| University of Connecticut Patent applications |
| Patent application number | Title | Published |
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| 20120122767 | LACTOFERRIN-BASED BIOMATERIALS FOR TISSUE REGENERATION AND DRUG DELIVERY - The invention provides biomatrix compositions comprising cross-linked lactoferrin, either alone or in combination with other organic or inorganic components. Also provided are methods of making and using the biomatrix compositions. As described herein, cross-linked lactoferrin biomatrix retains the bioactivities of the lactoferrin molecule. The biomatrix composition can act as a matrix for cell adhesion and growth and is particularly useful in musculoskeletal tissue regeneration. The biomatrix compositions can be pre-formed or injectable and can act as a cell, drug or protein delivery vehicle. | 05-17-2012 |
| 20120095047 | Novel Heteropyrrole Analogs Acting on Cannabinoid Receptors - Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect discloses hetero pyrrole analogs acting as antagonists for the CB1 and/or the CB2 receptors. Another aspect discloses hetero pyrrole analogs having selectivity for the CB1 or CB2 cannabinoid receptor. Also disclosed are pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect. | 04-19-2012 |
| 20120083446 | NOVEL ALBUMIN-FREE FACTOR VIII FORMULATIONS - An albumin-free Factor VIII formulation comprising, 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent. In a further embodiment, the formulation can comprise: 300 mM to 500 mM NaCl; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; and a buffering agent. | 04-05-2012 |
| 20120060767 | Progesterone receptor membrane component 1 (PGRMC1) as an indicator of fertility in animals - Methods of evaluating fertility of an animal based on determination of a PGRMC1 characteristic that correlates with animal fertility. In one embodiment, a sample is obtained from an animal, a PGRMC1 characteristic is determined and compared to a baseline PGRMC1 characteristic, wherein a variation between the determined PGRMC1 characteristic and the baseline characteristic indicates a level of fertility of the animal. A PGRMC1 characteristic can be one or more of PGRMC1 expression, transcription, translation, amino acid sequence, nucleic acid sequence, post-translational modification, cell localization or tissue localization. A sample can be a cell sample, a tissue sample, a blood sample, a lymphocyte sample, an oocyte sample, or a sperm sample. The animal can be male or female. In one embodiment, a variation of PGRMC1 nucleic acid sequence indicates reduced fertility of the animal. | 03-15-2012 |
| 20120015363 | Progesterone receptor membrane component 1(PGRMC1) as an indicator of human fertility - Methods of evaluating fertility of a human based on determination of a PGRMC1 characteristic that correlates with human fertility. In one embodiment, a sample is obtained from a human, a PGRMC1 characteristic is determined and compared to a baseline PGRMC1 characteristic, wherein a variation between the determined PGRMC1 characteristic and the baseline characteristic indicates a level of fertility of the human. A PGRMC1 characteristic can be one or more of PGRMC1 expression, transcription, translation, amino acid sequence, nucleic acid sequence, post-translational modification, cell localization or tissue localization. A sample can be a cell sample, a tissue sample, a blood sample, a lymphocyte sample, an oocyte sample, or a sperm sample. A human can be male or female. In one embodiment, a variation of PGRMC1 nucleic acid sequence indicates reduced fertility of the human. | 01-19-2012 |
| 20110317240 | Flexible Electrochromic Devices, Electrodes Therefor, And Methods of Manufacture - An electrochromic fiber or fabric is disclosed. The fiber or fabric includes a flexible, electrically conductive fiber, wherein the fiber comprises a non-electrically conductive organic polymer coated with an electrically conductive polymer; and; a layer comprising an electrochromic material disposed on and surrounding the flexible, electrically conductive fiber; wherein the electrically conductive polymer is PEDOT-PSS, poly(vinylpyridine), a poly(thiophene), a poly(pyrrole), a poly(aniline), a poly(acetylene), a poly(p-phenylenevinylene), a sulfonated polythieno[3,4-b]thiophene, polystyrenesulfonate, or a combination thereof. In one embodiment, the fiber or fabric is both flexible and elastic. The fibers and fabrics are of particular utility in electrochromic devices, particularly those which form or are a part of garments. | 12-29-2011 |
| 20110315563 | SENSORS FOR ANALYTE DETECTION AND METHODS OF MANUFACTURE THEREOF - Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes. | 12-29-2011 |
