UNIVERSITY OF CINCINNATI Patent applications |
Patent application number | Title | Published |
20160041105 | Optical Sensor - An optical sensor for monitoring an environmental condition, the optical sensor comprising a perfluorosulfonate ionomer membrane comprising a solution, wherein the solution comprises a transition metal-free dye component, wherein exposure of the optical sensor to a specific environmental condition produces a color shift on the optical sensor. | 02-11-2016 |
20160024551 | MULTI-TIERED, HIGH THROUGH-PUT SCREEN FOR COMPOUNDS EFFECTIVE AGAINST BACTERIAL BIOFILM COMPOUNDS EFFECTIVE FOR INHIBITING AND ERADICATING BACTERIAL BIOFILM - A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each tier includes three specific biological process assays. The tier levels are a primary screen, a confirmation screen, and a dose-response screen, and the biological process assays include as says for total bacterial growth, bacterial metabolic activity, and biofilm formation. | 01-28-2016 |
20150309022 | Synthetic Ligands for the Differentiation of Closely Related Toxins and Pathogens - Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1 and Shiga toxin 2. Assay systems and methods for providing an assay are also provided for herein. | 10-29-2015 |
20150299251 | Skin Care Compositions and Methods Comprising Selective Agonists of Melanocortin 1 Receptor - Short tri- and tetrapeptides according to the following Formula I Ar(CH | 10-22-2015 |
20150290300 | Materials and Methods Useful for Treating Glioblastoma - The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when administered in conjunction with rapamycin. SapC-DOPS/rapamycin combination therapy allows physicians to give lower doses of each drug and achieve better therapeutic efficacy. The compositions also allow for less toxicity and fewer off-target effects. Related methods and materials are also provided herein. | 10-15-2015 |
20150246125 | Methods and Compositions for Suppressing IgE-Mediated Anaphylaxis - Methods for suppressing IgE-mediated anaphylaxis are provided herein, which include administering to a person in need thereof a combination of at least two therapeutic agents selected from the group consisting of an antihistamine, one or more beta-adrenergic agonists, and one or more tyrosine kinase antagonists. Also provided herein are methods of suppressing IgE-mediated anaphylaxis associated with immunotherapeutic desensitization of a subject, and pharmaceutical compositions for suppressing IgE-mediated anaphylaxis. | 09-03-2015 |
20150182591 | METHOD OF TREATING HYPERGLYCEMIC DISORDERS USING APOLIPOPROTEIN AIV - Methods for treating hyperglycemia disorders in a subject in need thereof and pharmaceutical compositions for the treatment of hyperglycemia disorders are disclosed. The methods include administering an effective amount of apolipoprotein A-IV to the subject. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject having hyperglycemic disorders, including insulin resistant disorders, such as prediabetes, metabolic syndrome, polycystic ovary disease, type A syndrome, gestational diabetes, and endocrine conditions associated with hyperglycemia, including Cushing's Disease, glucagon excess (glucagon secreting tumors) and acromegaly. | 07-02-2015 |
20150057515 | SWEAT SIMULATION, COLLECTING AND SENSING SYSTEMS - Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor, or on a continuous basis using a chemical, field effect transducer. | 02-26-2015 |
20150031741 | COMPOSITIONS AND METHODS FOR IMPROVING LACTATION - The present disclosure relates to the use of pharmaceutical agents to manipulate serotonin in animal mammary glands. Use of the serotonin agents results in increased PTHrP levels, resulting in the release of calcium from the bone, which improves lactation. | 01-29-2015 |
20140377757 | COMPOSITIONS AND METHODS FOR SCREENING FOR CREATINE TRANSPORTER DEFICIENCY - Amplification primers, sequencing primers, kits for screening, and screening methods for identifying a SLC6A8 creatine transporter gene mutation are disclosed. The screening method includes treating a sample of DNA with polymerase chain reaction amplification primers for amplifying regions of the DNA having SLC6A8 to produce a first, second, and third amplification product, sequencing the first, second, and third amplification products with sequencing primer pairs to provide a DNA sequence of SLC6A8 in the sample, and comparing the DNA sequence of SLC6A8 with a reference DNA sequence of SLC6A8. | 12-25-2014 |
20140350676 | ELEMENTS FOR VERSATILITY OF A PROSTHETIC ANCHOR - A prosthetic anchor to be attached to a natural or prosthetic structure of a human or animal. The anchor includes a central layer with first and second surface. A plurality of fiber bundles, each with a medial portion, are concentrically embedded within the central layer to substantially define a horseshoe-shaped pattern. A substrate element is configured to be secured to the natural or prosthetic structure and to receive the second surface of the central layer. A securing element operably coupled to the second surface of the central layer is configured to secure the central layer to the substrate element in at least two positions. | 11-27-2014 |
