UNIVERSITE CLAUDE BERNARD LYON 1 Patent applications |
Patent application number | Title | Published |
20160016153 | GAS-PHASE AND LIQUID-GAS-PHASE NITRILATION PROCESS - A process for the nitrilation of a fatty acid or of a fatty acid ester, which is optionally unsaturated, by reacting the fatty acid or fatty acid ester with ammonia in a reactor operating continuously in the gas phase or in the mixed gas-liquid phase in a temperature range of from 180 to 400° C., in the presence of a solid catalyst comprising at least one metal oxide, the metal of which belongs to column 8 of the periodic table, as a mixture with at least one metal oxide chosen from aluminum oxides, zirconium oxides, niobium oxides, tantalum oxides and tin oxides, the metal oxide(s), the metal of which belongs to column 8, being present in a volume ratio of 0.1 to 0.6 relative to the volume of the mixture of all the oxides. | 01-21-2016 |
20150380771 | METHOD FOR SYNTHESIZING IONIC LIQUIDS HAVING A CARBONATE FUNCTIONAL GROUP AND IONIC LIQUIDS THUS OBTAINED - The present invention relates to a method for synthesizing ionic liquids comprising a carbonate functional group characterized in that it comprises a step of reaction A without addition of lithium between a first reactant selected among an imidazolium, a pyrrolidinium or an ammonium and a second reactant being a methyl formate imidazolium. The first reactant is an imidazolium alcohol, a pyrrolidinium alcohol or an ammonium alcohol salt, the anion of which is NTf2. The second reactant is a chloromethyl formate imidazolium. | 12-31-2015 |
20150349084 | METHOD OF PRODUCING A JUNCTION FIELD-EFFECT TRANSISTOR (JFET) - The invention concerns a method for producing a field effect transistor having a trench gate comprising:—the forming ( | 12-03-2015 |
20150322095 | HYDROSILYLATION METHOD - A method (P) for hydrosilylating at least one compound (C), including at least one unsaturation in the presence of an organosilicon compound (O) including at least one hydrogen atom per molecule bonded directly to a silicon atom, and of a catalytic hydrosilylation system including a structured porous material (A) including pores and an inorganic structure consisting of silicon oxide walls, in which metal nanoparticles are contained. | 11-12-2015 |
20150307622 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF BONE METASTASES - The present disclosure relates to methods and pharmaceutical compositions for the treatment of bone metastases. In particular, the present disclosure relates to an agent selected from the group consisting of an anti-ROB04 antibody, an anti-ROB04 aptamer, a ROB04 decoy polypeptide, an inhibitor of ROB04 expression for use in a method for preventing or treating bone meta-stases in a subject in need thereof. | 10-29-2015 |
20150250770 | LKB1 AS PREDICTIVE MARKER OF EVEROLIMUS EFFICACY IN BREAST CANCER - Method for identifying a breast cancer likely to respond to treatment with everolimus comprising the following steps: Measuring the level of expression of the LKB 1 gene in a breast tumour sample previously taken from a breast cancer patient, Classifying the breast cancer as likely to respond to treatment with everolimus if the LKB1 gene is under-expressed in said breast tumour sample. | 09-10-2015 |
20150158964 | THIOL COMPOUNDS AND THE USE THEREOF FOR THE SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES - The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface. | 06-11-2015 |
20150126731 | Method for the Isomerisation of Glucose into Fructose - The invention relates to a method for the isomerisation of glucose into fructose in water in the presence of a solid base catalyst characterised by its reversibility of CO | 05-07-2015 |
20140329261 | TREATMENT OF CANCER BY INHIBITION OF THE MYD88/ERK MAP KINASE INTERACTION - A method for selecting in vitro compounds is capable of potentiating the effect of a DNA damage inducing chemotherapy agent for the treatment of cancer, and includes selecting compounds inhibiting the interaction between MyD88 and ERK MAP KINASE. | 11-06-2014 |
20140309440 | Method for Preparing Furfural - The invention relates to a method for preparing furfural by reacting pentose in water and in the presence of carboxylic acid and of a heterogeneous acid catalyst, the method being conducted in an aqueous solution of carboxylic acid as a reaction medium. The present invention also relates to the preparation of furfural by reaction of pentose in water and in the presence of carboxylic acid and of a heterogeneous acid catalyst. The invention also relates to an aqueous solution of carboxylic acid rich in furfural. | 10-16-2014 |