| 20110304404 | SIGNAL GENERATORS BASED ON SOLID-LIQUID PHASE SWITCHING - A phase-change oscillator and pulse generator, and related methods, are provided. The phase-change oscillator and pulse generator can include a capacitor, a switching element coupled in parallel connection with the capacitor, and a resistor coupled in series with the switching element and configured to supply a bias voltage to the switching element. The switching element can have a low-resistance state in a liquid-phase and a high-resistance state in a solid phase. In addition, the switching element can have a negative thermal coefficient of resistance. In an aspect, the switching element comprises a wire of a semiconducting material having negative thermal coefficient of resistance, such semiconducting material can be doped n-type or p-type. In an aspect, the liquid-phase is a molten state of the wire and the solid-phase is a solid state of the wire. An oscillatory signal is based at least on transitioning between the molten state and the solid state. | 12-15-2011 |
| 20110217337 | BIOACTIVE AGENT FOR BONE TISSUE ENGINEERING - Inventors have discovered a method for inducing bone formation in a patient in need thereof comprising administering an effective amount of benzoyladenosine-3′,5′-cyclic monophosphate (6-Bnz-cAMP) to the patient. Systems for bone tissue engineering, comprising a polymer-based scaffold, such as a PLAGA scaffold and an effective amount of 6-Bnz-cAMP are also disclosed herein. | 09-08-2011 |
| 20110208190 | Natural Polymer-Based Porous Orthopedic Fixation Screw for Bone Repair and Regeneration - A bone fixation device made of polysaccharide particles or microspheres fused into a solid structure is provided herein. The bone fixation device may be in the form of an orthopedic screw, orthopedic pin, or orthopedic plate. Methods of making the bone fixation devices described herein are provided as are methods of treating patients in need of bone repair or replacement by implanting a bone fixation device described herein in the patient at a site of bone damage, ligament damage, or bone deformity. | 08-25-2011 |
| 20110193277 | Smart Vibration Absorber For Traffic Signal Supports - Disclosed herein is a smart vibration absorber for traffic signal supports. In exemplary embodiments, the vibration absorber utilizes the mass of the signal head as a damped vibration absorber. The system may also include a spring and damper in mechanical communication with the signal head. The spring provides resistance to the compression force of the signal head while the damper provides a damping force removing energy from the system. Also disclosed herein is a controllable damper which may be connected to a computing device for varying the damping of the system. The controllable damper may be a magneto-rheological fluid damper. The smart vibration absorber may be constructed as a retrofit for installation on current traffic signals supports. | 08-11-2011 |
| 20110140295 | Electrospun Apatite/Polymer Nano-Composite Scaffolds - An artificial bone composite structure is provided. This structure includes a fibrous matrix that itself includes a plurality of fibers. Also, the structure includes a plurality of hydroxyapatite (HA) particles. These particles are dispersed within the fibrous matrix. Also, the HA particles have controlled size and aspect ratios and are aligned along long axes of the fibers. In some instances, the fibers include poly-(L-lactic acid) (PLLA). | 06-16-2011 |
| 20110091283 | OXIDATION OF ENVIRONMENTAL CONTAMINANTS WITH MIXED VALENT MANGANESE OXIDES - Methods and compositions for reduction of contaminants using manganese-based octahedral molecular sieves. | 04-21-2011 |
| 20110070597 | Thin-Film Passive Samplers for Detection of Hydrophobic Organic Contaminants and Estrogenicity in Various Environments - A thin-film passive sampler for use in detecting hydrophobic organic contaminants in air or aqueous environments. The sampler features a relatively thin layer of a suitable absorbent matrix coated directly on a solid support unit made of an inert material such as titanium or glass fibers. The passive samplers are simple and cost-effective to manufacture, easy to use, and exhibit rapid equilibration times and high accuracy. | 03-24-2011 |
| 20110043611 | DEPTH AND LATERAL SIZE CONTROL OF THREE-DIMENSIONAL IMAGES IN PROJECTION INTEGRAL IMAGING - A method disclosed herein relates to displaying three-dimensional images. The method comprising, projecting integral images to a display device, and displaying three-dimensional images with the display device. Further disclosed herein is an apparatus for displaying orthoscopic 3-D images. The apparatus comprising, a projector for projecting integral images, and a micro-convex-mirror array for displaying the projected images. | 02-24-2011 |
| 20110042315 | PERVAPORATION COMPOSITE MEMBRANE FOR AQUEOUS SOLUTION SEPARATION AND METHODS FOR USING THE SAME - In one embodiment, a membrane comprises: a nonporous, hydrophobic selective layer configured to be on a feed solution side of the membrane and polyethylene layer configured to be on a permeate side of the membrane, wherein the membrane is configured to selectively separate an organic component from an aqueous solution. In some embodiments, the method for separating an organic component from an aqueous stream can comprise: contacting a nonporous, hydrophobic selective layer of a membrane with the aqueous stream comprising the organic component, creating a vacuum on the side of the membrane comprising the support layer, permeating the organic component through the membrane into an exit chamber, and removing the organic component permeate from the exit chamber. | 02-24-2011 |
