UNIVERSITE DE STRASBOURG Patent applications |
Patent application number | Title | Published |
20160075677 | SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS - Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90. | 03-17-2016 |
20150307589 | PEPTIDIC ANTAGONISTS OF CLASS III SEMAPHORINS/NEUROPILINS COMPLEXES - The present invention concern a peptidic antagonist of class III semaphorins/neuropilins complexes comprising an amino acid sequence, which is derived from the transmembrane domain of a protein selected in the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin Beta 1 and integrin beta 2, and including at least a GxxxG motif, eventually fused to an heterologous sequence; a nucleic acid encoding for said peptidic antagonist, a pharmaceutical composition comprising such a peptidic antagonist or a nucleic acid encoding thereof and uses thereof. | 10-29-2015 |
20150175555 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS - The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications. | 06-25-2015 |
20150072442 | SPIN INJECTOR DEVICE COMPRISING A PROTECTION LAYER AT THE CENTRE THEREOF - A method for manufacturing a spin injector device, comprising the following steps of:
| 03-12-2015 |
20150044717 | DEVICES AND METHODS FOR OBSERVING EUKARYOTIC CELLS WITHOUT CELL WALL - The present invention relates to methods and devices for observing eukaryotic cells devoid of cell wall, in particular for observing the cytokinetic ring, the device comprising a plurality of wells suitable for containing only one single eukaryotic cell and characterized in that the dimensions of the wells constrain the cells into an oblong shape with a long axis parallel to the depth of the wells. | 02-12-2015 |
20150038432 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF RETINAL DEGENERATION - The present invention relates to a pharmaceutical composition comprising an inhibitor of eIF2α, a compound increasing the expression and/or activity of protein BiP and/or an inhibitor of Caspase-12, preferably an inhibitor of eIF2α and a compound increasing the expression and/or activity of protein BiP. The present invention also relates to pharmaceutical compositions and methods for treating retinal degeneration related to ciliary dysfunction. | 02-05-2015 |
20140363886 | METHOD FOR PREPARING INDUCED PARAXIAL MESODERM PROGENITOR (IPAM) CELLS AND THEIR USE - The present invention relates to an ex vivo method for preparing induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signaling pathway and an effective amount of an inhibitor of the Bone Morphogenetic Protein (BMP) signaling pathway. | 12-11-2014 |
20140336368 | MULTIMODAL CONTRAST AND RADIOPHARMACEUTICAL AGENT FOR AN IMAGING AND A TARGETED THERAPY GUIDED BY IMAGING - A multimodal contrast and radiopharmaceutical agent for an imaging and a targeted therapy guided by imaging. | 11-13-2014 |
20140328864 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REDUCING AIRWAY HYPERRESPONSE - The present invention relates to agent selected from the group consisting of an anti-S100B antibody, an anti-S100B aptamer or an inhibitor of S100B gene expression for use in a method for reducing airway hyperresponse in a subject in need thereof. The present invention also relates to a method for determining whether a subject is at risk of having or developing an airway hyperresonse comprising determining the level of S100B protein in a biological sample obtained from said subject. | 11-06-2014 |
20140243391 | PHOSPHOLIPID-DETERGENT CONJUGATES AND USES THEREOF - The invention relates to novel compounds, in particular novel O-substituted phospholipids that are useful for the in vitro and in vivo delivery of drugs as well as nucleic acids into cells. The invention also relates to pharmaceutical compositions and supramolecular complexes comprising said compounds and the use of these compounds in therapeutic treatment, in particular in gene therapy. | 08-28-2014 |
20140234884 | FLUOROGENIC SUBSTRATES, METHODS OF MAKING THE SUBSTRATES, AND METHODS OF DETECTING GLYCOSIDASE ACTIVITIES - Fluorogenic substrates, methods of making the fluorogenic substrates, and methods of detecting glycosidase activities (EC3.2.1) are provided. The fluorogenic substrates are composed of a sugar covalently bonded to the 7-hydroxy position of a substituted coumarin sulfonated fluorophore is provided. The fluorogenic substrates include sodium β-D-cellobioside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium β-D-glucoside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium β-D-xyloside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium β-D-xylobioside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; and sodium β-D-xylopolyoside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate. The fluorogenic substrates may be made by covalently bonding the sugar moiety to the 7-hydroxy position of the substituted coumarin sulfonated fluorophore by reaction in DMF. Glycosidase activities can be detected in enzymatic extracts, microorganisms, and cells by contacting the extracts, microorganisms, or cells with one of the fluorogenic substrates. | 08-21-2014 |
