Universite de Geneve Patent applications |
Patent application number | Title | Published |
20160067212 | USE OF INSULIN SIGNALING ANTAGONISTS, OPTIONALLY IN COMBINATION OF TRANSFECTION OF NON-BETA CELLS, FOR INDUCING INSULIN PRODUCTION - The invention relates to methods of inducing insulin production in non-beta-cells or converting non-beta-cells into insulin producing cells, as well as methods of preventing and/or treating diabetes and methods of predicting the susceptibility of a diabetic subject to a treatment. | 03-10-2016 |
20160001075 | DEVICE AND METHOD FOR ELECTRICAL STIMULATION OF NEURAL OR MUSCULAR TISSUE - A device for electrical stimulation of neural and/or muscular tissue. The device includes a cochlear implant being equipped with a power source, a speech processor, a microphone adapted to deliver sound signals to said speech processor, a current stimulator, at least an array of electrodes attached to the stimulator, and at least a signal sensor other than the microphone. The device further includes a signal transformation unit, said signal sensors being adapted to capture relevant input information and to deliver a corresponding input signal to the transformation unit, the latter allowing to transform said input signal received from the signal sensors into a modulated electrical output signal adapted to be treated by the speech processor of the cochlear implant. | 01-07-2016 |
20150239938 | Cell Penetrating Peptides - The present invention relates to a short cell penetrating peptide derived from ZEBRA, optionally linked to a cargo molecule. It also relates to a complex comprising said cell penetrating peptide and a cargo molecule, as well as cells loaded with said complex and the use thereof in therapy and diagnosis. | 08-27-2015 |
20150177183 | REVERSIBLE DETECTION OF IONS WITH PERMSELECTIVE MEMBRANES - The present invention relates to an electrochemical method using a permselective membrane for detection of ions in a sample. The permselective electrode includes a lipophilic reagent such as a neutral ionophore or an ion exchanger and a lipophilic ion, the lipophilic reagent being in molar excess relative to the lipophilic ion. The present invention further relates to electrode and electrochemical cell apparatus containing said permselective membrane. The permselective electrode can be used for dynamic electrochemical measurements such as chronopotentiometry. | 06-25-2015 |
20150176006 | NUCLEIC ACIDS FOR DOWN-REGULATION OF GENE EXPRESSION - Recombinant nucleic acid molecules are provided that form hair pin structures and can be used to down-regulate gene expression. For example, a nucleic acid molecule can comprise a flanking and lower stem loop sequence from a mir-16 gene; an antisense target sequence; a mir-30 loop sequence; a complement of the anti-sense target sequence; and a lower stem loop complementary to the mir-16 sequence. Methods for down regulating gene expression in a cell using such recombinant nucleic acid molecules are also provided. | 06-25-2015 |
20140163217 | PROCESS FOR THE ESTERIFICATION OF HYALURONIC ACID WITH HYDROPHOBIC ORGANIC COMPOUNDS - The invention relates to a process for providing esters of hyaluronic acid, hyaluronic acid salts or hyaluronic acid derivatives with hydrophobic organic compounds. The process includes the steps of (i) micronizing the hyaluronic acid, salt or derivative thereof at reduced temperature, (ii) reacting the hydrophobic compound with a micronized hyaluronic acid obtained in (i) in a suitable solvent; and (iii) filtrating or dialyzing reaction mixture obtained in (ii) to obtain the desired ester. Also encompassed by the present invention are the esters obtained by such a method and compositions containing them as well as the use thereof for treating and/or preventing cartilage damage and inflammation. | 06-12-2014 |
20140147440 | USES OF NANOG INHIBITORS AND RELATED METHODS - The present invention relates to substances and compositions thereof useful in the control of cancer stem cell persistence and concomitant tumor recurrence and/or control of tumor growth. In particular, the invention relates to substances and compositions useful in the treatment of cancers and/or tumors linked to cancer stem cells, preferably brain cancers and/or tumors, in a subject. | 05-29-2014 |
20140114232 | APPARATUS FOR THE TREATMENT AND/OR PREVENTION OF CORNEAL DISEASES - An apparatus for the treatment and/or prevention of corneal diseases includes an applicator head. The applicator head includes a radiation source capable of exciting a non-toxic chromophore. A control is operable to activate the radiation source to radiate, wherein at least one of the following two conditions is met: the applicator head includes a sensor capable of measuring a signal dependent on a position of the applicator head relative to the cornea; or, the applicator head is configured to be in physical contact with the cornea. The control is operable to activate the radiation source to radiate depending on a signal measured by the sensor or to activate the radiation source when the applicator head touches the cornea, respectively. | 04-24-2014 |
20140080779 | MACROCYCLIC LACTONES AND USE THEREOF - The present invention is directed to the use of macrocyclic lactones, in particular avermectins, in the treatment of conditions whose formation, occurrence, development or growth is associated with aberrant Wnt signalling in particular the treatment of colorectal cancer. | 03-20-2014 |