| 20110029845 | Apparatus, Systems and Methods Including Nonbinary Low Density Parity Check Coding For Enhanced Multicarrier Underwater Acoustic Communications - Advantageous underwater acoustic (UWA) apparatus, systems and methods are provided according to the present disclosure. The apparatus, systems and methods employ nonbinary low density parity check (LDPC) codes that achieve excellent performance and match well with the underlying modulation. The nonbinary LDPC codes of the proposed apparatus, systems and methods are formed, at least in part, from a generator matrix that has a high density to reduce the peak-to-average-power ratio (PAPR) with minimal overhead. The disclosed apparatus, systems and methods employ nonbinary regular LDPC cycle codes if the constellation is large and nonbinary irregular LDPC codes if the constellation is small or moderate. The nonbinary irregular and regular LDPC codes enable: i) parallel processing in linear-time encoding; ii) parallel processing in sequential belief propagation decoding; and iii) considerable resource reduction on the code storage for encoding and decoding. | 02-03-2011 |
| 20110017715 | Systems and Methods For Enhanced Control of Laser Drilling Processes - Systems and methods are provided for monitoring and/or controlling laser drilling processes based on atomic emission spectral emissions that are collected in real time during laser drilling. The systems and methods may be used to monitor and control laser drilling operations across a range of materials, e.g., metals (including alloys) and ceramics, and may be used to identify spectral characteristics that signify hole completion and to manage/discontinue laser drilling operations based thereon. The ability to precisely monitor for hole completion provides the important advantage of reducing unnecessary laser pulses, which otherwise could reduce manufacturing efficiency and/or increase thermal or mechanical damage to the component material. The systems and methods may also be employed to control laser drilling operations so as to enhance hole quality and/or to implement corrective action when/if necessary to ensure that laser drilling operations yield high quality drilled holes. | 01-27-2011 |
| 20110015159 | METHODS OF INHIBITING VASCULAR PERMEABILITY AND APOPTOSIS - Agonists of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated forms which serve as sphingosine-1-phosphate receptor agonists. The vascular endothelial sphingosine-1-phosphate receptor agonists are employed in methods of treating a mammal for vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels. The sphingosine-1-phosphate receptor agonists can be used for the manufacture of a medicament for treating vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels. | 01-20-2011 |
| 20110013487 | APPARATUS, SYSTEMS AND METHODS FOR ENHANCED DETECTION, SYNCHRONIZATION AND ONLINE DOPPLER SCALE ESTIMATION FOR UNDERWATER ACOUSTIC COMMUNICATIONS - Advantageous online and/or real-time OFDM-based underwater acoustic (UWA) apparatus, systems and methods are provided according to the present disclosure. The apparatus, systems and methods employ a receiver with a bank of parallel branches, with each branch having a self-correlator matched to a different waveform scaling factor. A detection is declared when any of the branches leads to a correlation metric larger than a pre-defined threshold. The branch with the largest metric yields a Doppler scale estimate and a coarse synchronization point. The proposed apparatus, systems and methods use one OFDM preamble, thereby avoiding the need to buffer the whole data packet before data demodulation and enabling online and/or real-time operation. Thus, the disclosed apparatus, systems and methods are advantageously applicable to UWA communications. | 01-20-2011 |
| 20100293627 | METHOD FOR CLONING ANIMALS WITH TARGETTED GENETIC ALTERATIONS BY TRANSFER OF LONG-TERM CULTURED MALE OR FEMALE SOMATIC CELL NUCLEI, COMPRISING ARTIFICIALLY-INDUCED GENETIC ALTERATIONS, TO ENUCLEATED RECIPIENT CELLS - An improved method of nuclear transfer employing long-term cultured somatic cells as the donor cells and enucleated oocytes as the recipient cells to produce dividing cybrids. Such cybrids are useful for developing viable animals clones when nurtured in a suitable host environment. | 11-18-2010 |
| 20100288343 | Nucleic acid-based photovoltaic cell - Photovoltaic cells containing nucleic acid materials and methods of production and use are provided. The nucleic acid materials have photovoltaic donor and acceptor molecules incorporated therein and define a spatial organization and orientation for these molecules that inhibits recombination of excitons and promotes efficiency in the photovoltaic cell. Preferred nucleic acid materials contain nucleic acid molecules complexed with ionic surfactants and are in the form of films, fibers, nanofibers, or non-woven meshes. | 11-18-2010 |
