| UNIVERSITÄT ZÜRICH Patent applications |
| Patent application number | Title | Published |
|---|
| 20120116060 | Blockers of NMDA Receptor for the Treatment of Sickle Cell Anemia - Sickle cell anemia is a genetic disease characterized by red blood cells that assume an abnormal, rigid, sickle shape. Acute complications of Sickle cell anemia are treated symptomatically with analgesics and transfusions, and a prophylactic treatment of sickle cell crisis is long term application of hydroxyurea. According to the present invention, an N-methyl D-aspartate receptor (NMDAR) blocker is used for the treatment of sickle cell anemia and for manufacture of a medicament for the treatment of sickle cell anemia. Moreover, a method for screening for a compound effective in the treatment of sickle cell anemia comprises contacting a candidate compound with the NMDAR and selecting said candidate compound as effective if it is found to selectively reduce activity of the NMDAR. | 05-10-2012 |
| 20110294702 | TEMPLATE FIXED BETA-HAIRPIN LOOP MIMETICS AND THEIR USE IN PHAGE DISPLAY - Template-fixed β-hairpin mimetics and libraries including a plurality of these mimetics are provided. The template-fixed β-hairpin mimetics are of the following general formula: | 12-01-2011 |
| 20110230426 | TEMPLATE-FIXED PEPTIDOMIMETICS - Template-fixed β-hairpin peptidomimetics of the general formula | 09-22-2011 |
| 20110195515 | Capillary Plate and Method for Growth and Analysis of Macromolecular Crystals - A capillary plate and method for growing macromolecular crystals using the capillary plate. The capillary plate allows proteins and other macromolecules to be crystallized in the counter-diffusion method in a restricted geometry. Using this procedure, crystals can be adequately prepared for direct X-ray data analysis such that the macromolecule's three-dimensional structure can be solved without crystal manipulation. | 08-11-2011 |
| 20110135576 | DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS - Dye conjugates of template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 14 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties, and are useful for cancer therapy; diagnostic imaging; for detection of tumors and other abnormalities; for photoacoustic tumor imaging, detection and therapy; and for sonofluorescence tumor imaging, detection and therapy. The various dyes forming part of these conjugates are useful over the range of 300-1200 nm, the exact range being dependent upon the particular dye. These dye conjugates of β-hairpin peptidomimetic can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy. | 06-09-2011 |
| 20110123637 | PROTAMINE/RNA NANOPARTICLES FOR IMMUNOSTIMULATION - The present invention relates to protamine/RNA nanoparticles of defined average size, a pharmaceutical composition containing said nanoparticles and to a method of producing the same. The nanoparticles of the present invention is particularly useful as an immunostimulating medicament with a precise pattern of immunostimulation different from the prior art. | 05-26-2011 |
| 20110115486 | TRAVELLING-WAVE NUCLEAR MAGNETIC RESONANCE METHOD - A method for acquiring an image or spectrum of a subject or object residing within the magnetic field of a magnetic resonance apparatus, comprises the steps of:
| 05-19-2011 |
| 20110094566 | Luminescence Concentrators and Luminescence Dispersers on the Basis of Oriented Dye Zeolite Antennas - A luminescence concentrator (LK) may concentrate both incident direct and diffuse light by way of frequency shift and total internal reflection. It differs fundamentally from geometric concentrators. With sufficient geometric expansion of the collector plate, nearly arbitrarily high concentration can be achieved in the LK. A luminescence disperser is an apparatus which holds both directional and nondirectional incident light captive in a transparent body by way of frequency shift and total internal reflection and emits it diffusely or directionally uniformly distributed across an area by way of luminescence emission. The object of the invention is a method for the technical implementation of the LK and luminescence disperser, using zeolite crystals having a nanotube structure, into which the luminescent dyes are embedded such that they have antenna properties. Using the resulting novel structures, problems can be solved which made the technical use of LK impossible or at least considerably limited it. This results in completely novel usage possibilities for collecting and concentrating sun light and feeding it into photovoltaic systems, for converting it into electric and thermal energy in combined photovoltaic/hot water apparatuses, and for feeding it into fiber optic apparatuses. | 04-28-2011 |
| 20110060401 | Tubular Supporting Prosthesis Capable of Growing - The invention relates to a tubular supporting prosthesis capable of growing, comprising a mesh structure, wherein the mesh structure comprises at least two structural rings, which are connected to each other via connecting members and are disposed point-symmetrically about the longitudinal supporting prosthesis axis, wherein the structural rings and/or the connecting members have at least one predetermined breaking point. | 03-10-2011 |
| 20100240083 | METHOD FOR THE DETECTION OF THE IN-VIVO ACTIVITY OF NEUROTRYPSIN, USE OF THE METHOD AND USE OF THE C-TERMINAL, 22-KDA FRAGMENT OF AGRIN AS BIOMARKER IN DIAGNOSIS AND MONITORING OF NEUROTRYPSIN-RELATED DISTURBANCES - Method for the detection of the in-vivo activity of neurotrypsin wherein the amount of the 22-kDa-fragment of agrin is measured in a sample taken from a patient and the measured amount of the 22-kDa-fragment of agrin in the sample is used to calculate the activity of neurotrypsin, use of the method for diagnosis and monitoring of neurotrypsin-related disturbances and use of the 22-kDa-fragment of agrin as biomarker for neurotrypsin-related disturbances. | 09-23-2010 |
