| UNIVERSITY OF CINCINNATI Patent applications |
| Patent application number | Title | Published |
|---|
| 20120135211 | MULTIFUNCTIONAL NANOCOATINGS WITH MIXED NANOPARTICLES AND PROCESS FOR FABRICATING SAME - Embodiments of a coated substrate comprise a substrate ( | 05-31-2012 |
| 20120130288 | ULTRASOUND-MEDIATED INDUCEMENT, DETECTION, AND ENHANCEMENT OF STABLE CAVITATION - Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes providing a determined level of ultrasonic energy and detecting a scattered level of ultrasonic energy. The system for inducing and passively detecting stable cavitation includes a dual-element annular transducer array configured to provide a fundamental ultrasonic frequency and to detect an ultrasonic frequency that is a derivative of the fundamental frequency. The method of enhancing stable cavitation includes administering a nucleating agent and a thrombolytic agent to a treatment zone, providing a determined level of ultrasonic energy, and detecting a scattered level of ultrasonic energy. | 05-24-2012 |
| 20120128654 | Allantoin Administration for the Treatment of Neurodegenerative Disease and Neurotrauma - Methods for inhibiting the progression of neurodegenerative diseases and treating neurotrauma-induced damage and cerebrovascular disease are provided herein, the methods including the administration of a safe and effective amount of allantoin to a patient in need thereof. Also provided are pharmaceutical compositions including allantoin for the inhibition of the progression of neurodegenerative diseases and for the treatment of neurotrauma-induced damage and cerebrovascular disease. | 05-24-2012 |
| 20120093947 | METHOD OF TREATING REACTIVE AIRWAY DISEASE - A method of treating a reactive airway disease in a subject comprising administering at least one peroxidase inhibitor in association with administration of at least one β-agonist. | 04-19-2012 |
| 20120081777 | ELECTROFLUIDIC IMAGING FILM, DEVICES, AND DISPLAYS, AND METHODS OF MAKING AND USING THE SAME - A device and method of making and using the same. The device includes first and second substrates that are spaced to define a fluid space. Polar and non-polar fluids occupy the fluid space. A first electrode, with a dielectric layer, is positioned on the first substrate and electrically coupled to at least one voltage source, which is configured to supply an electrical bias to the first electrode. The fluid space includes at least one fluid splitting structure that is configured to facilitate the movement of the non-polar fluid into a portion of the polar fluid. Fluid splitting structure assisted movement of the non-polar fluid splits the polar fluid. | 04-05-2012 |
| 20120010234 | USE OF VEGF-D IN THE DIAGNOSIS OF LYMPHANGIOLEIOMYOMATOSIS (LAM) DISEASE - Described herein are methods of diagnosing lymphangioleiomyomatosis (LAM) that permits differentiating LAM from another lung disorder. Methods of treatment are also provided. | 01-12-2012 |
| 20110189260 | USE OF ZINC CHELATORS TO INHIBIT BIOFILM FORMATION - A method is provided for inhibiting formation of a biofilm of bacteria, the method including contacting the bacteria with an effective amount of at least one zinc chelator, wherein the bacteria contain at least one zinc adhesion module, whereby formation of the biofilm is inhibited. A method for inhibiting biofilm formation on a device and a topical pharmaceutical composition for the inhibition of biofilm formation are also provided. | 08-04-2011 |
| 20110136153 | Use of VEGF-D in the Diagnosis of Lymphangioleiomyomatosis (LAM) Disease - Described herein are methods of diagnosing lymphangioleiomyomatosis (LAM) that permits differentiating LAM from another lung disorder. Methods of treatment are also provided. | 06-09-2011 |
| 20110129461 | Mat II Beta Subunit RNAi and Therapeutic Methods Using Same - The presently disclosed subject matter generally relates to methods and compositions for modulating MAT II activity. More particularly, the presently disclosed subject matter relates to methods and compositions for inhibiting the expression of MAT II β subunit in a subject via RNAi by administering siRNA or shRNA molecules directed to MAT II β subunit. In some embodiments, the methods and compositions of the presently disclosed subject matter generally relates to the treatment of cancer. More particularly, the methods and compositions of the presently disclosed subject matter relates to the inhibition of MAT II β subunit for the treatment of leukemia. | 06-02-2011 |