20140046195 | IN VIVO BIOLUMINESCENCE MONITORING APPARATUS - Apparatus for real-time in vivo bioluminescence monitoring in a conscious small animal, comprising a light-tight enclosure ( | 02-13-2014 |
20130252834 | Diagnostic Methods - The invention relates to a method of aiding the diagnosis of acute brain damage in a subject, said method comprising (i) assaying the concentration of at least one oxidative stress polypeptide selected from the group consisting of: PRDX1, PRDX6 and GSTP1 in a sample from said subject; and (ii) assaying the concentration of at least one further polypeptide selected from Panel A; (Hi) comparing the concentrations of (i) and (ii) to the concentrations of the polypeptides in a reference standard and determining quantitative ratios for said polypeptides; (iv) wherein a finding of a quantitative ratio of each of the assayed polypeptides in the sample to the polypeptides in the reference standard of greater than 1.3 indicates an increased likelihood of acute brain damage having occurred in said subject. | 09-26-2013 |
20130149711 | BARD1 Isoforms in Lung and Colorectal Cancer and Use Thereof - The present invention relates to new BARD1 isoforms specific to lung cancer and colorectal cancer, a method for detecting thereof and a method for treating and/or preventing lung cancer and colorectal cancer. | 06-13-2013 |
20130136737 | Uses of NOGO-A Inhibitors and Related Methods - The present invention is directed to Nogo-A antagonists useful for the control of blood glucose or blood insulin levels in a subject and related use and formulation thereof. In particular, the invention is directed to Nogo-A antagonists useful for the prevention, repression or treatment insulin secretion deficiency and related methods and pharmaceutical formulations. In particular, the invention relates to Nogo-A antagonists useful in the treatment of diabetes mellitus. | 05-30-2013 |
20130131190 | COMPOSITIONS COMPRISING POLYMERS PREPARED FROM 2-HYDROXYALKYL ACIDS - Described herein are compositions comprising polymers prepared by melt polycondensation of 2-hydroxyalkyl acids. Methods of making and using the compositions are also disclosed. | 05-23-2013 |
20130085100 | New Uses of Oxytocin-Like Molecules and Related Methods - The present invention is directed to a derivative selected from oxytocin, an oxytocin derivative, and an oxytocin agonist useful for the treatment of a disorder selected from obesity and insulin resistance and related methods and pharmaceutical formulations. In particular, the invention relates to a derivative selected from oxytocin, an oxytocin derivative, and an oxytocin agonist useful in the treatment of metabolic syndrome. | 04-04-2013 |
20130028920 | STABILIZED ANTIBODY PREPARATIONS AND USES THEREOF - The present invention is directed to stabilized intact antibody formulations, related methods and uses thereof. In particular, the invention relates to a method of stabilizing an intact antibody in a liquid carrier. | 01-31-2013 |
20130017197 | STABILIZED ANTIBODY PREPARATIONS AND USES THEREOF - The present invention is directed to stabilized intact antibody formulations, related methods and uses thereof. In particular, the invention relates to a method of stabilizing an intact antibody in a liquid carrier. | 01-17-2013 |
20130016835 | APPARATUS AND METHOD FOR DISTRIBUTING A STRING OF SECRET BITS OVER A QUANTUM CHANNELAANM ZBINDEN; HugoAACI GeneveAACO CHAAGP ZBINDEN; Hugo Geneve CHAANM WALENTA; NinoAACI GeneveAACO CHAAGP WALENTA; Nino Geneve CHAANM LIM; Charles Ci WenAACI GeneveAACO CHAAGP LIM; Charles Ci Wen Geneve CH - For distributing a sequence of symbols, an emitter station transmits to a receiver station quantum systems through a quantum channel. Each of the quantum systems belongs to a set of at least two non-orthogonal quantum states and comprises a group of at least two weak coherent states of an electromagnetic field. Each weak coherent state is in a time bin of duration t. Centers of neighboring weak coherent states in a group are separated by a time T | 01-17-2013 |
20120231030 | MULTI-EPITOPIC VACCINE - The present invention relates to isolated polypeptides comprising: (i) a protein transduction domain consisting of ZEBRA or a fragment thereof that retains the capacity of internalization, (ii) at least one CD4 | 09-13-2012 |
20120219538 | STABILIZED PROTEIN FORMULATIONS AND USE THEREOF - The present invention is directed to stable protein formulations, related methods and uses thereof. In particular, the invention relates to a method of stabilizing therapeutic proteins in aqueous solution. | 08-30-2012 |
20120071465 | MITOCHONDRIAL ACTIVITY INHIBITORS OF CANCER-INITIATING CELLS AND USE THEREOF - The present invention relates to the compounds useful in the prevention and/or treatment of tumours. More specifically the present invention relates to inhibitors of the activity of the electron transport chains and/or the mitochondrial TCA cycle in glioma-initiating cells (GICs) for use in a method for preventing and/or treating tumours presenting glioma-initiating cells (GICs) in a subject who has undergone a prior removal of a tumour glioma bulk. The present invention further provides a pharmaceutical composition containing the inhibitors of the invention and a screening method for identifying the inhibitors of the invention. | 03-22-2012 |
20110281862 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL - The present invention relates to compounds of formula (I) | 11-17-2011 |