20140308326 | ANTIMICROBIAL COMPOSITIONS OF AMINOGLYCOSIDIC ANTIBIOTICS AND ZINC ION CHELATORS SPECIFICALLY FORMULATED FOR ENHANCED INHIBITION OF BACTERIAL COLONIZATION AND ANTIBACTERIAL EFFICACY - Pharmaceutical compositions comprising an aminoglycosidic antibiotic and at least one zinc-chelating agent in a specified concentration, and methods of inhibiting bacterial colonization, biofilm formation and if treating bacterial infections utilizing the compositions are provided. Topical formulations suitable for wound care, and surface-applicable formulations suitable for medical, industrial and household disinfecting needs are also described. | 10-16-2014 |
20140287020 | SURGICAL DEVICE FOR SKIN THERAPY OR TESTING - A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin. The device contains cultured dermal and epidermal cells on a biocompatible, biodegradable reticulated matrix. All or part of the cells may be autologous, from the recipient of the cultured skin device, which advantageously eliminates concerns of tissue compatibility. The cells may also be modified genetically to provide one or more factors to facilitate healing of the engrafted skin replacement, such as an angiogenic factor to stimulate growth of blood vessels. The inventive device is easy to handle and manipulate for surgical transplant, can be made into large sheets to minimize the number of grafts required to cover a large surface area to be treated, and can be produced within the time frame to treat a burned individual requiring a skin graft. | 09-25-2014 |
20140276867 | PATIENT-SPECIFIC ASSEMBLIES, JIGS, AND METHODS FOR A PERSONALIZED TOTAL HIP ARTHROPLASTY SYSTEM - A patient-specific total hip arthroplasty system including surgical guide and jig instrumentation modeled by computer aided design using image data derived from a specific patient's relevant anatomy. Patient-specific jigs fit surface topography of portions of the acetabulum and femur of the patient and are designed to guide surgical implantation at very precise geometries unique to each patient. Patient-specific pin-locating jigs, pin-rail and spacer systems, acetabular reaming and impacting jigs, and femoral resection and version jigs are fabricated pre-operatively according to the models. Methods for fabricating jig components of the system and methods of performing a total hip arthroplasty utilizing the system are also disclosed. | 09-18-2014 |
20140272942 | Methods of Detecting Influenza Virus - Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method including measuring the enzymatic activity of neuraminidase (NA) in the sample under one or more differentiating conditions selected from the group consisting of pH, binding to anti-NanA antibody, size exclusion, hemagglutinin (HA) binding, chemical inhibition, and combinations thereof. | 09-18-2014 |
20140248289 | Methods and Compositions for the Treatment of Respiratory Conditions Via NKG2D Inhibition - Methods and compositions for the treatment of respiratory conditions are provided. Aspects of the subject methods include administering to the subject a composition comprising an inhibitor of NKG2D-mediated activation of leukocytes. Also provided are compositions suitable for use in the subject methods, as well as pharmaceutical preparations thereof. | 09-04-2014 |
20140243647 | APPARATUSES AND METHODS FOR NEUROLOGICAL STATUS EVALUATION USING ELECTROMAGNETIC SIGNALS - In one embodiment, a neurological status evaluation apparatus includes a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna coupled to the signal generator and configure to transmit the electromagnetic signal, and a receiving antenna positioned proximate to the transmitting antenna such that an evaluation space is defined between the transmitting antenna and the receiving antenna. The biological tissue under evaluation does not contact the transmitting antenna or the receiving antenna. The receiving antenna receives a modulated electromagnetic signal after propagating through the biological tissue under evaluation. The neurological status evaluation apparatus further includes a spectrum analyzer coupled to the receiving antenna, wherein the spectrum analyzer receives and samples the modulated electromagnetic signal. A computing device is coupled to the spectrum analyzer, calculates an evaluation, and provides a neurological status indicator of the biological tissue under evaluation based on the evaluation parameter. | 08-28-2014 |
20140235687 | METHODS OF TREATING COGNITIVE DYSFUNCTION BY MODULATING BRAIN ENERGY METABOLISM - Methods for treating cognitive dysfunction by modulating brain energy metabolism using cyclocreatine or a pharmaceutically acceptable salt thereof are discussed. | 08-21-2014 |
20140220009 | Compositions and Methods for Treating Cocaine-Related Disorders - A method of treating a cocaine-related disorder in an individual is provided, the method including administering to the individual a therapeutic amount of an antibody comprising a human immunoglobulin gamma heavy chain and a murine lambda light chain. In a specific embodiment, the antibody is a monoclonal antibody comprising a murine lambda light chain variable region, a human gamma heavy chain variable region, and a human kappa or lambda light chain constant region. | 08-07-2014 |
20140208852 | MEASURING WALL THICKNESS LOSS FOR A STRUCTURE - Systems, methods and computer storage mediums accurately measure wall thickness in a region of interest included in complex curved structures. Embodiments of the present disclosure relate to generating a wall thickness loss distribution map of a region of interest that provides an accurate representation of wall thickness for the region of interest included in a complex curved structure. The wall thickness loss distribution map is generated from a two-dimensional model of the wall thickness loss distribution of the region of interest. The two-dimensional model is converted from a three-dimensional representation of the wall thickness loss distribution of the region of interest. The three-dimensional representation of the wall thickness is generated by ultrasonic waves generated by a transducer system that propagated through the region of interest. | 07-31-2014 |
