| Universiteit Leiden Patent applications |
| Patent application number | Title | Published |
|---|
| 20120135070 | Copolymers - The invention provides a block copolypeptide comprising a hydrophilic heteropolypeptide block (A) and a hydrophobic homopolypeptide block (B). There is also provided a polymersome comprising a block copolypeptide of the invention. The invention further provides a method for preparing a copolymer comprising ring-opening polymerisation (ROP) of an amino acid N-carboxyanhydride (NCA) initiated from a peptide. | 05-31-2012 |
| 20120097272 | PHASEGUIDE PATTERNS FOR LIQUID MANIPULATION - The present invention relates to phaseguide patterns for use in fluid systems such as channels, chambers, and flow through cells. In order to effectively control filling and/or emptying of fluidic chambers and channels, techniques for a controlled overflowing of phaseguides are proposed. In addition, techniques of confined liquid patterning in a larger fluidic structure, including approaches for patterning overflow structures and the specific shape of phaseguides, are provided. The invention also proposes techniques to effectively rotate the advancement of a liquid/air meniscus over a certain angle. In particular, a phaseguide pattern for guiding a flow of a liquid contained within a compartment is provided, wherein an overflow of the phaseguide by a moving liquid phase is controlled by a local change in capillary force along the phaseguide, wherein said overflow by the liquid over the phaseguide is provoked at the position of the local change in capillary force. | 04-26-2012 |
| 20110296975 | APPARATUS COMPRISING A BASE AND A FINGER ATTACHMENT - Apparatus comprising a base, a finger attachment, and an electromagnet. The base comprises a proximity detector configured to determine an input distance between the finger attachment and the base. The apparatus further comprises a converter configured to convert the input distance between the finger attachment and the base into an output force to be applied to the finger attachment. The electromagnet is configured to apply a force to the finger attachment in accordance with the output force to be applied to the finger attachment as determined by the converter. | 12-08-2011 |
| 20110144156 | A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS - Provided are 2,4-disubstituted quinoline derivatives that are A3 adenosine receptor modulators (A | 06-16-2011 |
| 20110143394 | Methods and Means for Metabolic Engineering and Improved Product Formation by Micro-Organisms - The invention relates to the field of biochemistry, molecular biology and microbiology. More specific the invention relates to methods and means for metabolic engineering and improved product formation by a filamentous micro-organism or a low G+C gram-positive bacterium. | 06-16-2011 |
| 20110020430 | Novel mRNA splice variant of the doublecortin-like kinase gene and its use in cancer diagnosis and therapy - Methods for treating neuroblastoma in a subject are provided. The methods include administering to the subject nucleic acid that is capable of causing a significant reduction of the amount of doublecortin like protein (DCL) in the subject. The nucleic acids include antisense oligonucleotides and small interfering RNA. | 01-27-2011 |
| 20090311717 | MICROFLUIDIC CHIP DESIGN COMPRISING CAPILLARIES - The invention provides a microfluidic device wherein capillaries are connected to the microfluidic device by a deformable penetrable substance. | 12-17-2009 |
| 20090041734 | USE OF CELL IMPLANTS IN BLADDER AND GUT OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF PEPTIDES - Provided are means and method for the production of proteins in non-production in non-human animals. Cells producing a protein of interest is implanted in said non-human animal whereupon produced protein is harvested. In a preferred embodiment cells are implanted into a bladder or gut of said non-human animal | 02-12-2009 |
| 20080206872 | Nucleic acid integration in eukaryotes - The invention relates to methods for directing integration of a nucleic acid of interest towards homologous recombination and uses thereof. The present invention discloses factors involved in integration of a nucleic acid by illegitimate recombination which provides a method of directing integration of a nucleic acid of interest to a predetermined site, whereby the nucleic acid has a homology at or around the predetermined site, in a eukaryote with a preference for non-homologous recombination comprising steering an integration pathway towards homologous recombination. Furthermore, the invention provides a method of directing integration of a nucleic acid of interest to a subtelomeric and/or telomeric region in a eukaryote with a preference for non-homologous recombination. | 08-28-2008 |
