
20140004588 | METHODS AND COMPOSITIONS FOR DEGRADING PECTIN | 01-02-2014 |
20130326736 | NEMATODE RESISTANT CROPS - Methods of inhibiting plant parasitic nematodes, methods of obtaining transgenic plants useful for inhibiting such nematodes, and transgenic plants that are resistant to plant parasitic nematodes through inhibition of plant nematode CLE peptide receptor genes are provided. Methods for expressing genes at plant parasitic nematode feeding sites with plant nematode CLE peptide receptor gene promoters are also provided, along with nematode CLE peptide receptor gene promoters that are useful for expressing genes in nematode feeding sites as well as transgenic plants and nematode resistant transgenic plants comprising the promoters. | 12-05-2013 |
20130291229 | MODIFICATION OF SUCROSE DISTRIBUTION IN PLANTS - The present invention provides transgenic plant and methods of using them. In one embodiment, the methods include growing a transgenic plant under certain conditions, such as stress conditions, such as drought, heat, or salt, where the plant has decreased expression of a SUT polypeptide compared to a control plant. The transgenic plant may have a phenotype of increased growth, increased formation of woody tissue, increased drought tolerance, increased water use efficiency, increased nitrogen utilization efficiency, or a combination thereof, compared to the control plant. In another embodiment, the methods include using a transgenic plant to produce a pulp. | 10-31-2013 |
20130289588 | VASCULAR CLIP - The present disclosure provides a clip for application to a renal artery to induce hypertension. The clip includes a pair of arms between which is formed a slot. The arms are supported by a base portion. The clip may include various curved surfaces to prevent snagging and damage when applied to the renal artery. Also, the clip is preferably constructed of stock titanium rods to have a unitary and stiff construction. Further, the clip includes a pair of cylindrical suture openings that retain a suture passed therethrough after the clip is applied to the renal artery. The suture firmly retains the clip on the artery. | 10-31-2013 |
20130274573 | Systems And Methods For Measuring Mitochondrial Capacity - In one embodiment, measuring mitochondrial capacity includes performing arterial occlusions on a patient, measuring oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin within the patient's body during the occlusions, calculating a blood volume correction factor that accounts for a change in blood volume that occurs during the arterial occlusions, and applying the correction factor to the measured oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements to obtain correct oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements. | 10-17-2013 |
20130244309 | Algal Floway (AGF) System for Economical and Efficient Harvesting of Algal Biomass and Method of Use - The present disclosure includes algal floway (AGF) systems for continuous, specific, economical, and efficient harvesting of algae biomass. | 09-19-2013 |
20130224152 | Spiro[2.4]heptanes for Treatment of Flaviviridae Infections - Compounds, methods, and compositions for the treatment of infections in or exposure to humans and other host animals of Flaviviridae viruses, including HCV, that includes the administration of an effective amount of a spiro[2.4]heptane as described herein or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier, are provided. The spiro[2.4]heptane compounds either possess antiviral activity, or are metabolized to a compound that exhibits such activity. | 08-29-2013 |
20130195910 | VACCINE DELIVERY METHOD - The present invention includes a composition including as one component a slurry matrix that is a liquid at room temperature and a gel at physiological pH, physiological salt concentrations and/or physiological temperatures and as a second component one or more antigens. Also include are methods of inducing an immune response in a subject and vaccinating a subject by administering such compositions. | 08-01-2013 |
20130189375 | BIOCIDAL IRON OXIDE COATING, METHODS OF MAKING, AND METHODS OF USE - Embodiments of the present disclosure include visible light antimicrobial materials comprising α-Fe | 07-25-2013 |
20130160155 | Methods to Identify Soybean Aphid Resistant Quantitative Trait Loci in Soybean and Compositions Thereof - The present invention is in the field of plant breeding and aphid resistance. More specifically, the invention includes a method for breeding soybean plants containing quantitative trait loci that are associated with resistance to aphids, | 06-20-2013 |
20130129780 | MODIFIED INFECTIOUS LARYNGOTRACHEITIS VIRUS (ILTV) AND USES THEREOF - Provided herein are modified infectious largotracheitis viruses (ILTVs) and methods of using the same. For example, provided are attenuated ILTVs. The attenuated ILTVs can be used to illicit immune responses in avian species. Optionally, the attenuated ILTVs can be used to vaccinate an avian subject or a population of avian subjects. Optionally, an attenuated ILTV is administered in ovo to an avian egg. One or more such in ovo administration can be used to increase the immunity of an avian herd. | 05-23-2013 |