| 20110096327 | Spiral Microchannel Particle Separators, Straight Microchannel Particle Separators, and Continuous Particle Separator and Detector Systems - A spiral microchannel particle separator includes an inlet for receiving a solution containing particles, at least two outlets, and a microchannel arranged in a plurality of loops. Particles within a solution flowing through the spiral microchannel experience a lift force F | 04-28-2011 |
| 20110066391 | METHODS AND SYSTEMS FOR ENERGY PROGNOSIS - In one embodiment, a method for managing an industrial process wherein a processor transforms electronic data into an energy prognosis is provided. An energy related test signal including effective power test data indicative of electrical energy consumed by an energy consuming machine may be received. The energy related test signal may be partitioned into an energy related test sub-signal. Mathematical functions may be applied to the energy related test sub-signal to extract a feature set of data from the energy related test sub-signal. The feature set of data may be transformed with a transformation matrix into a reduced test feature set. The reduced test feature set may be input into a performance assessment algorithm based at least in part upon a reduced training feature set derived from data indicative of electrical energy consumed during healthy operation. A power-based performance index may be generated with the performance assessment algorithm. | 03-17-2011 |
| 20110003844 | REGULATION OF CARDIAC CONTRACTILITY AND HEART FAILURE PROPENSITY - The methods and compositions of the present invention find use in altering expression of PKCα in transgenic animals. The compositions of the invention include isolated transgenic animal cells, transgenic tissue, transgenic animals, and transgenic mice. The transgenic animals of the invention exhibit altered PKCα activity. The methods allow generation of transgenic animals with altered expression of PKCα. The invention allows modulation of cardiac contractility. In particular, the invention provides a method for altering the susceptibility of a transgenic animal to cardiomyopathy. A transgenic animal of the invention finds use in identifying anti-cardiomyopathic compounds. | 01-06-2011 |
| 20100324075 | THERAPEUTIC USE OF CARBOXYL ESTER LIPASE INHIBITORS - Compounds, pharmaceutical compositions, and their methods of use in raising serum HDL levels in subjects in need thereof are provided. Also provided are compounds, pharmaceutical compositions, and their methods of use in increasing reverse cholesterol transport in subjects in need thereof. Finally, methods for treating disease by raising serum HDL levels and increasing reverse cholesterol transport are provided. | 12-23-2010 |
| 20100317536 | CRYSTAL STRUCTURE OF HUMAN GPVI AND APPLICATIONS THEREOF - A crystal comprising the collagen binding domain of human GPVI is provided and defined by structural atomic coordinates. Employing computer modeling based on the crystal structure, including methods for identifying inhibitors of GPVI collagen binding activity, methods for screening libraries of compounds for potential to bind to the GPVI collagen binding domain, and methods of identifying a compound useful for the treatment of a GPVI-mediated disorder, are also provided. | 12-16-2010 |
| 20100297906 | METHODS FOR ELECTROSPINNING HYDROPHOBIC COAXIAL FIBERS INTO SUPERHYDROPHOBIC AND OLEOPHOBIC COAXIAL FIBER MATS - Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a sheath outlet, ejecting an electrospinnable core solution from the core outlet of the electrospinning coaxial nozzle, ejecting a hydrophobic sheath solution from the sheath outlet of the electrospinning coaxial nozzle, wherein the hydrophobic sheath solution annularly surrounds the core solution, applying a voltage between the electrospinning coaxial nozzle and a collection plate, wherein the voltage induces a jet of the electrospinnable core solution annularly surrounded by the hydrophobic sheath solution to travel from the electrospinning coaxial nozzle to the collection plate to form the hydrophobic coaxial fiber comprising an electrospinnable polymer core coated with a hydrophobic sheath material, and wherein collection of the hydrophobic coaxial fiber on the collection plate yields the superhydrophobic coaxial fiber mat. | 11-25-2010 |