20140186364 | INHIBITION OF THE NT-3:TRKC BOUND AND ITS APPLICATION TO THE TREATMENT OF CANCER SUCH AS NEUROBLASTOMA - The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (NT-3 or NT3), to the extracellular domain or TrkC receptor and/or to inhibit the dimerization of the intracellular domain of the TrkC receptor expressed in tumor cells, particularly in neuroblastoma. The disclosure also relates to a method for predicting the presence of metastatic cancer or a bad prognosis cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of neurotrophin 3. The disclosure further comprises kits and compounds as a medicament for the treatment of neuroblastoma or cancer overexpressing neurotrophin 3 by the tumor cells. | 07-03-2014 |
20140121389 | Method for Producing 5-Hydroxymethylfurfural - The invention relates to a method for preparing 5-hydroxymethylfurfural (HMF) by reacting hexose in water and in the presence of carboxylic acid. The present invention further relates to the preparation of 5-hydroxymethylfurfural (HMF) by reacting hexose in water and in the presence of carboxylic acid and of a heterogenous acid catalyst. The invention also relates to an HMF-rich carboxylic acid solution. | 05-01-2014 |
20140086923 | Antibodies Directed Against ICOS and Uses Thereof - The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg. | 03-27-2014 |
20140038883 | NOVEL AZACOUMARIN DERIVATIVES HAVING MDR PUMP INHIBITING ACTIVITY - The present invention relates to compounds of formula (I), where R | 02-06-2014 |
20140030224 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING INFLUENZA VIRUSES REPLICATION - The present invention relates to methods and pharmaceutical compositions for inhibiting influenza virus replication. More particularly, the present invention relates to a compound selected from the group consisting of Gemcitabine, Obatoclax Mesylate, Docetaxel, HA-14, Alsterpaullone, GSK3B inhibitor VIII, GSK3B inhibitor XV, Indirubin 3′- monoxime, L glutathione reduced, Fluocinolone acetonide, Tirofiban, Topotecan hydrochloride, Clofarabine, Vinblastine, Menadione Crystalline and derivatives or analogues thereof for use in the treatment of an influenza infection in a subject in need thereof. | 01-30-2014 |
20140024101 | METHOD FOR INCREASING THE REPLICATION CAPACITY OF AN INFLUENZA VIRUS IN CULTURED CELLS - The present invention relates to methods for increasing the replication capacity of an influenza virus in cultured cells. More particularly, the present invention relates to a method for increasing the replication capacity of an influenza virus in a cell comprising the steps consisting of i) infecting said cell with said influenza virus and ii) culturing said infected cell with a least one molecule selected from the group consisting of Dibucaine, Aprindine, Amiloride, Mevinolin, Simvastatin, Promathazine, Pranlukast, Nimodipine, Ibutilide hemifumarate Salt, Risperidone and derivatives or analogues thereof. | 01-23-2014 |
20130345441 | METHOD FOR PREPARING ALCOHOL CARBONATE USING RARE EARTH OXIDES AS CATALYSTS - Disclosed is a method for preparing, by transcarbonation, a compound of formula (I), including reacting a polyol of formula (II) with an alkyl carbonate or an alkylene carbonate in the presence of a catalytic system consisting of a catalytic entity selected from among the rare earth oxides or the mixtures thereof, and optionally an inert substrate. | 12-26-2013 |
20130316359 | METHOD FOR DETERMINING CANCER PROGNOSIS - The present invention concerns an in vitro method for determining cancer prognosis for a patient suffering from early-stage or low-grade cancer, said method comprising measuring the expression level of ERRα in a biological sample comprising cancer cells. The invention further pertains to an in vitro method for determining bone metastases prognosis for a patient suffering from bone metastases comprising measuring the expression level of ERRα. Finally, the invention pertains to in vitro methods for selecting a patient suffering from cancer, and/or from cancer-derived metastasis, suitable to be treated with a preventive/aggressive therapy. | 11-28-2013 |
20130286897 | SYSTEM AND METHOD FOR DISCOVERING SURROUNDINGS FOR COMMUNICATING OBJECTS - The invention relates to a system for determining surroundings in a wireless network, the system including first and second nodes, each node being programmed to periodically detect the nodes located in the surroundings thereof every time period Δ, characterized in that: the first node comprises a transmitter ( | 10-31-2013 |