20130128265 | THIN LAYER CHROMATOGRAPHY-SURFACED ENHANCED RAMAN SPECTROSCOPY CHIPS AND METHODS OF USE - The present disclosure includes methods of simultaneous analyte separation and detection using surface enhanced Raman spectroscopy (SERS)-active ultra thin layer chromatography (UTLC) chips. The SERS-active UTLC chips of the present disclosure are used to physically separate compounds within a mixture, which are then identified based on their unique SERS spectra. | 05-23-2013 |
20130121989 | ALPHA-TUBULIN ACETYLTRANSFERASE - Polypeptides with tubulin acetyltransferase activity are described, as are nucleic acids encoding said polypeptides, and methods of use. The invention further provides enhancers and inhibitors of tubulin acetyltransferase activity, as well as cells having altered tubulin transferase activity. | 05-16-2013 |
20130102022 | PLANTS WITH ALTERED CELL WALL BIOSYNTHESIS AND METHODS OF USE - Provided herein are plants having altered expression of a GAUT polypeptide. Such plants have phenotypes that may include decreased recalcitrance, increased growth, decreased lignin content, or a combination thereof. Also provided herein are methods of making and using such plants. | 04-25-2013 |
20130081158 | Sorghum Grain Shattering Gene and Uses Thereof in Altering Seed Dispersal - Compositions and methods relating to identification of the sorghum grain shattering gene (Sh1) for use in modulating fruit dehiscence in a plant are provided. For example, methods are provided for developing genetically modified plant varieties in which the natural seed dispersal process is delayed. Likewise, methods are provided for treating a plant in order to delay fruit dehiscence in the plant. Screening methods are also provided for identifying chemical agents that can modify natural seed dispersal. | 03-28-2013 |
20130078281 | ACTIVATORS OF INNATE IMMUNITY - The present invention includes IFNS activating agents that activate expression of IFN-β, activate NF-κB expression, activate an innate immune response, activate the expression of one or more cytokines, and/or induce the expression of interferon beta (IFN-β) through a RNase L and/or MDA5-dependent pathway. Such IFNS activating agents include single stranded RNAs that encode for conserved region II of the L protein of a negative stranded RNA virus, including, but not limited to, viruses of the family Paramyxoviridae. Also included are methods of making and using such IFNS activating agents and compositions and kits including such IFNS activating agents. | 03-28-2013 |
20130072484 | TYROSINE KINASE INHIBITORS AS ANTI-KINETOPLASTID AND ANTI-APICOMPLEXAN AGENTS - The present invention provides methods of killing, inhibiting the growth, and/or inhibiting the reproduction of kinetoplastid or apicomplexan protozoan with tyrosine kinase inhibitors. | 03-21-2013 |
20130045512 | MICROBIAL PRODUCTION OF PYRUVATE AND OTHER METABILITES - Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a carbon sources. | 02-21-2013 |
20130041592 | Method And System Using Computer Simulation For The Quantitative Analysis Of Glycan Biosynthesis - This invention provides a quantitative analysis of glycan biosynthesis along meta pathways using computer simulation for comparing a computer generated spectrum to experimental data to quantitatively track the biosynthesis. Computer simulating the mass spectra of isotopic detection of aminosugars with glutamine experiments allows modeling the glycan biosynthesis over time, via changes in the | 02-14-2013 |
20130040380 | BIOLOGICAL OPTIMIZATION SYSTEMS FOR ENHANCING PHOTOSYNTHETIC EFFICIENCY AND METHODS OF USE15 - The present disclosure relates to biological optimization systems for enhancing photosynthetic efficiency and methods of use. | 02-14-2013 |
20130031671 | PLANT ARTIFICIAL CHROMOSOMES AND METHODS OF MAKING THE SAME - An engineered centromere, and systems and methods of using the engineered centromere are described. The engineered centromere can have tandem repeats of a DNA sequence with binding motifs to permit binding of fusion proteins that include a DNA binding protein and a kinetochore protein to activate the engineered centromere. Also described are a plant artificial chromosome that includes the engineered centromere, a transgenic plant containing the engineered chromosome, and a method of synthesizing a large molecule by adding multiple genes using the plant artificial chromosome. | 01-31-2013 |
20130005677 | 2'-FLUORO-6'-METHYLENE CARBOCYCLIC NUCLEOSIDES AND METHODS OF TREATING VIRAL INFECTIONS - The present invention relates to 2′-Fluoro-6′-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses. | 01-03-2013 |
20120327407 | Independent Component Analysis of Surface-Enhanced Raman Scattering (SERS) Signals - Embodiments of the present disclosure, in one aspect, relate to methods of analyzing SERS signals, systems for analyzing SERS signals, in particular, using an independent component analysis, and the like. | 12-27-2012 |
20120322974 | ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS - 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate. | 12-20-2012 |
20120316209 | DIAGNOSTIC ASSAY FOR TRYPANOSOMA CRUZI INFECTION - A sensitive, multicomponent diagnostic test for infection with | 12-13-2012 |
