| UNIVERSITY OF CHICAGO Patent applications |
| Patent application number | Title | Published |
|---|
| 20120114686 | COMPOSITIONS AND METHODS RELATED TO PROTEIN A (SPA) VARIANTS - Disclosed are methods and compositions for treating or preventing a | 05-10-2012 |
| 20110262477 | Compositions and Methods Related to Bacterial EAP, EMP, and/or ADSA Proteins - The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a | 10-27-2011 |
| 20110250278 | PARTICLES CONTAINING AN OPIOID RECEPTOR ANTAGONIST AND METHODS OF USE - Particles comprising an opioid receptor antagonist as well as methods of their use and methods of their preparation are provided herein. Such particles may be used for treating and preventing opioid-induced side effects in patients, and may be provided to chronic opioid users as well. | 10-13-2011 |
| 20110207126 | CELL-BASED SCREEN FOR AGENTS USEFUL FOR REDUCING NEURONAL DEMYELINATION OR PROMOTING NEURONAL REMYELINATION - This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in the present invention are particularly useful for drug screening and/or treatment of demyelination disorders. | 08-25-2011 |
| 20110206676 | COMPOSITIONS AND METHODS RELATED TO STAPHYLOCOCCAL BACTERIUM PROTEINS - The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a | 08-25-2011 |
| 20110160174 | Method Of Treating Disorder Related To High Cholesterol Concentration - A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): | 06-30-2011 |
| 20110143963 | MOLECULAR AFFINITY CLAMP TECHNOLOGY AND USES THEREOF - The invention provides a molecular affinity clamp. The architecture of the affinity clamp is modular with two biorecognition modules, each capable of binding a target motif. The first biorecognition module has a recognition domain that possesses inherent or natural specificity for the target motif. The second biorecognition module also has a recognition domain that binds the motif. The two biorecognition modules are tethered together either directly, e.g., via a peptide bond between the two modules, or indirectly, e.g., via a linker moiety or linker. | 06-16-2011 |
| 20100333235 | Plant Centromere Compositions - The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells. | 12-30-2010 |
| 20100281548 | Animal models for demyelination disorders - This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in the present invention are particularly useful for drug screening and/or treatment of demyelination disorders. | 11-04-2010 |
| 20100249064 | METHODS AND COMPOSITIONS FOR TREATING DISEASES AND CONDITIONS INVOLVING HIGHER MOLECULAR WEIGHT HYALURONAN - The present invention concerns methods and compositions involving hyaluronan that has been substantially purified to enrich for hyaluronan with a molecular weight above 500 kilodaltons. This hyaluronan can be used for diseases and conditions characterized or caused by increased vascular permeability or angiogenesis. The higher molecular weight hyaluronan restores vascular integrity and inhibits angiogenesis in embodiments of the invention. | 09-30-2010 |
| 20100248371 | METHODS AND COMPOSITIONS FOR MODULATING RAD51 AND HOMOLOGOUS RECOMBINATION - The present invention concerns methods and compositions involving inhibitors and enhancers of RAD51, a protein involved in homologous recombination. In some embodiments, the present invention concerns methods for stimulating homologous recombination, which has a number of significant research and clinical applications. In certain other embodiments, there are methods for protecting cells using a compound that enhances RAD51 activity. Such enhancers may also be employed to prevent or reduce damage to cells that may be caused by DNA damaging agents. In other embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 enhancer or inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation. | 09-30-2010 |
| 20100093687 | Method Of Treating Disorder Related To High Cholesterol Concentration - A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): | 04-15-2010 |
| 20090062900 | Devices, systems and methods to detect endothelialization of implantable medical devices - An implantable medical device including a radially-expandable body and an attached detection device. The detection device includes a sensor positioned on a surface of the radially-expandable body and configured to detect endothelialization of the surface. The detection device also includes a transmitter and a receiver. Systems incorporating the implantable medical device and methods of using the device are also disclosed. | 03-05-2009 |
| 20090053690 | SURFACE CHEMISTRY AND DEPOSITION TECHNIQUES - Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface attachment features that are spaced apart on the surface such that when the analytes are labeled adjacent analytes are optically resolvable from each other. One way to express this concept is that binding elements should be spaced apart such that the Guassian point spread functions of adjacent labels do not overlap. Another way of expressing this concept is that the surface binding elements should be spaced apart by a distance equal to at least the diffraction limit for an optical label attached to the bound analytes. | 02-26-2009 |
| 20090029223 | PROTON CONDUCTING ELECTROLYTE - A cationic conductive polymer is described herein which generally comprises a proton donating polymer and an oxocarbonic acid. The cationic conductive polymer exhibits a high conductivity in low humidity environments. | 01-29-2009 |
| 20090017452 | METHODS AND COMPOSITIONS RELATING TO THE PHARMACOGENETICS OF DIFFERENT GENE VARIANTS - The present invention is directed to methods and compositions for determining the presence or absence of polymorphisms within an ABCC2, UGT1A1, and/or SLCO1B1 gene and correlating these polymorphisms with activity levels of their gene products and making evaluations regarding the effect on their substrates, particularly those substrates that are drugs. In addition, there are methods and compositions of evaluating the risk of an individual for developing toxicity or adverse event(s) to an ABCC2, UGT1A1, and/or SLCO1B1 substrate. In some embodiments, the invention concerns methods and compositions for determining the presence or absence of ABCC2 3972C>T variant and predicting or anticipating the level of activity of ABCC2 and determining dosages of an ABCC2 drug substrate, such as irinotecan, in a patient. Such methods and compositions can be used to evaluate whether irinotecan-based therapy, or therapy involving other ABCC2 substrates, may pose toxicity problems if given to a particular patient or predicting their efficacy. Alterations in suggested therapy may ensue based on genotyping results. | 01-15-2009 |
| 20080280179 | NOVEL ELECTROLYTE UTILIZING A LEWIS ACID/BRONSTEAD ACID COMPLEX - A proton conducting polymer is described herein which generally comprises a proton donating polymer and a Lewis acid. The Lewis acids may comprise one or more rare earth triflates. The proton conducting polymer exhibits excellent proton conductivity in low humidity environments. | 11-13-2008 |
