| UNIVERSITE DE STRASBOURG Patent applications |
| Patent application number | Title | Published |
|---|
| 20120121480 | MICROFLUIDIC DEVICES FOR RELIABLE ON-CHIP INCUBATION OF DROPLETS IN DELAY LINES - The present invention relates generally to droplet creation, fusion and sorting, and incubation for droplet-based microfluidic assays. More particularly, the present invention relates to delay-lines, which allow incubation of reactions for precise time periods. More particularly, the present invention relates to delay lines for incubations up to three hours, while reducing back-pressure and dispersion in the incubation time due to the unequal speeds with which droplets pass through the delay line. | 05-17-2012 |
| 20120115751 | METHOD OF PREPARING AN ADDUCT - A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, the molecular structure(s) each including one nucleotide chain onto which is hybridized at least one PNA-encoded molecule. | 05-10-2012 |
| 20120108721 | MICROFLUIDIC SYSTEM AND METHODS FOR HIGHLY SELECTIVE DROPLET FUSION - A method and chip for fusing droplets in a chip comprising (i) providing a first set of droplets which are partially or not stabilized by surfactant, (ii) providing a second set of droplets which are stabilized by surfactant, (iii) contacting each droplet of the first set with single or multiple droplets of the second set in a pairing module and (iv) fusing droplets of the first set with droplets of the second set through a droplet fusion module in which the droplets experience at least one acceleration and/or deceleration and/or reorientation and/or rearrangement in space and time. | 05-03-2012 |
| 20120101153 | ROCAGLAOL DERIVATIVES AS CARDIOPROTECTANT AGENTS AND AS ANTINEOPLASTIC AGENTS - The present invention discloses new rocaglaol derivatives and the use of rocaglaol derivatives to prevent or to limit the cardiotoxicity of an antineoplastic agent, in particular to prevent or to limit the apoptosis of cardiomyocytes induced by such agent. | 04-26-2012 |
| 20120082728 | MULTIFUNCTIONAL STEALTH NANOPARTICULES FOR BIOMEDICAL USE - The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and therapeutic properties respectively, as well as an optional fourth type of monomers with targeting properties. The present invention also relates to core-shell or hollow shell nanoparticles coated by an external layer of the copolymer according to the invention. Several types of core-shell nanoparticles are envisaged. The invention also concerns methods for preparing said nanoparticles, as well as pharmaceutical compositions or medicaments comprising them. | 04-05-2012 |
| 20120079768 | CATALYST FOR REFORMING TAR USED IN THE STEAM GASIFICATION OF BIOMASS - A catalyst includes an olivine substrate on which an iron compound layer is deposited, produced by impregnating the olivine substrate with a solution including an iron salt, and then heat-treating. The catalyst is useful for steam-reforming tar, in particular in gaseous media from the steam gasification of biomass. Further, the catalyst can be used alone for catalyzing the steam gasification of organic compounds from biomass while limiting the amount of tar produced in the synthesized gases. | 04-05-2012 |
| 20120077775 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 - Disclosed are macrocyclic compounds of formulae I-V, which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90. | 03-29-2012 |
| 20120035098 | NOVEL ANTIVIRAL AGENT - The present invention describes the use of a composition including or constituted by at least one element chosen from:
| 02-09-2012 |
| 20110294732 | ERYTHROPOLETIN COMPLEMENTATION OR REPLACEMENT - The present invention provides methods and compositions to replace up to 90% of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P | 12-01-2011 |
| 20110236347 | Monoclonal Anti-Claudin 1 Antibodies for the Inhibition of Hepatitis C Virus Infection - The present invention provides monoclonal antibodies that specifically bind to the extracellular domain of human Claudin-1 on the cell surface, thereby inhibiting HCV entry into susceptible cells and preventing HCV infection of these cells; and hybridoma cell lines which produce such monoclonal antibodies. Also provided are reagents that comprise such antibodies, and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing HCV infection by administration of an inventive monoclonal antibody, or a pharmaceutical composition thereof are also described. | 09-29-2011 |
| 20110223242 | NANOPARTICLES CONTAINING A PEPTIDE, VECTORS CONTAINING SAID NANOPARTICLES, AND PHARMACEUTICAL USES OF SAID NANOPARTICLES AND VECTORS - The invention relates to nanoparticles comprising a matrix containing at least one polysaccharide as well as the peptide P140 having the sequence SEQ ID NO: 1 or an analog thereof, said polysaccharide preferably being a polysaccharide bearing one or more negatively-charged functional groups. The invention also relates to a carrier for oral administration that comprises a carrier including at least one nanoparticle as defined above and either containing or not containing a dispersant. | 09-15-2011 |
| 20110217335 | SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS - Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90. | 09-08-2011 |
| 20110190237 | Macrocyclic Prodrug Compounds Useful as Therapeutics - The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative disease, cancer, a cardiovascular disease, allergy, asthma, a hormone-related disease, and tumors or symptoms resulting from neurofibromatosis. | 08-04-2011 |