20140154277 | Pharmaceutical Compositions Comprising Soluble CD137 - A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of soluble CD137 or CD137 | 06-05-2014 |
20140154244 | Methods of Treating Primary Brain Tumors by Administering Letrozole - The present disclosure relates to the field of cancer treatment, and more specifically to the field of treatment of primary malignant brain tumors. Provided herein are methods of treating primary brain tumors, including gliomas, by administering to a patient in need thereof a therapeutically effective amount of the aromatase inhibitor letrozole. | 06-05-2014 |
20140148402 | Diagnostic Assays and Methods of Treating Pneumonia, Sepsis and Systemic Inflammatory Response Syndrome - Methods for assessing pneumonia in a patient, methods for managing treatment of a patient suspected of having pneumonia, and methods of managing treatment in a patient suffering from pneumonia. The method of assessing pneumonia includes contacting a biological sample with reagents for detection and/or quantification of neutrophil-derived microparticles, determining a level of neutrophil-derived microparticles, and assessing pneumonia if the level is elevated. The method of managing treatment of a patient suspected of having pneumonia includes assessing pneumonia by calculating a concentration of neutrophil-derived microparticles, treating the patient where pneumonia is indicated, and determining treatment response by measuring a post treatment concentration of neutrophil-derived microparticles. The method of managing treatment in a patient suffering from pneumonia includes establishing a baseline concentration of neutrophil-derived microparticles, initiating treatment, and serially monitoring a concentration of neutrophil-derived microparticles during treatment. | 05-29-2014 |
20140030150 | FIBER-OPTIC BIOSENSOR AND BIOSENSING METHODS - A biosensor device that includes a module defining at least one microfluidic channel, an optical waveguide exposed along at least a portion of its length to fluid flow within the microfluidic channel, where a surface of the optical waveguide being prepared to bind a target biomarker, and an excitation source to couple an excitation wavelength of light into the optical waveguide. The device also includes a sensor for detecting emission light from the optical waveguide at an emission wavelength characteristic of binding of the target biomarker. Particular devices include multiple waveguides in multiple microfluidic channels. Particular devices include microfluidic channels with serpentine bump structures that aid molecular transport. | 01-30-2014 |
20140018385 | Identification Of PCNA Targeting Compounds For Cancer Therapy And PCNA Function Regulation - Pharmaceutical compositions and methods for inhibiting cell growth, modulating function of PCNA, treating prostate cancer, and enhancing PCNA trimer formation are disclosed. The methods include administering an effective amount of a compound of Formula (I), Formula (II) | 01-16-2014 |
20140005107 | APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE | 01-02-2014 |
20130344763 | Methods for Electrospinning Hydrophobic Coaxial Fibers into Superhydrophobic and Oleophobic Coaxial Fiber Mats - Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a sheath outlet, ejecting an electrospinnable core solution from the core outlet of the electrospinning coaxial nozzle, ejecting a hydrophobic sheath solution from the sheath outlet of the electrospinning coaxial nozzle, wherein the hydrophobic sheath solution annularly surrounds the core solution, applying a voltage between the electrospinning coaxial nozzle and a collection plate, wherein the voltage induces a jet of the electrospinnable core solution annularly surrounded by the hydrophobic sheath solution to travel from the electrospinning coaxial nozzle to the collection plate to form the hydrophobic coaxial fiber comprising an electrospinnable polymer core coated with a hydrophobic sheath material, and wherein collection of the hydrophobic coaxial fiber on the collection plate yields the superhydrophobic coaxial fiber mat. | 12-26-2013 |
20130239467 | METHOD OF EXTRACTING LIPIDS FROM TRAP GREASE WITH WASTE COOKING OIL - Describe are methods of extracting the lipid fraction from trap grease using vegetable oil, such as vegetable oils sourced from waste cooking oil. The method includes mixing a volume of vegetable oil with a volume of trap grease. The mixture is comprised of an aqueous fraction, a solid fraction, and a lipid fraction. The mixture is heated to a temperature in a range from about 50 degrees C. to about 100 degrees C. for a period of time sufficient to extract at least 80 percent of the lipids from the trap grease. The lipid fraction is then separated from the solid fraction. The method may further include a process of producing biodiesel from the extracted lipid fraction. | 09-19-2013 |
20130230542 | ROS-Activated Compounds as Selective Anti-Cancer Therapeutics - Provided are compounds according to the following Formula I: | 09-05-2013 |
20130215492 | ELECTROWETTING DEVICES ON FLAT AND FLEXIBLE PAPER SUBSTRATES - Electro wetting devices and methods. The electro wetting device | 08-22-2013 |