20130270596 | LIGHT SENSORS AND SOURCES COMPRISING AT LEAST ONE MICROCAVITY WITH A LOCALIZED TAMM PLASMON MODE - A light source or sensor including: a stack of dielectric or semiconductive layers includes an alternation in a vertical direction of layers of high refractive index and of low refractive index forming an interference mirror, and presenting a top layer of high refractive index; at least one first metal pellet deposited or transferred on the top layer of the stack of layers to form a structure supporting a first Tamm plasmon mode that is spatially localized in at least one lateral direction perpendicular to the vertical direction; and at least one light emitter or detector arranged inside the stack of layers under the metal pellet and at a depth corresponding to a local maximum of the electric field of the Tamm plasmon mode to emit or detect radiation at the resonant wavelength thereof. | 10-17-2013 |
20130216592 | PARTICLES CONSISTING OF A CHITOSAN POLYELECTROLYTE COMPLEX AND OF AN ANIONIC POLYSACCHARIDE, AND HAVING IMPROVED STABILITY - The present invention relates to positively charged particles consisting of a chitosan polyelectrolyte complex and of an anionic polymer, characterized in that the chitosan has a degree of acetylation (DA) in the range of 35 to 49% and a mean molar mass by weight (Mw) in the range of 55 to 150 kg/mol, as well as to a method for preparing same. | 08-22-2013 |
20130142702 | ELECTROCHEMICAL CATALYSIS SYSTEM - The present invention relates to an electrocatalytic system for the joint treatment of oxidizing polluting entities of the NO | 06-06-2013 |
20130136676 | ELECTROCHEMICAL CATALYSIS SYSTEM - The present invention relates to the use, for the reduction of oxidizing contaminating entities of the NO | 05-30-2013 |
20130115242 | Modified Viral Strains and Method for Improving the Production of Vaccine Seeds of Influenza Virus - Modified influenza A/PR/8/34 virus and reassortant influenza A/PR/8/34 virus including a modified PB1 gene and methods for improving the production of HA (hemagglutinin) and NA (neuraminidase) vaccine glycoproteins. | 05-09-2013 |
20130084564 | ASSESSMENT OF CANCER RISK BASED ON RNU2 CNV AND INTERPLAY BETWEEN RNU2 CNV AND BRCA1 - Polynucleotides useful for detecting copy number variation of RNU2 sequences and methods of assessing risk of developing breast or ovarian cancer using molecular combing and/or detection or quantification of BRCA1 expression. | 04-04-2013 |
20130041200 | METHOD OF TREATING EFFLUENTS CONTAINING HALOGENATED COMPOUNDS - The present invention relates to the use of catalysts of general formula (I): | 02-14-2013 |
20130012502 | Pharmaceutical or Veterinary Antiviral Compositions - Pharmaceutical or veterinary compositions to prevent or treat viral infections, in particular to prevent or treat influenza A, B and C virus infections. | 01-10-2013 |
20120309811 | P-GLYCOPROTEIN-SPECIFIC NON-COMPETITIVE PEPTIDE AND PEPTIDOMIMETIC MODULATORS - The invention relates to a compound having structure (I), which acts as a non-competitive specific inhibitor of P-glycoprotein (P-gp for “Pleiotropic glycoprotein”) and which can be used as a drug, particularly for improving the effectiveness of chemotherapy treatments. The invention is therefore suitable for use in the medical field, particularly for the chemotherapeutic treatment of cancers or infections. | 12-06-2012 |
20120295110 | COMPOSITION FOR THE SYNTHESIS OF BIMETALLIC NANOPARTICLES IN AN IONIC LIQUID AND ASSOCIATED METHOD - The invention relates to a composition for synthesizing bimetallic nanoparticles, wherein the composition contains a first organometallic precursor and a second organometallic precursor having different decomposition rates and contained within an ionic liquid solution. The invention also relates to a method for synthesizing bimetallic nanoparticles, in which the composition is transformed under a hydrogen gas pressure between 0.1 and 10 MPa at a temperature between 0 and 150° C. until a suspension of bimetallic nanoparticles is obtained. The resulting nanoparticles are useful in diverse fields including the fields of catalysis and microelectronics. | 11-22-2012 |
20120264104 | METHOD FOR THE HYPOTHERMIC PERFUSION OF A CARDIAC ORGAN, AND DEVICE FOR THE IMPLEMENTATION THEREOF - The present invention relates to a method and device for the hypothermic perfusion of a cardiac organ. According to the invention, the infusion device comprises: a. a first sealed tank ( | 10-18-2012 |
20120225141 | SUBSTANCE FOR RESTORING NORMAL CO-EXPRESSION AND INTERACTION BETWEEN THE LOX AND NRAGE PROTEINS - The disclosed substance restores normal co-expression and interaction between the LOX and NRAGE proteins. Particularly, an effective amount of the substance that modulates the expression and/or activity of LOX of SEQ ID NO: 1 and/or that modulates the expression and/or activity of NRAGE of SEQ ID NO: 2, may be used for the manufacture of a composition for modulating the interaction between the LOX and NRAGE proteins to regulate the balance between the cellular phenomena of proliferation, differentiation and apoptosis, particularly in cases where the balance between these phenomena is disturbed, and especially in cases where the interaction between LOX and NRAGE is absent or altered. The invention makes it possible especially to treat and/or prevent skin ageing, lichen planus, graft-versus-host reaction (GVH), eczema, psoriasis and a cancer, particularly an epithelial cancer and more particularly a cutaneous epithelial cancer of basocellular or spinocellular type. | 09-06-2012 |
