| UNIVERSITY OF BASEL Patent applications |
| Patent application number | Title | Published |
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| 20120107938 | METHODS AND KITS FOR HIGH EFFICIENCY ENGINEERING OF CONDITIONAL MOUSE ALLELES - The present invention concerns methods and kits for the direct, targeted engineering of conditional alleles in rodent embryonic stem cells in which the conditional allele is replaced with a DNA of interest without first introducing heterotypic recombination sites, thus providing high efficiency targeted exchange of genetic material. | 05-03-2012 |
| 20110275762 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES - The invention relates to novel therapeutic agents and diagnostic probes. The invention also relates to phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor triazine-, pyrimidine- and pyridine-based compoundŝ Formula (I), their stereoisomers, geometric isomers, tautomers, solvates, metabolites, N-oxide derivatives, pharmaceutically acceptable salts, and prodrugs thereof compositions of the new compounds; either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, for treating disorders mediated by lipid kinases. •Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. (Formula I) | 11-10-2011 |
| 20110123994 | SCREENING FOR COMPOUNDS HAVING IMMUNOSUPPRESSANT ACTIVITY BY TESTING IMPACT ON LEUKOCYTE-SPECIFIC CALCIUM FLUXES - The invention relates to an assay for the identification of a compound having immunosuppressant activity, wherein a candidate compound is analyzed whether it blocks the Ca | 05-26-2011 |
| 20110075916 | MODELING METHODS AND SYSTEMS - Methods and/or systems for modeling 3-dimensional objects (for example, human faces). In certain example embodiments, methods and/or systems usable for computer animation or static manipulation or modification of modeled images (e.g., faces), image processing, or for facial (or other object) recognition methods and/or systems. | 03-31-2011 |
| 20100239535 | METHOD FOR ISOLATING HOMOGENEOUS POPULATIONS OF TRANSDUCED PROGENITORS STABLY EXPRESSING SPECIFIC LEVELS OF A TRANSGENE - The invention is directed to a method for producing precursor cells expressing a target gene, for example VEGF, at desired levels comprising stably transducing precursor cells with the target gene linked to a cell-surface marker gene, for example truncated CD8/CD8 | 09-23-2010 |
| 20090239760 | Method for the Identification of New Leads for Drug Candidates - Disclosed is a method for producing new leads for drug candidates. The method employs a combinatorial approach for identifying high affinity ligands. The target may be unknown and/or may include one or more unknown binding sites. A method involving a combined screening and synthesis method for bi-site inhibitors is disclosed comprising: 1) determining if there is sufficient proximity between ligands binding to different sites of a target: e.g. by using spin-labelled ligands quenching can be measured with NMR if a first ligand and second allosteric ligand are in proximity 2) connecting both ligands having linkers, via in situ synthesis in the presence of the protein scaffold (e.g. target guided synthesis combined with fragment based self assembly). Click chemistry is a preferred embodiment here. Also disclosed are kits used in context of this method, leads discovered by the method and their use in drug development. Leads for drugs acting on myelin associated glycoprotein (MAG) have been identified and synthesised. | 09-24-2009 |
| 20090121148 | High Brightness Solid State Ion Beam Generator, its use, and Method for Making such a Generator - Ion sources or generators for focused ion beam emission (FIB) applications emitting ion beams into vacuum or a gas are used in industry and research for the characterization and processing of surfaces. With appropriate focusing, such ion beams can be confined to diameters of a few nanometers. The tip of technical FIB generators for producing such focused beams consists of a liquid metal, gallium in general, which tends to fluctuate during operation. This has a negative influence on the stability of the emission current and the focus definition. It is also possible to generate an FIB with solid tips, consisting of a solid metal, but such tips deteriorate rapidly during operation due to erosion of material from the tip apex. The present invention concerns a novel FIB source generating free space ion beams from a solid source but does not exhibit the above-mentioned erosion effect at the apex. The novel FIB generator consists of a combination of two essentially unitary bodies, a solid electrolyte body with a sharp tip and a solid ion reservoir body, both bodies having close contact with each other. The reservoir is made of or contains the same material, in general a metal as the mobile ions. Loss of ions from the electrolyte body due to emission is compensated by an inflow of ions from the reservoir body during operation. This practically preserves electro-neutrality which is a precondition for continuous mode operation. Erosion of the tip of the electrolyte body does not occur since the counter ions form a solid matrix and the emitted ions are replenished during operation. | 05-14-2009 |
| 20080272774 | Magnetic Resonance Method for the Detection and Imaging of Susceptibility Related Magnetic Field Distortions - Disclosed are methods and apparatuses for generating susceptibility-related contrast images, as induced, e.g., by marker material interventional devices used for passive MR-guided interventions, or by particles or cells loaded with marker materials used for molecular imaging, cell-tracking or cell-labeling. Near a local magnetic field perturber a positive contrast signal emanates from local gradient compensation to form, e.g., a balanced SSFP type of echo, whereas everywhere else echoes are shifted outside of the data acquisition window. | 11-06-2008 |