20130214677 | Nearly Index-Matched Luminescent Glass-Phosphor Composites For Photonic Applications - A light emitting device is described. The light emitting device includes a base; a light emitting diode supported by the base; a first layer spaced apart from the light emitting diode and including a light emitting material, the first layer having a refractive index n | 08-22-2013 |
20130203769 | Targeting Metabolic Adaptive Responses to Chemotherapy - Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC, or upstream or downstream pathway components of S6K1 or mTORC, in association with administration of at least one antagonist of PPARα, PPARδ, or PGC1α. In various embodiments, the compound that inhibits S6K1, mTORC, or upstream or downstream pathway components of S6K1 or mTORC is rapamycin, everolimus, temsirolimus, or imatinib. The antagonist of PPARα, PPARδ, or PGC1α can be GW7647, GW6471, GW501516, GSK3787, or GSK0660. | 08-08-2013 |
20130186399 | ACOUSTIC PRESSURE INDUCERS AND METHODS FOR TREATMENT OF OBSTRUCTIVE SLEEP APNEA - Acoustic pressure inducers and methods for treating obstructive sleep apnea are disclosed. In one embodiment, an acoustic pressure inducer includes an actuator housing having an orifice, a tube having a first end and a second end, and a nasal cannula fluidly coupled to the second end of the tube. The first end of the tube is fluidly coupled to the orifice of the actuator housing such that a gap is present between the first end of the tube and the orifice. The nasal cannula is configured to be positioned proximate to nostrils of a user. The acoustic pressure inducer further includes a vibrating element within the actuator housing and a signal generator. The signal generator component is electrically coupled to the vibrating element and configured to provide an electronic signal to the vibrating element to cause the vibrating element to oscillate within the actuator housing and produce an acoustic jet of air that exits the orifice and enters a nasal passageway of the user through the nasal cannula. | 07-25-2013 |
20130183743 | Microbial Fuel Cell - Transgenic microbes with an altered electrogenic efficacy, biofilms comprising such microbes, and microbial fuel cells comprising such microbes are provided. The microbial fuel cells can be operated as monitors, filtration devices, and sensors. | 07-18-2013 |
20130101610 | Therapeutic Uses of CD137 in Treating Autoimmune Disease - A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of soluble CD137 or CD137 | 04-25-2013 |
20130095503 | SERUM SPLA2-IIA AS DIAGNOSIS MARKER FOR PROSTATE AND LUNG CANCER - Kits for assessing lung cancer in patients with solitary pulmonary nodules and methods for assessing lung cancer. The kit includes reagents for detection and/or quantification of serum secretory phospholipase A | 04-18-2013 |
20130073223 | Turbine-To-Turbine Prognostics Technique For Wind Farms - Methods and systems for predicting an end of life of a wind turbine component including receiving environmental conditions indicative of natural surroundings of wind turbines within a wind turbine farm, receiving component performance metrics indicative of an operation of wind turbines within a wind turbine farm, and distributing the wind turbines into peer-clusters such that the wind turbines within each of the peer-clusters have similar environmental conditions. The methods and systems further include identifying a low performing wind turbine and a remaining portion of wind turbines within one of the peer-clusters based upon a predicted performance model, processing the component performance metrics of the low performing wind turbine, identifying a critical component of the low performing wind turbine and predicting the end of life of the critical component of the low performing wind turbine. | 03-21-2013 |
20130053824 | Handheld Devices For Dilating Tissue - Embodiments of handheld devices for dilating tissue along the paranasal sinuses include a handle assembly that includes a grip portion, an inflation mechanism, and a digital actuation member configured to actuate the inflation mechanism. The handheld devices also include a rigid cannula that includes a distal end and a proximal end, where the rigid cannula is coupled to the handle assembly along the proximal end. The handheld devices further include an inflatable balloon coupled to an outside of the rigid cannula proximate to the distal end, an inflation lumen at least partially disposed along the rigid cannula and in fluid communication with the inflatable balloon and the inflation mechanism, and an aspiration lumen at least partially disposed along the rigid cannula and includes an aspiration port proximate to the distal end. | 02-28-2013 |
20130046021 | METHODS OF TREATING CARDIOMYOPATHY, SYSTOLIC CARDIAC DYSFUNCTION AND THE SYMPTOMS OF CONGESTIVE HEART FAILURE WITH PROBENECID - Described herein are inventions is directed to methods of treating a cardiac dysfunction and symptoms of cardiac dysfunction in a subject that includes administering an amount of probenecid effective to treat a symptom of cardiac dysfunction. The probenecid may be administered in at least one of an injection, orally, or transdermally. The amount of probenecid is sufficient to result in an improved performance on a standardized 6 minute walk test, an improved New York Heart Association (NYHA) classification, a lower diuretic dose requirement, a lower serum BNP levels, a normalization of serum sodium concentrations, and combinations thereof In an embodiment, probenecid is administered over a period of about 8 hours to about 24 hours. Probenecid may be used for short term treatments, i.e., less than a week, or it may be administered in a long term manner, i.e., over a period of weeks, months, or even years. Probenecid may be administered in an amount sufficient to treat the symptoms of cardiac dysfunction. | 02-21-2013 |