20140221462 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CARDIOMYOPATHY DUE TO FRIEDREICH ATAXIA - A method for preventing or treating cardiomyopathy due to energy failure in a subject in need thereof is provided. The method comprises administering to the subject a therapeutically effective amount of a vector which comprises a nucleic acid sequence encoding a gene that can reverse energy failure. An exemplary cardiomyopathy is that which is associated with Friedreich ataxia and an exemplary nucleic acid sequence comprises a nucleic acid that encodes frataxin (FXN). | 08-07-2014 |
20140200161 | METHOD OF PREPARING AN ADDUCT - A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, the molecular structure(s) each including one nucleotide chain onto which is hybridized at least one PNA-encoded molecule. | 07-17-2014 |
20140199261 | METHOD OF REDUCING MULTI-DRUG RESISTANCE USING INOSITOL TRIPYROPHOSPHATE - Inositol trisphosphate (ITPP) causes normalization of tumor vasculature and is a particularly effective cancer therapy when a second chemotherapeutic agent is administered following partial vascularization. ITPP also treats, alone or in combination, multi-drug resistant cancers. ITPP can also be used to reduce the amount of a second chemotherapeutic drug required for anticancer activity. In addition, ITPP enhances immune response and treats hyperproliferative disorders. | 07-17-2014 |
20140194391 | CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN - The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease. | 07-10-2014 |
20140186872 | BISACODYL AND ITS ANALOGUES AS DRUGS FOR USE IN THE TREATMENT OF CANCER - The present invention provides compounds having the formula A: (A) or pharmaceutically acceptable salt thereof, wherein W, R1, R2 and R5 are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as cytotoxic agents towards proliferating and/or quiescent cancer stem cells, and thus are useful, for example, for the treatment of cancer. | 07-03-2014 |
20140171394 | CYCLITOLS AND THEIR DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS - The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents. | 06-19-2014 |
20140155334 | POLYPHOSPHATE AND PYROPHOSPHATE DERIVATIVE OF SACCHARIDES - The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery. | 06-05-2014 |
20140141442 | LINEAR DNA AMPLIFICATION - The present invention provides materials and methods for DNA amplification, in particular linear amplification methods using RNA polymerase. These methods permit high-throughput sequencing of pictogram amounts of DNA and are of use in a range of applications including genome-wide profiling of transcription factors and epigenetic DNA and histone modifications, global transcript profiling, mapping of chromatin conformations, as well as for forensic use and archaeological studies. | 05-22-2014 |
20140135290 | MACROCYCLIC PRODRUG COMPOUNDS USEFUL AS THERAPEUTICS - The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative disease, cancer, a cardiovascular disease, allergy, asthma, a hormone-related disease, and tumors or symptoms resulting from neurofibromatosis. | 05-15-2014 |
20140127169 | INDUCED PRESOMITIC MESODERM (IPSM) CELLS AND THEIR USE - The invention relates to a method for reprogramming target cells to multipotent progenitor cells capable of differentiating into muscular, skeletal or dermal cell lines. In particular, the invention relates to an ex vivo method for preparing induced presomitic mesoderm (iPSM) cells, said method comprising the steps of: a) providing target cells to be reprogrammed, and, b) culturing said target cells under appropriate conditions for reprogramming said target cells into iPSM cells, wherein said appropriate conditions comprises increasing expression of at least one T-Box transcription factor in said target cells. The invention further relates to the use of said iPSM cells, for example, for regenerating skeletal, muscle, dermal and cartilage tissues. | 05-08-2014 |
