| UNIVERSITY OF BRISTOL Patent applications |
| Patent application number | Title | Published |
|---|
| 20110189284 | Peptide Fibres - This invention relates to protein fibrils, to methods and kits of producing those protein fibrils comprising a plurality of first peptide monomer units arranged in a first strand and a plurality of second peptide monomer units arranged in a second strand in which said first and second strands form an overlapping staggered heterodimer coiled coil structure, and wherein the amino acid residues on the exposed surface of said first and second strands enable said protein fibril to interact with another protein fibril in a plurality of non-parallel orientations. This invention also relates to bundles of protein fibrils and matrices, in particular, hydrogels produced using those protein fibrils. | 08-04-2011 |
| 20110023185 | Novel Plant Acyltransferases Specific For Long-Chained, Multiply Unsaturated Fatty Acids - The invention relates to a process for the production of long-chain polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids coding for polypeptides with acyltransferase activity. These nucleic acid sequences, if appropriate together with further nucleic acid sequences coding for polypeptides of the fatty acid or lipid metabolism biosynthesis, can advantageously be expressed in the organism. Furthermore, the invention relates to a method for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids. The invention furthermore relates to the nucleic acid sequences, and constructs, vectors and organisms comprising the nucleic acid sequences. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention and to their use. | 01-27-2011 |
| 20100305034 | GROWTH FACTOR ISOFORM - An isolated VEGF polypeptide having anti-angiogenic activity, said polypeptide including the amino acid sequence of SEQ.ID NO.1, or variants thereof. | 12-02-2010 |
| 20100272733 | ANTIBODIES SPECIFIC TO PRO-ANGIOGENIC ISOFORMS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) - The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, against agonist pro-angiogenic, pro-permeability, vasodilatory isoforms of VEGF. Disclosed antibodies and antibody fragments are characterized by being capable of binding to and neutralizing pro-angiogenic forms of VEGF while not effecting isoforms of VEGF which are anti angiogenic. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided. | 10-28-2010 |
| 20100210527 | PRO- AND ANTI-ANGIOGENIC TREATMENTS - The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favours proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favours distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment. | 08-19-2010 |
| 20100047290 | FUNCTIONAL PROTEIN CRYSTALS CONTAINING A CORE NANO-PARTICLE AND USES THEREOF - A functional protein crystal, wherein each protein in the crystal comprises a cavity containing a core nano-particle, the core nano-particle formed from an elemental metal, a metal alloy, or a metal compound, with the proviso that the protein is not apoferritin Dpr or | 02-25-2010 |