20120296512 | METHOD AND SYSTEM FOR ELECTRIC VEHICLE BATTERY PROGNOSTICS AND HEALTH MANAGEMENT - A system for managing mobility of an electrically-powered vehicle. The system includes a monitoring module comprising a plurality of sensors. Each of the plurality of sensors is configured to sense the status of at least one feature of each of the electrically-powered vehicle, an environment in which the electrically-powered vehicle is residing, and a state of health of a battery of the electrically-powered vehicle. A mobility analysis module estimates mobility of the electric-powered vehicle based on the sensed status, and a telematics module displays the sensed statuses, the estimated mobility, or both. The telematics module resides on a cloud-based server. | 11-22-2012 |
20120276552 | SERUM SPLA2-IIA AS DIAGNOSIS MARKER FOR PROSTATE AND LUNG CANCER - Methods for diagnosing prostate cancer and lung cancer are disclosed. The methods include obtaining a biological sample from a subject, determining a level of serum secretory phospholipase A | 11-01-2012 |
20120271167 | Methods of Enhancing Delivery of Drugs Using Ultrasonic Waves and Systems for Performing The Same - Methods and systems for inducing and passively detecting stable cavitation and/or inertial cavitation for targeted drug delivery across a biological membrane are disclosed. Such methods include administering vesicles having a nucleating agent and a therapeutic drug to a vascular system of a patient, and providing an active interval of ultrasonic exposure substantially throughout a targeted treatment zone. The ultrasonic exposure is produced by a source transducer at a specified fundamental frequency, amplitude, duty cycle, and duration. The methods also include detecting a scattered ultrasonic wave, where the scattered ultrasonic wave is received by a detection transducer. Detection of the scattered ultrasonic wave is indicative of stable and/or inertial cavitation. The ultrasonic exposure is provided intermittently in the active intervals separated by rest periods, and substantially less ultrasonic exposure is provided during the rest period than during the active interval. | 10-25-2012 |
20120245211 | Methods of Treating Cognitive Dysfunction by Modulating Brain Energy Metabolism - Methods for treating cognitive dysfunction by modulating brain energy metabolism are discussed. | 09-27-2012 |
20120168309 | ELECTROWETTING AND ELECTROFLUIDIC DEVICES WITH LAPLACE BARRIERS AND RELATED METHODS - Electrowetting and electrofluidic devices and methods. The device includes a hydrophobic channel formed between first and second substrates and a polar fluid and a non-polar fluid contained in the channel. An electrode with a dielectric layer is electrically connected to a voltage source. A Laplace barrier within the hydrophobic channel defines a fluid pathway that is open to the movement of the polar fluid within the channel. The polar fluid moves to a first position when the voltage source is biased at a first voltage that is less than or equal to a threshold voltage. The polar fluid moves to a second position when the voltage source is biased with a second voltage that is greater than the first voltage. | 07-05-2012 |
20120154886 | DISPLAY PIXELS, DISPLAYS, AND METHODS OF OPERATING DISPLAY PIXELS - Electrofluidic and electrowetting display pixels, electrofluidic and electrowetting displays, and methods of operating electrofluidic and electrowetting display pixels. The pixel includes a hydrophobic channel formed between first and second substrates and containing a polar fluid and a non-polar fluid, of which at least one is visible through at least one substrate. An electrode with a dielectric is electrically connected to a voltage source. A Laplace barrier defines a fluid pathway for fluid movement in the channel. The polar fluid moves a first position when the voltage source is biased at a first voltage of less than or equal to a threshold voltage to provide a first display state. The polar fluid moves to a second position when the voltage source is biased with a second voltage, greater than the first voltage, to provide a second display state. | 06-21-2012 |
20120148813 | MULTIFUNCTIONAL NANOCOATINGS AND PROCESS FOR FABRICATING SAME - Embodiments of a coated substrate comprise a substrate ( | 06-14-2012 |
20120135211 | MULTIFUNCTIONAL NANOCOATINGS WITH MIXED NANOPARTICLES AND PROCESS FOR FABRICATING SAME - Embodiments of a coated substrate comprise a substrate ( | 05-31-2012 |
20120130288 | ULTRASOUND-MEDIATED INDUCEMENT, DETECTION, AND ENHANCEMENT OF STABLE CAVITATION - Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes providing a determined level of ultrasonic energy and detecting a scattered level of ultrasonic energy. The system for inducing and passively detecting stable cavitation includes a dual-element annular transducer array configured to provide a fundamental ultrasonic frequency and to detect an ultrasonic frequency that is a derivative of the fundamental frequency. The method of enhancing stable cavitation includes administering a nucleating agent and a thrombolytic agent to a treatment zone, providing a determined level of ultrasonic energy, and detecting a scattered level of ultrasonic energy. | 05-24-2012 |