20120308991 | SUBSTRATE-SELECTIVE CO-FERMENTATION PROCESS - Biological method for conversion of a sugar-containing organic material into a desired biochemical product. Use of a plurality of substrate-selective cells allows different sugars in a complex mixture to be consumed concurrently and independently. The method can be readily extended to remove inhibitory compounds from hydrolysate. | 12-06-2012 |
20120288762 | GRAPHENE-COATED PYROLYTIC CARBON STRUCTURES, METHODS OF MAKING, AND METHODS OF USE THEREOF - Embodiments of the present disclosure provide for flexible graphene-coated pyrolytic carbon materials or structures, methods of making, methods of use, materials including the graphene-coated pyrolytic carbon material or structure, structures including the graphene-coated pyrolytic carbon material or structure, and the like. | 11-15-2012 |
20120284887 | Viburnum plant name 'PIIVIB-I' - A new and distinct cultivar of | 11-08-2012 |
20120284885 | Distylium plant named 'PIIDIST-I' - A new and distinct cultivar of | 11-08-2012 |
20120284884 | Distylium plant named 'PIIDIST-II' - A new and distinct cultivar of | 11-08-2012 |
20120284883 | DISTYLIUM PLANT NAMED 'VINTAGE JADE' - A new and distinct cultivar of | 11-08-2012 |
20120282218 | PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS - New chiral and achiral oxy-substituted cyclopentyl pyridinone diketocarboxamides and their derivatives and methods for their preparations are disclosed. The compounds include tautomers, regioisomers and geometric isomers. These complex carboxamides are designed as inhibitors of HIV replication through inhibition of HIV integrase. The compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents, especially other anti-HIV compounds (including other anti-HIV integrase agents), which can be used to create combination anti-HIV cocktails. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described. | 11-08-2012 |
20120267810 | DEVICES AND METHODS FOR FORMING NON-SPHERICAL PARTICLES - Embodiments of the present disclosure provide for devices, methods for forming non-spherical particles, and the like. | 10-25-2012 |
20120264760 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections - One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of | 10-18-2012 |
20120251564 | REOVIRUS COMPOSITIONS AND METHODS OF USE - The present invention relates to novel strains of avian reovirus isolated from severe cases of Runting Stunting Syndrome in young broiler chickens in southeast United States. The invention is directed to avian reoviruses that impair digestion in poultry, diagnostic assays using nucleotide- or amino acid-specific components of such viruses, and to vaccines that protect chickens from disease caused by such viruses. Nucleotide sequences for the S1 gene, encoding the sigma C minor outer capsid protein, were amplified, and the nucleotide and predicted amino acid sequences were compared with sequences from other recently isolated reovirus field isolates and vaccine strains. Antigenic and molecular characterization of the newly isolated reoviruses revealed a lack of homogeneity with current U.S. isolates, with less than 60% percent amino acid similarity across the sigma C protein. Sequence comparisons with previously reported malabsorption isolates from Europe and Asia revealed a higher amino acid similarity, approaching 80%. | 10-04-2012 |
20120233731 | Hydrangea paniculata plant named 'PIIHP-I' - A new and distinct cultivar of | 09-13-2012 |
20120210479 | Crapemyrtle plant named 'GAMAD IX' - A new and distinct cultivar of crapemyrtle, ‘GAMAD IX’, is provided. ‘GAMAD IX’ is a | 08-16-2012 |
20120193578 | NEAR INFRARED DOPED PHOSPHORS HAVING A ZINC, GERMANIUM, GALLATE MATRIX - Phosphors based on transition metal-activated gallates, particularly Cr | 08-02-2012 |
20120191379 | IMPACT SENSING AND RECORDING - Various methods and systems are provided for impact sensing and recording. In one embodiment, an impact recording sensor includes an impulse sensing system configured to sense impacts experienced by the impact recording sensor in three dimensions and a microcontroller unit (MCU) configured to obtain impact data from the impulse sensing system and store an impact data set including the impact data in memory in response to an impact experienced by the impact recording sensor. The impact recording sensor may also include a rechargeable power source configured to supply power to the MCU. In another embodiment, an impact recording system includes and impact recording sensor and a control interface unit configured to communicatively couple with the impulse recording sensor. The control interface unit may be configured to download impact data set stored in memory of the impulse recording sensor. | 07-26-2012 |
20120189657 | MICROBIAL VACCINE AND VACCINE VECTOR - The present invention includes cold-adapted, acid-fast bacterium for use as a vaccine and a vaccine vector. In preferred embodiments, the cold-adapted, acid-fast bacterium is a | 07-26-2012 |
20120172575 | ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS - 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate. | 07-05-2012 |
20120142560 | HEPARAN SULFATE SYNTHESIS - The invention provides an efficient modular chemical synthesis for heparan sulfate oligosaccharides based on orthogonal protection strategies. Modular disaccharide building blocks, themselves the product of a novel combinatorial synthesis, are combined in numerous ways to produce a range of oligosaccharides. | 06-07-2012 |
