| UNIVERSITY HEALTH NETWORK Patent applications |
| Patent application number | Title | Published |
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| 20120128132 | PHANTOM FOR CONTRAST IMAGING CALIBRATION - An imaging phantom for contrast imaging calibration. The phantom includes a body defining at least one cavity having a directional configuration corresponding to at least one pre-determined direction of motion of the phantom. The phantom also includes at least one imaging capsule configured to match and be contained in the at least one cavity. The imaging capsule comprises a material having an imaging contrast different from that of the body. | 05-24-2012 |
| 20120100999 | PROGNOSTIC GENE EXPRESSION SIGNATURE FOR SQUAMOUS CELL CARCINOMA OF THE LUNG - Provided is a gene expression signature consisting of 12 biomarkers for use in prognosing or classifying a subject with lung squamous cell carcinoma into a poor survival group or a good survival group. The 12-gene signature specific for squamous cell carcinoma consists of the biomarkers RPL22, VEGFA, G0S2, NES, TNFRSF25, DKFZP586P0123, COL8A2, ZNF3, PJPK5, RNFT2, ARHGEF12 and PTPN20A. | 04-26-2012 |
| 20120094900 | SENSITIZING AGENTS FOR CANCER THERAPY, METHODS OF USE AND METHODS FOR THE IDENTIFICATION THEREOF - There is provided herein methods, compounds and methods for identifying compounds, for sensitizing a subject with cancer to a cancer therapy by inhibiting or down-regulating UROD. | 04-19-2012 |
| 20120094329 | INCREASING PROTEIN PRODUCTION BY INCREASING ABC50 EXPRESSION OR ACTIVITY - The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell. ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of a cell to an endoplasmic reticulum stress agent such as Econozole by decreasing the level of ABC50. | 04-19-2012 |
| 20120045419 | METHODS AND USES OF HYPOXIC COMPARTMENT CELLS - The disclosure relates to methods of maintaining and/or expanding an in vitro population of hypoxia compartment cells comprising culturing said population of cells optionally in an oxygen controlled environment, wherein the population of hypoxia compartment cells is exposed to an oxygen concentration of between about 1.5% and about 10%, preferably between about 2% and about 5%, and uses of cells expanded according to these methods. | 02-23-2012 |
| 20110319427 | USE OF 5AHQ AND BORTEZOMIB FOR THE TREATMENT OF HEMATOLOGICAL DISEASES - The disclosure provides methods and compositions for treating hematological malignancies. In particular, the disclosure provides methods and compositions for treating leukemia, lymphoma and multiple myeloma using bortezomit and 5AHQ (5-ammo-8-hydroxyqumolme) and related compounds that bind non-competitively to an alpha unit of 2OS proteasome and inhibit proteasome activity Kits and commercial packages are also disclosed | 12-29-2011 |
| 20110280456 | METHOD OF SYNTHETIC IMAGE GENERATION FOR MAGNETIC RESONANCE IMAGING - A method, system and user interface for synthetic image generation for magnetic resonance (MR) imaging is described. A plurality of MR imaging data sets is received, each data set being acquired at a different value for a MR acquisition parameter. A response value for a particular property of tissues is determined, based on a calculated fit of each pixel to a property response model. A synthetic image is generated for a selected value of the MR acquisition parameter, based on the determined response value. An option is provided to dynamically change the selected value of the MR acquisition parameter and the synthetic image is re-generated for the changed value. An option may be provided to dynamically change the value. Another option may be provided to calculate a reliability measure for the synthetic image. | 11-17-2011 |
| 20110256560 | METHODS AND COMPOSITIONS FOR THE DETECTION OF OVARIAN CANCER - Provided is a method of screening for, diagnosing or detecting ovarian cancer in a subject comprising (a) determining a level of mdogen-2 in a test sample from the subject, and (b) comparing the level of mdogen-2 in the test sample with a control, where detecting an increase in the level of mdogen-2 in the test sample compared to the control is indicative of ovarian cancer in the subject. | 10-20-2011 |
| 20110212176 | CICLOPIROX AND CYTARABINE FOR THE TREATMENT OF LEUKEMIC DISORDERS - The present application relates to compositions and methods for treating leukemic disorders. In particular, the present application relates to compositions and methods for treating the leukemic disorders such as acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) using ciclopirox and cytarabine. | 09-01-2011 |
| 20110191085 | SYSTEM AND METHOD FOR COMMISSIONING OF A BEAM MODEL FOR A THREE DIMENSIONAL RADIATION THERAPY TREATMENT PLANNING SYSTEM - A system and method for commissioning of a beam model for a three dimensional radiation therapy treatment planning system is described. The system includes an intensity modulated radiotherapy (IMRT) unit for generating a two dimensional intensity modulated beam pattern, a two dimensional diode array for detecting a two dimensional dose map for the beam pattern, and a processor configured to execute instructions for iteratively adjusting one or more parameters for the beam model, in order to increase agreement between the detected dose map and a calculated dose map calculated using the beam model. | 08-04-2011 |