| 20100196440 | Implant Material - The present relates to the field of dental and bone surgery. In particular, the invention relates to fibrous pharmaceutical compositions; fibrous webs, yarns and woven fabrics of such pharmaceutical compositions; to implant material essentially consisting of fibrous pharmaceutical compositions; to the manufacturing and use of such fibers/webs/implant materials. | 08-05-2010 |
| 20100121423 | Stent with Vessel Valve - The invention relates to a stent that comprises a single sinus section and is preferably provided at the proximal end thereof with a native vessel valve ( | 05-13-2010 |
| 20100056432 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIBACTERIAL ACTIVITY - Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of | 03-04-2010 |
| 20100041132 | Bioreactor System - In one aspect the invention provides a bioreactor system for the production of tissue prostheses. The system includes a bioreactor, a culture medium reservoir coupled to the bioreactor by a first conduit and a second conduit, a pump operable to pump fluid into and draw fluid out of a pumping chamber defined in the bioreactor to generate a pulsatile flow of culture medium through the reservoir and bioreactor via said first and second conduits, one or more flow meters operable to generate flow rate signals representative of the rate of culture medium flow through one or both of said first and second conduits, and a controller arranged to receive said flow rate signals from said one or more flow meters and to control the pump means in response to said received flow rate signals to provide a desired rate of culture medium flow. | 02-18-2010 |
| 20090295389 | MAGNETIC FIELD PROBE AND METHOD FOR MANUFACTURING THE SAME - A magnetic field probe comprises a sample ( | 12-03-2009 |
| 20090261828 | COIL ASSEMBLY AND MULTIPLE COIL ARRANGEMENT FOR MAGNETIC RESONANCE IMAGING - A coil assembly for magnetic resonance imaging comprises a sheet ( | 10-22-2009 |
| 20090169602 | Allergy Treatment by Epicutaneous Allergen Administration - The invention provides pharmaceutical compositions, kits, and methods for the treatment of allergy. The compositions are adapted for epicutaneous administration and comprise an allergen and at least one pharmaceutically acceptable excipient. They may be designed as adhesive patches, intradermal delivery devices, ointments, gels, sprays, or similar types of formulation suitable for administration to the skin. Furthermore, the invention provides the use of such compositions in the treatment of allergy. In particular, the compositions are administered to pre-treated skin, wherein the pre-treatment comprises partial or complete dekeratinisation of the epidermis at the selected site of administration. | 07-02-2009 |
| 20090149783 | System And Method For A Cooperative Arm Therapy And Corresponding Rotation Module - A system for arm therapy of a user comprises a device for determining the position of the user, a first drive, an upper arm rotation module, an upper arm cuff, at least one hinge movably connecting the upper arm cuff and the first drive, a second drive, and a rotation drive provided on the upper arm rotation module itself. The upper arm cuff is connected to the arm of the user and has a substantially hollow-cylindrical shape when it is closed. The first drive and the second drive are adapted to place the upper arm rotation module in a defined spatial position, and the rotation drive is adapted to turn the upper arm cuff about its main axis relative to the outer part of the upper arm rotation module. | 06-11-2009 |
| 20090131862 | METHOD AND DEVICE FOR ACCURATE DISPENSING OF RADIOACTIVITY - A device and a method for accurate and remote dispensing of a radioactive liquid are disclosed. A source of a radioactive liquid ( | 05-21-2009 |
| 20090118134 | Template Fixed Beta-Hairpin Loop Mimetics and Their Use in Phage Display - Template-fixed β-hairpin mime tics of the general formula R | 05-07-2009 |
| 20090082274 | Collections of repeat proteins comprising repeat modules - The present invention relates to collections of repeat proteins comprising repeat modules which are derived from one or more repeat units of a family of naturally occurring repeat proteins, to collections of nucleic acid molecules encoding said repeat proteins, to methods for the construction and application of such collections and to individual members of such collections. | 03-26-2009 |
| 20090068218 | Antigens for Vaccination Against and Detection of Mycoplasma Suis - The present invention relates to antigens for vaccination against and detection of | 03-12-2009 |
| 20090054345 | Template-Fixed Beta-Hairpin Peptidomimetics With Protease Inhibitory Activity - Templates-fixed β-hairpin peptidomimetics of the general formulae (I), wherein Z is a chain of 11α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy. | 02-26-2009 |
| 20080287813 | Blood Pressure Monitoring Device and Methods for Making and for Using Such a Device - Disclosed are a system and a method for noninvasively and continuously monitoring blood pressure. Also disclosed is a method for making such a device. The system includes a semiconductor chip comprising a transducer array of individual pressure or force sensors and associated circuitry providing control signals to and/or processing signals from these sensors, all of the above integrated in the chip. Also disclosed is a specific sensor structure provided on said chip. The invention further encompasses a system for measuring and/or tracking the blood pressure waveform and for combining the latter with related blood values like the heartbeat, derived from the above or other measuring devices. | 11-20-2008 |