20120129928 | Chlorine-Free Liquid Microbicide Treatment - The combination of the surfactant SDS with levulinic acid produces a synergistic effect in relation to the antimicrobial effectiveness of the individual compounds. Accordingly, this surprising synergy allows the formulation of compositions wherein the active agents are present at concentrations effective to reduce bacterial counts in liquids, including, but not limited to, water and other beverages, especially those having a pH value less than about 7.0 by a factor between 10 | 05-24-2012 |
20120121679 | VIRICIDAL AND MICROBICIDAL COMPOSITIONS AND USES THEREOF - The present disclosure encompasses compositions comprising a surfactant, and an acid such as, but not limited to, levulinic acid, that together have a synergistic effect in reducing the viability of a virus population compared to the efficacy of the individual compounds. This synergy allows the formulation of compositions where the active agents (including an acid and a surfactant) are present at concentrations effective to inactivate viruses on surfaces, including human skin. The viricidal compositions disclosed herein are efficacious without damaging the surface to which they may be applied, or even altering the organoleptic properties of a treated food substance. The viricidal compositions and wipes containing such compositions are suitable for sanitizing any surface suspected of having a viral load thereon, or where it is desirable to ensure that a viral load is as low as possible. | 05-17-2012 |
20120110710 | PUNICA GRANATUM PLANT NAMED 'ORANGE BLOSSOM SPECIAL' - A new and distinct cultivar of | 05-03-2012 |
20120094347 | METHODS AND COMPOSITIONS FOR DEGRADING PECTIN - The present invention provides enriched polynucleotides, and enriched polypeptides having pectinase activity. The present invention also includes methods of using the polynucleotides and polypeptides described herein. For instance, the methods include producing a metabolic product, such as ethanol. | 04-19-2012 |
20120079764 | METHODS AND COMPOSITIONS USING FUNGAL LACCASES TO REDUCE TURF THATCH - The present disclosure describes methods and compositions for reducing turf thatch and/or preventing turf thatch buildup. | 04-05-2012 |
20120071553 | CHLORINE-FREE WATER TREATMENT - A combination of the surfactant SDS with levulinic acid produces a synergistic effect in relation to the antimicrobial effectiveness of the individual compounds, allowing the formulation of compositions wherein the active agents are present at concentrations effective to reduce bacterial and fungal counts in liquids, including, but not limited to, water and other beverages, without altering the organoleptic properties of the treated food substance. The active agents are FDA-approved as food additives, and the treated beverages can be any aqueous-based beverage consumable by humans or animals. The levulinic acid-SDS combination is also suitable for reducing or eliminating the microbial population on the surfaces of water and beverage containers, and the machinery and facilities for the bottling of liquids. | 03-22-2012 |
20120070490 | ANTI-TRYPANOSOMAL PEPTIDES AND USES THEREOF - The present invention provides methods of killing, inhibiting the growth, and/or inhibiting the reproduction of kinetoplastid protozoan with hydrophobic signal sequence peptides and compositions including such hydrophobic signal sequence peptides. | 03-22-2012 |
20120059145 | STABILIZED BIOACTIVE PEPTIDES AND METHODS OF IDENTIFICATION, SYNTHESIS, AND USE - An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues. | 03-08-2012 |
20120058960 | FEEDBACK PRODRUG - Compounds and methods for use in selectively inhibiting a lytic enzyme based on feedback inhibition are described. The conjugated compound serves as a substrate for a lytic enzyme. Cleavage of the conjugated compound by the lytic enzyme releases an inhibitor of the enzyme. | 03-08-2012 |
20120040011 | ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS - 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate. | 02-16-2012 |
20120039984 | GLYCOPEPTIDE AND USES THEREOF - A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof. | 02-16-2012 |
20120021005 | MYCOPLASMA GALLISEPTICUM FORMULATION - The present invention provides a formulation that prevents virulent | 01-26-2012 |
20120014962 | METHOD OF INHIBITING FIBROGENESIS AND TREATING FIBROTIC DISEASE - The present invention relates to the discovery of an epigenetic relay pathway that controls hepatic stellate cell activation and the wound-healing response in fibrogenesis, including fibrogenesis of the injured liver. Methods of inhibiting fibrogenesis, including liver fibrogenesis and secondary disease states and conditions thereof, and in treating liver damage, including cirrhosis of the liver (which may be caused by viruses or chemicals, including alcohol), are aspects of the present invention. The methods utilize certain nucleoside compounds and/or antibodies which are optionally conjugated. Pharmaceutical compositions represent additional aspects of the invention. | 01-19-2012 |