20120128654 | Allantoin Administration for the Treatment of Neurodegenerative Disease and Neurotrauma - Methods for inhibiting the progression of neurodegenerative diseases and treating neurotrauma-induced damage and cerebrovascular disease are provided herein, the methods including the administration of a safe and effective amount of allantoin to a patient in need thereof. Also provided are pharmaceutical compositions including allantoin for the inhibition of the progression of neurodegenerative diseases and for the treatment of neurotrauma-induced damage and cerebrovascular disease. | 05-24-2012 |
20120093947 | METHOD OF TREATING REACTIVE AIRWAY DISEASE - A method of treating a reactive airway disease in a subject comprising administering at least one peroxidase inhibitor in association with administration of at least one β-agonist. | 04-19-2012 |
20120081777 | ELECTROFLUIDIC IMAGING FILM, DEVICES, AND DISPLAYS, AND METHODS OF MAKING AND USING THE SAME - A device and method of making and using the same. The device includes first and second substrates that are spaced to define a fluid space. Polar and non-polar fluids occupy the fluid space. A first electrode, with a dielectric layer, is positioned on the first substrate and electrically coupled to at least one voltage source, which is configured to supply an electrical bias to the first electrode. The fluid space includes at least one fluid splitting structure that is configured to facilitate the movement of the non-polar fluid into a portion of the polar fluid. Fluid splitting structure assisted movement of the non-polar fluid splits the polar fluid. | 04-05-2012 |
20120010234 | USE OF VEGF-D IN THE DIAGNOSIS OF LYMPHANGIOLEIOMYOMATOSIS (LAM) DISEASE - Described herein are methods of diagnosing lymphangioleiomyomatosis (LAM) that permits differentiating LAM from another lung disorder. Methods of treatment are also provided. | 01-12-2012 |
20110189260 | USE OF ZINC CHELATORS TO INHIBIT BIOFILM FORMATION - A method is provided for inhibiting formation of a biofilm of bacteria, the method including contacting the bacteria with an effective amount of at least one zinc chelator, wherein the bacteria contain at least one zinc adhesion module, whereby formation of the biofilm is inhibited. A method for inhibiting biofilm formation on a device and a topical pharmaceutical composition for the inhibition of biofilm formation are also provided. | 08-04-2011 |
20110136153 | Use of VEGF-D in the Diagnosis of Lymphangioleiomyomatosis (LAM) Disease - Described herein are methods of diagnosing lymphangioleiomyomatosis (LAM) that permits differentiating LAM from another lung disorder. Methods of treatment are also provided. | 06-09-2011 |
20110129461 | Mat II Beta Subunit RNAi and Therapeutic Methods Using Same - The presently disclosed subject matter generally relates to methods and compositions for modulating MAT II activity. More particularly, the presently disclosed subject matter relates to methods and compositions for inhibiting the expression of MAT II β subunit in a subject via RNAi by administering siRNA or shRNA molecules directed to MAT II β subunit. In some embodiments, the methods and compositions of the presently disclosed subject matter generally relates to the treatment of cancer. More particularly, the methods and compositions of the presently disclosed subject matter relates to the inhibition of MAT II β subunit for the treatment of leukemia. | 06-02-2011 |
20110096327 | Spiral Microchannel Particle Separators, Straight Microchannel Particle Separators, and Continuous Particle Separator and Detector Systems - A spiral microchannel particle separator includes an inlet for receiving a solution containing particles, at least two outlets, and a microchannel arranged in a plurality of loops. Particles within a solution flowing through the spiral microchannel experience a lift force F | 04-28-2011 |
20110066391 | METHODS AND SYSTEMS FOR ENERGY PROGNOSIS - In one embodiment, a method for managing an industrial process wherein a processor transforms electronic data into an energy prognosis is provided. An energy related test signal including effective power test data indicative of electrical energy consumed by an energy consuming machine may be received. The energy related test signal may be partitioned into an energy related test sub-signal. Mathematical functions may be applied to the energy related test sub-signal to extract a feature set of data from the energy related test sub-signal. The feature set of data may be transformed with a transformation matrix into a reduced test feature set. The reduced test feature set may be input into a performance assessment algorithm based at least in part upon a reduced training feature set derived from data indicative of electrical energy consumed during healthy operation. A power-based performance index may be generated with the performance assessment algorithm. | 03-17-2011 |
20110003844 | REGULATION OF CARDIAC CONTRACTILITY AND HEART FAILURE PROPENSITY - The methods and compositions of the present invention find use in altering expression of PKCα in transgenic animals. The compositions of the invention include isolated transgenic animal cells, transgenic tissue, transgenic animals, and transgenic mice. The transgenic animals of the invention exhibit altered PKCα activity. The methods allow generation of transgenic animals with altered expression of PKCα. The invention allows modulation of cardiac contractility. In particular, the invention provides a method for altering the susceptibility of a transgenic animal to cardiomyopathy. A transgenic animal of the invention finds use in identifying anti-cardiomyopathic compounds. | 01-06-2011 |