20120184557 | PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF - A compound of formula (I), or a pharmaceutically acceptable salt thereof, where R | 07-19-2012 |
20120128681 | Anti-CK8 Antibodies To Be Used For Treating Colorectal Cancers And Identifying Metastatic And/Or Invasive Phenotypes - The invention relates to antibodies specific to human CK8 and to pharmaceutical compositions for preventing and treating colorectal cancers. The invention also relates to methods for identifying colorectal cancers with an invasive and/or metastatic phenotype including detecting the cleavage of the C-terminal portion of human CK8 on the surface of tumour cells. | 05-24-2012 |
20120123070 | Catalytic Systems Made of a Complex of Rare Earths For Stereospecific Polymerisation Of Conjugated Dienes - La present invention relates to a multi-component catalytic system that can be used for the cis-1,4 stereospecific polymerization of conjugated dienes. The system is based on: | 05-17-2012 |
20120076788 | C-CBL AND ANTAGONISTS THEREOF FOR THE TREATMENT AND DIAGNOSIS OF CANCER - The present invention relates to the treatment of cancer. More specifically, the present invention relates to the use of c-cbl as a marker for the diagnosis and/or prognosis of cancer, and to the use of a c-cbl antagonist for the treatment of a cancer associated with resistance to apoptosis. | 03-29-2012 |
20120034229 | MONOCLONAL ANTIBODIES DIRECTED AGAINST LG4-5 DOMAIN OF ALPHA3 CHAIN OF HUMAN LAMININ-5 - The present invention relates to a monoclonal antibody binding to the LG4/5 domain of chain alpha3 of human protein laminin-5, wherein said monoclonal antibody inhibits the binding of syndecan-1 to said laminin-5 alpha3 chain LG4/5 domain, in particular 1H12 monoclonal antibody produced by the hybridoma cell line named 1H12 deposited on Jan. 8, 2008 at the C. N. C. M. under number 1-3890, as well as chimerized, humanized derivatives and fragments thereof, and nucleic acid sequences encoding them, as well as vectors and host cells expressing them. The invention further relates to the medical application of such antibodies, in particular for treating cancer. | 02-09-2012 |
20110229485 | INHIBITION OF THE NT-3:TRKC BOUND AND ITS APPLICATION TO THE TREATMENT OF CANCER SUCH AS NEUROBLASTOMA - The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (NT-3 or NT3), to the extracellular domain, or TrkC receptor and/or to inhibit the dimerization of the intracellular domain of the TrkC receptor expressed in tumor cells, particularly in neuroblastoma. The disclosure also relates to a method for predicting the presence of metastatic cancer or a bad prognosis cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of neurotrophin 3. The disclosure further comprises kits and compounds as a medicament for the treatment of neuroblastoma or cancer overexpressing neurotrophin 3 by the tumor cells. | 09-22-2011 |
20100330675 | INSULATING POLYNUCLEOTIDES DERIVED FROM ELEMENT D4Z4 AND THEIR USES IN TRANSGENESIS - Polynucleotides with insulating properties allowing protection of the expression of a transgene from adjacent cis elements in higher eukaryotic cells. In particular, these polynucleotides can be used for transgenesis, gene therapy and the production of recombinant proteins. | 12-30-2010 |
20100268476 | PROCESS FOR IDENTIFYING SIMILAR 3D SUBSTRUCTURES ONTO 3D ATOMIC STRUCTURES AND ITS APPLICATIONS - Our disclosure pertains to the field of structural biology and relates to a process to compare various three-dimensional (3D) structures and to identify functional similarities among them. Our process of comparison of 3D atomic structures is based on the comparisons of defined chemical groups onto the 3D atomic structures and allows the detection of local similarities even when neither the fold nor sequence for example aminoacid sequences for polypeptides sequences or nucleotide sequences for nucleic acid sequences are conserved. This process requires the attribution of selected physico-chemical parameters to each atom of a 3D atomic structure, then the representation of each 3D atomic structure by a graph of chemical groups. | 10-21-2010 |