20110305672 | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME - The present invention relates to inter alia, methods for the generation and maintenance of Mesoderm-derived ISL1+ Multipotent Progenitors (IMPs), the production of a number of pluripotent cells including and epicardial pluripotent cells (EPCs) and using these cells to produce endothelial cells, cardiomyocytes, smooth muscle cells, vascular cells and other cells and related methods as otherwise disclosed herein. The invention also relates to compositions comprising a population of cells. | 12-15-2011 |
20110296572 | Lagerstroemia plant named 'PIILAG-III' - A new and distinct cultivar of | 12-01-2011 |
20110296570 | Lagerstroemia plant named 'PIILAG-II' - A new and distinct cultivar of | 12-01-2011 |
20110284798 | WHITE PHOSPHORS, METHODS OF MAKING WHITE PHOSPHORS, WHITE LIGHT EMITTING LEDS, METHODS OF MAKING WHITE LIGHT EMITTING LEDS, AND LIGHT BULB STRUCTURES - Phosphor compositions, white phosphor compositions, methods of making white phosphor compositions, tinted white phosphor compositions, methods of making tinted white phosphor compositions, LEDs, methods of making LEDs, light bulb structures, paints including phosphor compositions, polymer compositions including phosphor compositions, ceramics including phosphor compositions, and the like are provided. | 11-24-2011 |
20110280807 | Methods and Models for Stress-Induced Analgesia - The invention disclosed relates to methods and models for enhancing stress-induced analgesia through non-opioid mechanisms. | 11-17-2011 |
20110263487 | Plant Production and Delivery System for Recombinant Proteins as Protein-Flour or Protein-Oil Compositions - The present invention relates to a plant flour material comprising a ground, dried plant material, wherein the plant material contains a recombinant protein comprises a bactericidal or an insecticidal protein toxin, or combinations thereof. The present invention further relates to a seed oil body composition comprising a seed oil body fusion, said oil body fusion comprising an oil body protein fused to a recombinant protein comprising a bactericidal or an insecticidal protein toxin. The present invention provides for a method of abating or controlling the population of mosquitoes comprising administering to a water source suspected of containing mosquito larvae an effective amount of seed oil body preparation comprising one or more Bti toxins, optionally in combination with one or more BtBs. Additionally, the present invention provides for a method of controlling or abating a pathogenic microbial population comprising administering to an insect population, which serves as a host for the pathogenic microbial population, a recombinant plant material containing a recombinant protein comprising an bactericidal protein toxin. | 10-27-2011 |
20110217739 | CAS6 POLYPEPTIDES AND METHODS OF USE - Provided herein are methods for cleaving a target RNA polynucleotide. The target RNA polynucleotide includes a Cas6 recognition domain and a cleavage site, and may be based on a repeat from a CRISPR locus. The methods may be practiced in vivo or in vitro. Also provided are polypeptides that have Cas6 endoribonuclease activity in the presence of a target RNA polynucleotide, and methods for using the polypeptides. | 09-08-2011 |
20110189776 | PROKARYOTIC RNAi-LIKE SYSTEM AND METHODS OF USE - Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5′ region and a 3′ region. The 5′ region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3′ region is substantially complementary to a portion of the target polynucleotide. The methods may be practiced in a prokaryotic microbe or in vitro. Also provided are polypeptides that have endonuclease activity in the presence of a psiRNA and a target polynucleotide, and methods for using the polypeptides. | 08-04-2011 |
20110111473 | YEAST CELLS AND METHODS FOR INCREASING ETHANOL PRODUCTION - Provided herein are methods for producing ethanol using yeast to ferment pretreated solid lignocellulosic materials such as pretreated solid lignocellulosic materials obtained from softwoods like pine. The pretreated solid lignocellulosic material is present at a concentration of at least 12% solids, and at least 30 grams ethanol per liter, preferably at least 40 grams ethanol per liter, are produced within 48 hours. In some aspects, the pretreated solid lignocellulosic material is not detoxified prior to the fermentation. Also provided herein are yeast that ferment a composition that includes pretreated solid lignocellulosic material at a concentration of at least 12% solids to yield at least 30 grams ethanol per liter, preferably at least 40 grams ethanol per liter, in 48 hours. Further provided herein are methods for acclimatizing yeast. | 05-12-2011 |
20110033875 | GLYCOPROTEIN CANCER BIOMARKER - The invention relates to glycoproteins having a cancer-specific glycoform. Cancer-specific glycoforms are useful in diagnostics and therapeutics. | 02-10-2011 |
20110020875 | HYDROGENASE POLYPEPTIDE AND METHODS OF USE - Provided herein are polypeptides having hydrogenase activity. The polypeptide may be multimeric, and may have hydrogenase activity of at least 0.05 micromoles H | 01-27-2011 |
20100323909 | DIAGNOSTIC ASSAY FOR TRYPANOSOMA CRUZI INFECTION - A sensitive, multicomponent diagnostic test for infection with | 12-23-2010 |
20100304450 | MICROBIAL PRODUCTION OF PYRUVATE AND PYRUVATE DERIVATIVES - Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a carbon sources. | 12-02-2010 |