20100324075 | THERAPEUTIC USE OF CARBOXYL ESTER LIPASE INHIBITORS - Compounds, pharmaceutical compositions, and their methods of use in raising serum HDL levels in subjects in need thereof are provided. Also provided are compounds, pharmaceutical compositions, and their methods of use in increasing reverse cholesterol transport in subjects in need thereof. Finally, methods for treating disease by raising serum HDL levels and increasing reverse cholesterol transport are provided. | 12-23-2010 |
20100317536 | CRYSTAL STRUCTURE OF HUMAN GPVI AND APPLICATIONS THEREOF - A crystal comprising the collagen binding domain of human GPVI is provided and defined by structural atomic coordinates. Employing computer modeling based on the crystal structure, including methods for identifying inhibitors of GPVI collagen binding activity, methods for screening libraries of compounds for potential to bind to the GPVI collagen binding domain, and methods of identifying a compound useful for the treatment of a GPVI-mediated disorder, are also provided. | 12-16-2010 |
20100297906 | METHODS FOR ELECTROSPINNING HYDROPHOBIC COAXIAL FIBERS INTO SUPERHYDROPHOBIC AND OLEOPHOBIC COAXIAL FIBER MATS - Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a sheath outlet, ejecting an electrospinnable core solution from the core outlet of the electrospinning coaxial nozzle, ejecting a hydrophobic sheath solution from the sheath outlet of the electrospinning coaxial nozzle, wherein the hydrophobic sheath solution annularly surrounds the core solution, applying a voltage between the electrospinning coaxial nozzle and a collection plate, wherein the voltage induces a jet of the electrospinnable core solution annularly surrounded by the hydrophobic sheath solution to travel from the electrospinning coaxial nozzle to the collection plate to form the hydrophobic coaxial fiber comprising an electrospinnable polymer core coated with a hydrophobic sheath material, and wherein collection of the hydrophobic coaxial fiber on the collection plate yields the superhydrophobic coaxial fiber mat. | 11-25-2010 |
20100291382 | SILANE COMPOSITIONS AND METHODS FOR BONDING RUBBER TO METALS - Compositions and methods for treating metal substrates and/or bonding metal substrates to polymeric materials, such as rubber, are provided. The compositions include at least one substantially hydrolyzed amino silane and at least one substantially hydrolyzed sulfur-containing silane Optionally, the compositions include a nano-size particulate material. The compositions provide coatings on metal substrates for protecting the metal from corrosion and for adhering rubber-like polymeric compositions to the metal with polymer-to-metal vulcanization conditions less dependent on the coating thickness, and with use of less coating materials. | 11-18-2010 |
20100263723 | Nearly Index-Matched Luminescent Glass-Phosphor Composites For Photonic Applications - A light emitting composite material ( | 10-21-2010 |
20100254955 | SURGICAL DEVICE FOR SKIN THERAPY OR TESTING - A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin. The device contains cultured dermal and epidermal cells on a biocompatible, biodegradable reticulated matrix. All or part of the cells may be autologous, from the recipient of the cultured skin device, which advantageously eliminates concerns of tissue compatibility. The cells may also be modified genetically to provide one or more factors to facilitate healing of the engrafted skin replacement, such as an angiogenic factor to stimulate growth of blood vessels. The inventive device is easy to handle and manipulate for surgical transplant, can be made into large sheets to minimize the number of grafts required to cover a large surface area to be treated, and can be produced within the time frame to treat a burned individual requiring a skin graft. | 10-07-2010 |
20100208328 | Electrofluidic Devices, Visual Displays, And Methods For Making And Operating Such Elecrofluidic Devices - Electrofluidic devices, visual displays formed from the electrofluidic devices, and methods for making and operating such electrofluidic devices Each electrofluidic device has a fluid vessel with first and second regions that contain an electrically conductive polar fluid and a non-polar fluid The polar and/or the non-polar fluids are externally visible external through a viewable area of the second region A voltage source is electrically connected to a capacitor having a hydrophobic surface that contacts the polar fluid and provides a first principal radius of curvature of the polar fluid that is convex and smaller than a second principal radius of curvature of the polar fluid in the first region The voltage source applies an electromechanical force to the polar fluid, thereby transferring the polar fluid from the first region to the second region and causing a spectral property of light transferred through the viewable area to change | 08-19-2010 |