20140093884 | Process for Identifying Novel Anti-Inflammatory Molecules with Reduced Direct Transrepression of Genes Induced by Glucocorticoids - The present invention relates to a new process for identifying novel anti-inflammatory molecules with reduced direct transrepression of genes induced by glucocorticoids. | 04-03-2014 |
20140088036 | POLYPHOSPHATE AND PYROPHOSPHATE DERIVATIVE OF SACCHARIDES - The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery. | 03-27-2014 |
20140065067 | RADIOPAQUE IODINATED PRODUCTS INTENDED FOR USE MEDICAL IMAGING AND THEIR METHODS - Iodinated amphiphilic compound of formula (I): | 03-06-2014 |
20140058079 | DERIVATIVES OF ALLOPREGNANOLONE AND OF EPIALLOPREGNANOLONE AND USES THEREOF FOR TREATING A NEUROPATHOLOGICAL CONDITION - The présent invention relates to novel neurosteroids, especially derivatives of allopregnanolone and of epiallopregnanolone of formula (I) and the uses thereof as médicament for the treatment of neuropathologies, in particular neuropathies induced by the chemotherapy of a cancer. Thèse molécules according to the invention have both preventative and curative effects. The neurosteroids according to the invention may also be of use in the treatment of neurodegenerative disorders, in particular for preventing neuronal cell death. They may thus be used as neuroprotectants and/or as an agent that stimulâtes neuronal prolifération. | 02-27-2014 |
20140050773 | COMPOUND COMPRISING ALPHA-MSH FOR USE IN ENDODONTIC REGENERATION - The present invention concerns a compound comprising an α-MSH peptide, coupled to a polypeptide consisting of a chain of about 15 to about 400 amino acids, for use in endodontic regeneration and/or for the treatment of dental inflammatory diseases. The invention further concerns pharmaceutical compositions, in particular nanostructured compositions, comprising such a compound. | 02-20-2014 |
20140045910 | NOVEL AMINO-PYRROLINE DERIVATIVES, AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF METABOLIC SYNDROME - Novel amino-pyrrolinic derivatives, their pharmacologically acceptable salts and use thereof in the prevention and/or treatment of metabolic syndrome. | 02-13-2014 |
20140045173 | COMPOUNDS HAVING CHROMOPHORE AND PHOTOREACTIVE GROUPS - The invention relates to the field of hydrophobic photoaffinity marking by element of probes that are multifunctional lipid compounds. The compounds include at least one chromophore group and two lipid chains, one of which includes a photoreactive group. The compounds can be used for the study and identification of hydrophobic regions or domains within proteins, particularly within viruses. | 02-13-2014 |
20140037651 | DEPLETED ANTI-STAPHYLOCOCCAL ENTEROTOXINS POLYCLONAL ANTIBODIES, PREPARATION AND USES THEREOF - The present invention relates to the preparation of a set of depleted polyclonal antibodies, each depleted polyclonal antibody being raised against one specific staphylococcal enterotoxin, and its use for multiplex detection. | 02-06-2014 |
20140031302 | POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES - The present invention includes novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, pochoximes, and their syntheses. The present invention also provides a pharmaceutical composition comprising the present compound and the use of the compound as inhibitors of kinases and of the enzyme family known as heat shock protein 90 (HSP90). | 01-30-2014 |
20130325144 | NANO-RESERVOIRS TECHNOLOGY FOR USE IN BONE AND/OR CARTILAGE REGENERATION - The present invention concerns a biomaterial comprising a nanofibrous scaffold made of polymers, such as poly(ε-caprolactone) or collagen, coated with at least one layer pair consisting of a layer of polyanions and a layer of polycations, wherein said at least one layer pair incorporates a therapeutic molecule such as a growth factor. The biomaterial may optionally comprise living cells such as osteoblasts and/or chondrocytes. | 12-05-2013 |
20130287738 | DISEASE-ASSOCIATED PROTEIN - Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions. | 10-31-2013 |
20130258431 | INSTRUMENT CLUSTER FOR A MOTOR VEHICLE - An instrument cluster, in particular for a motor vehicle comprises a display screen to display information to the driver of the vehicle, a holographic memory containing the information stored in the form of holograms, and a light source to generate one or more reading light beams to extract the information to be displayed from the holographic memory and display the information extracted from the holographic memory on the display screen. A head-up display device is integrated in the instrument cluster and comprises a combiner that projects information extracted from the holographic memory into the head-up field of view of the driver. | 10-03-2013 |