20100298252 | METHODS AND COMPOSITIONS FOR OPHTHALMIC TREATMENT OF FUNGAL AND BACTERIAL INFECTIONS - The present invention provides methods and compositions for use in the methods for contacting an eye of a patient with an effective amount of therapeutic composition comprising a pharmaceutically acceptable chelating agent, a pharmaceutically acceptable pH buffering agent, and an antimicrobial agent. | 11-25-2010 |
20100297609 | VIVO ISOTOPIC LABELING METHOD FOR QUANTITATIVE GLYCOMICS - The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells. | 11-25-2010 |
20100297250 | ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS - 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate. | 11-25-2010 |
20100297173 | PROPHYLACTIC AND THERAPEUTIC IMMUNIZATION AGAINST PROTOZOAN INFECTION AND DISEASE - Polypeptide and polynucleotide vaccines effective to treat or prevent infection of a mammal, such as a dog, a cat, or a human, by a protozoan. Methods of treatment and prevention are also provided, including therapeutic administration of the vaccine to an infected mammal to prevent progression of infection to a chronic debilitating disease state. Preferred embodiments of the polynucleotide vaccine contain nucleotide coding regions that encode polypeptides that are surface-associated or secreted by | 11-25-2010 |
20100279287 | COMPOSITIONS AND METHODS USEFUL FOR SITE-DIRECTED RECOMBINATION IN PLANTS - This invention relates generally to useful compositions and methods related to plant site-directed recombination. In particular, the invention relates to novel nucleic acid sequences unique to a portion of the sorghum NBS-LRR region, as well as vectors, seeds, plant parts and plants comprising these sequences. Methods to investigate recombination co-factors, and methods to investigate potential herbicides are within the scope. This invention also relates to fungal pathogens of sorghum, particularly | 11-04-2010 |
20100278864 | Rabies Vaccine - An attenuated rabies virus for use as a live vaccine. The attenuated rabies virus expresses an immune factor that enhances immune response upon administration of the live vaccine. | 11-04-2010 |
20100266674 | L-ODDC PRODRUGS FOR CANCER - The main drawback in the use of most nucleoside anticancer agents originates from their hydrophilic nature, of which property requires a high and frequent dosage for an intravenous administration. Unlike other nucleoside anti-tumor agents, troxacitabine appears to predominantly enter tumor cells by passive diffusion rather then by using nucleoside transporters, although this may be model dependent. Accordingly, in the present work, a small library of twenty troxacitabine prodrugs has been synthesized using a parallel approach in order to evaluate the relationship between the lipophilicity of the prodrugs and their antitumor activity. Biological evaluation of the prodrugs on two non-small cell lung cancer cell lines (A549 and SW1573) and in pancreatic cell lines clearly showed better antitumor activity than that of troxacitabine, with IC | 10-21-2010 |
20100218290 | SOUTHERN HIGHBUSH BLUEBERRY PLANT NAMED 'TH-682' - The new variety ‘TH-682’ is provided. The new and distinct variety ripens early compared to rabbiteye varieties generally available to homeowners and produces an abundance of attractive, light blue fruit that are generally large and have good flavor. The plant of the new variety ‘TH-682’ is vigorous, produces an attractive fall foliage color and is estimated to have a chilling requirement of approximately 500 to 550 hours below approximately 45° F. The asexually reproduced variety is reliably propagated vegetatively. | 08-26-2010 |
20100212054 | Pennisetum 'Tift-23' - The new variety | 08-19-2010 |
20100212053 | PENNISETUM PLANT NAMED 'TIFT-17' - The new variety | 08-19-2010 |
20100196881 | REVERSE RESTRICTION FRAGMENT LENGTH POLYMORPHISM ASSAY AND USES THEREOF - The present invention presents a Reverse Restriction Fragment Length Polymorphism (RRFLP) method for the detection of the presence of an informative restriction enzyme site in a nucleotide sequence. The method includes digesting a sample with the informative restriction enzyme; performing polymerase chain reaction (PCR) on the digested sample with an oligonucleotide primer pair that flanks the informative restriction enzyme site; determining the Ct value of the sample; comparing the Ct value of the sample to the Ct value from a control sample; and calculating a ΔCt value, wherein a ΔCt value is the Ct value of the sample minus the Ct value of a control; and wherein a ΔCt value ≧+1 indicates that the informative restriction enzyme sites is present in the nucleotide sequence. The present invention includes the application of the RRFLP method for detection of the infectious laryngotracheitis virus (ILTV). | 08-05-2010 |
20100160207 | Feedback Prodrug - Compounds and methods for use in selectively inhibiting a lytic enzyme based on feedback inhibition. The conjugated compound serves as a substrate for a lytic enzyme. Cleavage of the conjugated compound by the lytic enzyme releases an inhibitor of the enzyme. | 06-24-2010 |