| 20100291382 | SILANE COMPOSITIONS AND METHODS FOR BONDING RUBBER TO METALS - Compositions and methods for treating metal substrates and/or bonding metal substrates to polymeric materials, such as rubber, are provided. The compositions include at least one substantially hydrolyzed amino silane and at least one substantially hydrolyzed sulfur-containing silane Optionally, the compositions include a nano-size particulate material. The compositions provide coatings on metal substrates for protecting the metal from corrosion and for adhering rubber-like polymeric compositions to the metal with polymer-to-metal vulcanization conditions less dependent on the coating thickness, and with use of less coating materials. | 11-18-2010 |
| 20100263723 | Nearly Index-Matched Luminescent Glass-Phosphor Composites For Photonic Applications - A light emitting composite material ( | 10-21-2010 |
| 20100254955 | SURGICAL DEVICE FOR SKIN THERAPY OR TESTING - A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin. The device contains cultured dermal and epidermal cells on a biocompatible, biodegradable reticulated matrix. All or part of the cells may be autologous, from the recipient of the cultured skin device, which advantageously eliminates concerns of tissue compatibility. The cells may also be modified genetically to provide one or more factors to facilitate healing of the engrafted skin replacement, such as an angiogenic factor to stimulate growth of blood vessels. The inventive device is easy to handle and manipulate for surgical transplant, can be made into large sheets to minimize the number of grafts required to cover a large surface area to be treated, and can be produced within the time frame to treat a burned individual requiring a skin graft. | 10-07-2010 |
| 20100208328 | Electrofluidic Devices, Visual Displays, And Methods For Making And Operating Such Elecrofluidic Devices - Electrofluidic devices, visual displays formed from the electrofluidic devices, and methods for making and operating such electrofluidic devices Each electrofluidic device has a fluid vessel with first and second regions that contain an electrically conductive polar fluid and a non-polar fluid The polar and/or the non-polar fluids are externally visible external through a viewable area of the second region A voltage source is electrically connected to a capacitor having a hydrophobic surface that contacts the polar fluid and provides a first principal radius of curvature of the polar fluid that is convex and smaller than a second principal radius of curvature of the polar fluid in the first region The voltage source applies an electromechanical force to the polar fluid, thereby transferring the polar fluid from the first region to the second region and causing a spectral property of light transferred through the viewable area to change | 08-19-2010 |
| 20100180765 | CONTINUOUS DROPLET GENERATOR DEVICES AND METHODS - Continuous droplet generators and methods are provided. In one embodiment, a continuous droplet generator includes an outer housing that defines a working liquid reservoir configured to maintain a working liquid. The continuous droplet generator also includes one or more heaters configured to change the phase of the working liquid and an evaporation-condensation tube positioned at least partially within the outer housing. The evaporation-condensation tube includes a gas inlet configured to receive a particle-containing gas flow, a gas outlet configured to export generated condensed droplets, a wall, an outer wall surface configured to be in contact with the working liquid, and an inner wall surface in contact with the particle-containing gas flow. The vapor is transported to the particle-containing gas flow through the evaporation-condensation tube by diffusion and vapor pressure difference to increase a relative humidity and grow particles within the particle-containing gas flow by nuclei heterogeneous condensation. | 07-22-2010 |
| 20100139486 | Sulfur Tolerant Highly Durable CO2 Sorbents - A sorbent for the capture of carbon dioxide from a gas stream is provided, the sorbent containing calcium oxide (CaO) and at least one refractory dopant having a Tammann temperature greater than about 530° C., wherein the refractory dopant enhances resistance to sintering, thereby conserving performance of the sorbent at temperatures of at least about 530° C. Also provided are doped CaO sorbents for the capture of carbon dioxide in the presence of SO | 06-10-2010 |