20130196084 | Process for the Production of a Nanomaterial and Reactor for Implementing it - The present invention relates to a novel process for synthesizing nanomaterials by mixing liquids in a quasi-2D microfluidic reactor. The invention also relates to the reactor for implementing this process. | 08-01-2013 |
20130193426 | USE OF ZWITTERIONIC MOLECULES FOR FORMING A HOLE OR ELECTRON TRANSPORT LAYER - The invention relates to the use of zwitterionic molecules for forming a hole or electron transport layer. The preferred zwitterionic molecules of the invention are derivatives of p-benzoquinonemonoimines. The invention is useful in the field of electronic devices in particular. | 08-01-2013 |
20130190524 | CYCLITOLS AND THEIR DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS - The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents. | 07-25-2013 |
20130183700 | SULFONATED COUMARINS, SYNTHESIS THEREOF, FLUOROGENIC SUBSTRATES RESULTING FROM GRAFTING SAID COUMARINS ONTO SUGARS, METHOD FOR PREPARING SAID SUBSTRATES, AND USES THEREOF - Substituted sulfonated coumarins are expressed in the general formula (I), where: R | 07-18-2013 |
20130157968 | COSMETIC COMPOSITION - The invention relates to novel eucomic acid (2-(4-hydroxybenzyl)malic acid) derivatives or plant extracts comprising such derivatives, and also to cosmetic or dermatological compositions containing these compounds or these extracts, and to cosmetic care methods using said compositions. Exemplary compounds are represented by formula (I) below: | 06-20-2013 |
20130129907 | METHOD FOR PRODUCING THIN LAYERS - The invention relates to a method for providing organic, semi-organic, mineral, inorganic and hybrid thin layers and thin layers containing nanoparticles, by simultaneous or alternate spraying of solutions of reactive partners (that is polymer/polymer interacting by hydrogen bonding, polyelectrolyte/small oligo-ion, inorganic compounds, etc.) on the surface of a solid substrate. | 05-23-2013 |
20130129676 | COMBINATION OF ANTI-ENVELOPE ANTIBODIES AND ANTI-RECEPTOR ANTIBODIES FOR THE TREATMENT AND PREVENTION OF HCV INFECTION - The present invention provides combinations of antibodies for use in the treatment or the prevention of HCV infection. In particular, combinations are provided that comprise at least one anti-HCV envelope antibody and at least one anti-HCV receptor antibody, wherein the anti-HCV-envelope antibody and anti-HCV-receptor antibody act in a highly synergistic manner to inhibit HCV entry into susceptible cells. Also provided are pharmaceutical compositions and kits comprising such combinations and methods of using these compositions and kits for treating or preventing HCV infection. | 05-23-2013 |
20130096177 | POLYMERS FOR DELIVERING MOLECULES OF INTEREST - The present invention relates to a new class of cationic polymers that self-assemble with a pH-sensitive dissolution switch, and their uses to deliver molecules of interest to a cell. The present invention also relates to compositions comprising said cationic polymers non-covalently associated with a molecule of interest, in particular with a siRNA. | 04-18-2013 |
20130076791 | HEAD-UP DISPLAY SYSTEM - Independent optical unit for head-up display system for motor vehicle, intended for the display in the field of view of the driver of a virtual image obtained from an object image coming from a projector, including a first optical component reflecting the incident light rays emanating from the projector towards a second optical component placed in the field of view of the driver for the positioning of a final virtual image, means being provided for the adjustment of their relative position. | 03-28-2013 |
20130072404 | APPARATUS AND PROCESSES FOR GENERATING VARIABLE CONCENTRATION OF SOLUTES IN MICRODROPLETS - The present invention relates to systems and methods for generating microdroplets with varying concentrations of a particular solute from a solution at fixed concentration. | 03-21-2013 |
20130064776 | LABELLED SILICA-BASED NANOMATERIAL WITH ENHANCED PROPERTIES AND USES THEREOF - The present invention relates to labelled silica-based nanoparticles with enhanced properties, to process for preparing them and to uses thereof. | 03-14-2013 |
20130053434 | IRREVERSIBLE INHIBITORS USEFUL FOR THE TREATMENT OF KINASE-RELATED PATHOLOGIES - The present invention provides new compounds having a kinase inhibitory activity and useful for treating cancer. | 02-28-2013 |