20100144664 | CARBOCYCLIC COMPOUNDS AND METHODS FOR TREATING EMERGING DISEASE, INCLUDING INFLUENZA AND VENEZUELA EQUINE ENCEPHALITIS VIRUS - The present invention relates to the use of carbodine and 5-F carbodine and analogs thereof for use in the treatment or prophylaxis of influenza, in particular the H5N1 strain of Avian Influenza A virus or “bird flu” strain of influenza as well as the treatment or prophylaxis of Venezuela equine encephalitis virus or VEE. | 06-10-2010 |
20100122369 | Switchgrass Cultivar EG1102 - A switchgrass cultivar designated EG1102 is disclosed. The invention relates to the seeds of switchgrass cultivar EG1102, to the plants of switchgrass EG1102, to plant parts of switchgrass cultivar EG1102 and to methods for producing a switchgrass plant produced by crossing switchgrass cultivar EG1102 with itself or with another switchgrass variety. The invention also relates to methods for producing a switchgrass plant containing in its genetic material one or more transgenes and to the transgenic switchgrass plants and plant parts produced by those methods. This invention also relates to switchgrass cultivars or breeding cultivars and plant parts derived from switchgrass variety EG1102, to methods for producing other switchgrass cultivars, lines or plant parts derived from switchgrass cultivar EG1102 and to the switchgrass plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid switchgrass seeds, plants and plant parts produced by crossing the cultivar EG1102 with another switchgrass cultivar. | 05-13-2010 |
20100122368 | Switchgrass Cultivar EG1101 - A switchgrass cultivar designated EG1101 is disclosed. Also disclosed are seeds of switchgrass cultivar EG1101, plants of switchgrass EG1101, plant parts of switchgrass cultivar EG1101 and methods for producing a switchgrass plant produced by crossing switchgrass cultivar EG1101 with itself or with another switchgrass variety. Methods are also described for producing a switchgrass plant containing in its genetic material one or more transgenes and to the transgenic switchgrass plants and plant parts produced by those methods. Switchgrass cultivars or breeding cultivars and plant parts derived from switchgrass variety EG1101, methods for producing other switchgrass cultivars, lines or plant parts derived from switchgrass cultivar EG1101 and the switchgrass plants, varieties, and their parts derived from use of those methods are described herein. Hybrid switchgrass seeds, plants and plant parts produced by crossing the cultivar EG1101 with another switchgrass cultivar are also described. | 05-13-2010 |
20100068753 | Biotin-facilitated transport in gram negative bacteria - Biotinylation of compounds such as peptides and peptidomimetics facilitates illicit transport of the compounds into Gram negative bacteria. | 03-18-2010 |
20100055131 | REOVIRUS COMPOSITIONS AND METHODS OF USE - The present invention relates to novel strains of avian reovirus that were isolated from severe cases of Runting Stunting Syndrome in young broiler chickens in southeast United States. The invention is directed to avian reoviruses that impair digestion in poultry, diagnostic assays using nucleotide- or amino acid-specific components of such viruses, and to vaccines that protect chickens from disease caused by such viruses. Nucleotide sequences for the SI gene, encoding the sigma C minor outer capsid protein, were amplified, and the nucleotide and predicted amino acid sequences were compared with sequences from other recently isolated reovirus field isolates and vaccine strains. Antigenic and molecular characterization of the newly isolated reoviruses revealed a lack of homogeneity with current U.S. isolates, with less than 60% percent amino acid similarity across the sigma C protein. Sequence comparisons with previously reported malabsorption isolates from Europe and Asia revealed a higher amino acid similarity, approaching 80%. | 03-04-2010 |
20100041895 | Synthesis and Stabilization of Neutral Compounds with Homonuclear Bonds - The present invention is directed to the synthesis and stabilization of neutral molecules containing homonuclear single or multiple bonds, methods of preparation, and uses thereof. | 02-18-2010 |
20090324550 | COMPOSITION AND METHOD FOR INHIBITION OF MICROORGANISMS - A composition and method for the inhibition of microorganisms. | 12-31-2009 |
20090313733 | INDIAN HAWTHORN PLANT NAMED 'RUTRHAPH1' - A new and distinct cultivar of hawthorn, | 12-17-2009 |
20090311747 | VECTORS AND METHODS FOR HIGH THROUGHPUT CO-EXPRESSIONS - The present invention includes vectors and methods for high throughput co-expression. | 12-17-2009 |
20090212055 | Litter Receptacle - A litter receptacle system, including: a support frame; a container for receiving and storing litter; a coupler; and a retention device; wherein the coupler rotatably couples the container to the support frame; the retention device is in communication with the support frame and the container; and the retention device is operable to releasably secure the container to the support frame, and a method of using the same. | 08-27-2009 |
20090208533 | NEISSERIA MENINGITIDIS SEROGROUP A CAPSULAR POLYSACCHARIDE ACETYLTRANSFERASE, METHODS AND COMPOSITIONS - Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup A | 08-20-2009 |
20090151033 | HYDRANGEA MACROPHYLLA PLANT NAMED 'PIIHM-I' - A new and distinct cultivar of | 06-11-2009 |