| 20110189242 | ORAL GALENIC FORM, POLYMER PRODUCTION METHOD AND USE OF SAME - The polymers, according to the invention, comprise a polysaccharide block ( | 08-04-2011 |
| 20110184390 | DEVICE FOR THE CONTROLLED TRANSLATIONAL DISPLACEMENT OF AN ELONGATE ELEMENT - A device for controlled translational displacement of an elongated element that terminates in a frontal functional end, in particular an instrument or a tool that is designed to be brought to an internal site in a patient, more particularly an exploratory instrument or a surgical tool placed in a catheter or in an operating channel or working channel of a flexible endoscope, whereby the device includes a linear actuator that acts at the rear end of the elongated element that is located opposite its frontal functional end. Device ( | 07-28-2011 |
| 20110111514 | LABELLING REAGENTS HAVING A PYRIDINE NUCLEUS BEARING A DIAZOMETHYL FUNCTION, PROCESS FOR SYNTHESIS OF SUCH REAGENTS AND PROCESSES FOR DETECTION OF BIOLOGICAL MOLECULES - A process for synthesis of a labelling reagent, a process for the labelling of a biological molecule, a labelled biological molecule obtained by the process, a process for labelling and fragmentation of a single or double strand nucleic acid, a labelled nucleic acid capable of being obtained by the process, a kit for detection of a target nucleic acid containing a labelled nucleic acid, a solid support onto which is attached a reagent and a process for capture of nucleic acids. | 05-12-2011 |
| 20100311056 | METHOD FOR HYBRIDIZING NUCLEIC ACIDS - The invention relates to a method for manipulating, isolating, detecting or amplifying a target nucleic acid in a sample by hybridization with an oligonucleotide-oligocation conjugate, comprising allowing said nucleic acid to react with an oligonucleotide-oligocation conjugate comprising at least A1 and Bj linked together directly or via a linker, wherein. A, is an i-mer oligonucleotides, with i=3 to 50, where Ai is an oligomer with naturally or non naturally occurring nucleobases and/or pentafuranosyl groups and/or native phosphodiester bonds, optionally comprising a marker group. Bj is a j-mer organic oligocation moiety, with j=1 to 50, where B is —HPO | 12-09-2010 |
| 20100304378 | Method for Detecting or Quantifying a Truncating Mutation - The present invention discloses a new method for detecting or quantifying a truncating mutation of a target gene in a subject, said method relying on the in vitro compartmentalization of single genetic constructs in aqueous droplets of a water-in-oil emulsion. | 12-02-2010 |
| 20100267674 | CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN - The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease. | 10-21-2010 |
| 20100191095 | PROCESS, DEVICE AND SYSTEM FOR REDUCING THE ARTIFACTS THAT AFFECT ELECTROPHYSIOLOGICAL SIGNALS AND THAT ARE DUE TO ELECTROMAGNETIC FIELDS - A method for collecting and a device for sensing at least one electrophysiological signal, as well as to a system including at least one such device. The device for sensing at least one electrophysiological signal from a living subject subjected to at least one electromagnetic field, includes elements, such as electrodes, which are placed on the subject for the physical acquisition of at least one electrophysiological signal and at least elements for the pre-processing of the at least one sampled electrophysiological signal. The sensor device ( | 07-29-2010 |
| 20100168518 | FLEXIBLE ENDOSCOPE DEVICE WITH VISUAL CONTROL AND PROCESS FOR STABILIZATION OF SUCH A DEVICE - A flexible endoscope device includes an elongated flexible body having an end segment bearing or defining the endoscope head, and provided with an optical system that can be curved or bent in at least two mutually perpendicular directions, the elongated body being functionally connected at the other end thereof to a control element capable of controlling at least the movements and/or the arrangement of the end segment. The device includes automatic flexion and positioning elements of the end segment by visual control, the elements essentially including a video processing element for receiving the images or video signals provided by the optical system of the endoscope head using a computer element capable of carrying out visual control operations on the basis of the processed video signals and of transmitting control signals, and actuation members that are part of or associated with the control elements. | 07-01-2010 |
| 20100167957 | METHODS FOR PRODUCING ACTIVE SCFV ANTIBODIES AND LIBRARIES THEREFOR - The present disclosure describes scFv antibody libraries, antibodies isolated from the libraries, and methods of producing and using the same. | 07-01-2010 |
| 20100136538 | MARKING REAGENTS BEARING DIAZO AND NITRO FUNCTIONS, METHODS FOR THE SYNTHESIS OF SUCH REAGENTS AND METHODS FOR DETECTING BIOLOGICAL MOLECULES - The present invention relates to a labeling reagent of formula: | 06-03-2010 |
| 20100110430 | DEVICE FOR SORTING AND CONCENTRATING ELECTROMAGNETIC ENERGY AND APPARATUS COMPRISING AT LEAST ONE SUCH DEVICE - A device for sorting and concentrating electromagnetic energy impinging a surface of the device, the surface including at least one plasmonics-based surface structure or similar structure of periodic or quasi-periodic surface topography. The device is characterised in that the surface (V) is provided with at least two such surface structures ( | 05-06-2010 |