20100180765 | CONTINUOUS DROPLET GENERATOR DEVICES AND METHODS - Continuous droplet generators and methods are provided. In one embodiment, a continuous droplet generator includes an outer housing that defines a working liquid reservoir configured to maintain a working liquid. The continuous droplet generator also includes one or more heaters configured to change the phase of the working liquid and an evaporation-condensation tube positioned at least partially within the outer housing. The evaporation-condensation tube includes a gas inlet configured to receive a particle-containing gas flow, a gas outlet configured to export generated condensed droplets, a wall, an outer wall surface configured to be in contact with the working liquid, and an inner wall surface in contact with the particle-containing gas flow. The vapor is transported to the particle-containing gas flow through the evaporation-condensation tube by diffusion and vapor pressure difference to increase a relative humidity and grow particles within the particle-containing gas flow by nuclei heterogeneous condensation. | 07-22-2010 |
20100139486 | Sulfur Tolerant Highly Durable CO2 Sorbents - A sorbent for the capture of carbon dioxide from a gas stream is provided, the sorbent containing calcium oxide (CaO) and at least one refractory dopant having a Tammann temperature greater than about 530° C., wherein the refractory dopant enhances resistance to sintering, thereby conserving performance of the sorbent at temperatures of at least about 530° C. Also provided are doped CaO sorbents for the capture of carbon dioxide in the presence of SO | 06-10-2010 |
20100023307 | METHODS FOR PROGNOSING MECHANICAL SYSTEMS - A method of prognosing a mechanical system to predict when a failure may occur is disclosed. Measurement data corresponding to the mechanical system is used to extract one or more features by decomposing the measurement data into a feature space. A prediction model is then selected from a plurality of prediction models for the one or more features based at least on part on a degradation status of the mechanical system and a reinforcement learning model. A predicted feature space is generated by applying the selective prediction model to the feature space as well as a confidence value by comparing the predicted feature space with a normal baseline distribution, a faulty baseline distribution, or a combination thereof. A status of mechanical system based at least in part on the confidence value is then provided. | 01-28-2010 |
20090232509 | ELECTROWETTING RETROREFLECTOR DEVICES, SYSTEMS, AND METHODS - Switchable retroreflector devices that are modulated via electrowetting. The devices include an electrically-conductive polar fluid and a non-polar fluid that is immiscible with the polar fluid. The polar and the non-polar fluids differ in at least one optical property. The fluids are contained in a fluid vessel, or an array of fluid vessels. The fluids are at least partially viewable. A voltage source is configured to selectively apply an electromechanical force to the polar fluid causing repositioning and/or geometrical change of the fluids such that retroreflection in created, or suppressed, by optical refraction or by optical attenuation. | 09-17-2009 |
20090220964 | METHODS FOR DIAGNOSING AND TREATING CANCERS VIA MANIPULATIONS OF A...PATHWAY - Methods for diagnosing, treating, and screening for cancer based on manipulations of a newly discovered pVHL dependent, non-degradative ubiquitylation pathway of Rpb1. In particular, methods comprising the use of biomarkers implicating the pathway, and promoters of either or both of P1465 hydroxylation and CTD Ser-5 phosphorylation of Rpb1. Specifically, the methods may be used to inhibit tumor growth, including, in particular, carcinomas such as renal clear cell carcinoma. | 09-03-2009 |
20090203131 | Polyamides for nucleic acid delivery - The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA containing a sequence or sequences that act as transcription factor decoys. | 08-13-2009 |
20090124534 | Trehalose Click Polymers for Delivery of Biologically Active Molecules - Novel trehalose click polymers have in vitro and in vivo application in the cellular delivery of biologically active molecules, including nucleic acids and polypeptides. The trehalose click polymers of the present invention provide increased stability in serum as compared with other non-viral vectors, and are particularly useful in protecting nucleic acids against degradation. | 05-14-2009 |
20080287892 | Wound treatment system - A wound treatment system includes a sponge including a first surface adapted to confront a wound bed of a patient, a drape in contact with a second surface of the sponge, and a vacuum source for distributing a vacuum force through the sponge. The system also includes a wound separator having a sidewall defining an interior chamber, wherein at least a portion of an exterior of the sidewall confronts at least an interior portion of the sponge. An ostomy appliance is operatively connected to the wound separator to receive substances passing out of the wound separator. | 11-20-2008 |
20080269894 | Prosthetic Anchor and Method of Making Same - The present invention is directed towards a prosthetic anchor ( | 10-30-2008 |
20080260865 | Methods for Treating Bacterial Respiratory Tract Infections in an Individual Using Acidified Nitrite - Methods for treating bacterial respiratory tract infections in an individual comprise administering a therapeutic amount of nitrite composition having a pH of less than 7, and in specific embodiments, a pH of about 5.5-6.5, to the individual. The individual may be a pulmonary disease diagnosed individual and/or the infection may be at least in part caused by mucoid mucA mutant | 10-23-2008 |