20130037307 | Electric Conduction Through Supramolecular Assemblies of Triarylamines - The present invention relates to a method for modifying a surface of a solid conducting material, which comprises a step (E), in which a potential difference is applied between this surface and a surface of another conducting solid material positioned facing it, and wherein, simultaneously, said surface (S) is put into contact with a liquid medium comprising in solution triarylamines (I): | 02-14-2013 |
20130023986 | ARTIFICIAL RETINA THAT INCLUDES A PHOTOVOLTAIC MATERIAL LAYER INCLUDING A TITANIUM DIOXIDE SEMICONDUCTOR - An artificial retina that includes: (i) a substrate; (ii) a first layer, placed onto said substrate and including photovoltaic material portions separated by at least one insulating material portion; and (iii) a second layer, placed onto said first layer and including conductive material portions separated by at least one insulating material portion. In said artificial retina, the photovoltaic material includes a titanium dioxide semiconductor. | 01-24-2013 |
20130017944 | SOLID CATALYTIC COMPOSITIONS BASED ON MESOPOROUS ORGANIC MATERIALSAANM Mesini; PhilippeAACI SandAACO FRAAGP Mesini; Philippe Sand FRAANM Nguyen; Thi Thanh TamAACI LureAACO FRAAGP Nguyen; Thi Thanh Tam Lure FRAANM Simon; Francois-XavierAACI Levallois PerretAACO FRAAGP Simon; Francois-Xavier Levallois Perret FRAANM Khelfallah; Nawel SouadAACI Francfort Sur Le MainAACO DEAAGP Khelfallah; Nawel Souad Francfort Sur Le Main DE - The present invention relates to the preparation of a solid catalytic composition based on a functionalized porous organic material, wherein: (A) organogelator compounds are self-assembled, within a medium comprising organic monomers, in the form of fibrillar structures having a diameter ranging from 10 nm to 100 nm; and then (B) the monomers are then polymerized; and then (C) the organogelator compounds are extracted from the polymer material, thereby obtaining a porous polymer material (M | 01-17-2013 |
20120241690 | PREPARATION OF GRAPHENE BY MECHANICALLY THINNING GRAPHITE MATERIALS - The preparation of graphene, mono-, bi- and multi-layers from graphite-based precursor materials, for example, pencil lead or graphite, by a method of mechanical thinning on the surface of a planar substrate with controlled roughness, followed by sonication in order to collect the graphene deposited on the substrate in a liquid medium. The bearing force during thinning by mechanical friction enables the number of graphene sheets deposited on the surface of the substrate to be controlled. | 09-27-2012 |
20120196865 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway - The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein signaling pathway, as well as to pharmaceutical compositions containing same. The present invention also relates to novel acyl guanidine derivatives as such. | 08-02-2012 |
20120149122 | DEVICE AND METHOD FOR DETERMINING THE CONCENTRATION OF A COMPOUND IN AN AQUEOUS OR GASEOUS PHASE - A device for determining the concentration of a compound in an aqueous phase in a dynamic manner and while flowing, and a device ( | 06-14-2012 |
20120121480 | MICROFLUIDIC DEVICES FOR RELIABLE ON-CHIP INCUBATION OF DROPLETS IN DELAY LINES - The present invention relates generally to droplet creation, fusion and sorting, and incubation for droplet-based microfluidic assays. More particularly, the present invention relates to delay-lines, which allow incubation of reactions for precise time periods. More particularly, the present invention relates to delay lines for incubations up to three hours, while reducing back-pressure and dispersion in the incubation time due to the unequal speeds with which droplets pass through the delay line. | 05-17-2012 |
20120115751 | METHOD OF PREPARING AN ADDUCT - A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, the molecular structure(s) each including one nucleotide chain onto which is hybridized at least one PNA-encoded molecule. | 05-10-2012 |
20120108721 | MICROFLUIDIC SYSTEM AND METHODS FOR HIGHLY SELECTIVE DROPLET FUSION - A method and chip for fusing droplets in a chip comprising (i) providing a first set of droplets which are partially or not stabilized by surfactant, (ii) providing a second set of droplets which are stabilized by surfactant, (iii) contacting each droplet of the first set with single or multiple droplets of the second set in a pairing module and (iv) fusing droplets of the first set with droplets of the second set through a droplet fusion module in which the droplets experience at least one acceleration and/or deceleration and/or reorientation and/or rearrangement in space and time. | 05-03-2012 |