| 20110151580 | METHOD FOR THE DETECTION OF BREAST CANCER BY DETERMINING ALCAM AND/OR BCAM LEVELS IN A PATIENT - The present application describes biomarkers and methods useful for screening for, diagnosing or detecting the presence and severity of breast cancer in a subject. The present application also provides methods for determining the prognosis of a subject with breast cancer as well as methods for monitoring the therapeutic response to a breast cancer treatment or therapy. | 06-23-2011 |
| 20110150309 | METHOD AND SYSTEM FOR MANAGING IMAGING DATA, AND ASSOCIATED DEVICES AND COMPOUNDS - Methods, systems, devices and compounds for managing imaging data, such as time series imaging data. The method may include selecting a set of representative voxels from a plurality of voxels in the imaging data, and associating each representative voxel with a voxel database for storing information. For each given voxel in the time series imaging data, at least one corresponding representative voxel may be determined from the set of representative voxels, and information from the given voxel may be aggregated in the voxel database of the determined corresponding representative voxel. | 06-23-2011 |
| 20110129057 | METHOD FOR DETERMING A CORRECTION FUNCTION FOR CORRECTING COMPUTED TOMOGRAPHIC NUMBERS OF A SMALL TARGET OBJECT IN A CT IMAGE - A method of correcting target region in computed tomographic (CT) image, including the steps of obtaining a CT image of a patient; determining the size of a target object in the CT image; and correcting CT numbers of a portion of the CT image that corresponds to the target object, based on the determined size of the target object. | 06-02-2011 |
| 20110104130 | THYMIDYLATE KINASE FUSIONS AND USES THEREOF - The application relates to a composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) wherein the modified mammalian tmpk increases phosphorylation of a prodrug relative to phosophorylation of the prodrug by wild-type human tmpk; and a detection cassette fused to tmpk. The application also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer. | 05-05-2011 |
| 20110086089 | USE OF P27KIP1 FOR THE PREVENTION AND TREATMENT OF HEART FAILURE | 04-14-2011 |
| 20110052574 | METHOD OF INHIBITION OF LEUKEMIC STEM CELLS - A method for inhibition of leukemic stem cells expressing IL-3Rα; (CD 123), comprises contacting the cells with an antigen binding molecule comprising a Fc region or a modified Fc region having enhanced Fc effector function, wherein the antigen binding molecule binds selectively to IL-3Rα (CD123). The invention includes the treatment of a hematologic cancer condition in a patient by administration to the patient of an effective amount of the antigen binding molecule. | 03-03-2011 |
| 20110042580 | FLUORESCENCE QUANTIFICATION AND IMAGE ACQUISITION IN HIGHLY TURBID MEDIA - Various embodiments of methods and systems are described herein for the acquisition and quantification of fluorescence or luminescence signals from a region of interest of an object. The quantification of the acquired signals includes performing at least one ratiometric operation to correct these signals for artifacts due to various factors. | 02-24-2011 |
| 20110020358 | Methods and Compositions for Detecting Amyotrophic Lateral Sclerosis - The invention provides binding proteins that bind to misfolded or monomeric SOD1, and not to native homodimeric SOD1. The invention also includes methods of diagnosing, detecting or monitoring amyotrophic lateral sclerosis in a subject. In addition, the invention provides methods of identifying substances for the treatment or prevention of amyotrophic lateral sclerosis and kits using the binding proteins of the invention. | 01-27-2011 |
| 20110015174 | CYCLIC INHIBITORS OF CARNITINE PALMITOYLTRANSFERASE AND TREATING CANCER - A CPT1 inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. | 01-20-2011 |
| 20100297734 | Fusion Tag Comprising an Affinity Tag and an EF-Hand Motif Containing Polypeptide and Methods of Use Thereof - The application discloses a fusion tag comprising an affinity tag and a polypeptide comprising one or more EF hand motif(s). Preferably, said fusion tag comprises a polyhistidine tag, one or more EF hand motif(s) of calmodulin and a thrombin cleavage site. Methods of using said fusion tag to purify a polypeptide of interest are also disclosed. | 11-25-2010 |
| 20100291043 | IL-12 IMMUNOTHERAPY FOR CANCER - Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia. | 11-18-2010 |
| 20100288916 | PHANTOMS AND METHODS FOR VERIFICATION IN RADIOTHERAPY SYSTEMS - Methods and phantoms for verification in radiotherapy systems. A phantom for verification in a radiotherapy system may include a body to support a detector surface for obtaining a panoramic image of individual radiation beams in the radiotherapy system. The detector surface may be positioned in an intermediate region between the one or more sources and a target isocenter of the radiotherapy system. The detector surface may at least partially surround the target isocenter. | 11-18-2010 |
| 20100239578 | MODULATION OF SIRP-ALPHA - CD47 INTERACTION FOR INCREASING HUMAN HEMATOPOIETIC STEM CELL ENGRAFTMENT AND COMPOUNDS THEREFOR - The invention relates to modulating the SIRPα-CD47 interaction in order to increase hematopoietic stem cell engraftment and compounds therefor. In some embodiments, there is provided isolated SIRPα and CD47 polypeptides, fragments and fusion proteins for enhancing hematopoietic stem cell engraftment. Further there is provided methods for increasing hematopoietic stem cell engraftment through administration of the above polypeptides. | 09-23-2010 |