20090060266 | Methods and Systems for Analyzing Ratiometric Data - Systems and methods for analyzing ratiometric data, e.g., ratiometric image data such as fluorescent image data. | 03-05-2009 |
20090053145 | ANTI-VIRAL COMPOSITIONS AND METHODS OF USE IN CATTLE - Aspects of the present disclosure relate to therapeutic RNAi compositions and methods of use thereof for treating and/or preventing disease, disorder, and/or conditions—associated with bovine respiratory syncytial virus (BRSV) infections in cattle. | 02-26-2009 |
20090042247 | N-ACETYLGLUCOSAMINYLTRANSFERASE VB CODING SEQUENCES, RECOMBINANT CELLS AND METHODS - A previously unknown mammalian UDP-N-acetylglucosamine:α-6-D-mannoside β-1,6-N-acetylglucosaminyl-transferase (termed GlcNAc T-Vb herein) coding sequence, protein, recombinant host cells and antibodies which specifically bind GlcNAc T-Vb are described. In particular, GlcNAc T-Vb of mouse is disclosed. | 02-12-2009 |
20090041836 | Glycolipopeptide and uses thereof - A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof. | 02-12-2009 |
20090018075 | Peptides in Inhibiting Insects - The subject invention pertains to the use of peptide fragments of cadherins (including cadherin-like proteins). The subject invention includes a cell (and use thereof) comprising a polynucleotide that expresses the peptide fragment. The subject invention includes methods of feeding the peptides to insects. In preferred embodiments, the peptides are fed to target insects together with one or more insecticidal proteins, preferably (but not limited to) B.t. Cry proteins. When used in this manner, the peptide fragment can not only enhance the apparent toxin activity of the Cry protein against the insect species that was the source of the receptor but also against other insect species. Preferably, the cadherin is a | 01-15-2009 |
20090018074 | Peptides for Inhibiting Insects - The subject invention pertains to the use of peptide fragments of cadherins (including cadherin-like proteins). The subject invention includes a cell (and use thereof) comprising a polynucleotide that expresses the peptide fragment. The subject invention includes methods of feeding the peptides to insects. In preferred embodiments, the peptides are fed to target insects together with one or more insecticidal proteins, preferably (but not limited to) B.t. Cry proteins. When used in this manner, the peptide fragment can not only enhance the apparent toxin activity of the Cry protein against the insect species that was the source of the receptor but also against other insect species. Preferably, the cadherin is a | 01-15-2009 |
20090004696 | Stabilized bioactive peptides and methods of identification, synthesis, and use - An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues. | 01-01-2009 |
20080300985 | System and Method for Providing Media Content to Physically Proximate Mobile Devices - In one embodiment, a system and a method pertain to displaying an advertisement, determining media content related to the advertisement to send to a physically proximate mobile device, wirelessly connecting to the physically proximate mobile device, wirelessly transmitting the determined media content to the physically proximate mobile device using a short-range wireless communication protocol. | 12-04-2008 |
20080299895 | Systems and Methods for Providing Information to Exhibition Visitors - In one embodiment, a system and a method for providing information to exhibition visitors pertain to a visitor of an exhibition transmitting with a mobile device a code associated with the exhibition, a server computer receiving the code from the mobile device and identifying a link to downloadable content associated with the code, the server computer sending the link to the mobile device, the visitor selecting the link on the mobile device, and the mobile device downloading content relevant to the exhibition and displaying it to the user. | 12-04-2008 |
20080281919 | System and Method for Sharing Images - In one embodiment, a system and a method for sharing images relate to receiving images transmitted via the Internet and intended for viewing by a particular intended recipient, automatically storing the images in association with the intended recipient, detecting physical proximity of the intended recipient to a display device, and responsive to the detecting, displaying the images on the display device for the intended recipient. | 11-13-2008 |
20080268533 | Methods and Compositions Utilizing Myc and Gsk3Beta to Manipulate the Pluripotency of Embryonic Stem Cells - The present invention provides methods for stabilizing pluripotent cells through the transcriptional activation of c-myc. Alternatively, the cells are stabilized through the transcriptional activation of c-myc, and the stabilization of c-myc protein levels. c-myc protein can be stabilized through the inhibition of GSK3β or through other components of the cellular machinery that impact on c-myc stability. The invention contemplates the stabilized pluripotent cells produced using the methods described herein. Methods for the identification of compounds that modulate the stabilization of pluripotent cells through modulating transcriptional activation of c-myc, stabilization of c-myc protein levels, and/or inhibition of GSK3β activity are also contemplated. | 10-30-2008 |