| 20100023307 | METHODS FOR PROGNOSING MECHANICAL SYSTEMS - A method of prognosing a mechanical system to predict when a failure may occur is disclosed. Measurement data corresponding to the mechanical system is used to extract one or more features by decomposing the measurement data into a feature space. A prediction model is then selected from a plurality of prediction models for the one or more features based at least on part on a degradation status of the mechanical system and a reinforcement learning model. A predicted feature space is generated by applying the selective prediction model to the feature space as well as a confidence value by comparing the predicted feature space with a normal baseline distribution, a faulty baseline distribution, or a combination thereof. A status of mechanical system based at least in part on the confidence value is then provided. | 01-28-2010 |
| 20090232509 | ELECTROWETTING RETROREFLECTOR DEVICES, SYSTEMS, AND METHODS - Switchable retroreflector devices that are modulated via electrowetting. The devices include an electrically-conductive polar fluid and a non-polar fluid that is immiscible with the polar fluid. The polar and the non-polar fluids differ in at least one optical property. The fluids are contained in a fluid vessel, or an array of fluid vessels. The fluids are at least partially viewable. A voltage source is configured to selectively apply an electromechanical force to the polar fluid causing repositioning and/or geometrical change of the fluids such that retroreflection in created, or suppressed, by optical refraction or by optical attenuation. | 09-17-2009 |
| 20090220964 | METHODS FOR DIAGNOSING AND TREATING CANCERS VIA MANIPULATIONS OF A...PATHWAY - Methods for diagnosing, treating, and screening for cancer based on manipulations of a newly discovered pVHL dependent, non-degradative ubiquitylation pathway of Rpb1. In particular, methods comprising the use of biomarkers implicating the pathway, and promoters of either or both of P1465 hydroxylation and CTD Ser-5 phosphorylation of Rpb1. Specifically, the methods may be used to inhibit tumor growth, including, in particular, carcinomas such as renal clear cell carcinoma. | 09-03-2009 |
| 20090203131 | Polyamides for nucleic acid delivery - The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA containing a sequence or sequences that act as transcription factor decoys. | 08-13-2009 |
| 20090124534 | Trehalose Click Polymers for Delivery of Biologically Active Molecules - Novel trehalose click polymers have in vitro and in vivo application in the cellular delivery of biologically active molecules, including nucleic acids and polypeptides. The trehalose click polymers of the present invention provide increased stability in serum as compared with other non-viral vectors, and are particularly useful in protecting nucleic acids against degradation. | 05-14-2009 |
| 20080287892 | Wound treatment system - A wound treatment system includes a sponge including a first surface adapted to confront a wound bed of a patient, a drape in contact with a second surface of the sponge, and a vacuum source for distributing a vacuum force through the sponge. The system also includes a wound separator having a sidewall defining an interior chamber, wherein at least a portion of an exterior of the sidewall confronts at least an interior portion of the sponge. An ostomy appliance is operatively connected to the wound separator to receive substances passing out of the wound separator. | 11-20-2008 |
| 20080269894 | Prosthetic Anchor and Method of Making Same - The present invention is directed towards a prosthetic anchor ( | 10-30-2008 |
| 20080260865 | Methods for Treating Bacterial Respiratory Tract Infections in an Individual Using Acidified Nitrite - Methods for treating bacterial respiratory tract infections in an individual comprise administering a therapeutic amount of nitrite composition having a pH of less than 7, and in specific embodiments, a pH of about 5.5-6.5, to the individual. The individual may be a pulmonary disease diagnosed individual and/or the infection may be at least in part caused by mucoid mucA mutant | 10-23-2008 |