| 20100260713 | Compositions and Methods for the Inhibition of Hepatitis C Viral Replication with Structural Analogs - Compositions and methods for the inhibition of viral replication are provided. In some embodiments, the compositions include a nucleic acid sequence that is identical to a region of the hepatitis C virus (HCV) genome. In other embodiments, the compositions may include a nucleic acid sequence that has at least about 45% to about 95% sequence identity to the native HCV sequence and that has a similar secondary and tertiary structure to the native HCV sequence. In other embodiments, the compositions may include a nucleic acid sequence that does not have significant sequence identity to the native HCV sequence and that has a similar secondary and tertiary structure to the native HCV sequence. Also provided are methods for the treatment of a patient having an HCV infection by administering one of the compositions described herein, and uses of the compositions described herein in the manufacture of a medicament for the inhibition of HCV replication. | 10-14-2010 |
| 20100249931 | MECHANICALLY COMPETENT NATURAL POLYMER BASED POROUS GRAFTS FOR BONE REPAIR AND REGENERATION - The invention provides a scaffold for bone or cartilage replacement, in which the scaffold is fabricated from naturally derived polymers. In one embodiment the invention provides a bone replacement scaffold, wherein the scaffold comprises sintered polysaccharide microspheres. In a particular embodiment the invention provides a bone replacement scaffold, in which the scaffold comprises polysaccharide microspheres comprising ethyl cellulose microspheres and/or cellulose acetate microspheres. The invention further includes methods of making bone replacement scaffolds and methods of treating bone injury in an animal. | 09-30-2010 |
| 20100245971 | FLEXIBLE ELECTROCHROMIC DEVICES, ELECTRODES THEREFOR, AND METHODS OF MANUFACTURE - An electrochromic fiber or fabric is disclosed. The fiber or fabric includes a flexible, electrically conductive fiber, and a layer comprising an electrochromic material disposed on and surrounding the flexible, electrically conductive fiber. In one embodiment, the fiber or fabric is both flexible and elastic. The fibers and fabrics are of particular utility in electrochromic devices, particularly those which form or are a part of garments. | 09-30-2010 |
| 20100226957 | Protein-Based Artificial Retinas - Multilayer protein films are provided, which comprise native bacteriorhodopsin and/or specialized bacteriorhodopsin mutants as the photoactive element. Also provided are artificial subretinal and epiretinal implants carrying such bacteriorhodopsin films, as well as methods for making and using the same, for example, to treat retinal diseases and conditions. | 09-09-2010 |
| 20100221838 | DIALYSIS ADAPTER CELL AND METHOD OF USE - A dialysis adapter cell includes a housing comprising a plurality of pillars extending between and attached to a top plate and a bottom plate to form a hollow receptacle, wherein the top plate comprises an aperture configured to provide access to the hollow receptacle; a dialysis membrane disposed about the housing and sealingly engaged to the top plate and the bottom plate; and a platform in physical communication with the bottom plate and configured to position the dialysis adapter cell in a sample holder of a United States Pharmacopoeia dissolution apparatus 4 flow-through cell. | 09-02-2010 |
| 20100180950 | LOW-TEMPERATURE SURFACE DOPING/ALLOYING/COATING OF LARGE SCALE SEMICONDUCTOR NANOWIRE ARRAYS - A method and corresponding system for providing a uniform nanowire array including uniform nanowires composed of at least three elements is presented. An embodiment of the method includes growing an array of two-element nanowires, and thereafter uniformly doping or alloying each two-element nanowire, with respect to each other two-element nanowire, with at least one doping or alloying element through a wet chemical synthesis with a precursor solution, to produce the uniform array of nanowires composed of at least three elements. The two-element nanowire can include Zn and O, and the at least one doping or alloying element can be Mg, Cd, Mn, Cu, Be, Fe, and Co. Applications of the three-element nanowire array include solar cells and light emitting diodes with improved efficiencies over existing technologies. | 07-22-2010 |
| 20100168018 | FACTOR VIII FORMULATIONS - A Factor VIII (FVIII) composition formulated such that NaCl is not present in the final formulation or is present in trace amounts, which allows for a concomitant reduction in the lyophilization cycle time and increased stability of the lyophilized FVIII. | 07-01-2010 |