| 20100172838 | ENDOMETRIAL BIOMARKERS - Methods for detecting endometrial diseases or an endometrium phase in a subject are described comprising measuring endometrial markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for endometrial diseases, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for endometrial diseases employing endometrial markers, polynucleotides encoding the markers, and/or binding agents for the markers. | 07-08-2010 |
| 20100086951 | Pan-Kinase Activation and Evaluation of Signaling Pathways - Methods and reagents are provided for determining the activation state of a signal transduction pathway signaling protein. There exists a need in the art for methods that can monitor the efficacy of a signal transduction inhibitor in a patient. Other needs exist for detecting and monitoring certain disease or disorders that are associated with aberrant activation of a signal transduction pathway signaling protein. The present assay provides a highly sensitive assay that is also useful in patient populations in which obtaining a large cellular sample is difficult, for example, neonates. | 04-08-2010 |
| 20100056468 | Pyrimidine Derivatives As Anticancer Agents - The present invention includes methods of treating or preventing cancer by administering an effective amount of 6-substituted pyrimidine derivatives of the Formula I to a subject need thereof: | 03-04-2010 |
| 20100040540 | ANTI CD44 ANTIBODIES FOR ERADICATING LEUKAEMIC STEM CELLS AND BREAST CANCER STEM CELLS - The present invention provides the use of an anti-CD44 antibody, a (Fab′)2, Fab, Fab′ fragment thereof, an IgG or IgM isotype thereof, in a method for eradicating pathological stem cells in cancer therapy, and more specifically in breast cancer and leukaemia therapy. | 02-18-2010 |
| 20090286854 | APTAMERS DIRECTED TO MUCI - Aptamers against the glycosylated form of MUC1 are described, along with their use in treatment and diagnosis of conditions associated with elevated production of MUC1. | 11-19-2009 |
| 20090263389 | Use of TGF-Beta Antagonists to Treat or to Prevent Chronic Transplant Rejection - Effective use of a TGF-β antagonist to treat or to prevent loss of transplant function is described herein. Use of a TGF-β antagonist is demonstrated to effectively prevent loss of organ function in a host due to chronic rejection in which TGF-β-mediated fibroproliferation is a characteristic. Expression in situ of a TGF-β antagonist in the form of a recombinant receptor, i.e., TGF-β type III receptor (TGFBIIIR) showed prevention of bronchiolitis obliterans in comparison to untreated controls in a rat lung transplant model. This provides an effective method for preventing or inhibiting chronic rejection of transplant organs such as lung, kidney, liver and heart in vertebrate hosts including human hosts. | 10-22-2009 |
| 20090028931 | Liposomal compositions for parenteral delivery of agents - The invention provides methods and compositions for loading an agent, such as econazole, onto a liposome for parental delivery. The loading of the agent into a liposome comprises combining the agent with a micelle-forming compound to form a micelle including the agent, where the agent is releasable from the micelle-forming compound, and adding the micelle to the liposome, where the micelle combines with the liposome such that the agent is loaded into the liposome to form a loaded liposome. The methods are suitable for the loading of poorly soluble agents onto liposome. | 01-29-2009 |
| 20080285913 | Method and apparatus for high resolution coherent optical imaging - A method and an apparatus for examining the sub-surface microstructure of a sample are provided. Radiation from a plurality of optical radiation sources travels along a first optical path. In the first optical path, a device focuses the optical radiation from each of the optical sources into a plurality of respective focal points along the first optical path to provide substantially continuous coverage of a selected portion of the first optical path. Then, a sample on the first optical path within the selected length extending into the sample is scanned along said selected portion of the first optical path. | 11-20-2008 |
| 20080226554 | Methods For Detecting Markers Associated With Endometrial Disease or Phase - Methods for detecting endometrial diseases or an endometrium phase in a subject are described comprising measuring endometrial markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for endometrial diseases, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for endometrial diseases employing endometrial markers, polynucleotides encoding the markers, and/or binding agents for the markers. | 09-18-2008 |
| 20080206131 | Compositions and Method for Multimodal Imaging - Provided are signal modifying compositions for medical imaging comprising a carrier and two or more signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect to the signal modifying agents, which enables prolonged contrast imaging without significant depletion of the signal modifying agents from the carrier. The carriers of the present invention are lipid based or polymer based, the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal. | 08-28-2008 |
