| UNIVERSITE D'ANGERS Patent applications |
| Patent application number | Title | Published |
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| 20120027825 | METHOD OF PREPARING LIPID NANOPARTICLES - The present invention relates to a useful method for preparing nanocapsules having a liquid lipid core and a solid shell and charged with at least one active agent having a hydrophilic character, said method comprising at least the steps consisting in: i) providing at least a first microemulsion having a water-in-oil character, stabilized by at least one lipophilic surfactant and containing in its hydrophilic phase at least one active agent having a hydrophilic character, providing at least a second microemulsion, separate from the first microemulsion, formulated by phase inversion of an emulsion and stabilized by at least one heat-sensitive, nonionic hydrophilic surfactant; iii) adding said first microemulsion to said second microemulsion under conditions propitious for the formation of a novel microemulsion architecture in which said hydrophilic active agent remains present in the hydrophilic phase of the first microemulsion; and iv) chill-hardening the mixture formed in the previous step, so as to obtain nanocapsules comprising said hydrophilic active agent and being formed from a lipid core, which is liquid at room temperature, and encapsulated in a film which is solid at room temperature. | 02-02-2012 |
| 20120020442 | METHOD AND AN APPARATUS FOR DECONVOLUTING A NOISY MEASURED SIGNAL OBTAINED FROM A SENSOR DEVICE - The present invention relates to a method and apparatus for deconvolving a noisy measured signal obtained from a sensor device ( | 01-26-2012 |
| 20120010824 | Non-Invasive Method for Assessing Liver Fibrosis Progression - The present invention relates to a non-invasive method for assessing liver fibrosis progression in an individual, said method comprising the steps of calculating the ratio of fibrosis level to cause duration and to a non-invasive method for assessing liver fibrosis progression in an individual, said method comprising the steps of measuring, at two different times t | 01-12-2012 |
| 20110318760 | METHOD FOR THE IN VITRO DIAGNOSIS OF AN AUTOIMMUNE RESPONSE ASSOCIATED WITH THE EXISTENCE OF AN ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES-ASSOCIATED VASCULITIS BY DETECTION OF ANTIBODIES DIRECTED AGAINST THE PENTRAXIN 3 ANTIGEN - A method for the in vitro diagnosis of an autoimmune immune response in an individual by detection, in a biological fluid from said individual, of antibodies directed against the pentraxin 3 (PTX3) antigen, characterized in that the presence of antibodies directed against the PTX3 antigen (anti-PTX3 antibodies) are determined in a biological fluid from the individual, and kits for implementing the method. | 12-29-2011 |
| 20110313276 | NON-INVASIVE IN VITRO METHOD FOR QUANTIFYING LIVER LESIONS - An in-vitro non-invasive method for quantifying the lesions of the liver of the patient with metabolic steatosis addressing a diagnostic target, i.e. fibrosis, steatosis and/or steato-hepatitis (NASH) and measuring at least one marker selected from the group consisting of biomarkers and possibly clinical markers and possibly scores, the biomarkers being selected from the group consisting of glycemia, AST (aspartate aminotransferase), ALT (alanine aminotransferase), AST/ALT, AST.ALT, ferritin, platelets, prothrombin index, hyaluronic acid, haemoglobin, triglycerides; the biomarker selected from weight, body mass index, sex and age, hip perimeter, abdominal perimeter and ratio thereof; the scores being selected from score of fibrosis, area of fibrosis, fractal dimension of fibrosis, score of steatosis, area of steatosis, fractal dimension of steatosis and combining the measures in a mathematical function combining the measures through a binary (or ordinal) logistic function or multiple linear regression including the markers in order to obtain an end value. | 12-22-2011 |
| 20110306849 | Diagnosis of Liver Fibrosis and Cirrhosis - This invention relates to method of diagnosing the presence and/or severity of a liver pathology and/or of monitoring the effectiveness of a curative treatment against a liver pathology in an individual, leading to a score, comprising the combination, of at least one blood test and of at least one data issued from a physical method of diagnosing liver fibrosis, said data being selected from the group consisting of medical imaging data and clinical measurements, said combination being performed through a mathematical function. This invention also relates to a method wherein the combination through a mathematical function, of at least one blood test and of at least one data issued from a physical method of diagnosing liver fibrosis, is performed at least twice and the at least two resulting scores are combined in an algorithm based on the diagnostic reliable intervals. | 12-15-2011 |
| 20110246079 | INDIVIDUAL 5-FLUOROURACILE DOSE OPTIMIZATION IN FOLFOX TREATMENT - The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5-FU dose administered by continuous infusion in patients treated by a FOLFOX regimen or a similar regimen, based on the 5-FU plasmatic concentration measured during the previous 5-FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5-FU dose administered in continuous infusion in each FOLFOX or similar treatment cycle is optimized using the decision algorithm according to the invention. | 10-06-2011 |
| 20100310669 | Dispersion of Poloxamer- Protein Particles, Methods of Manufacturing and Uses Thereof - The present invention relates to a method for preparing poloxamer-protein particles. It also relates to poloxamer-protein particles obtainable by this method, dispersion thereof, and their use in methods of encapsulation, in particular of microencapsulation. | 12-09-2010 |
| 20100131286 | METHODS FOR THE PROGNOSIS OR FOR THE DIAGNOSIS OF A THYROID DISEASE - The present invention relates to methods for predicting or diagnosing a thyroid disease in an individual. | 05-27-2010 |
| 20090300776 | COMPOSITIONS FOR PREVENTING, REDUCING OR TREATING KERATINOCYTE-MEDIATED INFLAMMATION - The present invention relates to the field of epidermal repair. More particularly, the invention concerns the use of a molecule able to inhibit a heteromeric receptor comprising OSMRβ as a subunit, for the preparation of a composition for inhibiting the expression of inflammatory factors by the keratinocytes. In particular, the invention concerns the use of antagonists and/or expression inhibitors of OSM, IL-17, TNFα, IL-31, IFN-γ, and/or the OSMRβ subunit, for the preparation of cosmetic or dermatologic compositions, especially for treating inflammatory skin diseases. | 12-03-2009 |
| 20090238865 | LIPID NANOCAPSULES, PREPARATION PROCESS AND USE AS MEDICINE - The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially lipid film solid at room temperature having a thickness of 2-10 nm. The invention also concerns a method for preparing same which consists in producing a reverse phase of an aqueous emulsion brought about by several temperature raising and lowering cycles. Said lipid nanocapsules are particularly designed for producing a medicine. | 09-24-2009 |
| 20090221476 | Peptide Capable of Altering Tubulin Polymerization and use Thereof for Inhibiting Cell Proliferation - The invention concerns a peptide derived from intermediate filaments and an intermediate filament fragment capable of altering tubulin polymerization and used for inhibiting cell proliferation, and more particularly for obtaining medicines designed to prevent or treat diseases involving cell proliferation, such as cancers for example. | 09-03-2009 |
| 20080220037 | Biphosphonic Compounds For Preventing Or Limiting Fixing Of Macromolecules, Microorganisms And Biofilm On Solid, In Particular Metal Or Mineral Surfaces - The invention concerns biphosphonic compounds of formula (I); microbiological anti-contamination compositions containing same, and their use for preventing or limiting fixing of macromolecules, micro-organisms and biofilm on solid surfaces, such as metal or mineral surfaces. | 09-11-2008 |