| 20100149983 | BROADCAST LATENCY OPTIMIZATION IN MULTIHOP WIRELESS NETWORKS - A system and methodology that can optimize practical performance by reducing broadcast latency and collisions in a multihop wireless network is provided. The system includes an optimization component that determines a schedule for transmitting and/or receiving messages at nodes in the network during one-to-all broadcasting, all-to-all broadcasting, and/or all-to-one collection. The schedule enables each node in wireless network to participate in broadcasting as soon as possible, such that, when a node transmits a message to its parent to deliver the message to a source node, the children of the node also receive the message and initiate broadcasting the message in their subtrees in parallel. Further, during data collection, the schedule for messages to be transmitted to a sink node is determined based in part on a priority associated with the message. Additionally, the generated schedule does not affect a set of theoretical bounds associated with a broadcast algorithm employed by the network. | 06-17-2010 |
| 20100116691 | BIOSENSOR FOR CONTINUOUS MONITORING OF METABOLITES AND PROTEINS AND METHODS OF MANUFACTURE THEREOF - A biosensor comprises a substrate; a reference electrode; a working electrode; a counter electrode; and a plurality of permeability adjusting spacers. The reference electrode, the working electrode and the plurality of permeability adjusting spacers are all being disposed to be substantially parallel to each other to create a plurality of enzyme containing porous sections. The enzyme containing porous sections contain an enzyme; where the enzyme is operative to react with a metabolite to determine the concentration of the metabolite. By combining a number of the aforementioned biosensors, the differential concentration of a target enzyme or protein is determined by monitoring the changes on its metabolite substrates. | 05-13-2010 |
| 20100112380 | Electricity Generation in Single-Chamber Granular Activated Carbon Microbial Fuel Cells Treating Wastewater - An apparatus and method for producing electrical power and treating wastewater is provided. The apparatus and method oxidize bacteria and substrates naturally occurring in wastewater in a chamber, generating electrons which run from an anode to a cathode through an associated circuit. As a result of the oxidation reactions, the apparatus and method remove impurities from the wastewater and generate electrical power. | 05-06-2010 |
| 20100092124 | Resonant Leaky-Mode Photonic Elements and Methods for Spectral and Polarization Control - Optical devices with versatile spectral attributes are provided that are implemented with one or more modulated and homogeneous layers to realize leaky-mode resonance operation and corresponding versatile spectral-band design. The first and/or higher multiple evanescent diffraction orders are applied to excite one or more leaky modes. The one- or two-dimensional periodic structure, fashioned by proper distribution of materials within each period, can have a resulting symmetric or asymmetric profile to permit a broadened variety of resonant leaky-mode devices to be realized. Thus, the attributes of the optical device permit, among other things, adjacent, distinct resonance frequencies or wavelengths to be produced, convenient shaping of the reflection and transmission spectra for such optical device to be accomplished, and the wavelength resonance locations to be precisely controlled so as to affect the extent to which the leaky modes interact with each other. Further, the profile asymmetry allows for the precise spectral spacing of interactive leaky modes so as to provide greater flexibility in optical device design. | 04-15-2010 |
| 20100075904 | Carbon nanotube composite scaffolds for bone tissue engineering - The present invention provides biocompatible composite materials that can be fabricated into a scaffold having properties suitable for bone repair and regeneration. These scaffolds have sufficient mechanical strength to be useful for the repair and regeneration of cortical bone. | 03-25-2010 |
| 20100044230 | METHODS FOR SEPARATING CARBON NANOTUBES - Disclosed herein too is a method that includes dispersing nanotubes in media that comprises flavin moieties substituted with solubilizing side chains, and/or non-flavin containing molecular species; self-assembling the flavin moieties and other non-flavin containing molecular species in a pattern that is orderly wrapped around the nanotubes to form a composite; introducing desired amounts of an optional reagent that competes with self-assembly in order to disturb the wrapping around nanotubes with moderate order; and centrifuging the mass of the nanotubes and the composites to extract the composite from other nanotubes that are not in composite form. | 02-25-2010 |
| 20100025660 | SEMICONDUCTOR DEVICES, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME - Disclosed herein is a device comprising a source region, a drain region and a gate layer; the source region, the drain region and the gate layer being disposed on a semiconductor host; the gate layer being disposed between source and drain regions; the gate layer comprising a first gate-insulator layer; a gate layer comprising carbon nanotubes and/or graphene. Disclosed herein too is a method comprising disposing a source region, a drain region and a gate layer on a semiconductor host; the gate layer being disposed between the source region and the drain region; the gate layer comprising carbon nanotubes and/or graphene. | 02-04-2010 |