20120101153 | ROCAGLAOL DERIVATIVES AS CARDIOPROTECTANT AGENTS AND AS ANTINEOPLASTIC AGENTS - The present invention discloses new rocaglaol derivatives and the use of rocaglaol derivatives to prevent or to limit the cardiotoxicity of an antineoplastic agent, in particular to prevent or to limit the apoptosis of cardiomyocytes induced by such agent. | 04-26-2012 |
20120082728 | MULTIFUNCTIONAL STEALTH NANOPARTICULES FOR BIOMEDICAL USE - The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and therapeutic properties respectively, as well as an optional fourth type of monomers with targeting properties. The present invention also relates to core-shell or hollow shell nanoparticles coated by an external layer of the copolymer according to the invention. Several types of core-shell nanoparticles are envisaged. The invention also concerns methods for preparing said nanoparticles, as well as pharmaceutical compositions or medicaments comprising them. | 04-05-2012 |
20120079768 | CATALYST FOR REFORMING TAR USED IN THE STEAM GASIFICATION OF BIOMASS - A catalyst includes an olivine substrate on which an iron compound layer is deposited, produced by impregnating the olivine substrate with a solution including an iron salt, and then heat-treating. The catalyst is useful for steam-reforming tar, in particular in gaseous media from the steam gasification of biomass. Further, the catalyst can be used alone for catalyzing the steam gasification of organic compounds from biomass while limiting the amount of tar produced in the synthesized gases. | 04-05-2012 |
20120077775 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 - Disclosed are macrocyclic compounds of formulae I-V, which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90. | 03-29-2012 |
20120035098 | NOVEL ANTIVIRAL AGENT - The present invention describes the use of a composition including or constituted by at least one element chosen from:
| 02-09-2012 |
20110294732 | ERYTHROPOLETIN COMPLEMENTATION OR REPLACEMENT - The present invention provides methods and compositions to replace up to 90% of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P | 12-01-2011 |
20110236347 | Monoclonal Anti-Claudin 1 Antibodies for the Inhibition of Hepatitis C Virus Infection - The present invention provides monoclonal antibodies that specifically bind to the extracellular domain of human Claudin-1 on the cell surface, thereby inhibiting HCV entry into susceptible cells and preventing HCV infection of these cells; and hybridoma cell lines which produce such monoclonal antibodies. Also provided are reagents that comprise such antibodies, and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing HCV infection by administration of an inventive monoclonal antibody, or a pharmaceutical composition thereof are also described. | 09-29-2011 |
20110223242 | NANOPARTICLES CONTAINING A PEPTIDE, VECTORS CONTAINING SAID NANOPARTICLES, AND PHARMACEUTICAL USES OF SAID NANOPARTICLES AND VECTORS - The invention relates to nanoparticles comprising a matrix containing at least one polysaccharide as well as the peptide P140 having the sequence SEQ ID NO: 1 or an analog thereof, said polysaccharide preferably being a polysaccharide bearing one or more negatively-charged functional groups. The invention also relates to a carrier for oral administration that comprises a carrier including at least one nanoparticle as defined above and either containing or not containing a dispersant. | 09-15-2011 |
20110217335 | SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS - Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90. | 09-08-2011 |
20110190237 | Macrocyclic Prodrug Compounds Useful as Therapeutics - The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative disease, cancer, a cardiovascular disease, allergy, asthma, a hormone-related disease, and tumors or symptoms resulting from neurofibromatosis. | 08-04-2011 |
20110189242 | ORAL GALENIC FORM, POLYMER PRODUCTION METHOD AND USE OF SAME - The polymers, according to the invention, comprise a polysaccharide block ( | 08-04-2011 |
20110184390 | DEVICE FOR THE CONTROLLED TRANSLATIONAL DISPLACEMENT OF AN ELONGATE ELEMENT - A device for controlled translational displacement of an elongated element that terminates in a frontal functional end, in particular an instrument or a tool that is designed to be brought to an internal site in a patient, more particularly an exploratory instrument or a surgical tool placed in a catheter or in an operating channel or working channel of a flexible endoscope, whereby the device includes a linear actuator that acts at the rear end of the elongated element that is located opposite its frontal functional end. Device ( | 07-28-2011 |