20110136160 | ANALYSIS OF GLYCATED PROTEINS - This invention relates to a method for analysis of one or more glycated proteins in a sample, the glycated proteins containing moieties of a natural reducing carbohydrate bound at one or more glycation sites in the proteins, the method comprising: treating the sample with a stable isotopic form of said carbohydrate which is different in mass from the natural carbohydrate, whereby the isotopic form becomes incorporated by glycation in one or more proteins in the sample, and one or more of said proteins are accordingly glycated by the natural reducing carbohydrate and by the isotopic form of the carbohydrate at identical glycation sites; and identifying and/or quantifying the glycated proteins by the difference in mass between the natural carbohydrate and the isotopic form of the carbohydrate at identical glycation sites. | 06-09-2011 |
20110112110 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF - Inhibitors of the oncogenic tyrosine kinase ALK and of the Bcr-Abl mutant T315I Bcr-Abl, pharmaceutical compositions containing the same and their use for the treatment of hyper-proliferative diseases. | 05-12-2011 |
20110096955 | SECURE ITEM IDENTIFICATION AND AUTHENTICATION SYSTEM AND METHOD BASED ON UNCLONABLE FEATURES - The present invention is a method and apparatus for protection of various items against counterfeiting using physical unclonable features of item microstructure images. The protection is based on the proposed identification and authentication protocols coupled with portable devices. In both cases a special transform is applied to data that provides a unique representation in the secure key-dependent domain of reduced dimensionality that also simultaneously resolves performance-security-complexity and memory storage requirement trade-offs. The enrolled database needed for the identification can be stored in the public domain without any risk to be used by the counterfeiters. Additionally, it can be easily transportable to various portable devices due to its small size. Notably, the proposed transformations are chosen in such a way to guarantee the best possible performance in terms of identification accuracy with respect to the identification in the raw data domain. The authentication protocol is based on the proposed transform jointly with the distributed source coding. Finally, the extensions of the described techniques to the protection of artworks and secure key exchange and extraction are disclosed in the invention. | 04-28-2011 |
20100316638 | Antibody Formulations and Use Thereof - The present invention is directed to combination formulations of monoclonal antibodies with anti-inflammatory agents, related methods and uses thereof. | 12-16-2010 |
20100248291 | METHODS FOR IDENTIFYING, PURIFYING AND ENRICHING IMMATURE OR STEM CANCER-INITIATING CELLS FROM TUMORS AND USE THEREOF - The present invention is related to methods for the preparation of cell compositions, isolated compositions obtainable therefrom, related isolated cell compositions, kits and use thereof. More specifically, the present invention provides a method for identifying, purifying and enriching immature or stem cancer-initiating cells in a 5 sample. The cell compositions, related methods and uses according to the present invention are useful in the treatment of cancers and/or the detection of enriching immature or stem cancer-initiating cells, notably cancers of the central and peripheral nervous system, metastasis to the brain. | 09-30-2010 |
20100028406 | TOPICAL DRUG DELIVERY BY IONTOPHORESIS - The invention generally concerns methods of topical drag delivery. Delivery according to the invention may be via electrotransport of compounds through the skin, for example by iontophoresis. In certain embodiments improved methods for the delivery of compounds, such as antimicrobial agents are described. | 02-04-2010 |
20090209508 | Compounds for Photochemotherapy - Enzyme-activatable photosensitizing polymer conjugates are disclosed for photochemotherapeutic treatment of human diseases and disorders, bacteriologic or virologic indications, cosmetic applications and other pathologic situations. These polymer conjugates may comprise a polymer carrier, a photosensitizer, a quencher, a targeting molecule and/or a biocompatibilizing unit. These macromolecular conjugates may be designed to guide to the target tissue a photosensitizing agent in an inactive, non-phototoxic form. However, upon entering the target environment, in which certain enzymes are presently active, the conjugate may release its photosensitizers in its fully active form, resulting in a highly localized activation of the photoactive agent. Also described here are methods, compositions and kits for the preparation and testing of such photochemotherapcutic conjugates. | 08-20-2009 |
20090081122 | Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant - The injectable formulation for treatment by hyperthermia comprises a liquid carrier and heat-generating superparamagnetic iron oxide nanoparticles having a mean diameter not greater than 20 nm. Said injectable formulation is able to form in-situ a hyperthermic solid or semi-solid implant upon contact with a body fluid or tissue. Said hyperthermic solid or semi-solid implant may be useful for treating a tumor or a degenerative disc disease by hyperthermia. | 03-26-2009 |