| 20090312175 | Increased Activity of Catalyst Using Inorganic Acids - The present disclosure provides for improved electrochemical devices (e.g., fuel cells, metal air batteries, ultra capacitors, etc.) and components therefore. More particularly, the present disclosure provides for improved systems and methods for producing materials, membranes, electrode assemblies (e.g., membrane electrode assemblies) and electrochemical devices employing the membranes and/or electrode assemblies. The present disclosure provides for improved systems and methods for producing high activity materials, membranes and/or electrode assemblies (e.g., MEAs) for use in electrochemical devices, wherein the high activity membranes and/or electrode assemblies include at least one inorganic acid. In exemplary embodiments, the present disclosure provides for improved systems and methods for producing high activity membranes and/or electrode assemblies (e.g., MEAs) for use in electrochemical devices, wherein the high activity membranes and/or electrode assemblies include at least one inorganic acid in the catalyst layer and/or in the cathode. | 12-17-2009 |
| 20090288222 | Transgenic plants overexpressing a plant vacuolar Pyrophosphatase - Transgenic plants are described which are engineered to overexpress vacuolar H | 11-19-2009 |
| 20090268511 | Bacteriorhodopsin Protein Variants and Methods of Use for Long Term Data Storage - Bacteriorhodopsin protein variants and methods using the bacteriorhodopsin variants for performance in holographic and three-dimensional (3D) memory storage devices are described. The amino acid and chemical modifications of bacteriorhodopsin provided herein achieve greatly enhanced protein performance. The memory storage devices write, read and erase data proficiently. The bacteriorhodopsin protein variants are useful in optical memory storage and associative processor systems. Irradiation of the light-sensitive protein with light of known wavelength causes the protein to switch between different states. The variants enter the branched photocycle via a single or a two photon process and form the permanent ‘Q’ state more efficiently than the wild-type bacteriorhodopsin protein. This branching photocycle of the variants is exploited in the fabrication of 3D memory storage devices. | 10-29-2009 |
| 20090238751 | Process Intensification In Microreactors - The present disclosure provides for a chemical reactor which includes elongate chambers defining an arrangement and including first, second, and third elongate chambers adapted to support respective distinct first, second, and third reactor functions associated with respective first, second, and third process feeds, and a distributor arranged in fluidic communication with each of the elongate chambers and for connecting the elongate chambers to at least one fluid source. The distributor is dimensioned to produce a two-dimensional radial distribution of fluidic flow through the first, second, and third elongate chambers with respect to the first, second, and third process feeds. The chemical reactor may further include a monolith catalyst support including an N×M array of channels including the elongated chambers. The elongate chambers and the distributor may manifest an interchangeable cartridge-based system wherein the arrangement of the elongate chambers is selectably detachable from the distributor and replaceable. | 09-24-2009 |
| 20090230698 | Method And Apparatus For Generating Electricity While A User Is Moving - The present disclosure provides for systems and methods for generating electricity while a user is moving. More particularly, the present disclosure provides for improved systems and methods for generating electricity while a user is walking or running. In exemplary embodiments, the present disclosure provides for improved systems and methods for generating electricity while a user is moving, wherein the systems and methods for generating electricity while a user is moving are portable, and wherein the systems and methods provide for a high output of auxiliary power to electronic devices and/or loads. | 09-17-2009 |
| 20090142849 | Stable Oxygen Isotope Labeling of Pre-existing Phosphoryl Groups on Phosphomolecules for Modification-Specific Mass Spectrometry - The present invention relates to the production and use of phosphate-specific marker ions labeled with one or more stable oxygen isotopes for analysis of phosphopeptides and other phosphorylated biological and synthetic molecules. | 06-04-2009 |