20110111514 | LABELLING REAGENTS HAVING A PYRIDINE NUCLEUS BEARING A DIAZOMETHYL FUNCTION, PROCESS FOR SYNTHESIS OF SUCH REAGENTS AND PROCESSES FOR DETECTION OF BIOLOGICAL MOLECULES - A process for synthesis of a labelling reagent, a process for the labelling of a biological molecule, a labelled biological molecule obtained by the process, a process for labelling and fragmentation of a single or double strand nucleic acid, a labelled nucleic acid capable of being obtained by the process, a kit for detection of a target nucleic acid containing a labelled nucleic acid, a solid support onto which is attached a reagent and a process for capture of nucleic acids. | 05-12-2011 |
20100311056 | METHOD FOR HYBRIDIZING NUCLEIC ACIDS - The invention relates to a method for manipulating, isolating, detecting or amplifying a target nucleic acid in a sample by hybridization with an oligonucleotide-oligocation conjugate, comprising allowing said nucleic acid to react with an oligonucleotide-oligocation conjugate comprising at least A1 and Bj linked together directly or via a linker, wherein. A, is an i-mer oligonucleotides, with i=3 to 50, where Ai is an oligomer with naturally or non naturally occurring nucleobases and/or pentafuranosyl groups and/or native phosphodiester bonds, optionally comprising a marker group. Bj is a j-mer organic oligocation moiety, with j=1 to 50, where B is —HPO | 12-09-2010 |
20100304378 | Method for Detecting or Quantifying a Truncating Mutation - The present invention discloses a new method for detecting or quantifying a truncating mutation of a target gene in a subject, said method relying on the in vitro compartmentalization of single genetic constructs in aqueous droplets of a water-in-oil emulsion. | 12-02-2010 |
20100267674 | CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN - The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease. | 10-21-2010 |
20100191095 | PROCESS, DEVICE AND SYSTEM FOR REDUCING THE ARTIFACTS THAT AFFECT ELECTROPHYSIOLOGICAL SIGNALS AND THAT ARE DUE TO ELECTROMAGNETIC FIELDS - A method for collecting and a device for sensing at least one electrophysiological signal, as well as to a system including at least one such device. The device for sensing at least one electrophysiological signal from a living subject subjected to at least one electromagnetic field, includes elements, such as electrodes, which are placed on the subject for the physical acquisition of at least one electrophysiological signal and at least elements for the pre-processing of the at least one sampled electrophysiological signal. The sensor device ( | 07-29-2010 |
20100168518 | FLEXIBLE ENDOSCOPE DEVICE WITH VISUAL CONTROL AND PROCESS FOR STABILIZATION OF SUCH A DEVICE - A flexible endoscope device includes an elongated flexible body having an end segment bearing or defining the endoscope head, and provided with an optical system that can be curved or bent in at least two mutually perpendicular directions, the elongated body being functionally connected at the other end thereof to a control element capable of controlling at least the movements and/or the arrangement of the end segment. The device includes automatic flexion and positioning elements of the end segment by visual control, the elements essentially including a video processing element for receiving the images or video signals provided by the optical system of the endoscope head using a computer element capable of carrying out visual control operations on the basis of the processed video signals and of transmitting control signals, and actuation members that are part of or associated with the control elements. | 07-01-2010 |
20100167957 | METHODS FOR PRODUCING ACTIVE SCFV ANTIBODIES AND LIBRARIES THEREFOR - The present disclosure describes scFv antibody libraries, antibodies isolated from the libraries, and methods of producing and using the same. | 07-01-2010 |
20100136538 | MARKING REAGENTS BEARING DIAZO AND NITRO FUNCTIONS, METHODS FOR THE SYNTHESIS OF SUCH REAGENTS AND METHODS FOR DETECTING BIOLOGICAL MOLECULES - The present invention relates to a labeling reagent of formula: | 06-03-2010 |
20100110430 | DEVICE FOR SORTING AND CONCENTRATING ELECTROMAGNETIC ENERGY AND APPARATUS COMPRISING AT LEAST ONE SUCH DEVICE - A device for sorting and concentrating electromagnetic energy impinging a surface of the device, the surface including at least one plasmonics-based surface structure or similar structure of periodic or quasi-periodic surface topography. The device is characterised in that the surface (V) is provided with at least two such surface structures ( | 05-06-2010 |