20100184790 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF - The invention relates to pyrrolo[2,3-b]pyridine compounds and azaindole compounds used for the synthesis thereof. The invention also relates to methods for the production thereof and the uses thereof. Said novel pyrrolo[2,3-b]pyridine compounds according to the invention have great antiproliferative, apoptotic, and neuroprotective activities. The invention particularly applies to the pharmaceutical field. | 07-22-2010 |
20100174113 | AROMATIC SULPHONYLIMIDES, PREPARATION THEREOF AND USE THEREOF AS ELECTROLYTE - The invention relates to a process for preparing aromatic sulphonylimides, to the sulphonylimides obtained, and to the use thereof as salt of an electrolyte. The sulphonylimides correspond to the formula [R—SO | 07-08-2010 |
20100163432 | MICROSENSOR FOR DETECTION OF D-AMINO-ACIDS - The instant invention is about a microelectrode, in particular for measuring the concentration of a D-amino acid, said microelectrode comprising means for oxidation of said D-amino acid into at least a compound B, means for optimising the detection of said compound B, and means for reducing interferences, in particular interferences due to the oxidation of other species than compound B; a device comprising such a microelectrode; a method for making such a microelectrode, a method for detecting and/or measuring the concentration of a D-amino-acid in a medium. | 07-01-2010 |
20100062540 | Method for Detecting Aggregate-Forming Circulating Protein Forms Using an Agent for Aggregating Said Forms and an Agent for Capturing Formed Aggregates - The present invention concerns a method for detecting aggregate-forming circulating protein forms in a biological sample of human origin that may contain said aggregate-forming circulating protein forms, characterized in that it uses a non-protein agent I producing aggregation of the circulating forms of the noninfectious proteins involved in pathological aggregation processes of the central nervous system and/or a non-protein agent II for capturing the natural aggregrates of aggregate-forming circulating protein forms or the aggregates induced by said agents I. | 03-11-2010 |
20100016580 | Process for the preparation of functionalised benzocyclobutenes, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid - Process for the preparation of compounds of formula (IV): | 01-21-2010 |
20090276179 | OPTIMIZATION AND CONTROL OF THE FREEZE-DRYING PROCESS OF PHARMACEUTICAL PRODUCTS - A system is described for monitoring the lyophilisation process of a product in containers ( | 11-05-2009 |
20090242753 | DEVICE AND MASS ANALYSIS OF MOLECULES USING UV OR VISIBLE LASER BEAM PHOTODISSOCIATION - The invention relates to a device for mass analysis of molecules comprising a quadripolar ion trap equipped with an inlet for injection of molecules to be analysed in ionised form and an outlet for ejection of the ions to be detected, comprising an electrode system for generating a three-dimensional quadripolar field, capable of trapping the molecules to be analysed in ionised form, as a function of their mass to charge (m/z) ratio in a trapping volume, said trap being coupled to a UV or visible laser beam ensuring dissociation of the molecules to be analysed, characterised in that the laser beam is introduced to the trap without passing via fibre optics via an opening made in one of the electrodes, separate from the inlet and the outlet and blocked tightly by a viewing window allowing the laser beam to pass through, the dimension of the viewing window being selected such that the laser beam covers the entire trapping volume, as well as a process for mass analysis, with laser beam dissociation. | 10-01-2009 |
20090051686 | SIMULATION OF DYNAMIC CITY ENVIRONMENTS AND A RELATED FABRICATION METHOD - A method of dynamic generation by computer simulation of spatial elements, in particular, buildings and roads, constituting a three-dimensional city environment, the method comprising providing a supervisor subroutine responsible for overall control of the simulation; providing a spatial reorganization subroutine subordinate to the supervisor subroutine and responsible for generating the city environment on a local scale; placing a spatial element in the simulation; generating an inquiry from the supervisory subroutine which is sent to the spatial reorganization subroutine and providing spatial materialization of the inquiry by the spatial reorganization subroutine, which involves agents wherein at least some of the agents are able to negotiate with one another. | 02-26-2009 |
20080244840 | PROCESS FOR MODIFYING ARAMID FIBERS AND PROCESS FOR DYEING SAID FIBERS - This invention relates to a process for modifying aramid fibers so as to improve their capacity to be dyed, including the following steps:
| 10-09-2008 |