| 20090129204 | Apparatus, Systems and Methods For Enhanced Multi-Carrier Based Underwater Acoustic Communications - Advantageous OFDM-based underwater acoustic (UWA) apparatus, systems and methods are provided according to the present disclosure. In general, OFDM transmissions over UWA channels encounter frequency-dependent Doppler drifts that destroy the orthogonality among OFDM subcarriers. The disclosed apparatus, systems, and methods use a two-step approach to mitigate frequency-dependent Doppler drifts for zero-padded OFDM transmissions over fast-varying channels: (1) non-uniform Doppler compensation via resampling to convert a “wideband” problem into a “narrowband” problem; and (2) high-resolution uniform compensation on the residual Doppler. The disclosed apparatus, systems and methods are based on block-by-block processing and do not rely on channel dependence across OFDM blocks. Thus, the disclosed apparatus, systems and methods are advantageously applicable for fast-varying UWA channels. | 05-21-2009 |
| 20090117519 | STRUCTURAL/BIOLOGICAL IMPLANT SYSTEM - A structural/biological implant and method of use. The implant being utilized as a single or multiple staged system that is designed to encourage new alveolar bone growth with or without the need to obtain autologous bone. The implant has an apical portion that is fastened into existing bone, with the remainder of the implant left outside of existing bone. The exposed portion of the implant may have an external shape or configuration with a variety of attached and/or integrally formed mechanical retention and stability elements. Osteotropic/angiotropic material may be associated with the implant to induce and or conduct new bone growth and possible vascularization, thus, rather than fitting the implant into the bone, the bone is grown integratively with the implant. The osteotropic/angiotropic materials may be simultaneously placed with the staged implant to provide consistent stabilization for the materials and to provide an immediately available surface for bone cell adhesion and growth. The invention thus allows implants to be used in location where the volume and/or shape of the bone would not be adequate for existing implant systems. | 05-07-2009 |
| 20090105287 | Inhibitors of Dihydrofolate Reductase With Antibacterial Antiprotozoal, Antifungal and Anticancer Properties - The compositions and methods described herein discloses the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These DHFR inhibitors are potent and selective for many different pathogenic organisms, including the DHFR enzyme from bacteria such as | 04-23-2009 |
| 20090101498 | GLUCOSE SENSORS AND METHODS OF MANUFACTURE THEREOF - Disclosed herein is a device that functions as a glucose sensor. The device has a reference electrode; a counter electrode, a working electrode; an electrically conducting membrane; an enzyme layer; a semi-permeable membrane; a first layer of a first hydrogel in operative communication with the working electrode; the first layer of the first hydrogel being operative to store oxygen; wherein the amount of stored oxygen is proportional to the number of freeze-thaw cycles that the hydrogel is subjected to; and a second layer of the second hydrogel. Disclosed too is a method that comprises using periodically biased amperometry towards interrogation of implantable glucose sensors to improve both sensor's sensitivity and linearity while at the same time enable internal calibration against sensor drifts that originate from changes in either electrode activity or membrane permeability as a result of fouling, calcification and/or fibrosis. | 04-23-2009 |
| 20080299153 | B. ANTHRACIS PREVENTION AND TREATMENT: MUTANT B. ANTHRACIS LACKING LUXS ACTIVITY AND FURANONE INHIBITION OF GROWTH, AI-2 QUORUM SENSING, AND TOXIN PRODUCTION - The present invention pertains to the discovery that | 12-04-2008 |
| 20080213899 | Rotationally Oscillating Injector - A microinjection device is provided that includes an injection element defining a longitudinal axis, and that further includes a motor. The injection element is rotatable about the longitudinal axis by the rotational motor. The injection element is for penetrating a target, such as a cell. A microinjection system is provided that includes the microinjection device and a control unit. The control unit is for controlling a rotational amplitude and a frequency of oscillation of the injection element. A method for penetrating a target to facilitate injecting material therein is provided that includes providing the material to an injection element, contacting the target with a distal end of the injection element, rotating the injection element about a longitudinal axis to form a hole in the target, and penetrating the target with the injection element via the hole formed in the target. A method for performing intra-cytoplasmic sperm injection is provided that includes providing a solution comprising sperm to an injection element, contacting an oocyte with a distal end of the injection element, rotating the injection element alternately clockwise and counterclockwise about a longitudinal axis to form a hole in the oocyte, penetrating the oocyte with the distal end of the injection element via the hole formed in the oocyte, and expelling the solution comprising sperm into the penetrated oocyte. | 09-04-2008 |
